TSUZAKA Kensei 津阪憲政

… Alternative Names

津坂憲政ツザカケンセイ

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Researcher Number	00245490
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2013: Tokyo Dental College, 歯学部, 准教授 2000 – 2007: Saitama Medical School, Instructor, 医学部, 講師 1997 – 2000: 埼玉医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / 内科学一般 Except Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator alternative splicing / 全身性エリテマトーデス / signal transduction / mRNA 3'UTR / TCRζ鎖 / EXTL2 / syndecan / Systemic lupus erythematosus / mRNA3'UTR / MA5.8 … More / シンデカン / TCR ζ / exon deletion / syndecan-1 / cDNA microarray / ヘパラン硫酸 / signla transduction / Syndecan / TCRζ / 半定量PCR法 / dimerization / In vitro translation / RNA結合タンパク / 3' UTR / ノックアウトマウス / TCR / 3'UTR / knockout mouse / SLE / TCR zeta / クローニング / 自己抗体 / クローリング / 分子生物学 / 自己免疫疾患 / 抗核抗体 / 抗DNA抗体 / リボゾーム蛋白S1 … More Except Principal Investigator autoimmunity / SLE / CD103 / TCRζ chain / BAFF / 自己免疫 / インテグリン / apoptosis / adhesion / epithelial cells / Integrins / integrin / adherin / epithelial injuries / カドヘリン / 上皮障害 / microarray / splicing variants / autoantibody / 3'untranslated region / splicing / 3' untranslated region / T lymphocytes / tyrosine phosphorylation / CD3 zeta chain / lupus / T cell receptor / signaal transduction / チロシンリン酸化 / T細胞リセプター / シグナル伝達 / TCRζ鎖 / E-cadherin / シェ-グレン症候群 / シェーグレン症候群 / アポトーシス / 組織障害 / E-カドヘリン / E-cadherins / PTPN1 / JMJD1A / 機能解析 / 末梢血 / FAM20A / 14-3-3zeta / 発現異常 / mRNA / 病態形成 / 網羅的遺伝子解析 / 遺伝子発現 / DNAマイクロアレイ / 関節リウマチ Less

Identification and characterization of pathogenesis related molecules in early rheumatoid arthritis by DNA microarray
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Keio University
Mechanism of systemic lupus erythematosus accompanied with the aberrant TCR zeta mRNA 3'UTRPrincipal Investigator
- Principal Investigator
  
  TSUZAKA Kensei
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Dental College
Molecular mechanism and its regulation of heterophilic adhesion between α E 3 7 (CD103) and E-cadherin in autoimmune epithelial injury
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saitama Medical University
Decreased expression of TCRζ and signal transduction due to the aberrantexpression of the TCR mRNA in SLE patient T cellsPrincipal Investigator
- Principal Investigator
  
  TSUZAKA Kensei
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saitama Medical University
Molecular mechanism and possible therapeutic target of BAFF upregulation in SLE
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical School
Analysis of the aberrant TCRζ mRNA 3'UTR in SLE patient T cellsPrincipal Investigator
- Principal Investigator
  
  TSUZAKA Kensei
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical School
全身性エリテマトーデス患者T細胞に発現されるTCRζ鎖の異常に関する研究
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical School
リボゾーム蛋白S1による抗DNA抗体産生の機序に関する研究Principal Investigator
- Principal Investigator
  
  津坂憲政 (津坂憲政)
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical University
Role of alphaEbeta7 on tissue destruction of autoimmune diseases
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical School

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] SLEではT細胞にシグナル異常があるか。皮膚科膠原病診療のすべて。古江増隆・佐藤伸一編集2011
- Author(s)
  津坂憲政
- Publisher
  中山書店(東京)
- Data Source
  KAKENHI-PROJECT-21591268
[Book] リウマチ、膠原病最新トピックス2005
- Author(s)
  津坂憲政
- Publisher
  診断と治療社(東京)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] シェーグレン症候群2013
- Author(s)
  津坂憲政, 浮地賢一郎
- Journal Title
  
  ザ・クインテッセンス
  
  Volume: 32 Pages: 142-146
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] RAにおけるADAMTS-10の異常発現と血管新生2013
- Author(s)
  津坂憲政
- Journal Title
  
  リウマチ科
  
  Volume: 50 Pages: 112-114
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] CD3ζdefects in systemic lupus erythematosus2012
- Author(s)
  Takeuchi T, Suzuki K, Kondo T, Yoshimoto K, Tsuzaka K
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71(Suppl), 2
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome2011
- Author(s)
  Yoshimoto K, Tanaka M, Kojima M, Setoyama Y, Kameda H, Suzuki K, Tsuzaka K, Ogawa Y, Tsubota K, Abe T, Takeuchi T
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13(5)(Epub)
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] Decreased mRNA expression of two FOXP3 isoforms in peripheral blood mononuclear cells from patients with rheumatoid arthritis and systemic lupus erythematosus2011
- Author(s)
  Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
- Journal Title
  
  Int J Immunopathol Pharmacol
  
  Volume: 24 Pages: 7-14
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] Decreased mRNA expression of two Foxp3 isoforms in peripheral blood mononuclear cells from patients with rheumatoid arthritis and systemic lupus erythematosus2011
- Author(s)
  Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
- Journal Title
  
  Int J Immunopathol and Pharmacology
  
  Volume: 24 Pages: 7-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390259
[Journal Article] Single center prospective study of tacrolimus efficacy and safety in treatment of rheumatoid arthritis2011
- Author(s)
  Suzuki K, Kameda H, Amano K, Nagasawa H, Takei H, Sekiguchi N, Nishi E, Ogawa H, Tsuzaka K, Takeuchi T
- Journal Title
  
  Rheumatol Int
  
  Volume: 31 Pages: 757-763
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] Reduced Expression of TCR zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus2010
- Author(s)
  Yoshimoto K, Setoyama Y, Tsuzaka K, Abe T, Takeuchi T
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: (Epub)
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] ADAMTS5 is a biomarker for prediction of the response to Infliximab in patients with rheumatoid arthritis2010
- Author(s)
  Tsuzaka K, Itami Y, Takeuchi T, Shinozaki N, Morishita T
- Journal Title
  
  J Rheumatol
  
  Volume: 37 Pages: 1454-1460
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] ADAMTS5 is a biomarker for prediction of the response to Infliximab in patients with rheumatoid arthritis.2010
- Author(s)
  Tsuzaka K, Itami Y, Takeuchi T, et al.
- Journal Title
  
  J Rheumatol
  
  Volume: 37 Pages: 1454-1460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] Reduced Expression of TCR zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus2010
- Author(s)
  Yoshimoto K, Setoyama Y, Tsuzaka K, et al.
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: (Epub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] IgG4関連自己免疫性疾患(形質細胞浸潤)2009
- Author(s)
  津坂憲政
- Journal Title
  
  別刷日本臨床呼吸器症候群
  
  Pages: 135-137
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] 関節リウマチ2009
- Author(s)
  津坂憲政
- Journal Title
  
  小児科 50
  
  Pages: 1999-2004
- Data Source
  KAKENHI-PROJECT-21591268
[Journal Article] The conservative sequences in 3'UTR of TCRζ mRNA regulate the production of TCRζ and TCR/CD3 complex in SLE T cells2008
- Author(s)
  Tsuzaka Kensei, et. al.
- Journal Title
  
  BBRC 367
  
  Pages: 311-317
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] T The conservative sequences in 3' UTR of TCRtξ mRNA regulate the production of TCRξ and TCR/CD3 complex in SLE T cells.2008
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Suzuki, M, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Journal Title
  
  BBRC 367
  
  Pages: 311-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] The conservative sequences in 3'UTR of TCRζ mRNA regulate the production of TCRζ and TCR/CD3 complex in SLE T cells.2008
- Author(s)
  Tsuzaka Kensei, et. al.
- Journal Title
  
  BBRC 367
  
  Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Down-regulation of Fas-ligand mRNA Shogren' syndrome patients with enlarged exocrine glands2007
- Author(s)
  Tsuzaka Kensei, et. al.
- Journal Title
  
  Autoimmunity 40
  
  Pages: 497-502
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Down-regulation of Fas-ligand mRNA in Sjogren's syndrome patients with enlarged exocrine glands2007
- Author(s)
  Tsuzaka, K, Matsumoto, Y, Sasaki, Y, et. al.
- Journal Title
  
  Autoimmunity 40
  
  Pages: 497-502
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Prospective study of low dose cyclosporine A in patients with refractory lupus nephritis2007
- Author(s)
  Ogawa, H, Kameda, H, Nagasawa, H, Sekiguchi, N, Takei, H, Tsuzaka, K, Amano, K, d Takeuchi, T
- Journal Title
  
  Mod Rheum 17
  
  Pages: 92-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Down-regulation of Fas-ligand mRNA Shogren' syndrome patients with enlarged exocrine glands2007
- Author(s)
  Tsuzaka, K, Matsumoto, Y, Sasaki, Y, Abe, T, Tsubota, K, Takeuchi, T
- Journal Title
  
  Autoimmunity 40
  
  Pages: 497-502
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Down-regulation of Fas-ligand mRNA in Sjogren's syndrome patients with enlarged exocrine glands2007
- Author(s)
  Tsuzaka K, Matsumoto Y, Sasaki Y, et. al.
- Journal Title
  
  Autoimmunity 40
  
  Pages: 497-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Down-regulation of Fas-ligand mRNA Shogren' syndrome patients with enlarged exocrine glands2007
- Author(s)
  Tsuzaka Kensei, et. al.
- Journal Title
  
  Autommunity 40
  
  Pages: 497-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Efficacy and Safety of Tacrolimus in Patients with rheumatoid arthritis in clinical practice : Significant role of blood concentration measurement for preventing severe adverse events2007
- Author(s)
  Suzuki, K, Takei, H, Kameda, H, Nagasawa, H, Sekiguchi, N, Nishi, E, Ogawa, H, Tsuzaka, K, Amano, K, Takeuchi, T
- Journal Title
  
  Arthritis Rheum S 35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] DNA microarray gene expression profile of T cells with splice variants of TCRz mRNA observed in SLE2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, Shiraishi, K, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Journal Title
  
  J Immunol 176
  
  Pages: 949-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] TCRz mRNA splice variant forms observed in peripheral blood T cells from systemic lupus erythematosus patients2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, Shiraishi, K, Setoyama, Y, Yoshimoto, K, Abe, T, Takeuchi, T
- Journal Title
  
  Springer Seminars in Immunopathology 28
  
  Pages: 185-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] DNA microarray gene expression profile of T cells with the splice variants of TCRζ mRNA observed in SLE2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, et. al.
- Journal Title
  
  J Immunol 176
  
  Pages: 949-956
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] DNA microarray gene expression profile of T cells with the splice variants of TCRζ mRNA observed in SLE2006
- Author(s)
  Tsuzaka K, Nozaki K, Kumazawa C, et. al.
- Journal Title
  
  J Immunol 176
  
  Pages: 949-956
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] TCRゼータ鎖ヴァリアントに起因する二次的分子異常の検索2006
- Author(s)
  津坂憲政
- Journal Title
  
  リウマチ科 35
  
  Pages: 6-10
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Molecular abnormalities of T cells in systemic lupus erythematosus2006
- Author(s)
  Takeuchi, T, Tsuzaka, T, Kameda, H, Amano, K
- Journal Title
  
  APLAR journal of Rheum 9
  
  Pages: 365-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] TCRζ mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients2006
- Author(s)
  Tsuzaka K, Nozaki K, Kumazawa C, et. al.
- Journal Title
  
  Springer Semin lmmunopathol 28
  
  Pages: 185-193
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] DNA microarray gene expression profile of T cells with splice variants of TCRz mRNA observed in SLE2006
- Author(s)
  Tsuzaka Kensei
- Journal Title
  
  J Immunol 176
  
  Pages: 949-956
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] DNA microarray gene expression profile of T cells with cplice variants of TCRζ mRNA observed in SLE.2006
- Author(s)
  Tsuzaka Kensei
- Journal Title
  
  J Immunology 176
  
  Pages: 949-956
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy2006
- Author(s)
  Yoshimoto, K, Takahashi, Y, Ogasawara, M, Setoyama, Y, Suzuki, K, Tsuzaka, K, Abe, T, Takeuchi, T
- Journal Title
  
  Int Immunol 18
  
  Pages: 1189-96
- NAID
  10020618413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] TCRζ mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients2006
- Author(s)
  Tsuzaka Kensei
- Journal Title
  
  Springer Semin Immunopathol 28
  
  Pages: 185-193
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] DNA microarray gene expression profile of T cells with the splice variants of TCRζ mRNA observed in SLE2006
- Author(s)
  Tsuzaka Kensei
- Journal Title
  
  Journal of Immunology 176
  
  Pages: 949-956
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] TCRζ mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, et. al.
- Journal Title
  
  Springer Semin Immunopathol 28
  
  Pages: 185-193
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] A splice variant of the TCR ζ mRNA lacking exon 7 leads to the down-regulation of TCR ζ, the TCR/CD3 complex, and IL-2 production in SLE T cells2005
- Author(s)
  Tsuzaka K, Setoyama Y, Yoshimoto K, et.
- Journal Title
  
  J Immunol 174
  
  Pages: 3518-3525
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] T cell abnormalities in systemic lupus erythematosus2005
- Author(s)
  Takeuchi, T, Tsuzaka, K, Abe, T, et. al.
- Journal Title
  
  Autoimmunity 38
  
  Pages: 339-346
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Critical role of the fifth domain of E-cadherin for heterophilic adhesion with αEβ7, but not for homophilic adhesion.2005
- Author(s)
  Shiraishi K, Tsuzaka K, Kumazawa C, et al.
- Journal Title
  
  J Immunol 175
  
  Pages: 1014-1021
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] TCRζ鎖障害によって惹起される二次的分子異常2005
- Author(s)
  津坂憲政
- Journal Title
  
  炎症と免疫 13
  
  Pages: 633-639
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] A splice variant of the TCRζmRNA lacking exon 7 leads to the down-regulation of TCR ζ the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells.2005
- Author(s)
  Tsuzaka K, Setoyama Y, Yoshimoto K, Shiraishi K, et al.
- Journal Title
  
  Journal of Immunology 174
  
  Pages: 3518-3525
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Therapeutic targets in misguided T cells in systemic lupus erythematosus.2005
- Author(s)
  Takeuchi T, Tsuzaka K, Kameda H, et al.
- Journal Title
  
  Current Drug Target 4
  
  Pages: 295-298
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Therapeutic targets in misguided T cells in systemic lupus erythematosus2005
- Author(s)
  Takeuchi, T, Tsuzaka, K, Kameda, H, et. al.
- Journal Title
  
  Current Drug Target 4
  
  Pages: 295-298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Critical role of the fifth domain of E-cadherin for heterophilic adhesion with a E β 7, but not for homophilic adhesion2005
- Author(s)
  Shiraishi, K, Tsuzaka, K, Kumazawa, C, et. al.
- Journal Title
  
  J Immunol 175
  
  Pages: 1014-1021
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] A splice variant of the TCR mRNA lacking exon 7 leads to the down-regulation of TCRζ, the TCR/CD3 complex, and IL-2 production in SLE T cells.2005
- Author(s)
  Tsuzaka, K, Setoyama, Y, Yoshimoto, K, et. al.
- Journal Title
  
  J Immunol 174
  
  Pages: 3518-3525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] T cell abnormalities in systemic lupus erythematosus.2005
- Author(s)
  Takeuchi T, Tsuzaka K, Abe T, et al.
- Journal Title
  
  Autoimmunity 38
  
  Pages: 339-346
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] Altered expression of the T cell receptor-CD3 complex in systemic lupus erythematosus.2004
- Author(s)
  Takeuchi T, Tsuzaka K, Abe T
- Journal Title
  
  Int Rev Immunol 23
  
  Pages: 273-291
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] SLE発症前の自己抗体2004
- Author(s)
  津坂憲政, 竹内勤
- Journal Title
  
  内科 93
  
  Pages: 972-973
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] SLE患者に認められるTCRζ鎖スプライス・ヴァリアントの役割2004
- Author(s)
  津坂憲政
- Journal Title
  
  分子リウマチ 3
  
  Pages: 183-191
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] SLE T細胞の早期シグナル伝達異常2004
- Author(s)
  津坂憲政
- Journal Title
  
  臨床免疫 42
  
  Pages: 427-434
- Data Source
  KAKENHI-PROJECT-16590993
[Journal Article] 全身性エリテマトーデス患者T細胞におけるTCRζ鎖mRNAスプライス異常2004
- Author(s)
  津坂憲政
- Journal Title
  
  最新医学 59
  
  Pages: 2165-2178
- Data Source
  KAKENHI-PROJECT-16590993
[Presentation] Plasma short-talin is a new rheumatoid arthritis monitoring biomarker independent of the inflammatory markers.2013
- Author(s)
  Tsuzaka K, Takao M, Nishida J
- Organizer
  2013 ACR Annual Scientific Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] ADAMTS5 is a biomarker for the efficacy prediction of tocilizumab in rheumatoid arthritis2013
- Author(s)
  Tsuzaka K, Takao M, Nishida J
- Organizer
  2013 ACR Annual Scientific Meeting
- Place of Presentation
  SanDiego
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] ADAMTS5 is a biomarker for the efficacy prediction of tocilizumab in rheumatoid arthritis.2013
- Author(s)
  Tsuzaka K, Takao M, Nishida J
- Organizer
  2013 ACR Annual Scientific Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Plasma short-talin is a new rheumatoid arthritis monitoring biomarker independent of the inflammatory markers2013
- Author(s)
  Tsuzaka K, Takao M, Nishida J
- Organizer
  2013 ACR Annual Scientific Meeting
- Place of Presentation
  SanDiego
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] ニューモシスティス肺炎合併膠原病患者の気道検体Pneumocystis jiroveci DNA濃度、血清βD-glucan値の臨床的検討-気道検体conventional PCR陰性例を含む-2013
- Author(s)
  阿部治男、津坂憲政
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] 関節リウマチ患者に対するトシリズマブ休薬基準の検討（多施設共同研究）2013
- Author(s)
  金子礼志、津坂憲政、海辺剛志
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] 関節リウマチの新規診断マーカーおよびモニタリングマーカーとしての血中タリン2012
- Author(s)
  津坂憲政
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Talin is cleaved and expressed as a short form predominantly in patients with rheumatoid arthritis2012
- Author(s)
  Tsuzaka K, Takao Masako, Shinozaki N, Nishida J
- Organizer
  2012 ACR Annual Scientific Meeting
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Talin is cleaved and expressed as a short form predominantly in patients with rheumatoid arthritis.2012
- Author(s)
  Tsuzaka K
- Organizer
  2012 ACR Annual Scientific Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Plasma talin is a new diagnostic and monitoring marker for rheumatoid arthritis2011
- Author(s)
  Tsuzaka K, Itami Y, Shinozaki N, Morishita T
- Organizer
  2011 ACR Annual Scientific Meeting
- Place of Presentation
  米国、シカゴ
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Plasma talin is a new diagnostic and monitoring marker for rheumatoid arthritis2011
- Author(s)
  Tsuzaka K, Itami Y, Shinozaki N, Morishita T
- Organizer
  2011 ACR Annual Scientific Meeting
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Baseline ADAMTS5 expression could sort the prediction of response to infliximab or adalimumab in patients with rheumatoid arthritis2010
- Author(s)
  Tsuzaka K, Itami Y, Shinozaki N, Morishita T
- Organizer
  2010 ACR Annual Scientific Meeting
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] Baseline ADAMTS5 expression could sort the prediction of response to infliximab or adalimumab in patients with rheumatoid arthritis2010
- Author(s)
  Tsuzaka, K, et al.
- Organizer
  ACR Annual Scientific Meeting
- Place of Presentation
  米国、アトランタ
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] ADAMTS5 is a biomarker for prediction of the response to infliximab in patients with rheumatoid arthritis2009
- Author(s)
  Tsuzaka K, et al.
- Organizer
  ACR 72nd Annual Meeting
- Place of Presentation
  米国、フィラデルフィア
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-21591268
[Presentation] 14-kd protein binds to the conservative region in TCR zeta mRNA 3' UTR and regulates the production of TCR zeta and TCR/CD3 complex2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Organizer
  American College of Rheumatology 71st Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] A negative role of a unique integrin alphaEbeta7 on proliferative capability of human T cell line2007
- Author(s)
  Kumazawa, C, Shiraishi, K, Tsuzaka, K, Takeuchi, T
- Organizer
  The EULAR annual congress of rheumatology
- Place of Presentation
  Barcelona, Spain
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible involvement of MMP in the production of soluble BAFF in human T cells2007
- Author(s)
  Yoshimoto, K, Takahashi, Y, Setoyama, Y, Suzuki, K, Tsuzaka, K, Abe, T, Takeuchi, T
- Organizer
  The EULAR annual congress of rheumatology, Barcelona
- Place of Presentation
  Spain
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Decreased expression of the glycosylated syndecan 4 accompanied with down-regulation of TCR zeta in SLE patient T cells2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, et. al.
- Organizer
  ACR71st Annual Meeting Boston
- Place of Presentation
  U. S. A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Presentation] Decreased expression of the glycosylated syndecan 4 accompanied with down-regulationof TCR zeta in SLE patient T cells2007
- Author(s)
  Tsuzaka Kensei
- Organizer
  American College of Rheumatology, 71st Annual Meeting
- Place of Presentation
  Boston,U.S.A
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Decreased expression of theglycosylated syndecan 4 accompanied with down-regulation of TCR zeta in SLE patient T cells2007
- Author(s)
  Tsuzaka K, Itami Y, Kumazawa C
- Organizer
  ACR 71st Annual Meeting
- Place of Presentation
  Boston
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Presentation] Efficacy and safety of tacrolimus in patients with rheumatic disease : Appropriate clinical application for various rheumatic conditions2007
- Author(s)
  Suzuki, K, Kameda, H, Amano, K, Nagasawa, H, Sekiguchi, N, Takei, H, Nishi, E, Okuyama, A, Ogawa, H, Tsuzaka, K, Takeuchi, T
- Organizer
  American College of Rheumatology 71st Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] 14-kd protein binds to the conservative region in TCR zeta mRNA 3'UTR and regulates the production of TCR zeta and TCR/CD3 complex.2007
- Author(s)
  Tsuzaka Kensei
- Organizer
  American College of Rheumatology, 71st Annual Meeting
- Place of Presentation
  Boston,U.S.A.
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Decreased expression of the glycosylated syndecan 4 accompanied with down-regulation of TCR zeta in SLE patient T cells2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Organizer
  American College of Rheumatology 71st Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] TCR ξ and TCR/CD3 expression from the TCR C mRNA with deleted form of the conservative sequences in 3' UTR is down-regulated due to its instability2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Organizer
  37th Japanese society for Immunology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] SLE患者T細胞におけるシンデカン分子糖鎖発現異常2007
- Author(s)
  津坂憲政
- Organizer
  第51回日本リウマチ学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible involvement of MMP-9 in the production of BAFF in T cells2007
- Author(s)
  Yoshimoto, K, Setoyama, Y, Tsuzaka, K, Ogawa, Y, Tsubota, K, Abe, T, Takeuchi, T
- Organizer
  American uollege of Nheumatology Ylst Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] TCRζ and TCR/CD3 expression from the TCRζ mRNA with deleted form of the conservative se uences in 3'U丁R is down-reulated due to its instability.2007
- Author(s)
  Tsuzaka Kensei
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Decreased expression of the glycosylated syndecan 4 accompanied with down-regulation of TCR zeta in SLE patient T cells.2007
- Author(s)
  Tsuzaka K, Itami Y, Kumazawa C, et. al.
- Organizer
  American College of Rheumatology, 71st Annual Scientific Meeting
- Place of Presentation
  アメリカ、ボストン
- Data Source
  KAKENHI-PROJECT-16590993
[Presentation] Efficacy and Safety of Tacrolimus in Patients With Rheumatoid Arthritis in Clinical Practice : Significant Role of Blood Concentration Measurement for Preventing Severe Adverse Events2006
- Author(s)
  Suzuki, K, Takei, H, Kameda, H, Nagasawa, H, Sekiguchi, N, Nishi, E, Ogawa, H, Tsuzaka, K, Amano, K, Takeuchi, T
- Organizer
  70th Annual Meeting, Washington
- Place of Presentation
  D. C., U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Responsible region in 3'UTR of TCRz mRNA for producing TCR/CD3 including TCRz in SLE T cells2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, Setoyama, Y, Shiraishi, K, Abe, T, Takeuchi, T
- Organizer
  16th European Congress of Immunology
- Place of Presentation
  Paris, France
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Responsible region in 3'UTR of TCRz mRNA for producing TCR/CD3 including TCRz in SLE T cells2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, et. al.
- Organizer
  16th European Congress of Immunology Paris
- Place of Presentation
  France
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Presentation] Aberrant expression of BAFF in SLE T cells2006
- Author(s)
  Yoshimoto, K, Takahashi, Y, Setoyama, Y, Suzuki. K, Tsuzaka. K, Abe. T, Takeuchi, T
- Organizer
  The EULAR annual congress of rheumatology
- Place of Presentation
  Amsterdam, Holland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Decreased expression of glycosylated syndecan families due to reduced production of EXTL2 in SLE patient T cells2006
- Author(s)
  Tsuzaka Kensei
- Organizer
  第36回日本免疫学会総会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] DNA microarray gene expression profile of T cells with the splice variants of TCR mRNA observed in SLE2004
- Author(s)
  Tsuzaka, K, Setoyama, Y, Yoshimoto, K, et. al.
- Organizer
  ACR 68th Annual Meeting San Antonio
- Place of Presentation
  U. S. A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993
[Presentation] The conservative region in 3'UTR of TCRz mRNA regulates the production of TCRζ in SLE T cells
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, et. al.
- Organizer
  ACR 69th Annual Meeting San Diego
- Place of Presentation
  U. S. A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590993

1. TAKEUCHI Tsutomu (50179610)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. AMANO Koichi (00175928)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NAGASAWA Hayato (20306343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KATSUYA Suzuki (70306695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YOSHIMOTO Keiko (20383292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. 白石清之 (10383291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUZAKA Kensei 津阪 憲政

津坂憲 政 ツザカケン セイ

Research Projects

Research Products

Co-Researchers

Identification and characterization of pathogenesis related molecules in early rheumatoid arthritis by DNA microarray

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Mechanism of systemic lupus erythematosus accompanied with the aberrant TCR zeta mRNA 3'UTRPrincipal Investigator

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Molecular mechanism and its regulation of heterophilic adhesion between α E 3 7 (CD103) and E-cadherin in autoimmune epithelial injury

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Decreased expression of TCRζ and signal transduction due to the aberrantexpression of the TCR mRNA in SLE patient T cellsPrincipal Investigator

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Molecular mechanism and possible therapeutic target of BAFF upregulation in SLE

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Analysis of the aberrant TCRζ mRNA 3'UTR in SLE patient T cellsPrincipal Investigator

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全身性エリテマトーデス患者T細胞に発現されるTCRζ鎖の異常に関する研究

Principal Investigator

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リボゾーム蛋白S1による抗DNA抗体産生の機序に関する研究Principal Investigator

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Research Institution

Role of alphaEbeta7 on tissue destruction of autoimmune diseases

Principal Investigator

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Research Institution

[Book] SLEではT細胞にシグナル異常があるか。皮膚科膠原病診療のすべて。古江増隆・佐藤伸一編集2011

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[Book] リウマチ、膠原病最新トピックス2005

Author(s)

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Description

Data Source

[Journal Article] シェーグレン症候群2013

Author(s)

Journal Title

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[Journal Article] RAにおけるADAMTS-10の異常発現と血管新生2013

Author(s)

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[Journal Article] CD3ζdefects in systemic lupus erythematosus2012

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TSUZAKA Kensei 津阪憲政

津坂憲政ツザカケンセイ