Takeuchi Osamu 竹内修

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TAKEUCHI Osamu 竹内修

竹内修タケウチオサム

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Researcher Number	00249997
Other IDs
Affiliation (Current)	2025: 北里大学, 北里研究所病院, 部長補佐(研究)
Affiliation (based on the past Project Information) *help	2024: 北里大学, 北里研究所病院, 部長補佐(研究) 2017 – 2019: 北里大学, 北里研究所病院, 部長補佐(研究) 2014: (社)北里研究所, 北里研究所病院, 研究員 2009: (社)北里研究所, 北里研究所病院, 研究員 2003: 社団法人北里研究所, 北里研究所病院, 研究員 2002: 社団法人北里研究所, 北里研究所病院, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / 内科学一般 Except Principal Investigator Environmental pharmacy
Keywords	Principal Investigator IL-10 / 腸管マクロファージ / 腸管恒常性 / IBD / NLRP-3 / 炎症性腸疾患 / IL-1R / NLRP3 / protective immunity / Gamma interferon (IFN-γ) / TH1 / virulence plasmid / Yersinia enterocolitica … More Except Principal Investigator … More 脂質異常症 / 薬物輸送担体 / 薬物代謝酵素 / プロバイオティクス / 消化管 / コレステロール / 脂質異常症治療薬 / メタアナリシス / 薬物動態 / 小腸 Less

Elucidation of IL-1/IL-1 receptor pathway in gut macrophages involved in the maintenance of intestinal homeostasis by the mucosal immune systemPrincipal Investigator
- Principal Investigator
  
  竹内修
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kitasato University
Elucidation of gut microbiota-independent IL-10 production mechanism of intestinal macrophagesPrincipal Investigator
- Principal Investigator
  
  Takeuchi Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Evaluation of the clinical usefulness of probiotics for the prevention and treatment of lifestyle-related disease
- Principal Investigator
  
  SHIMIZU MIKIKO
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Keio University
Effects of probiotics on human intestinal absorption and metabolism of drugs.
- Principal Investigator
  
  SHIMIZU Mikiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Keio University
  Kyoritsu University of Pharmacy
エルシニア感染に対する病原性プラスミドの役割と宿主免疫応答についてPrincipal Investigator
- Principal Investigator
  
  竹内修
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  内科学一般
- Research Institution
  Kitasato Institute

All 2020 2019 2018 2017 2013 2009

All Journal Article Presentation

[Journal Article] Prexasertib increases the sensitivity of pancreatic cancer cells to gemcitabine and S-12019
- Author(s)
  Morimoto Yoshihito、Takada Kimihiko、Takeuchi Osamu、Takagi Akinori、Watanabe Kazuhiro、Hirohara Masayoshi、Hamamoto Tomoyuki、Masuda Yutaka
- Journal Title
  
  Oncology Reports
  
  Volume: 28 Pages: 669-689
- DOI
  10.3892/or.2019.7421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09393
[Journal Article] Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis2019
- Author(s)
  Okabayashi Shinji、Kobayashi Taku、Saito Eiko、Toyonaga Takahiko、Ozaki Ryo、Sagami Shintaro、Nakano Masaru、Tanaka Junichi、Yagisawa Keiji、Kuronuma Satoshi、Takeuchi Osamu、Hibi Toshifumi
- Journal Title
  
  Intestinal Research
  
  Volume: 17 Issue: 2 Pages: 218-226
- DOI
  10.5217/ir.2018.00117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09393, KAKENHI-PROJECT-19K08364
[Journal Article] A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis2018
- Author(s)
  Okabayashi Shinji、Kobayashi Taku、Nakano Masaru、Toyonaga Takahiko、Ozaki Ryo、Carla Tablante Maria、Kuronuma Satoshi、Takeuchi Osamu、Hibi Toshifumi
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 印刷中 Issue: 11 Pages: 2404-2412
- DOI
  10.1093/ibd/izy125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09393
[Journal Article] Mechanisms of metformin's anti-tumor activity against gemcitabine-resistant pancreatic adenocarcinoma2018
- Author(s)
  Suzuki Keiichi、Takeuchi Osamu、Suzuki Yukio、Kitagawa Yuko
- Journal Title
  
  International journal of oncology
  
  Volume: 54 Pages: 764-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09393
[Journal Article] Relationship between genetic polymorphism and mRNA expression of dihydrofolate reductase enzyme in a healthy Japanese population.2013
- Author(s)
  Hashiguchi M., Shimizu M., Takeuchi O., Hayashi T., Inoue S., Tanaka T., Tsuru T., Irie S., Kurokawa .T, Mochizuki M.
- Journal Title
  
  Jpn. J. Clin. Pharmacol. Ther.
  
  Volume: 44 Pages: 185-192
- NAID
  10031177985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] 高脂肪食がマウスの腸炎及び腸内細菌叢に与える影響に関する検討2020
- Author(s)
  宇田川文, 小林拓, 黒沼智, 竹内修, 日比則孝, 小林朋, 林芳, 和田安代, 日比紀文
- Organizer
  第23回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] NUDT15 variance increases DNA-incorporated thiopurine metabolites and lymphocyte apoptosis in patients with Inflammatory Bowel Disease2020
- Author(s)
  Hiroki Kiyohara, Takahiko Toyonaga, Satoshi Kuronuma, Aito Ueno, Shinji Okabayashi, Ryo Ozaki, Osamu Takeuchi, Sally A. Coulthard, Christopher P,F. Redfern, Hideki Terai, Yoichi Tanaka, Masaru Nakano, Toshifumi Hibi, Taku Kobayashi
- Organizer
  Congress of European Crohns and Colitis Organisation (ECCO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] 潰瘍性大腸炎患者のタクロリムスTDM用ソフトウェアの作成とその有用性2017
- Author(s)
  熊埜御堂沙英、田中潤、篠崎公一、小林拓、竹内修、黒沼智、佐上晋太郎、岡林慎二、渡辺由紀、石橋とよみ、中野雅、豊永貴彦、尾崎良、日比紀文、斎藤太寿、小林義和、齋藤雅俊
- Organizer
  第34回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] 腸管マクロファージにおけるIL-10産生機序の解明2017
- Author(s)
  竹内修、小林拓、豊永貴彦、黒沼智、Maria Carla、岡林慎二、佐上晋太郎、上野明紀、日比紀文
- Organizer
  第54回消化器免疫学会
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] Caco-2細胞におけるCYP1A/1B誘導機構2009
- Author(s)
  清水美貴子、田中佑京、竹内修、永田由樹、田村悦臣
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] プロバイオティクスの科学的エビデンスの構築-基礎と臨床研究の統合-(シンポジウム講演)2009
- Author(s)
  清水美貴子、杉田隆、竹内修、望月眞弓、田村悦臣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞におけるに乳酸菌のCYP1A/1B誘導機構2009
- Author(s)
  清水美貴子, 田中佑京, 竹内修, 永田由樹, 田村悦臣
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-19590123

1. SUGITA Takashi (10312076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. SHIMIZU Mikiko (90396391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. HASHIGUCHI Masayuki (10271355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 小林拓 (10424144)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results

Takeuchi Osamu 竹内 修

TAKEUCHI Osamu 竹内 修

竹内 修 タケウチ オサム

Research Projects

Research Products

Co-Researchers

Elucidation of IL-1/IL-1 receptor pathway in gut macrophages involved in the maintenance of intestinal homeostasis by the mucosal immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of gut microbiota-independent IL-10 production mechanism of intestinal macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of the clinical usefulness of probiotics for the prevention and treatment of lifestyle-related disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of probiotics on human intestinal absorption and metabolism of drugs.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エルシニア感染に対する病原性プラスミドの役割と宿主免疫応答についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prexasertib increases the sensitivity of pancreatic cancer cells to gemcitabine and S-12019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of metformin's anti-tumor activity against gemcitabine-resistant pancreatic adenocarcinoma2018

Author(s)

Journal Title

Data Source

[Journal Article] Relationship between genetic polymorphism and mRNA expression of dihydrofolate reductase enzyme in a healthy Japanese population.2013

Author(s)

Journal Title

NAID

Data Source

[Presentation] 高脂肪食がマウスの腸炎及び腸内細菌叢に与える影響に関する検討2020

Author(s)

Organizer

Data Source

[Presentation] NUDT15 variance increases DNA-incorporated thiopurine metabolites and lymphocyte apoptosis in patients with Inflammatory Bowel Disease2020

Author(s)

Organizer

Data Source

[Presentation] 潰瘍性大腸炎患者のタクロリムスTDM用ソフトウェアの作成とその有用性2017

Author(s)

Organizer

Data Source

[Presentation] 腸管マクロファージにおけるIL-10産生機序の解明2017

Author(s)

Organizer

Data Source

[Presentation] Caco-2細胞におけるCYP1A/1B誘導機構2009

Author(s)

Organizer

Place of Presentation

Takeuchi Osamu 竹内修

TAKEUCHI Osamu 竹内修

竹内修タケウチオサム