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Kohsaka Hitoshi  上阪 等

ORCIDConnect your ORCID iD *help
… Alternative Names

KOHSAKA Hitoshi  上阪 等

KOUSAKA Hitoshi  上坂 等

上坂 等  コウサカ ヒトシ

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Researcher Number 00251554
Other IDs
Affiliation (based on the past Project Information) *help 2016 – 2017: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2014 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授
2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授
2010: 東京医科歯科大学, 医学部, 准教授
2009: Tokyo Medical and Dental University, 医歯学総合研究科, 准教授 … More
2007 – 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 准教授
2006: Tokyo Medical and Dental University, Graduate School, Associate Professor, 大学院医歯学総合研究科, 准教授
2005 – 2006: Tokyo Medical and Dental University. Tokyo Medical and Dental University Graduate School, Department of Bioregulation, Associate Professor, 大学院医歯学総合研究科, 助教授
2001 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教授
2004: Tokyo Medical and Dental University, Graduate school, Associate professor, 大学院・ 医歯学総合研究科, 助教授
2002: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2000: 東京医科歯科大学, 大学院・医歯学総合研究科, 講師
1997 – 1999: 東京医科歯科大学, 医学部, 助手
1996: 東京医科歯科大学, 難治疾患研究, 助手
1994 – 1996: 東京医科歯科大学, 難治疾患研究所, 助手 Less
Review Section/Research Field
Principal Investigator
内科学一般 / 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology / General internal medicine (including Psychosomatic medicine) / Biological Sciences
Except Principal Investigator
内科学一般 / 膠原病・アレルギー・感染症内科学 / Immunology
Keywords
Principal Investigator
関節リウマチ / 多発性筋炎 / 慢性関節リウマチ / cell cycle / rheumatoid arthritis / 細胞周期 / 内科 / 治療 / 遺伝子治療 / p16 … More / サイクリン依存性キナーゼ / 皮膚筋炎 / ケモカイン / サイクリン依存性キナーゼ阻害因子 / 免疫学 / 膠原病学 / 膠原病 / 動物モデル / 主要組織適合性抗原 / マウス / シェア-ド・エピトープ / T細胞レパトワ / 遺伝子療法 / 自己免疫 / 内科学 / 自己免疫疾患 / 原発性免疫不全症 / II型サイトカイン / I型サイトカイン / リンパ球 / リウマチ性疾患 / 膠原病内科 / 細胞死 / インターロイキン23 / Cタンパク誘導性筋炎 / treatment / コラーゲン誘導性関節炎 / サイクリン依存性性キナーゼ / cyclin-dependent kinase inhibitor / ノックアウトマウス / 増殖抑制 / autoimmunity / CD8T cells / polymiositis / CD8T細胞 / animal models / enhropathy / 急性腎不全 / 腎障害 / gene therapy / Adenovirus / Gene Therapy / CDKI / Rheumatoid Arthritis / アデノウィルス / p21 / アデノウイルス / 膠原病内科学 / 自然免疫 / iPS / 筋炎 / 線維芽細胞 / 筋免疫 / マクロファージ / 細胞周期制御 / CDK4/6 / 治療法 / TREM-1 / CDK4/6阻害薬 / TREM-1リガンド / 病理学 / 薬学 / 臨床 / リウマチ学 / 細胞増殖抑制 / 自己抗体 / プロテインチップ / リコンビナント蛋白 / T細胞抗原受容体 / シェアード・エピトープ / 慢性間接リウマチ / サイトカイン / GM-CSF / 自己抗原 / 遺伝子免疫 / 免疫寛容 / 一卵性双生児 / レパートリー / イムノグロブリン / B細胞 … More
Except Principal Investigator
慢性関節リウマチ / 遺伝子療法 / 細胞周期 / サイトカイン / サイクリン依存性キナーゼインヒビター / 遺伝子治療 / サイクリン依存性キナーゼ / Lyn / c-Myc / p27 / gene therapy / B lymphocyte / CD40 / FDC / Bリンパ球 / 関節リウマチ / サイクリン依存性キナーゼ阻害因子 / 滑膜増殖 / animal model / adenovirus vector / cyclin-dependent kinase inhibitors / rheumatoid arthritis (RA) / 低分子化合物 / 増殖抑制 / 治療 / 内科 / 膠原病 / 動物モデル / アデノウイルスベクター / 関節リウマチ(RA) / CDKI / rheumatoid arthritis / サイクリン / cell cycle / antigen receptor / CDK inhibitor / cell death / Cdkインヒビター / p21 / 増殖 / 誘導的発現 / CDK / 抗原受容体 / CDKインヒビター / 細胞死 / autoimmune disease / cytokine / 自己免疫疾患 / cell contact / T lymphocyte / class switch / apoptosis / クラススッチ / CD40L / 濾泡性樹状細胞 / 細胞接触 / 細胞間接触 / Tリンパ球 / クラススイッチ / アポトーシス / Jagged1 / Th17アジュバントcurdlan / Th2アジュバント / アトピー性皮膚炎 / 腎炎 / NODマウス / Jaggedl / Notch ligands / curdlan / Th17アジュバント / アジュバント / アレルギー学 / 細胞増殖 / 炎症 / microRNA / シグナル伝達 / サイクリンキナーゼインヒビター Less
  • Research Projects

    (30 results)
  • Research Products

    (137 results)
  • Co-Researchers

    (25 People)
  •  Discovery of new pathological processes in autoimmune diseasesPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Tokyo Medical and Dental University
  •  New Theory-driven Treatment Development of Polymyositis and DermatomyositisPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Tokyo Medical and Dental University
  •  Studies of autoimmune myositis using iPS cellsPrincipal Investigator

    • Principal Investigator
      Kohsaka Hitoshi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Tokyo Medical and Dental University
  •  Fibroblast pathology for suppression of inflammatory diseasesPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Tokyo Medical and Dental University
  •  難治疾患病態理解のための筋免疫学創成への挑戦Principal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of new anti-rheumatic drugsPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  Qualitative analysis of adjuvant activities and its application to immunity-related diseases

    • Principal Investigator
      MATSUSHITA Sho
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Saitama Medical University
  •  Cyclin-dependent kinase 4/6 inhibition for treatment of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  関節リウマチの病態形成へのmicroRNAの関与と治療への応用

    • Principal Investigator
      野々村 美紀
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  プロテインチップとプロテオーム技術を用いた新自己抗体の網羅的探索Principal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  新たな自己免疫筋炎モデルによる多発筋炎・皮膚筋炎の新治療法の開発の試みPrincipal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  New treatment of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  Cell cycle regulation for treatment of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  遺伝子導入滑膜細胞のシグナル伝達機構の解析―DNAアレイ法との比較検討

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Cell cycle and diseasesPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Autoaggressive CD8 T cells in polymyositisPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical & Dental University
  •  Clinical Application of Cell Cycle Control Therapy to Rheumatoid Arthritis

    • Principal Investigator
      MIYASAKA Nobuyuki
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  慢性関節リウマチの細胞回転制御遺伝子誘導療法の実用化に向けた検討

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  サイクリン依存性キナーゼインヒビター遺伝子導入滑膜細胞のシグナル伝達機構の解析

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  New Therapy for Rheumatoid Arthritis with Cell Cycle RegulatorsPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical & Dental University
  •  自己免疫抑制ペプチドの系統的検索Principal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Cell Cycle Control for Treatment of Rheumatoid Arthritis

    • Principal Investigator
      MIYASAKA Nobuyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  慢性関節リウマチ関連HLAの新たな病因的役割の研究Principal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Study of CDK inhibitors in B cell immune response

    • Principal Investigator
      TSUBATA Takeshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      Medical Research Intitute, Tokyo Medical and Dental University
  •  自己免疫疾患となる末消T、B細胞レパトワの同定Principal Investigator

    • Principal Investigator
      上坂 等
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Gene Therapy of Rheumatoid ArthritisPrincipal Investigator

    • Principal Investigator
      KOHSAKA Hitoshi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  自己免疫疾患の寛容誘導療法、遺伝子免疫療法の開発Principal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  The development of the treatment of autoimmune diseases by cytokine gene transfer

    • Principal Investigator
      MIYASAKA Nobuyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      TOKYO MEDICAL & DENTAL UNIVERSITY
  •  慢性関節リウマチ一卵性双生児のB細胞レパートリーPrincipal Investigator

    • Principal Investigator
      上阪 等
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Control mechanisms for B cell apoptosis and differentiation

    • Principal Investigator
      TSUBATA Takeshi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
      Kyoto University

All 2017 2016 2015 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2001 Other

All Journal Article Presentation Book Patent

  • [Book] ステロイド薬の適応と副作用「よくわかる関節リウマチのすべて」(宮坂信之編集)2009

    • Author(s)
      上阪等
    • Publisher
      永井書店
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Book] ステロイドを使う主な病気「膠原病・リウマチ内科」(宮坂信之編著)2008

    • Author(s)
      上阪等
    • Publisher
      法研
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Book] 関節リウマチ病因新しい診断と治療のABC「関節リウマチ」(宮坂信之編集)2008

    • Author(s)
      上阪等
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Injury and subsequent regeneration of muscles activate local innate immunity to facilitate development and relapse of autoimmune myositis2015

    • Author(s)
      Kimura N, Hirata S, Miyasaka N, Kawahata K, Kohsaka H
    • Journal Title

      Arthritis Rheumatology

      Volume: 67 Issue: 6 Pages: 1107-1116

    • DOI

      10.1002/art.39592

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Journal Article] 関節リウマチはどのようにおこるのか2012

    • Author(s)
      上阪等
    • Journal Title

      からだの科学

      Volume: 273 Pages: 16-19

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] 滑膜線維芽細胞を標的とした治療法の開発2012

    • Author(s)
      上阪等
    • Journal Title

      最新医学

      Volume: 67(2) Pages: 281-286

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] 多発筋炎・皮膚筋炎マウスモデル2012

    • Author(s)
      上阪等
    • Journal Title

      Clinical Neuroscience

      Volume: 30(3) Pages: 309-312

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] 炎症性筋疾患の病態と治療「序」2011

    • Author(s)
      上阪等
    • Journal Title

      炎症と免疫

      Volume: 20(1) Pages: 32-33

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] 膠原病診療の現在と未来-ステロイド・ファーストからステロイド・フリーへ-2011

    • Author(s)
      上阪等、Peter Shane、亀田秀人、渥美達也
    • Volume
      107(4)
    • Pages
      687-699
    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] 三科の診る多発性筋炎・皮膚筋炎2011

    • Author(s)
      上阪等
    • Journal Title

      医学のあゆみ

      Volume: 239(1) Pages: 1-5

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice2011

    • Author(s)
      Nakashioya H, Nakano K, Watanabe N, Miyasaka N, Matsushita S, Kohsaka H
    • Journal Title

      Mod Rheumatol

      Volume: 23 Pages: 177-183

    • NAID

      10029362184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] 生物学的製剤T細胞活性化阻害薬2011

    • Author(s)
      上阪等
    • Journal Title

      日本内科学会雑誌

      Volume: 100(10) Pages: 2979-2984

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] ここまでわかった自己免疫疾患多発性筋炎/皮膚筋炎2011

    • Author(s)
      上阪等
    • Journal Title

      臨床検査

      Volume: 55(11) Pages: 1150-1155

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] Addition of the collagen binding domain of fibronectin potentiates the biochemical availability of hepatocyte growth factor for cutaneous wound healing2011

    • Author(s)
      Okiyama N, Kitajima T, Ito Y, Yokozeki H, Miyasaka N, Kohsaka H
    • Journal Title

      J Dermatol Sci

      Volume: 61 Pages: 215-217

    • NAID

      10030890602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] 多発性筋炎と皮膚筋炎2011

    • Author(s)
      上阪等
    • Journal Title

      ドクターサロン

      Volume: 55(4) Pages: 294-297

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints2011

    • Author(s)
      Toyomoto M, Ishido S, Miyasaka N, Sugimoto H, Kohsaka H
    • Journal Title

      Int Immunol

      Volume: 23 Pages: 215-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] 多発性筋炎モデル動物による病態解析2011

    • Author(s)
      木村直樹、上阪等
    • Journal Title

      炎症と免疫

      Volume: 20(1) Pages: 56-63

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] 膠原病の新しい風2011

    • Author(s)
      上阪等
    • Journal Title

      内科

      Volume: 107(4) Pages: 562-564

    • Data Source
      KAKENHI-PROJECT-23659377
  • [Journal Article] Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells2010

    • Author(s)
      Seki I, Suzuki M, Miyasaka, N, Kohsaka H
    • Journal Title

      Immunol Lett

      Volume: 129 Pages: 39-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] Current insights in polymyositis and dermatomyositis2010

    • Author(s)
      Kohsaka H
    • Journal Title

      Clin Exp Neuroimmnol

      Volume: 1 Pages: 22-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] Current insights in polymyositis and dermatomyositis2010

    • Author(s)
      Kohsaka H
    • Journal Title

      Clin Exp Neuroimmnol

      Volume: 1 Pages: 22-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Journal Article] Definitive engagement of cytotoxic CD8 T cells in C protein-induced myositis, a murine model of polymyositis.2010

    • Author(s)
      Sugihara, T., N.Okiyama, M.Suzuki, K.Kohyama, Y.Matsumoto, N.Mivasaka, H.Kohsaka
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 3088-3092

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Journal Article] Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells2010

    • Author(s)
      Seki, I., M.Suzuki, N.Miyasaka, H.Kohsaka.
    • Journal Title

      Immunol Lett

      Volume: 129 Pages: 39-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Journal Article] Intervention of an Inflammation Amplifier, Triggering Receptor Expressed on Myeloid Cells 1, for Treatment of Autoimmune Arthritis.2009

    • Author(s)
      Murakami Y, 他3名, Miyasaka N, Kohsaka H.
    • Journal Title

      Arthritis Rheum 60

      Pages: 1615-1623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] Hypoxia-induced Abrogation of Contact-dependent Inhibition of Rheumatoid Arthritis Synovial Fibroblast Proliferation2009

    • Author(s)
      Nonomura Y, Mizoguchi F, Suzuki A, Nanki T, Kato H, Miyasaka N, Kohsaka H.
    • Journal Title

      J Rheumatol 36

      Pages: 698-705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Hypoxia-induced Abrogation of Contact-dependent Inhibition of Rheumatoid Arthritis Synovial Fibroblast Proliferation2009

    • Author(s)
      Nonomura Y, Mizoguchi F, Suzuki A, Nanki T, Kato H, Miyasaka N, Kohsaka H
    • Journal Title

      J Rheumatol 36(4)

      Pages: 698-705

    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells2009

    • Author(s)
      Seki I, Suzuki M, Miyasaka, N, Kohsaka H.
    • Journal Title

      Immunol Lett 129

      Pages: 39-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] Hypoxia-induced Abrogation of Contact-dependent Inhibition of Rheumatoid Arthritis Synovial Fibroblast Proliferation2009

    • Author(s)
      Nonomura Y, Mizoguchi F, 他3名, Miyasaka N, Kohsaka H
    • Journal Title

      J Rheumatol 36

      Pages: 698-705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Journal Article] Successful treatment of animal models of rheumatoid arthritis with smallmolecule cyclin-dependent kinase inhibitors.2008

    • Author(s)
      Sekine C, Sugihara T, Miyake S, Hirai H, Yoshida M, Miyasaka N, Kohsaka H
    • Journal Title

      J Immunol 180

      Pages: 1954-1961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Successful treatment of animal models of rheumatoid arthritis with smallmolecule cyclin-dependent kinase inhibitors2008

    • Author(s)
      Sekine C, Sugihara T, Miyake S, Hirai H,Yoshida M, Miyasaka N, Kohsaka H
    • Journal Title

      J Immuno 180(3)

      Pages: 1954-61

    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous Prostaglandin E22007

    • Author(s)
      Murakami Y, Kohsaka H, Kitasato H, et al.
    • Journal Title

      J Immunol 178(2)

      Pages: 1144-1150

    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Lipopolysaccharide-induced up-regulation of triggering receptor expressedon myeloid cells-1 expression on macrophagesis regulated by endogenous Prostaglandin E22007

    • Author(s)
      Murakami Y, Kohsaka H, Kitasato H,and Akahoshi T
    • Journal Title

      J Immunol 178(2)

      Pages: 1144-1150

    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts2007

    • Author(s)
      Ohata J, Miura T, Hori S, Ziegler SF, Kohsaka H
    • Journal Title

      Arthritis Rheum 56(9)

      Pages: 2947-2956

    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Enhanced efficacy of regulatory T cell transfer by elevated Foxp3 expression against increasing resistance induced in arthritic hosts2007

    • Author(s)
      2. Ohata J, Miura T, Hori S, Ziegler SF, Kohsaka H.
    • Journal Title

      Arthritis Rheum. 56

      Pages: 2947-2956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591159
  • [Journal Article] A new murine model to define critical pathologic and therapeutic of polymyositis2007

    • Author(s)
      1. Sugihara T, Sekine C, Nakae T, Kohyama K, Harigai M, Iwakura Y, Matsumoto Y, Miyasaka N, Kohsaka H.
    • Journal Title

      Arthritis Rheum. 56

      Pages: 1304-1314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591159
  • [Journal Article] A new murine model to define critical pathologic and therapeutic of polymyositis2007

    • Author(s)
      Sugihara T, Sekine C, Nakae T, Kohyama K,Harigai M, Iwakura Y, Matsumoto Y, MiyasakaN, and Kohsaka H
    • Journal Title

      Arthritis Rheum 56(4)

      Pages: 1304-1314

    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts2007

    • Author(s)
      Ohata J, Miura T, Hori S, Ziegler SF, Kohsaka H
    • Journal Title

      Arthritis Rheum 56

      Pages: 2947-2956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Journal Article] Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoid inflammatory mediators in retinoblastoma protein-dependent and independent pathways2006

    • Author(s)
      Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori-Adachi M, Miyasaka, N, Kohsaka H
    • Journal Title

      Arthritis Rheum 54(7)

      Pages: 2074-2083

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/62006

    • Author(s)
      Y Nonomura, K Nagasaka, H Hagiyama, C Sekine, T Nanki, M Tamamori-Adachi, N Miyasaka, H Kohsaka
    • Journal Title

      Arthritis and Rheumatism 54(7)

      Pages: 2074-2083

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and-independent pathways by cyclin-dependent kinase 4/6.2006

    • Author(s)
      Tamamori-Adachi, N Miyasaka, H Kohsaka
    • Journal Title

      Arthritis and Rheumatism 54(7)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Inhibition of CX3CL1(Fractalkine) improves experimental autoimmune myositis in SJL/J mice.2005

    • Author(s)
      Suzuki F., Nanki T., Imai T., Kikuchi H., Hirohata S., Kohsaka H., Miyasaka N.
    • Journal Title

      J.Immunol 175(10)

      Pages: 6987-6996

    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Positional effect of amino acid replacement on peptide antigens for the increased IFN-gamma production from CD4 T cells.2005

    • Author(s)
      Liu T, Kohsaka H, Suzuki M, Takagi R, Hashimoto K, Uemura Y, Ohyama H, Matsushita S.
    • Journal Title

      Allergol Int 54(1)

      Pages: 117-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Positional effect of amino acid replacement on peptide antigens for the increased IFN-gamma production from CD4 T cells.2005

    • Author(s)
      Liu T, Kohsaka H, Suzuki M, Takagi R, Hashimoto K, Uemura Y, Ohyama H, Matsushita S
    • Journal Title

      Allergol Int 54(1)

      Pages: 117-122

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.2005

    • Author(s)
      Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, Miyasaka N
    • Journal Title

      J Immunol 175(10)

      Pages: 6987-6996

    • Data Source
      KAKENHI-PROJECT-17659299
  • [Journal Article] Positional effect of amino acid replacement on peptide antigens for the increased IFN-gamma production from CD4 T cells.2005

    • Author(s)
      Liu T, Kohsaka H, Suzuki M, Takagi R, Hashimoto K, Uemura Y, Ohyama H, Matsushita S
    • Journal Title

      Allergol Int 54(1)

      Pages: 117-122

    • Data Source
      KAKENHI-PROJECT-17659299
  • [Journal Article] Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.2005

    • Author(s)
      Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, Miyasaka N.
    • Journal Title

      J Immunol 175(10)

      Pages: 6987-6996

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.2005

    • Author(s)
      Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, Miyasaka N
    • Journal Title

      J Immunol 175(10)

      Pages: 6987-6996

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Development of TCRB CDR3 length repertoire of humanlymphocytes.2004

    • Author(s)
      Nishio J, Suzuki M, Nanki T, Miyasaka N, Kohsaka H
    • Journal Title

      Int Immunol 175.10

      Pages: 423-431

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390311
  • [Journal Article] Development of TCRB CDR3 length repertoire of human lymphocytes2004

    • Author(s)
      Nishio J, Suzuki M, Nanki T, Miyasaka N, Kohsaka H.
    • Journal Title

      Int Immunol 16(3)

      Pages: 423-431

    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Development of TCRB CDR3 length repertoire of human lymphocytes2004

    • Author(s)
      Nishio J, Kohsaka H et al.
    • Journal Title

      Int Immunol 16(3)

      Pages: 423-431

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Development of TCRB CDR3 length repertoire of human lymphocytes2004

    • Author(s)
      Nishio J, Suzuki M, Nanki T, Miyasaka N, Kohsaka H.
    • Journal Title

      Int Immunol 16(3)

      Pages: 423-431

    • Data Source
      KAKENHI-PROJECT-15390311
  • [Journal Article] Development of TCRB CDR3 length repertoire of human lymphocytes2004

    • Author(s)
      Nishio J, Suzuki M, Nanki T, Miyasaka N, Kohsaka H
    • Journal Title

      Int Immunol 16(3)

      Pages: 423-431

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390311
  • [Journal Article] Development of TCRB CDR3 length repertoire of human lymphocytes2004

    • Author(s)
      Nishio J, Suzuki M, Nanki T, Miyasaka N, Kohsaka H.
    • Journal Title

      Int Immunol 16(3)

      Pages: 423-431

    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis2003

    • Author(s)
      Nonomura Y, Kohsaka H et al.
    • Journal Title

      J Immunol 171(9)

      Pages: 4913-4919

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis.2003

    • Author(s)
      Nonomura Y, Kohsaka H, Nagasaka K, Miyasaka N.
    • Journal Title

      J.Immunol 171(9)

      Pages: 4913-4919

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis.2003

    • Author(s)
      Nonomura Y, Kohsaka H, Nagasaka K, Miyasaka N
    • Journal Title

      J Immunol 171(9)

      Pages: 4913-4919

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.2003

    • Author(s)
      Iwai H, Kohsaka H et al.
    • Journal Title

      J Immunol 171(9)

      Pages: 2848-2854

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Suppression of arthritis by forced expression of cyclin-dependent kinase Inhibitor p21 Cipl gene into the joints.2001

    • Author(s)
      Nonomura Y, Kohsaka.H, Nasu K, Terada Y, et al.
    • Journal Title

      Int Immunol 13(6)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Treatment of Arthritis with Cyclin-dependent Kinase Inhibitor Gene.2001

    • Author(s)
      Kohsaka H, Nasu K, Nonomura Y, Miyasaka N.
    • Journal Title

      Jpn J Clin Immunol 23(6)

      Pages: 550-552

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Treatment of Arthritis with Cyclin-dependent Kinase Inhibitor Gene2001

    • Author(s)
      Kohsaka H, Nasu K, Nonomura Y, Miyasaka N.
    • Journal Title

      Jpn J Clin Immunol 23(6)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Suppression of arthritis by forced expression of cyclin-dependent kinase Inhibitor p21^<Cip1> gene into the joints.2001

    • Author(s)
      Nonomura Y, Kohsaka H, Nasu K, Terada Y, Ikeda M, Miyasaka N.
    • Journal Title

      Int Immunol 13(6)

      Pages: 723-731

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Suppression of arthritis by forced expression of cyclin-dependent kinase Inhibitor p21 Cip1 gene into the joints.2001

    • Author(s)
      Nonomura Y, Kohsaka H, Nasu K, Terada Y, et al.
    • Journal Title

      Int Immuno1 13(6)

      Pages: 723-731

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Suppression of arthritis by forced expression of cyclin-dependent kinase Inhibitor p21^<Cipl> gene into the joints.2001

    • Author(s)
      Nonomura Y, Kohsaka H, Nasu K, Terada Y, Ikeda M, Miyasaka N
    • Journal Title

      Int Immunol 13(6)

      Pages: 723-731

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoi inflammatory mediators in retinoblastoma protein-dependent and independent pathways

    • Author(s)
      Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori-Adachi M, Miyasaka N, Kohsaka N.
    • Journal Title

      Arthritis Rheum. in press

    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Positional effect of amino acid replacement on peptide antigens for the increased IFN-gamma production from CD4 T cells

    • Author(s)
      Liu T, Kohsaka H, Suzuki M, et al.
    • Journal Title

      Allergol Int (in press)

    • Data Source
      KAKENHI-PROJECT-15390311
  • [Journal Article] Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoid inflammatory mediators in retinoblastoma protein-dependent and independent pathways

    • Author(s)
      Y Nonomura, K Nagasaka, H Hagiyama, C Sekine, T Nanki, M Tamamori-Adachi, N Miyasaka, H Kohsaka
    • Journal Title

      Arthritis and Rheumatism (In press)

    • Data Source
      KAKENHI-PROJECT-17390289
  • [Journal Article] Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoid inflammatory mediators in retinoblastoma protein-dependent and independent pathways

    • Author(s)
      Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori-Adachi M, Miyasaka N, Kohsaka H
    • Journal Title

      Arthritis Rheum (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Journal Article] Positional effect of amino acid replacement on peptide antigens for the increased IFN-gamma production from CD4 T cells

    • Author(s)
      Liu T, Kohsaka H, Suzuki M, et al.
    • Journal Title

      Allergol Int (in press)

    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoid inflammatory mediators in retinoblastoma protein-dependent and independent pathways

    • Author(s)
      Y Nonomura, K Nagasaka, H Hagiyama, C Sekine, T Nanki M Tamamori-Adachi, N Miyasaka, H Kohsaka
    • Journal Title

      Arthritis and Rheumatism In press

    • Data Source
      KAKENHI-PROJECT-13043012
  • [Journal Article] Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoid inflammatory mediators in retinoblastoma protein-dependent and independent pathways

    • Author(s)
      Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori-Adachi M, Miyasaka N, Kohsaka H.
    • Journal Title

      Arthritis Rheum. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Patent] 特発性炎症性筋疾患の予防又は治療剤2012

    • Inventor(s)
      上阪等
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2012-063595
    • Filing Date
      2012-03-21
    • Data Source
      KAKENHI-PROJECT-23659377
  • [Patent] 特発性炎症性筋疾患の予防又は治療剤2012

    • Inventor(s)
      上阪, 等
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2012-063595
    • Filing Date
      2012-03-21
    • Data Source
      KAKENHI-PROJECT-23659377
  • [Patent] 膠原病の予防・治療剤2008

    • Inventor(s)
      上阪等, 村上洋介
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2008-039292
    • Filing Date
      2008-02-20
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Patent] 抗関節リウマチ活性を有する物質のスクリーニング方法及び評価方法2006

    • Inventor(s)
      上阪 等, 宮坂 信之
    • Industrial Property Rights Holder
      医科歯科, 理研
    • Filing Date
      2006-02-20
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Patent] 滑膜細胞増殖抑制剤、並びにこれを利用した薬用組成物及び治療方法2006

    • Inventor(s)
      上阪 等
    • Industrial Property Rights Holder
      東京医科歯科大学・理研
    • Filing Date
      2006-02-20
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Patent] 抗関節リウマチ活性を有する物質のスクリーニング方法及び評価方法2006

    • Inventor(s)
      上阪等, 宮坂信之
    • Industrial Property Rights Holder
      医科歯科, 理研
    • Filing Date
      2006-02-20
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Patent] 抗リウマチ薬スクリーニング方法2006

    • Inventor(s)
      上阪ほか
    • Industrial Property Rights Holder
      医科歯科ほか
    • Filing Date
      2006-02-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Patent] 抗関節リウマチ活性を有する物質のスクリーニング方法及び評価方法2006

    • Inventor(s)
      上阪等, 宮坂信之
    • Industrial Property Rights Holder
      医科歯科, 理研
    • Filing Date
      2006-02-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Patent] 抗関節リウマチ活性を有する物質のスクリーニング方法及び評価方法。2006

    • Inventor(s)
      宮坂信之, 上阪 等
    • Industrial Property Rights Holder
      東京医科歯科大学 理化学研究所
    • Filing Date
      2006-02-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Patent] 滑膜細胞増殖抑制剤及び治療方法2006

    • Inventor(s)
      上阪ほか
    • Industrial Property Rights Holder
      医科歯科ほか
    • Filing Date
      2006-06-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Patent] 滑膜増殖抑制剤2005

    • Inventor(s)
      上阪 等, 宮坂 信之
    • Industrial Property Rights Holder
      医科歯科, 理研
    • Filing Date
      2005-07-18
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Patent] 滑膜細胞増殖抑制剤2005

    • Inventor(s)
      上阪ほか
    • Industrial Property Rights Holder
      医科歯科ほか
    • Filing Date
      2005-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390289
  • [Patent] 滑膜増殖抑制剤2005

    • Inventor(s)
      上阪等, 宮坂信之
    • Industrial Property Rights Holder
      医科歯科, 理研
    • Filing Date
      2005-07-18
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Patent] 滑膜細胞増殖抑制剤2005

    • Inventor(s)
      宮坂信之, 上阪 等
    • Industrial Property Rights Holder
      東京医科歯科大学 理化学研究所
    • Filing Date
      2005-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854014
  • [Patent] 滑膜増殖抑制剤2005

    • Inventor(s)
      上阪等, 宮坂信之
    • Industrial Property Rights Holder
      医科歯科, 理研
    • Filing Date
      2005-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13043012
  • [Presentation] 前脛骨筋を対象としたコンコトーム筋生検の有用性を示した多発性筋炎/ 皮膚筋炎の5例2017

    • Author(s)
      梅澤 夏佳、木村 直樹、上阪 等
    • Organizer
      第45回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] 多発性筋炎のin vitroモデルにおいて細胞傷害性Tリンパ球は非壊死筋細胞の内部に侵入し筋細胞死を誘導する2017

    • Author(s)
      神谷 麻理、木村 直樹、高村 聡人、溝口 史高、川畑 仁人、上阪 等
    • Organizer
      第4回JCRベーシックリサーチカンファレンス
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] 全身性エリテマトーデスで発症した遅発型複合免疫不全症の一例2017

    • Author(s)
      田中 奈緒、岡本 圭祐、今井 耕輔、梅澤 夏佳、溝口 史高、森尾 友宏、上阪 等
    • Organizer
      第28回日本リウマチ学会関東支部学術集会
    • Data Source
      KAKENHI-PROJECT-16K15512
  • [Presentation] 多発性筋炎における細胞傷害性T細胞による筋傷害のin vitro解析2017

    • Author(s)
      神谷 麻理、木村 直樹、高村 聡人、川畑 仁人、上阪 等
    • Organizer
      第3回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] Study of in vitro T cell/myotube interaction disclosed invasive and cytotoxic nature of CD8+ cells enclosed in the muscle cells.2017

    • Author(s)
      Mari Kamiya, Naoki Kimura, Akito Takamura, Fumitaka Mizoguchi, Kimito Kawahata, Hitoshi Kohsaka
    • Organizer
      19th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] 多発性筋炎における細胞傷害性 T 細胞による筋傷害のin vitro 解析2017

    • Author(s)
      神谷 麻理、木村 直樹、高村 聡人、溝口 史高、川畑 仁人、上阪 等
    • Organizer
      第45回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] Abnormal composition of circulating T and B cells in patients with polymyositis and dermatomyositis is more biased in those with interstitial lung diseases2016

    • Author(s)
      Hirokazu Sasaki, Akito Takamura, Kimito Kawahata and Hitoshi Kohsaka
    • Organizer
      American College of Rheumatology 80th National Meeting
    • Place of Presentation
      Washington, DC
    • Year and Date
      2016-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] Altered Peripheral lymphocyte subset repertores that reflect clinical features of dermatomyositis and polymyositis2016

    • Author(s)
      Hirokazu Sasaki, Akito Takamura, Kimito Kawahata, Hitoshi Kohsaka
    • Organizer
      13th International Workshop on Autoantibodies and Autoimmunity
    • Place of Presentation
      Westin Miyako Hotel Kyoto(Kyoto,Kyoto)
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] ヒトiPS細胞由来筋細胞は筋芽細胞同様に筋炎を増悪し得るサイトカインを産生する2015

    • Author(s)
      長谷川 久紀、川畑 仁人、髙木 春奈、大津 真、上阪 等
    • Organizer
      第1回日本筋学会学術集
    • Place of Presentation
      国立精神・神経医療研究センター神経研究所(東京都・小平市)
    • Year and Date
      2015-08-08
    • Data Source
      KAKENHI-PROJECT-26670474
  • [Presentation] ヒト人工多能性幹細胞由来の筋細胞は再生筋線維と同様のサイトカイン産生能をもつ2015

    • Author(s)
      長谷川 久紀、川畑 仁人、髙木 春奈、大津 真、上阪 等
    • Organizer
      第43回日本臨床免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-10-23
    • Data Source
      KAKENHI-PROJECT-26670474
  • [Presentation] Injury And Subsequent Regeneration Of Muscles Activate Local Innate Immunity To Facilitate Development And Relapse Of Autoimmune Myositis2015

    • Author(s)
      Naoki Kimura, Shinya Hirata, Nobuyuki Miyasaka, Kimito Kawahata, Hitoshi Kohsaka
    • Organizer
      1st International Conference on Myositis
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2015-05-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] Interferon-gamma but not interleukin-4 restrains experimental myositis2015

    • Author(s)
      Yoko Yoshihashi-Nakazato, Kimito Kawahata, Naoki Kimura, Hitoshi Kohsaka
    • Organizer
      1st International Conference on Myositis
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2015-05-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04863
  • [Presentation] ヒトiPS細胞由来筋細胞は筋芽細胞同様に筋炎を増悪し得るサイトカインを産生する2015

    • Author(s)
      長谷川 久紀、川畑 仁人、髙木 春奈、大津 真、上阪 等
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-26670474
  • [Presentation] 多発性筋炎における抗サイトカイン治療の標的-Seed and Soil Model-2011

    • Author(s)
      上阪等、木村直樹、沖山奈緒子、宮坂信之
    • Organizer
      第39回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659377
  • [Presentation] TREM-1リガンドの同定とモノクローナル抗体による新規関節炎治療法の開発2011

    • Author(s)
      岩井秀之、細矢匡、村上洋介、宮坂信之、上阪等
    • Organizer
      第39回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] Identification of TREM-1 ligand and development of new anti-rheumatic therapies with monoclonal antibody2011

    • Author(s)
      Hideyuki Iwai, Tadashi Hosoya, Yousuke Murakami, Nobuyuki Miyasaka, Hitoshi Kohsaka
    • Organizer
      East Asian Group of Rheumatology Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] リウマチ治療の新戦略を求めて2011

    • Author(s)
      上阪等、細矢匡、岩井秀之、村上洋介、宮坂信之
    • Organizer
      第39回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] 関節リウマチのサイクリン依存症キナーゼ4/6阻害療法2011

    • Author(s)
      上阪等、細矢匡、岩井秀之、宮坂信之
    • Organizer
      第55回日本リウマチ学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] 宮坂信之多発性筋炎における抗サイトカイン治療の標的-Seed and Soil Model-2011

    • Author(s)
      上阪等、木村直樹、沖山奈緒子
    • Organizer
      第39回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659377
  • [Presentation] 関節炎治療標的としてのB細胞上のTREM-1リガンドの同定2011

    • Author(s)
      岩井秀之、細矢匡、村上洋介、宮坂信之、上阪等
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] Proinflammatory muscle fiber regeneration in autoimmune myositis2011

    • Author(s)
      Kimura N, Hirata S, Maeda A, Miyasaka N, Kohsaka H
    • Organizer
      Gordon Research Conference on Myogenesis
    • Place of Presentation
      Waterville Valley
    • Data Source
      KAKENHI-PROJECT-23659377
  • [Presentation] 多発性筋炎と皮膚筋炎-膠原病内科医の診ため-2010

    • Author(s)
      上阪等
    • Organizer
      2010北海道末梢神経・筋研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-31
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Presentation] p16INK4a exerts anti-inflammatory effects through acceleration of IRAK1 degradation in macrophages2010

    • Author(s)
      Hitoshi Kohsaka, Yousuke Murakami, Fumitaka Mizoguchi, Nobuyuki Miyasaka
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Osaka
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] 多発性筋炎・皮膚筋炎研究-静から動へ-2010

    • Author(s)
      上阪等
    • Organizer
      順天堂大学膠原病内科講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-30
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Presentation] Autoagressive T cells and inflammatory cytokines in autoimmune myositis.2010

    • Author(s)
      Kohsaka H
    • Organizer
      6th Annual Symposium at Rheumatism Research Institute
    • Place of Presentation
      Seoul
    • Year and Date
      2010-06-02
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Presentation] サイクリン依存性キナーゼ阻害薬2010

    • Author(s)
      上阪等、村上洋介、宮坂信之
    • Organizer
      第31回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] 筋炎における自己反応性T細胞と炎症性サイトカイン2010

    • Author(s)
      上阪等
    • Organizer
      第6回自己免疫疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-03
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Presentation] 膠原病内科医から見た炎症性筋疾患の基礎と臨床2010

    • Author(s)
      上阪等
    • Organizer
      第17回熊本神経カンファレンス
    • Place of Presentation
      熊本
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-22659140
  • [Presentation] miR-31 contributes to the optimal bone resorption by osteoclasts2010

    • Author(s)
      Fumitaka Mizoguchi, Yousuke Murakami, Nobuyuki Miyasaka, Hitoshi Kohsaka
    • Organizer
      3^<rd> International Conference on Osteoimmunology
    • Place of Presentation
      Santorini
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] Beyond Immunosuppressive Treatments of Rheumatoid Arthritis2009

    • Author(s)
      上阪, 等
    • Organizer
      9^<th> World Congress on Inflammation
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] 新たな発想による次世代抗リウマチ薬の開発2009

    • Author(s)
      上阪, 等
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-21249060
  • [Presentation] リウマチ滑膜線維芽細胞におけるlet-7 microRNAの効果2008

    • Author(s)
      中里款, 宮坂信之, 上阪等
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 関節炎抑制のために制御性T細胞に必要な抗原特異性と免疫抑制性2008

    • Author(s)
      上阪等、大畑順子
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      学術集会札幌
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 宮坂信之関節リウマチ治療の新たな標的分子2008

    • Author(s)
      上阪等、村上洋介、野々村美紀
    • Organizer
      日本臨床分子医学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 関節リウマチ治療の新たな標的分子2008

    • Author(s)
      上阪等, 村上洋介, 野々村美紀, 宮坂信之
    • Organizer
      第45回日本臨床分子医学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] E3ユビキチンリガーゼc-MIRの抗炎症効果による関節炎治療2008

    • Author(s)
      豊本雅靖、石戸聡、宮坂信之、上阪等
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] Osteoclast Specific Dicer Deficiency Suppress Osteoclast Differentiation And Increase Bone Mass2008

    • Author(s)
      Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, Nakamura T, Kohsaka H,Miyasaka N, Harfe B, Kato S, Ezura Y, Noda M
    • Organizer
      2nd International Conference on Osteoimmunology
    • Place of Presentation
      Rhodes,Greece
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] マウスのコラーゲン誘発性関節炎と破骨細胞に対するドパミン受容体阻害薬の効果2008

    • Author(s)
      中塩屋大樹、宮坂信之、松下祥、上阪等
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 関節リウマチの新しい標的分子Triggering receptorexpressed on myeloid cells-12008

    • Author(s)
      村上洋介、宮坂信之、上阪等
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 関節炎治療の新たな標的分子Triggering receptor expressed on myeloid cells-1(TREM-1)2008

    • Author(s)
      村上洋介, 赤星透, 宮坂信之, 上阪等
    • Organizer
      第52回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] Osteoclast Specific Dicer Deficiency Suppress Osteoclast Differentiation And Increase Bone Mass2008

    • Author(s)
      Mizoguchi F, Izu Y, Hayata T , Hemmi H, Nakashima K, Nakamura T, Kohsaka H, Miyasaka N, Harfe B, Kato S, Ezura Y, Noda M.
    • Organizer
      2nd International Conference on Osteoimmunology
    • Place of Presentation
      Greece
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] Takao Koike A 2 Year-ExtendedFollow-Up Of The Phase I/Ii Trial Of Rituximab For Treatment Of Refractory Systemic Lupus Erythematosus2008

    • Author(s)
      Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Nnorihiro Nishimoto, Nobuyuki Miyasaka, T Sumida, Tetsuji Sawada, Hitoshi Kohsaka, Isao Matsumoto, K. Saito
    • Organizer
      AnnualEuropean Congress of Rheumatology EULAR
    • Place of Presentation
      Paris France
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] リウマチ滑膜線維芽細胞におけるlet-7microRNAの効果2008

    • Author(s)
      中里款、宮坂信之、上阪等
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] E3ユビクチンリガーゼc-MIRの抗炎症効果による関節炎治療2008

    • Author(s)
      豊本雅靖、石戸聡、宮坂信之、上阪等
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] Preparation of a TAT-PTD CDKI FusionProtein that efficiently InhibitsProliferation and MMP-3 Production ofRheumatoid Synovial Fibroblasts2007

    • Author(s)
      Makoto Nakasato, Yoshinori Nonomura, Nobuyuki Miyasaka, Hitoshi Kohsaka
    • Organizer
      AmericanCollege of Rheumatology 71th National Meetings
    • Place of Presentation
      Boston, MA
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] TAT-PTDを用いたリコンビナントCDKIタンパクの関節リウマチ滑膜線維芽細胞への導入2007

    • Author(s)
      中里款, 野々村美紀, 宮坂信之, 上阪等
    • Organizer
      第35回臨床免疫学会総会(ワークショップ)
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 細胞膜透過型タンパク製剤を用いた新規抗リウマチ療法の研究(ワークショップ)2007

    • Author(s)
      中里款、野々村美紀、宮坂信之、上阪等
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] CDK4/6阻害薬による関節炎治療2007

    • Author(s)
      上阪 等、野々村美紀、村上洋介、関根知世子、宮坂信之
    • Organizer
      第51回日本リウマチ学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] CDK4/6阻害薬による関節炎治療2007

    • Author(s)
      上阪等、野々村美紀、村上洋介、関根知世子、宮坂信之
    • Organizer
      第51回日本リウマチ学会総会上阪
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] 宮坂信之CDK4/6 を標的とした関節炎治療(ワークショップ)2007

    • Author(s)
      上阪等、野々村美紀、村上洋介、関根知世子
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] PGE2を介したLPSによるTREM-1発現の制御機構2007

    • Author(s)
      村上洋介、上阪等、赤星透
    • Organizer
      第16回内毒素・LPS研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-23
    • Data Source
      KAKENHI-PROJECT-19390272
  • [Presentation] ヒトiPS細胞由来筋細胞は筋芽細胞同様に多発性筋炎/皮膚筋炎を増悪し得るサイトカインを産生する能をもつ

    • Author(s)
      長谷川 久紀、川畑 仁人、髙木 春奈、大津 真、上阪 等
    • Organizer
      第59回日本リウマチ学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-23 – 2015-04-25
    • Data Source
      KAKENHI-PROJECT-26670474
  • 1.  MIYASAKA Nobuyuki (30157622)
    # of Collaborated Projects: 18 results
    # of Collaborated Products: 54 results
  • 2.  TSUBATA Takeshi (80197756)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  TERADA Yoshio (30251531)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  三浦 修 (10209710)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  野々村 美紀 (30392070)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 6.  RAJEWSKY Klaus
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SASANO Minoru
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MATSUSHITA Sho (50167649)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  HIGASHI Takehiro (00468381)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  AWATA Takuya (40184303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OKADA Hirokazu (60233342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SIMOJYO Naoki (40221303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KONDO Shigeru (10252503)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  AIBA Yuichi (00273516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KITAMURA Daisuke (70204914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  ADACHI Takahiro (50222625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  杉本 八郎 (90362574)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  溝口 史高 (60510360)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 19.  仲野 徹 (00172370)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  LEDERMAN Seth
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  CLARK Edward A
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  RETH Michael
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TANAKA Nao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  SATO Motohiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  HOWARD Maure
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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