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NAKASIMA Mikiro  中嶋 幹郎

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NAKASHIMA Mikiro  中嶋 幹郎

中嶋 幹郎  ナカシマ ミキロウ

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Researcher Number 00260737
Other IDs
Affiliation (Current) 2025: 長崎大学, 医歯薬学総合研究科(薬学系), 教授
Affiliation (based on the past Project Information) *help 2014 – 2023: 長崎大学, 医歯薬学総合研究科(薬学系), 教授
2011 – 2013: 長崎大学, 医歯(薬)学総合研究科, 教授
2008 – 2010: Nagasaki University, 大学院・医歯薬学総合研究科, 教授
2006: Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授
2005: Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 … More
2004: 長崎大学, 歯学部附属病院, 助教授
2003 – 2004: Nagasaki University Hospital of Medicine and Dentistry, Department of Hospital Pharmacy, Associate Professor, 医学部・歯学部附属病院, 助教授
2002: Nagasaki University, School of Medicine, Department of Hospital Pharmacy, Associate Professor, 医学部附属病院, 助教授
2001: 長崎大学, 医学部・附属病院, 助教授
1998 – 1999: 長崎大学, 医学部・附属病院, 助手
1997: 長崎大学, 医学部附属病院, 助手
1994 – 1995: 長崎大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学
Except Principal Investigator
Medical pharmacy / Physical pharmacy / Medium-sized Section 58:Society medicine, nursing, and related fields / Physical pharmacy / 医薬分子機能学
Keywords
Principal Investigator
トキシコゲノミクス / 後発医薬品 / T-LEX / ヒト肝細胞キメラマウス / 薬剤性肝障害 / 薬剤反応性 / 品質試験 / シクロスポリン / マイクロダイアリシス / エピトープ … More / 腫瘍関連抗原 / 膀胱癌 / がん免疫療法 / 効果予測 / 抗原エピトープ / 免疫複合体 / 免疫チェックポイント阻害剤 / 肝線維化抑制効果 / T-LEX 法 / スクリーニング / 創薬 / 肝臓線維化抑制効果 / ドラッグリポジショニング / T-LEX / 製剤品質評価 / ファーマコビジランス / ヒト肝キメラマウス / 安全性試験 / 薬剤仮応性 / 動物実験 / セロミクス / 薬剤応答性 / 毒性試験 / 安全性学 / 医薬品情報 / 点眼液 / 房水 / 角膜透過 / 吸収促進剤 / 経皮吸収 … More
Except Principal Investigator
肝臓 / 薬物送達 / 薬物速度論 / Drug delivery system / intraperitoneal administration / liver disease / anticancer drug / liver / 吸収速度 / 腹腔内投与 / 抗癌薬 / Anticancer agent / 5-Fluorouracil / Drug targeting / Liver / 抗癌剤 / 制癌剤 / DDS / 5-fluorouracil / 速度論 / 眼 / バイオマーカー / 精神疾患 / 視える化 / Gene / Cancer / Pharmacy / 遺伝子 / 癌 / 薬学 / pharmacokinetics / drug interaction / 粘性 / 肝障害 / 薬物相互作用 / Clinical application / Pharmacokinetics / Ophthalmology / Polymer / Liposomes / Gene delivery / Topical application / ベクター / 動態 / 局所 / 臨床応用 / 眼科 / 高分子 / リポソーム / 遺伝子治療 / 局所適用 / oharmacokinetics / absorption rate / 肝疾患 / Cancer chemotherapy / Rat / Liver surface application / 癌化学療法 / ラット / 肝臓表面投与 / ADEQUATE MEDICATION-USE / DRUG DISPOSITION / DIFFUSION / PHARMACOKINETICS / MEMBRANE PENETRATION / PHARMACOTHERAPY / DRUG DELIVERY / EYE / 適正化 / 薬物動態 / 拡散 / 膜透過 / 薬物治療 Less
  • Research Projects

    (15 results)
  • Research Products

    (53 results)
  • Co-Researchers

    (18 People)
  •  Challenge to "visualize mental illness" to realize a symbiotic society with illness

    • Principal Investigator
      大山 要
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Nagasaki University
  •  Basic development of highly directed cancer immunotherapy targeting bladder cancer-specific antigens and epitopesPrincipal Investigator

    • Principal Investigator
      中嶋 幹郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Nagasaki University
  •  Development of cancer immunotherapy pinpointing tumor cells of lung adenocarcinomaPrincipal Investigator

    • Principal Investigator
      Nakashima Mikiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Nagasaki University
  •  Development of drug discovery method to increase the success rate of drug repositioning drug discoveryPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Mikiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University
  •  Study of risk assessment of drug-induced liver injury using chimeric mice with highly humanized liver and large-scale adverse drug reactions databesePrincipal Investigator

    • Principal Investigator
      NAKASHIMA Mikiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University
  •  Development of a system to predict the bioequivalency of risk of drug-induced hepatotoxicity in humans in the case of using generic and counterpart drug formulationsPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Mikiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University
  •  Study on evaluation system for drug cardiotoxicity using on-chip cell-besed analysis and quality examination of generic products of injectionPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Mikiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University
  •  Development of liver surface administration for the selective delivery of anticancer agent to the cancer region

    • Principal Investigator
      NAKAMURA Junzo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University
  •  Development of liver surface application form of anticancer drugs and genome medicine aiming to specific therapy of the diseased region in the organ

    • Principal Investigator
      NISHIDA Koyo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagasaki University
  •  Development of topical gene delivery system for clinical application

    • Principal Investigator
      SASAKI Hitoshi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagasaki University Hospital of Medicine and Dentistry
  •  Targeting of anticancer drugs and genome medicine by utilizing absorption from the liver surface

    • Principal Investigator
      NISHIDA Koyo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagasaki University
  •  Liver-selective delivery of 5-fluorouracil utilizing the absorption on the liver surface in rats

    • Principal Investigator
      NAKAMURA Junzo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagasaki University
  •  PHARMACOKINETIC ANALYSIS FOR ADEQUATE MEDICATION-USE IN OPHTHALMOLOGY

    • Principal Investigator
      SASAKI Hitoshi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      NAGASAKI UNIVERSITY HOSPITAL, SCHOOL OF MEDICINE
  •  マイクロダイアリシスシステムを用いた薬物のin vivo角膜透過に関する研究Principal Investigator

    • Principal Investigator
      中嶋 幹郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Nagasaki University
  •  マイクロダイアリシスシステムを用いた薬物のin vivo経皮吸収に関する研究Principal Investigator

    • Principal Investigator
      中嶋 幹郎
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Nagasaki University

All 2022 2020 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2005 2004 2003 Other

All Journal Article Presentation Patent

  • [Journal Article] Immune complexome analysis of serum samples from non-small-cell lung cancer patients identifies predictive biomarkers for nivolumab therapy2022

    • Author(s)
      Aizawa Rika、Nakamura Yoichi、Ikeda Takaya、Aibara Nozomi、Kutsuna Yuki J.、Kurosaki Tomoaki、Aki Keisei、Junya Hashizume、Nakagawa Hiroo、Sato Kayoko、Kodama Yukinobu、Nakashima Mihoko N.、Nakashima Mikiro、Mukae Hiroshi、Ohyama Kaname
    • Journal Title

      Clinica Chimica Acta

      Volume: 532 Pages: 84-88

    • DOI

      10.1016/j.cca.2022.05.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07177
  • [Journal Article] Optimization of pH Elution Conditions in Immune Complexome Analysis for Comprehensive Identification of Immune Complex Antigens2020

    • Author(s)
      AIBARA Nozomi、AIZAWA Rika、NAKASHIMA Mikiro、OHYAMA Kaname
    • Journal Title

      Analytical Sciences

      Volume: 36 Pages: 1423-1426

    • NAID

      130007937700

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07177
  • [Journal Article] 後発医薬品の信頼性向上の取組として開発された T-LEX 法2017

    • Author(s)
      中嶋幹郎、大山 要
    • Journal Title

      ファルマシア

      Volume: 53 Pages: 787-789

    • Data Source
      KAKENHI-PROJECT-17K08448
  • [Journal Article] Transcriptome analysis of human liver on chimeric PXB-Mouse for risk marker identification associated with drug-induced liver injury2016

    • Author(s)
      H. Enomoto, H. Tachiki, T. Shimada, S. Nagatsuka, M. Nakashima
    • Journal Title

      Toxicology Letters

      Volume: 258S

    • Data Source
      KAKENHI-PROJECT-26460220
  • [Journal Article] Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse with highly humanized liver2014

    • Author(s)
      MIKIRO NAKASHIMA et al
    • Journal Title

      Toxicology Letters

      Volume: 229S

    • Data Source
      KAKENHI-PROJECT-26460220
  • [Journal Article] Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-mouse with highly humanized liver2013

    • Author(s)
      Mikiro Nakashima、Hidehisa Tachiki、Hatsune Enomoto、Takashi Shimada、Shin-Ichiro Nagatsuka
    • Journal Title

      Toxicology Letters

      Volume: 221

    • Data Source
      KAKENHI-PROJECT-23590187
  • [Journal Article] Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse with highly humanized liver2013

    • Author(s)
      Mikiro Nakashima, Hidehisa Tachiki, Hatsune Enomoto, Takashi Shimada, Shin-Ichiro Nagatsuka
    • Journal Title

      Toxicology Letters

      Volume: 221

    • Data Source
      KAKENHI-PROJECT-23590187
  • [Journal Article] オンチップ心筋拍動細胞ネットワークを用いた抗不整脈薬の薬物応答性の解析2008

    • Author(s)
      中嶋幹郎
    • Journal Title

      長崎医学会雑誌 83

      Pages: 59-66

    • NAID

      110007148533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590147
  • [Journal Article] オンチップ心筋拍動細胞ネットワークを用いた抗不整脈薬の薬物応答性の解析2008

    • Author(s)
      中嶋幹郎、大脇裕一、向江俊彦、梅野繁智、柳原克紀、河野茂、冨永留美、荒木良介、寺薗英之、北原隆志、藤秀人、佐々木均
    • Journal Title

      長崎医学会雑誌 83

      Pages: 59-66

    • NAID

      110007148533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590147
  • [Journal Article] Unilateral kidney-selective gene transfer following the administration of naked plasmid DNA to the kidney surface in mice2005

    • Author(s)
      Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura et al.
    • Journal Title

      Biological & Pharmaceutical Bulletin 28

      Pages: 181-184

    • NAID

      110003665796

    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] Effect of solution composition of plasmid DNA on gene transfection following liver surface administration in mice.2005

    • Author(s)
      R.Hirayama, S.Fumoto, K.Nishida, M.Nakashima, H.Sasaki, J.Nakamura
    • Journal Title

      Biol. Pharm. Bull. 28

      Pages: 2166-2169

    • NAID

      110003666420

    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] Delivery advantage to the unilateral kedney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model.2005

    • Author(s)
      K.Nishida, M, Kamenosono, A, Kuma, S.Fumoto, T.Mukai, M.Nakashima, H.Sasaki, J.Nakamura
    • Journal Title

      Journal of Drug Targeting 13

      Pages: 215-223

    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] Mechanism of permeability-enhancing effect of EDTA and bolic acid on the corneal penetration of 4-[1-hydroxy-1-methylethyl]-2-propyl-1-[4-[2-[tetrazole-5-yl]phenyl]phenyl]methylimidazole-5-carboxylic acid monohydrate (CS-088).2005

    • Author(s)
      T.Kikuchi, M.Suzuki, A.Kusai, K.Iseki, H.Sasaki, K.Nakashima
    • Journal Title

      Int. J. Pharmaceu. 290

      Pages: 107-114

    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] Unilateral kidney-selective gene transfer following the administration of naked plasmid DNA to the kidney surface in mice.2005

    • Author(s)
      R.Hirayama, K.Nishida, S.Fumoto, M, Nakashima, H.Sasaki, J.Nakamura
    • Journal Title

      Biol. Pharm. Bull. 28

      Pages: 181-184

    • NAID

      110003665796

    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] Prednisolone retention in integrated liposomes by chemical approach and pharmaceutical approach2004

    • Author(s)
      Mugen Teshima, Mikiro Nakashima, Hitoshi Sasaki et al.
    • Journal Title

      Journal of Controlled Release 97

      Pages: 211-218

    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] One-side-coated insert as a unique ophthalmic drug delivery system2003

    • Author(s)
      Hitoshi Sasaki, Koyo Nishida, Mikiro Nakashima et al.
    • Journal Title

      Journal of Controlled Release, 92-3

      Pages: 241-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590133
  • [Journal Article] One-side-coated insert as a unique ophthalmic drug delivery system2003

    • Author(s)
      Hitoshi Sasaki, Koyo Nishida, Mikiro Nakashima et al.
    • Journal Title

      Journal of Controlled Release 92・3

      Pages: 241-247

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590133
  • [Patent] T-LEX2013

    • Inventor(s)
      中嶋幹郎、東和薬品株式会社
    • Industrial Property Rights Holder
      中嶋幹郎、東和薬品株式会社
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-09-27
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Patent] T-LEX2013

    • Inventor(s)
      中嶋幹郎、東和薬品
    • Industrial Property Rights Holder
      中嶋幹郎、東和薬品
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-12
    • Acquisition Date
      2013-09-27
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Patent] T-LEX2013

    • Inventor(s)
      中嶋幹郎、東和薬品株式会社
    • Industrial Property Rights Holder
      中嶋幹郎、東和薬品株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-12
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Patent] T-LEX2013

    • Inventor(s)
      中嶋幹郎、東和薬品
    • Industrial Property Rights Holder
      中嶋幹郎、東和薬品
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-12
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] Selective, sensitive and comprehensive detection of immune complex antigens for discovering disease-specific antigens2020

    • Author(s)
      N. Aibara, M. Nakashima, N. Kuroda, K. Ohyama
    • Organizer
      68th ASMS 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07177
  • [Presentation] Reliable screening for drug repositioning study against liver disease and toxicology by gene expression analysis of a model mouse transplented with human liver2017

    • Author(s)
      K. Ohyama, H. Soki, H. Miyamoto, H. Enomoto, H. Tachiki, S. Nagatsuka, M. N. Nakashima, M. Nakashima
    • Organizer
      第56回国際毒性学会(国際学会)
    • Place of Presentation
      ボルチモア(米国)
    • Year and Date
      2017-03-12
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] ヒト肝細胞キメラマウスの遺伝子発現解析による肝疾患治療薬のドラッグリポジショニング的探索研究2016

    • Author(s)
      大山 要、曽木洋志、榎本初音、立木秀尚、宮元敬天、中嶋弥穂子、中嶋幹郎
    • Organizer
      第26回日本医療薬学会年会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] 薬学教育における「ジェネリック医薬品の安全性・副作用情報ビデオ」の効果の検証2015

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      日本ジェネリック医薬品学会第9回学術大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-06-13
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] T-LEX法を用いたジェネリック医薬品の肝障害リスク予測に関する研究2014

    • Author(s)
      中嶋幹郎、江頭かの子、大脇裕一、榎本初音、立木秀尚、島田卓、長塚伸一郎、中嶋弥穂子
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学黒髪キャンパス(熊本市)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)によるモサプリドクエン酸塩錠の先発医薬品・ジェネリック医薬品の比較研究2013

    • Author(s)
      中嶋幹郎
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse with highly humanized liver2013

    • Author(s)
      Mikiro Nakashima, Hidehisa Tachiki, Hatsune Enomoto, Takashi Shimada, Shin-Ichiro Nagatsuka
    • Organizer
      第49回欧州トキシコロジー学会
    • Place of Presentation
      インターラーケン(スイス)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)と臨床での肝障害発現頻度の比較研究2013

    • Author(s)
      榎本初音、立木秀尚、島田卓、長塚伸一郎、中嶋幹郎
    • Organizer
      第34回日本臨床薬理学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規な薬剤性ヒト肝障害リスク予測法(T-LEX法)による医薬品添加剤のヒト肝障害リスクへの影響予測2013

    • Author(s)
      立木秀尚、榎本初音、島田卓、長塚伸一郎、中嶋幹郎
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)によるモサプリドクエン酸塩錠の先発医薬品・ジェネリック医薬品の比較研究2013

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)の開発(1)~ジェネリック医薬品による有用性の検討~2013

    • Author(s)
      中嶋幹郎、江頭かの子、中嶋弥穂子、島田卓、長塚伸一郎、榎本初音、立木秀尚
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)の開発(2)~ジェネリック医薬品の品質評価への応用~2013

    • Author(s)
      榎本初音、立木秀尚、島田卓、長塚伸一郎、中嶋弥穂子、江頭かの子、中嶋幹郎
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)の開発(1)~ジェネリック医薬品による有用性の検討~2013

    • Author(s)
      中嶋幹郎
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)の開発とアトルバスタチン錠ジェネリック医薬品の品質評価への応用2013

    • Author(s)
      中嶋幹郎、江頭かの子、中嶋弥穂子、島田卓、長塚伸一郎、榎本初音、立木秀尚
    • Organizer
      日本ジェネリック医薬品学会第7回学術大会
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都品川区)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 新規薬剤性ヒト肝障害リスク予測法(T-LEX法)の開発とアトルバスタチン錠ジェネリック医薬品の品質試験への応用2013

    • Author(s)
      中嶋幹郎
    • Organizer
      日本ジェネリック医薬品学会第7回学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] ヒト肝細胞キメラマウスを用いたアトルバスタチン錠の薬剤性肝障害リスク予測に関する研究2012

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      第6回日本ジェネリック医薬品学会学術大会
    • Place of Presentation
      品川区総合区民会館きゅりあん(東京都)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] ヒト肝細胞キメラマウスとトキシコゲノミクスの手法を用いたアトルバスタチン錠「トーワ」のヒト肝障害リスクの予測~リポトール錠との比較~2012

    • Author(s)
      榎本初音、中嶋幹郎 ら
    • Organizer
      第33回日本臨床薬理学会学術総会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] Evaluation of hepatotoxic equivalency by comparing changes in hepatic gene expression induced by two different formulations of atorvastatin in chimeric PXB-mouse with highly humanized liver2012

    • Author(s)
      Mikiro Nakashima
    • Organizer
      51 st Annual Meeting of Society of Toxicology
    • Place of Presentation
      San Francisco、USA
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] ヒト肝細胞キメラマウスを用いたアトルバスタチン錠の薬剤性肝障害リスク予測に関する研究2012

    • Author(s)
      中嶋幹郎
    • Organizer
      日本ジェネリック医薬品学会第6回学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 同一有効成分の医薬品適用時における薬剤性肝障害のリスク予測法に関する研究2011

    • Author(s)
      中嶋幹郎
    • Organizer
      日本ジェネリック医薬品学会第5回学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 注射薬の後発医薬品に関する品質及び安全性の評価2010

    • Author(s)
      中嶋幹郎
    • Organizer
      第4回日本ジェネリック医薬品学会学術大会
    • Place of Presentation
      さいたま市
    • Data Source
      KAKENHI-PROJECT-20590147
  • [Presentation] 注射薬の後発医薬品に関する品質及び安全性の評価2010

    • Author(s)
      中嶋幹郎、荒木良介、中嶋弥穂子、中村純三、佐々木均、八坂貴宏
    • Organizer
      第4回日本ジェネリック医薬品学会学術大会
    • Place of Presentation
      さいたま
    • Data Source
      KAKENHI-PROJECT-20590147
  • [Presentation] 市販注射薬の先発医薬品と後発医薬品における同等性の検討(2):塩酸リトドリン注射薬の品質比較2009

    • Author(s)
      荒木良介、八坂貴宏、藤井貴玄、田中栄美、向江俊彦、大脇裕一、西田孝洋、中村純三、中嶋弥穂子、中嶋幹郎
    • Organizer
      第26回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20590147
  • [Presentation] Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse with highly humanized live

    • Author(s)
      MIKIRO NAKASHIMA et al
    • Organizer
      第50回欧州トキシコロジー学会
    • Place of Presentation
      EICC (エジンバラ:英国)
    • Year and Date
      2014-09-07 – 2014-09-10
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] Effects of antiarrhythmic agents on beating rhythm of cultured cardiomyocyte networks on an agarose microchamber chip

    • Author(s)
      Ohwaki Y、Araki R、Tominaga R、Terazono H、To H、Sasaki H、Nakashima M
    • Organizer
      The Second Asian Symposium on Pharmaceutical Sciences
    • Place of Presentation
      Nagasaki,、Japan
    • Data Source
      KAKENHI-PROJECT-20590147
  • [Presentation] ヒト肝細胞キメラマウスを用いたバラシクロビル製剤のヒト肝臓遺伝子発現への影響解析

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      第24回日本医療薬学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-09-27 – 2014-09-28
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] T-LEX法による薬剤性ヒト肝障害リスク予測データと臨床での薬剤性肝障害発生頻度データとの比較解析

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      日本ジェネリック医薬品学会第8回学術大会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Year and Date
      2014-07-12 – 2014-07-13
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] T-LEX法を用いたジェネリック医薬品のヒト肝障害リスク予測に関する研究

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      第47回日本薬剤師会学術大会
    • Place of Presentation
      山形市民会館(山形県山形市)
    • Year and Date
      2014-10-12 – 2014-10-13
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] Changes in Hepatic Gene Expression Induced by Two Different Formulations of Atrvastatin in Chimeric PXB―mouse with Highly Humanized Liver

    • Author(s)
      MIKIRO NAKASHIMA
    • Organizer
      第51回国際トキシコロジー学会
    • Place of Presentation
      サンフランシスコ(米国)
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] 同一有効成分の医薬品適用時における薬剤性肝障害のリスク予測法に関する研究

    • Author(s)
      中嶋幹郎
    • Organizer
      第5回日本ジェネリック医薬品学会学術大会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-23590187
  • [Presentation] ジェネリック医薬品の薬剤性肝障害リスク評価

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      日本病院薬剤師会東北ブロック第4回学術大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-05-31 – 2014-06-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460220
  • [Presentation] T-LEX法を用いたテープ剤の肝障害リスクに関する製剤同等性予測試験

    • Author(s)
      中嶋幹郎 ら
    • Organizer
      日本薬学会135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460220
  • 1.  NAKAMURA Junzo (30115901)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 2.  NISHIDA Koyo (20237704)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 5 results
  • 3.  SASAKI Hitoshi (00170689)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 11 results
  • 4.  大山 要 (50437860)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 5.  SAKAEDA Toshiyuki (00304098)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KAWAKAMI Shieru (20322307)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  FUMOTO Shintaro (70380988)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  相原 希美 (60908557)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SHIMADA Takashi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 10.  NAGATSUKA Shin-ichiro
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 11.  TACHIKI Hidehisa
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 12.  NAKASHIMA Mihoko (00301367)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 13.  MUKAI Takahiro (30284706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  新留 琢郎 (26204210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  宮元 敬天 (20619481)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  竹林 実 (60304440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  山口 拓 (80325563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  小川 さやか (80629171)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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