SAEGUSA Makoto 三枝信

Researcher Number	00265711
Affiliation (Current)	2025: 北里大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2010 – 2024: Kitasato University, 医学部, 教授 2008 – 2009: Kitasato University, 医学部, 准教授 2006: Kitasato University, Pathology, Associate Professor, 医学部, 助教授 2003 – 2005: 北里大学, 医学部, 講師 1995 – 2001: 北里大学, 医学部, 講師 1998: 北里大学, 医学部・病理学, 講師
Review Section/Research Field	Principal Investigator Human pathology / Human pathology / Basic Section 49020:Human pathology-related Except Principal Investigator Human pathology / Basic Section 49020:Human pathology-related / Human pathology
Keywords	Principal Investigator 子宮内膜癌 / p53 / TCF4 / 子宮癌肉腫 / beta-catenin / β-カテニン / p14 / p21WAF1 / アポトーシス / 上皮間葉転換 … More / S100A4 / 子宮内膜癌細胞 / p16 / p300 / endometrial cancer / p14ARF / Beta-catenin / βーカテニン / 癌幹細胞 / Sox4 / 細胞増殖 / endometrial carcinoma / CD44 / bcl-2 / 免疫染色 / ALK / 子宮がん肉腫 / がん幹細胞 / 非筋細胞ミオシンII / 増殖 / ｐ５３ / MDM2 / S100A1 / 間質 / 癌・間質インターラクション / Myosin / 子宮癌肉所 / NMIIA / MYH9 / ミオシン9 / pRb / p16^<INK4A> / p21 / senescence / EMT / Slug / Sox / Sox４ / NF-κB / Sox9 / Sox7 / TCF4遺伝子 / β-カテニン遺伝子 / Sox遺伝子 / 月経周期 / 正常子宮内膜 / bc1-2 / Par4 / Par-4 / Uterine cervical carcinoma / ovarian carcinoma / Endometrial carcinoma / 卵巣癌 / 子宮頚部癌 / hormone receptor / menstrual cycle / RT-PCR / endometrial corinoma / PR / ER / cell proliferation / apoptosis / 分子病理学 / 子宮頚癌 … More Except Principal Investigator アポトーシス / 細胞増殖 / 甲状腺癌 / 直腸癌 / 卵巣明細胞癌 / 甲状腺炎 / 癌幹細胞ニッチ / thyroiditis / 細胞極性 / MYH9 / プロテオミクス / EBP50 / 浸潤性小葉癌 / 簇出 / S100A4 / 進行大腸癌 / PD1 / PDL1 / 進行期直腸癌 / 癌免疫監視回避機構 / PD-L1 / NCRT / がん幹細胞 / βーカテニン / 化学・放射線療法 / β-カテニン / 上皮間葉転換 / 化学放射線療法 / 癌幹細胞 / エキソソーム / バイオマーカー / Smad2 / Lefty / 卵巣明細胞 / Lefty遺伝子 / TGF-beta / LEFTY / 病理診断支援システム / ディープラーニング（深層学習） / テキストマイニング / 病理組織標本 / 病理診断報告書 / 診断支援システム / 深層学習法 / 画像解析 / テキストマイニング解析 / 病理診断 / carcinogenesis / Ras gene / RET protoncogene / thyroid cancer / 発がん / Ras遺伝子 / RETがん遺伝子 / apoptosis / cell proliferation / differentiation / telemere length / telemerase / thyroid tumors / テロメレーズ / 細胞分化 / テロメア / テロメラーゼ / NF-κB / 腫瘍分化・増殖様式 / 卵巣子宮内膜症性嚢胞 / ｂｃｌ－２ / HNF-1β / bcl2 / NF-kB / HNF-1beta / olfactmedin 4 / 発癌 / 潰瘍性大腸炎 / olfactomedin-4 / OLFM4 / 炎症 / 発現 / 炎症性腸疾患 / 潰瘍性大腸 / 細胞回転 / p53蛋白 / リンパ球性甲状腺炎 / 自己免疫病 / 細胞死 / 発癌促進作用 Less

Interaction Between Lipid Metabolism Genes and Local Estrogen Synthesis in Invasive Lobular Carcinoma
- Principal Investigator
  
  柴原裕紀子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
ALK関連子宮内膜癌の同定、その生物学的特性の解明、そして新規治療戦略への展開Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma
- Principal Investigator
  
  松本俊英
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
進行期直腸癌のS100A4依存性癌幹細胞ニッチ形成を標的とした新規治療戦略
- Principal Investigator
  
  高橋博之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
Induction of stem cell features by S100A4/NMII signals in uterine carcinosarcomaPrincipal Investigator
- Principal Investigator
  
  Saegusa Makoto
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
Association of nuclear beta-catenin and PD1/PDL1 expression with cancer stem niche in advanced rectal cancer
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
S100A4/non-muscle Myosin II Signaling Regulates Epithelial-Mesenchymal Transition and Stemness in Uterine CarcinosarcomaPrincipal Investigator
- Principal Investigator
  
  Saegusa Makoto
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma
- Principal Investigator
  
  Kajita Sajiine
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Application of text mining techniques and image analysis in pathology diagnosis
- Principal Investigator
  
  Hara Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Possible role of nuclear b-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Molecular analysis of cancer stem cells drived from uterine carcinosarcomaPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Transcriptional upregulation of HNF-1beta by NF-kB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression
- Principal Investigator
  
  Kajita Sabine
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Molecular mechanism of OLFM4 and the significance as an inflammatory biomarker and therapeutic target for ulcerative colitis
- Principal Investigator
  
  YOSHIDA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Sox4 functions as a positive regulator of beta-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomasPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A functional role of Par-4 in endometrial tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A role of β-catenin signaling loop on cell proliferation and differentiation of endometrial carcinomas : Implication for gene therapyPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A role of beta-catenin/p53 pathway on tumor cell proliferation and differenatiation of endometrial carcinoma cellsPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
子宮内膜癌、頚癌及び卵巣癌におけるCD44遺伝子発現異常に関与する転写因子の解明Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Promotion effect of lymchocytic thyroiditis in thyroid carcinogenesis by activation of RET protoncogene
- Principal Investigator
  
  OKAYASU Isao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KITASATO UNIVERSITY
子宮内膜の癌化及び腫瘍進展過程におけるCD44蛋白発現の果たす役割の解明Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
The role of telomerase activity in thyroid tumorigenesis
- Principal Investigator
  
  OKAYASU Isao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KITASATO UNIVERSITY
リンパ球性甲状腺炎における甲状腺発癌促進作用の蛋白・遺伝子異常からの解明
- Principal Investigator
  
  岡安勲
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
子宮体癌の増殖制御機構とBcl-2,Box.蛋白及びホルモンレセプター発現の解析Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
慢性リンパ球性甲状腺炎における甲状腺発癌促進作用の証明
- Principal Investigator
  
  OKAYASU Isao
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
子宮頚癌の発生・進展過程におけるHPV感染とアポトーシスの分子病理学的研究Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University

[Journal Article] Immunoglobulin G4-related thyroiditis associated with Graves’ disease: A case report2024
- Author(s)
  Takahashi Hiroyuki、Kajita Sabine、Katoh Hiroshi、Matsumoto Toshihide、Inoue Akemi、Sangai Takafumi、Saegusa Makoto
- Journal Title
  
  Heliyon
  
  Volume: 10 Issue: 4 Pages: e25843-e25843
- DOI
  10.1016/j.heliyon.2024.e25843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06472, KAKENHI-PROJECT-20K07397
[Journal Article] Nucleobindin-2 mediates TGF-beta1-driven phenotypes in ZEB1-high uterine carcinosarcoma2023
- Author(s)
  Yui Kobayashi , Ako Yokoi , Miki Hashimura, Yasuko Oguri, Ryo Konno, Toshihide Matsumoto, Masataka Tochimoto, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Yohei Harada, Naomi Fukagawa, Yoshio Kodera, Makoto Saegusa
- Journal Title
  
  Am J Pathol
  
  Volume: 193 Issue: 8 Pages: 1116-1128
- DOI
  10.1016/j.ajpath.2023.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14485, KAKENHI-PROJECT-23K06472, KAKENHI-PROJECT-20K07397
[Journal Article] Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma2023
- Author(s)
  Nakagawa Mayu、Matsumoto Toshihide、Yokoi Ako、Hashimura Miki、Oguri Yasuko、Konno Ryo、Ishibashi Yu、Ito Takashi、Ohhigata Kensuke、Harada Yohei、Fukagawa Naomi、Kodera Yoshio、Saegusa Makoto
- Journal Title
  
  Molecular Oncology
  
  Volume: 17 Issue: 10 Pages: 2168-2182
- DOI
  10.1002/1878-0261.13503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06472, KAKENHI-PROJECT-20K07397
[Journal Article] Anaplastic lymphoma kinase overexpression enhances aggressive phenotypic characteristics of endometrial carcinoma2023
- Author(s)
  Yokoi A, Nakamura Y, Hashimura M, Oguri Y, Matsumoto T, Nakagawa M, Ishibashi Y, Ito T, Ohhigata K, Harada Y, Fukagawa N, Saegusa M.
- Journal Title
  
  BMC Cancer
  
  Volume: 23 Issue: 1 Pages: 765-765
- DOI
  10.1186/s12885-023-11144-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06471, KAKENHI-PROJECT-23K06472, KAKENHI-PROJECT-20K07397
[Journal Article] Functional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells2022
- Author(s)
  Nakagawa M, Higuchi S, Hashimura M, Oguri Y, Matsumoto T, Yokoi A, Ishibashi Y, Ito T, Saegusa M
- Journal Title
  
  BMC Cancer
  
  Volume: 22 Issue: 1 Pages: 184-184
- DOI
  10.1186/s12885-022-09249-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07413, KAKENHI-PROJECT-20K07397
[Journal Article] A combination of stromal <scp>PD‐L1</scp> and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal carcinoma2022
- Author(s)
  Takahashi Hiroyuki、Watanabe Hirono、Hashimura Miki、Matsumoto Toshihide、Yokoi Ako、Nakagawa Mayu、Ishibashi Yu、Ito Takashi、Ohhigata Kensuke、Saegusa Makoto
- Journal Title
  
  The Journal of Pathology: Clinical Research
  
  Volume: 8 Issue: 5 Pages: 458-469
- DOI
  10.1002/cjp2.285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07397, KAKENHI-PROJECT-19K07421
[Journal Article] Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype2020
- Author(s)
  Yokoi Ako、Matsumoto Toshihide、Oguri Yasuko、Hasegawa Yoshinori、Tochimoto Masataka、Nakagawa Mayu、Saegusa Makoto
- Journal Title
  
  Cell Communication and Signaling
  
  Volume: 18 Issue: 1 Pages: 103-103
- DOI
  10.1186/s12964-020-00580-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07397, KAKENHI-PROJECT-17K08703, KAKENHI-PROJECT-17K15654
[Journal Article] S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma2020
- Author(s)
  Hiruta Ai、Oguri Yasuko、Yokoi Ako、Matsumoto Toshihide、Oda Yusuke、Tomohiro Mikihisa、Hashimura Miki、Jiang Zesong、Tochimoto Masataka、Nakagawa Mayu、Saegusa Makoto
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 190 Issue: 11 Pages: 2304-2316
- DOI
  10.1016/j.ajpath.2020.07.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07397, KAKENHI-PROJECT-17K08703, KAKENHI-PROJECT-17K15654
[Journal Article] Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions.2019
- Author(s)
  Mirura R, Yokoi A, Matsumoto T, Oguri Y, Hashimura M, Tochimoto M, Kajita S, Saegusa M
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Issue: 1 Pages: 308-308
- DOI
  10.1186/s12885-019-5539-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15250
[Journal Article] Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma.2017
- Author(s)
  Akiya M, Yamazaki M, Matsumoto T, Kawashima Y, Oguri Y, Kajita S, Kijima D, Chiba R, Yokoi A, Takahashi H, Kodera Y, Saegusa M.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 38 Pages: 63646-63664
- DOI
  10.18632/oncotarget.18882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15250, KAKENHI-PROJECT-17K19926, KAKENHI-PROJECT-17H02206, KAKENHI-PROJECT-15K08385
[Journal Article] Possible role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer2017
- Author(s)
  Hiroyuki Takahashi, Kie Nakamura, Akane Usami, Tomoko Tsuruta, Miki Hashimura, Toshihide Matsumoto, Makoto Saegusa
- Journal Title
  
  Histopathology
  
  Volume: 印刷中 Issue: 2 Pages: 227-237
- DOI
  10.1111/his.13227
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08385
[Journal Article] Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma2016
- Author(s)
  Inoue H , Takahashi H, Hashimura M, Eshima K, Akiya M, Matsumoto T, Saegusa M
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Issue: 1 Pages: 53-53
- DOI
  10.1186/s12885-016-2090-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460427
[Journal Article] Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression.2015
- Author(s)
  Suzuki E, Kajita S, Takahashi H, Matsumoto T, Tsuruta T, Saegusa M.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 95 Issue: 8 Pages: 962-972
- DOI
  10.1038/labinvest.2015.73
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670179
[Journal Article] Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus.2014
- Author(s)
  Takahashi, H., Yoshida, T., Matsumoto, T., Kameda, Y., Takano, Y., Tazo, Y., Inoue, H, Saegusa, M.
- Journal Title
  
  Hum Pathol
  
  Volume: 45 Issue: 1 Pages: 33-40
- DOI
  10.1016/j.humpath.2013.06.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590452, KAKENHI-PROJECT-24790361
[Journal Article] Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor B/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas.2013
- Author(s)
  Yoshida T, Hashimura M, Kuwata T, Matsumoto T, Suzuki E, Tazo Y, Nakajima H, Inukai M, Saegusa M.
- Journal Title
  
  Human Pathology
  
  Volume: 44 Pages: 1780-1788
- Data Source
  KAKENHI-PROJECT-23590415
[Journal Article] Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells.2013
- Author(s)
  Yoshida, T., Hashimura, M., Matsumoto, T., Tazo, Y., Inoue, H., Kuwata, T., Saegusa, M.
- Journal Title
  
  Lab Invest
  
  Volume: 93 Issue: 11 Pages: 1184-1193
- DOI
  10.1038/labinvest.2013.111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590452
[Journal Article] Transcriptional regulation of the alpha-1 type II collagen gene by NF-κB/p65 and Sox9 in the chondrocystic phenotype of uterine carcinosarcomas2013
- Author(s)
  Yoshida T, Hashimura M, Kuwata T, Matsmoto T, Suzuki E, Tazo Y, Nakajima H, Inukai M, Saegusa M
- Journal Title
  
  Hum Pathol
  
  Volume: 44 Issue: 9 Pages: 1780-1788
- DOI
  10.1016/j.humpath.2012.12.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590415, KAKENHI-PROJECT-24590452
[Journal Article] Transcriptional up-regulation of Sox9 by NF-κB in endometrial carcinoma cells, modulating cell proliferation through alteration in the p14^<ARF>/p53/p21^<WAF1>pathway2012
- Author(s)
  Saegusa M, Hashimura M, Suzuki E, Yoshida T, Kuwata T
- Journal Title
  
  Am J Pathol
  
  Volume: 181 Issue: 2 Pages: 684-692
- DOI
  10.1016/j.ajpath.2012.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590415
[Journal Article] Sox4 functions as a positive regulator ofβ-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas2012
- Author(s)
  Saegusa M, Hashimura M, Kuwata T
- Journal Title
  
  Lab Invest
  
  Volume: 92 Issue: 4 Pages: 511-521
- DOI
  10.1038/labinvest.2011.196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590415
[Journal Article] Transcriptional regulation of pro-apoptotic Par-4 by NF-kB/p65 and its function in controlling cell kinetics during early events in endometrial tumorigenesis.2010
- Author(s)
  Saegusa M, Hashimura M, Kuwata T, Okayasu I.
- Journal Title
  
  J Pathol 221
  
  Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590352
[Journal Article] Transcriptional regulation of pro-apoptotis Par4 by NF-κB/p65 and its function in controlling cell kinetics during early events in endometrial tumorigenesis2010
- Author(s)
  Saegusa M, et al
- Journal Title
  
  Journal of Pathology
  
  Volume: 221 Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590352
[Journal Article] Induction of p16^<INK4A> mediated by p-catenin in a TCF4-independent manner: Implication for alteration in p16^<INK4A> and pRb expression2006
- Author(s)
  Saegusa M et al.
- Journal Title
  
  International Journal of Cancer 119
  
  Pages: 2294-2303
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Induction of p16INK4A mediated by β-catenin in a TCF4-independent manner : Implication for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells2006
- Author(s)
  Saegusa M et al.
- Journal Title
  
  International Journal of Cancer 119
  
  Pages: 2294-2303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Induction of p16 mediated by β-catenin in a TCF4-independent manner : Implication for alterations in p16 and pRb expression2006
- Author(s)
  Saegusa M et al.
- Journal Title
  
  International Journal of Cancer 119
  
  Pages: 2294-2303
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Upregulation of TCF4 expression as transcriptional target of β-catenin/p300 complexes2005
- Author(s)
  Saegusa M et al.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 768-779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Upregulation of TCF4 expression as a transcriptional target Ofβ-catenin/p300 complexes2005
- Author(s)
  Saegusa M et al.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 768-779
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Upregulation of TCF4 expression as a transcriptional target of β-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells2005
- Author(s)
  Saegusa M, et al.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 768-779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] β-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cylin D1 during squamous differentiation of endometrial carcinoma cells2004
- Author(s)
  Saegusa M et al.
- Journal Title
  
  Am J Pathol 164
  
  Pages: 1739-1749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590313
[Journal Article] β-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells2004
- Author(s)
  Saegusa M et al.
- Journal Title
  
  American Journal of Pathology 164
  
  Pages: 1739-1749
- Data Source
  KAKENHI-PROJECT-15590313
[Journal Article] β-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cylin D1 during squamous differentiation of endometrial carcinoma cells2004
- Author(s)
  Saegusa m et al.
- Journal Title
  
  American Journal of Pathology 164
  
  Pages: 1739-1749
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590313
[Presentation] 再発卵巣明細胞癌におけるEBP50/PARP1系は化学療法耐性能と予後に寄与する2023
- Author(s)
  松本俊英、横井愛香、紺野亮、小栗康子、橋村美紀、中川茉祐、小寺義男、三枝信
- Organizer
  日本プロテオーム学会2023年大会
- Data Source
  KAKENHI-PROJECT-23K06472
[Presentation] 卵巣漿液癌におけるALK発現は腫瘍高悪性度化と予後に寄与する2023
- Author(s)
  松本俊英、小田祐介、長谷川嘉則、橋村美紀、小栗康子、井上久子、横井愛香、三枝信
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06472
[Presentation] 子宮内膜ならびに子宮内膜癌におけるS100A1とMDM2の相互作用が p53機能に及ぼす影響の検討2023
- Author(s)
  栃本昌孝，中川茉祐，橋村美紀, 小栗康子，松本俊英，横井愛香，石橋侑，伊藤隆士，三枝信
- Organizer
  大12回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K07413
[Presentation] 進行大腸癌におけるS100A4発現の意義2023
- Author(s)
  原田　洋平、深川　菜央美、伊藤　隆、石橋　侑、橋村　美紀、小栗　康子、松本　俊英、高橋　博之、三枝　信
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K06967
[Presentation] 子宮癌肉腫のS100A4/非筋細胞ミオシンII系による肉腫成分誘導機構の解明2020
- Author(s)
  栃本　昌孝, 三枝信
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08703
[Presentation] 深層学習による病理自動診断　病理医不要の日は近い！？2017
- Author(s)
  原　敦子、石橋優一、三枝　信
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08386
[Presentation] 進行期直腸癌のb-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2017
- Author(s)
  高橋博之，橋村美紀，松本俊英，三枝信
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] The role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in rectal carcinoma2017
- Author(s)
  高橋博之、橋村美紀、松本俊英、三枝信
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 進行期直腸癌のβ-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2016
- Author(s)
  高橋博之、宇佐美茜、千葉理紗子、橋村美紀、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] Sox4/β-カテニン/p300/Slug系は上皮間葉転換/がん幹細胞化を介して子宮癌肉腫の肉腫成分形成に関与する2016
- Author(s)
  橋村美紀、高橋博之、井上久子、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460427
[Presentation] 電子化標本画像解析による客観的病理診断のモデル化2016
- Author(s)
  原　敦子、石橋雄一、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台（国際センター）
- Data Source
  KAKENHI-PROJECT-15K08386
[Presentation] 卵巣明細胞腺癌の発癌・進展過程におけるLeftyの機能解析2016
- Author(s)
  秋谷昌史、山崎真瑛、松本俊英、梶田咲美乃、三枝信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16K15250
[Presentation] 進行期直腸癌のb-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2015
- Author(s)
  高橋博之、中村貴恵、鶴田智子、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 炎症バイオマーカーolfactomedin 4の発現からみた炎症性腸疾患の病因病態.2015
- Author(s)
  横田　章、吉田　功、大熊拓也、橋口　収、三上哲夫、徳山　宣、岡安　勲、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 潰瘍性大腸炎におけるバイオマーカーolfactomedin 4の発現機序.2015
- Author(s)
  橋口　収、吉田　功、大熊拓也、横田　章、岡安　勲、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 潰瘍性大腸炎バイオマーカーolfactomedin 4の機能同定とその意義.2015
- Author(s)
  大熊拓也、吉田　功、橋口　収、横田　章、岡安　勲、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] NF-κB/Sox9によるCol2A1遺伝子発現制御を介した子宮内膜癌肉腫細胞の軟骨分化誘導機構2013
- Author(s)
  橋村美紀, 三枝信, 他
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] Sox4はβ-カテニン/TCF4シグナル伝達系と協調して子宮内膜癌細胞の増殖制御・転位分化を促進する2012
- Author(s)
  三枝　信、橋村美紀、桑田健
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] Sox4は, β-カテニン/TCF4シグナル伝達系と協調して子宮内膜癌細胞の増殖制御・転位分化を促進する2012
- Author(s)
  三枝信, 他
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] アポトーシス関連遺伝子Par-4による子宮内膜細胞動態調節機構と発癌2010
- Author(s)
  三枝信, 他
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-20590352
[Presentation] アポトーシス関連遺伝子Par-4 による子宮内膜細胞動態調節機構と発癌2010
- Author(s)
  三枝信、橋村美紀、桑田健、岡安勲
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590352
[Presentation] 潰瘍性大腸炎腫瘍発生における炎症性バイオマーカーOLFM4の役割
- Author(s)
  吉田功、山本渚、横田章、大熊拓也、岡安勲、三枝信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 炎症性腸疾患バイオマーカーOLFM4発現調節と潰瘍性大腸炎・クローン病の疾患特異性.
- Author(s)
  横田章、吉田功、山本渚、岡安勲、三枝信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 卵巣明細胞腺癌におけるHNF-1β/NF-κB系の機能解析
- Author(s)
  鈴木エリ奈、梶田咲美乃、三枝　信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場他（広島県広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25670179
[Presentation] NF-kB/Sox9によるCol2A1遺伝子発現制御を介した子宮癌肉腫細胞の軟骨分化誘導機構
- Author(s)
  橋村美紀、田雑有紀、中島裕康、原　敦子、吉田　功、三枝　信
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] Sox9によるp14ARF/p53/p21waf1系を介した子宮内膜癌細胞の増殖制御機構
- Author(s)
  三枝　信、犬飼　円、鈴木エリ奈、山本　渚、西　達也、松本俊英、桑田　健
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] 潰瘍性大腸炎におけるOLFM4発現誘導機序の解明とその意義.
- Author(s)
  山本渚、吉田功、横田章、岡安勲、三枝信
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 卵巣明細胞癌におけるHNF-β発現の機能解析とその臨床的意義について
- Author(s)
  鈴木エリ奈、梶田咲美乃、鶴田智子、三枝信
- Organizer
  第102回　日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25670179

1. OKAYASU Isao (20014342)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. Takahashi Hiroyuki (60377330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. Kajita Sabine (60194734)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. MIKAMI Tetuo (90286352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Tsutomu (90316943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. Hara Atsuko (10276123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 柴原裕紀子 (30645932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 三階貴史 (00375685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松本俊英 (10623184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. Ishibashi Yuichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Hashimura Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. Nakamura Kie

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. Usami Akane

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 栃本昌孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAEGUSA Makoto 三枝 信

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ALK関連子宮内膜癌の同定、その生物学的特性の解明、そして新規治療戦略への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of stem cell features by S100A4/NMII signals in uterine carcinosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

S100A4/non-muscle Myosin II Signaling Regulates Epithelial-Mesenchymal Transition and Stemness in Uterine CarcinosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of cancer stem cells drived from uterine carcinosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sox4 functions as a positive regulator of beta-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A functional role of Par-4 in endometrial tumorigenesisPrincipal Investigator

SAEGUSA Makoto 三枝信