Nakagawa Toshiyuki 中川敏幸

… Alternative Names

NAKAGAWA Toshiyuki 中川敏幸

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Researcher Number	00271502
Other IDs
Affiliation (Current)	2025: 岐阜大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2016 – 2023: 岐阜大学, 大学院医学系研究科, 教授 2011 – 2015: 岐阜大学, 医学(系)研究科(研究院), 教授 2010: Gifu University, 医学系研究科, 教授 2010: 岐阜大学, 医科系研究科, 教授 2007 – 2009: Gifu University, 大学院・医学系研究科, 教授 … More 2006: 岐阜大学, 大学院医学系研究科, 教授 2005: 岐阜大学, 大学院・医学系研究科, 教授 2002 – 2004: 岐阜大学, 大学院・医学研究科, 教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 59040:Nutrition science and health science-related / Integrated Nutrition Science / Eating habits / 細胞死(アポトーシス) / Eating habits, studies on eating habits / Neurochemistry/Neuropharmacology / Pathological medical chemistry Except Principal Investigator Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 小胞体ストレス / アルツハイマー病 / ATF4 / プレセニリン / アポトーシス / GCN2 / 統合的ストレス応答 / ガンマ-セクレターゼ / 海馬神経新生 / 長期肥満 … More / マイクロRNA / ダブルコルチン / 機能性食品 / 機能性食品成分 / 認知症 / アミロイド-β / GADD34 / アミノ酸センサー / レスベラトロール / 加齢 / オートファジー / ガンマーセクレターゼ / カスペース / 転写因子 / ミトコンドリア / Bcl-xL / エクソソーム / 海馬神経幹細胞 / 老化 / 栄養学 / 食品 / うつ / 記憶想起 / 翻訳開始因子 / eIF2 / 行動・心理症状 / ポリフェノール / regeneration / substrate / cell death / apoptosis / neural development / neuron / caspase / 再生 / 基質 / 細胞死 / 神経分化 / 神経細胞 / カスパーゼ / 食生活 / アルツハイマーモデルマウス / 介入試験 / 食品成分 / 記憶再生 / ケルセチン / 想起 / 記憶 / フラボノイド / 糖尿病 / 肥満 / メタボリック症候群 / アミロイドｰβ / PERK / eIF2α / アミロイドーベータ / eIF2alpha / ガンマセクレターゼ / ブレセニリン / ロイシン / food intake experiment / アミノ酸 / siRNA / atg5 / 癌 / 神経変性疾患 / スクリーニング / ゲノム / アミノ酸飢餓 / Apaf-1 / Bak / Bax / 蛋白質品質管理 / ERAD / 細胞内小器官 … More Except Principal Investigator PC-12細胞 / Na^+ポンプ / 再生 / 脊髄損傷 / 局所麻酔薬 / PLD / ATPsensitive K+チャネル / PC12 cell / 細胞内シグナル伝達 / 虚血後血管反応 / テトラカイン / adnylate cyclase / milrinone / ERK / MAPK / 脊髄虚血 Less

Analysis of the molecular mechanism of the onset of Dementia due to chronic obesityPrincipal Investigator
- Principal Investigator
  
  中川敏幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gifu University
Therapeutic targeting the endoplasmic reticulum stressto delay onset of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Nakagawa Toshiyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gifu University
Analysis of functional food to prevent wandering caused by impairment of memory recalllPrincipal Investigator
- Principal Investigator
  
  Nakagawa Toshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Gifu University
Analysis of prevention of Alzheimer's disease based on underlying pathologyPrincipal Investigator
- Principal Investigator
  
  Nakagawa Toshiyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Gifu University
Analysis of underlying mechanism to develop Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  NAKAGAWA Toshiyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Gifu University
Analysis of amino acid imbalance underlying Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  NAKAGAWA Toshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Gifu University
転写因子ATF4によるガンマ-セクレターゼ活性化の制御機構の解明Principal Investigator
- Principal Investigator
  
  中川敏幸
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gifu University
機能的スクリーニング法の確立による小胞体ストレス制御因子の網羅的探索・機能解析Principal Investigator
- Principal Investigator
  
  中川敏幸
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
小胞体ストレスによるカスパーゼ活性化におけるBc1-xL依存性制御機構の解明Principal Investigator
- Principal Investigator
  
  中川敏幸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
小胞体ストレスによるプレセニリン蛋白質の成熟制御機構の解明Principal Investigator
- Principal Investigator
  
  中川敏幸
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
脊髄損傷後の脊髄再生プロセスにおけるNa^+-K^+ATPaseの役割
- Principal Investigator
  
  土肥修司
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Gifu University
Bcl-xLによる小胞体ストレス誘導性アポトーシスの制御機構の解明Principal Investigator
- Principal Investigator
  
  中川敏幸
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Analyses of molecular mechanisms of caspases during neural developmentPrincipal Investigator
- Principal Investigator
  
  NAKAGAWA Toshiyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Gifu University

[Journal Article] GADD34 suppresses eIF2α phosphorylation and improves cognitive function in Alzheimer's disease-model mice2023
- Author(s)
  Miki Hayakawa-Ogura, Tana, Toshiyuki Nakagawa, Masanori Itoh
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 654 Pages: 112-119
- DOI
  10.1016/j.bbrc.2023.02.077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11622
[Journal Article] Continuous intake of quercetin-rich onion powder may improve emotion but not regional cerebral blood flow in subjects with cognitive impairment2023
- Author(s)
  Hayashi Yuichi、Hyodo Fuminori、Tana、Nakagawa Kiyomi、Ishihara Takuma、Matsuo Masayuki、Shimohata Takayoshi、Nishihira Jun、Kobori Masuko、Nakagawa Toshiyuki
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 8 Pages: e18401-e18401
- DOI
  10.1016/j.heliyon.2023.e18401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10319, KAKENHI-PROJECT-23K10823
[Journal Article] Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity2022
- Author(s)
  Kiyomi Nakagawa, Saiful Islam, Masashi Ueda, Toshiyuki Nakagawa
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1022-1022
- DOI
  10.1038/s41598-022-05012-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11622
[Journal Article] Luteolin ameliorates depression-like behaviors by suppressing ER stress in a mouse model of Alzheimer's disease2022
- Author(s)
  Tana, Toshiyuki Nakagawa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 588 Pages: 168-174
- DOI
  10.1016/j.bbrc.2021.12.074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11622
[Journal Article] Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity2019
- Author(s)
  Eri Ohta, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Miki Hayakawa-Ogura, Shimo Li, Emika Nishida, Kazunori Ohta, Tana, Saiful Islam, Kiyomi Nakagawa, Tomomi Sunayama, Huayue Chen, So Hirata, Masashi Endo,Yoya Ohno, Toshiyuki Nakagawa.
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 7 Pages: e0219782-e0219782
- DOI
  10.1371/journal.pone.0219782
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00915
[Journal Article] Quercetin regulates the integrated stress response to improve memory2019
- Author(s)
  Nakagawa T, Ohta K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20 Issue: 11 Pages: 2761-2761
- DOI
  10.3390/ijms20112761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00915
[Journal Article] Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice2018
- Author(s)
  Kobori M, Takahashi Y, Takeda H, Takahashi M, Izumi Y, Akimoto Y, Sakurai M, Oike H, Nakagawa T, Itoh M, Bamba T, Kimura T.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 9081-9081
- DOI
  10.1038/s41598-018-27105-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00915, KAKENHI-PROJECT-18H01800
[Journal Article] Odor preference and olfactory memory are impaired in Olfaxin-deficient2018
- Author(s)
  Islam S, Ueda M, Nishida E, Wang MX, Osawa M, Lee D, Itoh M, Nakagawa K, Tana, Nakagawa T.
- Journal Title
  
  Brain Research
  
  Volume: 1688 Pages: 81-90
- DOI
  10.1016/j.brainres.2018.03.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00915
[Journal Article] A randomized, double-blind, placebo-controlled study evaluating the effects of quercetin-rich onions on cognitive function in elderly subjects.2017
- Author(s)
  Nishimura M, Ohkawara T, Nakagawa T, Muro T, Sato Y, Satoh H, Kobori M, Nishihira J
- Journal Title
  
  Functional Foods in Health and Disease
  
  Volume: 7 Pages: 353-374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00915
[Journal Article] Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression.2017
- Author(s)
  Nakagawa K, Ueda M, Itoh M, Islam S, Tana, Nakagawa T
- Journal Title
  
  J Neurol Neurosci
  
  Volume: 8 Issue: 06 Pages: 234-234
- DOI
  10.21767/2171-6625.1000234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00915
[Journal Article] Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients.2016
- Author(s)
  Nakagawa T, Itoh M, Ohta K, Hayashi Y, Hayakawa M, Yamada Y, Akanabe H, Chikaishi T, Nakagawa K, Itoh Y, Muro T, Yanagida D, Nakabayashi R, Mori T, Saito K, Ohzawa K, Suzuki C, Li S, Ueda M, Wang MX, Nishida E, Islam S, Tana, Kobori M, Inuzuka T.
- Journal Title
  
  NeuroReport
  
  Volume: 27 Issue: 9 Pages: 671-676
- DOI
  10.1097/wnr.0000000000000594
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26500006, KAKENHI-PROJECT-26460861
[Journal Article] Quercetin reduces eIF2α phosphorylation by GADD34 induction.2015
- Author(s)
  Hayakawa M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohzawa K, Kobori M, Inuzuka T, Nakagawa T.
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 36 Issue: 9 Pages: 2509-2518
- DOI
  10.1016/j.neurobiolaging.2015.05.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26500006
[Journal Article] Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax2014
- Author(s)
  M asashi Ueda, Shimo Li, Masanori Itoh, Yoshika Hayakawa-Yano, Miao-xing Wang, Miki Hayakawa, Ryoko Hasebe-Matsubara, Kazunori Ohta, Eri Ohta, Akihito Mizuno, Yoko Hida, Munekazu Matsumoto, Huayue Chen, Toshiyuki Nakagawa
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 443 Pages: 1232-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.2014
- Author(s)
  Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK.
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 未定 Issue: 13 Pages: 2561-2576
- DOI
  10.1007/s00018-013-1515-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-26500006
[Journal Article] Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.2014
- Author(s)
  Masashi Ueda, Shimo Li, Masanori Itoh, Yoshika Hayakawa-Yano, Miao-xing Wang, Miki Hayakawa, Ryoko Hasebe-Matsubara, Kazunori Ohta, Eri Ohta, Akihito Mizuno, Yoko Hida, Munekazu Matsumoto, Huayue Chen, Toshiyuki Nakagawa.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 443 Pages: 1232-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] Molecular cloning and sequence analysis of an extracellular protease from four bacillus strains.2013
- Author(s)
  Xujun Han, Yuh Shiwa, Masanori Itoh, Tohru Suzuki, Hirofumi Yoshikawa, Toshiyuki Nakagawa, Hiroko Nagano.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 77 Pages: 870-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] Molecular cloning and sequence analysis of an extracellular protease from four bacillus strains2013
- Author(s)
  Xujun Han, Yuh Shiwa, Masanori Itoh, Tohru Suzuki, Hirofumi Yoshikawa, Toshiyuki Nakagawa, Hiroko Nagano
- Journal Title
  
  Biosci. Biotechnol. Biochem
  
  Volume: 77 Pages: 870-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.2012
- Author(s)
  Shimo Li,YoshikaHayakawa-Yano,MasanoriItoh,MasashiUeda, Kazunori Ohta,YoshihiroSuzuki,AkihitoMizuno,EriOhta,YokoHida, Miao-xing Wang,ToshiyukiNakagawa
- Journal Title
  
  brain research
  
  Volume: 1488 Pages: 1-13
- DOI
  10.1016/j.brainres.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] Cayman Ataxia-Related Protein is a Presynapse-Specific Caspase-3 Substrate.2011
- Author(s)
  Itoh M, Li S, Ohta K, Yamada A, Hayakawa-Yano Y, Ueda M, Hida Y, Suzuki Y, Ohta E, Mizuno A, Banno Y, Nakagawa T.
- Journal Title
  
  Neurochemical Research. DOI 10.1007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300245
[Journal Article] Endoplasmic reticulum stress enhancesγ-secretase activity2011
- Author(s)
  Ohta K, Mizuno A, Li S, Itoh M, Ueda M, Ohta E, Hida Y, Wang MX, Furoi M, Tsuzuki Y, Sobajima M, Bohmoto Y, Fukushima T, Kobori M, Inuzuka T, Nakagawa T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 416 Pages: 362-366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] 認知症2011
- Author(s)
  太田和徳,中川敏幸
- Journal Title
  
  Functional Food
  
  Volume: 5 Pages: 47-51
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] ケルセチンとアルツハイマー病2011
- Author(s)
  太田和徳,中川敏幸
- Journal Title
  
  Functional Food
  
  Volume: 5 Pages: 135-138
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] Endoplasmic reticulum stress enhances γ-secretase activity.2011
- Author(s)
  Ohta K, Mizuno A, Li S, Itoh M, Ueda M, Ohta E, Hida Y, Wang MX, Furoi M, Tsuzuki Y, Sobajima M, Bohmoto Y, Fukushima T, Kobori M, Inuzuka T, Nakagawa T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 416 Issue: 3-4 Pages: 362-366
- DOI
  10.1016/j.bbrc.2011.11.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617007
[Journal Article] Autophagy impairment stimulates PS1 expression and β-secretase activity.2010
- Author(s)
  Ohta K, Mizuno A, Ueda M, Li S, Suzuki Y, Hida Y, Hayakawa-Yano Y, Itoh M, Ohta E, Kobori M, Nakagawa T.
- Journal Title
  
  Autophagy. 6
  
  Pages: 345-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300245
[Journal Article] An alternative spliced mouse presenilin-2 Mrna encodes a novel ・-secretase inhibitor.2009
- Author(s)
  Suzuki Y, Ohta K, Itoh M, Sakoh-Sumitomo Y, Mitsuda T, Ueda M, Hayakawa-Yano Y, Li S, Hida Y, Inuzuka T, Jung YK, Nakagawa T.
- Journal Title
  
  FEBS letters. 583
  
  Pages: 1403-1408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300245
[Journal Article] E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Aβ neurotoxicity.2008
- Author(s)
  Song S, Lee H, Kam TI, Tai ML, Lee JY, Noh JY, Shim SM, Seo SJ, Kong YY, Nakagawa T, Chung CW, Choi DY, Oubrahim H, Jung YK.
- Journal Title
  
  J Cell Biol. 182
  
  Pages: 675-684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300245
[Journal Article] ATF4 regulates γ-secretase activity during amino acid imbalance2007
- Author(s)
  Teruhiko Mitsuda, Yoshika Hayakawa, Masanori Itoh, Kazunori Ohta, Toshiyuki Nakagawa
- Journal Title
  
  Biochemical and Biophysical Research Communications 352
  
  Pages: 722-727
- Data Source
  KAKENHI-PROJECT-17028020
[Journal Article] Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells.2007
- Author(s)
  Y.Takai, T.Matikainen, A.Jurisicova, M.R.Kim, A.M.Trbovich, E.Fujita, T.Nakagawa, B.Lemmers, R.A.Flavell, R.Hakem, T.Momoi, J.Yuan, J.L.Tilly, G.I.Perez.
- Journal Title
  
  Apoptosis 12
  
  Pages: 791-800
- Data Source
  KAKENHI-PROJECT-17028020
[Journal Article] Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental-andspatial-dependent manner2007
- Author(s)
  Yoshika Hayakawa, Masanori Itoh, Aiko Yamada, Teruhiko Mitsuda, Toshiyuki Nakagawa
- Journal Title
  
  Brain Research 1129
  
  Pages: 100-109
- Data Source
  KAKENHI-PROJECT-17028020
[Journal Article] EGF-signaling Mediated by Gab1 Is Required for the Spatiotemporally Regulated Proliferation of Olig2-expressing Progenitors in the Embryonic Spinal Cord.2007
- Author(s)
  Y.Hayakawa-Yano, K.Nishida, S.Fukami, Y.Gotoh, T.Hirano, T.Nakagawa, T.Shimazaki, H.Okano.
- Journal Title
  
  Stem cells 25(in press)
- Data Source
  KAKENHI-PROJECT-17028020
[Journal Article] 細胞内小器官特異的caspase活性化機構と細胞死シグナル2004
- Author(s)
  光田輝彦, 中川敏幸
- Journal Title
  
  実験医学 22
  
  Pages: 107-111
- Data Source
  KAKENHI-PROJECT-16659083
[Journal Article] 細胞内小器官特異的caspase活性化機構と細胞死シグナル2004
- Author(s)
  光田輝彦, 中川敏幸
- Journal Title
  
  実験医学 22
  
  Pages: 107-111
- Data Source
  KAKENHI-PROJECT-15032218
[Presentation] Endoplasmic reticulum stress decreases 　　　the expression of doublecortin in the immature neurons of mice with long-term obesity2022
- Author(s)
  K. Nakagawa, S. Islam, M. Ueda, T. Nakagawa
- Organizer
  Society for Neuroscience meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11622
[Presentation] アルツハイマー病発症予防を目指した玉葱由来ケルセチンの作用機構の解明2019
- Author(s)
  太田和徳、中川敏幸
- Organizer
  岐阜薬科大学機能性健康食品研究講演会
- Data Source
  KAKENHI-PROJECT-17K00915
[Presentation] Activated integrated stress response in obese diabetic mice may cause impairment of adult hippocampal neurogenesis and episodic-like memory2019
- Author(s)
  Nakagawa K, Islam S, Ueda M, Nakagawa T
- Organizer
  ANNUAL MEETING Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00915
[Presentation] Olfactory function is impaired in Olfaxin deficient mice2018
- Author(s)
  Islam S, Ueda M, Nishida E, Wang MX, Itoh M, Nakagawa K, Tana, Nakagawa T.
- Organizer
  Society for neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00915
[Presentation] IMPROVEMENT OF MEMORY IMPAIRMENT BY DIETARY QUERCETIN SUPPLEMENTATION THROUGH SUPPRESSING ATF4 EXPRESSION IN A MURINE MODEL OF EARLY-STAGE ALZHEIMER’S DISEASE WITH OBESITY AND DIABETES2017
- Author(s)
  Nakagawa K, Ueda M, Itoh M, Hayakawa-Ogura M, Tana, Islam S, Nakagawa T
- Organizer
  第23回世界神経学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00915
[Presentation] アルツハイマー病予防に関する機能性食品成分の探索2017
- Author(s)
  他那、伊藤　正徳、中川　潔美、イスラム　サイフル、上田　昌史、王　淼星、中川　敏幸
- Organizer
  第12回小胞ストレス研究会
- Data Source
  KAKENHI-PROJECT-17K00915
[Presentation] 記憶の再生と小胞体ストレスシグナル2016
- Author(s)
  中川敏幸
- Organizer
  第11回小胞体ストレス研究会
- Place of Presentation
  岐阜大学サテライトキャンパス(岐阜市)
- Year and Date
  2016-10-10
- Data Source
  KAKENHI-PROJECT-26500006
[Presentation] Motor neurons were degenerated in the Prune homolog 2 (Drosophila) (Prune2) gene deficient mice generated by CRISPR/Cas9 system.2015
- Author(s)
  Masanori Itoh, Emika Nishida, Saiful Islam, Shimo Li, Masatake Osawa, Dongsoo Lee, Huayue Chen , Masashi Ueda, Miao-xing Wang, Miki Hayakawa, Gen Ikeno, Koki Ichihashi, Kazuyuki Okamoto, Jun Tsutsumi, Toshiyuki Nakagawa
- Organizer
  45th ANNUAL MEETING Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26500006
[Presentation] CUL4B PROMOTES APAF-1 POLYYUBIQUITINATION FOR CASPASE-9 ACTIVATION2013
- Author(s)
  Masanori Itoh, Eri Ohta, Yoko Hida, Miao-xing Wang, Masashi Ueda, Kazunori Ohta, Shimo Li, Akihito Mizuno, Tomomi Sunayama, Toshiyuki Nakagawa
- Organizer
  Cold Spring Harbor Asia
- Place of Presentation
  Suzhou(宿州)China
- Year and Date
  2013-04-16
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] Activation of gamma-secretase by endoplasmic reticurum stress2012
- Author(s)
  Kazunori Ohta, Akihito Mizuno, Shimo Li, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Wan-yu Lo, Toshiyuki Nakagawa
- Organizer
  42nd ANNUAL MEETING Neuroscience
- Place of Presentation
  New Orleans, USA
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] The expression and localization of Prune2 and its novel isoform in the central neuvous system2011
- Author(s)
  S.LI, M.ITOH, K.OHTA, M.UEDA, A.MIZUNO, E.OHTA, Y.HIDA, M.WANG, K.YAKEUCHI, T.NAKAGAWA
- Organizer
  41th ANNUAL MEETING Neuroscience2011
- Place of Presentation
  Washington DC, USA
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] The expression and localization of Prune2 and its novel isoform in the central neuvous system2011
- Author(s)
  S.LI, M.ITOH, K.OHTA, M.UEDA, A.MIZUNO, E.OHTA, Y.HIDA, M.WANG, K.YAKEUCHI, T.NAKAGAWA
- Organizer
  41thANNUAL MEETING Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] Endoplasmic reticulum stress leads to increase gamma-secretase activity and beta-amyloid production2011
- Author(s)
  K. Ohta, A. Mizuno, S. Li, M. Ueda, M. Itoh, E. Ohta, Y. Hida, M. Wang , M. Furoi, Y. Tuzuki, M. Sobajima, Y. Bohmoto, T. Fukushima, T. Nakagawa
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] Endoplasmic reticulum stress leads to increase gamma-secretase activity and beta-amyloid production2011
- Author(s)
  Kazunori Ohta, Akihito Mizuno, Shimo Li, Masashi Ueda, Masanori Itoh, Eri Ohta, Yoko Hida, Miao-xing Wang , Manabu Furoi, Yukihiro Tuzuki, Mituaki Sobajima, Yoshimasa Bohmoto, Tatsuya Fukushima, Toshituki Nakagawa
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜(3P-701)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] A novel regulation mechanism of synaptic transmission by preseynapse-localizing Caymanataxia-related protein,Caytaxin2011
- Author(s)
  M. itoh, S. Li, K. Ohta, M. Ueda, Y. Hida, Y. Suzuki, E. Ohta, A. Mizuno, M. Wang, T. Nakagawa
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] A novel regulation mechanism of synaptic transmission by preseynapse-localizing Caymanataxia-related protein,Caytaxin2011
- Author(s)
  Masanori itoh, Shimo Li, Kazunori Ohta, Masashi Ueda, Yoko Hida, Yoshihiro Suzuki, Eri Ohta, Akihito Mizuno, Miao-xing Wang, Toshiyuki Nakagawa
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜(1P-0921)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] Autophagy impairment leads to activation of gamma-secretase through GCN2.2010
- Author(s)
  中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  サンディエゴ,アメリカ
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] Autophagy impairment leads to activation of gamma secretase through GCN22010
- Author(s)
  太田和徳, 水野彰人, 上田昌史, 李詩沫, 鈴木欣宏, 樋田陽子, 早川-矢野佳芳, 伊藤正徳, 太田瑛里, 中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  Diego, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] オートファジーの機能低下がもたらすGCN2 を介したガンマセクレターゼ活性亢進機構の解明2010
- Author(s)
  太田和徳, 水野彰人, 上田昌史, 李詩沫, 鈴木欣宏, 樋田陽子, 早川-矢野佳芳, 伊藤正徳, 太田瑛里, 小堀真珠子, 中川敏幸
- Organizer
  Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] Disruption of the endoplasmic reticulum by polyglutamine expansion induces Apaf-1-dependent, activation of caspase-7.2009
- Author(s)
  中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  シカゴ,アメリカ
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-19650092
[Presentation] Disruption of the endoplasmic reticulum by polyglutamine expansion induces Apaf-1-dependent, activation of caspase-7.2009
- Author(s)
  中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  シカゴ,アメリカ
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] Disruption of the endoplasmic reticulum leads to Baxand Apaf-1-dependent activation of caspase-7.2009
- Author(s)
  上田昌史, 李詩沫, 早川-矢野佳芳, 太田和徳, 伊藤正徳, 樋田陽子, 太田瑛里, 水野彰人, 中川敏幸
- Organizer
  CELL DEATH Cold Spring Harbor Laboratory Meeting
- Place of Presentation
  New York, USA
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] Disruption of the endoplasmic reticulum by polyglutamine expansion induces Apaf-1-dependent, activation of caspase-7.2009
- Author(s)
  上田昌史, 李詩沫, 伊藤正徳, 樋田陽子, 早川-矢野佳芳, 鈴木欣宏, 太田和徳, 太田瑛里, 水野彰人, 中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] 前シナプスに局在するCayman 運動失調症原因タンパク質(Caytaxin)の機能発現におけるCaspase-3の役割2008
- Author(s)
  伊藤正徳, 李詩沫, 上田昌史, 太田和徳, 鈴木欣宏, 樋田陽子, 中川敏幸
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] The novel splicing isoforni of mouse presenilin-2 inlerrupts γ-secrctase complex, inhibiting its activity2008
- Author(s)
  中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  ワシントンDC, アメリカ
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] プレセニリン発現制御におけるオートファジーの役割の解明2008
- Author(s)
  太田和徳, 鈴木欣宏, 伊藤正徳, 李詩沫, 上田昌史, 樋田陽子, 中川敏幸
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] The novel splicing isoform of mouse presenilin-2 interrupts γ-secretase complex, inhibiting its activity.2008
- Author(s)
  Suzuki Y, Ohta K, Itoh M, Ueda M, Li S, Hida Y, Sakoh-Sumitomo Y, Mitsuda T, Hayakawa-Yano Y, Inuzuka T, Nakagawa T
- Organizer
  米国神経科学学会
- Place of Presentation
  Washington DC, USA
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] ガンマ‐セクレターゼ活性を制御する新規プレセニリン2 アイソフォームの解析2008
- Author(s)
  鈴木欣宏, 太田和徳, 伊藤正徳, 上田昌史, 李詩沫, 樋田陽子, 酒向ゆかり, 光田輝彦, 犬塚貴, 中川敏幸
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20300245
[Presentation] The novel splicing isoform of mouse presenilin-2 interrupts γ-secretase complex, inhibiting its activity2008
- Author(s)
  中川敏幸
- Organizer
  米国神経科学学会
- Place of Presentation
  ワシントンDC, アメリカ
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19650092
[Presentation] Activation of gamma-secretase by endoplasmic reticurum stress.
- Author(s)
  Kazunori Ohta, Akihito Mizuno, Shimo Li, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Wan-yu Lo, Toshiyuki Nakagawa.
- Organizer
  42nd ANNUAL MEETING Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] Polyglutamine expansion affects morphology of the endoplasmic reticulum-mitochondria contact site, initiating cell death.
- Author(s)
  Masashi Ueda, Shimo Li, Masanori Itoh, Kazunori Ohta, Miao-xing Wang, Huayue Chen, K.Yamaguchi, K. Kuwata, Miki Hayakawa, Yoko Hida, Toshiyuki Nakagawa.
- Organizer
  43rd ANNUAL MEETING Neuroscience.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23617007
[Presentation] 小胞体ストレス制御による記憶・認知機能改善作用
- Author(s)
  中川敏幸
- Organizer
  第12回日本機能性食品医用学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2014-12-13 – 2014-12-14
- Invited
- Data Source
  KAKENHI-PROJECT-26500006
[Presentation] 肥満・糖尿病によるアルツハイマー病モデルマウスの病態解明
- Author(s)
  早川実希、伊藤正徳、太田和徳、李　詩沫、上田昌史、王　淼星、西田江美香、中川敏幸
- Organizer
  第12回日本機能性食品医用学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2014-12-13 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-26500006
[Presentation] CUL4B PROMOTES APAF-1 POLYYUBIQUITINATION FOR CASPASE-9 ACTIVATION.
- Author(s)
  Masanori Itoh, Eri Ohta, Yoko Hida, Miao-xing Wang, Masashi Ueda, Kazunori Ohta, Shimo Li, Akihito Mizuno, Tomomi Sunayama, Toshiyuki Nakagawa.
- Organizer
  Cold Spring Harbor Asia.
- Place of Presentation
  Suzhou（宿州）　China
- Data Source
  KAKENHI-PROJECT-23617007

1. 土肥修司 (40155627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 早川佳芳 (60397320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HAYASHI Yuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 西村正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakagawa Toshiyuki 中川 敏幸

NAKAGAWA Toshiyuki 中川 敏幸

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Co-Researchers

Analysis of the molecular mechanism of the onset of Dementia due to chronic obesityPrincipal Investigator

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Therapeutic targeting the endoplasmic reticulum stressto delay onset of Alzheimer's diseasePrincipal Investigator

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Analysis of functional food to prevent wandering caused by impairment of memory recalllPrincipal Investigator

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Analysis of prevention of Alzheimer's disease based on underlying pathologyPrincipal Investigator

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Analysis of underlying mechanism to develop Alzheimer's diseasePrincipal Investigator

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Analysis of amino acid imbalance underlying Alzheimer's diseasePrincipal Investigator

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転写因子ATF4によるガンマ-セクレターゼ活性化の制御機構の解明Principal Investigator

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機能的スクリーニング法の確立による小胞体ストレス制御因子の網羅的探索・機能解析Principal Investigator

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小胞体ストレスによるカスパーゼ活性化におけるBc1-xL依存性制御機構の解明Principal Investigator

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小胞体ストレスによるプレセニリン蛋白質の成熟制御機構の解明Principal Investigator

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脊髄損傷後の脊髄再生プロセスにおけるNa^+-K^+ATPaseの役割

Principal Investigator

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Bcl-xLによる小胞体ストレス誘導性アポトーシスの制御機構の解明Principal Investigator

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Analyses of molecular mechanisms of caspases during neural developmentPrincipal Investigator

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Nakagawa Toshiyuki 中川敏幸

NAKAGAWA Toshiyuki 中川敏幸