AKAGI Masao 赤木將男

Researcher Number	00273441
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2022: 近畿大学, 医学部, 教授 2007: Kinki University, School of Med., Associate Professor 2004 – 2006: Kinki University, School of Med., Associate Professor, 医学部, 助教授 2002 – 2003: 近畿大学, 医学部, 講師 1996 – 1997: Kyoto University, Instructor Faculty of Medicine, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator 変形性膝関節症 / つくば高血圧マウス / 生活習慣病 / 軟骨変性 / 機械的ストレス / レニン・アンジオテンシン系 / 骨細胞アポトーシス / 膝OAモデルマウス / アポトーシス / DMM手術 … More / 破骨細胞 / 骨細胞 / 骨粗鬆化 / 閉経後骨粗鬆症 / 局所レニン・アンギオテンシン系 / RANKL / 骨細胞死 / 異常骨リモデリング / 骨量減少 / 軟骨下骨 / 早期変形性膝関節症 / 加齢性変化 / 加齢 / 変形性関節症 / 局所性レニン・アンギオテンシン系 / 軟骨細胞肥大分化 / 関節軟骨変性 / 局所的レニン・アンギオテンシン系 / 高血圧症 / メタボリックシンドローム / ロコモティブシンドローム / Basic fibroblast growth factor / Life-style related disease / Hyperlipidemia / Lectine-like oxidized lipoproteinreceptor-1(LOX-1) / Oxidized LDL / Cartilage degeneration / Knee Osteoarthritis / LOX-1 / 実験的変形性関節症 / 塩基性線維芽細胞増殖因子(bFGF) / 高脂血症 / レクチン様酸化LDL受容体1(LOX-1) / 酸化LDL / Reactive oxygen species / Mechanical stress / Depolymerization / Hyaluronan / Cartilage / Synovium / Osteoarthrosis / 阻血再潅流 / 活性酸素種 / 関節炎 / ヒアルロン酸合成酵素 / Superoxidedismutase / 軟骨保護作用 / スーパーオキサイドディスムターゼ / 過酸化物質 / フリーラジカル / 分子量 / 活性酸素 / 低分子化 / ヒアルロン酸 / 軟骨 / 滑膜 / 関節症 / 骨粗鬆症 / トランスレーショナルリサ / 細胞・細胞 / 老化 / トランスレーショナルリサーチ / 脂質 / 細胞・組織 / 医療・福祉 / 親規遺伝子 / ATDC5細胞 / Differential Display法 … More Except Principal Investigator 末梢神経再生 / 人工神経 / 同種脱細胞性神経基底膜 / 神経誘導管 / 血管茎 / 骨髄幹細胞 / 同種神経基底膜 / ラット坐骨神経 / 自家脱細胞性筋肉基底膜 / 人工神経誘導管 / 脱細胞化同種神経基底膜 / 脱細胞化自家筋肉基底膜 / 自家無細胞性筋肉基底膜 / 同種無細胞性神経基底膜 / 成長因子 / 足場 / 細胞 / 血行 / 血管 / 同種脱細胞化神経基底膜 / 人工神経鞘 / 毛細血管透過性チューブ / 可溶性チューブ / 血流 / 骨髄間葉系幹細胞 / anti-tumor effects / intramedullary nail / hyperthermia / experimental bone tumor / 実験的転移性骨腫瘍 / 転移性骨腫瘍 / 抗腫瘍効果 / 髄内釘 / ハイパーサーミア / 実験的骨腫瘍 / 同種神経基底膜移植 / チュービング / 骨髄幹細胞移植 / artificial nerve conduit / allogenic nerve / stem cell / vascular bundle Less

Subchondral bone loss in early knee osteoarthritis: osteocyte apoptosis and RANKL expressionPrincipal Investigator
- Principal Investigator
  
  AKAGI Masao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kindai University
Bio-permeable nerve conduits containing isogenic acellular muscle basal lamellae and bone marrow mesenchymal stem cells
- Principal Investigator
  
  KAKINOKI Ryosuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kindai University
Artificial nerves containing allogenic basal lamellae scaffold and bone marrow derived stem cells
- Principal Investigator
  
  KAKINOKI Ryosuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kindai University
Articular cartilage degeneration due to activation of the local renin-angiotensin system (RAS)Principal Investigator
- Principal Investigator
  
  AKAGI Masao
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kindai University
Nerve regeneration through A vessel-containing nerve conduit implanted with bone marrow stromal cells and decellularized allogenic nerve matrix
- Principal Investigator
  
  KAKINOKI Ryosuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kindai University
Effects of local Renin-angiotensin system on development and progression of knee osteoarthritis(OA)Principal Investigator
- Principal Investigator
  
  AKAGI Masao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kinki University
Involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system to joint cartilage degenerationPrincipal Investigator
- Principal Investigator
  
  AKAGI Masao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kinki University
Effects of Hyperlipidemia on Progression of Knee OsteoarthritisPrincipal Investigator
- Principal Investigator
  
  AKAGI Masao
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kinki University
Mechanism of hyaluronan depolymerization due to Reactive oxygen species (ROS) produced by synoviocytes cultured in hypoxia, resulting synovial proliferation.Principal Investigator
- Principal Investigator
  
  AKAGI Masao
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kinki University
Differential Display法による軟骨発生分化制御因子のクローニングPrincipal Investigator
- Principal Investigator
  
  赤木将男
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
Development of a new strategy of hyperthermia for metastatic bone tumor
- Principal Investigator
  
  TSUBOYAMA Tadao, 琴浦良彦
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  KYOTO UNIVERSITY

[Journal Article] Bone marrow-derived mesenchymal stem cells transplanted into a vascularized biodegradable tube containing decellularized allogenic nerve basal laminae promoted peripheral nerve regeneration; can it be an alternative of autologous nerve graft?2021
- Author(s)
  Hiroki Tanaka, Ryosuke Kakinoki, Yukitoshi Kaizawa, Hirofumi Yurie, Ryosuke Ikeguchi, Masao Akagi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 8 Pages: e0254968-e0254968
- DOI
  10.1371/journal.pone.0254968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09493
[Journal Article] Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature2018
- Author(s)
  Kazuhiko Hashimoto, Shunji Nishimura, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi
- Journal Title
  
  Biomedical Research
  
  Volume: 29 Pages: 2718-2721
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] Cyclic compressive loading activates angiotensin II type 1 receptor in articular chondrocytes and stimulates hypertrophic differentiation through a G-protein-dependent pathway.2018
- Author(s)
  Fumihisa Nakamura, Ichiro Tsukamoto, Shinji Inoue, Kazuhiko Hashimoto, Masao Akagi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8 Issue: 6 Pages: 962-973
- DOI
  10.1002/2211-5463.12438
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] Activation of the renin-angiotensin system in mice aggravates mechanical loading-induced knee osteoarthritis2018
- Author(s)
  Yamagishi Kotaro、Tsukamoto Ichiro、Nakamura Fumihisa、Hashimoto Kazuhiko、Ohtani Kazuhiro、Akagi Masao
- Journal Title
  
  European Journal of Histochemistry
  
  Volume: 62 Pages: 177-187
- DOI
  10.4081/ejh.2018.2930
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis: A mini review2018
- Author(s)
  Kazuhiko Hashimoto, Yutaka Oda, Shigeshi Mori, Kotaro Yamagishi, Ichiro Tsukamoto, Masao Akagi
- Journal Title
  
  Journal of Rare Diseases Research & Treatment
  
  Volume: 3 Pages: 22-24
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] Cyclic compressive loading activates AT1 receptor in articular chondrocytes and stimulates hypertrophic differentiation through a G-protein-dependent pathway.2018
- Author(s)
  Nakamura F, Tsukamoto I, Inoue S, Hahimoto K, Akagi M
- Journal Title
  
  FEBS Open Bio
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] LOX-1 deficient mice are resistant to zymosan-induced arthritis: A mini review2018
- Author(s)
  Kazuhiko Hashimoto, Yutaka Oda, Kotaro Yamagishi, Ichiro Tsukamoto, Masao Akagi
- Journal Title
  
  Journal of Immunological Sciences
  
  Volume: 2 Pages: 40-45
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] LOX-1 deficient mice show resistance to zymosan-induced arthritis.2018
- Author(s)
  Hashimoto K, Oda Y, Nakagawa K, Ikeda T, Ohtani K, Akagi M
- Journal Title
  
  Eur J Histochem
  
  Volume: 62 Pages: 2847-2847
- DOI
  10.4081/ejh.2018.2847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis.2017
- Author(s)
  Hashimoto K, Oda Y, Nakamura F, Kakinoki R, Akagi M
- Journal Title
  
  Eur J Histochem
  
  Volume: 61 Pages: 2762-2762
- DOI
  10.4081/ejh.2017.2762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10923
[Journal Article] Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis2016
- Author(s)
  K Hashimoto, S Mori, Y Oda, A Nakano, T Sawamura & M Akagi
- Journal Title
  
  Scand J Rheumatol
  
  Volume: 2 Issue: 5 Pages: 1-11
- DOI
  10.3109/03009742.2015.1135979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01309, KAKENHI-PROJECT-25293063, KAKENHI-PROJECT-16K10923
[Journal Article] 誌説：変形性膝関節症のX線像と痛み：解離はなぜ生じるのか2015
- Author(s)
  赤木將男
- Journal Title
  
  臨床リウマチ
  
  Volume: 27 Pages: 157-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462389
[Journal Article] Activating types 1 and 2 angiotensin II receptors modulates the hypertrophic differentiation of chondrocytes.2013
- Author(s)
  Tsukamoto I, Inoue S, Teramura T, Takehara T, Ohtani K, Akagi M
- Journal Title
  
  FEBS Open Bio
  
  Volume: 3 Pages: 279-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462389
[Journal Article] 強制走行負荷による非侵襲性マウス変形性膝関節症モデルの作成2012
- Author(s)
  橋本和彦、赤木將男
- Journal Title
  
  近畿大学医学雑誌　37：11-20, 2012
  
  Volume: 37 Pages: 11-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591694
[Journal Article] 強制走行負荷による非侵襲性マウス変形性膝関節症モデルの作成2012
- Author(s)
  橋本和彦赤木將男
- Journal Title
  
  近畿大学医学会雑誌
  
  Volume: 37巻第1・2号 Pages: 11-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591694
[Journal Article] Possible Involvement of Oxidized Low-density Lipoprotein with Lectin-like Oxidized Low-density Lipoprotein Receptor 1 in Pathogenesis and Progression of Human Osteoarthritis.2007
- Author(s)
  Masao Akagi, Soya Kanata, Shigeshi Mori, Hiroyuki Itabe, Tatsuya Sawamura, Chiaki Hamanishi
- Journal Title
  
  Osteoarthritis and Cartilage 15(3)
  
  Pages: 281-290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Possible Involvement of Oxidized Low-density Lipoprotein with.Lectin-like Oxidized Low-density Lipoprotein Receptor 1 in Pathogenesis and Progression of Human Osteoarthritis2007
- Author(s)
  Masao Akagi
- Journal Title
  
  Osteoarthritis and Cartilage 15(3)
  
  Pages: 281-290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Possible Involvement of Oxidized Low-density Lipoprotein with Lectin-like Oxidized Low-density Lipoprotein Receptor 1 in Pathogenesis and Progression of Human Osteorthritis2007
- Author(s)
  Masao Akagi, et. al.
- Journal Title
  
  Osteoarthritis and Cartilage 15(3)
  
  Pages: 281-290
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Cyclic Tensile Stretch Load and Oxidized Low Density Lipoprotein Synergistically Induce Lectin-like Oxidized LDL Receptor-1 in Cultured Bovine Chondrocytes,Resulting in Decreased Cell Viability and Glycosaminoglycan Synthesis2006
- Author(s)
  Masao Akagi
- Journal Title
  
  J Orthop.Res 24(8)
  
  Pages: 1782-1790
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Cyclic Tensile Stretch Load and Oxidized Low Density Lipoprotein Synergistically Induce Lectin-like Oxidized LDL Receptor-1 in Cultured Bovine Chondrocytes, Resulting in Decreased Cell Viability and Glycosaminoglycan Synthesis.2006
- Author(s)
  Masao Akagi, et al.
- Journal Title
  
  J Orthop. Res, 24(8)
  
  Pages: 1782-1790
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-γ.2006
- Author(s)
  Sohya Kanata, Masao Akagi, Shunji Nishimura, Sumio Hayakawa, Kohji Yoshida, Tatsuya Sawamura, Hiroshi Munakata, Chiaki Hamanishi
- Journal Title
  
  Biochem Biophy Res Comm 348(3)
  
  Pages: 1003-1010
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Cyclic Tensile Stretch Load and Oxidized Low Density Lipoprotein Synergistically Induce Lectin-like Oxidized LDL Receptor-1 in Cultured Bovine Chondrocytes, Resulting in Decreased Cell Viability and Glycosaminoglycan Synthesis.2006
- Author(s)
  Masao Akagi, Shunji Nishimura, Kohji Yoshida, Takumi Kakinuma, Tatsuya Sawamura, Hiroshi Munakata, Chiaki Hamanishi.
- Journal Title
  
  J Orthop. Res 24(8)
  
  Pages: 1782-1790
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Journal Article] Effects of Hyperlipidemia on Progression of Knee Osteoarthritis2005
- Author(s)
  Akio Nishimura, Masao Akagi, Chiaki Hamanishi
- Journal Title
  
  Med J of Kinki University 30(3,4)
  
  Pages: 93-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Presentation] 加齢マウス変形性膝関節症モデルを用いた早期OAの軟骨下骨の検討2023
- Author(s)
  森下貴文　河尾直之　橋本晃明　墳本一郎　橋本和彦　奥本勝美　梶　博史　赤木將男
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K09443
[Presentation] 早期変形性関節症における軟骨下骨の粗鬆性変化と軟骨変性に高血圧が及ぼす影響2022
- Author(s)
  橋本晃明　墳本一郎　森下貴文　伊藤智彦　橋本和彦　赤木將男
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09443
[Presentation] 老齢マウス変形性膝関節症モデルを用いた発症早期の軟骨下骨の検討2022
- Author(s)
  森下貴文　河尾直之　橋本晃明　墳本一郎　橋本和彦　奥本勝美　梶　博史　赤木將男
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09443
[Presentation] 関節軟骨細胞に発現するAT1レセプターは周期的圧迫負荷により活性化され、軟骨肥大変性を促進する2021
- Author(s)
  橋本晃明　墳本一郎　中村文久　森下貴文　橋本和彦　赤木將男
- Organizer
  第33回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K09443
[Presentation] 骨髄間葉系細胞及び同種基底膜移植により作成した人工神経鞘に関する研究（シンポジウム1：末梢神経再生医療(人工神経含む)）2021
- Author(s)
  柿木良介、田中寛樹、原佑紀子、大谷和裕、赤木將男、貝澤幸俊、淘江宏文、池口良輔
- Organizer
  第32回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09493
[Presentation] 早期膝OAにおける軟骨下骨の変化2020
- Author(s)
  墳本一郎　松村大智　森下貴文　伊藤智彦　橋本晃明　家村駿輝　橋本和彦　赤木將男
- Organizer
  第48回日本関節病学会
- Data Source
  KAKENHI-PROJECT-20K09443
[Presentation] 骨髄間葉系細胞及び同種基底膜移植により作成した人工神経鞘に関する研究2020
- Author(s)
  田中寛樹　柿木良介　貝澤幸俊　淘江宏文　池口良輔　赤木將男
- Organizer
  第47回日本マイクロサージャリー学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09493
[Presentation] 早期膝OAにおける軟骨下骨粗鬆症変化と軟骨変性に局所RASが及ぼす影響2020
- Author(s)
  橋本晃明　墳本一郎　松村大智　森下貴文　伊藤智彦　家村駿輝　橋本和彦　赤木將男
- Organizer
  第48回日本関節病学会
- Data Source
  KAKENHI-PROJECT-20K09443
[Presentation] 骨髄間葉系細胞及び同種基底膜移植により作成した人工神経鞘に関する研究2019
- Author(s)
  田中寛樹　赤木將男　柿木良介
- Organizer
  第30回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10951
[Presentation] 骨髄間葉系細胞及び同種基底膜移植により作成した人工神経鞘に関する研究2019
- Author(s)
  田中寛樹　柿木良介　赤木將男
- Organizer
  第36回中部日本手外科研究会
- Data Source
  KAKENHI-PROJECT-17K10951
[Presentation] PAI-1はマウス軟骨細胞においてIL-1βによる軟骨基質分解に関与する2019
- Author(s)
  森竹章公　河尾直之　石田昌義　岡田清孝　辰巳公平　松尾　理　梶　博史　赤木將男
- Organizer
  第32回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] レニンーアンギオテンシン系の活性化はマウスにおいてメカニカルストレスによる膝変形性関節症を促進させる2018
- Author(s)
  山岸孝太郎　墳本一郎　中村文久　橋本和彦　大谷和裕　赤木將男
- Organizer
  第77回近畿大学医学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] PAI-1欠損はマウス軟骨細胞におけるIL-1βによるMMP活性の増加を抑制する2018
- Author(s)
  森竹章公　河尾直之　石田昌義　岡田清孝　辰巳公平　松尾　理　梶　博史　赤木將男
- Organizer
  第31回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] PAI-1はマウス軟骨細胞におけるIL-1βによるMMP活性の増加に関与する2018
- Author(s)
  森竹章公　河尾直之　石田昌義　梶　博史　赤木將男
- Organizer
  第131回中部日本整形外科災害外科学会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] 骨髄間葉系細胞及び同種基底膜移植により作成した人工神経鞘に関する研究2018
- Author(s)
  田中寛樹　柿木良介　大谷和裕　赤木將男
- Organizer
  第29回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10951
[Presentation] レニンーアンギオテンシン系の活性化はメカニカルストレスによる膝変形性関節症を促進させる2018
- Author(s)
  山岸孝太郎　墳本一郎　中村文久　橋本和彦　赤木將男
- Organizer
  第131回中部日本整形外科災害外科学会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] 関節軟骨細胞に発現するAT1レセプターは周期的圧迫負荷により活性化され、軟骨肥大変性を促進する2018
- Author(s)
  墳本一郎　中村文久　森竹章公　山岸孝太郎　中川晃一　井上紳司　赤木將男
- Organizer
  第46回日本関節病学会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] マウス変形性膝関節症モデルにおける軟骨下骨に対するPAI-1の役割2017
- Author(s)
  森竹章公　河尾直之　岡田清孝　辰巳公平　石田昌義　奥本勝美　松尾　理　梶　博史　赤木將男
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] LOX-1欠損マウスはZymosaw誘発性関節炎に抵抗性を示す2017
- Author(s)
  橋本和彦　森　成志　小田　豊　奥本勝美　赤木將男
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  みやこめっせ（京都）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] Plasminogen activator inhibitor-1(PAI-1)はマウス変形性膝関節症による軟骨下骨減少を抑制する2017
- Author(s)
  森竹章公　河尾直之　岡田清孝　辰巳公平　石田昌義　奥本勝美　松尾　理　赤木將男　梶　博史
- Organizer
  第35回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] LOX-1欠損マウスは関節炎に対して抵抗性を示す2016
- Author(s)
  橋本和彦　森　成志　小田　豊　奥本勝美　赤木將男
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] LOX-1欠損マウスは加齢性変形性膝関節症に対して抵抗性を示す2016
- Author(s)
  橋本和彦　森　成志　小田　豊　奥本勝美　中野厚史　沢村達也　赤木將男
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10923
[Presentation] アンジオテンシンⅡはメカニカルストレスによる変形性関節症を促進させる2015
- Author(s)
  山岸孝太郎　墳本一郎　橋本和彦　赤木將男
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場(富山市)
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25462389
[Presentation] 軟骨細胞肥大分化過程におけるlocal RASと酸化ストレス2014
- Author(s)
  中村文久、墳本一郎、井上紳司、赤木將男
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25462389
[Presentation] 高血圧によるOA変化：つくば高血圧モデルマウスを用いた検討2014
- Author(s)
  山岸孝太郎、墳本一郎、井上紳司、橋本和彦、赤木將男
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25462389
[Presentation] Zymosan誘発性関節炎モデルマウスにおけるLOX-1の滑膜炎と軟骨変性に対する関与の検討2013
- Author(s)
  小田豊、赤木將男、橋本和彦、浜西千秋
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2013-03-01
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 異なる野生型マウスでの強制走行負荷による変形性膝関節症様変化の比較検討2013
- Author(s)
  橋本和彦赤木將男小田豊浜西千秋
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2013-03-02
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] CHARACTERISING NON-SURGICAL MURINE KNEE OSTEOARTHRITIS MODEL PRODUCED BY CONTROLLED FORCED RUNNING2012
- Author(s)
  Hashimoto K, Akagi M
- Organizer
  2012 Osteoarthritis Research Society International (OARSI) World Congress
- Place of Presentation
  スペイン（バルセロナ）
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 強制走行負荷によるマウス変形性膝関節症モデルの検討2012
- Author(s)
  橋本和彦赤木將男岸本英樹浜西千秋寺村岳士小野寺勇太
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋
- Year and Date
  2012-03-09
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] CHARACTERISING NON-SURGICAL MURINE KNEE OSTEOARTHRITIS MODEL PRODUCED BY CONTROLLED FORCED RUNNING2012
- Author(s)
  Hashimoto K, Akagi M
- Organizer
  2012 OARSI World Congress
- Place of Presentation
  Barcelona Spain
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 強制走行負荷によるマウス変形性膝関節症モデルの検討2012
- Author(s)
  赤木將男
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋(ウィル愛知)
- Year and Date
  2012-03-09
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 強制走行負荷によるマウス変形性膝関節症モデルの作成2012
- Author(s)
  橋本和彦、赤木將男、濵西千秋
- Organizer
  第3回　ヒアルロン酸研究会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 走行負荷でのマウス膝関節変形の検討2011
- Author(s)
  赤木將男
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  福岡(ポスター発表)
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 走行負荷でのマウス膝関節変形の検討(ポスター発表)2011
- Author(s)
  橋本和彦赤木將男岸本英樹浜西千秋
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  福岡
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 走行負荷でのマウス膝関節変形の検討2011
- Author(s)
  赤木將男
- Organizer
  第39回日本関節病学会
- Place of Presentation
  横浜(パシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 非侵襲性OAモデルマウスと侵襲性OAモデルマウスの比較検討2011
- Author(s)
  橋本和彦赤木將男岸本英樹浜西千秋寺村岳士小野寺勇太
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 走行負荷でのマウス膝関節変形の検討2011
- Author(s)
  橋本和彦赤木將男岸本英樹浜西千秋寺村岳士小野寺勇太
- Organizer
  第39回日本関節病学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] 非侵襲性OAモデルマウスと侵襲性OAモデルマウスの比較検討2011
- Author(s)
  赤木將男
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋(ベイシア文化ホール)
- Data Source
  KAKENHI-PROJECT-22591694
[Presentation] Oxidized low-density lipoprotein binding to lectin-like oxidized lipoprotein receptor-1(LOX-1) upregulates Vascular endothelial growth factor expression in cultured bovine articular chondrocytes through PPAR-gamma activation2007
- Author(s)
  Sohya Kanata, Masao Akagi, Shunji Nishimura, Akio Nishimura, Shigeki Asada, Shigeshi Mori, Chiaki Hamanishi
- Organizer
  53nd Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Diego, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Presentation] Oxidized-LDL binding to Lectin-like ox-LDL receptor 1(LOX-1) in bovine cultured chondrocytes increases VEGF expression through activation of PPAR-gamma.2006
- Author(s)
  Sohya Kanata, Masao Akagi, Akio Nishimura, Shigeshi Mori, Shigeki Asada, Chiaki Hamanishi
- Organizer
  19th Annual Meeting of the Japanese Society of Cartilage Metabolism
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Presentation] The effects of hyperlipidemic loading on cartilage degeneration in the knee : Experimental studies using a congenital hyperlipidemic rabbit(KHC rabbit)2006
- Author(s)
  Akio Nishimura, Masao Akagi, Sohya Kanata Shigeshi Mori, Shigeki Asada, Chiaki Hamanishi
- Organizer
  19th Annual Meeting of the Japanese Society of Cartilage Metabolism
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Presentation] Presence of oxidized low density lipoprotein(ox-LDL) with lectin-like oxidized lipoprotein receptor-1(LOX-1) correlates to degeneration of human osteoarthritic cartilage.2005
- Author(s)
  Masao Akagi, Muneya Kanata, Akio Nishimura, Shigeshi Mori, Shunji Nishimura, Chiaki Hamanishi.
- Organizer
  10th World Congress of Osteoarthritis Research Society International
- Place of Presentation
  Boston, MA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591602
[Presentation] PRESENCE OF OXIDIZED LOW DENSITY LIPOPROTEIN(OX-LDL)WITH LECTIN-LIKE OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR-1(LOX-1)CORRELATES TO DEGENERATION OF HUMAN OSTEOARTHRITIC CARTILAGE2005
- Author(s)
  Masao Akagi, et. al.
- Organizer
  10th World Congress of Osteoarthritis Research Society International
- Place of Presentation
  Boston,Massachusetts,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591602

1. KAKINOKI Ryosuke (20314198)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. ASADA Shigeki (00330283)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. HASHIMOTO Kazuhiko (10635569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
4. 墳本一郎 (20770051)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. SAWAMURA Tatsuya (30243033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TERAMURA Takeshi (40460901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TSUBOYAMA Tadao (90261221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIRAOKA Masahiro (70173218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SOEN S (10142598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUKUDA K (50201744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NONAKA T (70268407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OH M (20319734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松田秀一 (40294938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 太田壮一 (70592484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 琴浦良彦 (50127081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 岡正典 (20088537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 原文彦 (30340798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 森成志 (80351584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. 西村俊司 (80388545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 井上紳司 (10642879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 中野厚史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKAGI Masao 赤木 將男

Research Projects

Research Products

Co-Researchers

Subchondral bone loss in early knee osteoarthritis: osteocyte apoptosis and RANKL expressionPrincipal Investigator

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Bio-permeable nerve conduits containing isogenic acellular muscle basal lamellae and bone marrow mesenchymal stem cells

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Artificial nerves containing allogenic basal lamellae scaffold and bone marrow derived stem cells

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Articular cartilage degeneration due to activation of the local renin-angiotensin system (RAS)Principal Investigator

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Nerve regeneration through A vessel-containing nerve conduit implanted with bone marrow stromal cells and decellularized allogenic nerve matrix

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Effects of local Renin-angiotensin system on development and progression of knee osteoarthritis(OA)Principal Investigator

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Involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system to joint cartilage degenerationPrincipal Investigator

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Effects of Hyperlipidemia on Progression of Knee OsteoarthritisPrincipal Investigator

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Mechanism of hyaluronan depolymerization due to Reactive oxygen species (ROS) produced by synoviocytes cultured in hypoxia, resulting synovial proliferation.Principal Investigator

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Differential Display法による軟骨発生分化制御因子のクローニングPrincipal Investigator

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Development of a new strategy of hyperthermia for metastatic bone tumor

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[Journal Article] Bone marrow-derived mesenchymal stem cells transplanted into a vascularized biodegradable tube containing decellularized allogenic nerve basal laminae promoted peripheral nerve regeneration; can it be an alternative of autologous nerve graft?2021

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[Journal Article] Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature2018

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[Journal Article] Cyclic compressive loading activates angiotensin II type 1 receptor in articular chondrocytes and stimulates hypertrophic differentiation through a G-protein-dependent pathway.2018

AKAGI Masao 赤木將男