NAKAMURA Kazuhiko 中村和彦

… Alternative Names

中村和彦ナカムラカズヒコ

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Researcher Number	00274449
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2018: 九州大学, 医学研究院, 共同研究員 2016: 九州大学, 大学病院, 講師 2016: 九州大学, 病院・肝臓膵臓胆道内科, 助教 2012 – 2015: 九州大学, 大学病院, 助教 2008 – 2010: Kyushu University, 大学病院, 助教 … More 2007: Kyushu University, Graduate School of Medical Sciences, Assistant Professor 2006: 九州大学, 大学院医学研究院, 助手 2004 – 2005: 九州大学, 大学院・医学研究院, 助手 1998: 九大, 医学部, 助手 1996 – 1997: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / 制御性T細胞 / Smad2 / TGF-β / チロシンキナーゼ / 大腸癌 / 細菌 / 免疫学 / 内科 / 酪酸 … More / 腸内細菌 / immunology / regulatory T cell / inflammatory bowel disease / 免疫 / neutrophil / macrophage / T cell / Inflammatory bowel diseases / コンディショナルノックアウトマウス / 大腸炎 / ノックアウトマウス / 好中球 / マクロファージ / T細胞 / シグナル伝達 / サイトカイン / proinflammatory cytokine / TGF-beta / 炎症性サイトカイン / smad7 / Th17 / 下部消化管学(小腸、大腸) / アンチセンスオリゴヌクレオチド … More Except Principal Investigator Na+/Ca2+交換機転 / 高解像度食道内圧検査 / 細胞内カルシウム / 筋原性筋緊張調節性筋緊張調節 / 食道アカラシア / 食道運動異常症 / 硫化水素 / 筋原性筋緊張調節 / 下部食道括約筋 / アカラシア / alpha-toxin / カルバコール / MLCP / MLCK / K^+脱分極刺激 / 腸管平滑筋 / カルシウム感受性 / 消化管免疫 / 消化管平滑筋 / Th17 / IL-17 / IL-23 Less

Induction of the cell surface-bound TGF-beta on the regulatory T cells by enteric bacteria and its fermentation product.Principal Investigator
- Principal Investigator
  
  Nakamura Kazuhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Investigation of myogenic tone regulation in lower esophageal sphincter to develop novel treatments for achalasia
- Principal Investigator
  
  Ihara Eikichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
The mechanism of increased smad7 expression in the intestinal mucosa of inflammatory bowel disease and the exploitation of a new therapyPrincipal Investigator
- Principal Investigator
  
  Nakamura Kazuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Effects of IL-23 and Th17 on intestinal smooth muscle contractility and its underlying mechanism
- Principal Investigator
  
  IHARA Eikichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Suppression of Th17-inflammation in inflammatory bowel diseases by regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Kazuhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
In vitroexpansion or induction of regulatory T cells from olcerative colitis patientsPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
A study of inflammatory bowel diseases using Smad2 conditional knockout mice.Principal Investigator
- Principal Investigator
  
  NAKAMURA Kazuhiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KYUSHU UNIVERSITY
Src型チロシンキナーゼの大腸癌増殖における役割Principal Investigator
- Principal Investigator
  
  中村和彦
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Src型チロシンキナーゼの大腸癌細胞増殖における役割Principal Investigator
- Principal Investigator
  
  中村和彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University

All 2017 2016 2015 2011 2010 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Diagnosis and Treatment Strategy of Achalasia Subtypes and Esophagogastric Junction Outflow Obstruction Based on High-Resolution Manometry.2017
- Author(s)
  Ihara E, Muta K, Fukaura K, Nakamura K.
- Journal Title
  
  Digestion.
  
  Volume: 95 Issue: 1 Pages: 29-35
- DOI
  10.1159/000452354
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460940
[Journal Article] Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body.2017
- Author(s)
  Xiaopeng B, Tanaka Y, Ihara E, Hirano K, Nakano K, Hirano M, Oda Y, Nakamura K.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 797 Pages: 65-74
- DOI
  10.1016/j.ejphar.2017.01.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460940
[Journal Article] Clinical characteristics associated with esophageal motility function.2016
- Author(s)
  Tanaka Y, Ihara E, Nakamura K, Muta K, Fukaura K, Mukai K, Bai X, Takayanagi R.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 31 Issue: 6 Pages: 1133-1140
- DOI
  10.1111/jgh.13262
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460940
[Journal Article] Effects of Acotiamide on the Esophageal Motility Function in Patients with Esophageal Motility Disorders: A Pilot Study.2016
- Author(s)
  Muta K, Ihara E, Fukaura K, Tsuchida O, Ochiai T, Nakamura K.
- Journal Title
  
  Digestion.
  
  Volume: 94 Issue: 1 Pages: 9-16
- DOI
  10.1159/000447010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460940
[Journal Article] Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter.2015
- Author(s)
  Tanaka Y, Ihara E, Hirano K, Takahashi S, Hirano M, Nakamura K, Akiho H, Oda Y, Takayanagi R
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 752 Pages: 97-105
- DOI
  10.1016/j.ejphar.2015.02.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460940
[Journal Article] CD4^+ FCD25^+ Regulatory T Cells Suppress Th17-Responses in the Experimental Colitis Model.2011
- Author(s)
  Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R
- Journal Title
  
  Digestive Diseases and Sciences 56
  
  Pages: 376-386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590743
[Journal Article] 潰瘍性大腸炎に対する制御性T細胞移入療法の開発2010
- Author(s)
  中村和彦
- Journal Title
  
  消化器内科
  
  Volume: 51 Pages: 341-348
- Data Source
  KAKENHI-PROJECT-20590743
[Journal Article] 潰瘍性大腸炎に対する制御性T細胞移入療法の開発2010
- Author(s)
  中村和彦
- Journal Title
  
  消化器内科 51
  
  Pages: 341-348
- Data Source
  KAKENHI-PROJECT-20590743
[Journal Article] A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice2008
- Author(s)
  Sun, X., Somada, S., Shibata, K., Muta, H., Yamada, H., Yoshihara, H., Honda, K., Nakamura, K., Takayanagi, R., Tani, K., Podack, ER., Yoshikai, Y
- Journal Title
  
  Gastroenterology 134
  
  Pages: 447-458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590685
[Journal Article] Preparation of functionally preserved CD4^+CD25^<high> regulatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell-transfer therapy.2008
- Author(s)
  Sumida Y, Nakamura K, Kanayama K, Akiho H, Teshima T, Takayanagi R
- Journal Title
  
  Cytotherapy 10
  
  Pages: 698-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590743
[Journal Article] An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis2006
- Author(s)
  Takahashi, M., Nakamura, K., Honda, K., Kitamura, Y., Mizutani, T., Araki, Y., Kabemura, T., Chijiiwa, Y., Harada, N., Nawata, H
- Journal Title
  
  Dig Dis Sci 51
  
  Pages: 677-686
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590685
[Journal Article] An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.2006
- Author(s)
  Takahashi M, Nakamura K, Honda K, Kitamura Y, Mizutani T, Araki Y, Kabemura T, Chijiiwa Y, Harada N, Nawata H
- Journal Title
  
  Digestive Diseases and Sciences 51
  
  Pages: 677-686
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590603
[Journal Article] 制御性T細胞をどう治療に生かすか?2006
- Author(s)
  中村和彦
- Journal Title
  
  炎症と免疫 14
  
  Pages: 86-92
- Data Source
  KAKENHI-PROJECT-18590685
[Journal Article] Th1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis.2005
- Author(s)
  Honda K, Nakamura K, Matsui N, Takahashi M, Kitamura Y, Mizutani T, Harada N, Nawata H, Hamano S, Yoshida H
- Journal Title
  
  Inflammatory Bowel Diseases 11
  
  Pages: 1044-1052
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590603
[Journal Article] TGF-β1 plays an important role in the mechanism of CD4^+CD25^+ regulatory T cell activity in both humans and mice.2004
- Author(s)
  Nakamura et al.
- Journal Title
  
  Journal of Immunology 172
  
  Pages: 834-842
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590603
[Journal Article] Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer.2004
- Author(s)
  Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M, Kuroki S, Katano M
- Journal Title
  
  Cancer Research 64
  
  Pages: 6071-6074
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590603
[Journal Article] TGF-β1 plays an important role in the mechanism of CD4^+CD25^+ regulatory T cell activity in both humans and mice.2004
- Author(s)
  Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, Strober W
- Journal Title
  
  Journal of Immunology 172
  
  Pages: 834-842
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590603
[Presentation] Mechanisms of acotiamde-sensitive impaired lower esophageal sphincter accommodation in patients with esophagogastric junction outflow obstruction.2016
- Author(s)
  Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Tsuchida O, Ochiai T, Iwasa T, Aso A, Nakamura K.
- Organizer
  Digestive Disease Week
- Place of Presentation
  San Diego
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] Mechanisms of acotiamide-sensitive impaired lower esophageal sphincter accommodation in patients with esophagogastric junction outflow obstruction2016
- Author(s)
  Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Tsuchida O, Ochiai T, Iwasa T, Aso A and Nakamura K
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  San Diego
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] Actiamide has the potential to become a promising treatment for patients with esophagogastric junction outflow obstruction.2015
- Author(s)
  Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Nakamura K, Ochiai T, Tsuchida O, Akiho H, Takayanagi R.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington DC
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] Clinical characteristics associated with function of esophageal motility: A retrospective analysis of 97 patients.2015
- Author(s)
  Tanaka Y, Ihara E, Muta K, Fukaura K, Mukai K, Bai X, Nakamura K, Akiho H, Takayanagi R.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington DC
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] The cytokine expression patterns of esophageal mucosa are associated with esophageal motility function in human.2015
- Author(s)
  Fukaura K, Ihara E, Muta K, Tanaka Y, Bai X, Nakamura K, Takayanagi R.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington DC
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] Endogenous H2S contributes to myogenic tone generation in lower esophageal sphincter: Possible involvement of Na+/Ca2+ exchanger.2015
- Author(s)
  Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Akiho H, Nakamura K, Takayanagi R.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington DC
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] The development of leukapheresis/regulatory T cell transfer therapy for the treatment of ulcerative colitis : the establishment of aseptic cell isolation protocol2007
- Author(s)
  Sumida, Y., Nakamura, K., Kanayama, K., Takahashi, M., Mizutani, T., Honda, K., Higuchi, N., Ogino, H., Murao, H., Taki, K., Itaba, S., Akiho, H., Takayanagi, R
- Organizer
  JDDW2007
- Place of Presentation
  Kobe
- Year and Date
  2007-10-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590685
[Presentation] Clinical characteristics associated with function of esophageal motility: A retrospective analysis of 97 patients
- Author(s)
  Tanaka Y, Ihara E, Muta K, Fukaura K, Mukai K, Bai X, Nakamura K, Takayanagi R
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington
- Year and Date
  2015-05-16 – 2015-05-20
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] The cytokine expression patterns of esophageal mucosa are associated with esophageal motility function in human.
- Author(s)
  Fukaura K, Ihara E, Muta K, Tanaka Y, Bai X, Nakamura K, Takayanagi R
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington
- Year and Date
  2015-05-16 – 2015-05-20
- Data Source
  KAKENHI-PROJECT-26460940
[Presentation] Endogenous H2S contributes to myogenic tone generation in lower esophageal sphincter: possible involvement of Na+/Ca2+ exchanger
- Author(s)
  Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Nakamura K, Takayanagi R
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Washington
- Year and Date
  2015-05-16 – 2015-05-20
- Data Source
  KAKENHI-PROJECT-26460940

1. IHARA Eikichi (80612390)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. AKIHO Hirotada (10380411)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. MUTA Hiromi (40325478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NOMURA Masatoshi (30315080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

NAKAMURA Kazuhiko 中村 和彦

中村 和彦 ナカムラ カズヒコ

Research Projects

Research Products

Co-Researchers

Induction of the cell surface-bound TGF-beta on the regulatory T cells by enteric bacteria and its fermentation product.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of myogenic tone regulation in lower esophageal sphincter to develop novel treatments for achalasia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of increased smad7 expression in the intestinal mucosa of inflammatory bowel disease and the exploitation of a new therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of IL-23 and Th17 on intestinal smooth muscle contractility and its underlying mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of Th17-inflammation in inflammatory bowel diseases by regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vitroexpansion or induction of regulatory T cells from olcerative colitis patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of inflammatory bowel diseases using Smad2 conditional knockout mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Src型チロシンキナーゼの大腸癌増殖における役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Src型チロシンキナーゼの大腸癌細胞増殖における役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Diagnosis and Treatment Strategy of Achalasia Subtypes and Esophagogastric Junction Outflow Obstruction Based on High-Resolution Manometry.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical characteristics associated with esophageal motility function.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Acotiamide on the Esophageal Motility Function in Patients with Esophageal Motility Disorders: A Pilot Study.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter.2015

NAKAMURA Kazuhiko 中村和彦

中村和彦ナカムラカズヒコ