saegusa chika 三枝智香

… Alternative Names

三枝智香サエグサチカ

Saegusa Chika 三枝智香

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Researcher Number	00280800
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023: 北里大学, 医学部, 講師 2021: 慶應義塾大学, 医学部(信濃町), 共同研究員 2019 – 2021: 慶應義塾大学, 医学部(信濃町), 特任助教 2014 – 2018: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 2005 – 2006: 独立行政法人理化学研究所, 福田独立主幹研究ユニット, ユニット研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / 0906:Surgery related to the biological and sensory functions and related fields / Functional biochemistry / Experimental pathology Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56050:Otorhinolaryngology-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator ヒトiPS細胞 / 2D細胞シート / 難聴 / リボソーム / アミノグリコシド / ミトコンドリア / 耳毒性 / 薬剤スクリーニング / 内耳血管条辺縁細胞 / ヒト多能性幹細胞 … More / 内耳蝸牛 / 血管条辺縁細胞 / 3Dオルガノイド / 多能性幹細胞 / Kチャネル / 内耳血管条 / 分化誘導 / イオン輸送 / バリア機能 / カリウムチャネル / タイトジャンクション / 上皮細胞 / iPS細胞 / 辺縁細胞 / 血管条 / 内耳 / プロテオーム / 質量分析 / エンドサイトーシス / タンパク質間相互作用 / 神経栄養因子 / 神経筋接合部 / ショウジョウバエ / ヘパラン硫酸プロテオグリカン / 外分泌 / 膵臓 / 胃粘液 / Rab27 / シナプトタグミン / ノックアウトマウス / 開口放出 / 小胞輸送 … More Except Principal Investigator 難聴 / 自己免疫 / Precision Medicine / 聴覚医学 / コンパニオン診断 / 橋渡し研究 / メニエール病 / 耳科学 / 神経回路 / 神経栄養因子 / 神経可塑性 / オクトパミン / ショウジョウバエ / グリピカン / シナプス可塑性 / 神経筋接合部 / プロテオグリカン / ヘパラン硫酸 Less

ミトコンドリア難聴患者iPS細胞を用いた難聴発症機構の解明と治療薬探索Principal Investigator
- Principal Investigator
  
  三枝智香
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kitasato University
ヒトiPS細胞からの内耳血管条シート誘導系の樹立とその医用応用Principal Investigator
- Principal Investigator
  
  三枝智香
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Keio University
A precision Medicine for acute sensorineural hearing loss
- Principal Investigator
  
  OGAWA Kaoru
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Keio University
Establishment of method to induce differentiation of human pluripotent stem cells into stria vascularis marginal cells in inner earPrincipal Investigator
- Principal Investigator
  
  Saegusa Chika
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0906:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Keio University
Development of novel therapeutics for autoimmune inner ear disorder by using new transgenic mouse model
- Principal Investigator
  
  Ogawa Kaoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Regulation of Neural Network Formation by Proteoglycans
- Principal Investigator
  
  MAEDA Nobuaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
ショウジョウバエを用いたヘパラン硫酸プロテオグリカン結合蛋白質の網羅的解析Principal Investigator
- Principal Investigator
  
  三枝智香
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
小胞輸送関連遺伝子シナプトタグミン様タンパク質欠損マウスの作製および解析Principal Investigator
- Principal Investigator
  
  三枝智香
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2015 2006 Other

All Journal Article Presentation Patent

[Journal Article] Critical roles of FGF, RA, and WNT signaling in the development of human otic placode and subsequent lineages in a dish2022
- Author(s)
  Saeki, T., Yoshimatsu, S., Ishikawa, M., Shin, JW., Hon, C-C., Shibata, S., Hosoya, M., Saegusa, C., Ogawa, K., Fujioka, M., Okano, H.
- Journal Title
  
  Regen Ther
  
  Volume: 20 Pages: 165-186
- DOI
  10.1016/j.reth.2022.04.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K24038, KAKENHI-PROJECT-20K20409, KAKENHI-PROJECT-21H04839, KAKENHI-PROJECT-21K15112
[Journal Article] Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice2021
- Author(s)
  Nishiyama Takanori、Fujioka Masato、Saegusa Chika、Oishi Naoki、Harada Tatsuhiko、Hosoya Makoto、Saya Hideyuki、Ogawa Kaoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 534 Pages: 921-926
- DOI
  10.1016/j.bbrc.2020.10.073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18744, KAKENHI-PROJECT-19K24038
[Journal Article] Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells.2020
- Author(s)
  Saegusa C, Hosoya M, Nishiyama T, Saeki T, Fujimoto C, Okano H, Fujioka M, Ogawa K.
- Journal Title
  
  Laryngoscope Investig Otolaryngol.
  
  Volume: 5 Issue: 3 Pages: 520-528
- DOI
  10.1002/lio2.392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K24038, KAKENHI-PROJECT-18K09369
[Journal Article] Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation.2019
- Author(s)
  Cheng YF, Chan YH, Hu CJ, Lu YC, Saeki T, Hosoya M, Saegusa C, Fujioka M, Okano H, Weng SM, Hsu CJ, Chang KH, Wu CC.
- Journal Title
  
  Stem Cell Res.
  
  Volume: 40 Pages: 101524-101524
- DOI
  10.1016/j.scr.2019.101524
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24038, KAKENHI-PROJECT-18H04065
[Journal Article] Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells2006
- Author(s)
  Chika Saegusa, Toru Tanaka, Satoru Tani, Shigeyoshi Itohara, Katsuhiko Mikoshiba, Mitsunori Fukuda
- Journal Title
  
  Genes to Cells 11 (6)
  
  Pages: 623-631
- Data Source
  KAKENHI-PROJECT-17790272
[Patent] 内耳有毛細胞の製造方法、薬剤の評価方法、及び細胞分化誘導用組成物2021
- Inventor(s)
  佐伯翼、藤岡正人、三枝智香、細谷誠、岡野栄之他
- Industrial Property Rights Holder
  佐伯翼、藤岡正人、三枝智香、細谷誠、岡野栄之他
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19K24038
[Patent] 内耳前駆細胞の製造方法、内耳有毛細胞の製造方法、薬剤の評価方法、及び内耳細胞分化誘導用組成物2021
- Inventor(s)
  佐伯翼、藤岡正人、三枝智香、細谷誠、岡野栄之他
- Industrial Property Rights Holder
  佐伯翼、藤岡正人、三枝智香、細谷誠、岡野栄之他
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19K24038
[Patent] 内耳血管条辺縁細胞の製造方法、薬剤の評価方法、及び薬剤評価用細胞培養物2021
- Inventor(s)
  三枝智香、藤岡正人、岡野栄之
- Industrial Property Rights Holder
  三枝智香、藤岡正人、岡野栄之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-144125
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] Induced marginal cells of inner ear from human iPS cells as the disease models for hearing loss2021
- Author(s)
  Chika Saegusa, Hiroyuki Ozawa, Hideyuki Okano, Masato Fujioka
- Organizer
  ISSCR Tokyo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] ヒト多能性幹細胞からの血管条辺縁細胞分化誘導系の検討2021
- Author(s)
  三枝智香、細谷誠、藤岡正人、小澤宏之
- Organizer
  第31回日本耳科学会
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] 感覚上皮と内リンパ嚢の免疫学的クロストーク:T細胞依存性感覚上皮特異的自己免疫性難聴トランスジェニックマウスが示すこと2021
- Author(s)
  藤岡正人、水足邦雄、三枝智香、神崎晶
- Organizer
  第1回日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] 当院の難聴遺伝外来における基礎・臨床一体型研究2021
- Author(s)
  藤岡正人、山野邉義晴、吉浜圭祐、細谷誠、三枝智香、小澤宏之、小崎健次郎、松永達雄
- Organizer
  第66回日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] 網羅的遺伝子発現解析による新規自己免疫性難聴モデルマウスの分子生物学的検討2020
- Author(s)
  三枝智香、藤岡正人、細谷誠、神崎晶、小川郁
- Organizer
  第30回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] ヒト多能性幹細胞からの血管条辺縁細胞分化誘導系の確立2019
- Author(s)
  三枝智香　細谷誠　藤岡正人　佐伯翼　小川郁
- Organizer
  第29回　日本耳科学会
- Data Source
  KAKENHI-PROJECT-19K24038
[Presentation] ショウジョウバエにおけるヘパラン硫酸プロテオグリカン結合タンパク質の網羅的解析2015
- Author(s)
  三枝智香、神村圭亮、進藤真由美、前田信明
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際展示場 (兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26650041
[Presentation] ショウジョウバエにおけるヘパラン硫酸プロテオグリカン結合タンパク質の網羅的解析
- Author(s)
  三枝智香、神村圭亮、進藤真由美、前田信明
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館 (京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26650041

1. MAEDA Nobuaki (90202308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Ogawa Kaoru (00169179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 神崎晶 (50286556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 藤岡正人 (70398626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 神村圭亮 (30529524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 細谷誠 (30645445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 西山崇経

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

saegusa chika 三枝 智香

三枝 智香 サエグサ チカ

Saegusa Chika 三枝 智香

Research Projects

Research Products

Co-Researchers

ミトコンドリア難聴患者iPS細胞を用いた難聴発症機構の解明と治療薬探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトiPS細胞からの内耳血管条シート誘導系の樹立とその医用応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A precision Medicine for acute sensorineural hearing loss

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of method to induce differentiation of human pluripotent stem cells into stria vascularis marginal cells in inner earPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutics for autoimmune inner ear disorder by using new transgenic mouse model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of Neural Network Formation by Proteoglycans

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ショウジョウバエを用いたヘパラン硫酸プロテオグリカン結合蛋白質の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞輸送関連遺伝子シナプトタグミン様タンパク質欠損マウスの作製および解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Critical roles of FGF, RA, and WNT signaling in the development of human otic placode and subsequent lineages in a dish2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells2006

Author(s)

Journal Title

Data Source

[Patent] 内耳有毛細胞の製造方法、薬剤の評価方法、及び細胞分化誘導用組成物2021

Inventor(s)

saegusa chika 三枝智香

三枝智香サエグサチカ

Saegusa Chika 三枝智香

[Patent] 内耳前駆細胞の製造方法、内耳有毛細胞の製造方法、薬剤の評価方法、及び内耳細胞分化誘導用組成物2021