Kezuka Takeshi 毛塚剛司

… Alternative Names

KEZUKA Takeshi 毛塚剛司

毛塚剛司ケヅカタケシ

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Researcher Number	00287137
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 兼任教授
Affiliation (based on the past Project Information) *help	2012 – 2016: 東京医科大学, 医学部, 准教授 2011: 東京医科大学, 医学部, 講師 2010: 東京医科大学, 医学部, 准教授 2002 – 2008: 東京医科大学, 医学部, 講師 2001: 東京医科大学, 医学部, 助手 1997: 東京医大, 医学部, 助手
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator CGRP / アストロサイト / 視神経脊髄炎 / 遺伝子治療 / ぶどう膜炎 / 神経ペプチド / 遅延型過敏反応 / IL-10 / マクロファージ / 実験的自己免疫性ぶどう膜網膜炎 … More / DENDRITIC CELL / GENE THERAPY / UVEITIS / 成熟樹状細胞 / GFAP / 樹状細胞療法 / タンパク解析 / マウス実験的自己免疫性視神経炎 / 二次元電気泳動 / 抗アクアポリン4抗体陽性視神経炎 / アクアポリン4抗体 / マイクログリア / Myelin/oligodendrocyte glycoprotein / 自己免疫性視神経炎 / 免疫制御 / 実験的自己免疫性視神経炎 / 抗MOG抗体 / 抗アクアポリン４抗体 / 多発性硬化症 / 抗 MOG 抗体 / 抗アクアポリン4抗体 / 細胞治療 / 免疫制御療法 / 視神経炎 / 樹状細胞 / 難治性視神経炎 / 制御性細胞 / 難治性ぶどう膜炎 / 遺伝子導入細胞 / VIP / 実験的自己免疫性ぶどう膜炎 … More Except Principal Investigator experimental autoimmune uveitis / chemokine / microarray / autoimmune disease / uveitis / Behcet's disease / 実験的自己免疫性ぶどう膜炎 / マイクロアレイ / ケモカイン / 自己免疫病 / ぶどう膜炎 / ベーチェット病 / 制御性Ｔ細胞 / サイトカイン / 末梢血リンパ球 / Vogt-小柳‐原田病 Less

Basic approach to elucidate pathogenesis and develop innovative therapy for anti-aquapolin-4 seropositive optic neuritis.Principal Investigator
- Principal Investigator
  
  KEZUKA TAKESHI
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
Vogt-小柳-原田病難治例の治療前判断と予後改善ための免疫学的研究
- Principal Investigator
  
  奥貫陽子
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
Suppression of murine experimental autoimmune optic neuritis byinnovation of mature dendritic cells transfected with calcitoningene-related peptide genePrincipal Investigator
- Principal Investigator
  
  KEZUKA Takeshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
Development of CGRP-gene-transfected immune regulatory cells for treatment of refractory uveoretinitis in humanPrincipal Investigator
- Principal Investigator
  
  KEZUKA Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
SUPPRESSION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS BY NEUROPEPTIDE GENE-TRANSFECT-CELLSPrincipal Investigator
- Principal Investigator
  
  KEZUKA Takeshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  TOKYO MEDICAL UNIVERSITY
Identification of the gene expression profile specific for Behcet's disease with uveitis and the functional analysis
- Principal Investigator
  
  TAKEUCHI Masaru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
神経ペプチド(VIP)による免疫寛容の誘導と実験的ぶどう膜炎の抑制機構の解明Principal Investigator
- Principal Investigator
  
  毛塚剛司
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
神経ペプチド(CGRP)による前房内免疫制御システムの解明と応用Principal Investigator
- Principal Investigator
  
  毛塚剛司
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University
実験的自己免疫性ぶどう膜網膜炎の発症機構におけるアポトーシスの関与Principal Investigator
- Principal Investigator
  
  毛塚剛司
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Medical University

[Book] Acute retinal necrosis.Immune Response and the Eye. Chem Immunol Allergy 92(Niederkorn JY, Kaplan HJ (eds))2007
- Author(s)
  Kezuka T., Atherton SS.(分担執筆)
- Total Pages
  10
- Publisher
  Basel, Karger
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Book] Acute retinal necrosis. Niederkorn JY, Kaplan HJ (eds) : Immune Response and the Eye. Chem Immunol Allergy 922007
- Author(s)
  Kezuka T., Atherton SS.(分担執筆)
- Total Pages
  10
- Publisher
  Basel, Karger
- Data Source
  KAKENHI-PROJECT-17591855
[Book] Acute retinal necrosis(92, Review)2007
- Author(s)
  Kezuka T, Atherton SS
- Publisher
  Chem Immunol Allergy
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] 【視神経症と自己抗体との関連】抗MOG抗体　眼科の立場から2017
- Author(s)
  毛塚　剛司
- Journal Title
  
  眼科
  
  Volume: 59 Pages: 7-12
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 視神経炎．特集/眼科における薬物療法パーフェクトガイド．2017
- Author(s)
  毛塚　剛司
- Journal Title
  
  MB OCULI.
  
  Volume: 48 Pages: 128-133
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 【視神経炎と視神経症:全身と眼の架け橋】眼科臨床における視神経炎と視神経症の位置づけ2016
- Author(s)
  毛塚　剛司
- Journal Title
  
  あたらしい眼科
  
  Volume: 33 Pages: 617-631
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] Clinical profile of anti-myelin oligodendrocyte glycoprotein antibody seropositive cases of optic neuritis.2015
- Author(s)
  Matsuda R, Kezuka T, Umazume A, Okunuki Y,Goto H, Tanaka K.
- Journal Title
  
  Neuro-Ophthalmology
  
  Volume: 39 Issue: 5 Pages: 213-219
- DOI
  10.3109/01658107.2015.1072726
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 自己免疫性視神経炎．2015
- Author(s)
  毛塚剛司
- Journal Title
  
  別冊日本臨牀　新領域別症候群シリーズ No.34 免疫症候群（I）（第2版）
  
  Volume: 34 Pages: 530-534
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 視神経炎の病態理解と治療方針．診療指針のパラダイムシフト．2014
- Author(s)
  毛塚剛司
- Journal Title
  
  眼科
  
  Volume: 56 Pages: 272-276
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 抗AQP4抗体陽性視神経炎2014
- Author(s)
  毛塚　剛司
- Journal Title
  
  眼科
  
  Volume: 56 Pages: 929-934
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 抗アクアポリン4抗体陽性視神経炎．　特集 / 視神経炎のよりよい治療2014
- Author(s)
  毛塚　剛司
- Journal Title
  
  MB OCULI.
  
  Volume: 13 Pages: 26-29
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 視神経脊髄炎　神経眼科における免疫学的進歩2014
- Author(s)
  毛塚　剛司
- Journal Title
  
  神経眼科
  
  Volume: 31 Pages: 5-12
- Open Access
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod.2013
- Author(s)
  An X, Kezuka T, Usui Y, Matsunaga Y, Matsuda R, Yamakawa N, Goto H.
- Journal Title
  
  J Neuroophthalmol.
  
  Volume: 33 Issue: 2 Pages: 143-8
- DOI
  10.1097/wno.0b013e31828ea2fc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] Suppression of Experimental Autoimmune Optic Neuritis by the Novel Agent Fingolimod.2013
- Author(s)
  An X, Kezuka T, Usui Y, Matsunaga Y, Matsuda R, Yamakawa N, Goto H
- Journal Title
  
  J Neuroophthalmol.
  
  Volume: (印刷中)
- URL
  http://journals.lww.com/jneuro-ophthalmology/toc/publishahead
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] 視神経炎をみたら．特集: 神経眼科Minimum Requirements.2013
- Author(s)
  毛塚剛司
- Journal Title
  
  あたらしい眼科
  
  Volume: 30 Pages: 731-737
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 視神経炎-免疫学的アプローチによる病態の解明と新規治療法の開発-2013
- Author(s)
  毛塚剛司
- Journal Title
  
  第116回日本眼科学会総会評議員指名講演 III 日眼会誌
  
  Volume: 117 Pages: 270-91
- NAID
  10031155927
- URL
  http://journal.nichigan.or.jp/PastContent?year=2013&vol=117&number=3&mag=0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] 第116回　日本眼科学会総会　評議員会指名講演III　神経眼科の進歩　視神経炎　―免疫学的アプローチによる病態の解明と新規治療法の開発－2013
- Author(s)
  毛塚剛司
- Journal Title
  
  日眼会誌
  
  Volume: 117 Pages: 270-292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462760
[Journal Article] 第116回日本眼科学会総会評議員会指名講演III. 神経眼科の進歩. 視神経炎 ―免疫学的アプローチによる病態の解明と新規治療法の開発―2013
- Author(s)
  毛塚　剛司
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 117 Pages: 270-292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] Interleukin-10 gene-transfected mature dendritic cells suppress murineexperimental autoimmune optic neuritis2012
- Author(s)
  Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, et al
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 53 Issue: 11 Pages: 7235-7245
- DOI
  10.1167/iovs.12-10587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23792007
[Journal Article] Visual functional and histopathological correlation in experimental autoimmune optic neuritis2012
- Author(s)
  Matsunaga Y, Kezuka T, An X, Fujita K,Matsuyama N, Matsuda R, et al
- Journal Title
  
  Invest Ophthalmol VisSci
  
  Volume: 53 Issue: 11 Pages: 6964-6971
- DOI
  10.1167/iovs.12-10559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967, KAKENHI-PROJECT-23390087, KAKENHI-PROJECT-23659192, KAKENHI-PROJECT-23659626
[Journal Article] Relationship Between NMO-Antibody and Anti-MOG Antibody in Optic Neuritis2012
- Author(s)
  Kezuka T
- Journal Title
  
  J Neuroophthalmol
  
  Volume: 32(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] Relationship between NMO-antibody and anti-MOG antibody in optic neuritis2012
- Author(s)
  Kezuka T, Usui Y, Yamakawa N, Matsunaga Y, Matsuda R, Masuda M, et al
- Journal Title
  
  J Neuroophthalmol
  
  Volume: 32 Issue: 2 Pages: 107-110
- DOI
  10.1097/wno.0b013e31823c9b6c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related peptide gene2012
- Author(s)
  Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, et al
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 53 Issue: 9 Pages: 5475-5485
- DOI
  10.1167/iovs.12-9935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23792007
[Journal Article] Clinical relevance of the relationship between anti-aquaporin 4 antibody and anti-MOG antibody in optic neuritis.2011
- Author(s)
  Kezuka T, Usui Y, Yamakawa N., et al.
- Journal Title
  
  J Neuro-ophthalmol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] Analysis of the pathogenesis of experimental autoimmune optic neuritis2011
- Author(s)
  Kezuka T, Usui Y, Goto H.
- Journal Title
  
  J Biomed Biotechnol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] 【眼科診療:5年前の常識は,現在の非常識!】神経,外眼部,腫瘍などの疾患神経視神経炎の分類・診断・治療2011
- Author(s)
  毛塚剛司
- Journal Title
  
  臨床眼科
  
  Volume: 65 Pages: 390-393
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] Analysis of the pathogenesis of experimental autoimmune optic neuritis.2011
- Author(s)
  Kezuka T, Usui Y, Goto H
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Issue: 1 Pages: 294046-294046
- DOI
  10.1155/2011/294046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] 自己免疫性視神経炎2010
- Author(s)
  毛塚剛司
- Journal Title
  
  神経眼科
  
  Volume: 27 Pages: 429-435
- Data Source
  KAKENHI-PROJECT-22591967
[Journal Article] Angiotensin II type 1 receptor blocker telmisartan suppresses experimental autoimmune uveitis2009
- Author(s)
  Okunuki Y, Usui Y, Nagai N, Kezuka T, Ishida S, Takeuchi M, Goto H
- Journal Title
  
  Invest Ophthalmol Vis Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism2009
- Author(s)
  Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S
- Journal Title
  
  Invest Ophthalmol Vis Sci 50
  
  Pages: 263-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Increased levels of monokine induced by interferon-gamma (Mig) in the vitreous of patients with diabetic retinopathy2008
- Author(s)
  Wakabayashi Y, Usui Y, Okunuki Y, Takeuchi M, Kezuka T, Iwasaki T, Goto H
- Journal Title
  
  Diabet Med 25
  
  Pages: 875-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Acute retinal necrosis in Japan2008
- Author(s)
  Usui Y, Takeuchi M, Goto H, Mori H, Kezuka T, Sakai J, Usui M
- Journal Title
  
  Ophthalmology 115
  
  Pages: 1632-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Functional expression of B7H1 on retinal pigment epithelial cells2008
- Author(s)
  Usui Y, Okunuki Y, Hattori T, Kezuka T, Keino H, Ebihara N, Sugita S, Usui M, Goto H, Takeuchi M
- Journal Title
  
  Exp Eye Res 86
  
  Pages: 52-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Proteomic surveillance of retinal autoantigens in endogenous uveitis : implication of esterase D and brain-type creatine kinase as novel autoantigens2008
- Author(s)
  Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M
- Journal Title
  
  Mol Vis 14
  
  Pages: 1094-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Circulating neutrophils in Behcet disease is resistant for apoptotic cell death in the remission phase of uveitis2008
- Author(s)
  Fujimori K, Oh-i K, Takeuchi M, Yamakawa N, Hattori T, Kezuka T, Keino H, Suzuki J, Goto H, Sakai J, Usui M
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol 246
  
  Pages: 285-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Kaplan HJ (eds) : Immune Response and the Eye.2007
- Author(s)
  Kezuka T., Atherton SS.Acute retinal necrosis.Niederkorn JY
- Journal Title
  
  Chem Immunol Allergy 92
  
  Pages: 244-253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease2007
- Author(s)
  Okunuki Y, Usui Y, Takeuchi M, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Usui M, Nishioka K,Kato T
- Journal Title
  
  Exp Eye Res 84
  
  Pages: 823-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592041
[Journal Article] Intravitoreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in rats.2007
- Author(s)
  Oh-i K., Keino H., Goto H., Yamakawa N., Murase K., Usui Y., Kezuka T., Sakai J., Takeuchi M., Usui M.
- Journal Title
  
  Br J Ophthalmol 91
  
  Pages: 237-242
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Supplementation of CD4+CD25+ regulatory T cells suppress experimental autoimmune uveoretinitis.2007
- Author(s)
  Keino H., Takeuchi M., Usui Y., Hattori T., Yamakawa N., Kezuka T., Sakai J-I, Usui M.
- Journal Title
  
  Br J Ophthalmol 91
  
  Pages: 105-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Expression of costimulatory molecules on human retinoblastoma cells Y-79 : Functional expression of CD40 and B7H1.2006
- Author(s)
  Usui Y., Okunuki Y., Hattori T., Takuchi M., Kezuka T., Goto H., Usui M.
- Journal Title
  
  Invest Ophthal Vis Sci 47
  
  Pages: 4607-4613
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.2006
- Author(s)
  Usui Y., Akiba H., Takeuchi M., Kezuka T., Takeuchi A., Hattori T., Okunuki Y., Yamasaki T., Yagita H., Usui M., Okumura K
- Journal Title
  
  Eur J Immunol 36
  
  Pages: 3071-3081
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Evidence that Regulator T cells of Eye-Derived Tolerance Can Arise from CD25-Negative Precursors.2006
- Author(s)
  Keino H, Takeuchi M, Kezuka T, Hattori T, Usui M, Taguchi O, Streilein JW.
- Journal Title
  
  Investigative Ophthalmology and Visual Science 47(3)
  
  Pages: 1047-1055
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.2006
- Author(s)
  Usui Y., Akiba H., Takeuchi M., Kezuka T., Takeuchi A., Hattori T., Okunuki Y., Yamasaki T., Yagita H., Usui M., Okumura K.
- Journal Title
  
  Eur J Immunol 36
  
  Pages: 3071-3081
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells.2006
- Author(s)
  Keino H, Takeuchi M, Kezuka T, Hattori T, Usui M, Taguchi O, Streilein JW
- Journal Title
  
  Investigative Ophthalmology and Visual Science 47(3)
  
  Pages: 1047-55
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells.2006
- Author(s)
  Keino H., Takeuchi M., Kezuka T., Hattori T., Usui M., Taguchi O., Streilein JW., Streilein JS.
- Journal Title
  
  Invest Ophthal Vis Sci 47
  
  Pages: 1047-1055
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Possibility of inducing anterior chamber-associated immune deviation by TGF-β2 treatment of monocytes isolated from Behcets patients.2006
- Author(s)
  Takeuchi M., Keino H., Suzuki J., Usui Y., Hattori T., Takeuchi A., Oh-i K., Okunuki Y., Kezuka T., Usui M.
- Journal Title
  
  Exp Eye Res 83
  
  Pages: 981-988
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591855
[Journal Article] Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvement.2005
- Author(s)
  Takeuchi M, Hokama H, Tsukahara R, Kezuka T, Goto F, Sakai JI, Usui M
- Journal Title
  
  Graefe's Archive for Clinical and Experimental Ophthalmology 28
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.2005
- Author(s)
  Takeuchi A, Usui Y, Takeuchi M, Hattori T, Kezuka T, Suzuki J, Okunuki Y, Iwasaki T, Haino M, Matsushima K, Usui M.
- Journal Title
  
  Investigative Ophthalmology and Visual Science 46(10)
  
  Pages: 3753-3760
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context effector response.2005
- Author(s)
  Takeuchi A, Usui Y, Takeuchi M, Hattori T, Kezuka T, Suzuki J, Okunuki Y, Iwasaki T, Haino M, Matsushima K, Usui M
- Journal Title
  
  Investigative Ophthalmology and Visual Science 46(10)
  
  Pages: 3753-60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.2005
- Author(s)
  Tsukahara R, Takeuchi M, Akiba H, Kezuka T, Takeda K, Usui Y, Usui M, Yagita H, Okumura K.
- Journal Title
  
  International immunology 17(5)
  
  Pages: 523-30
- NAID
  10019359132
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.2005
- Author(s)
  Tsukahara R, Takeuchi M, Akiba H, Kezuka T, Takeda K, Usui Y, Usui M, Yagita H, Okumura K.
- Journal Title
  
  International Immunology 17(5)
  
  Pages: 523-530
- NAID
  10019359132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvement.2005
- Author(s)
  Takeuchi M, Hokama H, Tsukahara R, Kezuka T, Goto H, Sakai JI, Usui M.
- Journal Title
  
  Graefe's Archive for Clinical and Experimental Ophthalmology 28
  
  Pages: 1-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10.2004
- Author(s)
  Kezuka T, Takeuchi M, Keino H, et al.
- Journal Title
  
  Journal of Immunology 173(2)
  
  Pages: 1454-1462
- Data Source
  KAKENHI-PROJECT-15791009
[Journal Article] Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice.2004
- Author(s)
  Takeuchi M, Kezuka T, Usui M, Taguchi O.
- Journal Title
  
  Investigative Ophthalmology and Visual Science 45(6)
  
  Pages: 1879-86
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] Immune response to retinal self-antigens in Cd25(+)CD4(+) regulatory T cell depleted mice2004
- Author(s)
  Takeuchi M, Keino H, Kezuka T, et al.
- Journal Title
  
  Investigative Ophthalmology & Visual Science 45(6)
  
  Pages: 1879-1886
- Data Source
  KAKENHI-PROJECT-15791009
[Journal Article] Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10.2004
- Author(s)
  Kezuka T, Takeuchi M, Keino H, Usui Y, Takeuchi A, Yamakawa N, Usui M
- Journal Title
  
  Journal of Immunology 173(2)
  
  Pages: 1454-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Journal Article] 水痘帯状庖疹ウイルスによる眼炎症と免疫特異性2004
- Author(s)
  毛塚剛司
- Journal Title
  
  日本眼科学会雑誌 108巻11号
  
  Pages: 649-653
- Data Source
  KAKENHI-PROJECT-15791009
[Journal Article] Prevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptide.2004
- Author(s)
  Keino H, Kezuka T, Takeuchi M, Yamakawa N, Hattori T, Usui M
- Journal Title
  
  Archive Ophthalmology 122(8)
  
  Pages: 1179-1184
- Data Source
  KAKENHI-PROJECT-15791009
[Journal Article] Immune deviation and ocular infections with varicella zoster virus.2004
- Author(s)
  Kezuka T
- Journal Title
  
  Ocular Immunology & Inflammation 12(1)
  
  Pages: 17-24
- Data Source
  KAKENHI-PROJECT-15791009
[Journal Article] Prevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptide.2004
- Author(s)
  Keino H, Kezuka T, Takeuchi M, Yamakawa N, Hattori T, Usui M
- Journal Title
  
  Archives Ophthalmology 122(8)
  
  Pages: 1179-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591769
[Presentation] 抗ミエリンオリゴデンドロサイトグリコプロテイン抗体陽性視神経炎の診断と治療2016
- Author(s)
  毛塚剛司、石川均、後関利明、三村治、吉冨健志、敷島敬悟、平岡美紀、中馬秀樹、中村誠、田中惠子、抗MOG抗体陽性視神経炎調査班
- Organizer
  第70回日本臨床眼科学会
- Place of Presentation
  京都
- Year and Date
  2016-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 視神経炎の薬物療法 update ―薬物療法の選び方―　サブスペシャリティサンデー2016
- Author(s)
  毛塚　剛司
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-04-07
- Invited
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 視神経炎における血清抗アクアポリン4抗体測定法の比較検討．2016
- Author(s)
  毛塚剛司、藤田聖也、馬詰朗比古、臼井嘉彦、後藤浩
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-04-07
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] Comparison of antibody detection assays for serum anti-aquaporin-4 antibodies in optic neuritis.2016
- Author(s)
  Kezuka T, Fujita M, Umazume A, Usui Y, Goto H.
- Organizer
  American Academy of Ophthalmology (AAO) Meeting 2016,
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-10-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] Characterization of microcystic macular edema in patients with optic neuritis.2015
- Author(s)
  Kezuka T, Matsunaga Y, Umazume A, Goto H.
- Organizer
  AAO annual meeting 2015.
- Place of Presentation
  Las Vegas, USA.
- Year and Date
  2015-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 視神経疾患の最前線：視神経炎治療の最前線2015
- Author(s)
  毛塚剛司
- Organizer
  第69回日本臨床眼科学会　モーニングクルズス
- Place of Presentation
  名古屋
- Year and Date
  2015-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 臨床眼科学：今が旬！　視神経炎の今2015
- Author(s)
  毛塚剛司
- Organizer
  第69回日本臨床眼科学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 視神経炎における血清中ミエリン塩基性タンパク濃度と視機能異常との関係．2015
- Author(s)
  毛塚剛司、藤田聖也、馬詰朗比古、野田知子、奥貫陽子、後藤浩．
- Organizer
  第53回日本神経眼科学会総会
- Place of Presentation
  大宮
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] Clinical Update in optic Nerve Disorders.2014
- Author(s)
  Wang A.G, Chuenkongkaew W, Ahn H, Kezuka T, Kashii S, Chan J, Hashimoto M.
- Organizer
  XXXIV International Congress of Ophthalmology (WOC2014).
- Place of Presentation
  Tokyo
- Year and Date
  2014-04-02
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] ぶどう膜炎と関係する視神経症2014
- Author(s)
  毛塚　剛司
- Organizer
  日本眼科学会総会サブスペシャリティサンデー
- Place of Presentation
  東京
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 視神経脊髄炎―発症の関連抗体と新規治療法―2013
- Author(s)
  毛塚　剛司
- Organizer
  第117回　日本眼科学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Interleukin - 10 g ene t ransfected r egulatory d endritic c ells s uppress murine experimental autoimmune optic neuritis2012
- Author(s)
  Matsuda R , Kezuka T, et al .
- Organizer
  ARVO 2012 Annual Meeting
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Suppression of Experimental Autoimmune Optic Neuritis By The Novel Agent FTY7202012
- Author(s)
  Kezuka, T
- Organizer
  ARVO 2012 Annual Meeting
- Place of Presentation
  Fort Lauderdale, Florida, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Correlation between visual evoked potential and histopathology in experimental autoimmune optic neuritis2012
- Author(s)
  Matsunaga Y, Kezuka T, et al
- Organizer
  ARVO 2012 Annual Meeting
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Suppression of experimental autoimmune optic neuritis by the novel agent FTY7202012
- Author(s)
  Kezuka, T et al.
- Organizer
  ARVO 2012 Annual Meeting
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] 評議員会指名講演III. 神経眼科の進歩. 視神経炎免疫学的アプローチによる病態の解明と新規治療法の開発-2012
- Author(s)
  毛塚剛司
- Organizer
  第116回日本眼科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] 評議員会指名講演III. 神経眼科の進歩. 視神経炎 ―免疫学的アプローチによる病態の解明と新規治療法の開発―2012
- Author(s)
  毛塚　剛司
- Organizer
  第116回　日本眼科学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Peripheral blood mononuclear cell cytokine production and response to steroid therapy in patients with optic neuritis2011
- Author(s)
  Kezuka T, et al
- Organizer
  ARVO 2011 AnnualMeeting
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Humoral factor profile in cerebrospinal fluid of patients with optic neuritis2011
- Author(s)
  Kezuka T, et al
- Organizer
  American Academy of Ophthalmology (AAO) annual meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] Peripheral blood mononuclear cell cytokine production and response to steroid therapy in patients with optic neuritis2011
- Author(s)
  Kezuka T
- Organizer
  ARVO
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] 遺伝子導入免疫制御細胞による実験的自己免疫性視神経炎の抑制2010
- Author(s)
  松田隆作、毛塚剛司、臼井義彦, 他
- Organizer
  第48回日本神経眼科学会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] 遺伝子導入免疫制御細胞による実験的自己免疫性視神経炎の抑制2010
- Author(s)
  松田隆作、毛塚剛司、臼井嘉彦他
- Organizer
  第48回日本神経眼科学会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22591967
[Presentation] ラット胎児胸腺移植ヌードマウスを用いた自己免疫生ぶどう膜炎の発症メカニズムの解析2008
- Author(s)
  竹内大、服部貴明、臼井嘉彦、奥貫陽子、馬娟、山川直之、張リナ、毛塚剛司、後藤浩、田口修
- Organizer
  第112回日本眼科学会
- Place of Presentation
  横浜
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19592041
[Presentation] Gene therapy with calcitonin gene-related peptide suppresses murine experimental autoimmune uveoretinitis.2008
- Author(s)
  Kezuka, T., et al.
- Organizer
  ARVO 2008
- Place of Presentation
  米国フロリダ
- Data Source
  KAKENHI-PROJECT-19592041
[Presentation] Gene therapy with calcitonin gene-related peptide suppresses murine experimental autoimmune uveoretinitis2008
- Author(s)
  Kezuka, T. et al
- Organizer
  ARVO 2008
- Data Source
  KAKENHI-PROJECT-19592041
[Presentation] The mechanisms by which spontaneous development of organ-localized autoimmune diseases induced by xenogenic thymus2008
- Author(s)
  Takeuchi M, Hattori T, Usui Y, Okunuki Y, Ma J, Yamakawa N, Zhang T, Kezuka T, Goto H, Taguchi O
- Organizer
  ARVO 2008
- Data Source
  KAKENHI-PROJECT-19592041
[Presentation] 視神経炎症例におけるmicrocystic macular edemaの検討
- Author(s)
  松永芳径、毛塚剛司、佐々一壽、松田隆作、渡辺裕士、田澤聖子、後藤浩
- Organizer
  第118回日本眼科学会総会
- Place of Presentation
  Tokyo
- Year and Date
  2014-04-02 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-25462760
[Presentation] 神経眼科における免疫学的進歩.　視神経脊髄炎―発症の関連抗体と新規治療法.
- Author(s)
  毛塚剛司
- Organizer
  第117回日本眼科学会総会　シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25462760

1. TAKEUCHI Masaru (40260939)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
2. USUI Yoshihiko (50408142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. 松永芳径 (20421050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 奥貫陽子 (40459508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kezuka Takeshi 毛塚 剛司

KEZUKA Takeshi 毛塚 剛司

毛塚 剛司 ケヅカ タケシ

Research Projects

Research Products

Co-Researchers

Basic approach to elucidate pathogenesis and develop innovative therapy for anti-aquapolin-4 seropositive optic neuritis.Principal Investigator

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Vogt-小柳-原田病難治例の治療前判断と予後改善ための免疫学的研究

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Suppression of murine experimental autoimmune optic neuritis byinnovation of mature dendritic cells transfected with calcitoningene-related peptide genePrincipal Investigator

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Development of CGRP-gene-transfected immune regulatory cells for treatment of refractory uveoretinitis in humanPrincipal Investigator

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SUPPRESSION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS BY NEUROPEPTIDE GENE-TRANSFECT-CELLSPrincipal Investigator

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Identification of the gene expression profile specific for Behcet's disease with uveitis and the functional analysis

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神経ペプチド(VIP)による免疫寛容の誘導と実験的ぶどう膜炎の抑制機構の解明Principal Investigator

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神経ペプチド(CGRP)による前房内免疫制御システムの解明と応用Principal Investigator

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実験的自己免疫性ぶどう膜網膜炎の発症機構におけるアポトーシスの関与Principal Investigator

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[Book] Acute retinal necrosis.Immune Response and the Eye. Chem Immunol Allergy 92(Niederkorn JY, Kaplan HJ (eds))2007

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Total Pages

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Description

Data Source

[Book] Acute retinal necrosis. Niederkorn JY, Kaplan HJ (eds) : Immune Response and the Eye. Chem Immunol Allergy 922007

Author(s)

Total Pages

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[Book] Acute retinal necrosis(92, Review)2007

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[Journal Article] 【視神経症と自己抗体との関連】 抗MOG抗体 眼科の立場から2017

Author(s)

Journal Title

Data Source

[Journal Article] 視神経炎．特集/眼科における薬物療法パーフェクトガイド．2017

Kezuka Takeshi 毛塚剛司

KEZUKA Takeshi 毛塚剛司

毛塚剛司ケヅカタケシ

[Journal Article] 【視神経症と自己抗体との関連】抗MOG抗体　眼科の立場から2017

[Journal Article] 【視神経炎と視神経症:全身と眼の架け橋】眼科臨床における視神経炎と視神経症の位置づけ2016

[Journal Article] 抗アクアポリン4抗体陽性視神経炎．　特集 / 視神経炎のよりよい治療2014

[Journal Article] 視神経脊髄炎　神経眼科における免疫学的進歩2014

[Journal Article] 視神経炎をみたら．特集: 神経眼科Minimum Requirements.2013

[Journal Article] 第116回　日本眼科学会総会　評議員会指名講演III　神経眼科の進歩　視神経炎　―免疫学的アプローチによる病態の解明と新規治療法の開発－2013