YOSHIDA Takuya 吉田卓也

… Alternative Names

Yoshida Takuya 吉田卓也

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Researcher Number	00294116
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院薬学研究科, 准教授 2021 – 2023: 大阪大学, 大学院薬学研究科, 准教授 2017 – 2021: 大阪大学, 薬学研究科, 准教授 2007 – 2009: Osaka University, 薬学研究科, 助教 2008: 大阪大学, 薬学部, 助教 … More 2002 – 2006: 大阪大学, 薬学研究科, 助手 2005: Osaka University, Graduate School of Pharmaceutical Sciences, Research Associate, 大学院・薬学研究科, 助手 1998 – 2000: 大阪大学, 薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Physical pharmacy / Physical pharmacy / 医薬分子機能学 / Biophysics / Biological Sciences
Keywords	Principal Investigator NMR / 立体構造 / 創薬 / RAGE / AGE / 構造生物学 / 結晶構造 / MD / X線結晶構造解析 / 結晶化 … More / MDシミュレーション / コラーゲン / LAIR / RXRα / PPARγ / 転写共役因子 / RXR / PPAR / 核内受容体 / 動的構造 / タンパク質 / ダイナミクス / RRF / リボソーム … More Except Principal Investigator NMR / PPAR / 核内受容体 / RRF / 立体構造解析 / BMP / 分子間相互作用 / 立体構造 / 水和 / トリプルヘリックス構造 / 脂質代謝 / 早期診断技術 / 薬物送達技術 / タイトジャンクション / 血液脳関門 / 認知症 / 分子病態学 / リガンド / PGAM5 / LPIN / 分子代謝学 / NASH / hydration / partial molar volume / entropy / enthalpy / 4-fluoroproline / 4-hydroxyproline / triple helical structure / collagen model peptides / トリプルヘリックス / コラーゲンモデルペブチド / フルオロプロリン / ヒドロキシプロリン / 部分モル体積 / エントロピー / エンタルピー / 4-フルオロプロリン / 4-ヒドロキシプロリン / コラーゲンモデルペプチド / Drug design / Antibiotics / Interaction / Ribosome / ドラッグデザイン / 抗菌剤 / 相互作用 / リボソーム / structure / receptor / 複合体 / レセプター / intrinsic compriessibility / intrinsic volume / volumetric study / thermodynamics / Protein-Ligand intenaction / 偏比容 / 示差熱測定 / 蛋白質-蛋白質の相互作用 / 密度測定 / 熱分析 / 蛋白質-リガンド相互作用 / 構造機能相関 / 触媒機構 / 炭酸脱水酵素 / MM / QM / プロトン移動 / 反応機構 / 触媒 / 互変異性 / ヒスチジン / 機能 / 酵素 / タンパク質 / 超分子 / 熱安定性 / 解離会合平衡 / コラーゲン様ドメイン / 多量体形成 / アディポネクチン Less

構造生物学的手法を用いたNR4およびNR6の創薬標的化Principal Investigator
- Principal Investigator
  
  吉田卓也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  The University of Osaka
Building the foundation for preventive medical strategies against dementia to realize a sustainable super-aging society
- Principal Investigator
  
  TACHIBANA Keisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Integrated structural analyses of LAIRPrincipal Investigator
- Principal Investigator
  
  Yoshida Takuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Osaka University
Development of NASH therapeutics by regulating energy expenditure and inflammation through the lipid sensor PPAR
- Principal Investigator
  
  Keisuke TACHIBANA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Structural Basis for Nuclear Receptor Dimer Activation Based on Multi-Molecular Interaction AnalysisPrincipal Investigator
- Principal Investigator
  
  Yoshida Takuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
AGE-RAGE interaction as a target for drug design against diabetes complicationsPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Takuya
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
NMR and MM Analysis of Tautomerization of His64 Coupled to Ionization of Zinc-bound Solvent during Proton Transfer in Carbonic Anhydrase
- Principal Investigator
  
  SHIMAHARA Hideto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Japan Advanced Institute of Science and Technology
終末糖化産物AGEレセプターの機能構造解析と創薬への応用Principal Investigator
- Principal Investigator
  
  吉田卓也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
アディポネクチンの超分子構造・相互作用解析
- Principal Investigator
  
  KOBAYASHI Yuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University of Pharmaceutical Sciences
  Osaka University
Investigation of the Stabilizing Mechanism of Collagen
- Principal Investigator
  
  KOBAYASHI Yuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
  Osaka University
リボソーム複合体中でのタンパク質の動的構造解析Principal Investigator
- Principal Investigator
  
  吉田卓也
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
The development of NMR methods for drug discovery targeting on ribosome recycling.
- Principal Investigator
  
  KOBAYASHI Yuji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Structural analysis of BMP and BMP receptor
- Principal Investigator
  
  KOBAYASHI Yuji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
Thermodynamic Analysis of Protein-Ligand interactions
- Principal Investigator
  
  KOBAYASHI Yuji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University

All 2023 2022 2021 2020 2017 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme2022
- Author(s)
  Takahashi Hikaru、Hase Hiroaki、Yoshida Takuya、Tashiro Junki、Hirade Yoshihiro、Kitae Kaori、Tsujikawa Kazutake
- Journal Title
  
  Chemical Biology & Drug Design
  
  Volume: 100 Issue: 1 Pages: 1-12
- DOI
  10.1111/cbdd.14051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06999
[Journal Article] Structural basis for the toxin-coregulated pilus?dependent secretion of <i>Vibrio cholerae</i> colonization factor2022
- Author(s)
  Oki Hiroya、Kawahara Kazuki、Iimori Minato、Imoto Yuka、Nishiumi Haruka、Maruno Takahiro、Uchiyama Susumu、Muroga Yuki、Yoshida Akihiro、Yoshida Takuya、Ohkubo Tadayasu、Matsuda Shigeaki、Iida Tetsuya、Nakamura Shota
- Journal Title
  
  Science Advances
  
  Volume: 8 Issue: 41 Pages: 1-11
- DOI
  10.1126/sciadv.abo3013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07024, KAKENHI-PROJECT-20KK0183, KAKENHI-PROJECT-20K06999, KAKENHI-PROJECT-20K07478, KAKENHI-PROJECT-20K16245
[Journal Article] Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.2020
- Author(s)
  Yoshida T, Oki H, Doi M, Fukuda S, Yuzuriha T, Tabata R, Ishimoto K, Kawahara K, Ohkubo T, Miyachi H, Doi T, Tachibana K.
- Journal Title
  
  Scientific Reports
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03190
[Journal Article] Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives2020
- Author(s)
  Yoshida Takuya、Oki Hiroya、Doi Michihiro、Fukuda Syohei、Yuzuriha Tomohiro、Tabata Ryotaro、Ishimoto Kenji、Kawahara Kazuki、Ohkubo Tadayasu、Miyachi Hiroyuki、Doi Takefumi、Tachibana Keisuke
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 7623-7623
- DOI
  10.1038/s41598-020-64527-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08236
[Journal Article] Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase2010
- Author(s)
  Takahashi R, Nakamura S, Nakazawa T, Minoura K, Yoshida T, Nishi Y, Kobayashi Y, Ohkubo T.
- Journal Title
  
  J Biochem. 147
  
  Pages: 95-107
- NAID
  10027873352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790034
[Journal Article] Tautomerism of histidine 64 associated with proton transfer in catalysis of Carbonic Anhydrase2008
- Author(s)
  島原秀登, 吉田卓也, 水上卓, 中沢隆, 長尾秀実, 大久保忠恭, 小林祐次, (他2名, 1番目)
- Journal Title
  
  FASEB Journal 22巻
- Data Source
  KAKENHI-PROJECT-19770128
[Journal Article] Solution structure of the variable-type domain of the receptor for advanced glycation end products: new insight into AGE-RAGE interaction.2008
- Author(s)
  Matsumoto S, Yoshida T, Murata H, Harada S, Fujita N, Nakamura S, Yamamoto Y, Watanabe T, Yonekura H, Yamamoto H, Ohkubo T, Kobayashi Y.
- Journal Title
  
  Biochemistry 47
  
  Pages: 12299-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790034
[Journal Article] Tautomerism of histidine 64 associated with proton-transfer in catalysis of carbonic anhydrase2007
- Author(s)
  島原秀登, 吉田卓也, 中沢隆, 大久保忠恭, 小林祐次, (他10名,1番目)
- Journal Title
  
  J Biol Chem 282巻
  
  Pages: 9646-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770128
[Patent] ＰＰＡＲα転写活性化剤およびその医薬用途2021
- Inventor(s)
  土井健史,橘敬祐,赤井周司,吉田卓也,森江俊哉,辻川和丈ら
- Industrial Property Rights Holder
  土井健史,橘敬祐,赤井周司,吉田卓也,森江俊哉,辻川和丈ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-095378
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] 核内受容体PPARγのリガンド結合における動的構造の役割2023
- Author(s)
  田井中康平, 吉田卓也 , 岩本梨奈, 花岡智仁, 河原一樹, 大久保忠恭
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K06999
[Presentation] NMRによる核内受容体PPARγ/RXRαヘテロダイマーの相互作用解析2020
- Author(s)
  坂口俊介、吉田卓也、河原一樹、大久保忠恭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08236
[Presentation] NMRで見るタンパク質の過渡的な複合体形成2017
- Author(s)
  吉田卓也
- Organizer
  平成29年度日本分光学会NMR分光部会講習会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08236
[Presentation] 立体構造に基づく終末糖化産物AGE受容体とリガンド間の相互作用解析2010
- Author(s)
  藤田直子, 吉田卓也, 他
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山市
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20790034
[Presentation] 非線形サンプリングデータ解析法の改良2009
- Author(s)
  吉田卓也, 他
- Organizer
  NMR討論会
- Place of Presentation
  福岡市
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-20790034
[Presentation] 非線形サンプリングデータ解析法の改良2009
- Author(s)
  吉田卓也
- Organizer
  NMR討論会
- Place of Presentation
  九州大学(福岡県)
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-20790034
[Presentation] AGEレセプター阻害化合物の探索と評価2008
- Author(s)
  原田秀作, 吉田卓也, 他
- Organizer
  第55回日本生化学会近畿支部例会
- Place of Presentation
  大阪市
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-20790034
[Presentation] NMR Approach to His-64 Involved in Proton-Transfer Mechanism in Catalysis of Carbonic Anhydrase2007
- Author(s)
  島原秀登, Shimahara, H., Yoshida, T., Nakazawa, T., Ohkubo, T., & Kobayashi, Y.
- Organizer
  12th European Conference on the Spectroscopy of Biological Molecules
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-19770128

1. KOBAYASHI Yuji (20127228)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
2. OHKUBO Tadayasu (90272997)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. Keisuke TACHIBANA (30432446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 石本憲司 (00572984)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. SHIMAHARA Hideto (40313704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. NAKAZAWA Takashi (30175492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. SAKIYAMA Fumio (40029947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAGAO Hidemi (30291892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MIZUKAMI Taku (50270955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. TOMIYAMA Tetsuo (20155576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHI Yoshinori (70397727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 土井健史 (00211409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 樋野展正 (90469916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUGIMORI Kimikazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAJIYAMA Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KAWAHARA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIDA Takuya 吉田 卓也

Yoshida Takuya 吉田 卓也

Research Projects

Research Products

Co-Researchers

構造生物学的手法を用いたNR4およびNR6の創薬標的化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Review Section

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Integrated structural analyses of LAIRPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural Basis for Nuclear Receptor Dimer Activation Based on Multi-Molecular Interaction AnalysisPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

AGE-RAGE interaction as a target for drug design against diabetes complicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

終末糖化産物AGEレセプターの機能構造解析と創薬への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Principal Investigator

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リボソーム複合体中でのタンパク質の動的構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Principal Investigator

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YOSHIDA Takuya 吉田卓也

Yoshida Takuya 吉田卓也