Chiba Hideki 千葉英樹

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CHIBA Hideki 千葉英樹

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Researcher Number	00295346
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 福島県立医科大学, 医学部, 教授 2014 – 2015: 福島県立医科大学, 医学部, 教授 2011 – 2012: 福島県立医科大学, 医学部, 教授 2007 – 2009: Sapporo Medical University, School of Medicine, Associate Professor 2006: Sapporo Medical University, School of Medicine, Associate Professor, 医学部, 助教授 2000 – 2005: 札幌医科大学, 医学部, 講師 1998 – 1999: 札幌医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Human pathology / Basic Section 49030:Experimental pathology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Basic Section 49020:Human pathology-related / Experimental pathology / Obstetrics and gynecology / Obstetrics and gynecology / Experimental pathology … More / Human pathology / Tumor biology / Human pathology / Ophthalmology Less
Keywords	Principal Investigator タイト結合 / 核内受容体 / クローディン / がん / 細胞接着 / HNF-4α / 血液組織関門 / 細胞間接着 / 細胞間接着装置 / 細胞極性 … More / 病理学 / ノックアウト細胞 / 遺伝子発現誘導 / Cre / F9 / レチノイド / 代謝 / 浸潤 / がん悪性形質 / がん増悪 / 腫瘍 / バイオマーカー / 増悪 / リン酸化 / 組織再生 / 皮膚損傷 / ニッチ / 脂肪由来幹細胞 / 間葉系幹細胞 / 幹細胞 / 細胞内シグナル / クロストーク / 子宮内膜癌 / 子宮体がん / 子宮体癌 / シグナル伝達 / エストロゲン受容体 / blood-tissue barrier / tight junction / junctional complex / cell proliferation / epithelial differentiation / epithelial polarization / nuclear receptor / プロテインキナーゼC / 細胞増殖 / 上皮分化 / Enodothelial cells / Protein kinase A / Cyclic AMP / MAP kinase / Blood-tissue barrier / Blood-brain barrier / Claudin / Tight junction / Tet-onシステム / 血管内皮細胞 / プロテインキナーゼA / サイクリックAMP / MAPキナーゼ / 血液脳関門 / 分化転換 / 再生医学 / C型肝炎 / トランスレーショナルリサーチ / C型肝炎ウィルス / 抗体医薬 / トうンスレーショナルリサーチ / 肝癌 / 感染症 / C 型肝炎ウィルス / 細胞・組織 / クローデイン / loxP / 遺伝子発現誘導システム / 部位特異的遺伝子組換え / リガンド誘導性Creリコンビナーゼ / lox P / 生体バリアー / 臓器内胚芽 / 上皮 … More Except Principal Investigator タイト結合 / occludin / claudin-5 / tight junction / claudin / クローディン / HNF-4α / Fas Ligand / insulin resistance / adiponectin / matrix metalloproteinase / vascular endothelial growth factor / Toll-like receptor / TSLP / ヒト鼻粘膜 / 病理学 / 鼻アレルギー / Ca吸収 / 糖尿病網膜症 / バリア機能 / 血管内皮細胞 / 腸管オルガノイド / ゲノム編集 / 腸上皮幹細胞 / 蠕動 / JAMファミリー / CLMP / 腸管幹細胞 / Ca absorption / diabetic retinopathv / glial cell / retinoic acid / human nasal mucosa / 上皮細胞極性 / フェンス機能 / シグナル伝達 / アポトーシス / オクルジン / グリア細胞 / レチノイン酸 / follicle atresia / polycystic ovary / androgen / HOMA / BMI / testosteorone / polysyctic ovary syndrome / MT1-MMP / caspase 8 / Fas / apoptosis / testosterone / polycystic ovary syndrome / 閉鎖卵胞 / 多嚢胞卵巣 / fa)ラット / Zucker (fa / FasLligand / 卵胞閉鎖 / 多嚢胞性卵巣 / インスリン抵抗性 / アンドロゲン / vascular permeability / ovarian hyperstimulation syndrome / corous Luteum / 血管新生 / 血管透過性 / 卵巣過剰刺激症候群 / 黄体 / gap junction / nuclear receptor / hepatocyte / enodothelial cells / PI3K / MAPK / ギャップ結合 / 核内レセプター型転写因子 / 肝細胞 / differentiation / smooth-msucle actin / osteoblast / pericyte / 分化機能 / 平滑筋アクチン / 骨芽細胞 / 血管周皮細胞 / ペリサイト / 予後因子 / 転移 / がん転移 / 細胞運動 / 浸潤 / 予後 / 乳癌 / S100A16 / S100A14 / ビタミンD受容体欠損マウス / Ca吸収機構 / 樹状細胞 / 生体機能利用 / 細胞・組織 / サイトカイン / 肝(黄疸) / 膵管上皮 / TER / 血液透過性 / neurturin / GDNF / 血液脳関門 / 血液網膜関門 / アクチン / Min mouse / 細胞電気抵抗 Less

Novel mechanism of cancer progression by phosphorylation of nuclear receptorsPrincipal Investigator
- Principal Investigator
  
  千葉英樹
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Fukushima Medical University
Tissue regeneration using the niche signal for stem cellsPrincipal Investigator
- Principal Investigator
  
  Chiba Hideki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Fukushima Medical University
Fate decision of intestinal stem cells by tight junction molecules
- Principal Investigator
  
  Tanaka Mizuko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Fukushima Medical University
Promotion of cancer progression by aberrant cell adhesion signalingPrincipal Investigator
- Principal Investigator
  
  Chiba Hideki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Fukushima Medical University
Development of a novel direct reprogramming method using cell adhesion signalPrincipal Investigator
- Principal Investigator
  
  Chiba Hideki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Fukushima Medical University
Analysis of molecular function of S100A14 and its clinical aplication to diagnosis and therapy of breast cancer.
- Principal Investigator
  
  SUGINO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of a novel therapy targeting tight-junction protein occludin against hepatitis CPrincipal Investigator
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Fukushima Medical University
Pathobiology of the tight junction : from cell biology of paracellular pathway to bed-side
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Regulation of biological barrier and cell polarity formationPrincipal Investigator
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Biological barrier and human diseases
- Principal Investigator
  
  KOJIMA Takashi, 小山内誠
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Molecular mechanism of formation and regulation of the biological barrierPrincipal Investigator
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Study for the etiology of polycystic ovary using a rat model
- Principal Investigator
  
  ENDO Toshiaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Sapporo Medical University
Molecular pathophysiology of the biological barrier regulation of molecular passage through paracellular spaces.
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Reconstitution and regulation of the blood-tissue barrierPrincipal Investigator
- Principal Investigator
  
  CHIBA Hideki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
The differences of mechanisms between normal luteal formation and occurrence of ovarian hyperstimulation syndrome
- Principal Investigator
  
  ENDO Toshiaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Sapporo Medical University
遺伝子改変F9細胞株を用いた生体バリアの機能解析Principal Investigator
- Principal Investigator
  
  千葉英樹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
糖尿病網膜症と血液網膜関門のタイト結合
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Sapporo Medical University
Induction of pericyte differentiation in human osteoblastic cell line
- Principal Investigator
  
  IKEDA Tatsuru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
血管内皮細胞のタイト結合蛋白と癌転移
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Sapporo Medical University
生体バリアー関連分子の同定と機能解析に関する研究Principal Investigator
- Principal Investigator
  
  千葉英樹
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University

[Journal Article] Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma2025
- Author(s)
  Mine Hayato、Sugimoto Kotaro、Kobayashi Makoto、Takagi Hironori、Okabe Naoyuki、Muto Satoshi、Kobayashi Yasuyuki、Hashimoto Yuko、Suzuki Hiroyuki、Chiba Hideki
- Journal Title
  
  BMC Cancer
  
  Volume: 25 Issue: 1 Pages: 764-764
- DOI
  10.1186/s12885-025-14160-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27394
[Journal Article] がんの発生進展とクローディン2024
- Author(s)
  杉本幸太郎, 千葉英樹
- Journal Title
  
  癌と化学療法
  
  Volume: 51 Pages: 1105-1110
- Data Source
  KAKENHI-PROJECT-23K27394
[Journal Article] Extrajunctional CLDN10 cooperates with LAT1 and accelerates clear cell renal cell carcinoma progression2024
- Author(s)
  Onagi Akifumi、Sugimoto Kotaro、Kobayashi Makoto、Sato Yumi、Kobayashi Yasuyuki、Yaginuma Kei、Meguro Satoru、Hoshi Seiji、Hata Jyunya、Hashimoto Yuko、Kojima Yoshiyuki、Chiba Hideki
- Journal Title
  
  Cell Communication and Signaling
  
  Volume: 22 Issue: 1 Pages: 588-588
- DOI
  10.1186/s12964-024-01964-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15534, KAKENHI-PROJECT-23K27394
[Journal Article] Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence2023
- Author(s)
  Nishimagi Atsushi、Kobayashi Makoto、Sugimoto Kotaro、Kofunato Yasuhide、Sato Naoya、Haga Junichiro、Ishigame Teruhide、Kimura Takashi、Kenjo Akira、Kobayashi Yasuyuki、Hashimoto Yuko、Marubashi Shigeru、Chiba Hideki
- Journal Title
  
  Clinical and Experimental Medicine
  
  Volume: 23 Issue: 8 Pages: 4985-4995
- DOI
  10.1007/s10238-023-01098-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08896, KAKENHI-PROJECT-23K08716, KAKENHI-PROJECT-21K06950, KAKENHI-PROJECT-23K27394
[Journal Article] Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β2023
- Author(s)
  Murakami-Nishimagi Yuko、Sugimoto Kotaro、Kobayashi Makoto、Tachibana Kazunoshin、Kojima Manabu、Okano Maiko、Hashimoto Yuko、Saji Shigehira、Ohtake Tohru、Chiba Hideki
- Journal Title
  
  Breast Cancer Research
  
  Volume: 25 Issue: 1 Pages: 41-41
- DOI
  10.1186/s13058-023-01646-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08716, KAKENHI-PROJECT-21K06950, KAKENHI-PROJECT-23K27394
[Journal Article] Soluble JAM-C Ectodomain Serves as the Niche for Adipose-Derived Stromal/Stem Cells2021
- Author(s)
  Yamazaki Morio、Sugimoto Kotaro、Mabuchi Yo、Yamashita Rina、Ichikawa-Tomikawa Naoki、Kaneko Tetsuharu、Akazawa Chihiro、Hasegawa Hiroshi、Imura Tetsuya、Chiba Hideki
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 3 Pages: 278-278
- DOI
  10.3390/biomedicines9030278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01753, KAKENHI-PROJECT-19KK0216, KAKENHI-PROJECT-21H03328, KAKENHI-PROJECT-19K10024, KAKENHI-PROJECT-20K21529, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-19K16615
[Journal Article] Molecular organization, regulation and function of tricellular junctions2020
- Author(s)
  Higashi Tomohito、Chiba Hideki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1862 Issue: 2 Pages: 183143-183143
- DOI
  10.1016/j.bbamem.2019.183143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08699, KAKENHI-PROJECT-18K06223
[Journal Article] Cell adhesion signals regulate the nuclear receptor activity2019
- Author(s)
  Sugimoto Kotaro、Ichikawa-Tomikawa Naoki、Kashiwagi Korehito、Endo Chihiro、Tanaka Satoshi、Sawada Norimasa、Watabe Tetsuya、Higashi Tomohito、Chiba Hideki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 49 Pages: 24600-24609
- DOI
  10.1073/pnas.1913346116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08699, KAKENHI-PROJECT-17K08766, KAKENHI-PROJECT-19K16615
[Journal Article] Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth2015
- Author(s)
  Morhayim J, van de Peppel J, Demmers JA, Kocer G, Nigg AL, van Driel M, Chiba H, van Leeuwen JP
- Journal Title
  
  FASEB J
  
  Volume: 29 Issue: 1 Pages: 274-285
- DOI
  10.1096/fj.14-261404
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670191
[Journal Article] The liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression2015
- Author(s)
  Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H
- Journal Title
  
  Oncotarget
  
  Volume: 6 Issue: 32 Pages: 33345-33357
- DOI
  10.18632/oncotarget.5428
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670191
[Journal Article] Methionine aminopeptidase 2 as a potential therapeutic target for human non-small cell lung cancers2015
- Author(s)
  Shimizu H, Yamagishi S, Chiba H, Ghazizadeh M
- Journal Title
  
  Adv Clin Exp Med
  
  Volume: 25 Pages: 117-128
- Data Source
  KAKENHI-PROJECT-26670191
[Journal Article] Expression and function of lysophosphatidic acid receptor 1 in bladder cancer2015
- Author(s)
  Kataoka M, Ishibashi K, Kumagai S, Yanagida T, Aikawa K, Chiba H, Kojima Y
- Journal Title
  
  J Urol
  
  Volume: 194 Issue: 1 Pages: 238-244
- DOI
  10.1016/j.juro.2014.12.028
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670191
[Journal Article] Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion.2015
- Author(s)
  Tanaka M, Ichikawa-Tomikawa N, Shishito N, Nishiura K, Miura T, Hozumi A, Chiba H, Yoshida S, Ohtake T, Sugino T
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Issue: 1 Pages: 53-53
- DOI
  10.1186/s12885-015-1059-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-26670191
[Journal Article] Evidence of vitamin D and interferon-ss cross-talk in human osteoblasts with 1a ,25-dihydroxyvitamin D_3 and rosigliatazone synergistically osteoblast-mediated mineralization.2013
- Author(s)
  Woeckel VJ, Bruedigam C, Koedam M, Chiba H, van der Eerden BC, van LeeuwenJP
- Journal Title
  
  Gene
  
  Volume: 512 Pages: 438-443
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] 蛍光ダイレクトラベリングによる生細胞蛍光イメージング2012
- Author(s)
  冨川(市川)直樹, 千葉英樹
- Journal Title
  
  Surgery Frontier
  
  Volume: 19 Pages: 335-340
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] IFN ss impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation2012
- Author(s)
  Woeckel VJ, Eijken M, van de Peppel J, Chiba H, van der Eerden BC, van LeeuwenJP
- Journal Title
  
  J Cell Physiol
  
  Volume: 227 Pages: 2668-2676
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Stereotaxic injection の手法と応用2012
- Author(s)
  冨川(市川)直樹, 千葉英樹
- Journal Title
  
  Surgery Frontier
  
  Volume: 19 Pages: 445-450
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Evidence of vitamin D and interferon- ss cross-talk in human osteoblasts with 1a,25-dihydroxyvitamin D_3 being dominant over interferon-ss in stimulating mineralization2012
- Author(s)
  Woeckel VJ, Eijken M, van de Peppel J, Chiba H, van der Eerden BC, van LeeuwenJP
- Journal Title
  
  J Cell Physiol
  
  Volume: 227 Pages: 3258-3266
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] The transient potential channel TRPV6 is dynamically expressed in bone cells but in not crucial for bone mineralization in mice2012
- Author(s)
  van der Eerden BC, Weissgerber P, Fratzl-Zelman N, Olausson J, Hoenderop JG,Schreuders-Koedam M, Eijken M, Roschger P, de Vries TJ, Chiba H, Klaushofer K, Flockerzi V, Bindels RJ, Freichel M, van Leeuwen JP
- Journal Title
  
  J Cell Physiol
  
  Volume: 227 Pages: 1951-1959
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Laminin a1 is essential for mouse cerebellar development.2012
- Author(s)
  Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y,Arikawa-Hirasawa E
- Journal Title
  
  Matrix Biol
  
  Volume: 31 Pages: 17-28
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Claudin-4-targeted therapy using Clostridium Perfringensenterotoxin for prostate cancer2012
- Author(s)
  Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N
- Journal Title
  
  Prostate
  
  Volume: 72 Pages: 351-360
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Interphase cytogenetic analysis of lung adenocarcinomas with bronchioloalveolar pattern.2012
- Author(s)
  Shimizu H, Sugino T, Chiba H.
- Journal Title
  
  Fukushima J Med Sci.
  
  Volume: 58(1) Pages: 66-73
- NAID
  130002153561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501318
[Journal Article] Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells2011
- Author(s)
  Bruedigam C, Eijken M, Koedam M, Chiba H, van Leeuwen JP
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 51 Pages: 862-871
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Possible involevement of tight junctions, extracellular matrix and nuclear receptors in epithelial differentiation2011
- Author(s)
  Ichikawa-Tomikawa N, Sugimoto K, Satohisa S, Nishiura K, Chiba H
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Pages: 253048-253048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Possible involevement of tight junctions, extracellular matrix and nuclear receptors in epithelialdifferentiation2011
- Author(s)
  Ichikawa-Tomikawa N, Sugimoto K, Satohisa S, Nishiura K, Chiba H
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Pages: 253048-253048
- Data Source
  KAKENHI-PROJECT-23659187
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes.2009
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 1463-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Thymic stromal lymphopoietin enhances tight junction barrier function of human nasal epithelial cells.2009
- Author(s)
  Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 338
  
  Pages: 283-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, Osanai M, Murata M, Kojima T, Sawada N
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy2008
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Inatomi S, Ohguro H, Sawada N
- Journal Title
  
  Clinical Ophthalmology 2
  
  Pages: 233-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone : Fine-tuning by hormonal regulation and mRNA stability2008
- Author(s)
  Bruedigam C, Koedam M, Chiba H, Eijken M, van Leeuwen JP
- Journal Title
  
  FEBS Lett 582
  
  Pages: 1618-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner2008
- Author(s)
  Eijken M, Meijer IM, Westbroek I, Koedam M, Chiba H, Uitterlinden AG, Pols HA, van Leeuwen JP
- Journal Title
  
  J Cell Biochem 104
  
  Pages: 568-579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Transmembrane proteins of tight junctions2008
- Author(s)
  Chiba H, et. al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway2008
- Author(s)
  Hatakeyama N, Kojima T, Iba K, Murata M, Thi MM, Spray DC, Osanai M, Chiba H, Ishii S, Yamashita T, Sawada N
- Journal Title
  
  Cell Tissue Res 334
  
  Pages: 243-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma2008
- Author(s)
  Satake S, Semba S, Matsuda Y, Usami Y, Chiba H, Sawada N, Kasuga M, Yokozaki H
- Journal Title
  
  Pathol Int 58
  
  Pages: 156-163
- NAID
  10027375982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Tight junction proteins claudin-2 and-12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.2008
- Author(s)
  Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H
- Journal Title
  
  Mol Biol Cell 19
  
  Pages: 1912-1921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, et. al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, et. al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transmembrane proteins of tight junctions2008
- Author(s)
  Chiba H, Osanai M, Murata M, Kojima T, Sawada N
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, et. al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba, H, et. al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma.2008
- Author(s)
  Satake S, Semba S, Matsuda Y, Usami Y, Chiba H, Sawada N, Kasuga M, Yokozaki H
- Journal Title
  
  Pathol Int 58
  
  Pages: 156-163
- NAID
  10027375982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation2008
- Author(s)
  Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Mol Pharmacol 74
  
  Pages: 432-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, et al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Transmembrane proteins of tight junctions.2008
- Author(s)
  Chiba H, et al.
- Journal Title
  
  BBA-Biomembranes 1778
  
  Pages: 588-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway.2008
- Author(s)
  Hatakeyama N, Kojima T, Iba K, Murata M, Thi MM, Spray DC, Osanai M, Chiba H, Ishii S, Yamashita T, Sawada N
- Journal Title
  
  Cell Tissue Res 334
  
  Pages: 243-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transforming growth factor-β induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes2008
- Author(s)
  Kojima T, Takano K, Yamamoto T, Imamura M, Murata M, Son S, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Liver Int 28
  
  Pages: 534-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy.2008
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Inatomi S, Ohguro H, Sawada N
- Journal Title
  
  Clinical Ophthalmology 2
  
  Pages: 233-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma2008
- Author(s)
  Nakayama F, Semba S, Usami Y, Chiba H, Sawada N, Yokozaki H
- Journal Title
  
  Pathobiology 75
  
  Pages: 177-185
- NAID
  120001408357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008
- Author(s)
  Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Mol Pharmacol 74
  
  Pages: 432-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Transforming growth factor-βinduces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes.2008
- Author(s)
  Kojima T, Takano K, Yamamoto T, Imamura M, Murata M, Son S, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Liver Int 28
  
  Pages: 534-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.2008
- Author(s)
  Nakayama F, Semba S, Usami Y, Chiba H, Sawada N, Yokozaki H
- Journal Title
  
  Pathobiology 75
  
  Pages: 177-185
- NAID
  120001408357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca^<2+> absorption between enterocytes2008
- Author(s)
  Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H
- Journal Title
  
  Mol Biol Cell 19
  
  Pages: 1912-1921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Heterogeneous expression of claudin-4 in human colorectal cancer : decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis2007
- Author(s)
  Ueda J, Semba S, Chiba H, Sawada N, Seo Y, Kasuga M, Yokozaki H
- Journal Title
  
  Pathobiology 74
  
  Pages: 32-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Ohguro H, Sawada N
- Journal Title
  
  Invest Ophthalmol Vis Sci 48
  
  Pages: 2224-2229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells.2007
- Author(s)
  Osanai M, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1557-1562
- NAID
  10019997370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions.2007
- Author(s)
  Imamura M, Kojima T, Lan M, Son S, Murata M, Osanai M, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 1951-1962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Gastric and intestinal claudin expression at the invasive front of gastric carcinoma.2007
- Author(s)
  Matsuda Y, Semba S, Ueda J, Fuku T, Hasuo T, Chiba H, Sawada N, Kuroda Y, Yokozaki H
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1014-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span2007
- Author(s)
  Kurose M, Kojima T, Koizumi J, Kamekura R, Ninomiya T, Murata M, Ichimiya S, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 330
  
  Pages: 63-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Gastric and intestinal claudins expression at the invasive front of gastric carcinoma2007
- Author(s)
  Matsuda Y, Semba S, Ueda J, Fuku T, Hasuo T, Chiba H, Sawada N, Kuroda Y, Yokozaki H
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1014-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system.2007
- Author(s)
  Koizumi J, Kojima T, Kamekura R, Kurose M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Membr Biol 218
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Cellular retinoic acid bioavailability determines epithelial integrity : role of retinoic acid receptor alpha agonists in colitis2007
- Author(s)
  Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells.2007
- Author(s)
  Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1027-1034
- NAID
  120002187916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Ohguro H, Sawada N
- Journal Title
  
  Invest Ophth Vis Sci 48
  
  Pages: 2224-2229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system2007
- Author(s)
  Koizumi J, Kojima T, Kamekura R, Kurose M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Membr Biol 218
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] nduction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span.2007
- Author(s)
  Kurose M, Kojima T, Koizumi J, Kamekura R, Ninomiya T, Murata M, Ichimiya S, Osanai M, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 330
  
  Pages: 63-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] A novel monoclonal antibody against second extracellular loop of occludin disrupts epithelial cell polarity2007
- Author(s)
  Tokunaga Y, Kojima T, Osanai M, Murata M, Chiba H, Tobioka H, Sawada N
- Journal Title
  
  J Histochem Cytochem 55
  
  Pages: 735-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression patterns of claudin family of tight-junction proteins in the mouse prostate.2007
- Author(s)
  Sakai N, Chiba H, Fujita H, Akashi Y, Osanai M, Kojima T, Sawada N
- Journal Title
  
  Histochem Cell Biol 127
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, Sawada N
- Journal Title
  
  Diabetes 56
  
  Pages: 1333-1340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis.2007
- Author(s)
  Ueda J, Semba S, Chiba H, Sawada N, Seo Y, Kasuga M, Yokozaki H
- Journal Title
  
  Pathobiology 74
  
  Pages: 32-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells2007
- Author(s)
  Osanai M, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1557-1562
- NAID
  10019997370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis.2007
- Author(s)
  Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy.2007
- Author(s)
  Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, Sawada N
- Journal Title
  
  Diabetes 56
  
  Pages: 1333-1340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] A novel monoclonal antibody against the second extracellular loop of occludin disrupts epithelial cell polarity.2007
- Author(s)
  Tokunaga Y, Kojima T, Osanai M, Murata M, Chiba H, Tobioka H, Sawada N
- Journal Title
  
  J Histochem Cytochem 55
  
  Pages: 735-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions2007
- Author(s)
  Imamura M, Kojima T, Lan M, Son S, Murata M, Osanai M, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 1951-1962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells2007
- Author(s)
  Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1027-1034
- NAID
  120002187916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] Expression patterns of claudin family of tight-junction proteins in the mouse prostate2007
- Author(s)
  Sakai N, Chiba H, Fujita H, Akashi Y, Osanai M, Kojima T, Sawada N
- Journal Title
  
  Histochem Cell Biol 127
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Journal Article] The significance of interferon-γ-triggered internalization of tight junction proteins in inflammatory bowel disease.2006
- Author(s)
  Chiba H et al.
- Journal Title
  
  Sci STKE 316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590322
[Journal Article] The nuclear receptor hepatocyte nuclear factor 4α acts as amorphogen to induce the formation of microvilli2006
- Author(s)
  Chiba H, et. al.
- Journal Title
  
  J Cell Biol 175
  
  Pages: 971-980
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] The significance of interferon-Y-triggered internalization of tight-junction proteins in inflammatory bowel disease.2006
- Author(s)
  Chiba, H, et. al.
- Journal Title
  
  Sci STKE 316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] The significance of interferon-y-triggered internalization of tight-junction proteins in inflammatory bowel disease.2006
- Author(s)
  Chiba H et al.
- Journal Title
  
  Sci STKE. 316
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] The nuclear receptor hepatocyte nuclear factor 4a acts as a morphogen to induce the formation of microvilli.2006
- Author(s)
  Chiba H et al.
- Journal Title
  
  J Cell Biol. 175
  
  Pages: 971-980
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] The significance of interferon-γ-triggered internalization of tight-junction proteins in inflammatory bowel disease.2006
- Author(s)
  Chiba H et al.
- Journal Title
  
  Sci STKE. 316
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] The significance of interferon-γ-triggered internalization of tight-junction proteins in inflammatory bowel disease.2006
- Author(s)
  Chiba H et al.
- Journal Title
  
  Sci STKE. 316
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590322
[Journal Article] The nuclear receptor hepatocyte nuclear factor 4o ; acts as a morphogen to induce the formation of microvilli.2006
- Author(s)
  Chiba, H, et. al.
- Journal Title
  
  J Cell Biol 175
  
  Pages: 971-980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Activation of p21^<CIP1/WAF1> gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α.2005
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res 302
  
  Pages: 11-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590322
[Journal Article] Activation of p21CIP1/WAF1 gene and inhibition of cell proliferation by hepatocyte nuclear factor-4α.2005
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res. 302
  
  Pages: 11-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] Activation of p21^<CIPI/WAFI> gene and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α2005
- Author(s)
  Chiba H, et. al.
- Journal Title
  
  Exp Cell Res. 302
  
  Pages: 11-21
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Activation of p21^<CIP1/WAF1> gene and inhibition of cell proliferation by overexpression of hepatocyte unclear factore-4α.2005
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res. 302
  
  Pages: 11-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590322
[Journal Article] Activation of p21^<CIP1/WAF1> gene and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α.2005
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res. 302
  
  Pages: 11-21
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Activation of p21^<CIPI/WAFI> gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4a.2005
- Author(s)
  Chiba, H, et. al.
- Journal Title
  
  Exp Cell Res 302
  
  Pages: 11-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390117
[Journal Article] Activation of p21^<CIP1/WAF1> gene and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α.2005
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res. 302
  
  Pages: 11-21
- Data Source
  KAKENHI-PROJECT-16590322
[Journal Article] Activation of p21^<CIP1/WAF1> gene and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4a2005
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res 302
  
  Pages: 11-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] 血液組織関門の形成と制御の分子機構2004
- Author(s)
  千葉英樹他
- Journal Title
  
  福岡医学雑誌 95
  
  Pages: 139-145
- NAID
  120002834501
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] 血液組織関門の形成と制御の分子機構2004
- Author(s)
  千葉英樹他
- Journal Title
  
  福岡医学雑誌 95
  
  Pages: 139-145
- NAID
  120002834501
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590322
[Journal Article] Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morpgology in F9 embryonal carcinoma cells.2003
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res. 286
  
  Pages: 288-297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells2003
- Author(s)
  Chiba H et al.
- Journal Title
  
  Exp Cell Res 286
  
  Pages: 288-297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370080
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590398
[Patent] がんのバイオマーカー、それに対する抗体、抗体を用いたがん患者の予後の予測方法、および、がんの検出方法2024
- Inventor(s)
  千葉英樹, 杉本幸太郎, 小林信
- Industrial Property Rights Holder
  千葉英樹, 杉本幸太郎, 小林信
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-077780
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23K27394
[Patent] がんのバイオマーカー及び抗体治療2024
- Inventor(s)
  千葉英樹, 杉本幸太郎, 小林信
- Industrial Property Rights Holder
  千葉英樹, 杉本幸太郎, 小林信
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27394
[Patent] 細胞培養補助剤2021
- Inventor(s)
  千葉英樹、杉本幸太郎
- Industrial Property Rights Holder
  千葉英樹、杉本幸太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K21529
[Patent] 子宮体癌患者の予後予測バイオマーカー2019
- Inventor(s)
  千葉英樹，杉本幸太郎
- Industrial Property Rights Holder
  千葉英樹，杉本幸太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08699
[Patent] 子宮体癌患者の予後予測マーカー2019
- Inventor(s)
  千葉英樹, 杉本幸太郎
- Industrial Property Rights Holder
  千葉英樹, 杉本幸太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] 核内受容体のリン酸化によるがん悪性形質促進機構2024
- Author(s)
  千葉英樹
- Organizer
  第113回日本病理学総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27394
[Presentation] CLDN4-LXR 連関による乳癌の悪性形質制御機構2023
- Author(s)
  杉本幸太郎、西間木 (村上)祐子、小林信、千葉英樹
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K27394
[Presentation] 肝受容体ホモログ -1 の異常セリンリン酸化は膵癌・肝癌の予後不良因子である2023
- Author(s)
  小林信、杉本幸太郎、西間木淳、小林靖幸、千葉英樹
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K27394
[Presentation] ラットモノクローナル抗体の樹立と有用性2020
- Author(s)
  千葉英樹
- Organizer
  第5回DSANJ Bio Conference'20 Open
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] 幹細胞培養補助剤：JAM-C部分ペプチドは間葉系幹細胞の培養補助剤として有用である2019
- Author(s)
  千葉英樹, 杉本幸太郎
- Organizer
  ファーマラボEXPO
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] 子宮体癌患者の予後予測バイオマーカー2019
- Author(s)
  千葉英樹, 杉本幸太郎
- Organizer
  ファーマラボEXPO
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] ラットモノクローナル抗体の樹立と有用性－子宮体癌予後予測と悪性中皮腫の新規マーカーを例に2019
- Author(s)
  千葉英樹
- Organizer
  新技術説明会
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] タイト結合分子クローディンに対するモノクローナル抗体の樹立とその応用2019
- Author(s)
  杉本幸太郎、東淳子、東智仁、千葉英樹
- Organizer
  第108回日本病理学会
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] 細胞接着シグナルによる正常細胞機能とがん悪性形質の新規制御機構2018
- Author(s)
  杉本幸太郎，冨川直樹，柏木惟人，小島学，村上祐子，田中瑞子，東智仁，千葉英樹
- Organizer
  第107回日本病理学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] Mutual activation of Claudin-6 and Src family kinases triggers epithelial differentiation via RARγ phosphorylation2018
- Author(s)
  Kotaro Sugimoto, Naoki Ichikawa-Tomikawa, Korehito Kashiwagi, Tomohito Higashi, Hideki Chiba
- Organizer
  Joint Annual Meeting of JSDB 5st and JSCB 70th
- Invited
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] タイト結合分子クローディン-6の発現は子宮内膜癌の予後不良因子である2017
- Author(s)
  小島学、杉本幸太郎、田中瑞子、柏木維人、齋藤明、冨川直樹、千葉英樹
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] タイト結合分子クローディン-6接着シグナルは子宮内膜癌の悪性形質を増強する2017
- Author(s)
  杉本幸太郎、小島学、田中瑞子、柏木維人、冨川直樹、千葉英樹
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-17K08699
[Presentation] クローディン-6の上皮分化誘導シグナルには、SrcとBlkが機能している2015
- Author(s)
  冨川直樹、柏木維人、杉本幸太郎、千葉英樹
- Organizer
  第104回日本病理学会大会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26670191
[Presentation] 幹細胞の上皮分化誘導機構において、核内受容体とCldn6シグナルがタイト結合分子の転写活性化に与える影響2015
- Author(s)
  柏木維人、冨川直樹、杉本幸太郎、渡部哲也、柳田真衣、千葉英樹
- Organizer
  第104回日本病理学会大会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26670191
[Presentation] タイト結合分子クローディン-4の上皮分化誘導能の解析2015
- Author(s)
  柳沼奈々絵、冨川直樹、柏木維人、杉本幸太郎、千葉英樹
- Organizer
  第104回日本病理学会大会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26670191
[Presentation] Src family kinase involves in the differentiation of stem cells to epithelial cells2012
- Author(s)
  Naoki Tomikawa-Ichikawa, Kotaro Sugimoto, Risa Kanai, Hideki Chiba
- Organizer
  In: Tight junction symposium 2012
- Place of Presentation
  Merida, Mexico.
- Data Source
  KAKENHI-PROJECT-23659187
[Presentation] Tight-junction protein claudin-6 provokes epithelial polarization and cell-cell junction formation in F9 stem cells2012
- Author(s)
  Kotaro Sugimoto, Naoki Ichikawa-Tomikawa, Risa Kanai, Satoshi Tanaka , Norimasa Sawada, Hideki Chiba
- Organizer
  In: Tight junction symposium 2012
- Place of Presentation
  Merida, Mexico
- Data Source
  KAKENHI-PROJECT-23659187
[Presentation] 核内受容体PPAR-γを介したヒト鼻粘膜におけるタイト結合の発現調節機構.2009
- Author(s)
  小笠原徳子, 小島隆, 郷充, 亀倉隆太, 大國毅, 正木智之, 村田雅樹, 田中敏, 千葉英樹, 氷見徹夫, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 膵癌細胞株のPKCシグナル異常におけるタイト結合蛋白の変化.2009
- Author(s)
  伊東竜哉, 小島隆, 山口洋志, 村田雅樹, 田中敏, 千葉英樹, 平田公一, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く2007
- Author(s)
  千葉英樹, 他
- Organizer
  ワークショップ「細胞接着・細胞外基質・細胞間相互作用」第40回日本発生生物学会・第59回日本細胞生物学会大会
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390117
[Presentation] 内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く.ワークショップ「細胞接着・細胞外基質・細胞間相互作用」2007
- Author(s)
  千葉英樹, 村田雅樹, 小山内誠, 二宮孝文, 小島隆, 澤田典均
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 肝疾患の病態とタイト結合.2007
- Author(s)
  澤田典均, 村田雅樹, 小山内誠, 千葉英樹小島隆
- Organizer
  第4回日本病理学会カンファレンス「肝疾患研究の最前線:現状と課題」
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く2007
- Author(s)
  千葉英樹, 村田雅樹, 小山内誠, 二宮孝文, 小島隆, 澤田典均
- Organizer
  ワークショップ「細胞接着・細胞外基質・細胞間相互作用」第40回日本発生生物学会・第59回日本細胞生物学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590398
[Presentation] 細胞間接着と極性形成の制御機構2007
- Author(s)
  千葉英樹
- Organizer
  第53回日本病理学会秋期特別総会
- Place of Presentation
  東京
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 細胞間接着と極性形成の制御機構.2007
- Author(s)
  千葉英樹
- Organizer
  第53回日本病理学会秋期特別総会
- Place of Presentation
  東京
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く2007
- Author(s)
  千葉英樹, 他
- Organizer
  ワークショップ「細胞接着・細胞外基質・細胞間相互作用」第40回日本発生生物学会・第59回日本細胞生物学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 細胞間接着と極性形成の制御機構2007
- Author(s)
  千葉英樹
- Organizer
  第53回日本病理学会秋期特別総会
- Place of Presentation
  東京
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-19590398
[Presentation] A novel mechanism underlying vitamin D-dependent Ca^<2+> absorption between enterocytes.2007
- Author(s)
  千葉英樹, 他
- Organizer
  In: 4th meeting bone biology forum
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19590398
[Presentation] A novel mechanism underlying vitamin D-dependent Ca^<2+> absorption between enterocytes2007
- Author(s)
  Chiba H
- Organizer
  In : 4th meeting Bone Biology Forum
- Place of Presentation
  Shizuoka
- Data Source
  KAKENHI-PROJECT-19590398
[Presentation] マウス乳癌転移モデルの開発と転移関連遺伝子の探索
- Author(s)
  宍戸奈美子、田中瑞子、冨川直樹、千葉英樹、杉野隆
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24501318
[Presentation] マウス転移モデルの作製とmicroarray, in vivo knockdownを用いた転移関連分子の同定
- Author(s)
  杉野隆、千葉英樹、中島孝
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501318

1. SAWADA Norimasa (30154149)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. KOJIMA Takashi (30260764)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
3. TOBIOKA Hirotoshi (90291559)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TOMIKAWA Naoki (80468587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
5. TANAKA Mizuko (40583638)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. 杉本幸太郎 (40791009)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
7. MURATA Masaki (10404592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
8. ENDO Toshiaki (90213595)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 柏木維人 (50722451)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
10. TANAKA Satoshi (30374250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. INATOMI Syuichiro (10437999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. SUGINO Takashi (90171165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. IMURA TETSUYA (00405276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. IKEDA Tatsuru (40202890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小海康夫 (20178239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小山内誠 (60381266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 東智仁 (70515072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 齋藤明 (70791010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 小林信 (60761947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. SHOJI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 沢田典均

# of Collaborated Projects: 0 results

# of Collaborated Products: 52 results
22. 西間木淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 小船戸康英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 丸橋繁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 石亀輝英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 赤澤智宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 馬渕洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chiba Hideki 千葉 英樹

CHIBA Hideki 千葉 英樹

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Novel mechanism of cancer progression by phosphorylation of nuclear receptorsPrincipal Investigator

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Tissue regeneration using the niche signal for stem cellsPrincipal Investigator

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Promotion of cancer progression by aberrant cell adhesion signalingPrincipal Investigator

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Development of a novel direct reprogramming method using cell adhesion signalPrincipal Investigator

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Development of a novel therapy targeting tight-junction protein occludin against hepatitis CPrincipal Investigator

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Regulation of biological barrier and cell polarity formationPrincipal Investigator

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Molecular mechanism of formation and regulation of the biological barrierPrincipal Investigator

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Reconstitution and regulation of the blood-tissue barrierPrincipal Investigator

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Chiba Hideki 千葉英樹

CHIBA Hideki 千葉英樹