Furukawa Koji 古川功治

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FURUKAWA Koji 古川功治

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Researcher Number	00297631
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2010 – 2011: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 2009: National Institute of Advanced Industrial Science and Technology, 年齢軸生命工学研究センター, 研究チーム長 2002: National Institute of Advanced Industrial Science and Technology, Age Dimension Research Center, Senior Research Scientist, 年齢軸生命工学研究センター, 主任研究員 1998 – 2001: 東京理科大学, 生命科学研究所, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Biophysics / Immunology Except Principal Investigator Biophysics
Keywords	Principal Investigator 抗体 / レパートリー / 抗原結合部位 / CDRループ / 親和性成熟 / phage display / repertoire / affinity maturation / antibody / ファージディスプレイ / 蛋白質 / フォールディング … More Except Principal Investigator … More CD / DSC / MHC / TCR / folding / entropy / enthalpy / peptide exchange / アンタゴニスト / アゴニスト / 熱測定 / 酸性小胞 / 熱安定性 / ペプチド交換 / フォールディング / エントロピー / エンタルピー / ピプチド交換 Less

Learning molecular design for acquired induced folding from the affinity maturation of antibodies.Principal Investigator
- Principal Investigator
  
  FURUKAWA Koji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  National Institute of Advanced Industrial Science and Technology
抗体の初期レパートリーと親和性成熟の相関に関する研究Principal Investigator
- Principal Investigator
  
  古川功治
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokyo University of Science
Exploring the immunological and structural basis for obtaining high affinity antibodies facilitating a performance of protein-chip for clinical investigation.Principal Investigator
- Principal Investigator
  
  FURUKAWA Koji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institute of Advanced Industrial Science and Technology (AIST)
  Tokyo University of Science
Biophysical studies of TCR and their ligands, and interactions of them.
- Principal Investigator
  
  KOZONO Haruo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Science University of Tokyo

All 2011 2010 2009 2003 2002 2001 2000

All Journal Article Presentation Book

[Book] バイオサイエンスの新世紀、第3巻「タンパク質の分子設計」(後藤祐児、谷澤克行編)2001
- Author(s)
  古川功治, 中村春木
- Total Pages
  13
- Publisher
  共立出版(東京)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] Conformational analysis of human serum albumin and its non-enzymatic glycation products using monoclonal antibodies.2011
- Author(s)
  Saito K, Hamano K, Nakagawa M, Yugawa K, Muraoka J, Kuba H, Furukawa K, Azuma T
- Journal Title
  
  J.Biochem.
  
  Volume: 149 Pages: 569-580
- NAID
  10030585327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570176
[Journal Article] Conformational analysis of human serum albumin and its non-enzymatic glycation products using monoclonal antibodies2011
- Author(s)
  Keigo Saito, Kuniko Hamano, Masatoshi Nakagawa, Keiko Yugawa, Jin Muraoka, Hiroyoshi Kuba, Koji Furukawa, Takachika Azuma
- Journal Title
  
  J. Biochem
  
  Volume: 149 Issue: 5 Pages: 569-580
- DOI
  10.1093/jb/mvr007
- NAID
  10030585327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570176
[Journal Article] Augmented antibody response with premature germinal center regression in CD40L- transgenic mice.2010
- Author(s)
  Kishi Y, Aiba Y, Higuchi T, Furukawa K, Tokuhisa T, Takemori T, Tsubata T
- Journal Title
  
  J.Immunol.
  
  Volume: 185 Pages: 211-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570176
[Journal Article] Augmented antibody response with premature germinal center regression in CD40L-transgenic mice2010
- Author(s)
  Yusuke Kishi, Yuichi Aiba, Tetsuya Higuchi, Koji Furukawa, Takeshi Tokuhisa, Toshitada Takemori, Takeshi Tsubata
- Journal Title
  
  J. Immunol
  
  Volume: 185 Issue: 1 Pages: 211-219
- DOI
  10.4049/jimmunol.0901694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570176
[Journal Article] An optimized procedure for efficient phage display of antibody fragments with a low folding efficiency.2009
- Author(s)
  Kuba H., Furukawa K.
- Journal Title
  
  Protein Expr.Purif. 65
  
  Pages: 148-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570176
[Journal Article] An optimized procedure for efficient phage display of antibody fragments with a low folding efficiency2009
- Author(s)
  Hiroyoshi Kuba, Koji Furukawa
- Journal Title
  
  Protein Expr. Purif
  
  Volume: 65 Issue: 2 Pages: 148-153
- DOI
  10.1016/j.pep.2009.01.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570176
[Journal Article] Three-dimensional Relationship between H- and L-chain of Antibody.2003
- Author(s)
  Yamamoto Y., Furukawa K., Azuma T.
- Journal Title
  
  Protein Sci. 12-1
  
  Pages: 103-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] Thermodynamic and Kinetic Aspects of Antibody Evolution during the Immune Response to Hapten.2003
- Author(s)
  Sagawa T., Oda M., Ishimura M., Furukawa K., Azuma T.
- Journal Title
  
  Mol.Immunol. 39
  
  Pages: 801-806
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] Three-dimensional Relationship between H- and L-chain of Antibody.2003
- Author(s)
  Yamamoto Y., Furukawa K., Azuma T.
- Journal Title
  
  Protein Sci. 12・1
  
  Pages: 103-103
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] 抗体の基礎研究〜より効率良く有用な抗体を得るために〜2003
- Author(s)
  古川安津子, 古川功治
- Journal Title
  
  医薬ジャーナル 39
  
  Pages: 67-72
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] Exploring high affinity monoclonal antibodies for drug invention2002
- Author(s)
  Furukawa K.
- Journal Title
  
  Nippon Rinsho 60
  
  Pages: 443-450
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] モノクローナル抗体医薬品創製における抗原親和性2002
- Author(s)
  古川功治
- Journal Title
  
  日本臨牀 60
  
  Pages: 445-450
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] プロテインチップに何を託すか2001
- Author(s)
  古川功治
- Journal Title
  
  細胞工学 20
  
  Pages: 1163-1165
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Landscape for Affinity Maturation of Antibody, an Evolutionary Process in Immune Response.2001
- Author(s)
  Furukawa K., Furukawa A., Azuma T.
- Journal Title
  
  Protein Sci. 10-1
  
  Pages: 159-159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Role of the Third Complementarity Determining Region in the Affinity Maturation of an Antibody.2001
- Author(s)
  Furukawa K., Furukawa A., Azuma T.
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 27622-27628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Role of the Third Complementarity Determining Region in the Affinity Maturation of an Antibody.2001
- Author(s)
  Furukawa K., Shirai H., Azuma T, Nakamura H
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 27622-27628
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Landscape for Affinity Maturation of Antibody, an Evolutionary Process in Immune Response.2001
- Author(s)
  Furukawa K., Furukawa A., Azuma T.
- Journal Title
  
  Protein Sci. 10・1
  
  Pages: 159-159
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] 抗体の進化経路は複数存在する-抗体医薬品創製に向けて-2000
- Author(s)
  古川功治, 白井宏樹
- Journal Title
  
  ファルマシア 36
  
  Pages: 689-693
- NAID
  110003660654
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] junctional diversityと免疫応答の成熟2000
- Author(s)
  古川功治, 東隆親
- Journal Title
  
  臨床免疫 33
  
  Pages: 719-726
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] 抗体分子の成熟2000
- Author(s)
  古川功治
- Journal Title
  
  アレルギー科 9
  
  Pages: 447-453
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Presentation] Memory B cells generate the VH gene repertoire in the secondary response, distinct from that found in the primary antibody response2010
- Author(s)
  Tomohiro Kaji, Koji Furukawa, Michiko Shimoda, Toshitada Takemori
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570176
[Presentation] 血清アルブミンの高次構造変化を識別する抗体の分子プローブとしての熱力学的評価2009
- Author(s)
  齊藤桂吾、濱野邦子、久芳弘義、古川功治、東隆親
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21570176

1. NAKAMURA Haruki (80134485)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. KOZONO Haruo (80287482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. AZUMA Takachika (00028234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. KOJIMA Masaharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ARIKUNI Hisashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Furukawa Koji 古川 功治

FURUKAWA Koji 古川 功治

Research Projects

Research Products

Co-Researchers

Learning molecular design for acquired induced folding from the affinity maturation of antibodies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗体の初期レパートリーと親和性成熟の相関に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring the immunological and structural basis for obtaining high affinity antibodies facilitating a performance of protein-chip for clinical investigation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biophysical studies of TCR and their ligands, and interactions of them.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] バイオサイエンスの新世紀、第3巻「タンパク質の分子設計」(後藤祐児、谷澤克行編)2001

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Conformational analysis of human serum albumin and its non-enzymatic glycation products using monoclonal antibodies.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Conformational analysis of human serum albumin and its non-enzymatic glycation products using monoclonal antibodies2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Augmented antibody response with premature germinal center regression in CD40L- transgenic mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Augmented antibody response with premature germinal center regression in CD40L-transgenic mice2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An optimized procedure for efficient phage display of antibody fragments with a low folding efficiency.2009

Author(s)

Journal Title

Data Source

[Journal Article] An optimized procedure for efficient phage display of antibody fragments with a low folding efficiency2009

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-dimensional Relationship between H- and L-chain of Antibody.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Thermodynamic and Kinetic Aspects of Antibody Evolution during the Immune Response to Hapten.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Three-dimensional Relationship between H- and L-chain of Antibody.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] 抗体の基礎研究〜より効率良く有用な抗体を得るために〜2003

Furukawa Koji 古川功治

FURUKAWA Koji 古川功治