Koyama Tadashi 幸山正

… Alternative Names

KOHYAMA Tadashi 幸山正

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Researcher Number	00302703
Other IDs
Affiliation (Current)	2025: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2014: 帝京大学, 医学部, 教授 2012 – 2013: 帝京大学, 医学部, 准教授 2007: The University of Tokyo, Respiratory medicine, Lecturer 2006 – 2007: 東京大学, 医学部附属病院, 特任講師 2005: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator inflammatory cells / remodeling / mast cells / contractility / cell migration / Lung fibroblast / 炎症性細胞 / 気道リモデリング / 肥満細胞 / 収縮能 / 細胞遊走 / 肺線維芽細胞 … More Except Principal Investigator … More TGFbeta / cvtokine / epithelial mesench mal transition / remodelin / myofibroblast / cell signalling / cell migration / smooth muscle cells / 成長因子 / 炎症性細胞 / 細胞増殖 / TGFβ1 / TGF β1 / サイトカイン / 上皮間葉移行 / 気道リモデリング / 筋線維芽細胞 / 細胞内シグナル経路 / 細胞遊走 / 気道平滑筋細胞 / 敗血症 / defensin / 急性肺損傷 / ATP / 抗菌ペプチド / EMT / LIGHT/ TNFSF14 / Vimentin / E-cadherin / LIGHT/TNFSF14 / 上皮間葉転換 / EGFR / ブレオマイシン / マウス / EGFRファミリー / プロテオグリカン / 肺線維症 Less

Mechanism of epithelial mesenchymal transition induced by LIGHT/TNFSF14
- Principal Investigator
  
  YAMAUCHI Yasuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
The role of extracellular ATP and antimicrobial peptide, denfesin in inflammatory lung diseases
- Principal Investigator
  
  YAMAGUCHI Yasuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
The role of proteoglycans in the modulation of EGFR family and it's ligand in lung fibrosis
- Principal Investigator
  
  JO Taisuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
Role of aging lung fibroblast in the allergic airway inflammationPrincipal Investigator
- Principal Investigator
  
  KOHYAMA Tadashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
Interactions between airway smooth murle cells and inflammatory cells in the pathogenesis of asthma
- Principal Investigator
  
  TAKIZAWA Hajime
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Teikyo University
  The University of Tokyo

All 2014 2013 2012 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells.2014
- Author(s)
  Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, Kohyama T, Takizawa H, Nagase T, Yamauchi Y.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: 1-21
- DOI
  10.1371/journal.pone.0114791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22240066, KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-24591125
[Journal Article] Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor2014
- Author(s)
  Horie M, Saito A, Yamauchi Y, Mikami Y, Sakamoto M, Jo T, Takizawa H, Nagase T, Kohyama T
- Journal Title
  
  Experimental Lung Research
  
  Volume: 未確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591139
[Journal Article] Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor.2014
- Author(s)
  5.Horie M, Saito A, Yamauchi Y, Mikami Y, Sakamoto M, Jo T, Nakajima J, Takizawa H, Nagase T, Kohyama T.
- Journal Title
  
  Exp Lung Res.
  
  Volume: 40 Issue: 5 Pages: 222-36
- DOI
  10.3109/01902148.2014.900155
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-23591139, KAKENHI-PROJECT-23790899, KAKENHI-PROJECT-24591154, KAKENHI-PROJECT-26461185
[Journal Article] Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.2012
- Author(s)
  Mikami Y
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 428 Issue: 4 Pages: 451-7
- DOI
  10.1016/j.bbrc.2012.10.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-23591139, KAKENHI-PROJECT-24591125
[Journal Article] Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains2008
- Author(s)
  Li, YJ., Kawada, T., Takizawa, H., Azuma, A., Kudoh, S., Sugawara, I., Yamauchi, Y., Kohyama, T
- Journal Title
  
  Exp Lung Res 34(3)
  
  Pages: 125-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390242
[Journal Article] Condition, treatment and management of disease of old pathient ; The functions of old lung fibroblasts2007
- Author(s)
  Tadashi Kohyama
- Journal Title
  
  Kokyukika 12
  
  Pages: 556-560
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590839
[Journal Article] 高齢者呼吸器疾患の病態と治療・管理-老化肺線維芽細胞機能2007
- Author(s)
  幸山正
- Journal Title
  
  呼吸器科 12:6
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590839
[Journal Article] 高齢者喘息の特徴と対策高齢者喘息の病態- 免疫アレルギー所見2006
- Author(s)
  幸山正
- Journal Title
  
  臨床免疫・アレルギー科 46(4)
  
  Pages: 371-76
- Data Source
  KAKENHI-PROJECT-17390242
[Journal Article] 高齢者喘息の特徴と対策高齢者喘息の病態-免疫アレルギー所見2006
- Author(s)
  幸山正
- Journal Title
  
  臨床免疫・アレルギー科 46(4):
  
  Pages: 371-376
- Data Source
  KAKENHI-PROJECT-18590839
[Journal Article] Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts2005
- Author(s)
  Kato, J., Kohyama, T., Okazaki, H., Desaki, M., Nagase, T., Rennard, SI., Takizawa, H
- Journal Title
  
  Clin Immunol 117(2)
  
  Pages: 177-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390242
[Presentation] Interleukin-17A Enhances Interferon- Gamma-Induced CXCL10/IP-10 Production In BEAS-2B Human Bronchial Epithelial Cells2013
- Author(s)
  Yasuhiro Yamauchi, Taisuke Jo, Masafumi Horie, Yu Mikami, Satoshi Noguchi, Osamu Narumoto, Kazutaka Takami, Tadashi Kohyama, Hajime Takizawa, Takahide Nagase
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Pennsylvania Convention Center
- Data Source
  KAKENHI-PROJECT-23591139
[Presentation] Interleukin-17A Enhances Interferon-Gamma-Induced CXCL10/IP-10 Production In BEAS-2B Human Bronchial Epithelial Cells.2013
- Author(s)
  Yasuhiro Yamauchi, Taisuke Jo, Masafumi Horie, Yu Mikami, Satoshi Noguchi, Osamu Narumoto, Kazutaka Takami, Tadashi Kohyama, Hajime Takizawa, Takahide Nagase,
- Organizer
  American Thoracic Society　International Conference 2013
- Place of Presentation
  Pennsylvania convention center (アメリカ、フィラデルフィア）
- Data Source
  KAKENHI-PROJECT-23591139
[Presentation] Tumor Necrosis Factor Super Family Member LIGHT Induces CXCL8 Production In BEAS-2B Human Bronchial Epithelial Cells Via Erk1/2 Pathway.2013
- Author(s)
  Yu Mikami, Yasuhiro Yamauchi, Masafumi Horie, Satoshi Noguchi, Osamu Narumoto, Taisuke Jo, Tadashi Kohyama, Hajime Takizawa, Takahide Nagase
- Organizer
  American Thoracic Society　International Conference 2013
- Place of Presentation
  Pennsylvania convention center (アメリカ、フィラデルフィア）
- Data Source
  KAKENHI-PROJECT-23591139
[Presentation] Tumor Necrosis Factor Super Family Member LIGHT Induces CXCL8 Production In BEAS-2B Human Bronchial Epithelial Cells Via Erk1/2 Pathway2013
- Author(s)
  Y Mikami, Y Yamauchi, M Horie, S Noguchi, O Narumoto, T Jo, T Kohyama, H Takizawa, T Nagase
- Organizer
  American Thoracic Society International Conference 2013
- Place of Presentation
  Penｎsylvania convention center (アメリカ・フィラデルフィア)
- Data Source
  KAKENHI-PROJECT-24591125
[Presentation] Tumor Necrosis Factor Super Family Member LIGHT Induces CXCL8 Production In BEAS-2B Human Bronchial Epithelial Cells Via Erk1/2 Pathway2013
- Author(s)
  Yu Mikami, Yasuhiro Yamauchi, Masafumi Horie, Satoshi Noguchi, Osamu Narumoto, Taisuke Jo, Tadashi Kohyama, Hajime Takizawa, Takahide Nagase
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Pennsylvania Convention Center
- Data Source
  KAKENHI-PROJECT-23591139
[Presentation] Tumor Necrosis Factor Superfamily Member LIGHT (TNFSF14) Induces Epithelial-Mesenchymal Transition In A549 Human Airway Epithelial Cells2012
- Author(s)
  Y Mikami, Y Yamauchi, T Kohyama, M Horie, A Saito, T Jo, H Takizawa, T Nagase
- Organizer
  American Thoracic Society International conferrence 2012
- Place of Presentation
  The Moscone Center （アメリカ・サンフランシスコ）
- Data Source
  KAKENHI-PROJECT-24591125
[Presentation] Chemokine profiles of A549 human alveolar epithelial cells that underwent epithelial-mesenchymal transition by TGF-b and/or TNF-a2012
- Author(s)
  Y Yamauchi, M Horie, A Saito, T Jo, Y Mikami, H Takizawa, T Nagase, T Kohyama
- Organizer
  European Respiratory Society Annual congress 2012
- Place of Presentation
  Reed Messe Wien （オーストリア・ウィーン）
- Data Source
  KAKENHI-PROJECT-24591125
[Presentation] 老化肺線維芽細胞機能の検討2007
- Author(s)
  板倉進、幸山正、長瀬隆英
- Organizer
  第49回日本老年医学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2007-06-22
- Data Source
  KAKENHI-PROJECT-18590839
[Presentation] clarithromycin inhibits migration of lung fibroblast2006
- Author(s)
  Kohyama, T., Takizawa, H., Kato, J., Kikuchi, K., Yamauchi, Y., Takami, K., Okazaki, H., Ishii, A., Nagase, T
- Organizer
  The 11th Cogress of the Asian Pacific Society of respirology
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390242
[Presentation] Methotrexate induces proinflammatory cytokines production by human bronchial and alveolar epithelial cells2006
- Author(s)
  Yamauchi, Y., Okazaki, H., Desaki, M., Kohyama, T., Takizawa, H., Nagase, T
- Organizer
  The 11th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390242

1. JO Taisuke (30376470)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. YAMAUCHI Yasuhiro (00323585)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. TAKIZAWA Hajime (80171578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. DESAKI Masashi (30251250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SAITO Akira (90591412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. NAGASE Takaide (40208004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. YAMAGUCHI Yasuhiro (60376473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMAMOTO Hiroshi (10361487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 滝沢始

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Koyama Tadashi 幸山 正

KOHYAMA Tadashi 幸山 正

Research Projects

Research Products

Co-Researchers

Mechanism of epithelial mesenchymal transition induced by LIGHT/TNFSF14

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of extracellular ATP and antimicrobial peptide, denfesin in inflammatory lung diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of proteoglycans in the modulation of EGFR family and it's ligand in lung fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of aging lung fibroblast in the allergic airway inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interactions between airway smooth murle cells and inflammatory cells in the pathogenesis of asthma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor2014

Author(s)

Journal Title

Data Source

[Journal Article] Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Condition, treatment and management of disease of old pathient ; The functions of old lung fibroblasts2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] 高齢者呼吸器疾患の病態と治療・管理-老化肺線維芽細胞機能2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] 高齢者喘息の特徴と対策 高齢者喘息の病態- 免疫アレルギー所見2006

Author(s)

Journal Title

Data Source

[Journal Article] 高齢者喘息の特徴と対策 高齢者喘息の病態-免疫アレルギー所見2006

Author(s)

Journal Title

Data Source

[Journal Article] Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts2005

Author(s)

Journal Title

Koyama Tadashi 幸山正

KOHYAMA Tadashi 幸山正

[Journal Article] 高齢者喘息の特徴と対策高齢者喘息の病態- 免疫アレルギー所見2006

[Journal Article] 高齢者喘息の特徴と対策高齢者喘息の病態-免疫アレルギー所見2006