SHITARA Yoshihisa 設楽悦久

… Alternative Names

設楽悦久シタラヨシヒサ

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Researcher Number	00306656
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2012: 千葉大学, 薬学研究科(研究院), 准教授 2009 – 2012: Chiba University, 大学院・薬学研究院, 准教授 2007: Chiba University, 大学院・薬学研究院, 准教授 2007: Chiba University, Graduate School of Pharmaceutical Sciences, Lecturer 2006: 千葉大学, 大学院薬学研究院, 講師 … More 2005: Chiba University, Graduate School of Pharmaceutical Sciences, Lecturer, 大学院・薬学研究院, 講師 2003 – 2004: 昭和大学, 薬学部, 助手 2000 – 2001: 北里大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / 医薬分子機能学 Except Principal Investigator Physical pharmacy / Medical pharmacy
Keywords	Principal Investigator トランスポーター / 薬物間相互作用 / シクロスポリン / OATP1B3 / OATP1B1 / Oatp / トログリタゾン / アミオダロン / フェンホルミン / OCTN1 … More / ミトコンドリア / OATP / 肝取り込み / 消化管吸収 / 持続的阻害 / OATP/Oatp / 代謝学 / 薬物動態 / BSP / 非可逆的阻害 / Oatp1a1 / 阻害機序解明 / HMG-CoA還元酵素阻害薬 / セリバスタチン / ゲムフィブロジルグルクロニド / ゲムフィブロジル / mechanism-based inhibition / 肝細胞 … More Except Principal Investigator Mrps / biliary excretion / トランスポーター / 胆汁排泄 / MRP2 / 国際情報交換 / 薬学 / Protein / Drug reactivity / Signal transduction / Biophysical / 蛋自質 / 蛋白質 / 薬剤反応性 / シグナル伝達 / 生物物理 / drug-drue interaction / renal excretion / anti-HIV drugs / diuretics / transporters / metabolic enzymes / CYP3A4 / SULT / Mrp4 / Mrp3 / 小腸吸収 / 薬物間相互作用 / 腎排泄 / HIV治療薬 / 利尿薬 / 代謝酵素 / nitric oxide / protein kinase C / transporter / glutathione / cholestasis / oxidative stress / 脂質過酸化 / 化学発光 / 肝障害 / 酸化的ストレス / 一酸化窒素 / Protein kinase C / グルタチオン / 胆汁うっ滞 / 酸化ストレス / 薬剤反応生 / 代謝学 / 薬物動態 / 臨床 / 放射線 / プロテオーム Less

Quantitative analysis of drugs induced BSEP inhibition and cholestatic hepatotoxicity
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
薬剤による毒性発症に関わる因子としてのミトコンドリア内への担体介在性輸送Principal Investigator
- Principal Investigator
  
  設楽悦久
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Molecular analysis of localization of biliary transporters in chronic hepatitis
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Mechanism of long-lasting inhibition of transporters as a mechanism of transporter-related drug-drug interactionsPrincipal Investigator
- Principal Investigator
  
  SHITARA Yoshihisa
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Intrahepatic imaging and molecular analysis of MRP2 localization regulated by the intracellular redox status
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
薬物投与によるトランスポーター機能変化の定量的解析および機序解明Principal Investigator
- Principal Investigator
  
  設楽悦久
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
MRP2 mediated defense against oxidative stress in liver
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
HMG-CoA還元酵素阻害薬と他剤併用時の薬物間相互作用のメカニズム解析Principal Investigator
- Principal Investigator
  
  設楽悦久
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa University
薬物トランスポーターを介した取り込み過程で生じる薬物間相互作用の定量的予測Principal Investigator
- Principal Investigator
  
  設楽悦久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kitasato University

All 2013 2012 2011 2010 2009 2007 2006 2004 Other

All Journal Article Presentation Book

[Book] Extrapolationod In vitro Metabolic and P-Glycoprotein-mediated Transport data to In vivo by Modeling and Simulations, in "Enzyme- and Transporter-Based drug-drug interactions"2010
- Author(s)
  Kato M, Shitara Y, Kitajima M, Tachibana T, Igarashi M, Horie T, Sugiyama Y
- Publisher
  Springer, NY, USA
- Data Source
  KAKENHI-PROJECT-23659073
[Book] Web-Based Database as a Tool to examine drug-drug interactions involving transporters in Enzyme- and Transporter-Based drug-drug interactions"2010
- Author(s)
  Maeda K, Shitara Y, Horie T, Sugiyama Y.
- Publisher
  Springer, NY, USA
- Data Source
  KAKENHI-PROJECT-23659073
[Book] 薬物トランスポーター活用ライブラリー(第3章2-(3)スタチン系高脂血症治療薬の薬物間相互作用に関わるトランスポーター)2010
- Author(s)
  設楽悦久(乾賢一編集)
- Total Pages
  2
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21790142
[Book] Extrapolationod In vitro Metabolic and P-Glycoprotein-mediated Transport data to In vivo by Modeling and Simulations, in "Enzyme- and Transporter-Based drug-drug interactions"2010
- Author(s)
  Kato M, Shitara Y, Kitajima M, Tachibana T, Igarashi M, Horie T, Sugiyama Y.
- Publisher
  Springer, NY, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Book] 薬物トランスポーター活用ライブラリー(第3章2-(3)スタチン系高脂血症治療薬の薬物間相互作用に関わるトランスポーター)(乾賢一編集)2010
- Author(s)
  設楽悦久
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21790142
[Book] 最新創薬学2007(分担執筆:輸送における薬物間相互作用)2007
- Author(s)
  設楽悦久
- Total Pages
  8
- Publisher
  メディカル・ドゥ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Book] 最新創薬学2007(分担執筆:輸送における薬物間相亙作用)2007
- Author(s)
  設楽悦久
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-17209005
[Book] Drug-drug interactions in pharmaceutical development2007
- Author(s)
  Shitara Y, Horie T, Sugiyama Y
- Total Pages
  244
- Publisher
  John Wiley and Sons
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Book] Drug-drug interactions in pharmaceutical development (ed.Albert P.Li) 6 Transporters and drug interactions pp. 131-1572007
- Author(s)
  Yoshihisa Shitara,
- Total Pages
  26
- Publisher
  John Wiley and Sons
- Data Source
  KAKENHI-PROJECT-17790130
[Book] 遺伝子医学MOOK7号最新創薬学2007-薬物動態特性の解析は創薬のキーワード-(杉山雄一編)第2章2-(5)輸送における薬物間相互作用pp.155-1622007
- Author(s)
  設楽悦久
- Total Pages
  7
- Publisher
  メディカルドゥ社
- Data Source
  KAKENHI-PROJECT-17790130
[Journal Article] Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect oncomplex I respiration in mitochondria.2013
- Author(s)
  Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T.
- Journal Title
  
  Toxicol Sci.
  
  Volume: 132(1) Pages: 32-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibitory effects of saquinavir and ritonavir on OATP1B1-mediated uptake2013
- Author(s)
  Shitara Y, Takeuchi K, Horie T.
- Journal Title
  
  J Pharm Sci
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibitory effects of saquinavir and ritonavir on OATP1B1-mediated uptake.2013
- Author(s)
  Shitara Y, Takeuchi K, Horie T.
- Journal Title
  
  J Pharm Sci.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Clinical significanceof organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.2013
- Author(s)
  Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 34(1) Pages: 45-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The Mechanism of the Down-Regulation of Hepatic Transporters in Rats with Indomethacin-Induced Intestinal Injury2013
- Author(s)
  Fujiyama N, Shitara Y, Horie T.
- Journal Title
  
  Dig Dis Sci
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption2013
- Author(s)
  Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y.
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 34(1) Pages: 45-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] The Mechanism of the Down-Regulation of Hepatic Transporters in Rats with Indomethacin-Induced Intestinal Injury.2013
- Author(s)
  Fujiyama N, Shitara Y, Horie T.
- Journal Title
  
  DigDis Sci.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect oncomplex I respiration in mitochondria2013
- Author(s)
  Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T.
- Journal Title
  
  Toxicol Sci
  
  Volume: 132(1) Pages: 32-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting Inhibitory Effects of Cyclosporin A, but Not Tacrolimus, on OATP1B1- and OATP1B3-mediated Uptake2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 27 Issue: 4 Pages: 368-378
- DOI
  10.2133/dmpk.DMPK-11-RG-096
- NAID
  130004463264
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats2012
- Author(s)
  Suzuki K, Shitara Y, Fukuda K, Horie T.
- Journal Title
  
  J Pharm Sci
  
  Volume: 101(7) Pages: 2606-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- andOATP1B3-mediated uptake.2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug MetabPharmacokinet.
  
  Volume: 27(4) Pages: 368-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- andOATP1B3-mediated uptake2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27(4) Pages: 368-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats.2012
- Author(s)
  Suzuki K, Shitara Y, Fukuda K, Horie T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101 Issue: 7 Pages: 2606-2615
- DOI
  10.1002/jps.23174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: (In press)
- NAID
  130004463264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 144 Issue: 3 Pages: 612-617
- DOI
  10.1016/j.jep.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporinA in rats.2012
- Author(s)
  Suzuki K, Shitara Y, Fukuda K, Horie T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101(7) Pages: 2606-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Potential P-glycoprotein-mediateddrug-drug interactions of antimalarial agents in Caco-2 cells.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 87(1) Pages: 64-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Potential P-glycoprotein-mediateddrug-drug interactions of antimalarial agents in Caco-2 cells2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg
  
  Volume: 87(1) Pages: 64-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Potential P-glycoprotein-mediated drug-drug interactions of antimalarial agents in Caco-2 cells.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 87 Issue: 1 Pages: 64-69
- DOI
  10.4269/ajtmh.2012.11-0817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Clinical importance of OATP1B1 and OATP1B3 in drug-drug interactions2011
- Author(s)
  Yoshihisa Shitara
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: (in press)
- NAID
  130004463181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790142
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women.2011
- Author(s)
  Tanii H, Shitara Y, Horie T.
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 67(10) Pages: 1017-1025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women.2011
- Author(s)
  Tanii H, Shitara Y, Horie T.
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 67(10) Pages: 1017-25
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women2011
- Author(s)
  Tanii H, Shitara Y, Horie T.
- Journal Title
  
  Eur J Clin Pharmacol
  
  Volume: 67(10) Pages: 1017-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women2011
- Author(s)
  Tanii H, Shitara Y, Horie T
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 67(10) Pages: 1017-1025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada, K., Shitara, Y., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition.2010
- Author(s)
  Okuda T, Norioka M, Shitara Y, Horie T.
- Journal Title
  
  Toxicol ApplPharmacol.
  
  Volume: 248(3) Pages: 242-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition2010
- Author(s)
  Okuda T, Norioka M, Shitara Y, Horie T.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 248 Pages: 242-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada K, Shitara Y, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 66(6) Pages: 1031-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibition of the transporter-mediated hepatic up atake of sulfobromophthalein by cyclosporine A in rats.2009
- Author(s)
  Shitara, Y., Nagamatsu, Y., Wada, S., Sugiyama, Y., Horie, T.
- Journal Title
  
  Drug.Metab.Dispos. 37
  
  Pages: 1172-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats.2009
- Author(s)
  Shitara Y, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 37(6) Pages: 1172-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T.
- Journal Title
  
  Biol Pharm Bull. 30(3)
  
  Pages: 556-61
- NAID
  110006239203
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T
- Journal Title
  
  Biol. Pharm. Bull. 30 (3)
  
  Pages: 556-561
- NAID
  110006239203
- Data Source
  KAKENHI-PROJECT-17790130
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T.
- Journal Title
  
  Biol Pharm Bull. 30 (3)
  
  Pages: 556-561
- NAID
  110006239203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Transporter-mediated Drug-Drug interaction2007
- Author(s)
  Shitara Y
- Journal Title
  
  Novel Drug Development 2007 (Medical Do)
  
  Pages: 149-1547
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Down-regulation of hepatic transporters for BSP in rats withindomethacin-induced intestinal injury2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T.
- Journal Title
  
  Biol Pharm Bull 30(3)
  
  Pages: 556-561
- NAID
  110006239203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Drug-drug interactions in pharmaceutical development2007
- Author(s)
  Shitara Y, Horie T, Sugiyama Y.
- Journal Title
  
  John Wiley and Sons 244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T
- Journal Title
  
  Biol Pharm Bull. 30(3)
  
  Pages: 556-61
- NAID
  110006239203
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors : drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions.2006
- Author(s)
  Shitara Y, Sugiyama Y
- Journal Title
  
  Pharmacol. Ther. 112 (1)
  
  Pages: 71-105
- Data Source
  KAKENHI-PROJECT-17790130
[Journal Article] Vectorial transport of enalapril by Oatplal/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers2006
- Author(s)
  Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D, Pang KS
- Journal Title
  
  J Pharmacol Exp Ther 318 (1)
  
  Pages: 395-402
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Abstract Drug-drug interaction between pitavastatin and various drugs via OATP1B1.2006
- Author(s)
  Hirano M, Maeda K, Shitara Y, Sugiyama Y
- Journal Title
  
  Drug Metab. Dispos. 34 (7)
  
  Pages: 1229-1236
- Data Source
  KAKENHI-PROJECT-17790130
[Journal Article] Transporters as a determinant of drug clearance and tissue distribution.2006
- Author(s)
  Shitara Y, Horie T, Sugiyama Y
- Journal Title
  
  Eur. J. Pharm. Sci. 27 (5)
  
  Pages: 425-446
- Data Source
  KAKENHI-PROJECT-17790130
[Journal Article] Vectorial transport of enalapril by Oatpla1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers.2006
- Author(s)
  Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D, Pang KS
- Journal Title
  
  J. Pharmacol. Exp. Ther. 318 (1)
  
  Pages: 395-402
- Data Source
  KAKENHI-PROJECT-17790130
[Journal Article] Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin : Analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil2004
- Author(s)
  Yoshihisa Shitara, Masaru Hirano, Hitoshi Sato, Yuichi Sugiyama
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 311(1)
  
  Pages: 228-236
- Data Source
  KAKENHI-PROJECT-15790099
[Journal Article] In vitro and in vivo correlation of the inhibitory effect of cyclosporin A on the transporter-mediated hepatic uptake of cerivastatin in rats2004
- Author(s)
  Yoshihisa Shitara, Masaru Hirano, Yasuhisa Adachi, Tomoo Itoh, Hitoshi Sato, Yuichi Sugiyama
- Journal Title
  
  Drug Metabolism and Disposition 32(12)
  
  Pages: 1468-1475
- Data Source
  KAKENHI-PROJECT-15790099
[Journal Article] Cliniccacl Importance of OATP1B1 and OATP1B3 in drug-drug interactions.
- Author(s)
  Yoshihisa Shitara
- Journal Title
  
  Drug Metab.Pharmacokinet. in press
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] Fexofenadineとcyclosporin Aの消化管吸収過程で生じるトランスポーターを介した薬物間相互作用2011
- Author(s)
  鈴木敬,設楽悦久,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Fexofenadineとcyclosporin Aの消化管吸収過程で生じるトランスポーターを介した薬物間相互作用2011
- Author(s)
  鈴木敬、設楽悦久、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター、静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] Phenforminによる毒性に対するミトコンドリア輸送担体の関与の解明2011
- Author(s)
  則岡美咲、設楽悦久、中道範隆、加藤将夫、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Phenforminによる毒性に対するミトコンドリア輸送担体の関与の解明2011
- Author(s)
  則岡美咲,設楽悦久,中道範隆,加藤将夫,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Fexofenadineとcyclosporin Aの消化管吸収過程で生じるトランスポーターを介した薬物間相互作用2011
- Author(s)
  鈴木敬、設楽悦久、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] POTENTIAL P-GLYCOPROTEIN MEDIATED DRUG-DRUG INTERACTIONS OF SOME ANTI-MALARIALS2011
- Author(s)
  Enoche F.Oga、関根秀一、設楽悦久、堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Fexofenadineとcyclosporin Aの消化管吸収過程で生じるトランスポーターを介した薬物間相互作用2011
- Author(s)
  鈴木敬、設楽悦久、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] フェンホルミンによって引き起こされるミトコンドリア障害に対するOCTN1/Octn1の関与2011
- Author(s)
  菊田奈津子、設楽悦久、則岡美咲、中道範孝、加藤将夫、堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] シクロスポリンAによる肝トランスポータ-OATPの阻害機序の解析2010
- Author(s)
  竹内久美子、設楽悦久、永松佳子、和田怜美、杉山雄一、堀江利治
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Mitochondrial uptake of organic cations as one of determinants of liver specific toxicity by phenformin2010
- Author(s)
  Misaki Norioka, Yoshihisa Shitara, Toshiharu Horie
- Organizer
  Pharmaceutical Sciences 2010 World Congress/AAPS annual meeting and exposition
- Place of Presentation
  Morial Convention Center, New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサートによる小腸上皮バリア機能障害の機序解析.2010
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] ラットにおけるclofibrate投与による有機アニオントランスポーターOatpの活性変動の機序解析2010
- Author(s)
  和田怜美、設楽悦久、堀江利治
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター、岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] シクロスポリンによる肝トランスポーターOATPの阻害機序の解析2010
- Author(s)
  竹内久美子、設楽悦久、永松佳子、和田怜美、杉山雄一、堀江利治
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学、東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] Long-lasting inhibition of human organic anion transporting polypeptides 1B1 and 1B3 by cyclosporin A2010
- Author(s)
  Yoshihisa Shitara, Kumiko Takeuchi, Satomi Wada, Yoshiko Nagamatsu, Yuichi Sugiyama, Toshiharu Horie
- Organizer
  Pharmaceutical Sciences 2010 World Congress/AAPS annual meeting and exposition
- Place of Presentation
  Morial Convention Center, New Orleans, LA, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] ラットにおけるclofibrate投与による有機アニオントランスポーターOatpの活性変動の機序解析2010
- Author(s)
  和田怜美, 設楽悦久, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] シクロスポリンAによる肝トランスポーターOATPの阻害機序の解析2010
- Author(s)
  竹内久美子、設楽悦久、永松佳子、和田怜美、杉山雄一、堀江利治
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学,東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2010
- Author(s)
  関根秀一、設楽悦久、堀江利治
- Organizer
  37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Effect of CYP3A inhibitors on troglitazone-induced mitochondrial toxicity2010
- Author(s)
  Yoshihisa Shitara, Toshiharu Horie
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Long-lasting inhibition of human organic anion transporting polypeptides 1B1 and 1B3 by cyclosporin A2010
- Author(s)
  Yoshihisa Shitara, Kumiko Takeuchi, Satomi Wada, Yoshiko Nagamatsu, Yuichi Sugiyama, Toshiharu Horie
- Organizer
  Pharmaceutical Sciences 2010 World Congress/AAPS annual meeting and exposition
- Place of Presentation
  Morial Convention Center, New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] ラット肝ミトコンドリアにおける有機アニオン性化合物取り込みの解析2010
- Author(s)
  藤野亮、設楽悦久、堀江利治
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2010
- Author(s)
  関根秀一、設楽悦久、関根秀一
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Mitochondrial uptake of organic cations as one of determinants of phenformin-induced lactic acidosis2010
- Author(s)
  Misaki Norioka, Yoshihisa Shitara, Noritaka Nakamichi, Yukio Kato, Toshiharu Horie
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] シクロスポリンによるOATP1B1およびOATP1B3の持続的阻害2009
- Author(s)
  設楽悦久、竹内久美子、和田怜美、永松佳子、杉山雄一、堀江利治
- Organizer
  第3回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  九州大学病院地区コラボステーション、福岡
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] メトトレキサートによる小腸上皮透過性亢進の機序検討.2009
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬剤学会第24年会講演要旨集
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Comparative inhibitory effect of cyclosporine A and tacrolimus on the OATP1B1- and OATP1B3-mediated uptake2009
- Author(s)
  設楽悦久、竹内久美子、和田怜美、永松佳子、杉山雄一、堀江利治
- Organizer
  日本薬物動態学会第24年会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] The mechanisms of enhanced paracellular permability in the small intestine of MTX-treated rats.2009
- Author(s)
  Hamada, K, Shitara, Y, Sekine, S, Horie, T.
- Organizer
  Advances in Inframmatory Bowel Diseases Crohn's & Colitis Foundation's & Clinical Conference
- Place of Presentation
  Hollywood, USA
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] フェンホルミンのミトコンドリア毒性に対する有機カチオン輸送系の関与.2009
- Author(s)
  則岡美咲, 設楽悦久, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 免疫仰制薬シクロスポリンおよびタクロリムによるOATP1B1およびOATP1B3に対する阻害効果の比較検討.2009
- Author(s)
  設楽悦久, 竹内久美子, 和田怜美, 永松佳子, 杉山雄一, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] フェンホルミンの肝毒性に対するミトコンドリア有機カチオン輸送担体の関与2009
- Author(s)
  則岡美咲, 設楽悦久, 堀江利治
- Organizer
  第3回次世代を担う若手医療科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] シクロスポリンによるOATP1B1およびOATP1B3の持続的阻害2009
- Author(s)
  設楽悦久, 竹内久美子, 和田怜美, 永松佳子, 杉山雄一, 堀江利治
- Organizer
  第3回次世代を担う若手医療科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] COMPARATIVE INHIBITORY EFFECT OF CYCLOSPORIN A AND TACROLIMUS ON THE OATP1B1-AND OATP1B3-MEDIATED UPTAKE2009
- Author(s)
  設楽悦久、竹内久美子、和田怜美、永松佳子、杉山雄一、堀江利治
- Organizer
  日本薬物動態学会第24年会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] シクロスポリンによるOATP1B1およびOATP1B3の持続的阻害2009
- Author(s)
  設楽悦久、竹内久美子、和田怜美、永松佳子、杉山雄一、堀江利治
- Organizer
  第3回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  九州大学病院地区コラボステーション(福岡県)
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-21790142
[Presentation] Inhibition of BSP transport by cyclosporin A in rat hepatocytes2007
- Author(s)
  設楽悦久
- Organizer
  4th World congress on drug absorption, transport and delivery
- Place of Presentation
  石川県金沢市
- Data Source
  KAKENHI-PROJECT-17790130
[Presentation] 薬物による肝トランスポーターの非可逆的阻害2007
- Author(s)
  設楽悦久
- Organizer
  第29回日本中毒学会総会・学術集会
- Place of Presentation
  東京都品川区
- Data Source
  KAKENHI-PROJECT-17790130
[Presentation] トランスポーターを介する薬物相互作用評価法2007
- Author(s)
  設楽悦久
- Organizer
  第21回日本薬物動態学会ワークショップ
- Place of Presentation
  東京都品川区
- Data Source
  KAKENHI-PROJECT-17790130
[Presentation] Cyclosporin Aによるトランスポーターレベルでの薬物間相互作用の機序解析2007
- Author(s)
  設楽悦久
- Organizer
  第22回日本薬剤学会年会
- Place of Presentation
  埼玉県さいたま市
- Data Source
  KAKENHI-PROJECT-17790130
[Presentation] Involvement of OCTN1/Octn1 in phenformin-induced mitochondrial toxicity
- Author(s)
  菊田奈津子、設楽悦久、則岡美咲、中道範隆、加藤将夫、堀江利治
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島県広島市
- Data Source
  KAKENHI-PROJECT-23790173
[Presentation] ミトコンドリア内への薬物取り込み機構およびその毒性発現への関与
- Author(s)
  設楽悦久、則岡美咲、菊田奈津子、藤野亮、中道範隆、加藤将夫、堀江利治
- Organizer
  日光シンポジウム
- Place of Presentation
  栃木県日光市
- Data Source
  KAKENHI-PROJECT-23790173
[Presentation] Uptake of organic anions in rat mitochondra isolated from different tissues
- Author(s)
  藤野亮、設楽悦久、堀江利治
- Organizer
  第5回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-23790173

1. HORIE Toshiharu (90120154)

# of Collaborated Projects: 4 results

# of Collaborated Products: 60 results
2. SEKINE Shuichi (70401007)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
3. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. HAYASHI Hiroyuki (00302612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HAYASHI Hisamitsu (10451858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MADEA Kazuya (00345258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKIKAWA Hajime (70197226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 桝渕泰宏 (10209455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤晃成 (30323405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大貫玲子 (70361607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHITARA Yoshihisa 設楽 悦久

設楽 悦久 シタラ ヨシヒサ

Research Projects

Research Products

Co-Researchers

Quantitative analysis of drugs induced BSEP inhibition and cholestatic hepatotoxicity

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薬剤による毒性発症に関わる因子としてのミトコンドリア内への担体介在性輸送Principal Investigator

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Molecular analysis of localization of biliary transporters in chronic hepatitis

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Mechanism of long-lasting inhibition of transporters as a mechanism of transporter-related drug-drug interactionsPrincipal Investigator

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Intrahepatic imaging and molecular analysis of MRP2 localization regulated by the intracellular redox status

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薬物投与によるトランスポーター機能変化の定量的解析および機序解明Principal Investigator

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Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters

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MRP2 mediated defense against oxidative stress in liver

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HMG-CoA還元酵素阻害薬と他剤併用時の薬物間相互作用のメカニズム解析Principal Investigator

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薬物トランスポーターを介した取り込み過程で生じる薬物間相互作用の定量的予測Principal Investigator

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[Book] Extrapolationod In vitro Metabolic and P-Glycoprotein-mediated Transport data to In vivo by Modeling and Simulations, in "Enzyme- and Transporter-Based drug-drug interactions"2010

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[Book] Web-Based Database as a Tool to examine drug-drug interactions involving transporters in Enzyme- and Transporter-Based drug-drug interactions"2010

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[Book] 薬物トランスポーター 活用ライブラリー(第3章2-(3)スタチン系高脂血症治療薬の薬物間相互作用に関わるトランスポーター)2010

Author(s)

Total Pages

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[Book] Extrapolationod In vitro Metabolic and P-Glycoprotein-mediated Transport data to In vivo by Modeling and Simulations, in "Enzyme- and Transporter-Based drug-drug interactions"2010

Author(s)

SHITARA Yoshihisa 設楽悦久

設楽悦久シタラヨシヒサ

[Book] 薬物トランスポーター活用ライブラリー(第3章2-(3)スタチン系高脂血症治療薬の薬物間相互作用に関わるトランスポーター)2010

[Book] 遺伝子医学MOOK7号最新創薬学2007-薬物動態特性の解析は創薬のキーワード-(杉山雄一編)第2章2-(5)輸送における薬物間相互作用pp.155-1622007