HAMADA KOZO 濱田耕造

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Hamada Kozo 濱田耕造

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Researcher Number	00311358
Other IDs
Affiliation (Current)	2025: 東邦大学, 理学部, 訪問研究員 2025: 近畿大学, 薬学部, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2022: 東邦大学, 理学部, 訪問研究員 2018: 近畿大学, 薬学部, 研究支援者 2015 – 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology Except Principal Investigator Integrative animal science
Keywords	Principal Investigator 認知症 / 小胞体 / カルシウム / タンパク質 / シグナル伝達 / 受容体 / カルシウムシグナリング / 老化 / 脳神経疾患 / 神経科学 … More / タウ / カルシウムチャネル / イオンチャネル / イノシトール三リン酸 / 細胞内シグナリング / チャネル / 細胞老化 / 細胞死 / 生理学 / αシヌクレイン / カルシウム(Ca2+) / 構造変化 / シヌクレイン / オートファジー / アロステリック / Ｘ線結晶構造解析 / クライオ電子顕微鏡 / X線結晶構造解析 / 受容体タンパク質 / ゲート機構 / アロステリック制御 / dementia / autophagy / endoplasmic reticulum / x-ray crystallography / second messenger / ion channel / calcium signaling / allostery … More Except Principal Investigator 膵外分泌機能 / ムスカリニックアセチルコリン受容体 / 光刺激 / ムスカリン作動性アセチルコリン受容体 / カルシウムシグナリング Less

Role of Ca2+ signaling at ER microdomains in dementiaPrincipal Investigator
- Principal Investigator
  
  濱田耕造
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Toho University
タンパク質老化と毒性機序における小胞体カルシウムの役割Principal Investigator
- Principal Investigator
  
  濱田耕造
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kindai University
  Institute of Physical and Chemical Research
Abnormal allostery in ER calcium channel involved in neurodegenerative diseasePrincipal Investigator
- Principal Investigator
  
  Hamada Kozo
- Project Period (FY)
  2015 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Toho University
  Kindai University
  Institute of Physical and Chemical Research
Investigation of the mechanism of the Ca2+ dependent exocrine pancreatic secretion by optogenetic control
- Principal Investigator
  
  Nakamura Kyoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Juntendo University
タウタンパク質老化と毒性機序における小胞体カルシウムの役割Principal Investigator
- Principal Investigator
  
  濱田耕造
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation Book

[Book] アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発2018
- Author(s)
  濱田耕造、御子柴克彦
- Total Pages
  460
- Publisher
  (株)エヌ・ティー・エス
- ISBN
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Book] 実験医学 2018年3月号2018
- Author(s)
  濱田耕造、御子柴克彦
- Total Pages
  145
- Publisher
  羊土社
- ISBN
  9784758125055
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Book] 実験医学 2018年3月号2018
- Author(s)
  濱田耕造、御子柴克彦
- Total Pages
  145
- Publisher
  羊土社
- ISBN
  9784758125055
- Data Source
  KAKENHI-PROJECT-15K06791
[Book] アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発2018
- Author(s)
  濱田　耕造、御子柴　克彦
- Total Pages
  460
- Publisher
  (株)エヌ・ティー・エス
- ISBN
- Data Source
  KAKENHI-PROJECT-15K06791
[Journal Article] A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors2022
- Author(s)
  Lavik Andrew R.、McColl Karen S.、Lemos Fernanda O.、Kerkhofs Martijn、Zhong Fei、Harr Michael、Schlatzer Daniela、Hamada Kozo、Mikoshiba Katsuhiko、Crea Francesco、Bultynck Geert、Bootman Martin D.、Parys Jan B.、Distelhorst Clark W.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1869 Issue: 4 Pages: 119206-119206
- DOI
  10.1016/j.bbamcr.2021.119206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-21K06379, KAKENHI-PROJECT-20K06864
[Journal Article] Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis2021
- Author(s)
  Rosa Nicolas、Ivanova Hristina、Wagner Larry E.、Kale Justin、La Rovere Rita、Welkenhuyzen Kirsten、Louros Nikolaos、Karamanou Spyridoula、Shabardina Victoria、Lemmens Irma、Vandermarliere Elien、Hamada Kozo、et al.
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 29 Issue: 4 Pages: 788-805
- DOI
  10.1038/s41418-021-00894-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-20K06864, KAKENHI-PROJECT-21K06379
[Journal Article] Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast2021
- Author(s)
  Kanda Yuki、Satoh Ryosuke、Takasaki Teruaki、Tomimoto Naofumi、Tsuchiya Kiko、Tsai Chun An、Tanaka Taemi、Kyomoto Shu、Hamada Kozo、Fujiwara Toshinobu、Sugiura Reiko
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Pages: 1-5
- DOI
  10.1242/jcs.250191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-20K06494, KAKENHI-PROJECT-19H03376, KAKENHI-PROJECT-20J15403, KAKENHI-PROJECT-21K06379
[Journal Article] Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells2020
- Author(s)
  Yue Lili、Wang Liuqing、Du Yangchun、Zhang Wei、Hamada Kozo、Matsumoto Yoshifumi、Jin Xi、Zhou Yandong、Mikoshiba Katsuhiko、Gill Donald L.、Han Shengcheng、Wang Youjun
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 2 Pages: 275-275
- DOI
  10.3390/cells9020275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-18K06538, KAKENHI-PROJECT-20K06864
[Journal Article] IP3Receptor Plasticity Underlying Diverse Functions2020
- Author(s)
  Hamada Kozo、Mikoshiba Katsuhiko
- Journal Title
  
  Annual Review of Physiology
  
  Volume: 82 Issue: 1 Pages: 151-176
- DOI
  10.1146/annurev-physiol-021119-034433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-20K06864
[Journal Article] Ouabain‐regulated phosphoproteome reveals molecular mechanisms for Na+, K+‐ATPase control of cell adhesion, proliferation, and survival2019
- Author(s)
  Panizza Elena、Zhang Liang、Fontana Jacopo Maria、Hamada Kozo、Svensson Daniel、Akkuratov Evgeny E.、Scott Lena、Mikoshiba Katsuhiko、Brismar Hjalmar、Lehti? Janne、Aperia Anita
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 9 Pages: 10193-10206
- DOI
  10.1096/fj.201900445r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06791
[Journal Article] Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output2019
- Author(s)
  Ivanova Hristina、Wagner Larry E.、Tanimura Akihiko、Vandermarliere Elien、Luyten Tomas、Welkenhuyzen Kirsten、Alzayady Kamil J.、Wang Liwei、Hamada Kozo、Mikoshiba Katsuhiko、De Smedt Humbert、Martens Lennart、Yule David I.、Parys Jan B.、Bultynck Geert
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 0 Issue: 19 Pages: 0-0
- DOI
  10.1007/s00018-019-03091-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05711, KAKENHI-PROJECT-15K06791, KAKENHI-PUBLICLY-18H04741
[Journal Article] Ca2+ signaling and spinocerebellar ataxia2018
- Author(s)
  Hisatsune Chihiro、Hamada Kozo、Mikoshiba Katsuhiko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1865 Issue: 11 Pages: 1733-1744
- DOI
  10.1016/j.bbamcr.2018.05.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06791, KAKENHI-PUBLICLY-17H05711
[Journal Article] New Insights into the Gating Mechanism of the IP3 Receptor2017
- Author(s)
  Hamada Kozo, Mikoshiba Katsuhiko
- Journal Title
  
  Messenger
  
  Volume: 6 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Journal Article] IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography2017
- Author(s)
  Hamada K, Miyatake H, Terauchi A, Mikoshiba K
- Journal Title
  
  PNAS (Proceedings of the National Academy of Sciences of the United States of America)
  
  Volume: 114(18) Issue: 18 Pages: 4661-4666
- DOI
  10.1073/pnas.1701420114
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01572, KAKENHI-PROJECT-15K06791, KAKENHI-PUBLICLY-17H05711, KAKENHI-PROJECT-25221002
[Journal Article] New Insights into the Gating Mechanism of the IP3 Receptor2017
- Author(s)
  Hamada Kozo、Mikoshiba Katsuhiko
- Journal Title
  
  Messenger
  
  Volume: 6 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06791
[Presentation] IP3-Mediated Gating Mechanism of IP3 Receptor2018
- Author(s)
  Hamada Kozo、Miyatake Hideyuki、Terauchi Akiko、Mikoshiba Katsuhiko
- Organizer
  Gordon Research Conference, CA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06791
[Presentation] IP3-Mediated Gating Mechanism of IP3 Receptor2018
- Author(s)
  Hamada Kozo [poster presenter], Miyatake Hideyuki, Terauchi Akiko, Mikoshiba Katsuhiko
- Organizer
  Gordon Research Conference, Ligand Recognition and Molecular Gating, March 4-9, 2018, Ventura, CA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography2017
- Author(s)
  Hamada Kozo [poster presenter], Miyatake Hideyuki, Terauchi Akiko, Mikoshiba Katsuhiko
- Organizer
  Gordon Research Conference, Calcium Signalling, June 18-23, 2017, Lucca, Italy
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] [Late-Breaking Topics] Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography2017
- Author(s)
  Hamada Kozo [oral presenter], Miyatake Hideyuki, Terauchi Akiko, Mikoshiba Katsuhiko
- Organizer
  Gordon Research Conference, Calcium Signalling, June 18-23, 2017, Lucca, Italy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] Gating mechanism of the brain-enriched IP3 receptor isoform revealed by mutagenesis and X-ray crystallography2017
- Author(s)
  濱田耕造、宮武秀行、寺内明子、御子柴克彦 [ポスター発表者]
- Organizer
  第40回日本神経科学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] IP3受容体の結晶構造からひもとくアロステリック機構と疾病メカニズム2017
- Author(s)
  濱田耕造、宮武秀行、寺内明子、御子柴克彦
- Organizer
  生命科学系学会合同年次大会（ConBio2017)
- Invited
- Data Source
  KAKENHI-PROJECT-15K06791
[Presentation] IP3受容体の結晶構造からひもとくアロステリック機構と疾病メカニズム2017
- Author(s)
  濱田耕造 [講演者]、宮武秀行、寺内明子、御子柴克彦
- Organizer
  生命科学系学会合同年次大会（ConBio2017)
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] IP3-Mediated Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography2017
- Author(s)
  Hamada Kozo, Miyatake Hideyuki, Terauchi Akiko, Mikoshiba Katsuhiko [ポスター発表者]
- Organizer
  Janelia Research Campus November 5-8, 2017　 Emerging Tools for Acquisition and Interpretation of Whole-Brain Functional Data
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] Gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography2017
- Author(s)
  濱田耕造、宮武秀行、寺内明子、御子柴克彦
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-15K06791
[Presentation] Gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography2017
- Author(s)
  濱田耕造 [ポスター発表者]、宮武秀行、寺内明子、御子柴克彦
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography2017
- Author(s)
  Hamada Kozo
- Organizer
  Gordon Research Conference, Lucca, Italy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06791
[Presentation] IP3受容体のゲート機構2017
- Author(s)
  濱田耕造
- Organizer
  大阪大学　蛋白研セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05711
[Presentation] IP3受容体のゲート機構2017
- Author(s)
  濱田耕造
- Organizer
  大阪大学　蛋白研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15K06791
[Presentation] Regulation of IP3 Receptor by Transglutaminase2015
- Author(s)
  濱田耕造、寺内明子、中村京子、肥後剛康、貫名信行、松本渚、久恒智博、中村健、御子柴克彦
- Organizer
  日本神経化学会大会
- Place of Presentation
  埼玉県大宮ソニックシティー
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PUBLICLY-15H01572
[Presentation] Regulation of IP3 Receptor by Transglutaminase2015
- Author(s)
  濱田耕造、寺内明子、中村京子、肥後剛康、貫名信行、松本渚、久恒智博、中村健、御子柴克彦
- Organizer
  日本神経化学会大会
- Place of Presentation
  埼玉県大宮ソニックシティー
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K06791

1. Nakamura Kyoko (90578858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAMADA KOZO 濱田 耕造

Hamada Kozo 濱田 耕造

Research Projects

Research Products

Co-Researchers

Role of Ca2+ signaling at ER microdomains in dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タンパク質老化と毒性機序における小胞体カルシウムの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Abnormal allostery in ER calcium channel involved in neurodegenerative diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of the Ca2+ dependent exocrine pancreatic secretion by optogenetic control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

タウタンパク質老化と毒性機序における小胞体カルシウムの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] アルツハイマー病 発症メカニズムと新規診断法・創薬・治療開発2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学 2018年3月号2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学 2018年3月号2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] アルツハイマー病 発症メカニズムと新規診断法・創薬・治療開発2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IP3Receptor Plasticity Underlying Diverse Functions2020

HAMADA KOZO 濱田耕造

Hamada Kozo 濱田耕造

[Book] アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発2018

[Book] アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発2018