OHNISHI Motoko 大西素子

… Alternative Names

Researcher Number	00312653
Affiliation (Current)	2022: 中部大学, 応用生物学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2018: 中部大学, 応用生物学部, 教授 2014: 中部大学, 公私立大学の部局等, 教授 2008 – 2010: Chubu University, 応用生物学部, 教授 2007: Chubu University, College of Biosecience and Biotechnology, Associate Professor 2002 – 2006: 中部大学, 応用生物学部, 助教授
Review Section/Research Field	Principal Investigator Applied biochemistry / Biomolecular chemistry Except Principal Investigator Applied biochemistry / Food science / Eating habits, studies on eating habits / Natural medicines / 応用微生物学・応用生物化学 / Applied microbiology
Keywords	Principal Investigator 破骨細胞 / RANKL / プロテインホスファターゼ / シグナル伝達 / 破骨細胞分化因子 / 発生・分化 / 酵素 / 生理活性 / 細胞・組織 / プロテインホスファターゼ2C … More Except Principal Investigator 破骨細胞 / 骨吸収 / 骨粗鬆症 / 骨吸収抑制剤 / デストラクシン / osteoclast / bone resorption / osteoporosis / reveromycin A / リベロマイシン / 微生物代謝産物 / 骨芽細胞 / 骨形成 / 天然化合物 / アポトーシス / 機能発現 / destruxins / 代謝産物 / EGCG / 歯周病 / harmine / honokiol / acerogenin / 酸味受容体 / 酸味抑制 / 酸味増強 / 味覚修飾 / パッチクランプ法 / 電気生理学的測定 / 酸味修飾 / ASIC / PKD / 電気生理学的アッセイ / アフリカツメガエル / 電気生理学的手法 / 微生物生産 / 骨代謝 / 骨形成促進剤 / 天然活性物質 / 作用機構 / アポトーシツ / 生存 / 分化 / 機能 / 活性化 / apoptosis / destruxin / microbial metabolite / action mechanism / メバスタチン / 細胞死 / 阻害 / タンパク質合成 / tRNA / 酸性環境 / 選択作用 / mevastatin / cell death / inhibition / コンパクチン / コプチシン / ベルベリン / ベロマイシンA / アルカロイド / ベロマイシン / 細胞骨格 / 骨密度 / compactin / coptisine / berberine / リベロマイシンA / クルクミン / ネポジン / トリフェニルスズ / 植物代謝産物 / フラボノイド / 有機スズ化合物 / ケルセチン / ルテオリン / curcumin / nepodin / triphenyltin Less

Chemical biological studiesPrincipal Investigator
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Chubu University
Biological activities and drug development of natural compounds with bone-resorbing and bone-forming properties during bone metabolism
- Principal Investigator
  
  WOO Je-Tae
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Natural medicines
- Research Institution
  Chubu University
Specification of sour taste receptior in human level by sour taste modifier and analysis of structiral corerationship
- Principal Investigator
  
  TSUKAMOTO Yoshinori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Chubu University
Regulation of osteoclastogenesis by protein phosphatase 2CPrincipal Investigator
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
Effectiveness studies of functional food components forosteoporosis prevention and improvement on cells, bone tissues and animals
- Principal Investigator
  
  WOO Jetae
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Chubu University
Supperession of Osteoclast Differentiation by Protein Phosphatase 2CPrincipal Investigator
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
The studies of action mechanism and pharmacological effect of anti-resorptive compounds that target osteocasts.
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
A Search and their action mode of microbial bioactive compounds that inhibit osteoclastic Bone Resorption.
- Principal Investigator
  
  WOO Je Tae
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Chubu University
A role of protein phosphatase 2C on osteoclast differentiation and activationPrincipal Investigator
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
Effects of Low Molecular Weight Compounds on Osteoclastic Bone Resorption in vivo and in vitro.
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
Studies on action mechanism of microbial metabolites that specifically inhibit osteoclastic bone resorption.
- Principal Investigator
  
  WOO Je-tae
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Chubu University

All 2019 2018 2017 2016 2015 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Patent

[Journal Article] A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice2019
- Author(s)
  Ishii Naoki、Homma Takujiro、Watanabe Ren、Kimura Naoko、Ohnishi Motoko、Kobayashi Takayasu、Fujii Junichi
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 19 Pages: 5353-5360
- DOI
  10.3892/mmr.2019.10194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-18K06948, KAKENHI-PROJECT-19K09016, KAKENHI-PROJECT-17K19316
[Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019
- Author(s)
  Shimizu Eisaku、Koshino Hiroyuki、Noro Aoi、Maruyama Miku、Shimoda Nozomu、Uesugi Shota、Ohnishi Motoko、Kimura Ken-ichi
- Journal Title
  
  Fitoterapia
  
  Volume: 134 Pages: 290-296
- DOI
  10.1016/j.fitote.2019.02.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-19K14046
[Journal Article] 6-および7-ホスホノメチルナフタレン-1-カルボン酸の化学合成2018
- Author(s)
  河村麻希，大西素子，堤内　要
- Journal Title
  
  生物機能開発研究所紀要
  
  Volume: 18
- NAID
  120006521134
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01810
[Journal Article] Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.2016
- Author(s)
  Kusano R, Fujita K, Shinoda Y, Nagaura Y, Kiyonari H, Abe T, Watanabe T, Matsui Y, Fukaya M, Sakagami H, Sato T, Funahashi JI, Ohnishi M, Tamura S, Kobayashi T.
- Journal Title
  
  FEBS Lett.
  
  Volume: 590 Pages: 3606-3615
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01810
[Journal Article] 植物由来のプロテインホスファターゼ2C活性制御物質2010
- Author(s)
  油井信弘,大西素子,木村賢一
- Journal Title
  
  バイオサイエンスインダストリー 68(4)
  
  Pages: 256-256
- NAID
  10026883285
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Sanguinarine as a Potent and Specific Inhibitor of Protein Phosphatase 2C in Vitro and Induces Apoptosis via Phosphorylation of p38 in HL60 Cells.2010
- Author(s)
  Aburai N, Yoshida M, Ohnishi M, Kimura K
- Journal Title
  
  Biosci Biotechnol Biochem. 74(3)
  
  Pages: 548-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Pisiferdiol and pisiferic acid isolated from Chamaecyparispisifera activate protein phosphatase2C in vitro and induce caspase-3/7-dependentapoptosis via dephosphorylation of Bad in HL60 cells.2010
- Author(s)
  Aburai N., Yoshida M., Ohnishi M., Kimura K.
- Journal Title
  
  Phytomedicine. 17(10)
  
  Pages: 782-788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] 2007 May. Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in HepG22007
- Author(s)
  Oishi Y, Ohnishi M, Kobayashi-Hattori K, Takita T, Noguchi T
- Journal Title
  
  Biosci Biotechnol Biochem. 71(5)
  
  Pages: 1334-1337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380077
[Journal Article] 2007 Jul. Disruption of the mouse protein Ser/Thr phosphatase 2Cbeta gene leads to early pre-implantation lethality2007
- Author(s)
  Sasaki M, Ohnishi M, Tashiro F, Niwa H, Suzuki A, Miyazaki J, Kobayashi T, Tamura S.
- Journal Title
  
  Mech Dev 124(6)
  
  Pages: 489-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380077
[Journal Article] プロテインホスファターゼ2Cα阻害物質の探索の試み2006
- Author(s)
  大西素子
- Journal Title
  
  中部大学生物機能開発研究所紀要 6
  
  Pages: 53-65
- NAID
  120006518367
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580096
[Journal Article] Screening of inhibitors of protein phosphatse 2C alpha.2006
- Author(s)
  Motoko Ohnishi
- Journal Title
  
  Annual Report of Research Institute for Biological Function 6
  
  Pages: 53-65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580096
[Journal Article] プロテインホスファターゼ2Cα阻害物質の探索の試み2006
- Author(s)
  大西素子他
- Journal Title
  
  中部大学生物機能開発研究所紀要 6
  
  Pages: 53-65
- NAID
  120006518367
- Data Source
  KAKENHI-PROJECT-18580096
[Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006
- Author(s)
  Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H, N.Udagawa, In-Sun Lee, Motoko Ohnishi, Hiromi Hagiwara, Kazuo Nagai
- Journal Title
  
  Eur J Pharmacol. 534
  
  Pages: 55-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Nonradiioactive assay of protein Ser/Thr phosphatase 2C2005
- Author(s)
  Ohnishi M
- Journal Title
  
  Annual report of research institute for biological function 5
  
  Pages: 37-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580078
[Journal Article] プロテインセリン/スレオニンホスファターゼ2Cの非RI活性測定法2005
- Author(s)
  大西素子他
- Journal Title
  
  中部大学生物機能開発研究所紀要 5
  
  Pages: 37-40
- NAID
  110004627646
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580078
[Journal Article] Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts.2004
- Author(s)
  Woo, J.-T., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, L.-S., Ohnishi, M., Hagiwara, H., Nagai, K.
- Journal Title
  
  Biol. Pharm. Bull 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts.2004
- Author(s)
  J-T Woo, H Nakagawa, M Notoya, T Yonezawa, M Ohnishi, K.Nagai
- Journal Title
  
  Biological Pharm.Bull 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] The calcineurin/ NFAT signaling pathway regulates osteoclastogenesis in RAW264.7 cells.2004
- Author(s)
  Hirotani H, Tuohy NA, Woo JT, Stern PH, Clipstone NA, N.Udagawa, In-Sun Lee, Motoko Ohnishi, Hiromi Hagiwara, Kazuo.Nagai
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 13984-13992
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts.2004
- Author(s)
  J -T Woo, H Nakagawa, M Notoya, T Yonezawa, M Ohnishi, K.Nagai
- Journal Title
  
  Biological Pharm.Bull. 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts2004
- Author(s)
  Woo, J.-T., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, I.-S., Ohnishi, M., Hagiwara, H., Nagai, K.
- Journal Title
  
  Biol.Pharm.Bull. 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Patent] 骨吸収抑制剤2008
- Inventor(s)
  大西素子, 木村賢一, 禹済泰, 永井和夫
- Industrial Property Number
  2008-219666
- Filing Date
  2008
- Data Source
  KAKENHI-PROJECT-19380077
[Patent] 破骨細胞分化抑制剤2008
- Inventor(s)
  大西素子、永井和夫、禹済泰、木村賢一
- Industrial Property Rights Holder
  学校法人中部大学、国立大学法人岩手大学
- Industrial Property Number
  2008-219666
- Filing Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-20580105
[Patent] 骨吸収抑制剤2008
- Inventor(s)
  大西素子, 木村賢一, 萬済泰, 永井和夫.
- Industrial Property Rights Holder
  中部大学, 岩手大学
- Industrial Property Number
  2008-219666
- Filing Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-20580105
[Patent] 特許権2007
- Inventor(s)
  木村賢一/油井信弘/大西素子
- Industrial Property Rights Holder
  岩手大学/中部大学
- Industrial Property Number
  2007-053142
- Filing Date
  2007-03-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580096
[Presentation] マルトビオン酸は卵巣摘出マウスの骨量減少を抑制する2019
- Author(s)
  西尾彩花, 中村保奈美, 中川大, 渡辺章夫, 米澤貴之, 禹　済泰, 末廣大樹, 阿部秀飛, 深見健, 大西素子
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] 種々のアリールセラニル基を有する化合物の合成とプロテインホスファターゼ阻害能2018
- Author(s)
  澤本佳佑，神谷憲児，沢柳大，依藤知洋，饒村修，加藤友佳，大西素子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] アリールジセレニドの合成とプロテインホスファターゼ阻害能2018
- Author(s)
  澤本佳佑・饒村修・後藤保・大西素子
- Organizer
  第49回中部化学関係学協会支部連合秋期大会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] 卵巣切除マウスにおけるマルトビオン酸の骨密度改善効果2018
- Author(s)
  西尾彩花, 鵜飼容子, 山口青夏, 中川大, 渡辺章夫, 米澤貴之, 禹　済泰, 末廣大樹, 阿部秀飛, 深見健, 大西素子
- Organizer
  食品科学工学会第65回大会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] マルトビオン酸は破骨細胞分化を抑制する2018
- Author(s)
  西尾彩花，鵜飼容子，山口青夏，末廣大樹，渡辺章夫, 米澤貴之, 禹済泰，阿部秀飛，深見健，大西素子
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] PPM1 活性化物質は成熟脂肪細胞における脂肪滴の蓄積を抑制する2017
- Author(s)
  鵜飼容子、佐竹一紘、中川大、木村賢一、大西素子
- Organizer
  日本農芸化学会2017年度大
- Place of Presentation
  京都女子大学（京都府，京都市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] プロテインSer/Thrホスファターゼ活性化物質の脂肪細胞における脂肪蓄積抑制効果2017
- Author(s)
  西尾彩花，鵜飼容子，佐竹一紘，中川大，木村賢一，大西素子
- Organizer
  第81回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] マルトビオン酸の破骨細胞分化抑制効果2017
- Author(s)
  西尾彩花，鵜飼容子，山口青夏，末廣大樹，阿部秀飛，深見健，大西素子
- Organizer
  第30回日本動物細胞工学会2017年度大会
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] 癌遺伝子産物 PPM1D を阻害する低分子化合物2016
- Author(s)
  岩崎祐太，青山友果，鵜飼武寛，鵜飼容子，饒村修，大西素子
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] 抗CD98依存性細胞融合に対するホスファターゼ阻害剤の効果2016
- Author(s)
  鵜飼容子，青山友果，伊藤守弘，禹済泰，中川大，大西素子
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] プロテインホスファターゼ阻害剤による抗CD98抗体依存性細胞融合の阻害2016
- Author(s)
  鵜飼容子, 青山友果, 伊藤守弘, 大西素子
- Organizer
  第80回日本生化学会中部支部例会
- Place of Presentation
  三重大学（三重県，津）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] プロテインSer/ThrホスファターゼWip1阻害剤の探索と生体基質を用いた阻害効果の解析2016
- Author(s)
  岩崎祐太，青山友果，鵜飼武寛，饒村修，大西素子
- Organizer
  第7回日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  自然科学研究機構（愛知県岡崎市）
- Year and Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] 抗CD98抗体依存性細胞融合阻害物質による破骨細胞分化の抑制2016
- Author(s)
  鵜飼容子, 青山友果, 伊藤守弘, 大西素子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県，仙台市）
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] 抗CD98依存性細胞融合阻害物質の探索2015
- Author(s)
  鵜飼容子，伊藤守弘，禹済泰，中川大，大西素子
- Organizer
  第10回トランスポーター研究会年会
- Place of Presentation
  慶応大学（東京都港区）
- Year and Date
  2015-06-21
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] プロテインSer/ThrホスファターゼWip1阻害剤の同定とその性質2015
- Author(s)
  鵜飼容子，青山友果，鵜飼武寛，饒村修，大西素子
- Organizer
  第28回日本動物細胞工学会2015年度大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K01810
[Presentation] プロテインホスファターゼ2C活性化化合物の破骨細胞分化抑制機構の解析2009
- Author(s)
  吉田真実、倉知建始、油井信弘、木村賢一、長谷川森一、池原強、禹済泰、永井和夫、大西素子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] プロテインホスフアターゼ2C活性化化合物の破骨細胞分化抑制機構の解析2009
- Author(s)
  吉田真実, 倉知建始, 油井信弘, 木村賢一, 長谷川森一, 池原強, 禹済泰, 永井和夫, 大西素子
- Organizer
  日本農芸化学会2009年年度大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] PP2C活性化作用を有する化合物の構造と機能性2008
- Author(s)
  油井信弘、斉藤圭一、吉田真実、宮川都吉、大西素子、木村賢一
- Organizer
  日本ケミカルバイオロジー研究会第3回年会
- Place of Presentation
  東京都・学術総合センター
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] Nov. Suppression of osteoclast differentiation by pisiferdiol, an activator of protein phosphatase 2C2008
- Author(s)
  Mami Yoshida, Nobuhiro Aburai, Ken-ichi Kimura, Shinichi Hasegawa, Tsuyoshi Ikehara, Je-Tae Woo, Kazuo Nagai, Motoko Ohnishi
- Organizer
  8th International Conference on Protein Phosphatases
- Place of Presentation
  群馬県・前橋テルサ
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] プロテインホスファターゼ2C活性化化合物による破骨細胞分化の抑制2008
- Author(s)
  吉田真実、油井信弘、木村賢一、池原強、禹済泰、永井和夫、大西素子
- Organizer
  日本分子生物学会第31回年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] Pisiferdiolのプロテインホスファターゼ2C活性化作用2008
- Author(s)
  吉田真実、油井信弘、木村賢一、池原強、禹済泰、永井和夫、大西素子
- Organizer
  日本農芸化学会
- Place of Presentation
  愛知県・名城大学
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] Pisiferdiolのプロテインホスファターゼ2C活性化作用2008
- Author(s)
  吉田真実、油井信弘、木村賢一、池原強、禹済泰、永井和夫、大西素子
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  愛知県・名城大学
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] The role of protein phosphatases in osteoclastogenesis.2007
- Author(s)
  Motoko Ohnishi
- Organizer
  150th Regular Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry, Chubu
- Place of Presentation
  Aich
- Year and Date
  2007-09-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580096
[Presentation] 破骨細胞分化におけるプロテインホスファターゼの役割2007
- Author(s)
  大西素子
- Organizer
  2007年度日本農芸化学会関西支部・中部支部合同大会シンポジウム
- Place of Presentation
  愛知県・中部大学
- Year and Date
  2007-09-22
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] 破骨細胞分化におけるプロテインホスファターゼの役割2007
- Author(s)
  大西素子
- Organizer
  日本農芸化学会関西支部・中部支部合同大会シンポジウム
- Place of Presentation
  中部大学(愛知県)
- Year and Date
  2007-09-21
- Data Source
  KAKENHI-PROJECT-18580096
[Presentation] 破骨細胞分化におけるプロテインホスファターゼの役割2007
- Author(s)
  大西素子
- Organizer
  2007年度日本農芸化学会関西支部・中部支部合同大会シンポジウム
- Place of Presentation
  愛知
- Year and Date
  2007-09-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580096
[Presentation] Pisiferdiol and Pisiferic Acid Isolated from Chamaecyparis pisifera Activate Protein Phosphatase 2C In vitro and In vivo2007
- Author(s)
  Nobuhiro Aburai, Motoko Ohnishi, and Ken-ichi Kimura
- Organizer
  The 4th Takeda Science Foundation Symposium on Pharmasciences
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-19380077
[Presentation] RANKL/RANKシグナル伝達経路におけるPP2CβおよびPP2Cεの役割2007
- Author(s)
  三好信寛、佐々木一洋、小林孝安、禹済泰、永井和夫、田村眞理^1、大西素子
- Organizer
  第3回プロテインホスファターゼ研究会学術集会
- Place of Presentation
  三重大学
- Data Source
  KAKENHI-PROJECT-19380077

1. WOO Jetae (20272693)

# of Collaborated Projects: 10 results

# of Collaborated Products: 18 results
2. NAGAI Kazuo (00011974)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
3. CHA Byungyoon (00410663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MINAMI Motoyasu (90340207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TSUKAMOTO Yoshinori (60592079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. UKAWA Shinya (20326135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TEI Yuichi (30345053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OTA Masato (70313228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 堤内要 (50329851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 石田康行 (70273266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中川大 (40397039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 林宣宏 (80267955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 饒村修 (20365175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. KIMURA Naoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. KIMURA Ken-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 藤井順逸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 小林孝安

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 越野広雪

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHNISHI Motoko 大西 素子

ONISHI Motoko 大西 素子

Research Projects

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Co-Researchers

Chemical biological studiesPrincipal Investigator

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Biological activities and drug development of natural compounds with bone-resorbing and bone-forming properties during bone metabolism

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Specification of sour taste receptior in human level by sour taste modifier and analysis of structiral corerationship

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Regulation of osteoclastogenesis by protein phosphatase 2CPrincipal Investigator

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Effectiveness studies of functional food components forosteoporosis prevention and improvement on cells, bone tissues and animals

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Supperession of Osteoclast Differentiation by Protein Phosphatase 2CPrincipal Investigator

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The studies of action mechanism and pharmacological effect of anti-resorptive compounds that target osteocasts.

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A Search and their action mode of microbial bioactive compounds that inhibit osteoclastic Bone Resorption.

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A role of protein phosphatase 2C on osteoclast differentiation and activationPrincipal Investigator

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Effects of Low Molecular Weight Compounds on Osteoclastic Bone Resorption in vivo and in vitro.

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Studies on action mechanism of microbial metabolites that specifically inhibit osteoclastic bone resorption.

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[Journal Article] A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice2019

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[Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019

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OHNISHI Motoko 大西素子

ONISHI Motoko 大西素子