KOYANAGI Masamichi 小柳雅孔

… Alternative Names

小柳雅孔コヤナギマサミチ

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Researcher Number	00325474
Affiliation (based on the past Project Information) *help	2011 – 2017: 九州大学, 大学病院, 助教 2014: 九州大学病院別府病院, 内科, 助教 2013: 九州大学病院, 別府病院, 助教 2001 – 2002: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator General internal medicine(including psychosomatic medicine) / Circulatory organs internal medicine / Circulatory organs internal medicine / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator 循環器内科学 / 国際情報交換（ドイツ） / Wntシグナル / エピジェネティック / 再生医療 / エピジェネテックス / 心血管リモデリング / アンジオテンシン変換酵素 / 動脈硬化 / 一酸化窒素 / MCP-1 / 単球・マクロファージ … More Except Principal Investigator … More MMP / PPAR-r / サイトカイン / テロメア / 老化 / DNA / 温熱 / 生物学的老化 / NFκ-B / Cytokines / Brain Natriuretic Peptide / Cardiac Remodeling / TIMP / TNF-alpha / 心筋細胞 / 低酸素 / マトリックスメタロプロテアーゼ / NFk-b / BNP / 心筋リモデリング / 近赤外線レーザー / 心臓局所温熱 / トランスジェニックマウス / ナノテクノロジー / 循環器 / 温熱療法 / 心不全 / 金ナノロッド / 血管内皮細胞 / 白血球 / 環状DNA Less

The development of aging parameters by serum telomere DNA analysis
- Principal Investigator
  
  Maeda Toyoki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyushu University
Targeted heart hyperthermia for heart failure using gold nano-rod
- Principal Investigator
  
  HIGUCHI Yoshihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
The evaluation of genomic aging by quantifying telomeric circular DNA in peripheral leukocytes of patients with chronic disease.
- Principal Investigator
  
  MAEDA Toyoki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kyushu University
Epigenetic control of cardiac gene expressions by non-canonical WntsPrincipal Investigator
- Principal Investigator
  
  KOYANAGI Masamichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Matrix Degradative Enzyme Activities on Cardiac Remodeling in Heart Failure
- Principal Investigator
  
  MAKINO Naoki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
動脈硬化の分子療法(抗ケモカイン療法)の開発Principal Investigator
- Principal Investigator
  
  小柳雅孔
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University

All 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] Title; Circulating progenitor cells a part of"HEART REGENERATION Stem Cells and Beyond"2012
- Author(s)
  Masamichi Koyanagi and Stefanie Dimmeler
- Publisher
  Pub.
- Data Source
  KAKENHI-PROJECT-23591083
[Journal Article] FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction.2016
- Author(s)
  Makino N, Oyama J, Maeda T, Koyanagi M, Higuchi Y, Shimokawa I, Mori N, Furuyama T.
- Journal Title
  
  Mol Cell Biochem.
  
  Volume: 412 Issue: 1-2 Pages: 119-130
- DOI
  10.1007/s11010-015-2615-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08142, KAKENHI-PROJECT-15H04682, KAKENHI-PROJECT-15K08919, KAKENHI-PROJECT-15K14352
[Journal Article] Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts.2015
- Author(s)
  Makino N, Oyama J, Maeda T, Koyanagi M, Higuchi Y, Tsuchida K.
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 403 Issue: 1-2 Pages: 1-11
- DOI
  10.1007/s11010-015-2327-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08919
[Journal Article] X-irradiation alters the telomerase activity and the telomere length distribution of cultured human vascular endothelial cells2014
- Author(s)
  Toyoki Maeda, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino
- Journal Title
  
  Appl Cell Biol
  
  Volume: 3
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] X-irradiation alters the telomerase activity and the telomere length distribution of cultured human vascular endothelial cells.2014
- Author(s)
  Toyoki Maeda1, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino.
- Journal Title
  
  Appl Cell Biol
  
  Volume: 3 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Vascular endothelial cell surviving through under prolonged elevated temperature shows persistent or transient up-regulation of telomerase and stress-associated proteins.2014
- Author(s)
  Toyoki Maeda1, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino.
- Journal Title
  
  Appl Cell Biol
  
  Volume: 3 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Vascular endothelial cell surviving through under prolonged elevated temperature shows persistent or transient up-regulation of telomerase and stress-associated proteins2014
- Author(s)
  Toyoki Maeda, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino
- Journal Title
  
  Appl Cell Biol
  
  Volume: 2
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Alterations in the telomere length distribution and the subtelomeric methylation status in human vascular endothelial cells under elevated temperature in culture condition2013
- Author(s)
  Maeda T, G. Jing-Zhi, Koyanagi M Makino N
- Journal Title
  
  Aging Clin Exp Res
  
  Volume: 25 Pages: 231-238
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Alterations in the telomere length distribution and the subtelomeric methylation status in human vascular endothelial cells under elevated temperature in culture condition.2013
- Author(s)
  Maeda T, Guan JZ, Koyanagi M, Makino N.
- Journal Title
  
  Aging Clin Exp Res.
  
  Volume: 25 Issue: 3 Pages: 231-238
- DOI
  10.1007/s40520-013-0045-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590885, KAKENHI-PROJECT-23591083
[Journal Article] Telomerase activity and telomere length distribution in vascular endothelial cell in a short-term culture under the presence of hydrogen peroxide2013
- Author(s)
  Maeda T, Jing-Zhi Guan, Koyanagi M, Makino N
- Journal Title
  
  Geriatrics and Gerontology International
  
  Volume: 13 Pages: 774-782
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Telomerase activity and telomere length distribution in vascular endothelial cells in a short-term culture under the presence of hydrogen peroxide.2013
- Author(s)
  Maeda T, Guan JZ, Koyanagi M, Makino N.
- Journal Title
  
  Geriatr Gerontol Int.
  
  Volume: 13 Issue: 3 Pages: 774-782
- DOI
  10.1111/j.1447-0594.2012.00936.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Acute myocardial infarction activates progenitor cells and increases Wnt signaling in the bone marrow2012
- Author(s)
  Assmus B, Iwasaki M, Schächinger V, Roexe T, Koyanagi M, Iekushi K, Xu Q, Tonn T, Seifried E, Liebner S, Kranert WT, Gruenwald F, Dimmeler S, Zeiher AM
- Journal Title
  
  Eur Heart J
  
  Volume: 33(15) Issue: 15 Pages: 1911-9
- DOI
  10.1093/eurheartj/ehr388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591083
[Journal Article] The gender-related alterations in the telomere length and subtelomeric methylation status in patients with Parkinson's disease2012
- Author(s)
  Maeda T, Jing-Zhi Guan, Koyanagi M, Makino N
- Journal Title
  
  Ageing Res
  
  Volume: 4 Pages: 61-66
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease.2012
- Author(s)
  Maeda T, Guan JZ, Koyanagi M, Higuchi Y, Makino N.
- Journal Title
  
  Journal of Neurogenetics
  
  Volume: 26 Issue: 2 Pages: 245-251
- DOI
  10.3109/01677063.2011.651665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590885, KAKENHI-PROJECT-23591083
[Journal Article] Upregulation of anticoagulant proteins, protein S and tissue factor pathway inhibitor, in the mouse myocardium with cardio-specific TNF-alpha overexpression2012
- Author(s)
  Higuchi Y, Kubota T, Koyanagi M, Maeda T, Feldman AM, Makino N.
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 302(11) Issue: 11 Pages: H2352-H2362
- DOI
  10.1152/ajpheart.01026.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591083, KAKENHI-PROJECT-24591098
[Journal Article] Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease2012
- Author(s)
  Toyoki Maeda, Jing Zhi Guan, Masamichi Koyanagi, Yoshihiro Higuchi, Naoki Makino
- Journal Title
  
  Neurogenetics
  
  Volume: 26 Pages: 245-251
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Upregulation of Anticoagulant Proteins, Protein S and Tissue Factor Pathway Inhibitor, in the Mouse Myocardium with Cardio-Specific TNF- x03B1; Overexpression2012
- Author(s)
  Yosihiro Higuchi, Masamichi Koyanagi, Toru Kubota, Toyoki Maeda, Arthur Feldman, Naoki Makino
- Journal Title
  
  Am J Physiol-Heart Circ Physiol
  
  Volume: 302
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] Hepatocyte Growth Factor Induces a Proangiogenic Phenotype and Mobilizes Endothelial Progenitor Cells by Activating Nox22011
- Author(s)
  Schroder, K; Schutz, S; Schloffel, I; Batz, S; Takac, I; Weissmann, N; Michaelis, UR; Koyanagi, M; Brandes,RP
- Journal Title
  
  ANTIOXIDANTS & REDOX SIGNALING
  
  Volume: 15巻4号 Issue: 4 Pages: 915-923
- DOI
  10.1089/ars.2010.3533
- Data Source
  KAKENHI-PROJECT-23591083
[Journal Article] Epigenetic Regulation of Endothelial Lineage Committed Genes in Pro-Angiogenic Hematopoietic and Endothelial Progenitor Cells2011
- Author(s)
  Ohtani, K; Vlachojannis, GJ; Koyanagi, M et al.
- Journal Title
  
  CIRCULATION RESEARCH
  
  Volume: 109巻11号 Issue: 11 Pages: 1219-1229
- DOI
  10.1161/circresaha.111.247304
- Data Source
  KAKENHI-PROJECT-23591083
[Journal Article] Epigenetic repression of endothelial lineage committed genes in pro- angiogenic hematopoietic progenitor cells2011
- Author(s)
  Ohtani K, Vlachojannis GJ, Koyanagi M, Boeckel JN, Urbich C, Marquez VE, Zeiher AM, & Dimmeler S
- Journal Title
  
  Circ Res
  
  Volume: 109(11) Pages: 1219-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591083
[Journal Article] 種々の臨床検査値と末梢血白血球テロメア関連パラメータとの連関の解析2011
- Author(s)
  前田豊樹,小柳雅孔,尾山純一,樋口義洋,牧野直樹
- Journal Title
  
  適応医学
  
  Volume: 14 Pages: 50-59
- Data Source
  KAKENHI-PROJECT-23590885
[Journal Article] 種々の臨床検査値と末梢血白血球テロメア関連パラメータとの連関の解析.2011
- Author(s)
  前田豊樹,小柳雅孔,尾山純一,樋口義洋,牧野直樹
- Journal Title
  
  適応医学
  
  Volume: 14 Pages: 50-59
- Data Source
  KAKENHI-PROJECT-23590885
[Presentation] Thrombomodulin Alpha Improved the Cardiac Function but not Hypertrophy in a Transgenic Mouse Model of Inflammatory Cardiomyopathy2013
- Author(s)
  Higuchi Y, Koyanagi M, Kubota T, Feldman AM, and Makino N.
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24591098
[Presentation] Epigenetic control of stem cell function2012
- Author(s)
  Masamichi Koyanagi
- Organizer
  AHA Scientific Sessions
- Place of Presentation
  Los Angels, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23591083
[Presentation] Title;Epigenetic control of stem cell function2012
- Author(s)
  Masamichi Koyanagi
- Organizer
  AHA Scientific Sessions
- Place of Presentation
  Los Angels, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23591083
[Presentation] Wnt5a increases histone lysine demethylases and induces epigenetic remodeling2011
- Author(s)
  Masamichi Koyanagi
- Organizer
  European Epigenomics & Stem Cells-2011 Meetings(招待講演)
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23591083
[Presentation] Title;Wnt5a increases histone lysine demethylases and induces epigenetic remodeling2011
- Author(s)
  Masamichi Koyanagi
- Organizer
  European Epigenomics & Stem Cells-2011 Meetings
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23591083

1. MAEDA Toyoki (30264112)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. MAKINO Naoki (60157170)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. NIIDOME Takuro (20264210)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HIGUCHI Yoshihiro (40404032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. OYAMA Junich (30359939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 門上俊明 (40335980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 堀内孝彦 (90219212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TSUCHIDA Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 稲垣忍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 古山達雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOYANAGI Masamichi 小柳 雅孔

小柳 雅孔 コヤナギ マサミチ

Research Projects

Research Products

Co-Researchers

The development of aging parameters by serum telomere DNA analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeted heart hyperthermia for heart failure using gold nano-rod

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The evaluation of genomic aging by quantifying telomeric circular DNA in peripheral leukocytes of patients with chronic disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetic control of cardiac gene expressions by non-canonical WntsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Matrix Degradative Enzyme Activities on Cardiac Remodeling in Heart Failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動脈硬化の分子療法(抗ケモカイン療法)の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Title; Circulating progenitor cells a part of"HEART REGENERATION Stem Cells and Beyond"2012

Author(s)

Publisher

Data Source

[Journal Article] FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] X-irradiation alters the telomerase activity and the telomere length distribution of cultured human vascular endothelial cells2014

Author(s)

Journal Title

Data Source

[Journal Article] X-irradiation alters the telomerase activity and the telomere length distribution of cultured human vascular endothelial cells.2014

Author(s)

Journal Title

Data Source

[Journal Article] Vascular endothelial cell surviving through under prolonged elevated temperature shows persistent or transient up-regulation of telomerase and stress-associated proteins.2014

Author(s)

Journal Title

Data Source

[Journal Article] Vascular endothelial cell surviving through under prolonged elevated temperature shows persistent or transient up-regulation of telomerase and stress-associated proteins2014

Author(s)

Journal Title

Data Source

[Journal Article] Alterations in the telomere length distribution and the subtelomeric methylation status in human vascular endothelial cells under elevated temperature in culture condition2013

Author(s)

Journal Title

Data Source

[Journal Article] Alterations in the telomere length distribution and the subtelomeric methylation status in human vascular endothelial cells under elevated temperature in culture condition.2013

Author(s)

Journal Title

DOI

Data Source

KOYANAGI Masamichi 小柳雅孔

小柳雅孔コヤナギマサミチ