SARAI Nobuaki 皿井伸明

Researcher Number	00335259
Other IDs
Affiliation (based on the past Project Information) *help	2005 – 2007: Kyoto University, Graduate School of Medicine, Lecture, 医学研究科, 科学技術振興講師 2005: 京都大学, 医学研究科ナノメディシン融合教育ユニット, 科学技術振興講師 2003 – 2004: 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science Except Principal Investigator General physiology
Keywords	Principal Investigator 生体シミュレーション / 心筋細胞モデル / 最適化 / simBio / 薬物作用 / 心筋細胞数理モデル Except Principal Investigator NADH / Ca^<2+> / simulation / mitochondria … More / cardiac myocyte / カルシウム / 心臓 / 興奮-収縮連関 / カルシウムイオン / シミュレーション / ミトコンドリア / 心筋細胞 Less

心筋シミュレータを用いた定量的な薬効予測システムの研究Principal Investigator
- Principal Investigator
  
  皿井伸明
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kyoto University
Study of energy metabolism-function coupling in cardiac myocyte
- Principal Investigator
  
  NOMA Akinori
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General physiology
- Research Institution
  Kyoto University

All 2007 2006 2005 2004 2003

All Journal Article Presentation Book Patent

[Book] simBio 心筋細胞のコンピュータ・シミュレーション2006
- Author(s)
  皿井伸明編著
- Total Pages
  220
- Publisher
  京都通信社
- Data Source
  KAKENHI-PROJECT-17700393
[Book] 心臓のフィジオーム : 電気生理現象のシミュレーション-分子から臓器まで(森北出版株式会社)(岡本良夫編著)2003
- Author(s)
  野間昭典, 松岡達, 皿井伸明
- Publisher
  包括的心筋細胞モデル(Kyoto model)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Book] 心臓のフィジオーム : 電気生理現象のシミュレーション-分子から臓器まで(森北出版株式会社)(岡本良夫編著)2003
- Author(s)
  野間昭典, 松岡達, 皿井伸明
- Publisher
  分子反応過程のモデル化
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Resistance of cardiac cells to NCX knockout: a model study2007
- Author(s)
  Noble D, Sarai N, Noble PJ, Kobayashi T, Matsuoka S, Noma A
- Journal Title
  
  Ann N Y Acad Sci 1099
  
  Pages: 306-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] Role of Ca^<2+> transporters and channels in the cardiac cell volume regulation2007
- Author(s)
  Takeuchi A, Tatsumi S, Sarai N, Terashima K, Matsuoka S, Noma A
- Journal Title
  
  Ann N Y Acad Sci 1099
  
  Pages: 377-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] Acceleration of sensitivity analysis by distributed computation.2007
- Author(s)
  Sarai N
- Journal Title
  
  Conf Proc IEEE Eng Med Biol Soc 1
  
  Pages: 1144-1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] simBio : A Java package for the development of detailed cell models.2006
- Author(s)
  Sarai N, Matsuoka S, Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology. 90・1-3
  
  Pages: 360-377
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Modelling Cl^- homeostasis and volume regulation of the cardiac cell.2006
- Author(s)
  Terashima K, Takeuchi A, Sarai N, Matsuoka S, Shim EB, Leem CH, Noma A.
- Journal Title
  
  Philos Transact A Math Phys Eng Sci. 364(1842)
  
  Pages: 1245-1265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] A Simulation Study to Rescue the Na+/Ca2+ Exchanger Knockout Mice.2006
- Author(s)
  Sarai N, Kobayashi T, Matsuoka S, Noma A
- Journal Title
  
  The Journal of Physiological Sciences 56・3
  
  Pages: 211-217
- NAID
  10020331558
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] Modeling Cl- homeostasis and volume regulation of the cardiac cell.2006
- Author(s)
  Terashima K, Takeuchi A, Sarai N, Matsuoka S, Shim EB, Leem CH
- Journal Title
  
  Philosophical Transactions of Royal Society Series A on 'Biomathematical Modelling' 364・1842
  
  Pages: 1245-1265
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] Ionic Mechanisms of Cardiac Cell Swelling Induced by Blocking Na+/K+ Pump As Revealed by Experiments and2006
- Author(s)
  Takeuchi A, Tatsumi S, Sarai N, Terashima K, Matsuoka S, Noma A
- Journal Title
  
  The Journal of General Physiology 128・5
  
  Pages: 495-507
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] simBio : A Java package for the development of detailed cell models.2006
- Author(s)
  Sarai N, Matsuoka S, Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology. 90
  
  Pages: 360-377
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Modelling Cl-homeostasis and volume regulation of the cardiac cell.2006
- Author(s)
  Terashima, Takeuchi, Sarai, Matsuoka, Shim, Leem, Noma
- Journal Title
  
  Philos Transact A Math Phys Eng Sci. 364・1842
  
  Pages: 1245-1265
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] simBio : A Java package for the development of detailed cell models.2006
- Author(s)
  Sarai N, Matsuoka S, Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology 90・1-3
  
  Pages: 360-377
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] Kyotoモデル-心筋細胞の包括的数理モデル2006
- Author(s)
  皿井伸明, 野間昭典
- Journal Title
  
  医学のあゆみ 217
  
  Pages: 616-622
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] 活動電位のシミュレーション(Kyoto model)2005
- Author(s)
  松岡達, 皿井伸明, 城日加里, 野間昭典
- Journal Title
  
  心臓 37・6
  
  Pages: 486-493
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] 包括的心筋細胞モデル(京都モデル)2005
- Author(s)
  皿井伸明, 松岡達, 野間昭典
- Journal Title
  
  血管医学 6・6
  
  Pages: 657-667
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] 活動電位のシミュレーション(Kyoto model)2005
- Author(s)
  松岡達, 皿井伸明, 城日加里, 野間昭典
- Journal Title
  
  心臓 37・6
  
  Pages: 486-493
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] simBio : A Java package for the development of detailed cell models.2005
- Author(s)
  Sarai N, Matsuoka S, Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology 90・1-3
  
  Pages: 360-377
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] 包括的心筋細胞モデル(京都モデル)2005
- Author(s)
  皿井伸明, 松岡達, 野間昭典
- Journal Title
  
  血管医学 6・6
  
  Pages: 93-103
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] 教育講座:心臓ペースメーカ2005
- Author(s)
  野間昭典, 皿井伸明
- Journal Title
  
  日本生理学雑誌 67・6
  
  Pages: 203-215
- Data Source
  KAKENHI-PROJECT-17700393
[Journal Article] 細胞・生体機能シミュレーションプロジェクト「数理時空間に生体活動を実現する」2004
- Author(s)
  野間昭典, 松岡達, 皿井伸明
- Journal Title
  
  現代医療(現代医療社刊) 36・5
  
  Pages: 1073-1079
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] An in silico study of energy metabolism in cardiac excitation-contraction coupling.2004
- Author(s)
  Matsuoka S, Jo H, Sarai N, Noma A.
- Journal Title
  
  Japanese Journal of Physiology. 54
  
  Pages: 517-522
- NAID
  10014467734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] An in silico study of energy metabolism in cardiac excitation-contraction coupling.2004
- Author(s)
  Matsuoka S, Jo H, Sarai N, Noma A
- Journal Title
  
  Japanese Journal of Physiology. 54・6
  
  Pages: 517-522
- NAID
  10014467734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Simulation of ATP metabolism in cardiac excitation-contraction coupling.2004
- Author(s)
  Matsuoka S., Sarai N., Jo H., Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology. 85
  
  Pages: 279-299
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] An in silico study of energy metabolism in cardiac excitation-contraction coupling.2004
- Author(s)
  Matsuoka S., Jo H., Sarai N., Noma A.
- Journal Title
  
  Jpn. J. Physiol. 54
  
  Pages: 517-522
- NAID
  10014467734
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Simulation of ATP metabolism in cardiac excitation-contraction coupling.2004
- Author(s)
  Matsuoka S, Sarai N, Jo H, Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology. 85
  
  Pages: 279-299
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Intracellular Ca^2+ dynamics and sarcomere length in single ventricular myocytes.2004
- Author(s)
  Powell T, Matsuoka S, Sarai N, Nama A.
- Journal Title
  
  Cell Calcium. 35・6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Intracellular Ca^<2+> dynamics and sarcomere length in single ventricular myocytes.2004
- Author(s)
  Powell T., Matsuoka S., Sarai N., Noma A.
- Journal Title
  
  Cell Calcium. 35
  
  Pages: 535-542
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome.2004
- Author(s)
  Kobori A, Sarai N, Shimizu W, Nakamura Y, Murakami Y, Makiyama T, Ohno S, Takenaka K, Ninomiya T, Fujiwara Y, Matsuoka S, Takano M, Noma A, Kita T, Horie M.
- Journal Title
  
  J Cardiovasc Electrophysiol. 15(2)
  
  Pages: 190-199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome.2004
- Author(s)
  Kobori, Sarai, Shimizu, Nakamura, Murakami, Makiyama, Ohno, Takenaka, Ninomiya, Fujiwara, Matsuoka, Takano, Noma, Kita, Horie.
- Journal Title
  
  J Gardiovasc Electrophysiol. 15・2
  
  Pages: 190-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Intracellular Ca^<2+> dynamics and sarcomere length in single ventricular myocytes.2004
- Author(s)
  Powell T, Matsuoka S, Sarai N, Noma A.
- Journal Title
  
  Cell Calcium. 35
  
  Pages: 535-542
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Simulation of ATP metabolism in cardiac excitation-contraction coupling.2004
- Author(s)
  Matsuoka S, Sarai N, Jo H, Noma A.
- Journal Title
  
  Progress in Biophysics and Molecular Biology. 85・2-3
  
  Pages: 279-99
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] simBio生物学的ダイナミックモデル開発基盤2004
- Author(s)
  皿井伸明, 野間昭典
- Journal Title
  
  BME 18
  
  Pages: 3-11
- NAID
  10012919981
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Role of Individual Ionic Current Systems in the SA Node hypothesized by a model study.2003
- Author(s)
  Sarai N, Matsuoka S, Kuratomi S, Ono K, Noma A.
- Journal Title
  
  Japanese Journal of Physiology. 53
  
  Pages: 125-134
- NAID
  10011229754
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Involvement of Ca^<2+> buffering and Na^+/Ca^<2+> exchange in the positive staircase of contraction in guinea-pig ventricular myocytes.2003
- Author(s)
  Kuratomi S, Matsuoka S, Sarai N, Powell T, Noma A.
- Journal Title
  
  Pflugers Arch. 446
  
  Pages: 347-355
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] イオンチャンネルのバイオシミュレーション2003
- Author(s)
  野間昭典, 松岡達, 皿井伸明, 松田鉄也, 天野晃
- Journal Title
  
  分子心血管病 4・5
  
  Pages: 483-492
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Role of Individual Ionic Current Systems in the SA Node Hypothesized by a Model Study.2003
- Author(s)
  Sarai N, Matsuoka S, Kuratomi S, Ono K, Noma A.
- Journal Title
  
  Japanese Journal of Physiology. 53・2
  
  Pages: 125-134
- NAID
  10011229754
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Role of individual ionic current systems in ventricular cells hypothesized by a model study.2003
- Author(s)
  Matsuoka S, Sarai N, Kuratomi S, Ono K, Noma A.
- Journal Title
  
  Japanese Journal of Physiology. 53・2
  
  Pages: 105-123
- NAID
  10011229678
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Role of individual ionic current systems in ventricular cells hypothesized by a model study.2003
- Author(s)
  Matsuoka S, Sarai N, Kuratomi S, Ono K, Noma A.
- Journal Title
  
  Japanese Journal of Physiology. 53
  
  Pages: 105-123
- NAID
  10011229678
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] オブジェクト指向に基づいた生体機能シミュレーションモデル構築環境2003
- Author(s)
  柴山司, 西俊文, 皿井伸明, 松岡達, 天野晃, 松田哲也, 野間昭典
- Journal Title
  
  電子情報通信学会技術研究報告(MEとバイオサイバネティックス) 103・81
  
  Pages: 23-28
- NAID
  110003286651
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Journal Article] Involvement of Ca^2+ exchange in the positive staircase of contraction in guinea-pig ventricular myocytes.2003
- Author(s)
  Kuratomi S, Matsuoka S, Sarai N, Powell T, Noma A.
- Journal Title
  
  Pflugers Arch. 446・3
  
  Pages: 347-355
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209007
[Patent] 生体パラメータ決定装置、およびプログラム2006
- Inventor(s)
  朝倉圭一, 皿井伸明, 野間昭典
- Industrial Property Rights Holder
  京都大学
- Industrial Property Number
  2006-045670
- Filing Date
  2006-02-22
- Data Source
  KAKENHI-PROJECT-17700393
[Patent] 不整脈危険性評価装置、不整脈危険性評価システム、およびプログラム2006
- Inventor(s)
  皿井伸明, 野間昭典, 朝
- Industrial Property Rights Holder
  京都大学, 日本新薬
- Industrial Property Number
  2006-271601
- Filing Date
  2006-10-03
- Data Source
  KAKENHI-PROJECT-17700393
[Presentation] Estimation of Arrhythmogenic Drug Effects by Using Simulation Method2007
- Author(s)
  松田裕之, 松岡達, 皿井伸明, 野間昭典
- Organizer
  細胞・生体機能シミュレーションプロジェクト」京都大学拠点第4回国際シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-17700393
[Presentation] Development of the Excitation-Contraction Coupling in the Human ventricular Cell Model.2007
- Author(s)
  高畑隆之, 朝倉圭一, 皿井伸明, 松岡達, 野間昭典
- Organizer
  細胞・生体機能シミュレーションプロジェクト」京都大学拠点第4回国際シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-11-12
- Data Source
  KAKENHI-PROJECT-17700393
[Presentation] 薬剤による催不整脈性の数理モデルを用いた定量的評価-Kyoto Modelを用いた検討2007
- Author(s)
  松田裕之, 松岡達, 皿井伸明, 野間昭典.
- Organizer
  第24回日本心電学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-17700393
[Presentation] A Simulation Study on Ca^<2+>-dependent Regulation of Cardiac Energy Metabolism2007
- Author(s)
  齊藤隆太, 皿井伸明, 松岡達, 野間昭典
- Organizer
  細胞・生体機能シミュレーションプロジェクト」京都大学拠点第4回国際シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-17700393

1. NOMA Akinori (00132738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
2. MATSUOKA Satoshi (00263096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results

SARAI Nobuaki 皿井 伸明

Research Projects

Research Products

Co-Researchers

心筋シミュレータを用いた定量的な薬効予測システムの研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of energy metabolism-function coupling in cardiac myocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] simBio 心筋細胞のコンピュータ・シミュレーション2006

Author(s)

Total Pages

Publisher

Data Source

[Book] 心臓のフィジオーム : 電気生理現象のシミュレーション-分子から臓器まで(森北出版株式会社)(岡本良夫編著)2003

Author(s)

Publisher

Description

Data Source

[Book] 心臓のフィジオーム : 電気生理現象のシミュレーション-分子から臓器まで(森北出版株式会社)(岡本良夫編著)2003

Author(s)

Publisher

Description

Data Source

[Journal Article] Resistance of cardiac cells to NCX knockout: a model study2007

Author(s)

Journal Title

Data Source

[Journal Article] Role of Ca^<2+> transporters and channels in the cardiac cell volume regulation2007

Author(s)

Journal Title

Data Source

[Journal Article] Acceleration of sensitivity analysis by distributed computation.2007

Author(s)

Journal Title

Data Source

[Journal Article] simBio : A Java package for the development of detailed cell models.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Modelling Cl^- homeostasis and volume regulation of the cardiac cell.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] A Simulation Study to Rescue the Na+/Ca2+ Exchanger Knockout Mice.2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Modeling Cl- homeostasis and volume regulation of the cardiac cell.2006

Author(s)

Journal Title

Data Source

[Journal Article] Ionic Mechanisms of Cardiac Cell Swelling Induced by Blocking Na+/K+ Pump As Revealed by Experiments and2006

Author(s)

Journal Title

Data Source

[Journal Article] simBio : A Java package for the development of detailed cell models.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Modelling Cl-homeostasis and volume regulation of the cardiac cell.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] simBio : A Java package for the development of detailed cell models.2006

Author(s)

Journal Title

Data Source

SARAI Nobuaki 皿井伸明