Maeda Kazuya 前田和哉

… Alternative Names

MAEDA Kazuya 前田和哉

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Researcher Number	00345258
Other IDs	https://orcid.org/0000-0002-9174-5213
Affiliation (Current)	2025: 北里大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 北里大学, 薬学部, 教授 2020: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2015 – 2019: 東京大学, 大学院薬学系研究科(薬学部), 講師 2012 – 2016: 東京大学, 薬学研究科(研究院), 講師 2013 – 2014: 東京大学, 大学院薬学系研究科, 講師 … More 2012: 東京大学, 大学院・薬学系研究科, 講師 2007 – 2011: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor 2008: The University of Tokyo, 大学院薬学系研究科, 助教 2005 – 2006: 東京大学, 大学院薬学系研究科, 助手 2003 – 2005: 東京大学, 大学院・薬学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Basic Section 28050:Nano/micro-systems-related / Drug development chemistry / Complex systems / Biological Sciences
Keywords	Principal Investigator トランスポーター / 薬物動態 / 肝細胞 / 胆汁排泄 / 肝取り込み / ヒト新鮮消化管 / 消化管吸収 / バイオアベイラビリティ / 寄与率 / ヒト肝細胞 … More / in silico プロファイリング / 下痢 / EGF受容体チロシンキナーゼ阻害薬 / 細胞内ATP / 小腸幹細胞 / オルガノイド / in silicoプロファイリング / 消化管幹細胞 / 薬剤誘導性消化器毒性 / 薬物トランスポーター / 消化管吸収予測 / 代謝酵素 / Ussing chamber / 経細胞輸送 / crypt / 薬物速度論モデル / 薬物相互作用 / 薬物動態の予測 / 肝胆系輸送 / サンドイッチ培養 / ヒト肝キメラマウス / 薬物動態予測 / ヒト肝臓キメラマウス / プロスタグランジン / 活性化 / 肝線維化 / OATP2A1 / 肝星細胞 / ＨｅｐａＲＧ細胞 / LC-MS/MS / sandwich培養 / 一分子測定 / 質量分析計 / 数理モデル / 肝初回通過 / MRP2 / OATP1B3 / 体内動態 / 抗がん剤 / 好中球 / 血液毒性 / 薬物間相互作用 / 腎スライス / 肝腎振り分け / アンジオテンシンII受容体拮抗薬 / 共発現系 / 生活習慣病 / 遺伝子多型 / 個別化医療 / 薬剤反応性 / OATP … More Except Principal Investigator トランスポーター / 薬物間相互作用 / 体内動態 / 薬物トランスポーター / 薬物動態 / 薬物相互作用 / biliary excretion / 胆汁排泄 / Mrps / transporter / pharmacophore / 代謝酵素 / 生理学的モデル / 血液脳関門 / CYP3A4 / フェノタイピング / プローブ薬 / 生理学的薬物速度論モデル / 薬剤反応性 / 薬物相互作用の予測 / 内因性バイオマーカー / 生理学的薬物速度論（PBPK）モデル / 内在性バイオマーカー / 生理学的薬物速度論モデル（PBPK） / マイクロ流体デバイス / 腸管 / MPS / Organ-on-a-chip / 生体模倣システム / 代謝物プロファイル解析 / メタボロミクス / 内在性代謝物 / ヒト由来試料 / 初代培養上皮細胞 / 内因性基質 / 吸収・分泌 / オルガノイド / スフェロイド / 薬物輸送 / in vitroモデル / 基質探索 / オーファントランスポーター / メタボロミクス解析 / 基質同定 / 膜輸送 / 臨床薬理試験 / 肝機能障害 / 腎機能障害 / 特殊患者集団 / 用法用量 / 添付文書 / sinusoidal efflux / intestine absorption / tubular secretion / probe drug / drug dispostion / 肝シヌソイド側排出 / 消化管吸収 / 腎尿細管分泌 / drug-drue interaction / renal excretion / anti-HIV drugs / diuretics / transporters / metabolic enzymes / SULT / Mrp4 / Mrp3 / 小腸吸収 / 腎排泄 / HIV治療薬 / 利尿薬 / substrate specificity / organic anion / efflux transport / blood-brain barrier / 基質選択性 / ファーマコフォア / 有機アニオン / 排出輸送 / バーチャルクリニカルスタディ / 個人間変動 / 創薬支援システム / PET/SPECTプローブ / モデリング＆シミュレーション / 遺伝子多型 / 薬物代謝酵素 / ＰＥＴ / 階層構造 / スケーリングファクター / 肝異物解毒システム / トランスロケーションモデル / クラスターニュートン法 / 代謝物 / 薬物動態学 / cluster newton method / PET / 体内動態予測 / 分子イメージング / 脳・神経 / 薬学 / MATE / OAT / 腎スライス / 薬剤感受性 / atorvastatin / 肝クリアランス / 律速段階 / OATP / MATEs / シメチジン / ヒト腎スライス / ヒト肝細胞 / クリアランスの律速段階 / プラバスタチン / オルメサルタン / UGT / テルミサルタン / ゲノム Less

Development of gut microphysiological system through functional element reconstruction approach
- Principal Investigator
  
  木村啓志
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28050:Nano/micro-systems-related
- Research Institution
  Tokai University
Construction of the novel evaluation systems and the methodologies for quantitative risk assessment of drug-induced intestinal toxicityPrincipal Investigator
- Principal Investigator
  
  前田和哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kitasato University
Integrated development of quantitative prediction methods for complex drug-drug interactions involving transporters
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
Pharmacokinetic study on transporters in the xenobiotic detoxification among the liver, small intestine and kidney
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Establishment of the novel experimental systems with human freshly-isolated intestinal tissues for the accurate prediction of intestinal drug absorption in humansPrincipal Investigator
- Principal Investigator
  
  Kazuya Maeda
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kitasato University
  The University of Tokyo
Precise quantative prediction of complex drug-drug interactions with the use of human liver chimeric micePrincipal Investigator
- Principal Investigator
  
  Maeda Kazuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
特殊な患者集団に対する添付文書の記載と情報に関する研究
- Principal Investigator
  
  草間真紀子
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Mitigation of the liver injury based on the regulation of membrane transport in hepatic stellate cellsPrincipal Investigator
- Principal Investigator
  
  Maeda Kazuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Analysis of pharmacokinetics and toxicological effects of drugs by quantitative estimation of human biliary excretion of drugs at a single cell levelPrincipal Investigator
- Principal Investigator
  
  MAEDA Kazuya
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Medical pharmacy
- Research Institution
  Institute of Physical and Chemical Research
Quantitative prediction of the bioavailability of drugs based on the activities of dexofication enzymes/transportersPrincipal Investigator
- Principal Investigator
  
  MAEDA Kazuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Comprehensive analysis of the factors regulating the disposition of small molecules at organ and tissue levels
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Role of drug transporters in the anticancer drug-induced hematotoxicityPrincipal Investigator
- Principal Investigator
  
  MAEDA Kazuya
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
薬物動態・薬効の変動に関与する薬物トランスポーターの遺伝子多型の包括的実証研究
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humans
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of quantitative evaluation method of the drug transport systems at the blood brain barrier which influences the CNS effect.
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Prediction of hepatic and renal clearance of drugs by using humanand animal-derived tissue samples and gene expression systemsPrincipal Investigator
- Principal Investigator
  
  MAEDA Kazuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Establishment of drugs for probing in vivo activity of xenobiotic transporters in humans
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
トランスポーターの遺伝子多型が循環器系薬剤の臨床薬物動態に与える影響の定量的考察Principal Investigator
- Principal Investigator
  
  前田和哉
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
ヒト肝臓における薬物輸送に関与するトランスポーターの寄与率の定量的評価法の構築Principal Investigator
- Principal Investigator
  
  前田和哉
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrier
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

[Book] Predictio of hepatic transporter-mediated drug-drug interaction from in vitro data. In:Transporters in Drug Development2013
- Author(s)
  Maeda K, Sugiyama Y
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-23136101
[Book] Excretion systems in: "Encyclopedia of drug metabolism and interactions"2012
- Author(s)
  Maeda K, and Sugiyama Y
- Publisher
  John Wiley & Sons, Inc., New York
- Data Source
  KAKENHI-PROJECT-24229002
[Book] 創薬技術の革新マイクロドーズからPET分子イメージングへの新展開(編集杉山雄一、山下伸二、栗原千絵子)(薬物動態関連遺伝子多型による薬物動態の変動予測法の開発)2010
- Author(s)
  楠原洋之、前田和哉、杉山雄一
- Total Pages
  10
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390046
[Book] 薬物動態関連遺伝子多型による薬物動態の変動予測法の開発"創薬技術の革新マイクロドーズからPET分子イメージングへの新展開"(編集杉山雄一、山下伸二、栗原千絵子)2010
- Author(s)
  楠原洋之、前田和哉、杉山雄一
- Total Pages
  10
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390046
[Book] John Wiley and Sons, Inc.2007
- Author(s)
  Maeda K and Sugiyama Y.
- Publisher
  Drug Transporters (分担執筆:In vitro-in vivo scale-up of drug transport activities)
- Data Source
  KAKENHI-PROJECT-19790119
[Book] 最新創薬学2007(分担執筆:肝取り込み・排泄の予測)2007
- Author(s)
  前田和哉
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-19790119
[Book] 最新創薬学2007(分担執筆:肝取り込み・排泄の予測)2007
- Author(s)
  前田和哉
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-19790119
[Book] Drug Transporters (分担執筆:In vitro-in vivo scale-up of drug transport activities)2007
- Author(s)
  Maeda K, et. al.
- Publisher
  John Wiley and Sons, Inc.
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] Quantitative Prediction of Intestinal Absorption of Drugs from In Vitro Study: Utilization of Differentiated Intestinal Epithelial Cells Derived from Intestinal Stem Cells at Crypts2023
- Author(s)
  Maeda Kazuya
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 9 Pages: 1136-1144
- DOI
  10.1124/dmd.122.000966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27347
[Journal Article] Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys2023
- Author(s)
  Hashimoto Yoshiki、Maeda Kazuya、Shimomura Osamu、Miyazaki Yoshihiro、Hashimoto Shinji、Moriyama Akiko、Oda Tatsuya、Kusuhara Hiroyuki
- Journal Title
  
  Toxicology in Vitro
  
  Volume: 93 Pages: 105691-105691
- DOI
  10.1016/j.tiv.2023.105691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KJ0596, KAKENHI-PROJECT-23K27347
[Journal Article] ヒトcrypt由来分化吸収上皮細胞を用いた薬物の消化管吸収性・消化器毒性の評価2022
- Author(s)
  前田和哉
- Journal Title
  
  Drug Delivery System
  
  Volume: 37 Pages: 303-311
- Data Source
  KAKENHI-PROJECT-20H03402
[Journal Article] ヒト/動物消化管crypt由来分化消化管上皮細胞を用いた新規薬物の消化管吸収予測系の構築2022
- Author(s)
  前田和哉
- Journal Title
  
  ILSI Japan
  
  Volume: 150 Pages: 13-20
- Data Source
  KAKENHI-PROJECT-20H03402
[Journal Article] ヒト/動物消化管crypt由来分化消化管上皮細胞を用いた新規薬物の消化管吸収予測系の構築2022
- Author(s)
  前田和哉
- Journal Title
  
  ILSI Japan
  
  Volume: 150 Pages: 13-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401
[Journal Article] Quantitative prediction of pharmacokinetic properties of drugs in humans: Recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood brain barrier2022
- Author(s)
  Hashimoto Yoshiki、Michiba Kazuyoshi、Maeda Kazuya、Kusuhara Hiroyuki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 1 Pages: 142-151
- DOI
  10.1016/j.jphs.2021.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20H03402
[Journal Article] Usefulness of Human Jejunal Spheroid Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans2022
- Author(s)
  Michiba Kazuyoshi、Maeda Kazuya、Shimomura Osamu、Miyazaki Yoshihiro、Hashimoto Shinji、Oda Tatsuya、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 3 Pages: 204-213
- DOI
  10.1124/dmd.121.000796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20H03402, KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-23K24172
[Journal Article] Prospect of in vitro Bile Fluids Collection in Improving Cell-Based Assay of Liver Function2021
- Author(s)
  Rizki-Safitri Astia、Tokito Fumiya、Nishikawa Masaki、Tanaka Minoru、Maeda Kazuya、Kusuhara Hiroyuki、Sakai Yasuyuki
- Journal Title
  
  Frontiers in Toxicology
  
  Volume: 3 Pages: 657432-657432
- DOI
  10.3389/ftox.2021.657432
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PLANNED-20H05745
[Journal Article] Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development2021
- Author(s)
  Mochizuki Tatsuki、Mizuno Tadahaya、Maeda Kazuya、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100358-100358
- DOI
  10.1016/j.dmpk.2020.09.003
- NAID
  210000177785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20J14855
[Journal Article] Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum2021
- Author(s)
  Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda, Hiroyuki Kusuhara
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 49 Issue: 1 Pages: 84-93
- DOI
  10.1124/dmd.120.000138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03402
[Journal Article] トランスポーターを介した薬物相互作用　～臨床事例とその回避のための予測戦略～2019
- Author(s)
  前田　和哉
- Journal Title
  
  医学のあゆみ
  
  Volume: 271 Pages: 136-145
- Data Source
  KAKENHI-PROJECT-17H04006
[Journal Article] Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.2017
- Author(s)
  Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 24 Issue: 9 Pages: 30084-30089
- DOI
  10.1016/j.xphs.2017.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Is ethnic variability in the exposure to rosuvastatin explained only by genetic polymorphisms in OATP1B1 and BCRP or should the contribution of intrinsic ethnic differences in OATP1B1 be considered?2017
- Author(s)
  Sugiyama Y, Maeda K, Toshimoto K.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Issue: 9 Pages: 2227-2230
- DOI
  10.1016/j.xphs.2017.04.074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K18972
[Journal Article] Small-dosing clinical study: Pharmacokine- tic, pharmacogeno- mics (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit juice) profiles of 5 probes for OATP2B1 and BCRP.2017
- Author(s)
  Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Comparison of methods for estimating unbound intracellular-to-medium concentration ratios in rat and human hepatocytes using statins.2017
- Author(s)
  Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 印刷中 Issue: 7 Pages: 779-789
- DOI
  10.1124/dmd.116.074823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.2016
- Author(s)
  Yoshikado T, Yoshida K, Kotani N, Nakada T, Asaumi R, Toshimoto K. Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 100 Issue: 5 Pages: 513-523
- DOI
  10.1002/cpt.391
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 to Develop Sensitive Fluorescence-Based Oatp1B1 Inhibition Assays.2016
- Author(s)
  Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Mol Pharm
  
  Volume: 13 Issue: 2 Pages: 438-448
- DOI
  10.1021/acs.molpharmaceut.5b00664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (Fa) and Intestinal Availability (Fg): Effect of P-glycoprotein and CYP3A on Fa and Fg.2016
- Author(s)
  Tanaka Y, Kitamura Y, Maeda K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 105 Issue: 2 Pages: 431-442
- DOI
  10.1016/j.xphs.2015.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Radiosynthesis of Novel Pitavastatin Derivative ([18 F] Ptv-F1) as a Tracer for Hepatic Oatp Using a One-Pot Synthetic Procedure.2016
- Author(s)
  Kimura H, Yagi Y, Arimitsu K, Maeda K, Ikejiri K, Takano J, Kusuhara H, Kagawa S, Ono M, Sugiyama Y, Saji H.
- Journal Title
  
  J Labelled Comp Radiopharm
  
  Volume: 59 Issue: 13 Pages: 565-575
- DOI
  10.1002/jlcr.3464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26461816
[Journal Article] Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.2016
- Author(s)
  Ose A, Toshimoto K, Ikeda K, Maeda K, Yoshida S, Yamashita F, Hashida M, Ishida T, Akiyama Y, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Pages: 2222-2230
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Usefulness of a Model-Based Approach for Estimating in Vitro P-Glycoprotein Inhibition Potency in a Transcellular Transport Assay.2016
- Author(s)
  Kishimoto W, Ishiguro N, Ludwig- Schwellinger E, Ebner T, Maeda K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Issue: 2 Pages: 891-896
- DOI
  10.1016/j.xphs.2015.11.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Clarification of the Mechanism of Clopidogrel- Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.2016
- Author(s)
  Kim SJ, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Issue: 10 Pages: 1622-1632
- DOI
  10.1124/dmd.116.070276
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Investigation of Endogenous Compounds Applicable to Drug - Drug Interaction Studies Involving the Renal Organic Anion Transporters, Oat1 and Oat3, in Humans.2016
- Author(s)
  Tsuruya Y, Kato K, Sano Y, Imamura Y, Maeda K, Kumagai Y, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Issue: 12 Pages: 1925-1933
- DOI
  10.1124/dmd.116.071472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] The Prediction of the Relative Importance of Cyp3a/P-Glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model.2016
- Author(s)
  Takano J, Maeda K, Bolger MB, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Issue: 11 Pages: 1808-1818
- DOI
  10.1124/dmd.116.070011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Organic Anion Transporting Polypeptide (OATP)1B1 and OATP1B3 as Important Regulators of the Pharmacokinetics of Substrate Drugs2015
- Author(s)
  Kazuya Maeda
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 2 Pages: 155-168
- DOI
  10.1248/bpb.b14-00767
- NAID
  130004872264
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Analysis of the ABCG2 c.421C>A Polymorphism Effect on In Vivo Transport Activity of Breast Cancer Resistance Protein (BCRP) Using an Intestinal Absorption Model2015
- Author(s)
  Tanaka Y, Kitamura Y, Maeda K, Sugiyama Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Issue: 9 Pages: 3093-3048
- DOI
  10.1002/jps.24366
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
[Journal Article] A clinical pharmacokinetic microdosing study of docetaxel with Japanese patients with cancer.2015
- Author(s)
  Fujita K, Yoshino E, Kawara K, Maeda K, Kusuhara H, Sugiyama Y, Yokoyama T, Kaneta T, Ishida H, Sasaki Y.
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 76 Issue: 4 Pages: 793-801
- DOI
  10.1007/s00280-015-2844-2
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] The synthesis of [18F]- pitavastatin as a tracer for hATP using the Suzuki coupling2015
- Author(s)
  Y. Yagi, H. Kimura, K. Arimitsu, M. Ono, K. Maeda, H. Kusuhara, T. Kajimoto, Y. Sugiyama, H. Saji
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 4 Pages: 1113-1121
- DOI
  10.1039/c4ob01953a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460022, KAKENHI-PROJECT-24229002
[Journal Article] Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions.2015
- Author(s)
  Izumi S, Nozaki Y, Maeda K, Komori T, Takenaka O, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Issue: 2 Pages: 235-247
- DOI
  10.1124/dmd.114.059105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice.2015
- Author(s)
  Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi JI, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Pharm Res
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23136101
[Journal Article] Effects of Cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects2015
- Author(s)
  Tomaru A, Takeda-Morishita M, Maeda K, Banba H, Takayama K, Kumagai Y, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 印刷中 Issue: 3 Pages: 221-226
- DOI
  10.1016/j.dmpk.2015.01.002
- NAID
  50014429954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24689009, KAKENHI-PROJECT-24229002
[Journal Article] Inhibitory effects of para-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.2014
- Author(s)
  Maeda K, Tian Y, Fujita T, Ikeda Y, Kumagai Y, Kondo T, Tanabe K, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Eur J Pharm Sci
  
  Volume: - Pages: 94-103
- DOI
  10.1016/j.ejps.2014.04.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590646, KAKENHI-PROJECT-24229002
[Journal Article] 6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.2014
- Author(s)
  Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 4 Pages: 685-94
- DOI
  10.1124/dmd.113.055475
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659071
[Journal Article] Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17beta-glucuronide, estrone-3-sulfate, and sulfobromophthalein.2013
- Author(s)
  Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H and Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Issue: 10 Pages: 1859-1866
- DOI
  10.1124/dmd.113.052290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Transporter biology in drug approval: regulatory aspects.2013
- Author(s)
  Maeda K and Sugiyama Y.
- Journal Title
  
  Mol Aspects Med
  
  Volume: 34 Issue: 2-3 Pages: 711-718
- DOI
  10.1016/j.mam.2012.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition : their roles in hepatic clearance and intestinal absorption2013
- Author(s)
  Shitara y Maeda K, Ikejiri K, Yoshida K, Horie T and Sugiyama Y
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 34 Pages: 45-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24689009
[Journal Article] Hepatic and intestinal drug transporters : prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms2013
- Author(s)
  Yoshida K, Maeda K and Sugiyama Y
- Journal Title
  
  Annu Rev Pharmacol Toxicol
  
  Volume: 53 Issue: 1 Pages: 581-612
- DOI
  10.1146/annurev-pharmtox-011112-140309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09907, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
[Journal Article] Transporter biology in drug approval : Regulatory aspects2013
- Author(s)
  Maeda K and Sugiyama Y
- Journal Title
  
  Mol Aspects Med
  
  Volume: 34 Pages: 711-718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24689009
[Journal Article] Ethnic Variability in the Plasma Exposures of 0ATPlBl Substrates Such as HMG-CoA Reductase Inhibitors : A Kinetic Consideration of Its Mechanism2013
- Author(s)
  Tomita Y, Maeda K, and Sugiyama Y
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: (in press) Issue: 1 Pages: 37-51
- DOI
  10.1038/clpt.2012.221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24689009, KAKENHI-PLANNED-23136101
[Journal Article] Investigation of the effect of the uneven distribution of CYP3A4 and P-glycoprotein in the intestine on the barrier function against xenobiotics: a simulation study.2013
- Author(s)
  Watanabe T, Maeda K, Nakai C and Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Issue: 9 Pages: 3196-3204
- DOI
  10.1002/jps.23623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24689009
[Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats.2013
- Author(s)
  Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 347 Issue: 1 Pages: 193-202
- DOI
  10.1124/jpet.113.206425
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.2013
- Author(s)
  Ieiri I, Tsunemitsu S, Maeda K, Ando Y, Izumi N, Kimura M, Yamane N, Okuzono T, Morishita M, Kotani N, Kanda E, Deguchi M, Matsuguma K, Matsuki S, Hirota T, Irie S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Clin Pharmacol, 1-16
  
  Volume: 53 Issue: 6 Pages: 1-16
- DOI
  10.1002/jcph.62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24689009
[Journal Article] Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition : their roles in hepatic clearance and intestinal absor ption.2013
- Author(s)
  Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 34 Issue: 1 Pages: 45-78
- DOI
  10.1002/bdd.1823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09907, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
[Journal Article] Cost-effectiveness analysis of microdose clinical trials in drug development.2013
- Author(s)
  Yamane N, Igarashi A, Kusama M, Maeda K, Ikeda T and Sugiyama Y.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 187-195
- NAID
  130004463302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Studies on the intestinal absorption characteristics of sulfasalazine, a breast cancer resistance protein (BCRP) substrate.2013
- Author(s)
  Tomaru A, Morimoto N, Morishita M, Takayama K, Fujita T, Maeda K, Kusuhara H and Sugiyama Y.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 71-74
- NAID
  130004463289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Prediction of Hepatic Transporter-mediated Drug-drug interaction from in vitro data2013
- Author(s)
  Maeda K, Sugiyama Y
- Journal Title
  
  Transporters in Drug Development
  
  Volume: 1 Pages: 121-153
- Data Source
  KAKENHI-PROJECT-24689009
[Journal Article] Estimation of feasible solution space using Cluster Newton Method: application to pharmacokinetic analysis of irinotecan with physiologically- based pharmacokinetic models2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A
- Journal Title
  
  BMC Systems Biology
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101
[Journal Article] Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.2013
- Author(s)
  Yoshida K, Takano J, Ishizu Y, Lezhava A, Ieiri I, Maeda K, Hayashizaki Y and Sugiyama Y.
- Journal Title
  
  AAPS J
  
  Volume: 15 Issue: 2 Pages: 618-622
- DOI
  10.1208/s12248-013-9471-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Microdose pharmacogenetic study of (1)(4)C-tolbutamide in healthy subjects with accelerator mass spectrometry to examine the effects of CYP2C9 *3 on its pharmacokinetics and metabolism.2013
- Author(s)
  Ikeda T, Aoyama S, Tozuka Z, Nozawa K, Hamabe Y, Matsui T, Kainuma M, Hasegawa S, Maeda K and Sugiyama Y.
- Journal Title
  
  Eur J Pharm Sci
  
  Volume: 49 Issue: 4 Pages: 642-648
- DOI
  10.1016/j.ejps.2013.05.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.2012
- Author(s)
  Ieiri I, Fukae M, Maeda K, Ando Y, Kimura M, Hirota T, Nakamura T, Iwasaki K, Matsuki S, Matsuguma K, Kanda E, Deguchi M, Irie S, Sugiyama Y.
- Journal Title
  
  Int J Clin Pharmacol Ther
  
  Volume: 50 Issue: 10 Pages: 689-700
- DOI
  10.5414/cp201763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP2012
- Author(s)
  Kusuhara H, et al
- Journal Title
  
  Br J Pharmacol
  
  Volume: (In press) Issue: 6 Pages: 1793-1803
- DOI
  10.1111/j.1476-5381.2012.01887.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-23590206, KAKENHI-PROJECT-24229002
[Journal Article] Prediction of the degree of transporter-mediated drug-drug interactions involving OATP substrates based on in vitro inhibition studies2012
- Author(s)
  Kenta Yoshida, Kazuya Maeda, Yuichi Sugiyama
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3.2012
- Author(s)
  Shimizu K, Takashima T, Yamane T, Sasaki M, Kageyama H, Hashizume Y, Maeda K, Sugiyama Y, Watanabe Y, Senda M.
- Journal Title
  
  Nucl Med Biol
  
  Volume: 39 Issue: 6 Pages: 847-53
- DOI
  10.1016/j.nucmedbio.2012.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Positron emission tomography (PET) imaging-based evaluation of hepatobiliary transport in humans using 15R-[^<11>C]TIC-Me2012
- Author(s)
  Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
- Journal Title
  
  J. Nucl. Med.
  
  Volume: 53 Issue: 5 Pages: 741-748
- DOI
  10.2967/jnumed.111.098681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-23300241, KAKENHI-PROJECT-24229002
[Journal Article] Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals2012
- Author(s)
  Kato K, et al
- Journal Title
  
  Pharmacogenet Genomics
  
  Volume: 22 Issue: 5 Pages: 344-354
- DOI
  10.1097/fpc.0b013e3283517012
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
[Journal Article] Prediction of the degree oftransporter-mediated drug-drug interactions involving OATP substrates based on in vitro inhibition studies、2012
- Author(s)
  Yoshida K、Maeda K、Sugiyama Y
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.2012
- Author(s)
  Nakakariya M, Ono M, Amano N, Moriwaki T, Maeda K, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 40 Issue: 3 Pages: 602-9
- DOI
  10.1124/dmd.111.042101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit Juice) profiles of celiprolol following the oral microdose and therapeutic dose.2012
- Author(s)
  Ieiri I, Doi Y, Maeda K, Sasaki T, Kimura M, Hirota T, Chiyoda T, Miyagawa M, Irie S, Iwasaki K, Sugiyama Y.
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 52 Issue: 7 Pages: 1078-89
- DOI
  10.1177/0091270011408612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans byIn Vitro Uptake Experiments2011
- Author(s)
  Watanabe T、Kusuhara H、Watanabe T、Debori Y、Maeda K、Kondo T、NakayamaH、Horita S、Ogilvie BW、Parkinson A、Hu Z、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Issue: 6 Pages: 1031-1038
- DOI
  10.1124/dmd.110.036129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011
- Author(s)
  Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos in press
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 薬物動態研究におけるPET試験の意義2011
- Author(s)
  前田和哉
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 19巻 Pages: 92-98
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes2011
- Author(s)
  Kotani N、Maeda K、Watanabe T、HiramatsuM、Gong L-K、Bi Y-A、Takezawa T、Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Issue: 9 Pages: 1503-1510
- DOI
  10.1124/dmd.111.038968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 開発戦略におけるマイクロドーズ臨床試験2011
- Author(s)
  前田和哉
- Journal Title
  
  臨床薬理
  
  Volume: 41巻 Pages: 81-88
- NAID
  10029432256
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011
- Author(s)
  Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17,18,19,20-tetra norisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther 335
  
  Pages: 314-323
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] OATP1B1の遺伝子多型が基質薬物の体内動態・薬効・副作用に与える影響2010
- Author(s)
  前田和哉
- Journal Title
  
  Drug Metab Pharmacokinet(ニュースレター)(招待) 25
  
  Pages: 9-14
- NAID
  10027583992
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] 胆汁排泄とトランスポーター2010
- Author(s)
  前田和哉
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 135巻 Pages: 76-79
- NAID
  10026334729
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The Use of Hepatocytes to Investigate Drug Uptake Transporters.2010
- Author(s)
  Maeda, K, Sugiyama, Y.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 640 Pages: 327-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17, 18, 19, 20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther. 335
  
  Pages: 314-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] 薬物相互作用による薬物動態の変動予測法の開発2010
- Author(s)
  前田和哉、杉山雄一
- Journal Title
  
  遺伝子医学MOOK別冊(創薬技術の革新:マイクロドーズからPET分子イメージングへの新展開)
  
  Volume: (招待) Pages: 63-73
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] The use of hepatocytes to investigate drug uptake transporters.2010
- Author(s)
  Maeda K., Sugiyama Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 640 Pages: 327-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 胆汁排泄とトランスポーター2010
- Author(s)
  前田和哉
- Journal Title
  
  日本薬理学雑誌(招待) 135
  
  Pages: 76-79
- NAID
  10026334729
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] The use of hepatocytes to investigate drug uptake transporters2010
- Author(s)
  Maeda K、Sugiyama Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 640巻 Pages: 327-353
- DOI
  10.1007/978-1-60761-688-7_18
- ISBN
  9781607616870, 9781607616887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 胆汁排泄とトランスポーター2010
- Author(s)
  前田和哉
- Journal Title
  
  日本薬理学雑誌 135(2)
  
  Pages: 76-79
- NAID
  10026334729
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 開発戦略におけるマイクロドーズ臨床試験2010
- Author(s)
  前田和哉
- Journal Title
  
  臨床薬理
  
  Volume: 41(招待) Pages: 27-34
- NAID
  10029432256
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] ドセタキセルに起因する好中球減少症を決定するOATP1B3, MRP2の役割に関する解析2010
- Author(s)
  山田哲裕、前田和哉、清谷一馬、莚田泰誠、中村祐輔、杉山雄一
- Journal Title
  
  Jpn Pharmacol Ther 38(suppl.2)
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution andclearance in humans2010
- Author(s)
  Watanabe T、Kusuhara H、Sugiyama Y
- Journal Title
  
  J Pharmacokinet Pharmacodyn
  
  Volume: 37巻 Issue: 6 Pages: 575-590
- DOI
  10.1007/s10928-010-9176-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 胆汁排泄とトランスポーター2010
- Author(s)
  前田和哉
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 135(招待) Pages: 76-79
- NAID
  10026334729
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] 創薬におけるin vitroヒト組織細胞を利用した薬物動態・薬効・副作用予測の重要性2010
- Author(s)
  前田和哉、杉山雄一
- Journal Title
  
  医学のあゆみ(招待) 232
  
  Pages: 83-88
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] ドセタキセルに起因する好中球減少症を決定するOATP1B3,MRP2の役割に関する解析2010
- Author(s)
  山田哲裕、前田和哉、清谷一馬、莚田泰誠、中村祐輔、杉山雄一
- Journal Title
  
  Jpn Pharmacol Ther
  
  Volume: 38(suppl.2)
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines2010
- Author(s)
  Ichihara S, Kikuchi R, Kusuhara H, Imai S, Maeda K, Sugiyama Y.
- Journal Title
  
  Pharm Res 27(3)
  
  Pages: 510-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using(15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 335 Pages: 314-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 創薬におけるin vitroヒト組織細胞を利用した薬物動態・薬効・副作用予測の重要性2010
- Author(s)
  前田和哉、杉山雄一
- Journal Title
  
  医学のあゆみ
  
  Volume: 232 Pages: 83-88
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] OATP1B1の遺伝子多型が基質薬物の体内動態・薬効・副作用に与える影響2010
- Author(s)
  前田和哉
- Journal Title
  
  Drug Metab Pharmacokinet(ニュースレター)
  
  Volume: 25(招待) Pages: 9-14
- NAID
  10027583992
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] 薬物相互作用による薬物動態の変動予測法の開発2010
- Author(s)
  前田和哉、杉山雄一
- Journal Title
  
  遺伝子医学MOOK別冊(創薬技術の革新:マイクロドーズからPET分子イメージングへの新展開)(招待)
  
  Pages: 63-73
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] The Use of Hepatocytes to Investigate Drug Uptake Transporters.2010
- Author(s)
  Maeda, K., Sugiyama, Y.
- Journal Title
  
  Methods Mol Biol 640
  
  Pages: 327-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010
- Author(s)
  Kitamura Y、Kusuhara H、Sugiyama Y
- Journal Title
  
  Pharm Res
  
  Volume: 27巻 Issue: 4 Pages: 665-672
- DOI
  10.1007/s11095-009-0047-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 isinvolved in the drug-drug interaction causedby cimetidine2009
- Author(s)
  Matsushima S、Maeda K、Inoue K、Ohta KY、Yuasa H、Kondo T、Nakayama H、Horita S、Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Issue: 3 Pages: 555-559
- DOI
  10.1124/dmd.108.023911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] トランスポーターと薬物毒性2009
- Author(s)
  前田和哉
- Journal Title
  
  遺伝子医学MOOK最新トランスポーター研究2009 12
  
  Pages: 163-174
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide.2009
- Author(s)
  Miyagawa M, Maeda K, Aoyama A, Sugiyama Y.
- Journal Title
  
  J Pharmacol Exp Ther 329(2)
  
  Pages: 551-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] トランスポーターと薬物毒性2009
- Author(s)
  前田和哉
- Journal Title
  
  遺伝子医学MOOK「最新トランスポーター研究2009」(招待) 12
  
  Pages: 163-174
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments2009
- Author(s)
  Watanabe T, Maeda K, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama, Y.
- Journal Title
  
  Drug Metab Dispos (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.2009
- Author(s)
  Watanabe T, Maeda K, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine2009
- Author(s)
  Matsushima S, Maeda K, Inou e K, Ohta KY, Yuasa H, Kond o T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 555-559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] 薬物動態関連遺伝子変異と臨床薬理2009
- Author(s)
  山田哲裕、前田和哉、杉山雄一
- Journal Title
  
  治療学 43(3)
  
  Pages: 28-39
- NAID
  10018117709
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide2009
- Author(s)
  Miyagawa M、Maeda K、Aoyama A、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 329巻 Issue: 10 Pages: 551-557
- DOI
  10.1124/dmd.109.027193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Quantitative population pharmacokinetic analysis of pravastatin using an enterohepatic circulation model combined with pharmacogenomic Information on SLCO1B1 and ABCC2 polymorphisms2009
- Author(s)
  Ide, T., Sasaki, T., Maeda, K., Higuchi, S., Sugiyama, Y., Ieiri, I.
- Journal Title
  
  J Clin Pharmacol 49
  
  Pages: 1309-1317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data.2009
- Author(s)
  Kusama M, Maeda K, Chiba K, Aoyama A, Sugiyama Y.
- Journal Title
  
  Pharm Res. 26
  
  Pages: 822-835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The 8th and 9th transmembrane domains in organic anion trans porting polypeptide (OATP) 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17{beta}-?D-glucuronide.2009
- Author(s)
  Miyagawa M, Maeda K, Aoyama A, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.2009
- Author(s)
  Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 555-559
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Physiologically Based Pharmacokinetic Modeling to Predict Transporter-mediated Clearance and Distribution of Pravastatin in Humans2009
- Author(s)
  Watanabe, T., Kusuhara, H., Maeda, K., Shitara, Y. and Sugiyama, Y.
- Journal Title
  
  J Pharmacol Exp Ther 328
  
  Pages: 652-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] 薬物動態と医薬品の薬効・副作用-トランスポーターを中心として2009
- Author(s)
  山田哲裕、前田和哉、杉山雄一
- Journal Title
  
  治療学(招待) 43(12)
  
  Pages: 1267-1280
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] 薬物動態と医薬品の薬効・副作用―トランスポーターを中心として2009
- Author(s)
  山田哲裕、前田和哉、杉山雄一
- Journal Title
  
  治療学 43(12)
  
  Pages: 1267-1280
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data2009
- Author(s)
  Kusama M、Maeda K、Chiba K、Aoyama A、Sugiyama Y
- Journal Title
  
  Pharm Res
  
  Volume: 26巻 Issue: 4 Pages: 822-835
- DOI
  10.1007/s11095-008-9781-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-21790109
[Journal Article] 薬物動態関連遺伝子変異と臨床薬理2009
- Author(s)
  山田哲裕、前田和哉、杉山雄一
- Journal Title
  
  治療学 43(3)
  
  Pages: 28-39
- NAID
  10018117709
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] 薬物動態関連遺伝子変異と臨床薬理2009
- Author(s)
  山田哲裕、前田和哉、杉山雄一
- Journal Title
  
  治療学(招待) 43(3)
  
  Pages: 28-39
- NAID
  10018117709
- Data Source
  KAKENHI-PROJECT-21790145
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.2009
- Author(s)
  Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 555-559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans2008
- Author(s)
  Kitamura S、Maeda K、Sugiyama Y
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume: 377巻 Issue: 4-6 Pages: 617-628
- DOI
  10.1007/s00210-008-0312-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs2008
- Author(s)
  Maeda K, Sugiyama Y
- Journal Title
  
  Drug Metab Pharmacokinet 23
  
  Pages: 223-235
- NAID
  10021956066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans.2008
- Author(s)
  Kitamura.S, Maeda K, Sugiyama Y
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol. 377
  
  Pages: 617-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] ファーマコゲノミクス(総論)2008
- Author(s)
  前田和哉, 杉山雄一
- Journal Title
  
  DNAチップ/マイクロアレイ臨床応用の実際(遺伝子医学MOOK10)
  
  Pages: 336-349
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Involvement of multiple transporters in the hepatobiliary tr ansport of rosuvastatin2008
- Author(s)
  Kitamura S, Maeda K, Wang Y, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages: 2014-2023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin.2008
- Author(s)
  Kitamura S, Maeda K, Wang Y, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages: 2014-2023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] 薬物トランスポー夕ー : 臨床医療での意義とinvitro実験からの予測の留意点2007
- Author(s)
  前田和哉
- Journal Title
  
  薬剤学 67(1)
  
  Pages: 46-58
- Data Source
  KAKENHI-PROJECT-17790113
[Journal Article] Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.2007
- Author(s)
  Yamada A, Maeda K, Kamiyama E, Sugiyama D, Kondo T, Shiroyanagi Y, Nakazawa H, Okano T, Adachi M, Schuetz JD, Adachi Y, Hu Z, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 35
  
  Pages: 2166-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790119
[Journal Article] Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans2006
- Author(s)
  Yamashiro W, Maeda K, Hirouchi M, Adachi Y, Hu Z, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 34
  
  Pages: 1247-1254
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans2006
- Author(s)
  Ishiguro N, Maeda K, Kishimoto W, Saito A, Harada A, Ebner T, Roth W, Igarashi T, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 34(7)
  
  Pages: 1109-1115
- Data Source
  KAKENHI-PROJECT-17790113
[Journal Article] Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans2006
- Author(s)
  Yamashiro W, Maeda Km, Hirouchi M, Adachi Y, Hu Z, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 34(7)
  
  Pages: 1247-1254
- Data Source
  KAKENHI-PROJECT-17790113
[Journal Article] Drug-drug interaction between pitavastatin and various drugs via OATP1B12006
- Author(s)
  Hirano M, Maeda K, Shitara Y, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 34 (7)
  
  Pages: 1229-1236
- Data Source
  KAKENHI-PROJECT-17790113
[Journal Article] Uptake of Ursodeoxycholate and Its Conjugates by Human Hepatocytes : Role of Na^+-Taurocholate Cotransporting Polypeptide (NTCP), Organic Anion Transporting Polypeptide (OATP) 1B1 (OATP-C), and OATP1B3 (OATP8)2006
- Author(s)
  Maeda, K., Kambara, M., Tian, Y., Hofmann, A.F., Sugiyama, Y.
- Journal Title
  
  Molecular Pharmaceutics 3(1)
  
  Pages: 70-77
- Data Source
  KAKENHI-PROJECT-17790113
[Journal Article] オーバービュー:薬物トランスポーターの分子多様性、組織特異性、遺伝子多型2005
- Author(s)
  杉山雄一, 前田和哉
- Journal Title
  
  日本薬理学雑誌 124(4)
  
  Pages: 178-184
- NAID
  10016428606
- Data Source
  KAKENHI-PROJECT-17790113
[Presentation] Risk assessment of drug-induced intestinal toxicity with the use of human/animal crypt-derived intestinal cells2023
- Author(s)
  前田和哉
- Organizer
  日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] ヒト空腸スフェロイドを用いたセロトニン（5-HT）放出評価系の構築と薬剤誘導性悪心・嘔吐のリスク評価に向けた基礎検討2023
- Author(s)
  橋本芳樹、前田和哉、下村治、宮﨑貴寛、橋本真治、小田竜也、楠原洋之
- Organizer
  HAB研究機構第30回学術年会
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] 薬剤誘導性悪心・嘔吐のリスク評価に向けたヒト空腸幹細胞スフェロイドを用いたセロトニン放出評価系の構築2023
- Author(s)
  橋本芳樹、前田和哉、下村治、宮﨑貴寛、橋本真治、小田竜也、楠原洋之
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] 小腸crypt由来分化細胞を用いた消化管吸収予測系の開発2023
- Author(s)
  前田和哉
- Organizer
  HAB研究機構第30回学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] Challenges in extrapolation of in vitro experimental data to human intestinal absorption with crypt-derived intestinal cells2023
- Author(s)
  Kazuya Maeda
- Organizer
  7th Asia Pacific ISSX 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 薬剤誘導性悪心・嘔吐のリスク予測に向けた培養enterochromaffin細胞を用いたセロトニン放出評価系の開発2023
- Author(s)
  橋本芳樹、前田和哉、下村治、宮﨑貴寛、橋本真治、小田竜也、楠原洋之
- Organizer
  日本動物実験代替法学会第36回大会
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] ヒト/動物消化管crypt由来分化細胞を用いた消化管吸収・消化器毒性の予測　～今、できること、できないこと～2023
- Author(s)
  前田和哉
- Organizer
  第446回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] Development of the experimental systems with human crypt-derived intestinal cells for the prediction of intestinal drug absorption and drug-induced intestinal toxicity2023
- Author(s)
  前田和哉
- Organizer
  日本動物実験代替法学会第36回大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] DEVELOPMENT OF SEROTONIN RELEASE ASSAY WITH CULTURED ENTEROCHROMAFFIN CELLS FOR THE RISK ASSESSMENT OF EMESIS INDUCED BY TYROSINE KINASE INHIBITORS2023
- Author(s)
  Yoshiki Hashimoto, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27347
[Presentation] ヒト/動物消化管幹細胞由来分化細胞を用いた研究より見えてくる消化管吸収の多様性2023
- Author(s)
  前田和哉
- Organizer
  城西国際大学（JIU）定量的システム薬物動態・薬効解析研究室　第4回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] サル・イヌ・ヒト由来の部位別単離crypt培養系を用いた薬剤誘導性消化器毒性の基礎検討2022
- Author(s)
  橋本芳樹、前田和哉、道場一祥、下村治、宮﨑貴寛、橋本真治、森山亜紀子、小田竜也、楠原洋之
- Organizer
  医療薬学フォーラム2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] サル・ヒトcrypt由来消化管幹細胞培養系を用いたEGFRチロシンキナーゼ阻害薬による下痢発症リスクの評価2022
- Author(s)
  橋本芳樹、前田和哉、下村治、宮﨑貴寛、橋本真治、森山亜紀子、小田竜也、楠原洋之
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] ヒトcryptスフェロイド由来分化小腸細胞における部位選択的なトランスポーター機能発現および発現誘導に関する検討2022
- Author(s)
  道場一祥、前田和哉、下村治、宮崎貴寛、橋本真治、大原佑介、榎本剛史、小田竜也、楠原洋之
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ヒト空腸スフェロイド由来小腸上皮細胞の薬物代謝酵素・トランスポーター基質薬物のヒト消化管吸収性予測における特性評価2022
- Author(s)
  道場一祥、前田和哉、下村治、宮崎貴寛、橋本真治、大原佑介、榎本剛史、小田竜也、楠原洋之
- Organizer
  医療薬学フォーラム2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] サル・イヌ・ヒト由来の消化管部位別スフェロイド培養系を用いた薬剤誘導性消化器毒性の基礎検討2022
- Author(s)
  橋本芳樹, 前田和哉, 道場一祥, 森山亜紀子, 下村治, 宮﨑貴寛, 橋本真治, 小田竜也, 楠原洋之
- Organizer
  細胞アッセイ研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] MPSを用いた薬物動態・安全性評価への応用と課題2022
- Author(s)
  前田和哉
- Organizer
  第26回薬物動態談話会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ヒト空腸スフェロイド由来小腸上皮細胞の薬物代謝酵素・トランスポーター基質薬物のヒト消化管吸収性予測における特性評価2022
- Author(s)
  道場一祥、前田和哉、下村治、宮崎貴寛、橋本真治、大原佑介、榎本剛史、小田竜也、楠原洋之
- Organizer
  医療薬学フォーラム2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ヒト/サルcrypt由来の未分化・分化腸スフェロイドを用いたEGFRチロシンキナーゼ阻害薬による下痢発症リスクの評価2022
- Author(s)
  橋本芳樹、前田和哉、下村治、宮﨑貴寛、橋本真治、森山亜紀子、小田竜也、楠原洋之
- Organizer
  第5回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] ヒトcryptスフェロイド由来分化小腸細胞における部位選択的なトランスポーター機能発現および発現誘導に関する検討2022
- Author(s)
  道場一祥、前田和哉、下村治、宮崎貴寛、橋本真治、大原佑介、榎本剛史、小田竜也、楠原洋之
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 消化管幹細胞由来分化細胞の活用が拓く新たな薬物の消化管吸収・消化器毒性の評価法2022
- Author(s)
  前田和哉
- Organizer
  OYC Bio Symposium 2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] ヒト空腸幹細胞由来分化小腸上皮細胞を用いた薬物代謝酵素・トランスポーター基質薬物の消化管吸収特性評価2022
- Author(s)
  道場一祥、前田和哉、下村治、宮﨑貴寛、橋本真治、小田竜也、楠原洋之
- Organizer
  第29回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 薬物のヒト消化管吸収率の定量的予測のための新規ツール開発と予測法に関する考察2022
- Author(s)
  前田和哉
- Organizer
  第435回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 消化管組織幹細胞由来分化細胞の活用による消化管吸収の定量的予測に向けた取り組み2021
- Author(s)
  前田和哉
- Organizer
  薬物動態談話会9月例会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] ヒト手術残余検体由来の腸管幹細胞を用いた消化管吸収予測モデルの構築2021
- Author(s)
  前田和哉
- Organizer
  日本動物実験代替法学会第34回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 手術残余ヒト消化管組織を活用した医薬品の消化管吸収動態評価系の開発2021
- Author(s)
  道場一祥, 前田和哉, 栗盛洸, 榎本剛史, 下村治, 小田竜也, 楠原洋之
- Organizer
  医療薬学フォーラム2021
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] ヒト消化管組織および crypt由来組織幹細胞の利用による消化管吸収予測2021
- Author(s)
  前田和哉
- Organizer
  第425回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] ヒト空腸スフェロイド由来小腸上皮細胞の薬物代謝酵素・トランスポーター基質薬物のヒト消化管吸収特性評価における特性評価2021
- Author(s)
  道場一祥, 前田和哉, 栗盛洸, 榎本剛史, 下村治, 小田竜也, 楠原洋之
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] サル・イヌ由来の部位別単離crypt培養系を用いた薬剤誘導性消化器毒性の評価系の構築および基礎検討2021
- Author(s)
  橋本芳樹, 道場一祥, 森山亜紀子, 前田和哉, 楠原洋之
- Organizer
  日本薬物動態学会第36年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 3次元スフェロイド培養系を活用した消化管吸収評価系の構築に向けた基礎検討2021
- Author(s)
  道場一祥, 前田和哉, 楠原洋之
- Organizer
  第28回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] サル・イヌ・ヒト由来の部位別単離Crypt培養系を用いた薬剤誘導性消化器毒性の基礎検討2021
- Author(s)
  橋本芳樹, 前田和哉, 道場一祥, 森山亜紀子, 栗盛洸, 榎本剛史, 下村治, 小田竜也, 楠原洋之
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 3次元ヒト小腸スフェロイド培養系を活用した消化管吸収評価系の開発2021
- Author(s)
  道場一祥, 前田和哉, 栗盛洸, 榎本剛史, 下村治, 小田竜也, 楠原洋之
- Organizer
  日本薬物動態学会第36年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] マウス消化管crypt由来分化細胞を活用した消化管吸収評価系の構築に向けた基礎検討2021
- Author(s)
  道場一祥、前田和哉、楠原洋之
- Organizer
  細胞アッセイ研究会「細胞アッセイ技術の現状と将来」
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] マウス消化管組織幹細胞由来分化細胞を用いた消化管吸収評価系の構築に向けた基礎検討2021
- Author(s)
  道場一祥, 前田和哉, 楠原洋之
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 小腸crypt由来分化細胞を用いた消化管吸収予測系の開発2021
- Author(s)
  前田和哉
- Organizer
  第28回HAB研究機構学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] Characterization of the intestinal transport of drugs with human-derived tissue samples2020
- Author(s)
  Kazuya Maeda
- Organizer
  THE 16th SUGIYAMA LABORATORY RIKEN OPEN SYMPOSIUM
- Invited
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 摘出ヒト新鮮消化管検体を用いたUssing chamber法による取り込み/排出トランスポーターを介した薬物の消化管輸送特性の解析2020
- Author(s)
  道場一祥、前田和哉、栗盛洸、榎本剛史、下村治、小田竜也、楠原洋之
- Organizer
  第15回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] 医薬品のヒト消化管吸収率の予測に向けた手術残余ヒト消化管組織の有効活用2020
- Author(s)
  道場一祥、前田和哉、栗盛洸、榎本剛史、下村治、小田竜也、楠原洋之
- Organizer
  第14回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] マウス消化管crypt由来分化細胞培養系を活用した消化管における薬物輸送評価系の構築に向けた基礎検討2020
- Author(s)
  道場一祥、前田和哉、楠原洋之
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] 摘出ヒト新鮮消化管検体を用いた取り込み/排出トランスポーターを介した薬物輸送特性の解析および薬物のヒト消化管吸収率の予測2020
- Author(s)
  道場一祥、前田和哉、栗盛洸、榎本剛史、下村治、小田竜也、楠原洋之
- Organizer
  第27回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] Ussing chamber 法による摘出ヒト消化管検体を用いた薬物の消化管輸送特性の解析2020
- Author(s)
  道場一祥、前田和哉、栗盛洸、榎本剛史、下村治、小田竜也、楠原洋之
- Organizer
  日本薬物動態学会第35回年会
- Data Source
  KAKENHI-PROJECT-20H03402
[Presentation] Recent progress in newly-developed cell systems for the characterization of pharmacokinetic properties of drugs2020
- Author(s)
  Kazuya Maeda
- Organizer
  第15回杉山特別研究室（理研）公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] Current situation and future perspective of the quantitative prediction of drug-drug interaction risks2019
- Author(s)
  Kazuya Maeda
- Organizer
  International Symposium on drug-drug interaction and clinical rational drug usage
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] 新しい細胞・組織ソースを利用した薬物動態解析の最前線と今後の課題2019
- Author(s)
  前田和哉
- Organizer
  第407回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] ヒト肝臓キメラマウス(PXBマウス)由来肝細胞(PXB-cells)の作製由来凍結肝細胞ロットによるトランスポーター基質薬物の輸送活性の差異に関する検討2019
- Author(s)
  古屋詩乃、寺島花野、前田和哉、石田雄二、立野知世、楠原洋之
- Organizer
  第26回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] ヒト肝キメラマウスHu-Liver TK-NOGマウスによるトランスポーター基質のヒト肝胆系輸送の定量的評価に関する検討2018
- Author(s)
  寺島花野、前田和哉、米田直央、西脇恵、神村秀隆、末水洋志、楠原洋之
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] ヒト肝臓キメラマウス(PXBマウス）由来肝細胞(PXB-cells)を用いたトランスポーター基質薬物の胆汁排泄クリアランスのin vitro-in vivo予測の検討2018
- Author(s)
  寺島花野、前田和哉、石田雄二、立野知世、楠原洋之
- Organizer
  第25回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] ヒト肝臓キメラマウスHu-Liver TK-NOGマウスを用いたトランスポーター基質薬物の肝胆系輸送の評価2018
- Author(s)
  寺島花野、前田和哉、米田直央、西脇恵、神村秀隆、末水洋志、楠原洋之
- Organizer
  第25回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] Small-dosing clinical study: pharmacoki- netic, pharmacogeno-mic (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit Juice) profiles of five probes for OATP2B1 and BCRP.2017
- Author(s)
  Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
- Organizer
  15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Place of Presentation
  国立京都国際会館 (京都府京都市)
- Year and Date
  2017-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] The prediction of the relative importance of CYP3A/P-glycoprotein to the nonlinear intestinal absorption of drugs by advanced compartmental absorption and transit model.2017
- Author(s)
  Maeda K, Takano J, Bolger MB, Sugiyama Y.
- Organizer
  ASCPT 2017 Annual Meeting
- Place of Presentation
  Washington Marriott Wardman Park, Washington DC, US
- Year and Date
  2017-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝OATPおよびCYP3Aが関与する薬物間相互作用のPBPKモデル解析.2017
- Author(s)
  吉門崇, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Comparison of the expression and function of hepatic drug uptake transporters in hepatocytes (PXB-cells) derived from humanized-liver mice (PXB-mice) and human cryopreserved hepatocytes2017
- Author(s)
  Hanano Terashima, Kazuya Maeda, Yuji Ishida, Chise Tateno, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会　第32回年会
- Data Source
  KAKENHI-PROJECT-17H04006
[Presentation] Current Status and Future Challenges of the Prediction of Pharmacokinetic Alterations in Special Population.2016
- Author(s)
  前田和哉
- Organizer
  第７回杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  理化学研究所（神奈川県横浜市)
- Year and Date
  2016-02-16
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Prediction of drug interactions at transporters.2016
- Author(s)
  Maeda K.
- Organizer
  11th International ISSX meeting
- Place of Presentation
  Busan Convention and Exhibition Center, Busan, Korea
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターと薬物代謝酵素が関与する肝消失律速過程の解析.2016
- Author(s)
  吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本動物実験代替法学会第29回大会
- Place of Presentation
  九州大学百年講堂（福岡県博多区）
- Year and Date
  2016-11-17
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 内在性基質の変動を利用したOATPを介した薬物間相互作用の定量的評価法の開発.2016
- Author(s)
  楠原洋之, 吉門崇, 前田和哉, 寺島花野, 中山丈史, 吉田美和, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物の肝胆系輸送の重要性・その評価の現状と将来展望.2016
- Author(s)
  前田和哉
- Organizer
  とっとりバイオフロンティア人材育成セミナー
- Place of Presentation
  鳥取大学（鳥取県鳥取市）
- Year and Date
  2016-12-20
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] クロピドグレルの関与する薬物間相互作用のカセットドーズ臨床試験に基づいたメカニズム解析とin vitro試験に基づいた予測.2016
- Author(s)
  Soo-Jin Kim, 吉門崇, 家入一郎, 前田和哉, 木村美由紀, 入江伸, 楠原洋之, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 創薬における薬物相互作用リスクの定量的評価法の現状とレギュラトリーガイドライン.2016
- Author(s)
  前田和哉
- Organizer
  医療薬学フォーラム2016
- Place of Presentation
  びわ湖ホール（滋賀県大津市）
- Year and Date
  2016-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] OATPs/CYP3A dual基質の薬物相互作用試験に基づいた肝消失律速過程の解析.2016
- Author(s)
  吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] In vitro estimation of unbound hepatocyte-to- medium concentration ratios (Kp,uu) of statins considering the membrane potential- dependent passive diffusion.2016
- Author(s)
  Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 相互作用ガイドラインを使う前に知っておきたい基礎知識.2016
- Author(s)
  前田和哉
- Organizer
  第20回薬物動態談話会セミナー
- Place of Presentation
  クロスウェーブ府中（東京都府中市）
- Year and Date
  2016-08-24
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Real-time Imaging of Hepatic Uptake and Biliary Excretion of Drugs.2016
- Author(s)
  Maeda K.
- Organizer
  AMED-DFG Workshop“Functional Metabolic Imaging”
- Place of Presentation
  Schloss Hohentubingen , Tubingen, Germany
- Year and Date
  2016-03-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝臓における薬物間相互作用の解析～IVIVEはどの程度可能か？～2016
- Author(s)
  前田和哉
- Organizer
  第373回CBI学会講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2016-06-02
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Identification of GCDCA-S as endogenous biomarkers for OATP1B1 and OATP1B3 in healthy subject.2016
- Author(s)
  Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clopidogrel-mediated drug-drug interaction on CYP2C8 and OATP1B1: in vitro inhibitory effect and in vivo clinical study.2016
- Author(s)
  Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Quantitative prediction of hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 using relative activity factor-based scaling approach.2016
- Author(s)
  Izumi S, Nozaki Y, Komori T, Maeda K, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターを介したDDIリスク予測を考える上での留意点.2015
- Author(s)
  前田和哉
- Organizer
  第363回CBI学会研究講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2015-06-11
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 数理モデルを活用した集団における薬効・副作用発現確率の定量的予測～docetaxel誘発性血液毒性を例にとって～.2015
- Author(s)
  前田和哉
- Organizer
  第21回創剤フォーラム若手研究会
- Place of Presentation
  東京大学薬学部（東京都文京区）
- Year and Date
  2015-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Comparative Evaluation of Unbound Intracellular-Medium (Plasma) Concentration Ratios (Kp,uu) of Poorly-Metabolized Anionic Drugs Using Rat and Human Hepatocytes.2015
- Author(s)
  Nakada T, Ikejiri K, Toshimoto K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 日米欧の薬物相互作用ガイダンス/ガイドラインのポイントおよび今後の課題.2015
- Author(s)
  前田和哉
- Organizer
  第36回日本臨床薬理学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] A clinical drug interaction study using hepatic OATPs/CYP3A dual substrates: analysis of the rate-determining process based on the extended clearance concept.2015
- Author(s)
  Yoshikado T, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Maeda K, Kusuhara H, Furihata K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝取り込みトランスポーターOATPs および代謝酵素CYP3A4 のdual 基質薬の関与する薬物間相互作用の臨床解析.2015
- Author(s)
  杉山雄一, 吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Ussing chamberを用いた薬物の消化管組織透過性に関する担体輸送機構の検討2015
- Author(s)
  中山丈史、前田和哉、Paul A. Dawson、楠原洋之
- Organizer
  第22回HAB研究機構学術年会
- Place of Presentation
  昭和大学（東京都）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Clarification of the mechanism of clopidogrel-mediated drug-drug interaction on the pharmacokinetics of repaglinide in a clinical cassette small-dose study.2015
- Author(s)
  Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] HCV治療薬の肝取り込みにおけるOATP分子種の重要性の検討2014
- Author(s)
  尾上朋弘、前田和哉、楠原洋之
- Organizer
  第22回肝病態生理研究会
- Place of Presentation
  都市センターホテル（東京都）
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Special populationにおける薬物動態予測の現状（総論）2014
- Author(s)
  前田和哉
- Organizer
  第357回CBI学会研究講演会
- Place of Presentation
  東京都文京区、東京大学山上会館2階　大会議室
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝異物排泄におけるトランスポーターの個人間変動とＰＥＴを用いたin vivo輸送能力の評価2014
- Author(s)
  楠原洋之、前田和哉
- Organizer
  第３５回日本臨床薬理学会学術集会
- Place of Presentation
  松山
- Year and Date
  2014-12-05
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Quantitative analysis of the boosting effect of ritonavir on the pharmacokinetics of saquinavir by using physiologically-based pharmacokinetic modeling2014
- Author(s)
  Kazuya Maeda
- Organizer
  2014 Annual Meeting of KSAP
- Place of Presentation
  Seoul National University　(Seoul, Korea)
- Year and Date
  2014-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] 肝異物排泄におけるトランスポーターの重要性2014
- Author(s)
  楠原洋之、前田和哉
- Organizer
  第３回日本くすりと糖尿病学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2014-11-03
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Quantitative prediction of the effect of multiple pharmacokinetic interactions using physiologically-based pharmacokinetic (PBPK) models through the analyses with Cluster Newton Method2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  28th JSSX Annual Meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 肝臓内非結合型薬物濃度を見積もるための簡便なin vitro実験法の提案2013
- Author(s)
  杉山雄一，池尻和明，前田和哉，楠原洋之
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Application of a Novel Computational Method to Estimate Feasible Solution Spaces for Determining Multiple Parameters in Physiologically-based Pharmacokinetic (PBPK) Model2013
- Author(s)
  Maeda K, Yoshida K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Ontario, Canada
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Quantitative prediction of drug-drug interactions involving repaglinide, gemfibrozil, and itraconazole using a new computational method to estimate feasible solution spaces2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  2nd HD physiology International Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] PARAMETER OPTIMIZATION IN PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL FOR THE PREDICTION OF TRANSPORTER-MEDIATED DRUG-DRUG INTERACTIONS WITH A NEW GLOBAL PARAMETER OPTIMIZATION METHOD.2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y.
- Organizer
  ASCPT 2013 Annual Meeting
- Place of Presentation
  JW Marriott, Indianapolis, Indiana, US
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Precise estimation of the contribution of CYP enzymes to overall metabolism from in vivo information: application of Cluster Newton Method2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Sugiyama Y, Konagaya A
- Organizer
  CBI学会2013年大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 肝OATPを介した薬物間相互作用のPBPKモデルを用いた解析－腸肝循環を考慮した合理的なモデルへの発展－2013
- Author(s)
  吉門崇，吉田健太，中田智久，小谷直生，前田和哉，杉山雄一
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Application of In Vitro Assays and PBPK Modelling to Predict Intracellular Hepatic Drug Concentrations2013
- Author(s)
  Maeda K and Sugiyama Y
- Organizer
  2013 AAPS Workshop on Drug Transporters
- Place of Presentation
  Washington, USA(招待講演)
- Year and Date
  2013-03-20
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] 薬物とトランスポーターの相互作用による薬効・副作用発現の変動とその予測にむけて2013
- Author(s)
  前田和哉
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] 臨床試験における薬物代謝酵素、トランスポーターの遺伝子多型の影響を予測する：臨床試験による確認を最少にできるか？2013
- Author(s)
  前田和哉
- Organizer
  第344回CBI学会研究講演会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] トランスポーターを介した薬物間相互作用予測のための腸肝循環およびIn vitro膜透過性を考慮した生理学的薬物速度論モデルの提案2013
- Author(s)
  吉門崇，吉田健太，前田和哉，杉山雄一
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物トランスポーター分子の機能がヒトin vivo薬物動態に与えるインパクトの定量的予測2013
- Author(s)
  前田和哉
- Organizer
  第７回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Factors for the inter-individual differences in the pharmacokinetics of OATP substrates2013
- Author(s)
  Maeda K and Sugiyama Y
- Organizer
  The 4th International conference clinically relevant drug transporters 2013
- Place of Presentation
  Berlin, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Prediction of Transporter-mediated DDIs involving hepatic transporters2013
- Author(s)
  Maeda K and Sugiyama Y
- Organizer
  The 16th International conference on drug-drug interactions
- Place of Presentation
  Seattle, WA, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Application of a novel global parameter optimization algorithm to appropriate parameters in physiologically-based pharmacokinetic (PBPK) model2012
- Author(s)
  前田和哉
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Roles of Drug Transporters in the Pharmacological and Adverse Reactions of Drugs2012
- Author(s)
  前田和哉
- Organizer
  The 3rd International Lhasa symposium on New Horizons in Toxicity Prediction
- Place of Presentation
  Cambridge, UK
- Year and Date
  2012-09-06
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 肝臓内への蛋白非結合型薬物の濃縮度の定量的見積りに向けたin vitro実験系の構築2012
- Author(s)
  池尻和明、前田和哉、杉山雄一
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸市
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Threoretical consideration of the mechanisms of the ethnic difference in the pharmacokinetics of various statins from the viewpoint of OATP1B1 -mediated clearance2012
- Author(s)
  Maeda K and Sugiyama Y
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀、東京都
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Construction of physiologically-based pharmacokinetic models explaining drug-drug interactions via the inhibition of organic anion transporting polypeptides (OATPs)2012
- Author(s)
  Yoshikado T, Maeda K, Nakada T, Kotani N, Yoshida K, Sugiyama Y.
- Organizer
  19th Microsomes and Drug Oxidations (MDO) and 12th European ISSX Meeting
- Place of Presentation
  Grand Hotel Huis ter Duin, Noordwijk aan Zee, the Netherlands
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clinical DDI study for demonstrating the importance of OATP2B l in the intestinal uptake of celiprolol and fexofenadine by the coadministration of atorvastatin2012
- Author(s)
  Fukizawa S, Maeda K, Kusuhara H, Ieiri l, Hirota T, Gotanda, K, Sugiyama Y
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀、東京都
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] The Importance of OATP Transporters in the Clinical Pharmacokinetics of Anionic Drugs2012
- Author(s)
  前田和哉
- Organizer
  International Conference on Frontiers in Pharmaceutical Sciences: Global Perspectives
- Place of Presentation
  Rhode Island, USA
- Year and Date
  2012-09-30
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Ritonavirを用いたboosting併用療法を再現する生理学的薬物速度論モデルの構築と相互作用機序の定量的考察2012
- Author(s)
  前田和哉、小谷直生、家入一郎、安東幸恵、木村美由紀、入江伸、山根尚恵、奥薗剛、杉山雄一
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸市
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] The Importance of OATP Transporters in the Clinical Pharmacokinetics of Anionic Drugs2012
- Author(s)
  Maeda K
- Organizer
  1st International Conference of "Frontiers in Pharmaceutical Sciences : Global Perspectives (FPS-GP1)
- Place of Presentation
  Rhode Island, USA(招待講演)
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] The prediction of the intestinal availability of CYP3A4 and/or p-gp substrate drugs from the in vitro measurements based on mathematical modeling2012
- Author(s)
  Takano J, Maeda K, and Sugiyama Y
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀、東京都
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] ブースティングによる薬物バイオアベイラビリティの改善2012
- Author(s)
  前田和哉、杉山雄一
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  北海道大学、札幌市(招待講演)
- Year and Date
  2012-07-04
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] (1) Model-based prediction of intestinal availability of substrate drugs for p-gp and/or CYP3A4, (2) Impact of intestinal uptake and efflux transporters on the non-linear intestinal absorption of drugs.2012
- Author(s)
  Maeda K
- Organizer
  The 15th International Conference on Drug-Drug Interactions (DDI-2012)
- Place of Presentation
  Seattle, USA(招待講演)
- Year and Date
  2012-06-11
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Quantitative analyses of drug-drug interactions between statins and cyclosporine A using physiologically-based pharmacokinetic models2012
- Author(s)
  Takashi Yoshikado, Kazuya Maeda, Tomohisa Nakada, Yoshihisa Shitara, Kenta Yoshida, Yuichi Sugiyama
- Organizer
  27th JSSX Annual Meeting
- Place of Presentation
  Chiba, Japan
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝臓内非結合型薬物濃度を予測するためのin vitro実験系の検討2012
- Author(s)
  池尻和明、前田和哉、杉山雄一
- Organizer
  第20回肝病態生理研究会
- Place of Presentation
  金沢市
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Sandwich培養肝細胞を用いた薬物の胆汁排泄評価に与える取り込みトランスポーターの発現変動の影響2012
- Author(s)
  前田和哉、小谷直生、渡辺貴夫、平松万里子、楠原洋之、杉山雄一
- Organizer
  第20回肝病態生理研究会
- Place of Presentation
  金沢市
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Evaluation of the protein unbound inhibitor concentration in the liver for the accurate prediction of drug interactions2012
- Author(s)
  Ikejiri K, Maeda K, Kusuhara H and Sugiyama Y
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀、東京都
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] ABCG2 (BCRP) 421 C>Aが薬物の消化管吸収に及ぼす影響の定量的考察2012
- Author(s)
  田中裕太.北村嘉章、前田和哉、杉山雄一
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸市
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] The importance of organic anion transporting polypeptide (OATP) 2B1 to the intestinal drug absorption2011
- Author(s)
  Shinya Fukizawa, Kazuya Maeda, Mayuko Miyagawa, Ichiro Ieiri, Miyuki Kimura, Shin Irie, Kazuhide Iwasaki, Yuichi Sugiyama
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Quantitative prediction of clinically relevant transporter-mediated drug-drug interactions from in vitro data2011
- Author(s)
  Kenta Yoshida、Kazuya Maeda、YuichiSugiyama
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Quantitative evaluation of transporter-mediated drug-drug interactions based on a clearance concept and in vitro kinetic parameters2011
- Author(s)
  Kazuya Maeda
- Organizer
  IQ/FDA Drug-drug Interaction Prediction Workshop
- Place of Presentation
  Silver Spring, MD, USA
- Year and Date
  2011-06-06
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] The importance of organic anion transporting polypeptide(OATP) 2B1 to the intestinal drug absorption2011
- Author(s)
  Shinya Fukizawa、Kazuya Maeda、Mayuko Miyagawa、Ichiro Ieiri、Miyuki Kimura、Shin Irie、Kazuhide Iwasaki、Yuichi Sugiyama
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] The use of hepatocyte cell models to investigate drug uptake transporters2011
- Author(s)
  Kazuya Maeda
- Organizer
  HepaRG Workshop 2011
- Place of Presentation
  Rennes, France(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 薬物間相互作用を定量的に予測するための考え方:数理モデルを通した理解2011
- Author(s)
  前田和哉
- Organizer
  第314回CBI研究講演会
- Place of Presentation
  東京
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] Quantitative evaluation of transporter-mediated drug-drug interactions based on a clearance concept and in vitro kinetic parameters2011
- Author(s)
  Kazuya Maeda
- Organizer
  IQ/FDA Drug-drug Interaction Prediction Workshop
- Place of Presentation
  Silver Spring, MD, USA(招待講演)
- Year and Date
  2011-06-06
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 薬物間相互作用を定量的に予測するための考え方:数理モデルを通した理解2011
- Author(s)
  前田和哉
- Organizer
  第314回 CBI研究講演会
- Place of Presentation
  東京
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] The use of hepatocyte cell models to investigate drug uptake transporters2011
- Author(s)
  Kazuya Maeda
- Organizer
  Hepa RG Workshop 2011
- Place of Presentation
  Rennes, France
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ドセタキセルによる重篤な好中球減少症の発症におけるOATP1B3,MRP2の役割2010
- Author(s)
  山田哲裕、前田和哉、清谷一馬、莚田泰誠、中村祐輔、杉山雄一
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] ドセタキセル誘発性好中球減少症のリスクを決定するOATP1B3,MRP2の役割2010
- Author(s)
  山田哲裕、前田和哉、清谷一馬、莚田泰誠、中村祐輔、杉山雄一
- Organizer
  第5回トランスポーター研究会年会
- Place of Presentation
  東京
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] Theoretical Prediction of transporter-mediated drug-drug interaction2010
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/AAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Use of Human Cryopreserved Hepatocytes for the Prediction of the Hepatobiliary Transport of Drugs2010
- Author(s)
  Kazuya Maeda
- Organizer
  Hepatocyte Expert Program 2010
- Place of Presentation
  東京
- Year and Date
  2010-06-28
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] ドセタキセルに起因する好中球減少症を決定するOATP1B3,MRP2の役割に関する解析2010
- Author(s)
  山田哲裕、前田和哉、清谷一馬、莚田泰誠、中村祐輔、杉山雄一
- Organizer
  第18回肝病態生理研究会
- Place of Presentation
  山形
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] Theoretical Prediction of transporter-mediated drug-drug interaction2010
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/RAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  7^<th> Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ROLE OF MURINE Oatp1a4 IN THE HEPATIC UPTAKE OF DRUGS IN MICE2009
- Author(s)
  Junichi Takano, Kazuya Maeda and Yuichi Sugiyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  福岡
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トランスポーターを介した薬物間相互作用による血漿中・組織中濃度の変動のin vitro実験に基づく定量的予測法の検討2009
- Author(s)
  前田和哉、北村吏司、杉山雄一
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009
- Author(s)
  Kazuya Maeda, Yuichi Sugiyama
- Organizer
  7th Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ROLE OF MURINE Oatpla4 IN THE HEPATIC UPTAKE OF DRUGS IN MICE2009
- Author(s)
  Junichi Takano, Kazuya Maeda, Yuichi Sugiyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  福岡
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] ヒト薬物トランスポーターの遺伝子多型がグリチルリチンの薬物動態に与える影響2009
- Author(s)
  前田和哉, 滝川一, 出堀泰之, 江頭徹, 杉山雄一
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-20018006
[Presentation] QUANTITATIVE PREDICTION OF THE CLEARANCE PATHWAYS OF TRANSPORTER SUBSTRATES FROM IN VITRO EXPERIMENTS2009
- Author(s)
  Kazuya Maeda and Yuichi Sugiyama
- Organizer
  7^th Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 薬物トランスポーターの遺伝子変異がドセタキセルによる重篤な骨髄抑制の発症頻度に影響を与えるメカニズムの検討2009
- Author(s)
  山田哲裕、前田和哉、清谷一馬、筵田泰誠、中村祐輔、杉山雄一
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] ヒト凍結肝細胞を利用した薬物の肝取り込み・胆汁排泄の予測法2009
- Author(s)
  前田和哉
- Organizer
  シンポジウム「医薬品探索・開発のための細胞アッセイ技術」
- Place of Presentation
  東京
- Year and Date
  2009-01-08
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] ドセタキセル誘導性の骨髄抑制の重篤度を決定付ける薬物トランスポーターの重要性2009
- Author(s)
  山田哲裕、前田和哉、清谷一馬、筵田泰誠、中村祐輔、杉山雄一
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21790145
[Presentation] Prediction of in vivo hepatic and renal clearance of transporter substrates from in vitro uptake clearance using isolated hepatocytes and kidney slices.2008
- Author(s)
  Maeda K, Watanabe T, Watanabe T, Debori Y, Kusuhara H and Sugiyama Y.
- Organizer
  2nd Asian-Pasific ISSX meeting
- Place of Presentation
  上海, 中国
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] Prediction of in vivo hepatic and renal clearance of transpcrter substrates from in vitro uptake clearance using isolated hepatocytes and kidney slices2008
- Author(s)
  Maeda K, Watanabe T, Watanabe T, Debori Y, Kusuhara H and Sugiyama Y.
- Organizer
  2^<nd> Asian-Pasific ISSX meeting
- Place of Presentation
  上海、中国
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] SEARCH AND VALIDATION OF IN VIVO PROBE DRUGS FOR FUNCTIONAL ANALYSIS OF OAT1 AND OAT3 IN HUMANS2008
- Author(s)
  Tian Y, Maeda K, Kumagai Y, Kondo T, Kusuhara H and Sugiyama Y
- Organizer
  日本薬物動態学会第23回年会
- Place of Presentation
  熊本
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 遊離肝細胞、腎スライスを用いた医薬品の消失の肝腎振り分けのin vitro 予測法の検討2008
- Author(s)
  渡辺友子, 前田和哉, 渡邉貴夫, 出掘泰之, 近藤恒徳, 楠原洋之, 杉山雄一
- Organizer
  第15回HAB研究機構学術年会
- Place of Presentation
  東京
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] 遊離肝細胞を用いたin vitro取り込み実験の結果に基づくin vivo肝クリアランスの予測の検討2008
- Author(s)
  前田和哉、渡辺友子、渡辺貴夫、出堀泰之、楠原洋之、杉山雄一
- Organizer
  第16回肝病態生理研究会
- Place of Presentation
  松山
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] 遊離肝細胞を用いたin vitro 取り込み実験の結果に基づくin vivo肝クリアランスの予測の検討2008
- Author(s)
  前田和哉, 渡辺友子, 渡辺貴夫, 出堀泰之, 楠原洋之, 杉山雄一
- Organizer
  第16回肝病態生理研究会
- Place of Presentation
  松山
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] 薬物トランスポーターが関与する薬物間相互作用の事例解析と予測法の構築へ向けて2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  第12回薬物動態談話会セミナー
- Place of Presentation
  つくば
- Year and Date
  2008-08-21
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] トラとスポーターの遺伝子多型が薬物動態・薬効に与えるインパクト〜OATP1B1, BCRPを中心に〜2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  日本臨床薬理学会第29回年会
- Place of Presentation
  東京
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20018006
[Presentation] トランスポーターレベルの薬物間相互作用:in vitro実験データと臨床データの対応付け2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  CBI研究講演会
- Place of Presentation
  東京
- Year and Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] The multiplicaity of transporters involved in hepatic uptake and efflux in humans and their contribution to the overall biliary clearance2008
- Author(s)
  Maeda K, et. al.
- Organizer
  The 27th symposium on Biomembrane-Drug Interaction
- Place of Presentation
  Kyoto
- Year and Date
  2008-11-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] トランスポーターレベルめ薬物間相互作用:in vitro実験データと臨床デー汐の対応付け2008
- Author(s)
  前田和哉、杉山雄一
- Organizer
  CBI研究講演会
- Place of Presentation
  東京
- Year and Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 遊離肝細胞、腎スライスを用いた医薬品の消失の肝賢振り分けのinvitro予測法の検討2008
- Author(s)
  渡辺友子、前田和哉、渡邉貴夫、出掘泰之、近藤恒徳、楠原洋之、杉山雄一
- Organizer
  第15回HAB研究機構学術年会
- Place of Presentation
  東京
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] 抗ヒスタミン薬Fexofenadineの肝輸送に関与するトランスポーターの同定2007
- Author(s)
  前田和哉, ほか
- Organizer
  第15回肝病態生理研究会
- Place of Presentation
  東京発,表場所
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Identification of Transporters involved in the Hepatic Transport of Anti-Histamine Drug, Fexofenadine2007
- Author(s)
  Maeda K, et. al.
- Organizer
  15th Japanese Study Group for the Pathophysiology of the liver
- Place of Presentation
  Tokyo
- Year and Date
  2007-05-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Physiologically based pharmacokinetic (PBPK) modeling for predicting transporter-mediated drug disposition in humans.2007
- Author(s)
  Watanabe T, Kusuhara H, Maeda, K and Sugiyama Y.
- Organizer
  The 8th International ISSX Meeting
- Place of Presentation
  仙台
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] 抗ヒスタミン薬Fexofenadineの肝輸送に関与するトランスポーターの同定2007
- Author(s)
  前田和哉ほか
- Organizer
  第15回肝病態生理研究会
- Place of Presentation
  東京
- Year and Date
  2007-05-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] トランスポーターを組み入れた生理学的薬物速度論モデリングによるヒトにおける薬物動態の予測と解析2007
- Author(s)
  渡邉貴夫, 楠原洋之, 前田和哉, 杉山雄一
- Organizer
  第15回肝病態生理研究会
- Place of Presentation
  東京
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-19790119
[Presentation] ヒトにおける薬物の肝取り込み、排泄に関わるトランスポーターの多様性、寄与率の評価2005
- Author(s)
  前田和哉ほか
- Organizer
  第27回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都
- Year and Date
  2005-11-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] トランスポーターが関与する薬物間相互作用のパラメータ許容解分布推定法による解析
- Author(s)
  吉田健太、前田和哉、楠原洋之、小長谷明彦、杉山雄一
- Organizer
  第21回肝病態生理研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 肝臓のトランスポーターについて
- Author(s)
  楠原洋之、前田和哉
- Organizer
  第３１回日本TDM学会・学術大会
- Place of Presentation
  東京
- Year and Date
  2014-05-31 – 2014-06-01
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Clinical Importance of Transporter-mediated Drug-Drug Interactions: Basics and Applications of Evidence-based Decision Making
- Author(s)
  Kazuya Maeda
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Hepatic Organic Cation Transporter 1 (OCT1) Regulates the Hepatic Clearance of Triptans, But Not Beta-blockers
- Author(s)
  Xuan Zhang , Kazuya Maeda, Hiroshi Suzuki, Hiroyuki Kusuhara
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] ACAT modelを活用した薬物の非線形な消化管吸収動態におけるCYP3A, P-gpの寄与の定量的解析
- Author(s)
  高野順市, 前田和哉, 杉山雄一
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮ソニックシティ（さいたま市大宮区）
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] Demonstration and Prediction of Clinical Importance of Drug Transporters as Determinants of Hepatic Clearance of Anionic Drugs
- Author(s)
  前田和哉
- Organizer
  5th Asia Pasific ISSX meeting
- Place of Presentation
  Tianjin, China
- Year and Date
  2014-05-10 – 2014-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-25670071
[Presentation] Integration of Novel Microdosing Studies with Mechanistic Modeling to Understand Impact of Transporter-Metabolism Interplay
- Author(s)
  Kazuya Maeda
- Organizer
  Gordon Research Conference “Drug Metabolism”
- Place of Presentation
  Holderness School (Holderness, NH, USA)
- Year and Date
  2014-07-06 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] 薬物動態の予測におけるヒト組織活用の意義
- Author(s)
  前田和哉
- Organizer
  第４回レギュラトリーサイエンス学会学術大会
- Place of Presentation
  東京都千代田区
- Year and Date
  2014-09-04 – 2014-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-25670071
[Presentation] 機械学習を用いた9つの主要なin vivo薬物クリアランス経路のin silico予測
- Author(s)
  年本広太、若山直美、堀田駿、前田和哉、石田貴士、秋山泰、杉山雄一
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  神奈川県横浜市、横浜国立大学
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] CHARACTERIZATION OF THE SECRETORY TRANSPORT OF DRUGS IN THE MOUSE SMALL INTESTINE USING USSING CHAMBER SYSTEM
- Author(s)
  Takeshi Nakayama, Kazuya Maeda, Shinya Fukizawa, Yukio Kato, Paul A. Dawson, Hiroyuki Kusuhara
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24689009
[Presentation] CLINICAL EVALUATION OF OATPs AND MRP2 ACTIVITY USING POSITRON EMISSION TOMOGRAPHY (PET) WITH [11C]DEHYDROPRAVASTATIN
- Author(s)
  Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Establishing a versatile analysis method of drug-drug interactions with the physiologically-based pharmacokinetic model using the Cluster Newton Method.
- Author(s)
  Toshimoto K, Yoshida K, Yoshikado T, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Translational Clinical Research of OATPs and MRP2 Activity Using Positron Emission Tomography (PET) with 11C-Dehydropravastatin.
- Author(s)
  Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
- Organizer
  World Molecular Imaging Congress 2014
- Place of Presentation
  Soul, Korea
- Year and Date
  2014-09-17 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24229002
[]

1. KUSUHARA Hiroyuki (00302612)

# of Collaborated Projects: 8 results

# of Collaborated Products: 36 results
2. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 6 results

# of Collaborated Products: 98 results
3. WATANABE Yasuyosi (40144399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. HAYASHI Hisamitsu (10451858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ONUKI Reko (70361607)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 家入一郎 (60253473)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
7. 吉門崇 (70535096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
8. 水野忠快 (90736050)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 小田竜也 (20282353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
10. KUMAGAI Yuji (40215017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SUWA Toshio (20383664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HISAKA Akihiro (80420206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MASUJIMA Tsutomu (10136054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIRONO Shuichi (30146328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHITARA Yoshihisa (00306656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKIKAWA Hajime (70197226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 新垣友隆 (60643187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 伊藤澄人 (20728969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 草間真紀子 (80313146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小野俊介 (40345591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 赤沢学 (80565135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 門田佳子 (20568951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 木村啓志 (40533625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 西川昌輝 (40843149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 加藤将夫 (30251440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 出口芳春 (40254255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. IJUIN Ryosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 藤田朋恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 梶本哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maeda Kazuya 前田 和哉

MAEDA Kazuya 前田 和哉

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Construction of the novel evaluation systems and the methodologies for quantitative risk assessment of drug-induced intestinal toxicityPrincipal Investigator

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Establishment of the novel experimental systems with human freshly-isolated intestinal tissues for the accurate prediction of intestinal drug absorption in humansPrincipal Investigator

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Precise quantative prediction of complex drug-drug interactions with the use of human liver chimeric micePrincipal Investigator

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Mitigation of the liver injury based on the regulation of membrane transport in hepatic stellate cellsPrincipal Investigator

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Analysis of pharmacokinetics and toxicological effects of drugs by quantitative estimation of human biliary excretion of drugs at a single cell levelPrincipal Investigator

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Quantitative prediction of the bioavailability of drugs based on the activities of dexofication enzymes/transportersPrincipal Investigator

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Role of drug transporters in the anticancer drug-induced hematotoxicityPrincipal Investigator

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Maeda Kazuya 前田和哉

MAEDA Kazuya 前田和哉

[Book] 創薬技術の革新マイクロドーズからPET分子イメージングへの新展開(編集杉山雄一、山下伸二、栗原千絵子)(薬物動態関連遺伝子多型による薬物動態の変動予測法の開発)2010