NAGAI Naoko 永井尚子

… Alternative Names

永井尚子ナガイナオコ

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Researcher Number	00367799
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 分子医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 愛知医科大学, 分子医科学研究所, 助教 2021: 愛知医科大学, 付置研究所, 助教 2016: 愛知医科大学, 分子医科学研究所, 助教 2012: 愛知医科大学, 付置研究所, 助教 2010 – 2012: 愛知医科大学, 分子医科学研究所, 助教 2006 – 2008: 愛知医科大学, 分子医科学研究所, 助教 2005 – 2006: 愛知医科大学, 分子医科学研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Pathological medical chemistry / Functional biochemistry Except Principal Investigator Experimental pathology / Biological Sciences
Keywords	Principal Investigator ヘパラン硫酸 / レプチン / へパラン硫酸 / エネルギー代謝 / 糖鎖 / 上衣細胞 / 血液脳関門 / レプチン送達 / 視床下部 / レプチンシグナル伝達 … More / ビオチン化タンパク質 / ビオチンクロスリンカー標識ヘパリン / 細胞表面受容体 / レプチン受容体 / 褐色脂肪組織 / 甲状腺 / 甲状腺ホルモン / Ucp1 / 褐色脂肪細胞 / FGF21 / Hs6st2 / 代謝 / 糖鎖生物学 / 脳神経疾患 / 酵素 / 細胞内局在 / アミロイドβ前駆体タンパク質 / ヘパラン硫酸硫酸基転移酵素 / βセクレターゼ / アルツハイマー病 / ヘパラン硫酸60-硫酸基転移酵素 … More Except Principal Investigator 細胞外マトリックス / プロテオグリカン / コンドロイチン硫酸 / グリコサミノグリカン / 創傷治癒 / バーシカン / 腫瘍増殖 / 間質 / 腫瘍微小環境 / 細胞外微小環境 / 腫瘍 / がん微小環境 / 遺伝子改変マウス / Mutant mouse / Glycosaminoglycans / Proteoglycans / Chondroitin sulfate / Concentration gradient / Morphogen / Cell growth factors / Heparan sulfate / コンドロイチン / 形態形成因子(モルフォゲン) / 遺伝子欠損マウス / 濃度勾配 / 形態形成因子 / 細胞増殖因子 / ヘパラン硫酸 / ノックアウトマウ / 微小環境 / ノックアウトマウス / コンディショナルノックアウトマウス Less

脳へのレプチン送達制御におけるへパラン硫酸機能の解明Principal Investigator
- Principal Investigator
  
  永井尚子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Elucidation of the control mechanism of leptin signal transduction by hypothalamic heparan sulfatePrincipal Investigator
- Principal Investigator
  
  永井尚子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Role of proteoglycans in diseases: Regulation of cell behavior and maintenance of tissue structure
- Principal Investigator
  
  WATANABE Hideto
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Aichi Medical University
Roles of chondroitin sulfate proteoglycan in maintenance of tissue structure and its remodeling under pathological conditions
- Principal Investigator
  
  WATANABE Hideto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Aichi Medical University
Elucidation of the mechanism involved in energy metabolic regulation by heparan sulfatePrincipal Investigator
- Principal Investigator
  
  NAGAI Naoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Aichi Medical University
Elucidation of the role of heparan sulfate 6O-sulfotransferase to the progression of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  NAGAI Naoko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Aichi Medical University
Spatio-temporal regulation of morphogenesis by heparan sulfate chains
- Principal Investigator
  
  KIMATA Koji
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Medical University

All 2023 2017 2016 2015 2013 2012 2011 2010 2008 2007 2004 Other

All Journal Article Presentation Book

[Book] 生物機能モデルと新しいリソース・リサーチツール2011
- Author(s)
  永井尚子
- Publisher
  木全弘治株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-22590296
[Book] 生物機能モデルと新しいリソース・リサーチツール2011
- Author(s)
  永井尚子
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-22590296
[Journal Article] Knockout of the intellectual disability-linked gene <i>Hs6st2</i> in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory2023
- Author(s)
  Moon Sohyun、Lee Hiu Ham、Archer-Hartmann Stephanie、Nagai Naoko、Mubasher Zainab、Parappurath Mahima、Ahmed Laiba、Ramos Raddy L、Kimata Koji、Azadi Parastoo、Cai Weikang、Zhao Jerry Yingtao
- Journal Title
  
  Glycobiology
  
  Volume: 34 Issue: 2
- DOI
  10.1093/glycob/cwad095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08588
[Journal Article] Versican A-subdomain is required for its adequate function in dermal development.2017
- Author(s)
  Hatano S, Nagai N, Sugiura N, Tsuchimoto J, Isogai z, Kimata K, Ota A, Karnan S, Hosokawa Y, Watanabe H
- Journal Title
  
  Connect Tissue Res
  
  Volume: 印刷中 Issue: 2 Pages: 178-190
- DOI
  10.1080/03008207.2017.1324432
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293096, KAKENHI-PROJECT-15K19561, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07352
[Journal Article] Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth.2016
- Author(s)
  Fanhchaksai K, Okada F, Nagai N, Pothacharoen P, Kongtawelert P, Hatano S, Makino S, Nakamura T, Watanabe H
- Journal Title
  
  Int J Cancer
  
  Volume: 138 Pages: 630-641
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293096
[Journal Article] Involvement of heparan sulfate 6-O-sulfation in regulation of energy metabolism and alteration of thyroid hormone levels in male mice.2013
- Author(s)
  Nagai N, Habuchi H, Sugaya N, Nakamura M, Imamura T, Watanabe H, Kimata K.
- Journal Title
  
  Glycobiology
  
  Volume: 23 Issue: 8 Pages: 980-992
- DOI
  10.1093/glycob/cwt037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590296, KAKENHI-PROJECT-23570148, KAKENHI-PROJECT-23570175, KAKENHI-PROJECT-23659556, KAKENHI-PROJECT-25293096
[Journal Article] Heparan sulfate 6-O-sulfotransferase isoform-d ependent regulatory effects of heparin on the activities of various proteases in mast cells a nd the biosynthesis of 6-O-sulfated heparin.2013
- Author(s)
  Anower-E-Khuda MF, Habuchi H, Nagai N, Habuchi O, Yokochi T, Kimata K.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 6 Pages: 3705-3717
- DOI
  10.1074/jbc.m112.416651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590296, KAKENHI-PROJECT-23570148, KAKENHI-PROJECT-23570175
[Journal Article] Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.2012
- Author(s)
  Ogawa H, Hatano S, Sugiura N, Nagai N, Sato T, Shimizu K, Narimatsu H, Kimata K, Watanabe H
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 8 Pages: 1-12
- DOI
  10.1371/journal.pone.0043806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390077, KAKENHI-PROJECT-23570148, KAKENHI-PROJECT-23570176, KAKENHI-PROJECT-23659556
[Journal Article] Cell surface heparin sulfate chains regulate local reception of FGF signaling in the mouse embryo2011
- Author(s)
  下川佳世
- Journal Title
  
  Developmental Cell
  
  Volume: 21 Issue: 2 Pages: 257-272
- DOI
  10.1016/j.devcel.2011.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370081, KAKENHI-PROJECT-22390077, KAKENHI-PROJECT-22590296, KAKENHI-PROJECT-23659556
[Journal Article] Suzuki M, Imamura, T Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho2011
- Author(s)
  Nakamura M, Uehara Y, Asada M, Honda E, Nagai,N, Kimata K
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Issue: 30 Pages: 26418-26423
- DOI
  10.1074/jbc.m111.251140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590296, KAKENHI-PROJECT-23570148
[Journal Article] Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.2011
- Author(s)
  Shimokawa K, Kimura-Yoshida C, Nagai N, Mukai K, Matsubara K, Watanabe H, Matsuda Y, Mochida K, Matsuo I
- Journal Title
  
  Developmental Cell
  
  Volume: 21 Pages: 257-2721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590296
[Journal Article] Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.2010
- Author(s)
  Ogawa H, Shionyu M, Sugiura N, Hatano S, Nagai N, Kubota Y, Nishiwaki K, Sato T, Gotoh M, Narimatsu H, Shimizu K, Kimata K, Watanabe H
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Issue: 44 Pages: 34155-34167
- DOI
  10.1074/jbc.m110.109553
- Data Source
  KAKENHI-PROJECT-22390077
[Journal Article] 6-O-Sulfation of heparan sulfate differentially regulates various fibroblast growth factor-dependent signalings in culture2008
- Author(s)
  Sugaya N, Habuchi H, Nagai N, Ashikari-Hada S, *Kimata K
- Journal Title
  
  Journal of Biological Chemistry 283(16)
  
  Pages: 10366-10376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770119
[Journal Article] ヘパラン硫酸による高分子リガンドの細胞内取り込み機構2008
- Author(s)
  永井尚子、木全弘治
- Journal Title
  
  蛋白質核酸酵素 9月号増刊
  
  Pages: 1564-1569
- Data Source
  KAKENHI-PROJECT-18770119
[Journal Article] Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality2007
- Author(s)
  Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, *Kimata K
- Journal Title
  
  Journal of Biological Chemistry 282(21)
  
  Pages: 15578-15588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770119
[Journal Article] Regulation of heparan sulfate 6-0-sulfation by beta-secretase activity2007
- Author(s)
  Nagai N, Habuchi H, Kitazume S, Toyoda H, Hashimoto Y, *Kimata K
- Journal Title
  
  Journal of Biological Chemistry 282(20)
  
  Pages: 14942-14951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770119
[Journal Article] Regulation of Heparan Sulfate 6-O-Sulfation by β-Secretase Activity2007
- Author(s)
  Naoko Nagai
- Journal Title
  
  Journal of Biological Chemistry 282(20)
  
  Pages: 14942-14951
- Data Source
  KAKENHI-PROJECT-18770119
[Journal Article] Regulation of heparan sulfate 6-O-sulfation by beta-secretase activity2007
- Author(s)
  Nagai N
- Journal Title
  
  J. Biol. Chem. 282巻・20号
  
  Pages: 14942-14951
- Data Source
  KAKENHI-PROJECT-14082206
[Journal Article] Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity.2004
- Author(s)
  N.Nagai, H.Habuchi, et al.
- Journal Title
  
  J Cell Sci 117
  
  Pages: 3331-3341
- Data Source
  KAKENHI-PROJECT-14082206
[Journal Article] Involvement of heparan sulfate6-O-sulfation in regulation of energy metabolism and alteration of thyroid hormone levels in male mice
- Author(s)
  Nagai N, Habuchi H, Sugaya N, NakamuraM, Imamura T, Watanabe H, Kimata K
- Journal Title
  
  Glycobiology
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22390077
[Presentation] 中枢性エネルギー代謝調節におけるへパラン硫酸の役割2023
- Author(s)
  永井尚子
- Organizer
  第４６回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08588
[Presentation] 細胞外マトリックスプロテオグリカンによる腫瘍微小環境の形成と腫瘍制御2015
- Author(s)
  ファンチャクサイ・カンダ，岡田　太，永井尚子、コンタウェラート・プラチャ、幡野その子、渡辺秀人
- Organizer
  第47回日本結合組織学会学術大会
- Place of Presentation
  東京
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25293096
[Presentation] Chondroitin Sulfate synthase-2/chondroitin polymerizing factor2012
- Author(s)
  Hideto Watanabe, Hiroyasu Ogawa, Masafumi Shionyu, Nobui Sugiura, Sonoko Hatano, Naoko Nagai, Takashi Sato Hisashi Narimatsu, Katsuji Shimizu, Koji Kimata
- Organizer
  characterization and impact on chondroitin sulfate biosynthesis 2012 Joint Meeting of the Society for Glycobiology & American Society for
- Place of Presentation
  San Diego,U.S.A.
- Data Source
  KAKENHI-PROJECT-22390077
[Presentation] Increased body weight in heparan sulfate6-O-sulfotransferase (Hs6st2) knockout mice2011
- Author(s)
  永井尚子
- Organizer
  第71回岡崎コンファレンス
- Place of Presentation
  岡崎コンファレンスセンター(愛知)
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-22590296
[Presentation] Chondroitin sulfate synthase-2/chondroitin polymerizing factor: characterization and impact on chondroitin sulfate biosynthesis2011
- Author(s)
  Hiroyasu Ogawa, Masashi Shionyu, Nobuo Sugiura, Sonoko Hatano, Naoko Nagai, Takashi Sato, Masanori Gotoh, Hisashi Narimatsu, Katsuji Shimizu, Koji Kimata, Hideto Watanabe
- Organizer
  7th International Conference onProteoglycans
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-22390077
[Presentation] Increased body weight in heparan sulfate 6-O-sulfotransferase (Hs6st2) knockout mice2011
- Author(s)
  永井尚子
- Organizer
  第71回岡崎コンファレンス
- Place of Presentation
  岡崎コンファレンスセンター
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-22590296
[Presentation] Altered Energy Expenditure in Heparan Sulfate 6-O-sulfotransferase-2 knockout mice2010
- Author(s)
  永井尚子
- Organizer
  第28回内藤コンファレンス
- Place of Presentation
  湘南国際村センター(神奈川県)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-22590296
[Presentation] Altered Energy Expenditure in Heparan Sulfate6-O-sulfotransferase-2 knockout mice2010
- Author(s)
  永井尚子
- Organizer
  第28回内藤コンファレンス
- Place of Presentation
  湘南国際村センター(神奈川県)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-22590296
[Presentation] Regulation of heparan sulfate 6-O-sulfation by β-secretase activity2008
- Author(s)
  Naoko Nagai
- Organizer
  Gordon Research Conference
- Place of Presentation
  Procter Academy
- Year and Date
  2008-07-06
- Data Source
  KAKENHI-PROJECT-18770119
[Presentation] Regulation of heparan sulfate 6-0-sulfation by b-secretase activity2008
- Author(s)
  Nagai N
- Organizer
  Gordon Research Conference
- Place of Presentation
  Procter academy, NH, USA
- Year and Date
  2008-07-06
- Data Source
  KAKENHI-PROJECT-18770119
[Presentation] ヘパラン硫酸6-O-硫酸基転移酵素3(HS6ST3)に結合する細胞内因子の探索2007
- Author(s)
  永井尚子
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18770119
[Presentation] ヘパラン硫酸6-0-硫酸基転移酵素HS6ST3の細胞内局在調節機構2007
- Author(s)
  永井尚子
- Organizer
  第5回糖鎖科学コンソーシアムシンポジウム
- Place of Presentation
  品川
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-18770119

1. WATANABE Hideto (90240514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. SUGIURA Nobuo (90454420)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. KIMATA Koji (10022641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. HABUCHI Osami (90024067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. HABUCHI Hiroko (90329821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. TSUCHIMOTO Jun (70632868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 幡野その子 (40434625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

NAGAI Naoko 永井 尚子

永井 尚子 ナガイ ナオコ

Research Projects

Research Products

Co-Researchers

脳へのレプチン送達制御におけるへパラン硫酸機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the control mechanism of leptin signal transduction by hypothalamic heparan sulfatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of proteoglycans in diseases: Regulation of cell behavior and maintenance of tissue structure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of chondroitin sulfate proteoglycan in maintenance of tissue structure and its remodeling under pathological conditions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism involved in energy metabolic regulation by heparan sulfatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the role of heparan sulfate 6O-sulfotransferase to the progression of Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spatio-temporal regulation of morphogenesis by heparan sulfate chains

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 生物機能モデルと新しいリソース・リサーチツール2011

Author(s)

Publisher

Data Source

[Book] 生物機能モデルと新しいリソース・リサーチツール2011

Author(s)

Publisher

Data Source

[Journal Article] Knockout of the intellectual disability-linked gene <i>Hs6st2</i> in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Versican A-subdomain is required for its adequate function in dermal development.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth.2016

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of heparan sulfate 6-O-sulfation in regulation of energy metabolism and alteration of thyroid hormone levels in male mice.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heparan sulfate 6-O-sulfotransferase isoform-d ependent regulatory effects of heparin on the activities of various proteases in mast cells a nd the biosynthesis of 6-O-sulfated heparin.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.2012

NAGAI Naoko 永井尚子

永井尚子ナガイナオコ