KONOHA Keiko 木葉敬子

Researcher Number	00369175
Affiliation (based on the past Project Information) *help	2010: 九州保健福祉大学, 薬学部, 助手 2009: 鈴鹿医療科学大学, 薬学部, 助手 2003 – 2008: 九州保健福祉大学, 薬学部, 助手
Review Section/Research Field	Except Principal Investigator Drug development chemistry / 医薬分子機能学 / Chemical biology / Environmental pharmacy
Keywords	Except Principal Investigator プロテオーム / アミロイド / 光反応 / 銅 / チャネル / プリオン病 / アルツハイマー病 / アポトーシス / カルシウム / 亜鉛 … More / peptide polymerization / screening / panning / proteome / amyloid / antibody-displayed phage / diazirine / photoreaction / ペプチド多量化 / スクリーニング / パニング / 抗体提示ファージ / ジアジリン / membrane lipid / cell culture / apoptosis / zinc / copper / Alzheimer's disease / prion disease / calcium homeostasis / 神経ステロイド / イオンチャネル / 微量元素 / カルシウムホメオスタシス / 細胞死 / 高次構造 / カルシウムホメオスタシ / パーキンソン / プリ / アルツハイマー / アルミニウム / 培養神経細胞 / 神経細胞死 / シヌクレイン / プリオン蛋白 / βアミロイド蛋白 / 細胞培養 / 膜脂質 / ペプチド / バイオテクノロジー / 分析化学 / 薬学 / 糖鎖 / 神経科学 / カルノシン / イメージング / RT-PCR / 小胞体 / プリオン / 虚血性神経細胞死 / 小胞体ストレス / p8 / 無機金属毒性 / 中毒学 Less

Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Kyushu University of Health and Welfare
Involvement of calcium homeostasis in the apoptotic neuronal death induced by zinc
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University of Health and Welfare
Development of screening system for antibody-displayed phages by photo panning method : isolation of anti-amyloid antibody
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyushu University of Health and Welfare
Formation of ion chyannels by amyloidogenic proteins and screening for protective substances
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
  Tokyo Metropolitan Organization for Medical Research

All 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Patent

[Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC.2010
- Author(s)
  Y.Sadakane, K.Konoha, M.Kawahara, K.Nakagomi
- Journal Title
  
  Chem.& Biodivers. 7
  
  Pages: 1371-1379
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2009
- Author(s)
  Y.Sadakane, I.Otsuka, K.Konoha, H.Koyama, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 31
  
  Pages: 9-10
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death2008
- Author(s)
  Sadakane Y, Konoha K, Nagata T, Kawahara M
- Journal Title
  
  Trace Nutrient Res 25
  
  Pages: 59-63
- NAID
  40016413893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death.2008
- Author(s)
  Y.Sadakane, K.Konoha, T.Nagata, M.Kawahara
- Journal Title
  
  Trace Nutrients Res. 25
  
  Pages: 41-45
- NAID
  40016413893
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death.2008
- Author(s)
  Sadakane Y, Konoha K, Nagata T, Kawahara M
- Journal Title
  
  Trace Nutrient Res 25
  
  Pages: 59-63
- NAID
  40016413893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia : camosine a target for drug of vascular type of dementia.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Journal Title
  
  Recent Patents on CNS Drug Discovery, (with peer review.) 2
  
  Pages: 145-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of zinc: the involvement of calcium homeostasis and carnosine2007
- Author(s)
  Kawahara M., Konoha K., Sadakane Y.
- Journal Title
  
  Biomed. Res. Trace Elements 18
  
  Pages: 26-34
- NAID
  10018910865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Aluminum and human health:its intake,bioavailability and neurotoxicity2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y.
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 111-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of zinc:the involvement of calcium homeostasis and carnosine2007
- Author(s)
  M.Kawahara, K.Konoha, Y.Sadakane
- Journal Title
  
  Biomed Res Trace Elements 18
  
  Pages: 26-34
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica) against zinc-induced neuronal cell death : Carnosine and an unknown substance.2007
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M. Kawahara
- Journal Title
  
  Trace Nutrient Res.(with peer review.) 24
  
  Pages: 1-4
- NAID
  40015808263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of zinc : the involvement of calcium homeostasis and camosine.2007
- Author(s)
  M. Kawahara, K. Konoha, Y. Sadakane
- Journal Title
  
  Biomed. Res. Trace Elements, (with peer review.) 18
  
  Pages: 26-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Aluminum and human health:its intake,bioavailability and neurotoxicity2007
- Author(s)
  M.Kawahara, K.Konoha, T.Nagata, Y.Sadakane
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 111-120
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia: carnosine a target for drug of vascular type of dementia2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y.
- Journal Title
  
  Recent Patents on CNS Drug Discovery 2
  
  Pages: 145-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica)against zinc-induced neuronal cell death:Carnosine and an unknown substance2007
- Author(s)
  Y.Sadakane, K.Konoha, T.Nagata, M.Kawahara
- Journal Title
  
  Trace Nutrient Res. 24
  
  Pages: 1-4
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia:carnosine a target for drug of vascular type of dementia2007
- Author(s)
  M.Kawahara, K.Konoha, T.Nagata, Y.Sadakane
- Journal Title
  
  Recent Patents on CNS Drug Discovery 2
  
  Pages: 145-149
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica)against zinc-induced neuronal cell death:Carnosine and an unknown substance2007
- Author(s)
  Sadakane Y., Konoha K., Nagata T., Kawahara M
- Journal Title
  
  Trace Nutrient Res 24
  
  Pages: 98-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective activity of the extracts from Japanese eel (Anguilla japonica) against zinc-induced neuronal cell death: Carnosine and an unknown substance.2007
- Author(s)
  Sadakane Y., Konoha K., Nagata T., Kawahara M
- Journal Title
  
  Trace Nutrient Res. 24
  
  Pages: 98-105
- NAID
  40015808263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  Konoha K, Nagata T, Sadakane Y, Kawahara M
- Journal Title
  
  Biomed. Res. Trace Elements 18
  
  Pages: 395-399
- NAID
  10021097781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica)against zinc-induced neuronal cell death:Carnosine and an unknown substance2007
- Author(s)
  Sadakane Y., Konoha K., Nagata T., Kawahara M
- Journal Title
  
  Trace Nutrient Res. 24
  
  Pages: 111-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  Konoha K, Nagata T, Sadakane Y, Kawahara M
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 393-397
- NAID
  10021097781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of zinc:the involvement of calcium homeostasis and carnosine2007
- Author(s)
  Kawahara M., Konoha K., Sadakane Y.
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 26-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Aluminum and human health: its intake, bioavailability and neurotoxicity2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y.
- Journal Title
  
  Biomed. Res. Trace Elements 18
  
  Pages: 111-120
- NAID
  130004456835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  K.Konoha, T.Nagata, Y.Sadakane, M.Kawahara
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 393-397
- NAID
  10021097781
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex2007
- Author(s)
  Konoha K, Nagata T, Sadakane Y, Kawahara M
- Journal Title
  
  Biomed.Res.Trace Elements 18
  
  Pages: 395-399
- NAID
  10021097781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Aluminum and human health : its intake, bioavailability and neurotoxicity.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Journal Title
  
  Biomed. Res. Trace Elements, (with peer review.) 18
  
  Pages: 111-120
- NAID
  130004456835
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Protective substances against zinc-induced neuronal death after ischemia:carnosine a target for drug of vascular type of dementia2007
- Author(s)
  Kawahara M., Konoha K., Nagata T., Sadakane Y
- Journal Title
  
  Recent Patents on CNS Drsicovery 2
  
  Pages: 145-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590133
[Journal Article] Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex.2007
- Author(s)
  K. Konoha, T. Nagata, Y. Sadakane, M. Kawahara
- Journal Title
  
  Biomed. Res. Trace Elements, (with peer review.) 18
  
  Pages: 393-397
- NAID
  10021097781
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Photoaffinity labeling of opioid-binding cell-adhesion molecule(OBCAM) by phenyldiazirine-integrated ligand.2006
- Author(s)
  Y.sadakane, E.Kitamoto, T.Tomohiro, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  J.KUHW 8
  
  Pages: 179-185
- NAID
  110006407510
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease.2006
- Author(s)
  Y. Sadakane, S. Kumamoto, K. Konoha, M. Kawahara, K. Nakagomi
- Journal Title
  
  Peptide Sciences.(with peer review.) 43
  
  Pages: 284-284
- NAID
  10020529985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Photoaffinity labeling of opioid-binding cell-adhesion molecule (OBCAM) by phenyldiazirine-integrated ligand2006
- Author(s)
  Y.sadakane, E.Kitamoto, T.Tomohiro, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  J.KUHW 8
  
  Pages: 179-185
- NAID
  110006407510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases,2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  J.Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Hatanaka : Phenyldiazirine unit for converting peptides, proteins, DNAs, and sugars to photoaffinity ligands2006
- Author(s)
  Y. Sadakane, M. Kaneda, H. Nakashima, T. Tomohiro, K. Konoha, M. Kawahara, Y. Hatanaka
- Journal Title
  
  Photomedicine and Photobiology(without peer review.) 28
  
  Pages: 11-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptidesincluding Alzheimer's beta-amyloid protein, prion protein fragment peptide, and aipha-synuclein fragment.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Journal Title
  
  Alzheimer r Disease : New Advances(with peer review.)
  
  Pages: 323-327
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Phenyldiazirine unit for converting peptides,proteins,DNAs,and sugars to photoaffinity ligands2006
- Author(s)
  Y.sadakane, M.Kaneda, H.Nakashima, T.Tomohiro, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 28
  
  Pages: 11-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Carnosine protects GT1-7 cell against zinc-induced neurotoxicity:a possible candidate for treatment for vascular type of dementia2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Trace Nutrients Research 23
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Journal Title
  
  J. Health Sd.(with peer review.) 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease2006
- Author(s)
  Y.Sadakane, S.Kumamoto, K.Konoha, M.Kawahara, K.Nakagomi
- Journal Title
  
  Peptide Sciences 43
  
  Pages: 284-284
- NAID
  10020529985
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  J.Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  J. Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Carnosine protects GT 1-7 cell against zinc-induced neurotoxicity : a possible candidate for treatment for vascular type of dementia.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Journal Title
  
  Trace Nutrients Research, (with peer review.) 23
  
  Pages: 1-8
- NAID
  40015330447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Carnosine protects GT1-7 cell against zinc-induced neurotoxicity : a possible candidate for treatment for vascular type of dementia.2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Trace Nutrients Research 23
  
  Pages: 1-8
- NAID
  40015330447
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptides including Alzheimer's beta-amyloid protein,prion protein fragment peptide, and alpha-synuclein fragment2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  Alzheimer's Disease:New Advances
  
  Pages: 323-327
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Zinc neurotoxicity and its role in neurodegenerative diseases2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Journal Title
  
  J.Health Sci. 52
  
  Pages: 1-8
- NAID
  110006163207
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Photoaffinity identification of DNA-binding proteins : Comparison of labeling efficiency between photoreactive DNAs bearing diazirine or benzophenone.2005
- Author(s)
  Y.Sadakane, T.Takagi, T.Tomohiro, K.Tsurusawa, K.Konoha, M.Kawahara, Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 26
  
  Pages: 35-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Preparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane, T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J.Kyushu Univ.Health Welfare 6
  
  Pages: 287-298
- NAID
  110004633177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Preparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane, T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J. Kyushu Univ. Health Welfare 6
  
  Pages: 287-298
- NAID
  110004633177
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Y. Hatanaka : Photoaffinity labeling of opioid-binding cell-adhesion molecule(OBCAM) by phenyldiazirine-integrated ligand.2005
- Author(s)
  Y. Sadakane, E. Kitamoto, T. Tomohiro, K. Konoha, M. Kawahara, Y. Hatanaka
- Journal Title
  
  J. KUHW(without peer review.) 8
  
  Pages: 179-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Journal Article] Photoaffinity identification of DNA-binding proteins : Comparison of labeling efficiency between photoreactive DNAs bearing diazirine or benzophenone.2005
- Author(s)
  Y.Sadakane, T.Takagi, T.Tomohiro, K.Tsurusawa, K.Konoha, M.Kawahara.Y.Hatanaka
- Journal Title
  
  Photomedicine and Photobiology 26
  
  Pages: 35-40
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Peparation of recombinant lysosomal cysteine proteases highly expressed in mouse placenta, cathepsin-P/J and -6.2005
- Author(s)
  Y.Sadakane T.Ito, T.Tomohiro, K.Konoha, M.Kawahara, S.Imanishi, Y.Hatanaka, K.Nakagomi
- Journal Title
  
  J.Kyushu Univ.Health Welfare 6
  
  Pages: 287-298
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Protective activity of mango (Mangifera indica L.) fruit against a zinc-induced neuronal cell death is independent of its antioxidant activity2005
- Author(s)
  Sadakane Y., Konoha K., Kawahara M.
- Journal Title
  
  Trace Nutrients Res. 22
  
  Pages: 73-79
- NAID
  40015392247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Neurotoxicity of aluminum on primary cultured neurons of rat cerebral cortex2004
- Author(s)
  Konoha K., Kawahara M.
- Journal Title
  
  Proceedings of the 6^<th> International symposium on plant-soil interactions at low pH
  
  Pages: 102-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] 亜鉛ホメオスタシスの異常と神経細胞死2004
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Journal Title
  
  Trace Nutrients Research 21
  
  Pages: 77-83
- NAID
  40007140673
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc2004
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  Biomed. Res. Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] 亜鉛によって引き起こされる培養神経細胞アポトーシスのメカニズムの検討2004
- Author(s)
  木葉敬子, 河原正博
- Journal Title
  
  九州保健福祉大学研究紀要 5
  
  Pages: 247-251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc2004
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  Biomed.Res.Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc2004
- Author(s)
  Konoha K., Sadakane Y., Kawahara M.
- Journal Title
  
  Biomed.Res. Trace Elements 15
  
  Pages: 275-277
- NAID
  10027573511
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Implications of calcium homeostasis and neurotrophic factors in neurotoxicity of aluminum on primary cultured neurons2004
- Author(s)
  Konoha K., Sadakane Y., Imamura L., Tsuda M., Kawahara M.
- Journal Title
  
  Yakugakuzassi 124,Suppl.a
  
  Pages: 63-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Aluminum maltolate inhibits brain-derived neurotrophic factor induced intracellular free calcium elevations in cultured rat hippocampal neurons2003
- Author(s)
  Konoha K., Imamura L., Tsuda M., Kawahara M.
- Journal Title
  
  Biomed.Res.Trace Elements 14
  
  Pages: 173-187
- NAID
  10027904297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Journal Article] Aluminum maltolate inhibits brain-derived neurotrophic factor induced intracellular free calcium elevations in cultured rat hippocampal neurons2003
- Author(s)
  Konoha K., Imamura L., Tsuda M., Kawahara M.
- Journal Title
  
  Biomed. Res. Trace Elements 14
  
  Pages: 173-175
- NAID
  10027904297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Patent] 脳血管性認知症の治療剤および該治療剤を含有する飲食物、補助食品2008
- Inventor(s)
  川原正博, 定金豊, 木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Industrial Property Number
  2008-098675
- Filing Date
  2008-04-04
- Data Source
  KAKENHI-PROJECT-19590133
[Patent] 「脳血管性認知症の治療剤および該治療剤を含有する飲食物、補助食品」2008
- Inventor(s)
  川原正博、定金豊、木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Industrial Property Number
  2008-098675
- Filing Date
  2008-04-04
- Data Source
  KAKENHI-PROJECT-19590133
[Patent] 「脳血管性認知症の予防または治療用飲食物、その包装または容器ならびに脳血管性認知症の予防または治療薬」2007
- Inventor(s)
  川原正博、定金豊、木葉敬子
- Industrial Property Rights Holder
  九州保健福祉大学
- Patent Publication Number
  2007-314467
- Acquisition Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19590133
[Patent] 「脳血管性認知症の予防または治療用飲食物」2006
- Inventor(s)
  河原正博, 木葉敬子, 定金豊
- Industrial Property Rights Holder
  河原正博, 木葉敬子, 定金豊
- Industrial Property Number
  2006-145857
- Filing Date
  2006-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572106
[Presentation] Analysis of Alternation of A-Asp and L-Asn residures in peptides related to conformational disease.2009
- Author(s)
  Y.Sadakane, K.Konoha, M.Kawahara, K.Nakagomi
- Organizer
  International D-amino acid Research (IDAR2009)
- Place of Presentation
  Awazi Inland, Japan
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン蛋白断片ペプチドPrP106-126のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功, 永田哲也, 木葉敬子, 定金豊, 川原正博, 横山祥子
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] HPLCによるラット脳内カルノシンの定量2009
- Author(s)
  木葉敬子, 定金豊, 永田哲也, 川原正博
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白断片ペプチドPrP106-126 のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功,永田哲也,木葉敬子,定金豊,川原正博,横山祥子
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 糖鎖結合タンパク質に適した光化学的スクリーニング法の開発2009
- Author(s)
  定金豊,木葉敬子,川原正博,畑中保丸
- Organizer
  第26回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博,永田哲也,大塚功,木葉敬子,定金豊,横山祥子
- Organizer
  日本薬学会シンポジウム「金属の関与する生命科学(II)トキシコメタロミクス研究の新展開～最新分析法開発から創薬、診断、治療へのアプローチ」
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 中枢神経保護作用を目的としたL-carnosine 誘導体の合成2009
- Author(s)
  宮越辰則,鳥ヤ尾篤,渡邉暁子,坂本正徳,木葉敬子,定金豊,川原正博,山崎哲郎
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] アルツハイマーβアミロイドペプチドの自己構造変化を認識する抗体作製と応用2009
- Author(s)
  定金豊,木葉敬子
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博, 永田哲也, 大塚功, 木葉敬子, 定金豊, 横山祥子
- Organizer
  日本薬学会シンポジウム「金属の関与する生命科学(II) トキシコメタロミクス研究の新展開~最新分析法開発から創薬、診断、治療へのアプローチ」
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Carnosine inhibits β-sheet formation of PrP106-126 and protects against its neurotoxicity.2009
- Author(s)
  Kawahara M, Nagata T, Konoha K, Sadakane Y
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2009
- Place of Presentation
  Wien, Austria
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 環状L-carnosine誘導体の合成とその生物学的評価2009
- Author(s)
  鳥や尾篤, 宮越辰則, 渡邉暁子, 坂本正徳, 木葉敬子, 定金豊, 川原正博, 山崎哲郎
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] HPLCによるラット脳内カルノシンの定量2009
- Author(s)
  木葉敬子, 他
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] HPLC によるラット脳内カルノシンの定量2009
- Author(s)
  木葉敬子,定金豊,永田哲也,川原正博
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白断片ペプチドPrP106-126のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功,永田哲也,木葉敬子,定金豊,川原正博,横山祥子
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 中枢神経保護作用を目的としたL-carnosine誘導体の合成2009
- Author(s)
  宮越辰則, 鳥ヤ尾篤, 渡邉暁子, 坂本正徳, 木葉敬子, 定金豊, 川原正博, 山崎哲郎
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 光反応性生体高分子リガンドの開発と光化学的スクリーニング法への応用2009
- Author(s)
  定金豊,大塚功,木葉敬子,畑中保丸
- Organizer
  第31回日本光医学・光生物学会
- Place of Presentation
  大阪
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 環状 L-carnosine 誘導体の合成とその生物学的評価2009
- Author(s)
  鳥や尾篤,宮越辰則,渡邉暁子,坂本正徳,木葉敬子,定金豊,川原正博,山崎哲郎
- Organizer
  日本薬学会第129 回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博, 永田哲也, 大塚功, 木葉敬子, 定金豊, 横山祥
- Organizer
  日本薬学会第129回年会シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] ジアジリンを利用した光化学的スクリーニング法の開発2008
- Author(s)
  定金豊、木葉敬子、畑中保丸
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Inhibitory mechanism of metal ionsonzinc-induced neurotoxicity of culturedneuronal cells.2008
- Author(s)
  K. Konoha, Y. Sadakane, T. Nagata, M. Kawahara
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛による培養神経細胞死に対する金属イオンの阻害メカニズムの検討2008
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 魚介類水抽出液からの脳血管認知症予防物質の単離と同定2008
- Author(s)
  定金豊、木葉敬子、永田哲也、川原正博
- Organizer
  日本微量栄養素学会第25 回学術集会
- Place of Presentation
  京都
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン断片蛋白PrP106-126のコンフォーメーシヨンの違いによるGM1への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功, 永田哲也, 木葉敬子, 定金豊, 川原正博, 横山祥子
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  宮崎(延岡)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する亜鉛および銅の影響2008
- Author(s)
  永田哲也, 木葉敬子, 定金豊, 川原正博
- Organizer
  第19回日本微量元素学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M. KAWAHARA, T. NAGATAl, OHTSUKA, K. KONOHA, Y. SADAKANE, S. YOKOYAMA
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D. C., U. S. A
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 魚介類水抽出液からの脳血管認知症予防物質の単離と同定2008
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  日本微量栄養素学会第25回学術集会
- Place of Presentation
  京都
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] L-Carnosine誘導体の合成と生理作用について2008
- Author(s)
  宮越辰則、鳥や尾篤、渡邉暁子、坂本正徳、木葉敬子、定金豊、川原正博、山崎哲郎
- Organizer
  第25 回日本薬学会九州支部大会
- Place of Presentation
  延岡
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による神経細胞死を抑制する成分:魚介類バイオマスからの単離と同定2008
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  第21 回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による神経細胞死:クエン酸の抑制活性とそのメカニズムについて2008
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛による培養神経細胞死に対する金属イオンの阻害メカニズムの検討2008
- Author(s)
  木葉敬子, 永田哲也, 定金豊, 川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] マウス神経株化細胞を用いた亜鉛による神経細胞死メカニズムの解明2008
- Author(s)
  定金豊、木葉敬子、永田哲也、川原正博
- Organizer
  第18 回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による神経細胞死:クエン酸の抑制活性とそのメカニズムについて2008
- Author(s)
  定金豊,木葉敬子,永田哲也、川原正博
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する毒性メカニズムの検討2008
- Author(s)
  永田哲也、定金豊,木葉敬子、川原正博
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する毒性メカニズムの検討2008
- Author(s)
  永田哲也、木葉敬子、定金豊、川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による培養神経細胞死に対する金属イオンの阻害メカニズムの検討2008
- Author(s)
  木葉敬子,永田哲也、定金豊,川原正博
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Zinc-induced neuronal cell death : inhibitory activity of citric acid and its Zinc-inducedmechanism.2008
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M.Kawahara
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 光化学的スクリーニング法の開発2008
- Author(s)
  定金豊、木葉敬子、畑中保丸
- Organizer
  第30回日本光医学・光生物学会
- Place of Presentation
  島根
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン蛋白による培養神経細胞に対する亜鉛および銅の影響2008
- Author(s)
  永田哲也、木葉敬子、定金豊、川原正博
- Organizer
  第19 回日本微量元素学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン断片蛋白PrP106-126のコンフォーメーションの違いによるGM1への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功、永田哲也、木葉敬子、定金豊、川原正博、横山祥子
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  (延岡)
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] L-Carnosine誘導体の合成と生理作用について2008
- Author(s)
  宮越辰則, 鳥や尾篤, 渡邉暁子, 坂本正徳, 木葉敬子, 定金豊, 川原正博, 山崎哲郎
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  宮崎(延岡)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン断片蛋白PrP106-126 のコンフォーメーションの違いによるGM1 への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功、永田哲也、木葉敬子、定金豊、川原正博、横山祥子
- Organizer
  第25 回日本薬学会九州支部大会
- Place of Presentation
  延岡
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] YOKOYAMA Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M.KAWAHARA, T.NAGATA1, OHTSUKA, K.KONOHA, Y.SADAKANE, S
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 亜鉛による神経細胞死を抑制する成分 : 魚介類バイオマスからの単離と同定2008
- Author(s)
  木葉敬子, 定金豊, 永田哲也, 川原正博
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] GTl-7マウス神経株化細胞を用いた亜鉛による神経細胞死メカニズムの解明2008
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] プリオン蛋白による培養神経細胞に対する毒性メカニズムの検討2008
- Author(s)
  永田哲也, 定金豊, 木葉敬子, 川原正博
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Molecular mechanism of neurotoxicity induced by prion protein peptide.2008
- Author(s)
  T. Nagata, Y.Sadakane, K. Konoha, M.Kawahara
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M. KAWAHARA, T. NAGATA, OHTSUKA, K. KONOHA, Y. SADAKANE, S. YOKOYAMA
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による培養神経細胞死メカニズムの検討2007
- Author(s)
  木葉敬子、永田哲也、定金豊、川原正博
- Organizer
  第17 回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 農産物・魚介類中における脳血管性認知症予防物質の探索と単離・構造解析2007
- Author(s)
  川原正博,木葉敬子,永田哲也,定金豊
- Organizer
  第24 回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Purification and structural determination of the suppression substance for cerebrovascular dementia in farm products and seafoods.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  24th Symposium of Trace Nutrients Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango(Mangifera indica L.)fruit:a candidate for treatment of neurodegeneration after ischemia2007
- Author(s)
  M.Kawahara, K.Konoha, T.Nagata, Y.Sadakane
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analysis of alternation of L-Asp residues in recombinant human alpha-crystallin by reversed-phase HPLC.2007
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M. Kawahara, K. Nakagomi, N. Fujii
- Organizer
  3rd D-amino acid research meeting
- Place of Presentation
  Tokushima, Japan
- Year and Date
  2007-09-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] L-β-アスパラギン酸含有ペプチドの逆相HPLC定量法によるアスパラギン酸残基の異性化速度の解析:タンパク質の高次構造との関係2007
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博, 中込和哉, 藤井紀子
- Organizer
  第3回D-アミノ酸研究会
- Place of Presentation
  徳島
- Year and Date
  2007-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] マンゴー(Mangifera indica L.)果実抽出液の神経細胞死抑制活性成分の同定2007
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] アルミニウムのラット大脳皮質培養神経細胞に対する毒性の化学形態による比較2007
- Author(s)
  木葉敬子, 永田哲也, 定金豊, 川原正博
- Organizer
  第18回日本微量元素学会
- Place of Presentation
  福井
- Year and Date
  2007-07-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] クエン酸による神経細胞死抑制活性とその作用機構の解明2007
- Author(s)
  定金豊,木葉敬子,永田哲也、川原正博
- Organizer
  第24 回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango(Mangifera indica L.) fruit : a candidate for treatment of neurodegeneration after ischemia.2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Mechanism for zinc-induced neuronal cell death.2007
- Author(s)
  K. Konoha, T. Nagata, Y. Sadakane, M. Kawahara
- Organizer
  17th Symposium on Role of Metals in Biological Reactions, Biology and Medicine
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 農産物・魚介類中における脳血管性認知症予防物質の探索と単離・構造解析2007
- Author(s)
  川原正博, 木葉敬子, 永田哲也, 定金豊
- Organizer
  第24回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Characterization of inhibitory compounds in Mangifera indica L.fruit extract, which suppress the zinc-induced neurotoxicity of immortalized hypothalamic neurons.2007
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of apan
- Place of Presentation
  Toyama, Japan
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] クエン酸による神経細胞死抑制活性とその作用機構の解明2007
- Author(s)
  定金豊, 木葉敬子, 永田哲也, 川原正博
- Organizer
  第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] アルミニウムのラット大脳皮質培養神経細胞に対する毒性の化学形態による比較2007
- Author(s)
  木葉敬子、定金豊、川原正博
- Organizer
  第18 回日本微量元素学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] アルミニウムのラット大脳皮質培養神経細胞に対する毒性の化学形態による比較2007
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  第18回日本微量元素学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による培養神経細胞死メカニズムの検討2007
- Author(s)
  木葉敬子, 永田哲也, 定金豊, 川原正博
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango(Mangifera indica L.)fruit: a candidate for treatment of neurodegeneration after ischemia2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  Neuroscience 2007(Society for Neuroscience)
- Place of Presentation
  San Diego(U.S.A.)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] 亜鉛による培養神経細胞死メカニズムの検討2007
- Author(s)
  木葉敬子、定金豊、永田哲也、川原正博
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] カルノシンによる神経細胞死抑制活性とその作用機構の解明2007
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 農産物・魚介類中における脳血管性認知症予防物質の探索と単離,構造解析2007
- Author(s)
  川原正博, 木葉敬子, 永田哲也, 定金豊
- Organizer
  第24回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Inhibitory activity and mechanisms of carnosine against the zinc-induced neurotoxicity of immortalized hypothalamic neurons.2007
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of apan
- Place of Presentation
  Toyama, Japan
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Structural comparison of Aluminum-toxicity for rat primary culture cell of cerebral cortex.2007
- Author(s)
  K. Konoha, T. Nagata, Y. Sadakane, M. Kawahara
- Organizer
  18th Japan Society for Biomedical Research on Trace Elements
- Place of Presentation
  Fukui, Japan
- Year and Date
  2007-07-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Zinc-induced apoptosis of GT1-7 cells are protected by mango (Mangifera indica L.) fruit: a candidate for treatment of neurodegeneration after ischemia2007
- Author(s)
  M. Kawahara, K. Konoha, T. Nagata, Y. Sadakane
- Organizer
  Neuroscience 2007 (Society for Neuroscience)
- Place of Presentation
  San Diego (U.S.A.)
- Data Source
  KAKENHI-PROJECT-19590133
[Presentation] Investigation of the mechanism of zinc-induced neuronal cell death by using citrate.2007
- Author(s)
  Y. Sadakane, K. Konoha, T. Nagata, M. Kawahara
- Organizer
  24th Annual Meeting of Kyushu branch of the Pharmaceutical Society of Japan
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening with zinc-induced neuronal degradation for the substances for suppression of cerebrovascular dementia.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  23rd Annual Meeting of Kyushu branch of the Pharmaceutical Society of Japan
- Place of Presentation
  Kumamoto, Japan
- Year and Date
  2006-12-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening of the substances for suppression of cerebrovascular dementia and analysis for the peptide from seafood.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  19th Biomedical analytical Science Symposium
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 海産物由来ペプチドの分析と脳血管性認知症予防物質のスクリーニング2006
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Organizer
  第19回バイオメディカル分析科学シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] コンフォメーション病に関わるペプチドでのL-AspとL-Asn残基の構造変化分析手法2006
- Author(s)
  定金豊, 木葉敬子, 川原正博, 中込和哉
- Organizer
  第19回バイオメディカル分析科学シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptides including Alzheimer's beta-amyloid protein,prion protein fragment peptide,and alpha-synuclein fragment2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid,Spain
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening of suppression substance for cerebrovascular dementia : usefulness of mango fruit and eel.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  6th OUS Forum 2006
- Place of Presentation
  Okayama, Japan
- Year and Date
  2006-11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 脳血管性認知症の予防物質の探索:マンゴーとウナギの有用性2006
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  第6回OUSフオーラム2006
- Place of Presentation
  岡山
- Year and Date
  2006-11-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease.2006
- Author(s)
  Y. Sadakane, S. Kumamoto, K. Konoha, M. Kawahara, K. Nakagomi
- Organizer
  43JPS/PEM4
- Place of Presentation
  Yokohama, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Carnosine protects against zinc-induced apoptosis of GT1-7 cells and cultured rat hippocampal neurons:a candidate for the drugs for neurode generation after ischemia2006
- Author(s)
  K.Konoha, Y.Sadakane, M.Kawahara
- Organizer
  Neuroscience 2006
- Place of Presentation
  Atlanta,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] L-AspとL-Asn残基の構造変化分析手法の開発:コンフォメーション病に関わるペプチドの分析2006
- Author(s)
  定金豊, 木葉敬子, 川原正博, 中込和哉
- Organizer
  第2回D-アミノ酸研究会
- Place of Presentation
  京都
- Year and Date
  2006-09-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Development of analytical method for structure alternation of L-Asp and L-Asn : peptides concerned with conformation disease.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara, K. Nakagomi
- Organizer
  2nd D-amino acid research meeting
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-09-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛神経毒性を指標としたスクリーニングによる脳血管性認知症予防物質の探索2006
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  第23回日本薬学会九州支部大会
- Place of Presentation
  熊本
- Year and Date
  2006-12-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] 亜鉛神経毒性スクリーニングによる脳血管性認知症予防物質の探索2006
- Author(s)
  木葉敬子, 定金豊, 川原正博
- Organizer
  第23回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2006-06-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analytical method for structure alternation of L-Asp and L-Asn in the peptides concerned with conformation disease.2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara, K. Nakagomi
- Organizer
  19th Biomedical analytical Science Symposium
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Inhibition of neuronal apoptosis by mango fruits-utilization of immature fruit-2006
- Author(s)
  Y. Sadakane, K. Konoha, M. Kawahara
- Organizer
  5th Congress of innovation with Academia, Industry and Government
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] マンゴー果実抽出液が神経細胞の自殺をくいとめる〜未熟果実の利用法2006
- Author(s)
  定金豊, 木葉敬子, 川原正博
- Organizer
  第5回産学官連携推進会議
- Place of Presentation
  京都
- Year and Date
  2006-06-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Screening of the substances for suppression of cerebrovascular dementia using zinc-induced neuronal degradation.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  23rd Symposium of Trace Nutrients Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Pore formation and distuption of calciumhomeostasis by amyloidogenic peptides including Alzheimer's beta-amyloid protein, prion protein fragment peptide, and alpha-synuclein fragment.2006
- Author(s)
  K. Konoha, Y. Sadakane, M. Kawahara
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid, Spain
- Year and Date
  2006-07-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Analysis of Structural Alternations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Disease2006
- Author(s)
  Y.Sadakane, S.Kumamoto, K.Konoha, M.Kawahara, K.Nakagomi
- Organizer
  43JPS/PEM4
- Place of Presentation
  Yokohama,Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590114
[Presentation] Carnosine protects against zinc-induced apoptosis of GT1-7 cells and cultured rat hippocampal neurons : a candidate for the drugs for neurodegeneration after ischemia.2006
- Author(s)
  K. Konoha Y. Sadakane, M. Kawahara
- Organizer
  Neuroscience 2006
- Place of Presentation
  Atlanta, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590114

1. KAWAHARA Masahiro (40224828)

# of Collaborated Projects: 4 results

# of Collaborated Products: 145 results
2. SADAKANE Yutaka (60293304)

# of Collaborated Projects: 3 results

# of Collaborated Products: 132 results
3. OHTSUKA Isao (20389589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. NAGATA Tetusya (00454992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 41 results

KONOHA Keiko 木葉 敬子

Research Projects

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Co-Researchers

Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions

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Involvement of calcium homeostasis in the apoptotic neuronal death induced by zinc

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Development of screening system for antibody-displayed phages by photo panning method : isolation of anti-amyloid antibody

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Formation of ion chyannels by amyloidogenic proteins and screening for protective substances

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[Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC.2010

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[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2009

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[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death2008

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NAID

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[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death.2008

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NAID

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[Journal Article] Improvement of screening for protective substances against zinc-induced neuronal cell death.2008

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NAID

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[Journal Article] Protective substances against zinc-induced neuronal death after ischemia : camosine a target for drug of vascular type of dementia.2007

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[Journal Article] Neurotoxicity of zinc: the involvement of calcium homeostasis and carnosine2007

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NAID

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[Journal Article] Aluminum and human health:its intake,bioavailability and neurotoxicity2007

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[Journal Article] Neurotoxicity of zinc:the involvement of calcium homeostasis and carnosine2007

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[Journal Article] Protective activity of the extracts from Japanese eel(Anguilla japonica) against zinc-induced neuronal cell death : Carnosine and an unknown substance.2007

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NAID

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[Journal Article] Neurotoxicity of zinc : the involvement of calcium homeostasis and camosine.2007

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KONOHA Keiko 木葉敬子