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Igawa Ken  井川 健

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… Alternative Names

井川 健  イガワ ケン

IGAWA Ken  井川 健

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Researcher Number 00372441
Other IDs
Affiliation (Current) 2025: 獨協医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 獨協医科大学, 医学部, 教授
2017: 獨協医科大学, 医学部, 教授
2016: 東京医科歯科大学, 医歯学総合病院, 准教授
2015 – 2016: 東京医科歯科大学, 医学部附属病院, 准教授
2015: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 … More
2012 – 2014: 東京医科歯科大学, 医学部附属病院, 講師
2010: Osaka University, 医学系研究科, 講師
2009: Tokyo Medical and Dental University, 医学部附属病院, 講師
2006: 東京医科歯科大学, 大学院医歯薬学総合研究科, 助手
2004 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Dermatology / Basic Section 53050:Dermatology-related
Except Principal Investigator
Dermatology / Basic Section 53050:Dermatology-related
Keywords
Principal Investigator
アトピー性皮膚炎 / ゲノム編集 / ヒト / 角化細胞 / フィラグリン / 人工ヌクレアーゼ / iPS細胞 / アレルギー / 表皮角化細胞 / 病態解明 … More / MAIT細胞 / 病態形成機序 / マウスモデル / K14 / TALEN / 人工多能性幹細胞 / フィラグリン遺伝子 / ケラチン遺伝子 / ヒトiPS細胞 / TALENs / Cas9/CRISPR / 接触過敏反応 / RNA干渉 / 治療 / STAT6 / 好酸球 / IgE / ケモカイン … More
Except Principal Investigator
iPS細胞 / 血管型エーラス・ダンロス症候群 / ドミナントネガティブ効果 / COL3A1 / 3型コラーゲン / SNP / siRNA / エーラス・ダンロス症候群 / CD34 / 線維芽細胞 / ガドリニウムイオン / 腎性全身性線維症 / 細胞増殖 / リプログラミング / ガドテル酸メグルミン / ガドジアミド / ガドリニウム造影剤 / ガドリニウム / トiPS細胞 / ブルーム遺伝子 / Loss Of Heterozygosity / 相同組換え / CRISPR/Cas9 / 遺伝性皮膚疾患 / revertant mosaicism / 膠原病 / モデルマウス / 脱毛症 / アトピー性皮膚炎 / トランスジェニックマウス / CD40リガンド / 表皮角化細胞 / 人工ヌクレアーゼ / ヒト / IgE / TH2サイトカイン / 蕁麻疹 / プロテアーゼ / IgE / STAT6 / M2マクロファージ / TH2サイトカイン / 痒疹 / 好塩基球 Less
  • Research Projects

    (11 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (8 People)
  •  siRNAによる血管型エーラス・ダンロス症候群の新規治療開発を目指したin vitro研究

    • Principal Investigator
      林 周次郎
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Dokkyo Medical University
  •  アトピー性皮膚炎におけるMAIT細胞の役割を明らかにするPrincipal Investigator

    • Principal Investigator
      井川 健
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Dokkyo Medical University
  •  Potential reprogramming of skin fibroblasts by gadolinium stimulation

    • Principal Investigator
      Hayashi Shujiro
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Dokkyo Medical University
  •  Examination of 'true' meanings of filaggrin mutation in human epidermal keratinocytes.Principal Investigator

    • Principal Investigator
      IGAWA KEN
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Dokkyo Medical University
      Tokyo Medical and Dental University
  •  Analysis of cutaneous lesion in collagen disease induced by intranuclear autoantibody.

    • Principal Investigator
      HIGUCHI Tetsuya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Toho University
  •  Establishments of the new forward genetic method using homologues recombination in human iPS cells

    • Principal Investigator
      Yoshimura Yasuhide
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Osaka University
  •  An establishment of novel treatment based for the pathogenesis of untreated allergic skin diseases

    • Principal Investigator
      Yokozeki Hiroo
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Tokyo Medical and Dental University
  •  induction from fibroblast to keratinocyte

    • Principal Investigator
      SATO HITOMI
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Dokkyo Medical University
  •  A trial for the clarification of the precise relationship between filaggrin gene mutation and atopic dermatitis by using human pluripotent stem cellPrincipal Investigator

    • Principal Investigator
      IGAWA Ken
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Tokyo Medical and Dental University
  •  Approaches of the new therapy development for atopic dermatitis by using RNA interferencePrincipal Investigator

    • Principal Investigator
      IGAWA Ken
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      Osaka University
      Tokyo Medical and Dental University
  •  アトピー性皮膚炎由来の表皮角化細胞における転写調節因子の解析Principal Investigator

    • Principal Investigator
      井川 健
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      Tokyo Medical and Dental University

All 2023 2019 2018 2016 2015 2014 2013 2012 2011 2010 2009 2006

All Journal Article Presentation

  • [Journal Article] Clinical features and morphology of collagen fibrils in patients with vascular Ehlers?Danlos based on electron microscopy2023

    • Author(s)
      Ishikawa Satoko、Hayashi Shujiro、Sairenchi Toshimi、Miyamoto Manabu、Yoshihara Shigemi、Kobashi Gen、Yamaguchi Tomomi、Kosho Tomoki、Igawa Ken
    • Journal Title

      Frontiers in Genetics

      Volume: 14

    • DOI

      10.3389/fgene.2023.1238209

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07773
  • [Journal Article] Case report: Mild phenotype of a patient with vascular Ehlers?Danlos syndrome and COL3A1 duplication mutation without alteration in the [Gly-X-Y] repeat sequence2023

    • Author(s)
      Hayashi Shujiro、Yamaguchi Tomomi、Kosho Tomoki、Igawa Ken
    • Journal Title

      Frontiers in Genetics

      Volume: 13

    • DOI

      10.3389/fgene.2022.1017446

    • Data Source
      KAKENHI-PROJECT-23K07773
  • [Journal Article] Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells2014

    • Author(s)
      Ken Igawaa, Chikara Kokubu, Kosuke Yusa, Kyoji Horie, Yasuhide Yoshimura, Kaori Yamauchi, Hirofumi Suemori, Hiroo Yokozeki, Masashi Toyoda, Nobutaka Kiyokawa, Hajime Okita, Yoshitaka Miyagawa, Hidenori Akutsu, Akihiro Umezawa, Ichiro Katayama, Junji Takeda.
    • Journal Title

      Stem Cells Transl Med

      Volume: 3 Issue: 9 Pages: 992-1001

    • DOI

      10.5966/sctm.2013-0179

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22310118, KAKENHI-PROJECT-24591651, KAKENHI-PROJECT-24615003, KAKENHI-PROJECT-25461665, KAKENHI-PROJECT-25640048, KAKENHI-PROJECT-24241064
  • [Journal Article] Gene silencing of STAT6 with siRNA ameliorates contact hyper sensitivity and allergic rhinitis.2011

    • Author(s)
      Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K, et al
    • Journal Title

      Allegy

      Volume: 66(1) Pages: 124-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791064
  • [Journal Article] Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis.2011

    • Author(s)
      Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K(10人中5番目)
    • Journal Title

      Allegy 66(1)

      Pages: 124-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791064
  • [Journal Article] 【アトピー性皮膚炎の正しい治療】アトピー性皮膚炎の新しい治療の展望2010

    • Author(s)
      井川健
    • Journal Title

      医薬ジャーナル 46(3)

      Pages: 994-998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791064
  • [Journal Article] Regulatory mechanisms of galectin-9 and eotaxin-3 synthesis in epidermal keratinocytes : possible involvement of galectin-9 in dermal eosinophilia of Th1-polarized skin inflammation.2006

    • Author(s)
      Igawa K, et al.
    • Journal Title

      Allergy 61(12)

      Pages: 1385-1385

    • Data Source
      KAKENHI-PROJECT-16790625
  • [Presentation] Anti-inflammatory effects of potassium iodide in sodium dodecyl sulphate-induced inflammatory murine skin through interleukin-10 regulation.2019

    • Author(s)
      Shujiro Hayashi. Satoko Ishikawa, Masami Koike, Tomoko Kaminaga, Yoichiro Hamasaki, Ken Igawa.
    • Organizer
      49th Annual ESDR Meeting. Bordeaux, 2019. 9.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08799
  • [Presentation] iPS細胞の基礎と臨床2018

    • Author(s)
      井川 健
    • Organizer
      第117回日本皮膚科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09759
  • [Presentation] To clarify the effect of the filaggrin gene mutation in keratinocytes by using CRISPR/Cas9 system and human induced pluripotent stem cells.2016

    • Author(s)
      Ken Igawa
    • Organizer
      The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2016-12-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09759
  • [Presentation] REMOVAL OF REPROGRAMMING TRANSGENES IMPROVES THE TISSUE RECONSTITUTION POTENTIAL OF KERATINOCYTES GENERATED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS.2015

    • Author(s)
      Igawa K. et al.
    • Organizer
      23rd World Congress of Dermatology 2015
    • Place of Presentation
      Vancouver(Canada)
    • Year and Date
      2015-06-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461665
  • [Presentation] A trial to clarify the effect of the filaggrin gene mutation to keratinocytes biology by using CRISPR/Cas9 system and human induced pluripotent stem cells.2015

    • Author(s)
      Igawa K. et al.
    • Organizer
      ESDR2015
    • Place of Presentation
      Rotterdam(Netherlands)
    • Year and Date
      2015-09-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461665
  • [Presentation] A trial to clarify the effect of the filaggrin gene mutation to keratinocytes biology by using CRISPR/Cas9 system and human induced pluripotent stem cells.2015

    • Author(s)
      Igawa K
    • Organizer
      European Society for Dermatological Research 2015
    • Place of Presentation
      ロッテルダム、オランダ
    • Year and Date
      2015-09-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09759
  • [Presentation] REMOVAL OF REPROGRAMMING TRANSGENES IMPROVES THE TISSUE RECONSTITUTION POTENTIAL OF KERATINOCYTES GENERATED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS.2015

    • Author(s)
      Igawa K
    • Organizer
      World Congress of Dermatology 2015
    • Place of Presentation
      バンクーバー、カナダ
    • Year and Date
      2015-06-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09759
  • [Presentation] アトピー性皮膚炎の病型と難治性皮膚病変 の関連に関する疫学調査2014

    • Author(s)
      野老翔雲、井川 健、戸倉新樹、宮地良樹、 片山一朗、佐藤貴浩、横関博雄
    • Organizer
      第26回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-05-09
    • Data Source
      KAKENHI-PROJECT-25461665
  • [Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line: Implication for therapeutic application.2013

    • Author(s)
      Igawa K
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh, Scotland
    • Data Source
      KAKENHI-PROJECT-24591651
  • [Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line: Implication for therapeutic application.2013

    • Author(s)
      井川 健
    • Organizer
      第8回 箱根カンファレンス
    • Place of Presentation
      淡路島
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591651
  • [Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line:Implication for therapeutic application.2013

    • Author(s)
      IGAWA K.
    • Organizer
      第8回 箱根カンファレンス
    • Place of Presentation
      兵庫県淡路島淡路夢舞台
    • Data Source
      KAKENHI-PROJECT-25461665
  • [Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line.2013

    • Author(s)
      IGAWA K., HORIE K., YUSA K., YOKOZEKI H., KATAYAMA I., TAKEDA. J.
    • Organizer
      Implication for therapeutic application. International Investigative Dermatology.
    • Place of Presentation
      Edinburgh, Scotland
    • Data Source
      KAKENHI-PROJECT-25461665
  • [Presentation] induced keratinocytes from transgene-free but not transgene-residual human induced pluripotent stem cells phenotypically resemble primary human keratinocytes.2012

    • Author(s)
      Ken IGAWA, Kyoji HORIE, Hiroo YOKOZEKI, Ichiro KATAYAMA, Junji TAKEDA.
    • Organizer
      The 42nd Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Venice, Italy
    • Data Source
      KAKENHI-PROJECT-24591651
  • [Presentation] A trial of in vitro reconstitution of human skin using transgene-free induced pluripotent stem cells.2012

    • Author(s)
      Ken IGAWA, Kyoji HORIE, Kosuke YUSA, Junji TAKEDA, Ichiro KATAYAMA
    • Organizer
      10th annual meeting of ISSCR
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-24591651
  • [Presentation] 重症アトピー性皮膚炎の新規治療2010

    • Author(s)
      井川健
    • Organizer
      第109回日本皮膚科学会総会教育講演
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-04-16
    • Data Source
      KAKENHI-PROJECT-21791064
  • [Presentation] 重症アトピー性皮膚炎の新規治療2010

    • Author(s)
      井川健
    • Organizer
      第109回日本皮膚科学会総会教育講演
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21791064
  • [Presentation] A therapeutic effect of STAT6 inhibition in atopic dermatitis2009

    • Author(s)
      Ken Igawa
    • Organizer
      Yonsei Cutaneous Biology Research Institute International Symposium 2009
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2009-09-19
    • Data Source
      KAKENHI-PROJECT-21791064
  • [Presentation] A therapeutic effect of ST AT6 inhibition in atopic dermatitis.2009

    • Author(s)
      Igawa K
    • Organizer
      Yonsei Cutaneous Biology Research Institute International Symposium 2009
    • Place of Presentation
      Seoul(招待講演)
    • Data Source
      KAKENHI-PROJECT-21791064
  • 1.  Hayashi Shujiro (00599871)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  Yokozeki Hiroo (90210608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  SATO HITOMI (00648090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  HIGUCHI Tetsuya (00334425)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  TSUBATA Takeshi (80197756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Yoshimura Yasuhide (60263307)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  宇賀神 つかさ (40581327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  堀江 恭二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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