IHARA Masafumi 猪原匡史

Researcher Number	00372590
Other IDs	https://orcid.org/0000-0002-7102-4048
Affiliation *help	2016 – 2018 : 国立研究開発法人国立循環器病研究センター, 病院, 部長 2016 : 国立循環器病研究センター, 脳血管内科, 医長 2015 : 国立研究開発法人国立循環器病研究センター, 病院, 医長 2013 – 2014 : 独立行政法人国立循環器病研究センター, 病院, 医長 2012 : 公益財団法人先端医療振興財団, 先端医療センター再生医療研究部, 副部長 … More
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Neurology / Structural biochemistry / Pathobiological dentistry/Dental radiology Except Principal Investigator Neurosurgery / Radiation science / Basic Section 10030:Clinical psychology-related / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 齲蝕原性細菌 / 脳循環障害 / シロスタゾール / アルツハイマー病 / 脳卒中 / 血管性認知症 / 脳神経疾患 / 内皮型一酸化窒素合成酵素 / 両側総頸動脈狭窄術 / タキシフォリン … More Except Principal Investigator 診断 / 脳アミロイドアンギオパチー / 単球機能 / 血圧 / 抑うつ / 脳出血 / TREM2 / 脳内神経ネットワーク / 肥満 / イメージング / 降圧薬 / 臨床 / 糖尿病 / 心理リハビリテーション / 研究者主導型臨床試験 / βアミロイド / 認知症 / 脳神経疾患 / 金属錯体 / 内科 / 国際共同無作為化比較試験 Less

TREM2・単球機能を標的とした糖尿病・肥満に伴う認知症予知指標・治療戦略の開発Ongoing
- Principal Investigator
  
  浅原哲子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Department of Clinical Research, National Hospital Organization Kyoto Medical Center
抑うつに対する音の両側性刺激の効果の基礎的研究Ongoing
- Principal Investigator
  
  山内美穂
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10030:Clinical psychology-related
- Research Institution
  National Cardiovascular Center Research Institute
Triple therapy prevention of Recurrent Intracerebral Disease EveNts TrialOngoing
- Principal Investigator
  
  豊田一則
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  National Cardiovascular Center Research Institute
Establishment of international liaison between medical doctors and dentists for the purpose of reduction of stroke in Nigeria and KenyaPrincipal InvestigatorOngoing
- Principal Investigator
  
  猪原匡史
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  National Cardiovascular Center Research Institute
口腔内細菌に起因する出血性脳卒中の病態理解とモデル動物の作成Principal InvestigatorOngoing
- Principal Investigator
  
  猪原匡史
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Cardiovascular Center Research Institute
細胞外タウ除去機構の破綻に基づくアルツハイマー病の病態解明と新規抗糖化療法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  猪原匡史
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Cardiovascular Center Research Institute
Development of nuclear medical imaging probes targeting cerebral amyloid antipathy
- Principal Investigator
  
  Ono Masahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
A study to elucidate the mechanism by which the longevity gene product SIRT1 confers neuroprotectionPrincipal Investigator
- Principal Investigator
  
  IHARA Masafumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Cardiovascular Center Research Institute
Regenerative therapy for Alzheimer's disease and cerebral amyloid angiopathyPrincipal Investigator
- Principal Investigator
  
  IHARA Masafumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  National Cardiovascular Center Research Institute
  Foundation for Biomedical Research and Innovation
  Kyoto University
Exploration of treatment of hereditary vascular dementia CADASIL using patient-derived iPS cells and its model micePrincipal Investigator
- Principal Investigator
  
  IHARA Masafumi
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyoto University
融合ナノプローブ薬剤送達システムを用いた脳虚血巣選択的オートファジー制御への挑戦Principal Investigator
- Principal Investigator
  
  猪原匡史
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyoto University
セプチン/脂質によるαシヌクレインポリマー/フィラメント形成機序に関する検討Principal Investigator
- Principal Investigator
  
  猪原匡史
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] モデル動物利用マニュアル.疾患モデルの作製と利用一循環器疾患2010
- Author(s)
  北徹, 堀内久徳, 柳田素子, 猪原匡史, 冨本秀和, 並河徹編
- Total Pages
  486
- Publisher
  (株)エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-22650073
[Book] 慢性脳低灌流モデル.北徹, 堀内久徳, 柳田素子, 猪原匡史, 冨本秀和, 並河徹編「モデル動物利用マニュアル. 疾患モデルの作製と利用-循環器疾患」(株)
- Author(s)
  猪原匡史, 冨本秀和
- Total Pages
  486
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy2017
- Author(s)
  Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, Harada-Shiba M, Kalaria RN, Fukushima M, Takahashi R, Ihara M
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume : 印刷中
- DOI
  10.1186/s40478-017-0429-5
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271
[Journal Article] Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment.2016
- Author(s)
  Watanabe I, Kuriyama N, Miyatani F, Nomura R, Naka S, Nakano K, Ihara M, Iwai K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Tamura A, Mizuno T, Akazawa K6, Takada A, Takeda K, Yamada K, Nakagawa M, Tanaka T, Kanamura N, Friedland RP, Watanabe Y.
- Journal Title
  
  Sci Rep
  
  Volume : 6 Pages : 1-5
- DOI
  10.1038/srep38561
- Peer Reviewed / Int'l Joint Research / Open Access
- Data Source
  KAKENHI-PROJECT-15K10318, KAKENHI-PROJECT-16K14573, KAKENHI-PROJECT-16H06277
[Journal Article] Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans2016
- Author(s)
  Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Tsuji M, Nagatsuka K, Kalaria RN, Iida H, Ihara M
- Journal Title
  
  J Am Heart Assoc
  
  Volume : 5
- DOI
  10.1161/JAHA.115.002757
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461867, KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26640034
[Journal Article] Influence of low-dose aspirin on cerebral amyloid angiopathy in mice2016
- Author(s)
  Hattori Y, Maki T, Saito S, Yamamoto Y, Nagatsuka K, Ihara M
- Journal Title
  
  J Alzheimers Dis
  
  Volume : -
- DOI
  10.3233/JAD-160013
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04271
[Journal Article] う蝕原因菌と脳出血の関連－脳口連関－．2016
- Author(s)
  殿村修一，仲野和彦，猪原匡史
- Journal Title
  
  日本歯科論評
  
  Volume : 76 Pages : 14-15
- Data Source
  KAKENHI-PROJECT-16K14573
[Journal Article] Frontal White Matter Hyperintensities, Clasmatodendrosis and Gliovascular Abnormalities in Ageing and Post-stroke Dementia2016
- Author(s)
  13.Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung’u MN, Foster V, Craggs LJL, Washida K, Okamoto Y, Thomas AJ, Polvikosk TM, Allan JM, Oakley AE, O’Brien JT, Horsburgh K, Ihara M, Kalaria RN
- Journal Title
  
  Brain
  
  Volume : 139 Pages : 242-258
- DOI
  10.1093/brain/awv328
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271
[Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory2016
- Author(s)
  Kitamura A, Saito S, Maki A, Ayaki T, Oishi N, Kalaria RN, Hattori Y, Yamamoto Y, Urushitani M, Horsburgh K, Fukuyama H, Takahashi R, Ihara M
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume : - Pages : 1592-1602
- DOI
  10.1177/0271678X15606717
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-15K09920, KAKENHI-PROJECT-26290023
[Journal Article] Hemisphere asymmetry of response to treatment in an Alzheimer’s disease mouse model.2016
- Author(s)
  Manousopoulou A, Saito S, Yamamoto Y, Al-Daghri NM, Ihara M, Carare RO, Garbis SD
- Journal Title
  
  J Alzheimers Dis.
  
  Volume : 21 Pages : 333-338
- DOI
  10.3233/JAD-151078
- Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26893337
[Journal Article] Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease2016
- Author(s)
  Ihara M, Yamamoto Y
- Journal Title
  
  Stroke
  
  Volume : 47 Pages : 554-560
- DOI
  10.1161/STROKEAHA.115.009627
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-16K18387
[Journal Article] Stroke Injury, cognitive Impairment and vascular dementia2016
- Author(s)
  Kalaria RN, Akinyemi R, Ihara M
- Journal Title
  
  Biochim Biophys Acta
  
  Volume : -
- DOI
  10.1016/j.bbadis.2016.01.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271
[Journal Article] The interaction between cerebrovascular disease and Alzheimer pathology.2016
- Author(s)
  Saito S, Ihara M
- Journal Title
  
  Curr Opin Psychiatry.
  
  Volume : 29 Pages : 168-173
- DOI
  10.1097/YCO.0000000000000239
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26893337
[Journal Article] SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.2015
- Author(s)
  Hattori Y, Okamoto Y, Nagatsuka K, Takahashi R, Kalaria RN, Kinoshita M, Ihara M
- Journal Title
  
  Neuroreport
  
  Volume : 26 Pages : 113-117
- DOI
  10.1097/WNR.0000000000000308
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26640034, KAKENHI-PLANNED-23111002
[Journal Article] Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer's Disease Brains2015
- Author(s)
  Matsumura K, Ono M, Kitada A, Watanabe H, Yoshimura M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume : 58 Pages : 7241-7257
- DOI
  10.1021/acs.jmedchem.5b00440
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01555, KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-14J05961
[Journal Article] Immunolocalisation of PDGFRβ and pericytes in CADASIL2015
- Author(s)
  Craggs LJL, Fenwick R, Oakley AE, Ihara M, Kalaria RN
- Journal Title
  
  Neuropath Appl Neurobiol
  
  Volume : 41 Pages : 557-570
- DOI
  10.1111/nan.12188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271
[Journal Article] Mild cognitive impairment: at the crossroad of neurodegeneration and vascular dysfunction.2015
- Author(s)
  Saito S, Yamamoto Y, Ihara M
- Journal Title
  
  Curr Alzheimer Res.
  
  Volume : 12 Pages : 507-512
- DOI
  10.2174/1567205012666150530202508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26893337
[Journal Article] Translation of pre-clinical studies into successful clinical trials for Alzheimer’s disease: what are the roadblocks and how can they be overcome?2015
- Author(s)
  Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y, Mudher A, Padjen AL, Mukaetova-Ladinska E, Ihara M, Srivastava E, Srivastava MVP, Masters CL, Kalaria RN, Anand A
- Journal Title
  
  J Alzheimer Dis
  
  Volume : 47 Pages : 815-843
- DOI
  10.3233/JAD-150136
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271
[Journal Article] microRNA-33 regulates ApoE lipidation and Amyloid-β metabolism in the brain.2015
- Author(s)
  Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, Kim J.
- Journal Title
  
  J Neurosci
  
  Volume : 35(44) Pages : 14717-26
- DOI
  10.1523/JNEUROSCI.2053-15.2015
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461144, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26293186
[Journal Article] A novel mouse model of subcortical infarcts with dementia.2015
- Author(s)
  Hattori Y, Enmi J, Kitamura A, Yamamoto Y, Saito S, Takahashi Y, Iguchi S, Tsuji M, Yamahara K, Nagatsuka K, Iida H, Ihara M
- Journal Title
  
  J Neurosci
  
  Volume : 35 Pages : 3915-3928
- DOI
  10.1523/JNEUROSCI.3970-14.2015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461867, KAKENHI-PROJECT-25640031
[Journal Article] Motor and cognitive impairment in a mouse model of ischemic carotid artery disease.2014
- Author(s)
  Hattori Y, Kitamura A, Tsuji M, Nagatsuka K, Ihara M
- Journal Title
  
  Neurosci Lett
  
  Volume : 581 Pages : 1-6
- DOI
  10.1016/j.neulet.2014.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640031
[Journal Article] Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study.2014
- Author(s)
  Ihara M, Nishino M, Taguchi A, Yamamoto Y, Hattori Y, Saito S, Takahashi Y, Tsuji M, Kasahara Y, Takata Y, Okada M
- Journal Title
  
  PloS ONE
  
  Volume : 9(2)
- DOI
  10.1371/journal.pone.0089516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid.2014
- Author(s)
  Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume : 1 Pages : 519-533
- DOI
  10.1002/acn3.79
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25640031
[Journal Article] 注目される脳小血管病による認知症2014
- Author(s)
  猪原匡史
- Journal Title
  
  Dementia Japan
  
  Volume : 28(1) Pages : 57-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] 注目される脳小血管病による認知症．2014
- Author(s)
  猪原匡史
- Journal Title
  
  Dementia Japan
  
  Volume : 28 Pages : 57-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.2014
- Author(s)
  Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M
- Journal Title
  
  Stroke
  
  Volume : 45 Pages : 3403-3411
- DOI
  10.1161/STROKEAHA.114.006265
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390292, KAKENHI-PROJECT-24791296, KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26640034, KAKENHI-PROJECT-22220003
[Journal Article] 高血糖とアルツハイマー病．2014
- Author(s)
  猪原匡史
- Journal Title
  
  医学のあゆみ
  
  Volume : 249 Pages : 545-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] An highly reproducible model of cerebralischemia/reperfusion with extended survival in CB-17 mice2014
- Author(s)
  Tsukamoto M, Sango. K, Niimi N, Yanagisawa H, Watabe K, Utsunomiya K.
- Journal Title
  
  Neuroscience Research
  
  Volume : 92 Pages : 80-85
- DOI
  10.1016/j.neures.2013.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500428, KAKENHI-PROJECT-22592271, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23500448, KAKENHI-PROJECT-25463159, KAKENHI-PROJECT-25640031
[Journal Article] Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke.2014
- Author(s)
  Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T.
- Journal Title
  
  Neuroscience.
  
  Volume : 263 Pages : 148-158
- DOI
  10.1016/j.neuroscience.2014.01.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23500448, KAKENHI-PROJECT-23791220, KAKENHI-PROJECT-24591617, KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26461630, KAKENHI-PROJECT-23590444
[Journal Article] White matter pathology and disconnection in the frontal lobe in CADASIL2014
- Author(s)
  Craggs LJ, Yamamoto Y, Ihara M, Fenwick R, Slade JY, Oakley A, Roeber S, Duering M, Kretzschmar H, Kalaria RN.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume : in press
- DOI
  10.1111/nan.12073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-12J07954, KAKENHI-PROJECT-23390233
[Journal Article] 注目される脳小血管病による認知症．2014
- Author(s)
  猪原匡史
- Journal Title
  
  Dementia Japan
  
  Volume : 28 Pages : 57-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640031
[Journal Article] 高血糖とアルツハイマー病．2014
- Author(s)
  猪原匡史
- Journal Title
  
  医学のあゆみ
  
  Volume : 249 Pages : 545-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640031
[Journal Article] A mouse model of chronic cerebral hypoperfusion characterizing features of cognitive impairment.2014
- Author(s)
  Ihara M, Taguchi A, Maki T, Washida K, Tomimoto H
- Journal Title
  
  Methods Mol Biol
  
  Volume : 1135 Pages : 95-102
- DOI
  10.1007/978-1-4939-0320-7_8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] 認知症における血管病の重要性．2013
- Author(s)
  猪原匡史
- Journal Title
  
  脳循環代謝
  
  Volume : 24 Pages : 83-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] Synthesis and Biological Evaluation of Novel Styryl Benzimidazole Derivatives as Probes for Imaging of Neurofibrillary Tangles in Alzheimer’s Disease.2013
- Author(s)
  Matsumura K, Ono M, Yoshimura M, Kimura H, Watanabe H, Okamoto Y, Ihara M, Takahashi R, Saji H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 21 Pages : 3356-3362
- DOI
  10.1016/j.bmc.2013.02.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-24659564, KAKENHI-PROJECT-25640031
[Journal Article] 認知症における血管病の重要性2013
- Author(s)
  猪原匡史
- Journal Title
  
  脳循環代謝
  
  Volume : 24(2) Pages : 83-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] 認知症の診断と治療を目指した小血管病の管理2013
- Author(s)
  猪原匡史
- Journal Title
  
  Brain and Nerve
  
  Volume : 65(7) Pages : 801-809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] Structure-activity Relationships and in vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques.2013
- Author(s)
  Yoshimura M, Ono M, Matsumura K, Watanabe H, Kimura H, Cui M, Nakamoto Y, Togashi K, Okamoto Y, Ihara M, Takahashi R, Saji H.
- Journal Title
  
  ACS Med Chem Lett
  
  Volume : 4 Pages : 596-600
- DOI
  10.1021/ml4000707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Experimental and clinical challenge for neuroregeneration following stroke.2013
- Author(s)
  Kasahara Y, Ihara M, Taguchi A.
- Journal Title
  
  Front Neurol Neurosci
  
  Volume : 32 Pages : 69-75
- DOI
  10.1159/000346416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Vascular and neurodegenerative pathways―will they meet?2013
- Author(s)
  Kalaria RN, Ihara M
- Journal Title
  
  Nat Rev Neurol
  
  Volume : 9(9) Pages : 487-488
- DOI
  10.1038/nrneurol.2013.164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Greater suitability of the Montreal Cognitive Assessment against the Mini-Mental State Examination in the detection of vascular cognitive impairment2013
- Author(s)
  Ihara M, Okamoto Y, Takahashi R
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume : 22 Issue : 6 Pages : 737-741
- Publisher
  Elsevier Inc.
- DOI
  10.1016/j.jstrokecerebrovasdis.2012.01.001
- PMID
  22306380
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-23650182
[Journal Article] Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer's Disease.2013
- Author(s)
  Ono M, Cheng Y, Kimura H, Watanabe H, Matsumura K, Yoshimura M, Iikuni S, Okamoto Y, Ihara M, Takahashi R, Saji H.
- Journal Title
  
  PLoS ONE
  
  Volume : 8
- DOI
  10.1371/journal.pone.0074104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Visualization of Lenticulostriate Arteries by Flow-Sensitive Black-Blood MR Angiography on a 1.5T MRI System: A Comparative Study between Subjects with and without Stroke.2013
- Author(s)
  Okuchi S
- Journal Title
  
  AJNR Am J Neuroradiol.
  
  Volume : 34 Pages : 780-784
- DOI
  10.3174/ajnr.A3310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-24591757, KAKENHI-PROJECT-25640031, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002
[Journal Article] 認知症における血管病の重要性．2013
- Author(s)
  猪原匡史
- Journal Title
  
  脳循環代謝
  
  Volume : 24 Pages : 83-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640031
[Journal Article] 認知症の診断と治療を目指した小血管病の管理2013
- Author(s)
  猪原匡史
- Journal Title
  
  Brain and Nerve
  
  Volume : 65 Pages : 801-809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640031
[Journal Article] Association of Physical Activity with the Visuospatial/Executive Functions of the Montreal Cognitive Assessment in Patients with Vascular Cognitive Impairment.2013
- Author(s)
  Ihara M, Okamoto Y, Hase Y, Takahashi R
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume : 22(7)
- DOI
  10.1016/j.jstrokecerebrovasdis.2012.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Vascular Risk Factors and Neurodegeneration in Ageing related Dementias:Alzheimer’s Disease and Vascular Dementia.2013
- Author(s)
  Akinyemi R, Mukaetova-Ladinska E, Attems J, Ihara M, Kalaria RN
- Journal Title
  
  Curr Alzheimer Res
  
  Volume : 10(6) Pages : 642-53
- DOI
  10.2174/15672050113109990037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Cilostazol improves cognitive function in patients with mild cognitive impairment: A retrospective analysis.2013
- Author(s)
  Taguchi A, Takata Y, Ihara M, Kasahara Y, Tsuji M, Nishino M, Stern D, Okada M
- Journal Title
  
  Psychogeriatrics
  
  Volume : 13(3) Pages : 164-169
- DOI
  10.1111/psyg.12021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031
[Journal Article] Cilostazol a phosphodiesterase in hibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia2012
- Author(s)
  Hase Y, Okamoto Y, Fujita Y, KitamuraA, Ito H, Maki T, Washida K, TakahashiR, Ihara M
- Journal Title
  
  Exp Neurol
  
  Volume : 233 Pages : 523-533
- DOI
  10.1016/j.expneurol.2011.11.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Selective white matter abnormalities in a novel rat model of vascular dementia2012
- Author(s)
  Kitamura A, Fujita Y, Oishi N, KalariaR N, Washida K, Maki T, Okamoto Y, HaseY, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M
- Journal Title
  
  Neurobiology of Aging
  
  Volume : 33 Issue : 5 Pages : 1012.e25-1012.e35
- Publisher
  Elsevier Inc.
- DOI
  10.1016/j.neurobiolaging.2011.10.033
- PMID
  22133276
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Environmental enrichment ameliorated high fat diet-induced Aβdeposition and memory deficit in APP transgenic mice2012
- Author(s)
  Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, ShimohamaS, Kihara T, Kinoshita A
- Journal Title
  
  Neurobiology of Aging
  
  Volume : 33 Issue : 5 Pages : 1011.e11-1011.e23
- Publisher
  Elsevier Inc.
- DOI
  10.1016/j.neurobiolaging.2011.10.028
- PMID
  22197104
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23591243, KAKENHI-PROJECT-23650182, KAKENHI-PUBLICLY-24111524
[Journal Article] Cerebral hypoperfusion induces microinfarcts in cerebral amyloid angiopathy2012
- Author(s)
  Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M
- Journal Title
  
  ActaNeuropathol
  
  Volume : 123(3) Pages : 381-394
- DOI
  10.1007/s00401-011-0925-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] 18F-labeled Phenyldiazenyl Benzothiazole for invivo Imaging of Neurofibrillary Tangles in Alzheimer's Disease Brains2012
- Author(s)
  Matsumura K, Ono M, Kimura H, Ueda M, Nakamoto Y, Togashi K, Okamoto Y, Ihara M, Takahashi R, Saji H
- Journal Title
  
  ACS Med Chem Lett
  
  Volume : 3(1) Pages : 58-62
- DOI
  10.1021/ml200230e
- Data Source
  KAKENHI-PROJECT-23650182
[Journal Article] Angiogenic roles of adrenomedullin through VEGF induction2011
- Author(s)
  Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R
- Journal Title
  
  Neuroreport
  
  Volume : 22 Pages : 442-447
- DOI
  10.1097/WNR.0b013e32834757e4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Angiogenic and vasoprotective effects of adreno medulin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011
- Author(s)
  Tomimoto H
- Journal Title
  
  Stroke
  
  Volume : 42(4) Pages : 1122-8
- DOI
  10.1161/STROKEAHA.110.603399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21256005, KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positiveinclusions2011
- Author(s)
  Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H
- Journal Title
  
  Neurology
  
  Volume : 77:1993-1995 Pages : 1993-1995
- DOI
  10.1212/WNL.0b013e31823a0cfc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590930, KAKENHI-PROJECT-22659171, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] The influence of chronic cerebral hypoperfusion on cognitive function and amyloid b metabolism in APP overexpressing mice2011
- Author(s)
  Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R
- Journal Title
  
  PLoS One
  
  Volume : 6 Issue : 1
- Publisher
  Public Library of Science(PLoS)
- DOI
  10.1371/journal.pone.0016567
- PMID
  21305033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233
[Journal Article] Co localization of 14-3-3 proteins with SOD1 in Lewy Body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model2011
- Author(s)
  Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R
- Journal Title
  
  PLoS One
  
  Volume : 6 Issue : 5
- Publisher
  Public Library of Science
- DOI
  10.1371/journal.pone.0020427
- PMID
  21655264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22590930, KAKENHI-PROJECT-22659171, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice.2011
- Author(s)
  Yamada M, Ihara M, et.al.
- Journal Title
  
  PLoS One
  
  Volume : 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice.2011
- Author(s)
  Maki T, Ihara M, et al.
- Journal Title
  
  Stroke
  
  Volume : 42 Pages : 1125-1131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] Selective white matter pathology induces a specific impairment in spatial working memory2011
- Author(s)
  Coltman R, Spain A, et al
- Journal Title
  
  Neurobiol Aging
  
  Volume : 32
- DOI
  10.1016/j.neurobiolaging.2010.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains2011
- Author(s)
  Ono M, Hayashi S, et al
- Journal Title
  
  ACS ChemNeurosci
  
  Volume : 2 Pages : 269-275
- DOI
  10.1021/cn200002t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains2011
- Author(s)
  Matsumura K, Ono M, et al
- Journal Title
  
  Med ChemComm
  
  Volume : 2 Pages : 596-600
- DOI
  10.1039/C1MD00034A
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Clinicopathological study on an ALS family with a heterozygous E478G optineurin mutation2011
- Author(s)
  Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, FujitaK, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, KajiR, Takahashi R, Kawakami H
- Journal Title
  
  Acta Neuropathol
  
  Volume : 122 Pages : 223-229
- DOI
  10.1007/s00401-011-0842-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22590930, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23650182
[Journal Article] Watershed Infarcts in a multiple microembolic model of monkey2011
- Author(s)
  Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
- Journal Title
  
  Neuroscience Letters
  
  Volume : 499 Issue : 2 Pages : 80-83
- Publisher
  Elsevier Ireland Ltd.
- DOI
  10.1016/j.neulet.2011.05.036
- PMID
  21640789
- Year and Date
  2011-07-20
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-21591106, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Lessons from amouse model characterizing features of vascular cognitive impairment with white matter changes2011
- Author(s)
  Ihara M, Tomimoto H
- Journal Title
  
  J Aging Res
  
  Volume : 2011 Pages : 978761-978761
- DOI
  10.4061/2011/978761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182
[Journal Article] Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to PPAR-γ activation in mice with chronic cerebral hypoperfusion.2010
- Author(s)
  Washida K, Ihara M, et al.
- Journal Title
  
  Stroke
  
  Volume : 41 Pages : 1798-1806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow.2010
- Author(s)
  Fujita Y, Ihara M, et al.
- Journal Title
  
  Stroke
  
  Volume : 41 Pages : 2938-2943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies.2010
- Author(s)
  Ihara M, Plvikoski TM, et al.
- Journal Title
  
  Acta Neuropathol
  
  Volume : 119 Pages : 579-589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] A mouse model characterizing features of vascular dementia with hippocampal atrophy.2010
- Author(s)
  Nishio K, Ihara M, et al.
- Journal Title
  
  Stroke
  
  Volume : 41 Pages : 1278-1284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] 脳血管障害による認知機能障害;Vascular cognitive impairment2010
- Author(s)
  猪原匡史
- Journal Title
  
  老年精神医学雑誌
  
  Volume : 22 Pages : 53-59
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] 脳血管障害に基づく認知機能障害の病態2010
- Author(s)
  猪原匡史, 岡本洋子, ら
- Journal Title
  
  脳卒中
  
  Volume : 32 Pages : 614-620
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] 亜急性に進行する発動性低下のみを呈した内包膝部branch atheromatous diseaseの一例2010
- Author(s)
  北村彰浩, 猪原匡史, ら
- Journal Title
  
  脳卒中
  
  Volume : 32 Pages : 384-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650073
[Journal Article] 高血糖とアルツハイマー病
- Author(s)
  猪原匡史
- Journal Title
  
  医学のあゆみ
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Journal Article] Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β -amyloid
- Author(s)
  Maki T, Okamoto Y, Carare R, Hase Y, Hattori Y, Hawkes C, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda, H, Taguchi A, Takahashi R, Miyakawa T, Kalaria R, Lo E, Arai K, Ihara M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume : (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Vascular Dementia2017
- Author(s)
  Masafumi Ihara
- Organizer
  International Stroke Conference
- Place of Presentation
  Houston, USA
- Year and Date
  2017-02-21
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K14573
[Presentation] Dental microbes and stroke/dementia.2016
- Author(s)
  Masafumi Ihara
- Organizer
  Brain Ageing and Dementia in LIMICS 2016
- Place of Presentation
  Nairobi, Kenya
- Year and Date
  2016-12-06
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K14573
[Presentation] 脳卒中の新たな危険因子－口腔内感染－．2016
- Author(s)
  猪原匡史
- Organizer
  日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K14573
[Presentation] Bone morphogenetic protein‐4 expression by pericytes correlates with white matter damage in dementing disorders2015
- Author(s)
  Masafumi Ihara
- Organizer
  Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Kobe
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04271
[Presentation] ドラッグ・リポジショニングの手法を用いた軽度認知障害に対する創薬戦略2015
- Author(s)
  猪原匡史
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H04271
[Presentation] Experimental evidence linking vascular factors to Alzheimer's disease2015
- Author(s)
  Masafumi Ihara
- Organizer
  Alzheimer's Association International Conference (AAIC)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271
[Presentation] Animal Model of VCI2015
- Author(s)
  Masafumi Ihara
- Organizer
  Vas-Cog International
- Place of Presentation
  Tokyo
- Year and Date
  2015-09-16
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04271
[Presentation] Vascular Cognitive Impairment2015
- Author(s)
  猪原匡史
- Organizer
  第20回認知神経科学会
- Place of Presentation
  東京
- Year and Date
  2015-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-15H04271
[Presentation] 血管病を標的とした認知症治療2015
- Author(s)
  猪原匡史
- Organizer
  第5回認知症予防学会
- Place of Presentation
  神戸
- Year and Date
  2015-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-15H04271
[Presentation] Symposium S(4) -1. Vascular Dementia and Its Associated Conditions-Vascular Cognitive Impairment (VCI) . Cerebral amyloid angiopathy and cognitive impairment2013
- Author(s)
  Ihara M
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] S2-5-2中枢神経疾患治療に対するトランスレーショナルリサーチの現状とその課題2013
- Author(s)
  Ihara M
- Organizer
  Novel mechanism and therapy to treat patient with dementia. Neuro2013
- Place of Presentation
  京都
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Bench to bedside : using mouse models to identify new treatment approaches for Alzheimer' s disease2013
- Author(s)
  Ihara M
- Organizer
  Invited lecture : 19th Southampton Neuroscience Group (SoNG) Meeting
- Place of Presentation
  Southampton, UK
- Year and Date
  2013-09-19
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Lessons from rodent models characterizing features of vascular cognitive impairment2013
- Author(s)
  Ihara M
- Organizer
  Minisymposium (Animal models of VCI) . Vas-Cog2013
- Place of Presentation
  Toronto, Canada
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of vascular cognitive impairment2013
- Author(s)
  Ihara M
- Organizer
  Plenary session (Special session on animal models of VCI) . Vas-Cog2013
- Place of Presentation
  Toronto, Canada
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] βアミロイドの血管依存性クリアランス2011
- Author(s)
  猪原匡史
- Organizer
  日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] モントリオール認知評価法MoCAはMMSEよりも皮質下血管性認知障害の検出感度が高い2011
- Author(s)
  猪原匡史
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Animal models for vascular cognitive impairment due to large vessel disease. Stroke Symposium in National University of Singapore2011
- Author(s)
  Masafumi Ihara
- Organizer
  Stroke Symposium in National University of Singapore
- Place of Presentation
  Singapore(招待講演)
- Year and Date
  2011-10-31
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Angiogenic and vasoprotectivc effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011
- Author(s)
  Masafumi Ihara
- Organizer
  Vas-Cog2011
- Place of Presentation
  France
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Animal models for vascular cognitive impairment due to large vessel disease2011
- Author(s)
  Masafumi Ihara
- Organizer
  STROKE SYMPOSIUM
- Place of Presentation
  Singapore(CELS Auditorium)
- Year and Date
  2011-10-31
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] Angiogenic andvasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011
- Author(s)
  Masafumi Ihara
- Organizer
  Vas-Cog
- Place of Presentation
  Lille, France
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] βアミロイドの血管依存性クリアランス2011
- Author(s)
  猪原匡史
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] 脳低灌流によりβアミロイドの血管依存性クリアランスが障害される2011
- Author(s)
  猪原匡史, 岡本洋子, 眞木崇州, 鷲田和夫, 伊東秀文, 冨本秀和, 高橋良輔
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] モントリオール認知評価法MoCAはMMSEよりも皮質下血管性認知障害の検出感度が高い2011
- Author(s)
  猪原匡史, 岡本洋子, 伊東秀文, 高橋良輔
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] 脳低灌流によりβアミロイドの血管依存性クリアランスが障害される2011
- Author(s)
  猪原匡史, 他
- Organizer
  日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 皮質下血管性認知症患者におけるモントリオール認知評価スコアと身体活動度との相関2011
- Author(s)
  猪原匡史
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] Animal models forvascular cognitive impairment due tolarge vessel disease2011
- Author(s)
  Masafumi Ihara
- Organizer
  Stroke Symposiumin National University of Singapore(Invited lecture)
- Place of Presentation
  Singapore
- Year and Date
  2011-10-31
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] Poster review session.2011
- Author(s)
  Masafumi Ihara
- Organizer
  Vas-Cog
- Place of Presentation
  Lille, France
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-23650182
[Presentation] A Mouse Model Characterizing Features of Vascular Dementia with Hippocampal Atrophy2010
- Author(s)
  Masafumi Ihara
- Organizer
  International Congress of Neuropathology (ICN2010)
- Place of Presentation
  Salzburg, Austria
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] 海馬萎縮を伴う血管性認知症の新規モデルマウス2010
- Author(s)
  猪原匡史
- Organizer
  日本脳循環代謝学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] Animal models to study Stroke and VCI.2010
- Author(s)
  Masafumi Ihara
- Organizer
  Annual Neurosciences Conference in Eastern Africa
- Place of Presentation
  Nairobi, Kenya
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] 混合型認知症の位置づけ, Vascular cognitive impairment(VCI)2010
- Author(s)
  猪原匡史
- Organizer
  日本認知症学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] シロスタゾールの血液脳関門保護効果-一過性局所脳虚血モデルにおけるVirchow血栓形成3要因への作用について-2010
- Author(s)
  猪原匡史
- Organizer
  日本脳循環代謝学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] CADASIL側頭極病変の成因に関する病理学的研究2010
- Author(s)
  猪原匡史, 山本由美, ら
- Organizer
  日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] シロスタゾールの血液脳関門保護効果:一過性局所脳虚血モデルから得られたエビデンス2010
- Author(s)
  猪原匡史
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] 脳血管障害に基づく認知機能障害の病態2010
- Author(s)
  猪原匡史
- Organizer
  日本脳卒中学会
- Place of Presentation
  盛岡
- Year and Date
  2010-04-15
- Data Source
  KAKENHI-PROJECT-22650073
[Presentation] 「長寿遺伝子」SIRT1はeNOSを脱アセチル化することで脳低灌流侵襲に対する抵抗性を賦与する
- Author(s)
  猪原匡史
- Organizer
  脳卒中学会
- Place of Presentation
  広島
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] 「血管病としての認知症」
- Author(s)
  猪原匡史
- Organizer
  Vas-Cog Japan
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] シロスタゾールによる血管依存性βアミロイドクリアランスの促進．
- Author(s)
  猪原匡史
- Organizer
  脳循環代謝学会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] Symposium S（4）-1.Vascular Dementia and Its Associated Conditions-Vascular Cognitive Impairment （VCI）．Cerebral amyloid angiopathy and cognitive impairment．
- Author(s)
  Masafumi Ihara.
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] S2-5-2中枢神経疾患治療に対するトランスレーショナルリサーチの現状とその課題．
- Author(s)
  Masafumi Ihara.
- Organizer
  Novel mechanism and therapy to treat patient with dementia. Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] 認知症における脳血管病変
- Author(s)
  猪原匡史
- Organizer
  第3回VAS-COG Japan 2012
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 小血管病における虚血性線条体障害：11C-フルマゼニルPETによる解析
- Author(s)
  猪原匡史
- Organizer
  第5回J-CAN (Japanese Consortium for Age-related Neurodegenerative disorders) 2012
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] シンポジウム１．血管性認知症の最先端「血管性認知症とAlzheimer病理」
- Author(s)
  猪原匡史
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 血管病としての認知症～その制圧へ向けた試み～
- Author(s)
  猪原匡史
- Organizer
  第3回VAS-COG Japan 2012
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical
- Author(s)
  Masafumi Ihara
- Organizer
  World Stroke Congress
- Place of Presentation
  Brazilia
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Animal models of brain hypoperfusion and cognitive impairment
- Author(s)
  Masafumi Ihara
- Organizer
  BRAIN AGEING AND DEMENTIA IN DEVELOPING COUNTRIES 2012
- Place of Presentation
  Nairobi
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 皮質下血管性認知症患者におけるモントリオール認知評価スコアと身体活動度との相関
- Author(s)
  猪原匡史
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 認知症患者における抗血栓療法の有効性と安全性に関する分子病理学的検討
- Author(s)
  猪原匡史
- Organizer
  第37回日本脳卒中学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 「血管病としての認知症」
- Author(s)
  猪原匡史
- Organizer
  Vas-Cog Japan
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] S2-5-2中枢神経疾患治療に対するトランスレーショナルリサーチの現状とその課題．
- Author(s)
  Masafumi Ihara.
- Organizer
  Novel mechanism and therapy to treat patient with dementia. Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Lessons from rodent models characterizing features of vascular cognitive impairment.
- Author(s)
  Masafumi Ihara.
- Organizer
  Minisymposium (Animal models of VCI). Vas-Cog2013
- Place of Presentation
  Toronto
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] 「認知症の発症にかかわる脳血管の機能」．
- Author(s)
  猪原匡史
- Organizer
  脳心血管抗加齢研究会2013
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] シロスタゾールによる血管依存性βアミロイドクリアランスの促進．
- Author(s)
  猪原匡史
- Organizer
  脳循環代謝学会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Bench to bedside: using mouse models to identify new treatment approaches for Alzheimer’s disease.
- Author(s)
  Masafumi Ihara.
- Organizer
  Invited lecture: 19th Southampton Neuroscience Group (SoNG) Meeting
- Place of Presentation
  Southampton
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Symposium S（4）-1.Vascular Dementia and Its Associated Conditions-Vascular Cognitive Impairment （VCI）．Cerebral amyloid angiopathy and cognitive impairment．
- Author(s)
  Masafumi Ihara.
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical
- Author(s)
  Masafumi Ihara
- Organizer
  3rd CAA meeting (Plenary lecture)
- Place of Presentation
  Leiden
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] シンポジウム5「血管性認知障害」血管性認知障害の病態－モデル動物を用いて明らかとなった知見－
- Author(s)
  猪原匡史
- Organizer
  第39回日本脳卒中学会総会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23390233
[Presentation] Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of vascular cognitive impairment.
- Author(s)
  Masafumi Ihara.
- Organizer
  Plenary session (Special session on animal models of VCI). Vas-Cog2013
- Place of Presentation
  Toronto
- Invited
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] Lessons from rodent models characterizing features of vascular cognitive impairment.
- Author(s)
  Masafumi Ihara.
- Organizer
  Minisymposium (Animal models of VCI). Vas-Cog2013
- Place of Presentation
  Toronto
- Invited
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] Bench to bedside: using mouse models to identify new treatment approaches for Alzheimer’s disease.
- Author(s)
  Masafumi Ihara.
- Organizer
  Invited lecture: 19th Southampton Neuroscience Group (SoNG) Meeting
- Place of Presentation
  Southampton
- Invited
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] シンポジウム5「血管性認知障害」血管性認知障害の病態－モデル動物を用いて明らかとなった知見－
- Author(s)
  猪原匡史
- Organizer
  第39回日本脳卒中学会総会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] 「認知症の発症にかかわる脳血管の機能」．
- Author(s)
  猪原匡史
- Organizer
  脳心血管抗加齢研究会2013
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-25640031
[Presentation] Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of vascular cognitive impairment.
- Author(s)
  Masafumi Ihara.
- Organizer
  Plenary session (Special session on animal models of VCI). Vas-Cog2013
- Place of Presentation
  Toronto
- Invited
- Data Source
  KAKENHI-PROJECT-23390233

1. 飯田秀博 (30322720)

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# of Collaborated Products : 1results
2. 仲野和彦 (00379083)

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# of Collaborated Products : 2results
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# of Collaborated Products : 9results
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28. MATSUMURA Kenji

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34. TAKAHASHI RYOSUKE

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35. MOMOTA Yoshihiro

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36. MATSUYAMA Tomohiro

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37. SATO Yoshiaki

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38. YAMAHARA Kenichi

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39. TSUHI MASAHIRO

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40. KANAGAKI Mitsunori

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41. OKADA Tomohisa

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65. 脇田英明

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IHARA Masafumi 猪原 匡史

Research Projects

Research Products

Co-Researchers

TREM2・単球機能を標的とした糖尿病・肥満に伴う認知症予知指標・治療戦略の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抑うつに対する音の両側性刺激の効果の基礎的研究Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Triple therapy prevention of Recurrent Intracerebral Disease EveNts TrialOngoing

Principal Investigator

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Research Category

Research Field

Research Institution

Establishment of international liaison between medical doctors and dentists for the purpose of reduction of stroke in Nigeria and KenyaPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔内細菌に起因する出血性脳卒中の病態理解とモデル動物の作成Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞外タウ除去機構の破綻に基づくアルツハイマー病の病態解明と新規抗糖化療法の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Development of nuclear medical imaging probes targeting cerebral amyloid antipathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study to elucidate the mechanism by which the longevity gene product SIRT1 confers neuroprotectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regenerative therapy for Alzheimer's disease and cerebral amyloid angiopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of treatment of hereditary vascular dementia CADASIL using patient-derived iPS cells and its model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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融合ナノプローブ薬剤送達システムを用いた脳虚血巣選択的オートファジー制御への挑戦Principal Investigator

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セプチン/脂質によるαシヌクレインポリマー/フィラメント形成機序に関する検討Principal Investigator

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[Book] モデル動物利用マニュアル.疾患モデルの作製と利用一循環器疾患2010

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IHARA Masafumi 猪原匡史