Hirota Keiko 廣田恵子

… Alternative Names

HIROTA Keiko 廣田恵子

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Researcher Number	00375370
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 東京女子医科大学, 医学部, 講師 2015 – 2017: 筑波大学, 生命環境系, 助教 2014: 筑波大学, 生命領域学際研究センター, 助教 2011: 筑波大学, 生命環境系, 助教 2010: University of Tsukuba, 生命環境科学研究科, 研究員 … More 2009: 筑波大学, 大学院・生命環境科学研究科, 助手 2007 – 2009: University of Tsukuba, 大学院・生命環境科学研究科, 研究員 2006: 筑波大学, 大学院生命環境科学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Applied biochemistry / Applied molecular and cellular biology / Basic Section 38060:Applied molecular and cellular biology-related Except Principal Investigator Biological Sciences / Biological Sciences
Keywords	Principal Investigator 線虫 / 寿命 / In vivo LUC / glucose-6-phosphatase / 糖代謝 / 転写制御 / C. elegans / 排泄 / 排泄リズム / SAM合成酵素 … More / tRNA / 分子遺伝学 / 栄養 / メチオニン回路 / 食餌 / メチオニン代謝 / FOXO / インスリン / HMGA / Foxol / NHF4 / in vivo LUC assay / insulin / glucokinase / glucose-6-phoshatase / FOXO1 / HNF4 … More Except Principal Investigator メチル化 / 老化 / ストレス耐性 / -adenosylmethionine / 寿命 / 栄養 / メチオニン代謝 / LC-MS/MS / 転写 / アセチルCoA / S-adenosylmethionine / 線虫 / S-アデノシルメチオニン / コアクチベーター / EWS / 脱アセチル化 / インスリン応答性 / アルギニンメチル化酵素 / グリシン-アルギニンタンパク質 / アセチルか / タンパク質修飾 / E3リガーゼ / アレルギンメチル化 / 複製 / 修復 / UV損傷 / 酸化ストレス / 複合体精製 / フォークヘッド / 食シグナル / アルギニンメチル化コード / アルギニンメチル化 / ユビキチン化 / アセチル化 / リン酸化 / フォークヘッド転写因子 / 翻訳後修飾 Less

線虫C. elegansにおける排泄リズムの制御と消化・寿命への影響Principal Investigator
- Principal Investigator
  
  廣田恵子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Tokyo Women's Medical University
Functional roles of initiator methionine tRNAPrincipal Investigator
- Principal Investigator
  
  Hirota Keiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Tokyo Women's Medical University
  University of Tsukuba
Analysis of short-term starvation-induced longevity via methionine metabolismPrincipal Investigator
- Principal Investigator
  
  HIROTA Keiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  University of Tsukuba
Crosstalk of transcriptional status and amino acid metabolism
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
The role of HMGA1 for the G6Pase gene transcriptionPrincipal Investigator
- Principal Investigator
  
  HIROTA Keiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
Analysis for HNF-4-mediated transcriptional regulation in response to insulin stimulation in the liverPrincipal Investigator
- Principal Investigator
  
  HIROTA Keiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
Elucidation of DECODE cycle that regulates homeostasis mediated by protein modification.
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba

[Book] 遺伝子制御の新たな主役栄養シグナル2016
- Author(s)
  廣田恵子、深水昭吉
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26450119
[Journal Article] SAMS-1 is required for the normal defecation motor program in Caenorhabditis elegans.2024
- Author(s)
  Hirota K, Matsuoka M.
- Journal Title
  
  MicroPublication Biology
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05964
[Journal Article] N-acetylcysteine restores the cadmium toxicity of Caenorhabditis elegans2021
- Author(s)
  Hirota Keiko、Matsuoka Masato
- Journal Title
  
  BioMetals
  
  Volume: 34 Issue: 5 Pages: 1207-1216
- DOI
  10.1007/s10534-021-00322-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10582, KAKENHI-PROJECT-20K05964
[Journal Article] Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans.2019
- Author(s)
  Hada Kazumasa、Hirota Keiko、Inanobe Ai、Kako Koichiro、Miyata Mai、Araoi Sho、Matsumoto Masaki、Ohta Reiya、Arisawa Mitsuhiro、Daitoku Hiroaki、Hanada Toshikatsu、Fukamizu Akiyoshi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294 Issue: 9 Pages: 3091-3099
- DOI
  10.1074/jbc.ra118.004726
- NAID
  120007133475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K07746, KAKENHI-PROJECT-17K08193, KAKENHI-PROJECT-17K19919, KAKENHI-PROJECT-17K15623, KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-16H05154, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-18H04260, KAKENHI-PROJECT-15KT0063
[Journal Article] rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans2018
- Author(s)
  Yokoyama Wataru、Hirota Keiko、Wan Huahua、Sumi Naoaki、Miyata Mai、Araoi Sho、Nomura Naoto、Kako Koichiro、Fukamizu Akiyoshi
- Journal Title
  
  J. Biochem.
  
  Volume: 印刷中 Issue: 6 Pages: 465-474
- DOI
  10.1093/jb/mvy018
- NAID
  40021579911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K07746, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-17J00231, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450119, KAKENHI-PROJECT-16K15087
[Journal Article] The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans2018
- Author(s)
  Araoi Sho、Daitoku Hiroaki、Yokoyama Atsuko、Kako Koichiro、Hirota Keiko、Fukamizu Akiyoshi
- Journal Title
  
  J. Biochem.
  
  Volume: 印刷中 Issue: 5 Pages: 433-440
- DOI
  10.1093/jb/mvy012
- NAID
  40021555333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K07746, KAKENHI-PROJECT-17K08193, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450119, KAKENHI-PROJECT-16K15087
[Journal Article] PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans.2017
- Author(s)
  Kanou A., Kako K., Hirota K., and Fukamizu A.
- Journal Title
  
  J. Biochem.
  
  Volume: 161 Issue: 2 Pages: 231-235
- DOI
  10.1093/jb/mvw066
- NAID
  40021133516
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450119
[Journal Article] Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.2017
- Author(s)
  Hirota K., Shigekawa C., Araoi S., Sha L., Inagawa T., Kanou A., Kako K., Daitoku H., and Fukamizu A.
- Journal Title
  
  J. Biochem.
  
  Volume: 印刷中 Issue: 6 Pages: 521-527
- DOI
  10.1093/jb/mvw101
- NAID
  40021278532
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450119, KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K08193, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-16K15087
[Journal Article] The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier.2015
- Author(s)
  Komura-Kawa T, Hirota K, Shimada-Niwa Y, Yamauchi R, Shimell M, Shinoda T, Fukamizu A, O'Connor MB, Niwa R.
- Journal Title
  
  PLoS Genetics
  
  Volume: 11 Issue: 12 Pages: e1005712-e1005712
- DOI
  10.1371/journal.pgen.1005712
- NAID
  120007127896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450119, KAKENHI-PROJECT-26840074
[Journal Article] Asymmetric arginine dimethylation determines lifespan in C. elegans by regulating forkhead transcription factor DAF-162011
- Author(s)
  Takahashi Y, Daitoku H, Hirota, K., Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Watanabe S, Yamagata K, Yasuda K, Ishii N and Fukamizu A
- Journal Title
  
  Cell Metab
  
  Volume: 13 Pages: 505-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780307
[Journal Article] Transcriptional regulation of energy metabolism in the liver2010
- Author(s)
  Hirota, K. and Fukamizu, A
- Journal Title
  
  J. Recept. Signal Transduct. review
  
  Volume: 30 Pages: 403-409
- Data Source
  KAKENHI-PROJECT-21780307
[Journal Article] A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities2010
- Author(s)
  Oishi, T., Date, S., Shimamoto, Y., Saito, T., Hirota, K., Sugaya, T., Kon, Y., Fukamizu, A., Tanimoto, K
- Journal Title
  
  J. Recept. Signal Transduct
  
  Volume: 30 Pages: 484-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780307
[Journal Article] A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.2008
- Author(s)
  Hirota, K. , Sakamaki, J. , Ishida, J. , Shimamoto, Y. , Nishihara, S. , Komada, N. , Ohta, K. , Yamamoto, M. , Tanimoto, K. , and Fukamizu, A.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 32432-32441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780247
[Journal Article] A combination of HNF-4 and Foxol is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding2008
- Author(s)
  Hirota, K
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 32432-32441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] A combination of.HNF-4 and Foxol is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.2008
- Author(s)
  Hirota, K., Sakamaki, J., Ishida, J., Shimamoto, Y., Nishihara ; S., Komada, N., Ohta, K., Yamamoto, M., T animoto, K., and Fukamizu, A.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 32432-32441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780247
[Journal Article] A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.2008
- Author(s)
  Hirota K, Sakamaki JI, Ishida J, Shimamoto Y, Nishihara S, Kodama N, Ohta K, Yamamoto M, Tanimoto K, Fukamizu A
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 32432-32441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner.2007
- Author(s)
  Hirota, K. , Yamagata K, Yoshimochi K, Daitoku H, , Fukamizu A.
- Journal Title
  
  Int J Mol Med. 19
  
  Pages: 751-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780247
[Journal Article] Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner.2007
- Author(s)
  Yamagata K, Yoshimochi K, Daitoku H, Hirota K, Fukamizu A.
- Journal Title
  
  Int J Mol Med. 19
  
  Pages: 751-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780247
[Journal Article] Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner.2007
- Author(s)
  Yamagata K, Yoshimochi K, Daitoku H, Hirota K, Fukamizu, A.
- Journal Title
  
  Int. J. Mol. Med. 19
  
  Pages: 751-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination.2005
- Author(s)
  Shimizu T, Oishi T, Omori A, Sugiura A, Hirota K, Aoyama H, Saito T, Sugaya T, Kon Y, Engel JD, Fukamizu A, Tanimoto K.
- Journal Title
  
  Mol. Cell. Biol. 25
  
  Pages: 2938-2945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promototer.2005
- Author(s)
  Fukamizu, A., Hirota, K.
- Journal Title
  
  Int.J.Mol.Med. 15
  
  Pages: 487-490
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Mutation analysis of HNF-4 binding sites in the human glucose- 6-phosphatase promoter.2005
- Author(s)
  Hirota K, Aoyama H, Fukamizu, A.
- Journal Title
  
  Int. J. Mol. Med. 15
  
  Pages: 487-490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.2005
- Author(s)
  Nakahara M, Furuya N, Takagi K, Sugaya T, Hirota K, Fukamizu A, Kanda T, Fujii H, Sato R.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 42283-42289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] 線虫Caenorhabditis elegansの排泄リズムに栄養代謝が及ぼす影響2022
- Author(s)
  廣田恵子、松岡雅人
- Organizer
  日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-20K05964
[Presentation] The role of phosphoethanolamine methyltransferase-1 in regulating the lifespan of Caenorhabditis elegans2020
- Author(s)
  HIROTA Keiko, KATADA Eriko, ISHIHARA Seiji, KOJIMA Mariko, KAKO Koichiro, FUKAMIZU Akiyoshi
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07746
[Presentation] T07A9.8 is required for the m1A modification at position 674 in 26S rRNA in C. elegans2019
- Author(s)
  Hirota K., Yokoyama W., Wan H., Sumi N., Miyata M., Araoi S., Nomura N., Kako K., and Fukamizu A.
- Organizer
  22nd International C. elegans Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07746
[Presentation] Dietary methionine influences the establishment of the germ stem cell pool mediated by sams-12018
- Author(s)
  Hirota K., Yamauchi R., Kojima M., Zhao X., Miyata M., Kako K., Fukamizu A.
- Organizer
  Asia-Pacific Worm Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07746
[Presentation] 線虫 Caenorhabditis elegans を用いたメチル化酵素・PMT-1 の S-adenosylmethioine 代謝への影響2016
- Author(s)
  形田恵理子, 廣田　恵子, 角直亮, 石原誠司, 小島真梨子, 加香孝一郎 , 深水昭吉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26450119
[Presentation] Effects of Dietary Restriction on Reproduction in C. elegans2016
- Author(s)
  Rieko Yamauchi、Keiko Hirota、Xu Zhao、Koichirou Kako、Akiyoshi Fukamizu
- Organizer
  Tsukuba Global Science Week
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450119
[Presentation] タンパク質アルギニンモノメチル化酵素の探索2015
- Author(s)
  狩野　明彦、加香　孝一郎、廣田　恵子、深水　昭吉
- Organizer
  平成27年度「転写代謝システム」領域班会議
- Place of Presentation
  熊本県熊本市　菊南温泉ユウベホテル
- Year and Date
  2015-06-15
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Citric acid is required for embryonic development in Caenorhabditis elegans2015
- Author(s)
  波田一誠，稲野辺愛，廣田恵子，加香孝一郎，深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-05
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫を用いたタンパク質アルギニンメチル基転移酵素の探索2015
- Author(s)
  狩野明彦、加香孝一郎、廣田恵子、深水昭吉
- Organizer
  第38回分子生物学会年会・第88回精化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26450119
[Presentation] 線虫を用いたﾀﾝﾊﾟｸ質ｱﾙｷﾞﾆﾝﾒﾁﾙ基転移酵素の探索2015
- Author(s)
  狩野　明彦、加香　孝一郎、廣田　恵子、深水　昭吉
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] phosphoethanolamine methyltransferase-1トランスジェニック線虫における長寿経路の探索2015
- Author(s)
  形田　恵理子、廣田　恵子、石原　誠司、小島　真梨子、加香　孝一郎、深水　昭吉
- Organizer
  平成27年度「転写代謝システム」領域班会議
- Place of Presentation
  熊本県熊本市　菊南温泉ユウベホテル
- Year and Date
  2015-06-15
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫におけるSAM代謝2015
- Author(s)
  廣田　恵子、形田　恵理子、石原　誠司、小島　真梨子、加香　孝一郎、深水　昭吉
- Organizer
  平成27年度「転写代謝システム」領域班会議
- Place of Presentation
  熊本県熊本市　菊南温泉ユウベホテル
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] アルギニンN-メチル基転移酵素の探索2015
- Author(s)
  狩野明彦，加香孝一郎，廣田恵子，深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-05
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 生殖系列におけるメチオニン代謝の機能解析2015
- Author(s)
  山内理恵子、廣田恵子、徐照、加香孝一郎、深水昭吉
- Organizer
  第38回分子生物学会年会・第88回精化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26450119
[Presentation] 長寿変異体における転写因子DAF-16の転写活性化能の評価2015
- Author(s)
  新生翔, 大徳浩照, 金子悠太, 廣田恵子, 深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 生殖系列におけるメチオニン代謝の機能解析2015
- Author(s)
  山内　理恵子、廣田　恵子、徐　照、加香　孝一郎、深水　昭吉
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫Caenorhabditis elegansの初期胚におけるクエン酸の役割2015
- Author(s)
  波田　一誠、稲野辺　愛、加香　孝一郎、廣田　恵子、深水　昭吉
- Organizer
  平成27年度「転写代謝システム」領域班会議
- Place of Presentation
  熊本県熊本市　菊南温泉ユウベホテル
- Year and Date
  2015-06-15
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 食餌性メチオニン制限がメチオニン量及び S-adenosyl-L-methionine量へ与える影響2015
- Author(s)
  山内理恵子、廣田恵子、徐照、加香孝一郎、大徳浩照、深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 食餌性メチオニン制限によるメチオニン及び S-adenosyl-L-methionine への影響2014
- Author(s)
  山内理恵子、廣田恵子、徐照、飯塚慧、大徳浩照、加香孝一郎、深水昭吉
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫Caenorhabditis elegans におけるphosphoethanolamine methyltransferase-1 の SAM代謝への影響2014
- Author(s)
  石原誠司、廣田恵子、加香孝一郎、深水昭吉
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫 Caenorhabditis elegans の胚における TCA 回路の代謝フラックスとその機能2014
- Author(s)
  Hada K, Kako K, Hirota K, Fukamizu A.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都府京都市　国立京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Dietary methionine restriction in axenic medium decreases both methionine and S-adenosyl-L-methionine levels. 6th Asia-pacific C.elegans Meeting2014
- Author(s)
  Yamauchi, R., Hirota, K., Xu, Z., Iizuka, K., Daitoku, H., Kako, K., Fukamizu, A.
- Organizer
  6th Asia-pacific C.elegans Meeting
- Place of Presentation
  奈良県奈良市　奈良県新公会堂
- Year and Date
  2014-07-15
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫Caenorhabditis elegans の初期胚における代謝物質の同定2014
- Author(s)
  波田一誠，加香孝一郎，廣田恵子，深水昭吉
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫C.elegansにおける転写因子DAF-16の新たな活性評価系の確立2014
- Author(s)
  新生翔、大徳浩照、金子悠太、廣田恵子、深水昭吉
- Organizer
  新学術領域「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  群馬 (舌切雀のお宿　磯部ガーデン)
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫C.elegansを用いたSAM量を制御するメチル化酵素の同定2014
- Author(s)
  小島真梨子、廣田恵子、加香孝一郎、大徳浩照、深水昭吉
- Organizer
  新学術領域「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  群馬 (舌切雀のお宿　磯部ガーデン)
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫C.elegansにおける短期絶食による寿命延長メカニズムの解析2014
- Author(s)
  作田元気、廣田恵子、加香孝一郎、大徳浩照、深水昭吉
- Organizer
  新学術領域「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  群馬 (舌切雀のお宿　磯部ガーデン)
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Identification of methyltransferases responsible for regulating the S-adenosylmethionine (SAM) levels in Caenorhabditis elegans.2013
- Author(s)
  Kojima, M., Hirota, K., Kako, K., Daitoku, H. and Fukamizu, A.
- Organizer
  兵庫（淡路夢舞台国際会議場）
- Place of Presentation
  兵庫（淡路夢舞台国際会議場）
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] S-adenosyl-L-methionine synthetase-1 (SAMS-1) regulates short-term-starvation-induced lifespan extension in Caenorhabditis elegans2013
- Author(s)
  Sakuta, G., Hirota, K., Takahashi, Y., Daitoku, H. Kako, K. and Fukamizu, A.
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  兵庫（淡路夢舞台国際会議場）
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Functional analysis for histidine protein methyltransferase in Caenorhabditis elegans.2013
- Author(s)
  Ishihara, S., Hirota, K., Kako, K., Tanaka, Y., Daitoku, H. Takahashi, Y. and Fukamizu, A.
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  兵庫（淡路夢舞台国際会議場）
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] S-adenosylmethionine synthetase SAMS-1 regulates brood size in C. elegans2011
- Author(s)
  Hiroko Tamiya, Keiko Hirota, Yuta Takahashi, Hiroaki Daitoku, Naoaki Ishii, Akiyoshi Fukamizu
- Organizer
  18^<th>International C. elegans Meeting
- Place of Presentation
  カリフォルニア州,(米国)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] S-adenosyl-L-methionine量の変化に伴ったヒストンメチル化の解析2011
- Author(s)
  飯塚慧, 廣田恵子, 大徳浩照, 深水昭吉
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] Asymmetric Arginine Dimethylation Determines Lifespan in C. elegans by Regulating Forkhead Transcription Factor DAF-162011
- Author(s)
  Yuta Takahashi, Hiroaki Daitoku, Keiko Hirota, Hiroko Tamiya, Atsuko Yokoyama, Kayo Yasuda, Naoaki Ishii and Akiyoshi Fukamizu
- Organizer
  18^<th> International C. elegans Meeting
- Place of Presentation
  カリフォルニア州,(米国)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] C.elegansにおけるアルギニンメチル化酵素PRMT-1の寿命制御機構の解明2011
- Author(s)
  高橋悠太, 大徳浩照, 廣田恵子, 安田佳代, 石井直明, 深水昭吉
- Organizer
  第15回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] 線虫のS-adenosylmethionine合成酵素遺伝子欠損変異体における熱耐性に関する研究2011
- Author(s)
  萩原彩乃, 廣田恵子, 高橋悠太, 田宮寛子, 渡辺哲史, 大徳浩照, 深水昭吉
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] 線虫S-adenosylmethionine synthetase-1の産卵数制御機構の解析2011
- Author(s)
  田宮寛子, 廣田恵子, 高橋悠太, 大徳浩照, 石井直明, 深水昭吉
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] 線虫のS-adenosylmethionine合成酵素sams-1の機能解析2010
- Author(s)
  田宮寛子, 廣田恵子, 高橋悠太, 渡辺哲史, 大徳浩照, 石井直明, 深水昭吉
- Organizer
  日本分子生物学会・生化学学会合同大会
- Place of Presentation
  兵庫
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] Caenorhabditis elegansにおける転写因子DAF-16のアルギニンメチル化酵素による制御機構の解明2009
- Author(s)
  高橋悠太, 大徳浩照, 山形一行, 廣田恵子恵子
- Organizer
  日本生化学会関東支部例会「若手が担う次世代型生化学研究」
- Place of Presentation
  茨城
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] 糖代謝遺伝子のインスリン応答性転写制御機構の解析2009
- Author(s)
  廣田恵子
- Organizer
  日本生化学会関東支部例会「若手が担う次世代型生化学研究」
- Place of Presentation
  つくば国際会議場(茨城県)
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] 糖代謝遺伝子のインスリン応答性転写制御機構の解析2009
- Author(s)
  廣田恵子, 石田純治, 坂巻純一, 深水昭吉
- Organizer
  日本生化学会関東支部例会「若手が担う次世代型生化学研究」
- Place of Presentation
  茨城
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] HMGA1によるFoxo1を介したG6Pase遺伝子発現調節機構の解明2009
- Author(s)
  堺井陽香里,廣田恵子, 大徳浩照,深水昭吉
- Organizer
  遺伝情報 DECODE・冬のワークショップ
- Place of Presentation
  新潟
- Year and Date
  2009-01-19
- Data Source
  KAKENHI-PROJECT-19780247
[Presentation] HMGA1による転写因子Foxo1を介したG6Pase遺伝子発現制御機構の解明2009
- Author(s)
  堺井陽香里, 廣田恵子, 大徳浩照, 深水昭吉
- Organizer
  日本生化学会関東支部例会「若手が担う次世代型生化学研究」
- Place of Presentation
  茨城
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21780307
[Presentation] 糖代謝遺伝子のインスリン応答性転写制御機構の解析2009
- Author(s)
  廣田恵子
- Organizer
  (社)日本生化学会関東支部例会「若手が担う次世代型生化学研究」
- Place of Presentation
  つくば
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] HNF4・FOXO1における絶食・摂食に応答した糖代謝遺伝子発現制御機構の解析2009
- Author(s)
  廣田恵子、深水昭吉
- Organizer
  第1回核内受容体研究会
- Place of Presentation
  東京
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19780247
[Presentation] 絶食・摂食応答性遺伝子発現制御におけるHNF4・FOXO1の機能解明2009
- Author(s)
  廣田恵子
- Organizer
  第13回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  大宮
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] HNF4・FOXO1における絶食・摂食に応答した糖代謝遺伝子発現制御機構の解析2009
- Author(s)
  廣田恵子
- Organizer
  第1回核内受容体研究会
- Place of Presentation
  東京
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] 転写因子HNF4・FOXOIによる糖新生・解糖系律速酵素の転写制御機構の解析2008
- Author(s)
  廣田恵子
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] A combination of HNF-4 Foxo1 is Required for Reciprocal Transcriptional Regulation of Glucokinase and Glucose-6-phosphatase Genes in Response to fasting and feeding2008
- Author(s)
  廣田恵子、石田純治、島本陽子、西原茂城、児玉典央、太田和秀、山本雅之、谷本啓司、深水昭吉
- Organizer
  THE 21^<st> NAITO CONERENCE
- Place of Presentation
  山梨
- Year and Date
  2008-06-24
- Data Source
  KAKENHI-PROJECT-19780247
[Presentation] 転写因子HNF4・FOXO1による糖新生・解糖系律速酵素の転写制御機構の解析2008
- Author(s)
  廣田恵子、石田純治、坂巻純一、島本陽子、西原茂城、児玉典央、太田和秀、山本雅之、谷本啓司、深水昭吉
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19780247
[Presentation] A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding2008
- Author(s)
  廣田恵子、石田純治、山本雅之、谷本啓司、深水昭吉
- Organizer
  New Frontier for Lipid and Energy Metabolism
- Place of Presentation
  茨城
- Year and Date
  2008-02-18
- Data Source
  KAKENHI-PROJECT-19780247
[Presentation] Caenorhabditis elegansにおける転写因子DAF-16のアルギニンメチル化酵素による制御機構の解明2008
- Author(s)
  高橋悠太・大徳浩照・山形一行・廣田恵子・石井直明・深水昭吉
- Organizer
  08'遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  越後湯沢
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] In vivo LUC assayを用いた糖代謝制御遺伝子発現調節機構の解析2007
- Author(s)
  廣田恵子・石田純治・深水昭吉
- Organizer
  第24回日本疾患モデル学会
- Place of Presentation
  つくば
- Year and Date
  2007-09-01
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] In vivo LUC assayを用いた糖代謝制御遺伝子発現調節機構の解析2007
- Author(s)
  廣田恵子、石田純治、深水昭吉
- Organizer
  第24回日本疾患モデル学会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2007-08-31
- Data Source
  KAKENHI-PROJECT-19780247
[Presentation] Dietary methionine restriction in axenic medium decreases both methionine and S-adenosyl-L-methionine levels.
- Author(s)
  Yamauchi, R., Hirota, K., Xu, Z., Iizuka, K., Daitoku, H., Kako, K., Fukamizu, A.
- Organizer
  6th Asia-pacific C.elegans Meeting
- Place of Presentation
  奈良県、奈良春日野国際フォーラム
- Year and Date
  2014-07-15 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-26450119
[Presentation] ヒスチジンNt-メチル基転移酵素の探索
- Author(s)
  狩野明彦，加香孝一郎，廣田恵子，深水昭吉
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] SAM代謝とメチル基転移酵素
- Author(s)
  深水昭吉，廣田恵子，大徳浩照，加香孝一郎
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PLANNED-23116004

1. FUKAMIZU Akiyoshi (60199172)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
2. DAITOKU Hiroaki (30361314)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. KAKO Koichiro (60311594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. TAKAHASHI Hidekazu (90450402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 松岡雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirota Keiko 廣田 恵子

HIROTA Keiko 廣田 恵子

Research Projects

Research Products

Co-Researchers

線虫C. elegansにおける排泄リズムの制御と消化・寿命への影響Principal Investigator

Principal Investigator

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Review Section

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Functional roles of initiator methionine tRNAPrincipal Investigator

Principal Investigator

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Analysis of short-term starvation-induced longevity via methionine metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

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Crosstalk of transcriptional status and amino acid metabolism

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

The role of HMGA1 for the G6Pase gene transcriptionPrincipal Investigator

Principal Investigator

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Research Institution

Analysis for HNF-4-mediated transcriptional regulation in response to insulin stimulation in the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Elucidation of DECODE cycle that regulates homeostasis mediated by protein modification.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 遺伝子制御の新たな主役 栄養シグナル2016

Author(s)

Publisher

Data Source

[Journal Article] SAMS-1 is required for the normal defecation motor program in Caenorhabditis elegans.2024

Author(s)

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Data Source

[Journal Article] N-acetylcysteine restores the cadmium toxicity of Caenorhabditis elegans2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans.2017

Author(s)

Hirota Keiko 廣田恵子

HIROTA Keiko 廣田恵子

[Book] 遺伝子制御の新たな主役栄養シグナル2016