Mizutani Taketoshi 水谷壮利

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MIZUTANI Taketoshi 水谷壮利

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Researcher Number	00376617
Other IDs	https://orcid.org/0000-0002-1329-6512
Affiliation (Current)	2024: 国立感染症研究所, 感染症危機管理研究センター, 主任研究官
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京大学, 大学院新領域創成科学研究科, 特任准教授 2016: 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員 2013 – 2015: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2007 – 2011: The University of Tokyo, 医科学研究所, 助教 2004 – 2006: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Virology / Basic Section 59040:Nutrition science and health science-related / Tumor therapeutics / Biological Sciences Except Principal Investigator Biological Sciences / Virology / Carcinogenesis
Keywords	Principal Investigator poliovirus / ドラッグデリバリー / 血液脳関門 / SNF / SWI / レトロウイルス / HIV-1 / microbiota / dysbiosis / SARS-CoV-2 … More / microbiome / COVID-19 / 血管内皮細胞 / cell penetrating peptide / drug derivery system / Blood Brain Barrier / Blood brain barrier / DDS / ポリオウイルス / NF-kappaB / SWI/SNF / NF-κB / SWI/SNF複合体 / SNF複合体 … More Except Principal Investigator SWI / siRNA / MLV / HIV / エピジェネティクス / レンチウイルス / レトロウイルス / SNF複合体 / miRNA / Brm / ジーンサイレンシング / クロマチン構造変換因子 / Brm遺伝子 / レトロウイルスベクター / 遺伝子治療 / latent infection / reactivation / gene silencing / splicing / SNF complex / epigenetics / 後転写制御 / ヒストンメチル化 / プロテオミクス / 転写後制御 / RNA編集 / p54nrb / 潜伏感染 / 再活性化 / ジンサイレンシング / スプライシング / Egr1 / CD44 / Cdx2 / がん細胞 / フィードバックループ / SWI/SNF複合体 / miR200c / 上皮-間充織変換 / miR-15/-16 / miR-199a / miR-200c / Cdx1 / 上皮‐間充織変換 / 発現制御 / GFP遺伝子 / ウイルスベクター / NFI-B / miR-21 / shRNA / in situ hybridization / feedback 制御 / 大腸癌 / RNA干渉 / NF-I / プロモーター / microRNA / レンチウイルスベクター / Decoy RNA / Requiem / AP-1 / NFkB / SNFクロマチン構造変換因子 / NFkappaB / 足場非依存的な増殖 / requiem / RelB / patched遺伝子 / 再生治療 / ジーンサイレンシンク / ヒストンアセチル化 / 癌抑制遺伝子 / 再生医療 Less

Analysis of the mechanism of exacerbation of SARS-CoV2 infection by lifestyle-related diseasesPrincipal Investigator
- Principal Investigator
  
  水谷壮利
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
Improvment of drug delivery system (DDS) targeting the central nerve systemPrincipal Investigator
- Principal Investigator
  
  MIZUTANI Taketoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Microbial Chemistry Research Foundation
The identification of host molecules in PV transmission into brood brain barrierPrincipal Investigator
- Principal Investigator
  
  MIZUTANI Taketoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Virology
- Research Institution
  Microbial Chemistry Research Foundation
Significance and Molecular mechanisms of abnormal expression of miRNA in carcinogenesis.
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  The University of Tokyo
Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.Principal Investigator
- Principal Investigator
  
  MIZUTANI Taketoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
発現多様性を産み出すゲノム動態を介したHIV-1発現制御機構の解析Principal Investigator
- Principal Investigator
  
  水谷壮利
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of new types of retrovirus vectors that modulate epigenetical regulation.
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of host-retrovirus interaction by analyzing chromatin dynamics
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
癌抑制遺伝子を長期間高レベルで発現する新規レトロウイルスベクターとその産生系
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

[Journal Article] Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV2024
- Author(s)
  Ishizaka Aya、Koga Michiko、Mizutani Taketoshi、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Adachi Eisuke、Suzuki Yutaka、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
- Journal Title
  
  BMC Microbiology
  
  Volume: 24 Issue: 1 Pages: 6-6
- DOI
  10.1186/s12866-023-03157-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20926, KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592
[Journal Article] Antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccination2023
- Author(s)
  Ishizaka Aya、Koga Michiko、Mizutani Taketoshi、Uraki Ryuta、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Yamamoto Shinya、Imai Masaki、Tsutsumi Takeya、Suzuki Yutaka、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
- Journal Title
  
  Virology Journal
  
  Volume: 20 Issue: 1 Pages: 146-146
- DOI
  10.1186/s12985-023-02113-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20926, KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592
[Journal Article] Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization2022
- Author(s)
  Mizutani Taketoshi、Ishizaka Aya、Koga Michiko、Ikeuchi Kazuhiko、Saito Makoto、Adachi Eisuke、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Yasuhara Atsuhiro、Kiyono Hiroshi、Matano Tetsuro、Suzuki Yutaka、Tsutsumi Takeya、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 10 Issue: 2 Pages: 1-13
- DOI
  10.1128/spectrum.01689-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592, KAKENHI-PROJECT-18H05280
[Journal Article] Role of Microbiota in Viral Infections and Pathological Progression2022
- Author(s)
  Mizutani T, Ishizaka A, Koga M, Tsutsumi T, Yotsuyanagi H
- Journal Title
  
  Viruses
  
  Volume: in press Issue: 5 Pages: 950-950
- DOI
  10.3390/v14050950
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07901, KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592
[Journal Article] Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.2016
- Author(s)
  Mizutani T, Ishizaka A, Nihei C.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 6 Pages: 2829-2836
- DOI
  10.1074/jbc.m115.690941
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14413, KAKENHI-PROJECT-26670204, KAKENHI-PROJECT-15K19117
[Journal Article] Double PHD finger proteins DPF3a and 3b are reouired as transcriptional coactivators in the SWI/SNF complex-dependent activation of the NF-κB Re1A/p50 heterodimer2012
- Author(s)
  Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: (印刷中) Issue: 15 Pages: 11924-11933
- DOI
  10.1074/jbc.m111.322792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09328, KAKENHI-PROJECT-21590507, KAKENHI-PUBLICLY-22115511, KAKENHI-PROJECT-22300318, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24115715, KAKENHI-PUBLICLY-24117704
[Journal Article] Double Plant Homeodomain (PHD) Finger Proteins DPF3a and -3b Are Required as Transcriptional Co-activators in SWI/SNF Complex-dependent Activation of NF-κB RelA/p50 Heterodimer2012
- Author(s)
  Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 287(15) Pages: 11924-11933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590507
[Journal Article] Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF- RelA/p50 heterodimer.2012
- Author(s)
  Ishizaka, A., Mizutani, T., Kobayashi, K., Tando, T., Sakurai, K., Fujiwara, T., and Iba, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 11924-11933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF_KB pathway.2010
- Author(s)
  Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iids, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J., Iba, H.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 21951-21960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF-〓B pathway.2010
- Author(s)
  ando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J and Iba H.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 29 Pages: 21951-60
- DOI
  10.1074/jbc.m109.087783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390148, KAKENHI-PROJECT-21590507, KAKENHI-PROJECT-22659094
[Journal Article] Requiem protein links ReIB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.2010
- Author(s)
  Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285(29) Pages: 21951-21960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590507
[Journal Article] Requiem protein links RelB/p52 and theBrm-type SWI/SNF complex in a non-canonical NFκB pathway.2010
- Author(s)
  Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iida, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J., and Iba, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 21951-21960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Loss of the Brm-Type SWI/SNF Chromatin Remodeling Complex Is a Strong Barrier to the Tat-Independent Transcriptional Elongation of Human Immunodeficiency Virus Type 1 Transcripts2009
- Author(s)
  Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H
- Journal Title
  
  JOURNAL OF VIROLOGY 83
  
  Pages: 11569-11580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590507
[Journal Article] LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development.2009
- Author(s)
  Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H.
- Journal Title
  
  Clin. Cancer Res. 15
  
  Pages: 4009-4016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regurate villin expression in gastrointestinal cells2009
- Author(s)
  Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura. R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H.
- Journal Title
  
  Experimental cell Reseach (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041020
[Journal Article] Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of HIV-1 transcripts2009
- Author(s)
  Mizutani, T., Ishizaka, A., Tomizawa, M., Okazaki, T., Yamamichi, N., Kawana-Tachikawa, A., Iwamoto, A., Iba, H.
- Journal Title
  
  Journal of Virology 83
  
  Pages: 11569-11580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells2009
- Author(s)
  Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T., Ishizaka, A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Omata, M., Iab, H.
- Journal Title
  
  Experimental Cell Research 315
  
  Pages: 1779-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.2009
- Author(s)
  Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H.
- Journal Title
  
  Exp. Cell Res. 315
  
  Pages: 1779-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development2009
- Author(s)
  Yamamichi, N., Shimomura, R., Inada, K., Sakurai, K., Haraguchi, T., Ozaki, Y., Fujita, S., Mizutani, T., Furukawa, C., Fujishiro, M., Ichinose, M., Shiogama, K., Tsutsumi, Y., Omata, M., Iba, H
- Journal Title
  
  Clinical Cancer Research 15
  
  Pages: 4009-4016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of HIV-1 transcripts.2009
- Author(s)
  Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H.
- Journal Title
  
  J of Virol. 83
  
  Pages: 11569-11580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and Ikappa Bzeta.2008
- Author(s)
  Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K.
- Journal Title
  
  J Biol Chem. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041020
[Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts inconcert with p54^<nrb>.2008
- Author(s)
  Ito, T., Watanabe, H., Yamamichi, N., Kondo, S., Tando, T., Haraguchi, T., Mizutani, T., Sakurai, K., Fujita, S., Izumi, T., Isobe, T., and Iba, H.
- Journal Title
  
  Biochemical J. 411
  
  Pages: 201-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism.2008
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H.
- Journal Title
  
  J Mol Biol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041020
[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008
- Author(s)
  Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamamichi, N., Sakurai, K. and Iba, H.
- Journal Title
  
  J. Mol. Biol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts inconcert with p54(nrb).2008
- Author(s)
  Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba H.
- Journal Title
  
  Biochem J. 411(1)
  
  Pages: 201-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041020
[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba, H.
- Journal Title
  
  J. Mol. Biol 378
  
  Pages: 492-504
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism2008
- Author(s)
  Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamarnichi, N., Sakurai, K., and Iba, H.
- Journal Title
  
  J.Mol.Biol. 378
  
  Pages: 492-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and IκBζ.2008
- Author(s)
  Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H., Matsumoto M, Honda, K, Smale ST, Takeda, K.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 12468-12477
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54^<nrb>2008
- Author(s)
  Ito, T., Watanabe, H., Yamamichi, N., Kondo, S. , Tando, T. ,H araguchi, T., Mizutani, T., Sakurai, K., Fujita, S., Izumi, T., Isobe, T., and Iba, H.
- Journal Title
  
  Biochemical J. 411
  
  Pages: 201-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and IκBζ2008
- Author(s)
  Kayama, H., Ramirez-Carrozzi, V.R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S.T., and Takeda, K.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 12468-12477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and lκBζ.2008
- Author(s)
  Kayama, H., Ramirez-Carrozzi, V. R, Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S.T., and Takeda, K.
- Journal Title
  
  J. Biol. Chem. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54nrb2008
- Author(s)
  Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba H.
- Journal Title
  
  Biochemical J. 411
  
  Pages: 201-209
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state.2007
- Author(s)
  Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe H, Shiogama K, Fujishiro M, Okazaki T, Yahagi N, Haraguchi T, Fujita S, Tsutsumi Y, Omata M, Iba H.
- Journal Title
  
  Cancer. Res. 67(22)
  
  Pages: 10727-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041020
[Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007
- Author(s)
  Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba H.
- Journal Title
  
  FEBS Lett. 581(25)
  
  Pages: 4949-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041020
[Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histological features and differentiation state.2007
- Author(s)
  Yamamichi, N., Inada, K., Ichinose, M., Yamamichi-Nishina, M., Mizutani, T., Watanabe, H., Shiogama, K., Okazaki, T., Fujishiro, M., Yahagi, N., Haraguchi T., Fujita, S., Tsutsumi, Y., Omata, M. and Iba, H.
- Journal Title
  
  Cancer Research 22
  
  Pages: 10727-10735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007
- Author(s)
  Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba, H.
- Journal Title
  
  FEBS Letter 581
  
  Pages: 4949-4954
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] RNA-dependent transcriptional silencing does not contribute to retroviral gene silencing in human cells.2007
- Author(s)
  Haraguchi, T., Mizutani, T., Yamamichi, N., Ito, T., Minoguchi, S., and Iba, H.
- Journal Title
  
  FEBS Letter 581
  
  Pages: 4949-4954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] A protein associated with Toll-like Receptor 4 (PRAT4A) regulates cell surface expression of TLR4.2006
- Author(s)
  Wakabayashi Y, Kobayashi M, Akashi-Takamura S, Tanimura N, Konno K, Takahashi K, Ishii T, Mizutani T, Iba, H, Kouro T, Takaki S, Takatsu K., Oda, Y., Ishihama, Y., Saitoh, S -I., Miyake, K.
- Journal Title
  
  J. Immunol 177
  
  Pages: 1772-1779
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines.2006
- Author(s)
  Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, Iba H.
- Journal Title
  
  Oncogene 25
  
  Pages: 470-479
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits anti-oncogenic potential.2005
- Author(s)
  Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose M, Omata M, Iba, H.
- Journal Title
  
  Oncogene 24
  
  Pages: 5471-5481
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NFκB pathway.
- Author(s)
  Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H.
- Journal Title
  
  J Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article]
- Author(s)
  Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe, H., Shiogama K, Okazaki T, Fujishiro M, Yahagi N
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Ccbc2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells
- Author(s)
  Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T. , Ishizaka , A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Ornata, M., and Iba, H.
- Journal Title
  
  Exp. Cell Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Patent] 血液脳関門を透過する薬物輸送体、ペプチド及びその用途2017
- Inventor(s)
  水谷壮利、石坂彩
- Industrial Property Rights Holder
  公益財団法人微生物化学研究会
- Industrial Property Rights Type
  特許
- Filing Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K14413
[Presentation] SARS-CoV-2感染がPLWHに及ぼす腸内細菌叢変化と病態との相関関係2023
- Author(s)
  水谷壮利, 石坂彩, 古賀道子, 山吉誠也, 岩附研子, 安達英輔, 鈴木穣, 河岡義裕, 四柳宏
- Organizer
  日本エイズ学会
- Data Source
  KAKENHI-PROJECT-21K11592
[Presentation] SARS-CoV-2罹患による腸内細菌叢と炎症惹起の動態解析2021
- Author(s)
  水谷壮利、古賀道子、石坂彩、山吉誠也、岩附　研子、安原　敦洋、池内和彦、齋藤　真、安達英輔、堤武也、清野宏、俣野哲朗、河岡義裕、四柳宏
- Organizer
  第35回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-21K11592
[Presentation] HIV-1 promoter is negatively regulated by hnRNPA1 in Tat independent mannor.2011
- Author(s)
  Mizutani, T., Ishizaka, A., and Iba, H.
- Organizer
  日本ウイルス学会学術集会(IUMS Sapporo)
- Place of Presentation
  札幌
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] HIV-のTat非依存的な発現におけるSWI/SNF複合体の作用点の解析2010
- Author(s)
  水谷壮利、石坂彩、伊庭英夫
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県あわぎんホール
- Data Source
  KAKENHI-PROJECT-21590507
[Presentation] Analysis for the regulation of transcriptional elongation of HIV-1 transcript by proyiral non-coding RNA2010
- Author(s)
  Mizutani T, Ishizaka A, Iba H
- Organizer
  The 10^<th> Awajishima International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路島夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-21590507
[Presentation] Analysis for the regulation of transcriptional elongation of HIV-1 transcript by proviral non-coding RNA2010
- Author(s)
  Mizutani T, Ishizaka A, and Iba H
- Organizer
  The 10th Awajishima International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路島夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-21590507
[Presentation] HIVのTat非依存的な発現におけるSWI/SNF複合体の作用点の解析2009
- Author(s)
  水谷壮利、石坂彩、富沢麻利子、立川(川名)愛、岩本愛吉、伊庭英夫
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京都都市センターホテル
- Data Source
  KAKENHI-PROJECT-21590507
[Presentation] HIV-1 Tat非依存的な発現におけるSWI/SNF複合体の作用点の解析2009
- Author(s)
  水谷壮利
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] The Brm-type SWI/SNF chromatin remodeling complex plays an important role in transcriptional elongation of HIV-1 in the absence of Tat.2009
- Author(s)
  Ishizaka A, Mizutani T, Tomizawa M, Kawana-Tachikawa A, Iwamoto A, Iba H
- Organizer
  The 9^<th> Awajishima International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路島夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-21590507
[Presentation] Requiem functions in a non-canonical NFκB pathway as a linker protein between Rel/p52 and the SWI/SNF complex2009
- Author(s)
  丹藤利夫、石坂彩、原口健、水谷壮利、秋山泰身、井上純一郎、伊庭英夫
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] The Brin-type SWI/SNF chromatin remodeling complex plays an important role in transcriptional elongation of HIV-1 in the absence of Tat2009
- Author(s)
  Ishizaka, A., Mizutani, T., Tomizawa, M., Kawana-Tachikawa, A., Iwamoto, A., Iba, H.
- Organizer
  The 9^<th> Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路島
- Year and Date
  2009-09-08
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] The Brm-type SWI/SNF chromatin remodeling complex plays an important role in transcriptional elongation of HIV-1 in the absence of Tat2009
- Author(s)
  Ishizaka, A., Mizutani, T., Tomizawa, M., Kawana-Tachikawa, A., Iwamoto, A., Iba, H.
- Organizer
  The 9thAwaji International Forum on Infection and Immunity
- Place of Presentation
  淡路島
- Year and Date
  2009-09-08
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Requiem functions in anon-canonical NFκB pathway as a linker protein between Rel/p52 and the SWI/SNF complex2009
- Author(s)
  丹藤利夫、石坂彩、原口健、水谷壮利、秋山泰身、井上純一郎、伊庭英夫
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Brm, a catalytic subunit of SVI/SNF complex is required for Tat-independent stable expression of HIV-12008
- Author(s)
  水谷壮利、石坂彩、山道信毅、伊庭英夫
- Organizer
  The 8^<th> Awaiishima International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路島夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-19041020
[Presentation] HIV-1のTat非依存的な発現を維持するSWI/SNF複合体の作用機序の解析2008
- Author(s)
  石坂彩、水谷壮利、山道信毅、原口健、富沢麻利子、岩本愛吉、伊庭英夫
- Organizer
  第5回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Brm, a catalytic subunit of the SWI/SNF complex is required for Tat-independent stable expression of HIV-12008
- Author(s)
  Mizutani, T., Ishizaka, A., Tomizawa, M., Yamamichi, N., Tando, T., Iwamoto, A., and Iba, H.
- Organizer
  China-Japan ajoint Workshop on New-Generation Vaccines for Infectious Diseases
- Place of Presentation
  北京
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] miRNAが形成する制御ネットワークとがん2008
- Author(s)
  伊庭英夫、藤田修二、山道信毅、櫻井浩平、水谷壮利
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] HIV-1のTat非依存的な発現を維持するSWI/SNF複合体の作用点の解析2008
- Author(s)
  石坂彩、水谷壮利、山道信毅、原口健、富沢麻利子、岩本愛吉、伊庭英夫
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19041020
[Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism Systems Biology2007
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Iba H.
- Organizer
  Global Regulation of Gene Expression
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Brm, a catalytic subunit of SWI/SNF complex is required for Tat-independent stable expression of HIV-12007
- Author(s)
  水谷壮利、石坂彩、山道信毅、伊庭英夫
- Organizer
  The 7th Awajishima International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路島夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-19041020
[Presentation] High expression of miR-21 was detected in colorectal carcinoma but not in adenoma by LNA-based in situhybridization2007
- Author(s)
  山道信毅、下村龍一、水谷壮利、稲田健一、藤田修二、櫻井浩平、一瀬雅夫、堤寛、小俣政男、伊庭英夫
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] HIV-1のTat非依存的な発現におけるSWI/SNF複合体の機能解析2007
- Author(s)
  水谷壮利、石坂彩、山道信毅、原口健、伊庭英夫
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Brm, a catalytic subunit of the SWI/SNF complex is required for Tat-independent stable expression of HIV-12007
- Author(s)
  Mizutani T, Ishizaka A, Yamamichi N, Okazaki T, Iba H.
- Organizer
  第7回淡路島感染・免疫フォーラム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] レトロウイルス遺伝子発現の不安定性の解析2007
- Author(s)
  岡崎拓矢、山道信毅、水谷壮利、石坂彩、古川千尋、伊庭英夫
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] AP-1 triggers the sustained transcription of miR-21 through an evolutionarily conserved feedback mechanism2007
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H.
- Organizer
  The 11th German-Japanese Cancer Workshop
- Place of Presentation
  京都
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] HIV-1のTat非依存的な発現におけるSWI/SNF複合体の機能解析2007
- Author(s)
  水谷壮利、石坂彩、山道信毅、伊庭英夫
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19041020
[Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism2007
- Author(s)
  Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamanichi, N., Iba, H.
- Organizer
  Systems Biology: Global Regulation of Gene Expression 2007 April
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] 胃癌におけるクロマチン構造変換因子SWI/SNF複合体の触媒サブユニットBrm欠失:癌化におけるBrm欠失の役割2006
- Author(s)
  山道信毅、稲田健一、渡部博貴、山道(仁科)光恵、水谷壮利、矢作直久、一瀬雅夫、堤寛、小俣政男、伊庭英夫
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] SWI/SNF複合体の触媒サブユニットBrmはTERT遺伝子の転写と選択的スプライシングに関与する2006
- Author(s)
  伊藤太二、渡部博貴、山道信毅、近藤俊輔、板垣千春、丹藤利夫、水谷壮利、原口健、櫻井浩平、藤田修二、泉友則、礒辺俊明、伊庭英夫
- Organizer
  日本分子生物学会2006フォーラム(分子生物学の未来)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] レトロウイルスプロモーターサイレンシングにおけるRNAi機構の役割の検証2006
- Author(s)
  原口健、水谷壮利、伊庭英夫
- Organizer
  第54回日本ウイルス学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] クロマチン構造変換因子SWI/SNF複合体のHIV-1発現維持機構の機能解析2006
- Author(s)
  水谷壮利、石坂彩、山道信毅、岡崎拓矢、伊庭英夫
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] 多くのヒト癌で高レベルに発現するmir-21遺伝子のプロモーター解析とmir-21の標的遺伝子の同定2006
- Author(s)
  伊庭英夫、藤田修二、伊藤太二、水谷壮利
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] ヒト癌細胞株で転写後抑制を受けているSWI/SNF複合体の触媒サブユニットBrmは、HDAC阻害剤により発現誘導され抗癌活性を示す2005
- Author(s)
  山道信毅、水谷壮利、渡部博貴、伊藤太二、矢作直久、一瀬雅夫、小俣政男、伊庭英夫
- Organizer
  第64回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] ES細胞に感染したレトロウイルスに見られるDNAメチル化に依存した可逆的ジーンサイレンシング2005
- Author(s)
  箕口滋、渡部博貴、水谷壮利、伊庭英夫
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] BrmとBRG1の発現を共に欠失するヒト非小細胞肺がん細胞株における神経特異的遺伝子群の発現誘導とその機構2005
- Author(s)
  渡部博貴、水谷壮利、山道信毅、伊庭英夫
- Organizer
  第64回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Unique expression mechanisms of Brm protein, a key regulatory host factor for continuous retroviral expression2005
- Author(s)
  Yamamichi N, Mizutani T, Yamamichi-Nishina M, Haraguchi T, Kameda T, Iba H.
- Organizer
  第5回あわじしま感染症・免疫フォーラム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] レトロウイルスの発現維持に必須な宿主因子Brmの特異な生合成過程2005
- Author(s)
  伊庭英夫、山道信毅、水谷壮利、原口健
- Organizer
  第53回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2005-11-22
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] p54nrbとSWI/SNF複合体の相互作用とその生化学的意義2005
- Author(s)
  伊藤太二、渡部博貴、山道信毅、近藤俊輔、板垣千春、丹藤利夫、水谷壮利、原口健、藤田修二、泉友則、礒辺俊明、伊庭英夫
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Reversible switching of MSCV Proviral Expression Reflects Dynamics of DNA Methylation in Embryonic Stem Cells2005
- Author(s)
  箕口滋、渡部博貴、水谷壮利、伊庭英夫
- Organizer
  文部科学省特定領域研究「幹細胞の可塑性と未分化性維持機構」国際シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-17016015

1. IBA Hideo (60111449)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MINOGUCHI Shigeru (60322757)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. ITO Taiji (60343109)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
4. HARAGUCHI Takeshi (10549455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
5. YAMAMICHI Nobutake (30463897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 35 results
6. KOHARA Michinori (10250218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. INADA Kenichi (70246081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISOBE Yoshiaki (70106607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KIYAMA Noubuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 伊庭英生

# of Collaborated Projects: 0 results

# of Collaborated Products: 70 results
11. 古賀道子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石坂彩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 秋山泰身

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 井上純一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 堤武也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizutani Taketoshi 水谷 壮利

MIZUTANI Taketoshi 水谷 壮利

Research Projects

Research Products

Co-Researchers

Analysis of the mechanism of exacerbation of SARS-CoV2 infection by lifestyle-related diseasesPrincipal Investigator

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Improvment of drug delivery system (DDS) targeting the central nerve systemPrincipal Investigator

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The identification of host molecules in PV transmission into brood brain barrierPrincipal Investigator

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Significance and Molecular mechanisms of abnormal expression of miRNA in carcinogenesis.

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Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.Principal Investigator

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発現多様性を産み出すゲノム動態を介したHIV-1発現制御機構の解析Principal Investigator

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Development of new types of retrovirus vectors that modulate epigenetical regulation.

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Elucidation of host-retrovirus interaction by analyzing chromatin dynamics

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癌抑制遺伝子を長期間高レベルで発現する新規レトロウイルスベクターとその産生系

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[Journal Article] Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV2024

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[Journal Article] Antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccination2023

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[Journal Article] Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization2022

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[Journal Article] Role of Microbiota in Viral Infections and Pathological Progression2022

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Journal Title

DOI

Data Source

[Journal Article] Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.2016

Mizutani Taketoshi 水谷壮利

MIZUTANI Taketoshi 水谷壮利