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Mizutani Taketoshi  水谷 壮利

… Alternative Names

水谷 壮利  ミズタニ タケトシ

MIZUTANI Taketoshi  水谷 壮利

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Researcher Number 00376617
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1329-6512
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立感染症研究所 感染症危機管理研究センター, 主任研究員
Affiliation (based on the past Project Information) *help 2025: 国立感染症研究所, 感染症危機管理研究センター, 主任研究官
2021 – 2023: 東京大学, 大学院新領域創成科学研究科, 特任准教授
2016: 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員
2013 – 2015: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員
2007 – 2011: The University of Tokyo, 医科学研究所, 助教
2004 – 2006: 東京大学, 医科学研究所, 助手
Review Section/Research Field
Principal Investigator
Virology / Basic Section 90120:Biomaterials-related / Basic Section 59040:Nutrition science and health science-related / Tumor therapeutics / Biological Sciences
Except Principal Investigator
Biological Sciences / Virology / Carcinogenesis
Keywords
Principal Investigator
poliovirus / ドラッグデリバリー / 血液脳関門 / SNF / SWI / レトロウイルス / HIV-1 / microbiota / dysbiosis / SARS-CoV-2 … More / microbiome / COVID-19 / 血管内皮細胞 / cell penetrating peptide / drug derivery system / Blood Brain Barrier / Blood brain barrier / DDS / ポリオウイルス / NF-kappaB / SWI/SNF / NF-κB / SWI/SNF複合体 / SNF複合体 … More
Except Principal Investigator
SWI / siRNA / MLV / HIV / エピジェネティクス / レンチウイルス / レトロウイルス / SNF複合体 / miRNA / Brm / ジーンサイレンシング / クロマチン構造変換因子 / Brm遺伝子 / レトロウイルスベクター / 遺伝子治療 / latent infection / reactivation / gene silencing / splicing / SNF complex / epigenetics / 後転写制御 / ヒストンメチル化 / プロテオミクス / 転写後制御 / RNA編集 / p54nrb / 潜伏感染 / 再活性化 / ジンサイレンシング / スプライシング / Egr1 / CD44 / Cdx2 / がん細胞 / フィードバックループ / SWI/SNF複合体 / miR200c / 上皮-間充織変換 / miR-15/-16 / miR-199a / miR-200c / Cdx1 / 上皮‐間充織変換 / 発現制御 / GFP遺伝子 / ウイルスベクター / NFI-B / miR-21 / shRNA / in situ hybridization / feedback 制御 / 大腸癌 / RNA干渉 / NF-I / プロモーター / microRNA / レンチウイルスベクター / Decoy RNA / Requiem / AP-1 / NFkB / SNFクロマチン構造変換因子 / NFkappaB / 足場非依存的な増殖 / requiem / RelB / patched遺伝子 / 再生治療 / ジーンサイレンシンク / ヒストンアセチル化 / 癌抑制遺伝子 / 再生医療 Less
  • Research Projects

    (10 results)
  • Research Products

    (83 results)
  • Co-Researchers

    (15 People)
  •  標的特異性を付与した細菌由来の細胞外小胞ベクターの基盤開発Principal Investigator

    • Principal Investigator
      水谷 壮利
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      National Institute of Infectious Diseases
  •  Analysis of the mechanism of exacerbation of SARS-CoV2 infection by lifestyle-related diseasesPrincipal Investigator

    • Principal Investigator
      水谷 壮利
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      The University of Tokyo
  •  Improvment of drug delivery system (DDS) targeting the central nerve systemPrincipal Investigator

    • Principal Investigator
      MIZUTANI Taketoshi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      Microbial Chemistry Research Foundation
  •  The identification of host molecules in PV transmission into brood brain barrierPrincipal Investigator

    • Principal Investigator
      MIZUTANI Taketoshi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Virology
    • Research Institution
      Microbial Chemistry Research Foundation
  •  Significance and Molecular mechanisms of abnormal expression of miRNA in carcinogenesis.

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Carcinogenesis
    • Research Institution
      The University of Tokyo
  •  Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.Principal Investigator

    • Principal Investigator
      MIZUTANI Taketoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      The University of Tokyo
  •  発現多様性を産み出すゲノム動態を介したHIV-1発現制御機構の解析Principal Investigator

    • Principal Investigator
      水谷 壮利
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of new types of retrovirus vectors that modulate epigenetical regulation.

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Elucidation of host-retrovirus interaction by analyzing chromatin dynamics

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Virology
    • Research Institution
      The University of Tokyo
  •  癌抑制遺伝子を長期間高レベルで発現する新規レトロウイルスベクターとその産生系

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

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All Journal Article Presentation Patent

  • [Journal Article] Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV2024

    • Author(s)
      Ishizaka Aya、Koga Michiko、Mizutani Taketoshi、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Adachi Eisuke、Suzuki Yutaka、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
    • Journal Title

      BMC Microbiology

      Volume: 24 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s12866-023-03157-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K20926, KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592
  • [Journal Article] Antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccination2023

    • Author(s)
      Ishizaka Aya、Koga Michiko、Mizutani Taketoshi、Uraki Ryuta、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Yamamoto Shinya、Imai Masaki、Tsutsumi Takeya、Suzuki Yutaka、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
    • Journal Title

      Virology Journal

      Volume: 20 Issue: 1 Pages: 146-146

    • DOI

      10.1186/s12985-023-02113-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K20926, KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592
  • [Journal Article] Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization2022

    • Author(s)
      Mizutani Taketoshi、Ishizaka Aya、Koga Michiko、Ikeuchi Kazuhiko、Saito Makoto、Adachi Eisuke、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Yasuhara Atsuhiro、Kiyono Hiroshi、Matano Tetsuro、Suzuki Yutaka、Tsutsumi Takeya、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
    • Journal Title

      Microbiology Spectrum

      Volume: 10 Issue: 2 Pages: 1-13

    • DOI

      10.1128/spectrum.01689-21

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592, KAKENHI-PROJECT-18H05280
  • [Journal Article] Role of Microbiota in Viral Infections and Pathological Progression2022

    • Author(s)
      Mizutani T, Ishizaka A, Koga M, Tsutsumi T, Yotsuyanagi H
    • Journal Title

      Viruses

      Volume: in press Issue: 5 Pages: 950-950

    • DOI

      10.3390/v14050950

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07901, KAKENHI-PROJECT-21K07314, KAKENHI-PROJECT-21K11592
  • [Journal Article] Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.2016

    • Author(s)
      Mizutani T, Ishizaka A, Nihei C.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 6 Pages: 2829-2836

    • DOI

      10.1074/jbc.m115.690941

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14413, KAKENHI-PROJECT-26670204, KAKENHI-PROJECT-15K19117
  • [Journal Article] Double PHD finger proteins DPF3a and 3b are reouired as transcriptional coactivators in the SWI/SNF complex-dependent activation of the NF-κB Re1A/p50 heterodimer2012

    • Author(s)
      Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H
    • Journal Title

      The Journal of Biological Chemistry

      Volume: (印刷中) Issue: 15 Pages: 11924-11933

    • DOI

      10.1074/jbc.m111.322792

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J09328, KAKENHI-PROJECT-21590507, KAKENHI-PUBLICLY-22115511, KAKENHI-PROJECT-22300318, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24115715, KAKENHI-PUBLICLY-24117704
  • [Journal Article] Double Plant Homeodomain (PHD) Finger Proteins DPF3a and -3b Are Required as Transcriptional Co-activators in SWI/SNF Complex-dependent Activation of NF-κB RelA/p50 Heterodimer2012

    • Author(s)
      Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H
    • Journal Title

      J.Biol.Chem.

      Volume: 287(15) Pages: 11924-11933

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Journal Article] Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF- RelA/p50 heterodimer.2012

    • Author(s)
      Ishizaka, A., Mizutani, T., Kobayashi, K., Tando, T., Sakurai, K., Fujiwara, T., and Iba, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 11924-11933

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300318
  • [Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF_KB pathway.2010

    • Author(s)
      Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iids, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J., Iba, H.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 21951-21960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300318
  • [Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF-〓B pathway.2010

    • Author(s)
      ando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J and Iba H.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 29 Pages: 21951-60

    • DOI

      10.1074/jbc.m109.087783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390148, KAKENHI-PROJECT-21590507, KAKENHI-PROJECT-22659094
  • [Journal Article] Requiem protein links ReIB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.2010

    • Author(s)
      Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H.
    • Journal Title

      J. Biol. Chem.

      Volume: 285(29) Pages: 21951-21960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Journal Article] Requiem protein links RelB/p52 and theBrm-type SWI/SNF complex in a non-canonical NFκB pathway.2010

    • Author(s)
      Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iida, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J., and Iba, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 21951-21960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300318
  • [Journal Article] Loss of the Brm-Type SWI/SNF Chromatin Remodeling Complex Is a Strong Barrier to the Tat-Independent Transcriptional Elongation of Human Immunodeficiency Virus Type 1 Transcripts2009

    • Author(s)
      Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H
    • Journal Title

      JOURNAL OF VIROLOGY 83

      Pages: 11569-11580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Journal Article] LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development.2009

    • Author(s)
      Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H.
    • Journal Title

      Clin. Cancer Res. 15

      Pages: 4009-4016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regurate villin expression in gastrointestinal cells2009

    • Author(s)
      Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura. R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H.
    • Journal Title

      Experimental cell Reseach (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Journal Article] Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of HIV-1 transcripts2009

    • Author(s)
      Mizutani, T., Ishizaka, A., Tomizawa, M., Okazaki, T., Yamamichi, N., Kawana-Tachikawa, A., Iwamoto, A., Iba, H.
    • Journal Title

      Journal of Virology 83

      Pages: 11569-11580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells2009

    • Author(s)
      Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T., Ishizaka, A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Omata, M., Iab, H.
    • Journal Title

      Experimental Cell Research 315

      Pages: 1779-1789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.2009

    • Author(s)
      Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H.
    • Journal Title

      Exp. Cell Res. 315

      Pages: 1779-1789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development2009

    • Author(s)
      Yamamichi, N., Shimomura, R., Inada, K., Sakurai, K., Haraguchi, T., Ozaki, Y., Fujita, S., Mizutani, T., Furukawa, C., Fujishiro, M., Ichinose, M., Shiogama, K., Tsutsumi, Y., Omata, M., Iba, H
    • Journal Title

      Clinical Cancer Research 15

      Pages: 4009-4016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of HIV-1 transcripts.2009

    • Author(s)
      Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H.
    • Journal Title

      J of Virol. 83

      Pages: 11569-11580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and Ikappa Bzeta.2008

    • Author(s)
      Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K.
    • Journal Title

      J Biol Chem. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts inconcert with p54^<nrb>.2008

    • Author(s)
      Ito, T., Watanabe, H., Yamamichi, N., Kondo, S., Tando, T., Haraguchi, T., Mizutani, T., Sakurai, K., Fujita, S., Izumi, T., Isobe, T., and Iba, H.
    • Journal Title

      Biochemical J. 411

      Pages: 201-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism.2008

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H.
    • Journal Title

      J Mol Biol. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008

    • Author(s)
      Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamamichi, N., Sakurai, K. and Iba, H.
    • Journal Title

      J. Mol. Biol. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts inconcert with p54(nrb).2008

    • Author(s)
      Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba H.
    • Journal Title

      Biochem J. 411(1)

      Pages: 201-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba, H.
    • Journal Title

      J. Mol. Biol 378

      Pages: 492-504

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism2008

    • Author(s)
      Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamarnichi, N., Sakurai, K., and Iba, H.
    • Journal Title

      J.Mol.Biol. 378

      Pages: 492-504

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and IκBζ.2008

    • Author(s)
      Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H., Matsumoto M, Honda, K, Smale ST, Takeda, K.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 12468-12477

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54^<nrb>2008

    • Author(s)
      Ito, T., Watanabe, H., Yamamichi, N., Kondo, S. , Tando, T. ,H araguchi, T., Mizutani, T., Sakurai, K., Fujita, S., Izumi, T., Isobe, T., and Iba, H.
    • Journal Title

      Biochemical J. 411

      Pages: 201-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and IκBζ2008

    • Author(s)
      Kayama, H., Ramirez-Carrozzi, V.R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S.T., and Takeda, K.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 12468-12477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Class-specific regulation of pro-inflammatory genes by MYD88 pathways and lκBζ.2008

    • Author(s)
      Kayama, H., Ramirez-Carrozzi, V. R, Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S.T., and Takeda, K.
    • Journal Title

      J. Biol. Chem. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54nrb2008

    • Author(s)
      Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba H.
    • Journal Title

      Biochemical J. 411

      Pages: 201-209

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state.2007

    • Author(s)
      Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe H, Shiogama K, Fujishiro M, Okazaki T, Yahagi N, Haraguchi T, Fujita S, Tsutsumi Y, Omata M, Iba H.
    • Journal Title

      Cancer. Res. 67(22)

      Pages: 10727-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007

    • Author(s)
      Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba H.
    • Journal Title

      FEBS Lett. 581(25)

      Pages: 4949-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histological features and differentiation state.2007

    • Author(s)
      Yamamichi, N., Inada, K., Ichinose, M., Yamamichi-Nishina, M., Mizutani, T., Watanabe, H., Shiogama, K., Okazaki, T., Fujishiro, M., Yahagi, N., Haraguchi T., Fujita, S., Tsutsumi, Y., Omata, M. and Iba, H.
    • Journal Title

      Cancer Research 22

      Pages: 10727-10735

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007

    • Author(s)
      Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba, H.
    • Journal Title

      FEBS Letter 581

      Pages: 4949-4954

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] RNA-dependent transcriptional silencing does not contribute to retroviral gene silencing in human cells.2007

    • Author(s)
      Haraguchi, T., Mizutani, T., Yamamichi, N., Ito, T., Minoguchi, S., and Iba, H.
    • Journal Title

      FEBS Letter 581

      Pages: 4949-4954

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] A protein associated with Toll-like Receptor 4 (PRAT4A) regulates cell surface expression of TLR4.2006

    • Author(s)
      Wakabayashi Y, Kobayashi M, Akashi-Takamura S, Tanimura N, Konno K, Takahashi K, Ishii T, Mizutani T, Iba, H, Kouro T, Takaki S, Takatsu K., Oda, Y., Ishihama, Y., Saitoh, S -I., Miyake, K.
    • Journal Title

      J. Immunol 177

      Pages: 1772-1779

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines.2006

    • Author(s)
      Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, Iba H.
    • Journal Title

      Oncogene 25

      Pages: 470-479

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits anti-oncogenic potential.2005

    • Author(s)
      Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose M, Omata M, Iba, H.
    • Journal Title

      Oncogene 24

      Pages: 5471-5481

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NFκB pathway.

    • Author(s)
      Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H.
    • Journal Title

      J Biol. Chem. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article]

    • Author(s)
      Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe, H., Shiogama K, Okazaki T, Fujishiro M, Yahagi N
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Ccbc2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells

    • Author(s)
      Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T. , Ishizaka , A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Ornata, M., and Iba, H.
    • Journal Title

      Exp. Cell Res. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Patent] 血液脳関門を透過する薬物輸送体、ペプチド及びその用途2017

    • Inventor(s)
      水谷壮利、石坂彩
    • Industrial Property Rights Holder
      公益財団法人微生物化学研究会
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15K14413
  • [Presentation] SARS-CoV-2感染がPLWHに及ぼす腸内細菌叢変化と病態との相関関係2023

    • Author(s)
      水谷壮利, 石坂彩, 古賀道子, 山吉誠也, 岩附研子, 安達英輔, 鈴木穣, 河岡義裕, 四柳宏
    • Organizer
      日本エイズ学会
    • Data Source
      KAKENHI-PROJECT-21K11592
  • [Presentation] SARS-CoV-2罹患による腸内細菌叢と炎症惹起の動態解析2021

    • Author(s)
      水谷 壮利、古賀 道子、石坂 彩、山吉誠也、岩附 研子、安原 敦洋、池内 和彦、齋藤 真、安達 英輔、堤 武也、清野 宏、俣野 哲朗、河岡義裕、四柳 宏
    • Organizer
      第35回日本エイズ学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K11592
  • [Presentation] HIV-1 promoter is negatively regulated by hnRNPA1 in Tat independent mannor.2011

    • Author(s)
      Mizutani, T., Ishizaka, A., and Iba, H.
    • Organizer
      日本ウイルス学会学術集会(IUMS Sapporo)
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-11
    • Data Source
      KAKENHI-PROJECT-22300318
  • [Presentation] HIV-のTat非依存的な発現におけるSWI/SNF複合体の作用点の解析2010

    • Author(s)
      水谷壮利、石坂彩、伊庭英夫
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県あわぎんホール
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Presentation] Analysis for the regulation of transcriptional elongation of HIV-1 transcript by proyiral non-coding RNA2010

    • Author(s)
      Mizutani T, Ishizaka A, Iba H
    • Organizer
      The 10^<th> Awajishima International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路島夢舞台国際会議場
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Presentation] Analysis for the regulation of transcriptional elongation of HIV-1 transcript by proviral non-coding RNA2010

    • Author(s)
      Mizutani T, Ishizaka A, and Iba H
    • Organizer
      The 10th Awajishima International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路島夢舞台国際会議場
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Presentation] HIVのTat非依存的な発現におけるSWI/SNF複合体の作用点の解析2009

    • Author(s)
      水谷壮利、石坂彩、富沢麻利子、立川(川名)愛、岩本愛吉、伊庭英夫
    • Organizer
      第57回 日本ウイルス学会学術集会
    • Place of Presentation
      東京都 都市センターホテル
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Presentation] HIV-1 Tat非依存的な発現におけるSWI/SNF複合体の作用点の解析2009

    • Author(s)
      水谷壮利
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] The Brm-type SWI/SNF chromatin remodeling complex plays an important role in transcriptional elongation of HIV-1 in the absence of Tat.2009

    • Author(s)
      Ishizaka A, Mizutani T, Tomizawa M, Kawana-Tachikawa A, Iwamoto A, Iba H
    • Organizer
      The 9^<th> Awajishima International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県 淡路島夢舞台国際会議場
    • Data Source
      KAKENHI-PROJECT-21590507
  • [Presentation] Requiem functions in a non-canonical NFκB pathway as a linker protein between Rel/p52 and the SWI/SNF complex2009

    • Author(s)
      丹藤利夫、石坂彩、原口健、水谷壮利、秋山泰身、井上純一郎、伊庭英夫
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] The Brin-type SWI/SNF chromatin remodeling complex plays an important role in transcriptional elongation of HIV-1 in the absence of Tat2009

    • Author(s)
      Ishizaka, A., Mizutani, T., Tomizawa, M., Kawana-Tachikawa, A., Iwamoto, A., Iba, H.
    • Organizer
      The 9^<th> Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路島
    • Year and Date
      2009-09-08
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] The Brm-type SWI/SNF chromatin remodeling complex plays an important role in transcriptional elongation of HIV-1 in the absence of Tat2009

    • Author(s)
      Ishizaka, A., Mizutani, T., Tomizawa, M., Kawana-Tachikawa, A., Iwamoto, A., Iba, H.
    • Organizer
      The 9thAwaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路島
    • Year and Date
      2009-09-08
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Requiem functions in anon-canonical NFκB pathway as a linker protein between Rel/p52 and the SWI/SNF complex2009

    • Author(s)
      丹藤利夫、石坂彩、原口健、水谷壮利、秋山泰身、井上純一郎、伊庭英夫
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Brm, a catalytic subunit of SVI/SNF complex is required for Tat-independent stable expression of HIV-12008

    • Author(s)
      水谷壮利、石坂彩、山道信毅、伊庭英夫
    • Organizer
      The 8^<th> Awaiishima International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路島夢舞台国際会議場
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Presentation] HIV-1のTat非依存的な発現を維持するSWI/SNF複合体の作用機序の解析2008

    • Author(s)
      石坂彩、水谷壮利、山道信毅、原口健、富沢麻利子、岩本愛吉、伊庭英夫
    • Organizer
      第5回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Brm, a catalytic subunit of the SWI/SNF complex is required for Tat-independent stable expression of HIV-12008

    • Author(s)
      Mizutani, T., Ishizaka, A., Tomizawa, M., Yamamichi, N., Tando, T., Iwamoto, A., and Iba, H.
    • Organizer
      China-Japan ajoint Workshop on New-Generation Vaccines for Infectious Diseases
    • Place of Presentation
      北京
    • Year and Date
      2008-05-22
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] miRNAが形成する制御ネットワークとがん2008

    • Author(s)
      伊庭英夫、藤田修二、山道信毅、櫻井浩平、水谷壮利
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] HIV-1のTat非依存的な発現を維持するSWI/SNF複合体の作用点の解析2008

    • Author(s)
      石坂彩、水谷壮利、山道信毅、原口健、富沢麻利子、岩本愛吉、伊庭英夫
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism Systems Biology2007

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Iba H.
    • Organizer
      Global Regulation of Gene Expression
    • Place of Presentation
      New York, USA
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Brm, a catalytic subunit of SWI/SNF complex is required for Tat-independent stable expression of HIV-12007

    • Author(s)
      水谷 壮利、石坂 彩、山道信毅、伊庭英夫
    • Organizer
      The 7th Awajishima International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県 淡路島夢舞台国際会議場
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Presentation] High expression of miR-21 was detected in colorectal carcinoma but not in adenoma by LNA-based in situhybridization2007

    • Author(s)
      山道信毅、下村龍一、水谷壮利、稲田健一、藤田修二、櫻井浩平、一瀬雅夫、堤寛、小俣政男、伊庭英夫
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] HIV-1のTat非依存的な発現におけるSWI/SNF複合体の機能解析2007

    • Author(s)
      水谷壮利、石坂彩、山道信毅、原口健、伊庭英夫
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Brm, a catalytic subunit of the SWI/SNF complex is required for Tat-independent stable expression of HIV-12007

    • Author(s)
      Mizutani T, Ishizaka A, Yamamichi N, Okazaki T, Iba H.
    • Organizer
      第7回淡路島感染・免疫フォーラム
    • Place of Presentation
      兵庫
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] レトロウイルス遺伝子発現の不安定性の解析2007

    • Author(s)
      岡崎拓矢、山道信毅、水谷壮利、石坂彩、古川千尋、伊庭英夫
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] AP-1 triggers the sustained transcription of miR-21 through an evolutionarily conserved feedback mechanism2007

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H.
    • Organizer
      The 11th German-Japanese Cancer Workshop
    • Place of Presentation
      京都
    • Year and Date
      2007-11-30
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] HIV-1のTat非依存的な発現におけるSWI/SNF複合体の機能解析2007

    • Author(s)
      水谷 壮利、石坂 彩、山道信毅、伊庭英夫
    • Organizer
      第55回 日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-19041020
  • [Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism2007

    • Author(s)
      Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamanichi, N., Iba, H.
    • Organizer
      Systems Biology: Global Regulation of Gene Expression 2007 April
    • Place of Presentation
      New York
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] 胃癌におけるクロマチン構造変換因子SWI/SNF複合体の触媒サブユニットBrm欠失:癌化におけるBrm欠失の役割2006

    • Author(s)
      山道信毅、稲田健一、渡部博貴、山道(仁科)光恵、水谷壮利、矢作直久、一瀬雅夫、堤寛、小俣政男、伊庭英夫
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] SWI/SNF複合体の触媒サブユニットBrmはTERT遺伝子の転写と選択的スプライシングに関与する2006

    • Author(s)
      伊藤太二、渡部博貴、山道信毅、近藤俊輔、板垣千春、丹藤利夫、水谷壮利、原口健、櫻井浩平、藤田修二、泉友則、礒辺俊明、伊庭英夫
    • Organizer
      日本分子生物学会2006フォーラム(分子生物学の未来)
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] レトロウイルスプロモーターサイレンシングにおけるRNAi機構の役割の検証2006

    • Author(s)
      原口健、水谷壮利、伊庭英夫
    • Organizer
      第54回日本ウイルス学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] クロマチン構造変換因子SWI/SNF複合体のHIV-1発現維持機構の機能解析2006

    • Author(s)
      水谷壮利、石坂彩、山道信毅、岡崎拓矢、伊庭英夫
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] 多くのヒト癌で高レベルに発現するmir-21遺伝子のプロモーター解析とmir-21の標的遺伝子の同定2006

    • Author(s)
      伊庭英夫、藤田修二、伊藤太二、水谷壮利
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] ヒト癌細胞株で転写後抑制を受けているSWI/SNF複合体の触媒サブユニットBrmは、HDAC阻害剤により発現誘導され抗癌活性を示す2005

    • Author(s)
      山道信毅、水谷壮利、渡部博貴、伊藤太二、矢作直久、一瀬雅夫、小俣政男、伊庭英夫
    • Organizer
      第64回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] ES細胞に感染したレトロウイルスに見られるDNAメチル化に依存した可逆的ジーンサイレンシング2005

    • Author(s)
      箕口滋、渡部博貴、水谷壮利、伊庭英夫
    • Organizer
      第28回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] BrmとBRG1の発現を共に欠失するヒト非小細胞肺がん細胞株における神経特異的遺伝子群の発現誘導とその機構2005

    • Author(s)
      渡部博貴、水谷壮利、山道信毅、伊庭英夫
    • Organizer
      第64回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Unique expression mechanisms of Brm protein, a key regulatory host factor for continuous retroviral expression2005

    • Author(s)
      Yamamichi N, Mizutani T, Yamamichi-Nishina M, Haraguchi T, Kameda T, Iba H.
    • Organizer
      第5回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] レトロウイルスの発現維持に必須な宿主因子Brmの特異な生合成過程2005

    • Author(s)
      伊庭英夫、山道信毅、水谷壮利、原口健
    • Organizer
      第53回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2005-11-22
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] p54nrbとSWI/SNF複合体の相互作用とその生化学的意義2005

    • Author(s)
      伊藤太二、渡部博貴、山道信毅、近藤俊輔、板垣千春、丹藤利夫、水谷壮利、原口健、藤田修二、泉友則、礒辺俊明、伊庭英夫
    • Organizer
      第28回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Reversible switching of MSCV Proviral Expression Reflects Dynamics of DNA Methylation in Embryonic Stem Cells2005

    • Author(s)
      箕口滋、渡部博貴、水谷壮利、伊庭英夫
    • Organizer
      文部科学省特定領域研究「幹細胞の可塑性と未分化性維持機構」国際シンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-17016015
  • 1.  IBA Hideo (60111449)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  MINOGUCHI Shigeru (60322757)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 3.  ITO Taiji (60343109)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 4.  HARAGUCHI Takeshi (10549455)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 23 results
  • 5.  YAMAMICHI Nobutake (30463897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 35 results
  • 6.  KOHARA Michinori (10250218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  INADA Kenichi (70246081)
    # of Collaborated Projects: 1 results
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  • 8.  ISOBE Yoshiaki (70106607)
    # of Collaborated Projects: 1 results
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  • 9.  KIYAMA Noubuko
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  • 10.  伊庭 英生
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    # of Collaborated Products: 70 results
  • 11.  古賀 道子
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  • 12.  石坂 彩
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  • 13.  秋山 泰身
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  • 14.  井上 純一郎
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  • 15.  堤 武也
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