• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

TAKEHISA Yasushi  武久 康

ORCIDConnect your ORCID iD *help
Researcher Number 00379752
Affiliation (based on the past Project Information) *help 2010: Okayama University, 大学病院, 助教
2007 – 2008: 岡山大学, 医学部・歯学部附属病院, 助教
2005 – 2006: 岡山大学, 医学部・歯学部附属病院, 助手
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Neurology
Keywords
Principal Investigator
SODG93A transgenic mice / FNK / IGF-1 / intrathecal infusion / neurotrophic factors / neural precursor cell / ant-apoptotic therapy / ALS / 筋萎縮性側索硬化症(ALS) / 抗アポトーシス治療法 … More / 髄腔内投与 / 神経栄養因子 / 再生治療 / 抗アポトーシス治療 / 筋萎縮性側索硬化症 … More
Except Principal Investigator
EGF / FGF2 / 分化 / 神経幹細胞 / 診断マーカー / 小胞体ストレス / ミトコンドリア / オートファジー / TAT蛋白 / protein transduction domain / TRIAD / 再生療法 / 遺伝子療法 / 蛋白療法 / トランスジェニックマウス / SOD1 / ALS / 筋萎縮性側索硬化症 / 神経分子病態学 Less
  • Research Projects

    (3 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (7 People)
  •  家族性筋萎縮性側索硬化症におけるレビー小体様硝子封入体の生成機構に関する研究Principal Investigator

    • Principal Investigator
      武久 康
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Okayama University
  •  Molecular characterization and gene/regeneration therapy for amyotrophic lateral sclerosis

    • Principal Investigator
      ABE Koji
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Okayama University
  •  Anti-apoptotic Therapy (Intrathecal Injection of Anti-apoptotic PTD-FNK Protein) in a Mouse Model of Amyotrophic Lateral SclerosisPrincipal Investigator

    • Principal Investigator
      TAKEHISA Yasushi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Okayama University

All 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene.2009

    • Author(s)
      Morimoto N, Nagai M, Mlyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T Okazawa H Abe K
    • Journal Title

      J Neurosci Res. 87

      Pages: 928-936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene2009

    • Author(s)
      Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Okazawa H, Abe K.
    • Journal Title

      J Neurosci Res 87

      Pages: 928-936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Differentiation of PA from early PSP with different patterns of symptomsand CBF reduction.2008

    • Author(s)
      Kurata T, Hayashi T. Murakaoi T, Miyazaki K, Morinoto N, Ohta Y. Takehisa Y, Nagai M, Kanarabayashi T, Takao Y. Ohta. T, Harigaya Y. Manabe Y, Kamiya T. Shoji M, Abe K.
    • Journal Title

      Neurol Res. 30

      Pages: 860-867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article]2008

    • Author(s)
      Kurata T, Hayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Kawarabayashi T, Takao Y, Ohta T, Harigaya Y, Manabe Y, Kamiya T, Shoji M, Abe K.
    • Journal Title

      Neurol Res 30

      Pages: 860-867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis2008

    • Author(s)
      Ohta Y, Kamiya T, Nagai M, Nagata T, Morimoto N, Miyazaki K, Murakami T, Kurata T, Takehisa Y, Ikeda Y, Asoh S, Ohta S, Abe K.
    • Journal Title

      J Neurosci Res 86

      Pages: 3028-3037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis.2008

    • Author(s)
      Ohta Y, Kamiya T, Nagai K. Nagata T, Norimoto N, Miyazaki K. Murakami T, Kurata T. Takehisa Y, Iksda Y, Asoh s. Ohta S, Abe K.
    • Journal Title

      J Neurosci Res. 86

      Pages: 3028-3037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation- associated familial amyotrophic lateral sclerosis and its transgenic mouse model.2007

    • Author(s)
      Shibata N, Kawaguchi M, Uchida K, Kakita A, Takahashi H, Nakano R, Fujimura H, Sakoda S, Ihara Y, Nobukuni K, Takehisa Y, Kuroda S, Kokubo Y, Kuzuhara S, Honma T, Mochizuki Y, Mizutani T, Yamada S, Toi S, Sasaki S, Iwata M, Hirano A, Yamamoto T, Kato Y, Sawada T, Kobayashi M
    • Journal Title

      Neuropathology. 27

      Pages: 49-61

    • NAID

      10021235172

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.2007

    • Author(s)
      Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Abe K
    • Journal Title

      Brain Res. 8(Epub ahead of prin)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in □-synucleinopathy brains.2007

    • Author(s)
      Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe
    • Journal Title

      J Neurol Neurosurg Psychiatry. 8 (Epub ahead of prin)

    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor prtotein and presenilin-1.2007

    • Author(s)
      Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai N, Ikeda M, Natsubara E, Westaway D, Hyslop PS, Harigaya Y, Kamiya T, Shoji M, Abe K
    • Journal Title

      J Neurosci Res 85

      Pages: 2246-2252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Increased autophagy in transgenic mice with a G93A mutant SOD1 gene2007

    • Author(s)
      Morimoto N, Nagai M, Ohta Y, Miyazaki K, Kurata T, Morimoto M, Murakami T, Takehisa Y, Ikeda Y, Kamiya T, Abe K.
    • Journal Title

      Brain Res 1167

      Pages: 112-117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.2007

    • Author(s)
      Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Ahe K
    • Journal Title

      Brain Res 1150

      Pages: 182-189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Two cases of spinocerebellar ataxiaccompanied by involvement of the skeletal motor neuron system and bulbar palsy2007

    • Author(s)
      Ohta Y, Hayashi T, Nagai M, Okamoto M, Nagotani S, Nagano I, Ohmori N, TakehisaY, Murakami T, Shoji M, Kamiya T, and Abe K.
    • Journal Title

      Intern Med 46

      Pages: 751-755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Two cases of spinocerebellar ataxia accompanied by involvement of the skeletal motor neuron system and bulbar palsy.2007

    • Author(s)
      Ohta Y, Hayashi T, Nagai M, Okamoto M, Nagotani S, Nagano I, Ohmori N, Takehisa Y, Murakami T, Shoji M, Kamiya T, and Abe K
    • Journal Title

      Intern Med 46

      Pages: 751-755

    • NAID

      130000076727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model.2007

    • Author(s)
      Shibata N, Kawaguchi M, Uchida K, Kakita A, Takahashi H, Nakano R, Fujimura H, Sakoda S, Ihara Y, Nobukuni K, Takehisa Y, Kuroda S, Kokubo Y, Kuzuhara S, Honma T, Mochizuki Y, Mizutani T, Yamada S, Toi S, Sasaki S, Iwata M, Hirano A, Yamamoto T, Kato Y, Sawada T, Kobayashi M.
    • Journal Title

      Neuropathology. 27

      Pages: 49-61

    • NAID

      10021235172

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model.2007

    • Author(s)
      Shibata N, Kgwaguchi M, Uchida K, Kakita A, Takahashi H, Nakano R, Fujimura H, Sakoda S, Ihara Y, Nobukuni K, Takehisa Y, Kuroda S, Kokubo Y, Kuzuhara S, Honma T, Mochizuki Y, Mizutani T, Yamada S, Toi S, Sasaki S, Iwata M, Hirano A, Yamamoto T, Kato Y, Sawada T, Kobayashi M.
    • Journal Title

      Neuropathology. 27

      Pages: 49-61

    • NAID

      10021235172

    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] Enhanced accumulation ophosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-12007

    • Author(s)
      Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, Hyslop PS, Harigaya Y, Kamiya T, Shoji M, Abe K.
    • Journal Title

      J Neurosci Res 85

      Pages: 2246-2252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.2007

    • Author(s)
      Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Abe K.
    • Journal Title

      Brain Res. 8 (Epub ahead of prin)

    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in □-synucleinopathy brains.2007

    • Author(s)
      Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe
    • Journal Title

      J Neurol Neurosurg Psychiatry. 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.2007

    • Author(s)
      Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Abe K.
    • Journal Title

      Brain Res. 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in □-synucleinopathy brains.2007

    • Author(s)
      Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta, Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe
    • Journal Title

      J Neurol Neurosurg Psychiatry. 8(Epub ahead of prin)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590879
  • [Journal Article] Increased autophagy in transgenic mice with a G93A mutant SOD1 gene.2007

    • Author(s)
      Morimoto N, Nagai M, Ohta Y, Miyazaki K, Kurata T, Morimoto M, Murakami T, Takehisa Y, Ikeda Y, Kamiya T, Abe K
    • Journal Title

      Brain Res 1167

      Pages: 112-117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Journal Article] Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene2007

    • Author(s)
      Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Abe K.
    • Journal Title

      Brain Res 1150

      Pages: 182-189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Increased autophagy in transgenic mice with a G93A mutant SOD1 gene2008

    • Author(s)
      Morimoto N, Nagai M, Miyazaki K, KurataT, Takehisa Y, Ikeda Y, Kamiya T, Abe K.
    • Organizer
      12th Congress of the European Federation of Neurologica Societies
    • Place of Presentation
      Madrid, Spain
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Increased autophagy in transgenic mice with a G93A mutant SOD1 gene.2008

    • Author(s)
      Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Abe K.
    • Organizer
      12th Congress of the European Federation of Neurological Societies
    • Place of Presentation
      Madrid, Spain
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Enhanced accumulation of phosphorylated α-synuclein in transgenic mice expressing APP and PS-1.2007

    • Author(s)
      Kurata T, Kawarabayashi T, Nurakami T, Morimoto N, Ota Y, Ikeda Y, Nagai N, Takehisa Y, Matsubara E, David Westaway, Peter St. George Hyslop, Harigaya Y, Kamiya T, Shoji M, and Abe K
    • Organizer
      13th Congress of International Psychogeriatric Association
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Beneficial Effectsof Intrathecal Administration in Patientswith Amyotrophic Lateral Screlosis2007

    • Author(s)
      Morimoto N, Nagano I, Murakami T, Nagai M, Shiote M, Ohta Y, Morimoto M, Takehisa Y, Kamiya T, and Abe K.
    • Organizer
      The 23rd International Symposium on CereBlood Flow, Metabolism and ThInternational Conference on Quantification of Brain Funct
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Beneficial Effects of Intrathecal Administration in Patients with Amyotrophic Lateral Screlosis.2007

    • Author(s)
      Morimoto N, Nagano I, Murakami T, Nagai M, Shiote M, Ohta Y, Morimoto M, Takehisa Y, Kamiya T, and Abe K
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism and The 8th International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Dysfunction of mitochondrial oxidative phosphorylation in ALS rat model.2007

    • Author(s)
      Nagai M, Murakami T, Ohta Y, Takehisa Y, Morimoto N, Miyazaki K, Kurata T, Kamiya T, Abe K, and Przedborski S
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism and The 8th International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Familial ALS with a novel Leu126Ser mutation in the SOD1 gene showing mild clinical features and low penetrance in females2007

    • Author(s)
      Takehisa Y, Murakami T, Nagai M, Ohta Y, Morimoto N, Ikeda Y, Kamiya T, and Abe K.
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism8th International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Dysfunction ofmitochondrial oxidative phosphorylation in ALS rat model2007

    • Author(s)
      Nagai M, Murakami T, Ohta Y, Takehisa Y, Morimoto N, Miyazaki K, Kurata T, Kamiya T, Abe K, and Przedborski S.
    • Organizer
      The 23rd InternatSymposium on Cerebral Blood Flow, Metabolism and The 8th International Conference on Quantification of Brain Functio with PET
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Enhanced accumulation of phosphorylated α-synuclein in transgenic mice eAPP and PS-12007

    • Author(s)
      Kurata T, Kawarabayashi T, Murakami T, Morimoto N, Ota Y, Ikeda Y, Nagai M, Takehisa Y, Matsubara E, David Westaway, Peter St. George Hyslop, Harigaya Y, T, Shoji M, and Abe K.
    • Organizer
      13th Congress of International Psychogeriatric
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Familial ALS with a novel Leu126Ser mutation in the SOD1 gene showing mild clinical features and low penetrance in females.2007

    • Author(s)
      Takehisa Y, Murakami T, Nagai M, Ohta Y, Morimoto N, Ikeda Y, Kamiya T, and Abe K
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism and The 8th International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Beneficial effects of intrathecal IGF-1 administration inpatients with amyotrophic lateralsclerosis2006

    • Author(s)
      Murakami T, Nagano I, Nagai M, Shiote M, Ohta Y, Morimoto N, Takehisa Y, Kaand Abe K.
    • Organizer
      17^<th> International Symposium on ALS/MND
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Enhanced accumulation of phosphorylated α-synuclein in transgenic mice expressingAPP and PS-12006

    • Author(s)
      Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ota Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, St George Hyslop P, Harigaya Y, Kamiya T, Shoji M, and Abe K.
    • Organizer
      The 6^<th> Annual Meetingof International Collegeof Geriatric Psychoneuropharmacology
    • Place of Presentation
      Hiroshima, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • [Presentation] Accumulation of Parkinson's-disease-related moleculLewy bodies and glial cytoplasmic inclusions2006

    • Author(s)
      Murakami T, Imai Y, Inoue H, Kawarabayashi T, Nagai M, Kurata T, Takehisa Y, Harig Y, Shoji M, Takahashi Y, Harigaya Y, Shoji M, Takahashi R, and Abe K.
    • Organizer
      10^<th> International Congress of Parkinson's Disease and Movement
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-18390257
  • 1.  ABE Koji (20212540)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 32 results
  • 2.  NAGAI Makiko (80420488)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 33 results
  • 3.  MURAKAMI Tetsuro (70403475)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 27 results
  • 4.  KAMIYA Tatsushi (70233955)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 24 results
  • 5.  IKEDA Yoshio (00282400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results
  • 6.  HAYASHI Takeshi (40314679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  瓦林 毅 (90186156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi