Takekuma Yoh 武隈洋

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TAKEKUMA Yoh 武隈洋

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Researcher Number	00396293
Other IDs
Affiliation (Current)	2025: 北海道大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 北海道大学, 大学病院, 准教授 2016 – 2018: 北海道大学, 薬学研究院, 准教授 2015: 北海道大学, 大学院薬学研究院, 准教授 2012 – 2015: 北海道大学, 薬学研究科(研究院), 准教授
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator 唾液 / 薬物濃度モニタリング / 血小板減少症 / TDM / テジゾリド / リネゾリド / 唾液中濃度 / グルクロン酸転移酵素 / 薬物代謝 / グルクロン酸抱合 / 生細胞 / UGT … More Except Principal Investigator … More 代謝酵素 / 小腸上皮細胞 / ｐ-糖タンパク質 / トランスポーター / エンテロイド / シクロホスファミド / 造血幹細胞移植 / 白血病 / 細胞周期 / エトポシド Less

唾液中薬物濃度モニタリングが適用可能な薬物の選択方法の確立Principal Investigator
- Principal Investigator
  
  武隈洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
Therapeutic drug monitoring of anti-MRSA agents, oxazolidinones by salivary concentration, and dose optimizationPrincipal Investigator
- Principal Investigator
  
  Takekuma Yoh
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
Establishment of a new method using enteroid for drug transport analysis in the small intestine epithelium
- Principal Investigator
  
  Sugawara Mitsuru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Optimization of drug administration order in anti-cancer drug combination therapy in hematopoietic stem cell transplantation
- Principal Investigator
  
  SUGAWARA Mitsuru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Evaluation of variation of glucuronidation activity and substrate specificity caused by difference in the proportion of expression level of UGT isozimes in living cellsPrincipal Investigator
- Principal Investigator
  
  TAKEKUMA Yoh
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University

All 2023 2022 2019 2018 2017 2015 2014 Other

All Journal Article Presentation

[Journal Article] Monitoring Salivary Concentrations of Tedizolid and Linezolid Using Rats2023
- Author(s)
  Inoue Yuki、Sato Yuki、Kashiwagi Hitoshi、Nashimoto Shunsuke、Sugawara Mitsuru、Takekuma Yoh
- Journal Title
  
  European Journal of Drug Metabolism and Pharmacokinetics
  
  Volume: 48 Issue: 4 Pages: 387-395
- DOI
  10.1007/s13318-023-00836-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06684
[Journal Article] Use of Japanese big data from electronic medical records to investigate risk factors and identify their high-risk combinations for linezolid-induced thrombocytopenia2023
- Author(s)
  Inoue Yuki、Takekuma Yoh、Miyai Takayuki、Kashiwagi Hitoshi、Sato Yuki、Sugawara Mitsuru、Imai Shungo
- Journal Title
  
  European Journal of Clinical Pharmacology
  
  Volume: 79 Pages: 415-425
- DOI
  10.1007/s00228-023-03455-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06684
[Journal Article] Schedule-Dependent Cytotoxicity of Etoposide and Cyclophosphamide in P-Glycoprotein-Expressing Human Leukemic K-562 Cells2014
- Author(s)
  Yuki Tazawa, Ippei Usukubo, Kazuki Takada, Yoh Takekuma, Yoshihiro Shibayama, Mitsuru Sugawara
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 8 Pages: 1323-1329
- DOI
  10.1248/bpb.b14-00207
- NAID
  130004677540
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460203
[Presentation] Monitoring saliva and plasma concentrations of tedizolid and linezolid in rats2023
- Author(s)
  Yuki Inoue, Yuki Sato, Hitoshi Kashiwagi, Shunsuke Nashimoto, Mitsuru Sugawara, Yoh Takekuma
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06684
[Presentation] 唾液サンプリングに基づくTDMの実際2023
- Author(s)
  武隈洋、井上優希、菅原満
- Organizer
  第39回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-21K06684
[Presentation] ビッグデータとデータマイニング手法を用いたリネゾリド誘発性血小板減少症の要因分析2022
- Author(s)
  井上優希、武隈洋、宮井貴之、柏木仁、佐藤夕紀、菅原満、今井俊吾
- Organizer
  日本薬学会　第142年会
- Data Source
  KAKENHI-PROJECT-21K06684
[Presentation] エンテロイドを用いた薬物排出トランスポーターの機能解析2019
- Author(s)
  小関千尋、石川岳彦、佐藤夕紀、武隈　洋、菅原　満
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08363
[Presentation] エンテロイドは薬物排出トランスポーターの解析ツールになり得るか2018
- Author(s)
  小関千尋、石川岳彦、佐藤夕紀、武隈　洋、菅原　満
- Organizer
  第32回北海道薬物作用談話会
- Data Source
  KAKENHI-PROJECT-16K08363
[Presentation] 慢性骨髄性白血病治療薬ダサチニブの消化管吸収に及ぼす消化管内pHおよびトランスポーターの影響2017
- Author(s)
  助畑　歩、武隈　洋、鷲見正人、佐藤夕紀、菅原　満
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08363
[Presentation] TDMへの応用を目指した３種のチロシンキナーゼ阻害剤の血中濃度測定法の検証2015
- Author(s)
  助畑　歩、武隈　洋、佐藤夕紀、鷲見正人、田中寛之、遠藤雅之、菅原　満
- Organizer
  日本薬学会北海道支部第142回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-25460203
[Presentation] 細胞周期変化がエトポシド（VP-16）の殺細胞効果に与える影響2014
- Author(s)
  田澤佑基、吉岡美咲、武隈　洋、佐藤夕紀、鷲見正人、菅原　満
- Organizer
  日本薬学会北海道支部第141回例会
- Place of Presentation
  札幌
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25460203
[Presentation] 細胞周期変化がエトポシド（VP-16）の殺細胞効果に与える影響2014
- Author(s)
  田澤佑基，吉岡美咲，武隈　洋，佐藤夕紀，鷲見正人，菅原　満
- Organizer
  日本薬学会北海道支部第141回例会
- Place of Presentation
  札幌，札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-25460203
[Presentation] 薬物曝露による細胞周期変化が細胞周期依存性の抗癌剤の作用に与える影響
- Author(s)
  吉岡美咲，田澤佑基，佐藤夕紀，鷲見正人，武隈　洋，菅原　満
- Organizer
  第27回北海道TDM研究会研究発表会
- Place of Presentation
  札幌，北海道薬科大学サテライトキャンパス
- Data Source
  KAKENHI-PROJECT-25460203
[Presentation] 中等量エトポシド (VP-16)/シクロホスファミド (CY)/全身放射線(TBI)前処置レジメンにおけるVP-16のPK/PD解析による投与量の最適化に関する検討
- Author(s)
  田澤佑基、武隈　洋、佐藤夕紀、鷲見正人、笠師久美子、井関　健、菅原　満
- Organizer
  第22回クリニカルファーマシーシンポジウム/医療薬学フォーラム
- Place of Presentation
  東京
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-25460203

1. SUGAWARA Mitsuru (60332467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. 佐藤夕紀 (00564981)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 今井俊吾 (40845070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 柏木仁 (60510609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIKAWA takehiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. KOSEKI chihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Takekuma Yoh 武隈 洋

TAKEKUMA Yoh 武隈 洋

Research Projects

Research Products

Co-Researchers

唾液中薬物濃度モニタリングが適用可能な薬物の選択方法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic drug monitoring of anti-MRSA agents, oxazolidinones by salivary concentration, and dose optimizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a new method using enteroid for drug transport analysis in the small intestine epithelium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Optimization of drug administration order in anti-cancer drug combination therapy in hematopoietic stem cell transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of variation of glucuronidation activity and substrate specificity caused by difference in the proportion of expression level of UGT isozimes in living cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Monitoring Salivary Concentrations of Tedizolid and Linezolid Using Rats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of Japanese big data from electronic medical records to investigate risk factors and identify their high-risk combinations for linezolid-induced thrombocytopenia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Schedule-Dependent Cytotoxicity of Etoposide and Cyclophosphamide in P-Glycoprotein-Expressing Human Leukemic K-562 Cells2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] Monitoring saliva and plasma concentrations of tedizolid and linezolid in rats2023

Author(s)

Organizer

Data Source

[Presentation] 唾液サンプリングに基づくTDMの実際2023

Author(s)

Organizer

Data Source

[Presentation] ビッグデータとデータマイニング手法を用いたリネゾリド誘発性血小板減少症の要因分析2022

Author(s)

Organizer

Data Source

[Presentation] エンテロイドを用いた薬物排出トランスポーターの機能解析2019

Author(s)

Organizer

Data Source

[Presentation] エンテロイドは薬物排出トランスポーターの解析ツールになり得るか2018

Author(s)

Organizer

Data Source

[Presentation] 慢性骨髄性白血病治療薬ダサチニブの消化管吸収に及ぼす消化管内pHおよびトランスポーターの影響2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] TDMへの応用を目指した３種のチロシンキナーゼ阻害剤の血中濃度測定法の検証2015

Takekuma Yoh 武隈洋

TAKEKUMA Yoh 武隈洋