Doi Tomoko 土井知子

… Alternative Names

DOI Tomoko 土井知子

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Researcher Number	00397580
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2022: 京都大学, 理学研究科, 准教授 2014 – 2015: 京都大学, 理学(系)研究科(研究院), 准教授 2007 – 2009: Kyoto University, 大学院・理学研究科, 准教授
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 43030:Functional biochemistry-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 受容体薬理学 / シグナル伝搬 / ペプチドGPCR / GPCR / 分子標的治療 / シグナル伝達 / 三量体Gタンパク質 / 血管内皮細胞 / エンドセリン / 3量体Gタンパク質 … More / ペプチドホルモン / 構造変化 / アゴニスト / アンタゴニスト / ナノディスク / エンドセリン受容体 / タンパク / タンパク質 / 脳神経疾患 / 神経科学 / PSD-95 / MAGUKファミリー / シナプス後肥厚 / シナプス可塑性 / PDZドメイン Less

Studies of activation mechanism of vascular-constricting hormone receptorPrincipal Investigator
- Principal Investigator
  
  Doi Tomoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kyoto University
Studies of prerequisites for ETB agonists to accelerate anti-cancer therapyPrincipal Investigator
- Principal Investigator
  
  Doi Tomoko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University
Challenge for heterodimer formation of endothelin receptors in nanodiscsPrincipal Investigator
- Principal Investigator
  
  Doi Tomoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University
Regulation of synaptic transmission by the scaffolding protein PSD-95Principal Investigator
- Principal Investigator
  
  DOI Tomoko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto University

All 2020 2018 2017 2016 2015 2010 2009 2007

All Journal Article Presentation

[Journal Article] Characterization of critical residues in the extracellular and transmembrane domains of the endothelin type-B receptor for propagation of the endothelin-1 signal2020
- Author(s)
  Tomoko Doi, Kohei Kikuta, and Kazutoshi Tani
- Journal Title
  
  Biochemistry
  
  Volume: － Issue: 18 Pages: 1718-1727
- DOI
  10.1021/acs.biochem.0c00158
- NAID
  120006885414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07172, KAKENHI-PROJECT-20H03210
[Journal Article] エンドセリン受容体の初期活性化機構2017
- Author(s)
  土井知子、谷一寿
- Journal Title
  
  医学のあゆみ
  
  Volume: 262 Pages: 812-813
- Data Source
  KAKENHI-PROJECT-16K07172
[Journal Article] X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog2017
- Author(s)
  Shihoya Wataru、Nishizawa Tomohiro、Yamashita Keitaro、Inoue Asuka、Hirata Kunio、Kadji Francois Marie Ngako、Okuta Akiko、Tani Kazutoshi、Aoki Junken、Fujiyoshi Yoshinori、Doi Tomoko、Nureki Osamu
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 24 Issue: 9 Pages: 758-764
- DOI
  10.1038/nsmb.3450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07172, KAKENHI-PROJECT-17K19347, KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17J30010, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-17H05000
[Journal Article] Thermostabilization of the human endothelin type-B receptor2016
- Author(s)
  Akiko Okuta, Kazutoshi Tani, Shoko Nishimura, Yoshinori Fujiyoshi, and Tomoko Doi*
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: in press Issue: 11 Pages: 1-10
- DOI
  10.1016/j.jmb.2016.03.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26640102, KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-26440024, KAKENHI-PROJECT-16K07172
[Journal Article] Activation mechanism of endothelin ETB receptor by endothelin-1.2016
- Author(s)
  W. Shihoya, T. Nishizawa, A. Okuta, K. Tani, N. Dohmae, Y. Fujiyoshi, O. Nureki and T. Doi
- Journal Title
  
  Nature
  
  Volume: 537 Issue: 7620 Pages: 363-368
- DOI
  10.1038/nature19319
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-15J09780, KAKENHI-PROJECT-26440024, KAKENHI-PROJECT-16K07172, KAKENHI-PROJECT-16H06294
[Journal Article] シナプス局在から見えるPSD-95ファミリーの機能多様性2010
- Author(s)
  土井知子
- Journal Title
  
  生体の科学 61(5)
  
  Pages: 492-493
- Data Source
  KAKENHI-PROJECT-19300128
[Journal Article] PSD-95クラスタリングにおけるPDZドメインの役割2007
- Author(s)
  土井知子
- Journal Title
  
  性体の科学 58(2)
  
  Pages: 119-124
- Data Source
  KAKENHI-PROJECT-19300128
[Journal Article] PSD-95クラスタリングにおけるPDZドメインの役割2007
- Author(s)
  土井知子
- Journal Title
  
  生体の科学 58(2)
  
  Pages: 119-124
- Data Source
  KAKENHI-PROJECT-19300128
[Presentation] Endothelin Receptor-Ligand binding and conformational changes2018
- Author(s)
  Tomoko Doi
- Organizer
  International GPCR Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] エンドセリン受容体のリガンド認識機構の研究2017
- Author(s)
  土井知子
- Organizer
  薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] エンドセリン受容体の構造と機能2017
- Author(s)
  土井知子
- Organizer
  第2回日本肺高血圧・肺循環学会学術集会6月2-3日　さっぽろ芸文館
- Invited
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] Human Mutations in Endothelin A Receptor Provide an Insight into Structural rearrangement in GPCR2017
- Author(s)
  Y. Kurihara, T.Doi,C.T. Gordon, J. Amiel, H. Kurihara
- Organizer
  Molecular Pharmacology Gordon Research Conference
- Place of Presentation
  Renaissance Tuscany II Ciocco Lucca (Barga), Italy
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] エンドセリン-1によるエンドセリンB受容体の活性化機構2016
- Author(s)
  西澤知宏, 志甫谷渉, 奥田明子, 谷一寿, 藤吉好則, 濡木理 , 土井知子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] 臨床薬ボセンタンの結合したエンドセリン受容体B型の結晶構造2016
- Author(s)
  志甫谷渉、西澤知宏、奥田明子、谷一寿、藤吉好則、濡木理、土井知子
- Organizer
  第11回日本ケミカルバイオロジー学会
- Place of Presentation
  京都テルサホール（京都）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] GPCR エンドセリン A 受容体変異マウスによるヒト希少疾患の病態解明と予後の推測2016
- Author(s)
  栗原由紀子、北沢太郎、小谷理紗、Christopher T. Gordon、河村悠美子、益田将、土井知子、Jeanne Amiel、栗原裕基
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] エンドセリン受容体B型によるエンドセリン認識の構造基盤2016
- Author(s)
  志甫谷渉、西澤知宏、奥田明子、谷一寿、藤吉好則、濡木理、土井知子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] 結晶構造から明らかになった、エンドセリン-1 によるエンドセリン受容体 B 型の活性化機構2016
- Author(s)
  志甫谷渉、西澤知宏、奥田明子、谷一寿、藤吉好則、濡木理、土井知子
- Organizer
  第54回生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16K07172
[Presentation] ヒトエンドセリン受容体のX線結晶構造解析2015
- Author(s)
  志甫谷　渉、西澤　知宏、奥田　明子、谷　一寿、藤吉　好則、濡木　理、土井　知子
- Organizer
  平成27年度日本結晶学会年会
- Place of Presentation
  大阪府立大学
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26640102
[Presentation] 第33回日本神経科学大会2010
- Author(s)
  湊原圭一郎、藤吉好則、土井知子
- Organizer
  Preferable binding of a novel synaptic adhesion molecule, LRRTM2 with SAP102.
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19300128
[Presentation] The ligand-binding of PDZ domains play different roles in the synaptic clustering of PSD-95 and SAP1022009
- Author(s)
  市川昌平, 関達也, 藤吉好則, 土井知子
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜国際会議場
- Year and Date
  2009-12-17
- Data Source
  KAKENHI-PROJECT-19300128
[Presentation] 第32回日本分子生物学会年会2009
- Author(s)
  市川昌平、関達也、藤吉好則、土井知子
- Organizer
  The ligand-binding of PDZ domains play different roles in the synaptic clustering of PSD-95 and SAP102.
- Place of Presentation
  横浜国際会議
- Data Source
  KAKENHI-PROJECT-19300128
[Presentation] 第82回日本生化学会大会2009
- Author(s)
  奥田明子、西村章子、藤吉好則、土井知子
- Organizer
  Characterization of hETBR expressed in E.coli for isolation of thermo-stable mutants.
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19300128

1. ISHIKAWA Yasuyuki (90346320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TAMURA Hideki (80437516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIOSAKA Sadao (90127233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKAO Keizo (80420397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIYAKAWA Tsuyoshi (10301780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUJIYOSHI Yoshinori (80142298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. TANI Kazutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Doi Tomoko 土井 知子

DOI Tomoko 土井 知子

Research Projects

Research Products

Co-Researchers

Studies of activation mechanism of vascular-constricting hormone receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies of prerequisites for ETB agonists to accelerate anti-cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Challenge for heterodimer formation of endothelin receptors in nanodiscsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of synaptic transmission by the scaffolding protein PSD-95Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of critical residues in the extracellular and transmembrane domains of the endothelin type-B receptor for propagation of the endothelin-1 signal2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] エンドセリン受容体の初期活性化機構2017

Author(s)

Journal Title

Data Source

[Journal Article] X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thermostabilization of the human endothelin type-B receptor2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation mechanism of endothelin ETB receptor by endothelin-1.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] シナプス局在から見えるPSD-95ファミリーの機能多様性2010

Author(s)

Journal Title

Data Source

[Journal Article] PSD-95クラスタリングにおけるPDZドメインの役割2007

Author(s)

Journal Title

Data Source

[Journal Article] PSD-95クラスタリングにおけるPDZドメインの役割2007

Author(s)

Journal Title

Data Source

[Presentation] Endothelin Receptor-Ligand binding and conformational changes2018

Author(s)

Organizer

Data Source

[Presentation] エンドセリン受容体のリガンド認識機構の研究2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] エンドセリン受容体の構造と機能2017

Author(s)

Organizer

Data Source

Doi Tomoko 土井知子

DOI Tomoko 土井知子