SUNAHORI Takehiko 砂堀毅彦

… Alternative Names

SUNABORI Takehiko 砂堀毅彦

砂堀毅彦スナボリタケヒコ

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Researcher Number	00407115
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2019: 順天堂大学, 医学部, 助教 2015: 順天堂大学, 大学院医学研究科, 助教 2011 – 2015: 順天堂大学, 医学部, 助教 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / General anatomy (including Histology/Embryology) Except Principal Investigator General anatomy (including Histology/Embryology) / Pathological medical chemistry / Biological Sciences / Biological Sciences
Keywords	Principal Investigator Toll様受容体 / 海馬 / 炎症性サイトカイン / 神経細胞死 / 脳虚血 / 低酸素 / 髄鞘 / LAMTOR1 / mTOR / LAMTOR … More / MRI / Myrf / mTORC1 / Lamtor / 細胞分化 / オリゴデンドロサイト / 髄鞘形成 / 中枢神経系 / オートファジー / 脳梗塞 / ヒアルロン酸４糖 / Toll 様受容体 / ヒアルロン酸4糖 … More Except Principal Investigator オートファジー / リソソーム / ノックアウトマウス / LC3 / 胚性幹細胞 / ラパマイシン / mTORC1 / 腫瘍 / Tsc2遺伝子 / 細胞分化 / ES細胞 / モデル動物 / 結節性硬化症 / 神経軸索 / spheroid / Tom20 / DFCP1 / ユビキチン / オートファジー（選択的） / ubiquitin / Atg9A / 選択的オートファジー / NBR1 / p62 / Atg9 / カテプシンD / 軸索 / 低酸素脳虚血負荷 / DNaseII / プロセッシング / DNase II / 低酸素脳虚血付加 / 細胞死 / CAD / 海馬 / LMPCR / 心筋症 / 神経変性疾患 / リソソーム膜タンパク質 / シャペロン介在性オートファジー / 膜タンパク質 / LAMP-2 / 肥大型心筋症 / リソソーム蓄積病 / ダノン病 / RNAi / 脂肪滴 / 脂肪滴形成 / 神経再生 / 幹細胞 / 嗅球 / 細胞移動 / Slit / 脳虚血 / 神経細胞 / マウス / 発生・分化 / 脳神経疾患 / 脳・神経 / 神経科学 / 再生医学 Less

髄鞘形成と維持におけるリソソーム膜タンパク質LAMTOR1の役割Principal Investigator
- Principal Investigator
  
  砂堀毅彦
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Juntendo University
Analysis of ischemia-induced neuronal cell deathPrincipal Investigator
- Principal Investigator
  
  SUNABORI Takehiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Juntendo University
Development of novel therapeutic drugs targeting the mechanism of differentiation abnormality for tuberous sclerosis complex
- Principal Investigator
  
  Kobayashi Toshiyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Genetic study of molecular characteristic of autophagy-related proteins LC3A and LC3B
- Principal Investigator
  
  UCHIYAMA Yasuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Juntendo University
Role of lysosome-associated membrane protein LAMP-2 in autophagy
- Principal Investigator
  
  FURUTA Akiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Juntendo University
Searching for novel Dnase executing autophagic cell death.
- Principal Investigator
  
  UCHIYAMA Yasuo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Juntendo University
The effect of HA4 against hypoxic-ischemic brain injuryPrincipal Investigator
- Principal Investigator
  
  SUNABORI Takehiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Juntendo University
Proteolysis in neuronal axons and its impairment
- Principal Investigator
  
  Uchiyama Yasuo
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
正常成体脳及び侵襲脳における新生ニューロンの移動機構の解明
- Principal Investigator
  
  澤本和延
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
  Keio University

All 2019 2016 2014 2013 2012 2011 2008 Other

All Journal Article Presentation Patent

[Journal Article] Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury2019
- Author(s)
  Suzuki Chigure、Tanida Isei、Ohmuraya Masaki、Oliva Trejo Juan、Kakuta Soichiro、Sunabori Takehiko、Uchiyama Yasuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 7 Pages: 1711-1711
- DOI
  10.3390/ijms20071711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-19K08405, KAKENHI-PROJECT-18K06843
[Journal Article] Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of toll-like receptor 2 signaling pathway.2016
- Author(s)
  Sunabori T, Koike M, Asari A, Oonuki Y, Uchiyama Y
- Journal Title
  
  Am J Pathol
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111004
[Journal Article] Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of toll-like receptor 2 signaling pathway2016
- Author(s)
  Takehiko Sunabori, Masato Koike, Akira Asari, Yoji Oonuki, Yasuo Uchiyama
- Journal Title
  
  American Journal of Pathology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860139
[Journal Article] Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.2016
- Author(s)
  Mehanna, S, Suzuki, C., Shibata, M., Sunabori, T., Imanaka, T., Araki, K., Yamamura, K., Uchiyama, Y. and Ohmuraya, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 469 Issue: 3 Pages: 405-411
- DOI
  10.1016/j.bbrc.2015.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-26860139, KAKENHI-PROJECT-16K07093
[Journal Article] Purinergic signaling promotes proliferation of adult mouse subventricular zone cells2012
- Author(s)
  Suyama S, Sunabori T, Kanki H, Sawamoto K, Gachet C, Koizumi S, Okano H.
- Journal Title
  
  J Neurosci
  
  Volume: 32巻27号 Pages: 9238-9247
- Data Source
  KAKENHI-PROJECT-23790239
[Journal Article] Purified mesenchymal stem cells are an efficient source for iPS cell induction.2011
- Author(s)
  Niibe K, Kawamura Y, Araki D, Morikawa S, Miura K, Suzuki S, Shimmura S, Sunabori T, Mabuchi Y, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y.
- Journal Title
  
  PLOS One
  
  Volume: 6巻3号
- Data Source
  KAKENHI-PROJECT-23790239
[Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells2011
- Author(s)
  Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI
- Journal Title
  
  J Biol Chem
  
  Volume: 286巻15号 Pages: 13754-13764
- Data Source
  KAKENHI-PROJECT-23790239
[Journal Article] Stage/Cell cycle phase specific nestin gene expression coordinatedwith the morphological alteration of embryonic cortical neural progenitor cells2008
- Author(s)
  Sunabori, T.
- Journal Title
  
  J.Cell Sci. 121
  
  Pages: 1204-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060036
[Patent] オートファジー性細胞死抑制剤2011
- Inventor(s)
  内山安男、小池正人、砂堀毅彦、大貫洋二、三池神也
- Industrial Property Rights Holder
  内山安男、小池正人、砂堀毅彦、大貫洋二、三池神也
- Industrial Property Number
  2011-054647
- Filing Date
  2011-03-11
- Data Source
  KAKENHI-PROJECT-23790239
[Presentation] 中枢神経系の髄鞘形成におけるMyrf発現制御因子としてのLAMTOR1の役割2019
- Author(s)
  砂堀毅彦、小池正人
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06843
[Presentation] オリゴデンドロサイト分化におけるｍTORC1活性化の意義2016
- Author(s)
  砂堀毅彦、名田茂之、岡田雅人、内山安男、小池正人
- Organizer
  第121回日本解剖学会総会･全国学術集会
- Place of Presentation
  ビッグパレットふくしま
- Year and Date
  2016-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26860139
[Presentation] 中枢神経系におけるLC3A/B の役割2014
- Author(s)
  山口隼司, 砂堀毅彦, 七尾友久, 佐々木光穂, 小池正人, 内山安男
- Organizer
  第119回日本解剖学会総会
- Place of Presentation
  自治医科大学
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-23390041
[Presentation] 低酸素脳虚血障害とLC3 欠損マウス2014
- Author(s)
  山口隼司, 砂堀毅彦, 七尾友久, 佐々木光穂, 小池正人, 内山安男
- Organizer
  第19回グリアクラブ
- Place of Presentation
  新潟県湯沢
- Year and Date
  2014-03-02
- Data Source
  KAKENHI-PROJECT-23390041
[Presentation] Toll様受容体を介したオートファジー誘導機構について2013
- Author(s)
  砂堀毅彦
- Organizer
  第118回日本解剖学会総会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-23790239
[Presentation] Toll様受容体を介したオートファジー誘導機構について2013
- Author(s)
  砂堀毅彦
- Organizer
  第１１８回日本解剖学会総会ポスター発表
- Place of Presentation
  サンポートホール高松・かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-23659102
[Presentation] Toll様受容体を介したオートファジー誘導機構について2013
- Author(s)
  砂堀毅彦
- Organizer
  第１１８回日本解剖学会総会ポスター発表
- Place of Presentation
  サンポートホール高松・かがわ国際会議場
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PLANNED-23111004
[Presentation] Toll様受容体を介したオートファジー誘導機構について2013
- Author(s)
  砂堀毅彦
- Organizer
  第１１８回日本解剖学会総会ポスター発表
- Place of Presentation
  サンポートホール高松・かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-23390041
[Presentation] Inactivation of Toll-like receptors 2/4 by hyaluronan tetrasaccharide suppresses hypoxic-ischemic injury in hippocampal pyramidal neurons.2012
- Author(s)
  Sunabori T
- Organizer
  Hershey Conference
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-23790239
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse after hypoxic-ischemic injury2012
- Author(s)
  Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学甲府キャンパス
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-23390041
[Presentation] ヒアルロン酸4糖は低酸素/脳虚血負荷依存性にToll様受容体2/4の活性化を抑制することで海馬錐体細胞に神経保護効果を示す2012
- Author(s)
  砂堀毅彦
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790239
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse after hypoxic-ischemic injury2012
- Author(s)
  Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学甲府キャンパス
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PLANNED-23111004
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse after hypoxic-ischemic injury2012
- Author(s)
  Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学甲府キャンパス
- Data Source
  KAKENHI-PROJECT-23659102
[Presentation] 虚血生侵襲に対するヒアルロン酸４糖の神経細胞保護効果の検討2011
- Author(s)
  砂堀毅彦、小池正人、内山安男
- Organizer
  第３４回日本神経科学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23659102
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury2011
- Author(s)
  Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
- Organizer
  41st Annual Meeting Society for Neuroscience
- Place of Presentation
  ワシントン・コンベンション・センター
- Data Source
  KAKENHI-PROJECT-23659102
[Presentation] 虚血生侵襲に対するヒアルロン酸4糖の神経細胞保護効果の検討2011
- Author(s)
  砂堀毅彦、小池正人、内山安男
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23390041
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury2011
- Author(s)
  Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
- Organizer
  41 st Annual Meeting Society for Neuroscience
- Place of Presentation
  ワシントン・コンベンション・センター
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23390041
[Presentation] 虚血生侵襲に対するヒアルロン酸4糖の神経細胞保護効果の検討2011
- Author(s)
  砂堀毅彦、小池正人、内山安男
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横兵
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PLANNED-23111004
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury2011
- Author(s)
  Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
- Organizer
  41st Annual Meeting Society for Neuroscience
- Place of Presentation
  ワシントン・コンベンション・センター
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PLANNED-23111004
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury
- Author(s)
  Takehiko Sunabori
- Organizer
  第４２回北米神経科学学会　Neuro2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23790239
[Presentation] オリゴデンドロサイト分化におけるmTORC1活性化の意義
- Author(s)
  砂堀毅彦
- Organizer
  第20回グリアクラブ
- Place of Presentation
  函館
- Year and Date
  2015-01-26 – 2015-01-28
- Data Source
  KAKENHI-PROJECT-26860139
[Presentation] Toll like receptors control neuronal cell death via regulating the activation and production of nitric oxide in microglia cells of cathepsin D-deficient mice
- Author(s)
  砂堀毅彦
- Organizer
  第120回日本解剖学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26860139
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury
- Author(s)
  砂堀毅彦
- Organizer
  第１１７回日本解剖学会総会
- Place of Presentation
  山梨大学
- Data Source
  KAKENHI-PROJECT-23790239
[Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury
- Author(s)
  砂堀毅彦
- Organizer
  第３４回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23790239

1. KOIKE Masato (80347210)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
2. SASAKI Mitsuho (20432536)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. SUZUKI Chigure (40536629)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. UCHIYAMA Yasuo (10049091)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
5. SHIBATA Masahiro (10343253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FURUTA Akiko (50229118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kobayashi Toshiyuki (40260070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TADA Norihiro (50338315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 澤本和延 (90282350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 廣田ゆき (00453548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金子奈穂子 (20464571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHIKAWA Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUZUKI Hiromu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. OHMURAYA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 鈴木登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 鈴木貞夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 鈴木操

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山村研一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 荒木喜美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SUNAHORI Takehiko 砂堀 毅彦

SUNABORI Takehiko 砂堀 毅彦

砂堀 毅彦 スナボリ タケヒコ

Research Projects

Research Products

Co-Researchers

髄鞘形成と維持におけるリソソーム膜タンパク質LAMTOR1の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of ischemia-induced neuronal cell deathPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic drugs targeting the mechanism of differentiation abnormality for tuberous sclerosis complex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic study of molecular characteristic of autophagy-related proteins LC3A and LC3B

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of lysosome-associated membrane protein LAMP-2 in autophagy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Searching for novel Dnase executing autophagic cell death.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of HA4 against hypoxic-ischemic brain injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteolysis in neuronal axons and its impairment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

正常成体脳及び侵襲脳における新生ニューロンの移動機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of toll-like receptor 2 signaling pathway.2016

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of toll-like receptor 2 signaling pathway2016

Author(s)

Journal Title

Data Source

[Journal Article] Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purinergic signaling promotes proliferation of adult mouse subventricular zone cells2012

Author(s)

SUNAHORI Takehiko 砂堀毅彦

SUNABORI Takehiko 砂堀毅彦

砂堀毅彦スナボリタケヒコ