Saitoh Takashi 齊藤貴士

… Alternative Names

SAITOH Takashi 斉藤貴士

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Researcher Number	00432914
Other IDs
Affiliation (Current)	2025: 北海道科学大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 北海道科学大学, 薬学部, 准教授 2013: 九州大学, 生体防御医学研究所, 助教 2012: 北海道大学, 大学院・薬学研究院, 技術職員 2012: 北海道大学, 薬学研究科(研究院), 技術職員 2010 – 2011: 九州大学, 生体防御医学研究所, 特任助教 2008 – 2009: Kyushu University, デジタルメディシン・イニシアティブ, 助教 2008: 九州大学, デジタルメディシンイニシアティブ, 助教
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 43040:Biophysics-related / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Basic Section 43030:Functional biochemistry-related / Complex systems / Biological Sciences
Keywords	Principal Investigator 相互作用 / 構造生物学 / X線結晶構造解析 / NMR / タンパク質 / アピコプラスト / マラリア原虫 / ミトコンドリア / 蛋白質 / 分子認識及び相互作用 … More / 分子認識 / Tic22 / 等温滴定型熱量計 / インシリコスクリーニング / バイオレイヤ干渉法 / タンパク質間相互作用 / マラリア / 蛋白質間相互作用 / NMRスペクトル解析 / 蛋白質複合体 / Ｘ線結晶構造解析 / ＮＭＲ / タンパク相互作用 … More Except Principal Investigator 薬剤耐性メカニズム / フェレドキシン / マラリア原虫 / 複合体安定化技術 / 分子認識 / Tom20 / プレ配列 / ミトコンドリア / 細胞内輸送 / タンパク質 / アルテミシニン / 薬剤耐性 / ジスルフィド結合 / 融合タンパク質 / 結晶コンタクト効果 / 複合体 / ＮＭＲ解析 / Ｘ線結晶解析 / オリゴ糖転移酵素 / ペプチドライブラリ / 構造生物学 / タンパク質輸送 / X線結晶構造 / 緩和時間解析 / NMR / X線結晶解析 / SS結合 / プレ配列受容体 / 分子内ジスルフィド結合 / リガンド係留技術 / 標的シグナル / ,分子認識 Less

マラリア原虫のフェレドキシンの変異が薬剤耐性をもたらす機序の解明
- Principal Investigator
  
  木股洋子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Yamaguchi University
マラリア原虫が持つ植物由来Tic22タンパク質によるペプチド鎖認識機構の解明Principal Investigator
- Principal Investigator
  
  齊藤貴士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Hokkaido University of Science
Elucidation of the role of ferredoxin mutations in artemisinin resistance in malaria parasites
- Principal Investigator
  
  Kimata Yoko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Yamaguchi University
Mechanisms of protein transport into the quadruplex membrane organelle of Plasmodium falciparumPrincipal Investigator
- Principal Investigator
  
  Saitoh Takashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Hokkaido University of Science
Investigation of the interaction mechanism for multiple presequences by mitochondrial Tom20Principal Investigator
- Principal Investigator
  
  SAITOH Takashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
  Kyushu University
Development of experimental techniques for the investigation of transient molecular protein complexes
- Principal Investigator
  
  KOHDA Daisuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyushu University
Recognition of presequences of mitochondrial precursor proteins using dynamic equilibriumPrincipal Investigator
- Principal Investigator
  
  SAITOH Takashi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyushu University
soft interaction for the recognition of mitochondrial targeting signal
- Principal Investigator
  
  KOHDA Daisuke
- Project Period (FY)
  2003 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University

All 2021 2020 2013 2011 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] C-terminal aromatic residue of Plasmodium ferredoxin important for the interaction with ferredoxin: NADP(H) oxidoreductase: possible involvement for artemisinin resistance of human malaria parasites2020
- Author(s)
  Kimata-Ariga Yoko、Sakamoto Asako、Kamatani Miho、Saitoh Takashi、Hase Toshiharu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 168 Issue: 4 Pages: 427-434
- DOI
  10.1093/jb/mvaa060
- NAID
  40022393407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Energetics of the presequence-binding poses in mitochondrial protein import through Tom202013
- Author(s)
  Komuro, Y., Miyashita, N., Mori, T., Muneyuki, E., Saitoh, T., Kohda, D., Sugita, Y.
- Journal Title
  
  J Phys Chem B
  
  Volume: 117 Pages: 2864-2871
- Data Source
  KAKENHI-PLANNED-21121003
[Journal Article] Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance2013
- Author(s)
  Nyirenda, J., Matsumoto, S., Saitoh, T., Maita, N., Noda, N. N., Inagaki, F., Kohda, D.
- Journal Title
  
  Structure
  
  Volume: 21 Pages: 32-41
- Data Source
  KAKENHI-PLANNED-21121003
[Journal Article] Crystallographic snapshots of Tom20-mitochondrial presequence interactions with disulfide-stabilized peptides2011
- Author(s)
  Saitoh, T., Igura, M., Miyazaki, Y., Ose, T., Maita, N., Kohda, D.
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 5487-5496
- Data Source
  KAKENHI-PLANNED-21121003
[Journal Article] 共有結合を用いた平衡シフトによる過渡的タンパク質複合体からの構造情報の取得2011
- Author(s)
  神田大輔,齊藤貴士
- Journal Title
  
  生化学
  
  Volume: 第83巻第10号 Pages: 902-911
- NAID
  10029850124
- Data Source
  KAKENHI-PLANNED-21121003
[Journal Article] ミトコンドリアのプレ配列は動的平衡メカニズムにより認識される2009
- Author(s)
  齊藤貴士, 尾瀬農之, 神田大輔
- Journal Title
  
  生物物理 vol.49(2009),No.5
- NAID
  10025975892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770087
[Journal Article] ミトコンドリアのプレ配列は動的平衡メカニズムにより認識される2009
- Author(s)
  齊藤貴士・尾瀬農之・神田大輔
- Journal Title
  
  生物物理 49
  
  Pages: 242-243
- NAID
  10025975892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770087
[Journal Article] Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states2007
- Author(s)
  Saitoh T, Igura M, Obita T, Ose T, Kojima R, Maenaka K, Endo T, Kohda D
- Journal Title
  
  EMBO J 26
  
  Pages: 4777-4787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083205
[Journal Article] Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states2007
- Author(s)
  T., Saitoh, et. al.
- Journal Title
  
  EMBO Journal 26
  
  Pages: 4777-4787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083205
[Presentation] アルテミシニン耐性に関与するマラリア原虫フェレドキシン変異体の機能解析2021
- Author(s)
  木股洋子、森久鈴菜、齊藤貴士、新小田里奈、西水禎朗
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06557
[Presentation] マラリア原虫フェレドキシンとフェレドキシン-NADP(H)酸化還元酵素との結合に重要な芳香族アミノ酸残基間相互作用：アルテミシニン耐性との関連性2020
- Author(s)
  木股洋子、坂本麻沙子、鎌谷美穂、森久鈴菜、齊藤貴士
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06557
[Presentation] ミトコンドリアTom20とプレ配列の相互作用解析におけるジスルフィド結合の利用2011
- Author(s)
  齊藤貴士、神田大輔
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪ホテル阪急エキスポパーク
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-22770104
[Presentation] ミトコンドリアTom20とプレ配列の相互作用解析におけるジスルフィド結合の利用2011
- Author(s)
  齊藤貴士、神田大輔
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-22770104
[Presentation] 共有結合を用いたTom20タンパク質複合体におけるプレ配列動的認識の考察2011
- Author(s)
  泉桂星、齊藤貴士、寺沢宏明、神田大輔
- Organizer
  2011年日本生物物理学会九州支部例会
- Place of Presentation
  福岡のがみプレジデントホテル
- Year and Date
  2011-12-04
- Data Source
  KAKENHI-PROJECT-22770104
[Presentation] Stabilization and Structure Analysis of Mitochondrial Tom20-Presequence Complexes2011
- Author(s)
  T Saitoh, K Izumi, Y Miyazaki, D Kohda
- Organizer
  The 7th Global COE International Symposium, the 6th Young Investigators Forum
- Place of Presentation
  Bintan Island, Indonesia
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PLANNED-21121003
[Presentation] Tom20とプレ配列ペプチドの複合体の安定化と結晶化2010
- Author(s)
  齊藤貴士
- Organizer
  第10回蛋白質科学会年会
- Place of Presentation
  札幌
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22770104
[Presentation] ミトコンドリアTom20とプレ配列ペプチドの複合体の安定化と結晶化2010
- Author(s)
  齊藤貴士、神田大輔
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌札幌コンベンションセンター
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22770104
[Presentation] 構造生物学から見たミトコンドリアTom20による前駆蛋白質のプレ配列認識2009
- Author(s)
  齊藤貴士・宮崎佑介、尾瀬農之、神田大輔
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  態本
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20770087
[Presentation] 構造生物学から見たミトコンドリアTom20による前駆蛋白質のプレ配列認識2009
- Author(s)
  齊藤貴士, 宮崎佑介, 尾瀬農之, 神田大輔
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20770087
[Presentation] Relaxation Analysis of the Tom20-Bound states of a Mitochondrial Presequence.2008
- Author(s)
  Takashi Saitoh, Daisuke Kohda
- Organizer
  XXIIrd ICMRBS
- Place of Presentation
  USA
- Year and Date
  2008-08-25
- Data Source
  KAKENHI-PROJECT-20770087
[Presentation] 複数の結合様式を介したミトコンドリアTom20によるプレ配列の認識機構2008
- Author(s)
  齊藤貴士、井倉真由美、尾瀬農之、前中勝実、神田大輔
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-20770087
[Presentation] Relaxation analysis of the Tom20-bound states of a mitochondrial presequence2008
- Author(s)
  Takashi Saitoh
- Organizer
  International Conference on Magnetic Resonance in Biological Systems (XXIII ICMRBS)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-15083205
[Presentation] 「複数の結合様式を介したミトコンドリアTom20によるプレ配列の認識機構」(口頭発,若手奨励賞シンポジウム)2008
- Author(s)
  斉藤貴士
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-15083205
[Presentation] Relaxation Analysis of the Tom20-Bound states of a Mitochondorial Presequence2008
- Author(s)
  Saitoh, Tkakshi
- Organizer
  XXIII International Conference on Magnetic Resonance in Biological System
- Place of Presentation
  San-Diego
- Year and Date
  2008-08-25
- Data Source
  KAKENHI-PROJECT-20770087
[Presentation] ミトコンドリアTom20によるプレ配列の動的認識機構:緩和解析からのアプローチ(ワークショップ口演)2007
- Author(s)
  齊藤貴士
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-15083205
[Presentation] Dynamic recognition of mitochondrial presequences by Tom202006
- Author(s)
  Takashi Saitoh
- Organizer
  The 2nd Sapporo Conference 2006; New Trend in Structural Biology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-15083205

1. Kimata Yoko (60255429)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. KOHDA Daisuke (80186618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 小崎紳一 (40280581)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MAENAKA Katsumi (10322752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SHIMADA Atsushi (70391977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MAYANAGI Kouta (50418571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IGURA Mayumi (60529965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 湯山育子 (80565995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Saitoh Takashi 齊藤 貴士

SAITOH Takashi 斉藤 貴士

Research Projects

Research Products

Co-Researchers

マラリア原虫のフェレドキシンの変異が薬剤耐性をもたらす機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マラリア原虫が持つ植物由来Tic22タンパク質によるペプチド鎖認識機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of ferredoxin mutations in artemisinin resistance in malaria parasites

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of protein transport into the quadruplex membrane organelle of Plasmodium falciparumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the interaction mechanism for multiple presequences by mitochondrial Tom20Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of experimental techniques for the investigation of transient molecular protein complexes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Recognition of presequences of mitochondrial precursor proteins using dynamic equilibriumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

soft interaction for the recognition of mitochondrial targeting signal

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] C-terminal aromatic residue of Plasmodium ferredoxin important for the interaction with ferredoxin: NADP(H) oxidoreductase: possible involvement for artemisinin resistance of human malaria parasites2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Energetics of the presequence-binding poses in mitochondrial protein import through Tom202013

Author(s)

Journal Title

Data Source

[Journal Article] Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance2013

Author(s)

Journal Title

Data Source

[Journal Article] Crystallographic snapshots of Tom20-mitochondrial presequence interactions with disulfide-stabilized peptides2011

Author(s)

Journal Title

Data Source

[Journal Article] 共有結合を用いた平衡シフトによる過渡的タンパク質複合体からの構造情報の取得2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] ミトコンドリアのプレ配列は動的平衡メカニズムにより認識される2009

Author(s)

Journal Title

NAID

Saitoh Takashi 齊藤貴士

SAITOH Takashi 斉藤貴士