Onoyama Ichiro 小野山一郎

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ONOYAMA Ichiro 小野山一郎

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Researcher Number	00444802
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2023: 九州大学, 大学病院, 講師 2020 – 2022: 九州大学, 大学病院, 助教 2010: Kyushu University, 医学研究院・周産期小児医療学講座, 客員助教 2010: 九州大学, 大学病院, 客員助教 2010: 九州大学, 大学院・医学研究院, 客員助教 2009: Kyushu University, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology
Keywords	Principal Investigator 卵巣癌 / 5hmC / DNA脱メチル化 / 卵巣漿液性癌 / エピゲノム / Fbxw7 / 子宮筋肉腫 / 婦人科腫瘍学 Except Principal Investigator プロテオーム / FBXW7 / 子宮肉腫

卵巣癌におけるゲノムワイドな5hmC解析と臨床病理学的因子に関する研究Principal Investigator
- Principal Investigator
  
  小野山一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyushu University
5-hydroxymethylcytosine and clinicopathological features in ovarian serous carcinomaPrincipal Investigator
- Principal Investigator
  
  Onoyama Ichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyushu University
Research on diagnosis and standard therapy of the uterine sarcoma
- Principal Investigator
  
  OKUGAWA Kaoru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Functional analysis of Fbxw7 in uterine myometriuma and uterine sarcomaPrincipal Investigator
- Principal Investigator
  
  ONOYAMA Ichiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 子宮肉腫研究の最前線2023
- Author(s)
  小野山一郎、加藤聖子
- Total Pages
  6
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20K09646
[Book] 産科と婦人科第78巻1号、特集婦人科がんのMolecular Biology、アポトーシス
- Author(s)
  小野山一郎、小林裕明
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer2023
- Author(s)
  Ichiro Onoyama, Minoru Kawakami, Kazuhisa Hachisuga, Shoji Maenohara, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Kazuo Asanoma, Hideaki Yahata, Yuya Kitamura, Ryuichi Sakamoto, Daisuke Kiyozawa and Kiyoko Kato
- Journal Title
  
  Reports
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09646
[Journal Article] YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer2021
- Author(s)
  Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Itakura A, Takeda S, Kato K
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 4220-4220
- DOI
  10.1038/s41598-021-83200-5
- NAID
  120007044568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21540, KAKENHI-PROJECT-18KK0433, KAKENHI-PROJECT-18H02678, KAKENHI-PROJECT-19H03800, KAKENHI-PROJECT-20K09646, KAKENHI-PROJECT-21K09519, KAKENHI-PROJECT-21K09520
[Journal Article] Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells2021
- Author(s)
  Yoshida Sachiko、Asanoma Kazuo、Yagi Hiroshi、Onoyama Ichiro、Hori Emiko、Matsumura Yumiko、Okugawa Kaoru、Yahata Hideaki、Kato Kiyoko
- Journal Title
  
  BMC Cancer
  
  Volume: 21 Issue: 1 Pages: 1-12
- DOI
  10.1186/s12885-021-07875-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03800, KAKENHI-PROJECT-20K09646, KAKENHI-PROJECT-21K09519, KAKENHI-PROJECT-21K09520
[Journal Article] Loss of Fbxw7 impairs development of and induces heterogeneous tumor formation in the mouse mammary gland2020
- Author(s)
  Onoyama Ichiro、Nakayama Shogo、Shimizu Hideyuki、Nakayama Keiichi I.
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 24 Pages: 5515-5530
- DOI
  10.1158/0008-5472.can-20-0271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09646, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-19J10033, KAKENHI-PROJECT-19K20403
[Journal Article] Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia2020
- Author(s)
  Kato Masaya、Onoyama Ichiro、Kawakami Minoru、Yoshida Sachiko、Kawamura Keiko、Kodama Keisuke、Hori Emiko、Cui Lin、Matsumura Yumiko、Yagi Hiroshi、Asanoma Kazuo、Yahata Hideaki、Itakura Atsuo、Takeda Satoru、Kato Kiyoko
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 11 Pages: 0241482-0241482
- DOI
  10.1371/journal.pone.0241482
- NAID
  120007044541
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09646, KAKENHI-PROJECT-19H03517, KAKENHI-PROJECT-19H03800
[Journal Article] Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.2011
- Author(s)
  Matsumoto A, Tateishi Y, Onoyama I, Okita Y, Nakayama K, Nakayama KI.
- Journal Title
  
  Cancer Sci. 102(4)
  
  Pages: 749-755
- NAID
  10029292153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells.2011
- Author(s)
  Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI.
- Journal Title
  
  J Biol Chem. Feb 24.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver2011
- Author(s)
  Onoyama I, et al
- Journal Title
  
  J.Clin.Invest.
  
  Volume: 121(1) Pages: 342-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression.2011
- Author(s)
  Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T.
- Journal Title
  
  Blood. 117(8)
  
  Pages: 2373-2377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.2011
- Author(s)
  Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.
- Journal Title
  
  Nature. 471(7336)
  
  Pages: 104-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.2011
- Author(s)
  Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI
- Journal Title
  
  J Clin Invest. 121(1)
  
  Pages: 342-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : Clinical significance.2010
- Author(s)
  Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M.
- Journal Title
  
  Int J Cancer. 126(8)
  
  Pages: 1828-1837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts.2010
- Author(s)
  Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K.
- Journal Title
  
  Oncogene. 29(12)
  
  Pages: 1798-1809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Journal Article] p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases.2009
- Author(s)
  Yokobori T, Mimori K, Iwatsuki M, Ishii H, Onoyama I, Fukagawa T, Kuwano H, Nakayama KI, Mori M.
- Journal Title
  
  Cancer Res. 69(9)
  
  Pages: 3788-3794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791560
[Presentation] Initial epigenetic alteration induced by aberrant activation of RAS-MAPK signaling in non-transformed cells.2024
- Author(s)
  Ichiro Onoyama, Hiroshi Yagi, Kazuo Asanoma, Minoru Kawakami, Kazuhisa Hachisuga, Hiroshi Tomonobe, Shoji Maenohara, Keisuke Kodama, Masafumi Yasunaga, Hideaki Yahata, Kiyoko Kato
- Organizer
  第76回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-23K08800
[Presentation] Epigenetic characterization of ovarian serous carcinoma with lymph-node metastasis by 5-hydroxymethylcytosine sequencing2022
- Author(s)
  Ichiro Onoyama, Masaya Kato, Minoru Kawakami, Shoji Maenohara, Keisuke Kodama, Hiroshi Yagi, Kazuo Asanoma, Kiyoko Kato
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09646
[Presentation] 5-hydroxymethylcytosine sequencing revealed epigenetic characteristics in ovarian serous carcinoma with lymph-node metastasis.2022
- Author(s)
  Ichiro Onoyama, Masaya Kato, Minoru Kawakami, Kazuhisa Hachisuga, Nobuko Yasutake, Keisuke Kodama, Hiroshi Yagi, Tatsuhiro Ohgami, Masafumi Yasunaga, Kaoru Okugawa, Kazuo Asanoma, Hideaki Yahata, Emiko Hori, Kiyoko Kato
- Organizer
  第64回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09646
[Presentation] 子宮体癌に対するペンブロリズマブ治療中にACTH欠損症を起こした2例2022
- Author(s)
  小野山一郎、川上穣、蜂須賀一寿、前之原章司、小玉敬亮、八木裕史、安永昌史、大神達寛、奥川馨、淺野間和夫、矢幡秀昭、北村雄哉、坂本竜一、加藤聖子
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09646
[Presentation] Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia2021
- Author(s)
  Ichiro Onoyama, Masaya Kato, Minoru Kawakami, Keiko Kawamura, Hiroshi Yagi , Kazuo Asanoma, Kiyoko Kato
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09646
[Presentation] Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia2021
- Author(s)
  Ichiro Onoyama, Masaya Kato, Minoru Kawakami, Sachiko Yoshida, Keiko Kawamura, Hiroshi Yagi , Kazuo Asanoma, Hideaki Yahata, Kiyoko Kato
- Organizer
  第73回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09646
[Presentation] 5-ヒドロキシメチルシトシン量の低下は子宮頸部上皮内癌の進展に関係する2021
- Author(s)
  川上穣、小野山一郎、加藤雅也、友延寛、安武伸子、吉田祥子、小玉敬亮、八木裕史、安永昌史、大神達寛、奥川馨、矢幡秀昭、加藤聖子
- Organizer
  第63回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09646
[Presentation] ユビキチンリガーゼFbxw7の上皮性卵巣腫瘍における発現解析2010
- Author(s)
  北出尚子、小野山一郎、小林裕明、和氣徳夫
- Organizer
  第62回日本産科婦人科学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21791560
[Presentation] ユビキチンリガーゼFbxw7による細胞周期制御2009
- Author(s)
  小野山一郎、恒松良祐、小林裕明、中山敬一、和氣徳夫
- Organizer
  細胞分化制御と発がん抑制機構第8回日本婦人科がん分子標的研究会
- Place of Presentation
  福岡
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21791560
[Presentation] ユビキチンリガーゼFbxw7によるG0期維持機構とその破綻による発がん2009
- Author(s)
  小野山一郎
- Organizer
  第14回生殖医学フォーラム
- Place of Presentation
  大津
- Year and Date
  2009-09-21
- Data Source
  KAKENHI-PROJECT-21791560
[Presentation] ユビキチンリガーゼFbxw7による細胞周期制御と細胞分化制2009
- Author(s)
  小野山一郎、恒松良祐、小林裕明、和氣徳夫
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-21791560
[Presentation] ユビキチンリガーゼFbxw7による細胞周期制御と細胞分化制御2009
- Author(s)
  小野山一郎、恒松良祐、小林裕明、中山敬一、和氣徳夫
- Organizer
  第14回日本病態プロテアーゼ学会
- Place of Presentation
  大阪
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-21791560

1. OKUGAWA Kaoru (90452789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. KANEKI Eisuke (90423508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KAKU Tsunehisa (60185717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SONODA Kenzou (30294929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KOBAYASHI Hiroaki (70260700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 椨康一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田賀哲也

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# of Collaborated Products: 1 results
8. 加藤聖子

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# of Collaborated Products: 1 results

Onoyama Ichiro 小野山 一郎

ONOYAMA Ichiro 小野山 一郎

Research Projects

Research Products

Co-Researchers

卵巣癌におけるゲノムワイドな5hmC解析と臨床病理学的因子に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

5-hydroxymethylcytosine and clinicopathological features in ovarian serous carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on diagnosis and standard therapy of the uterine sarcoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of Fbxw7 in uterine myometriuma and uterine sarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 子宮肉腫研究の最前線2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 産科と婦人科 第78巻1号、特集婦人科がんのMolecular Biology、アポトーシス

Author(s)

Publisher

Data Source

[Journal Article] Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer2023

Author(s)

Journal Title

Data Source

[Journal Article] YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of Fbxw7 impairs development of and induces heterogeneous tumor formation in the mouse mammary gland2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells.2011

Author(s)

Journal Title

Data Source

[Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver2011

Author(s)

Journal Title

Data Source

[Journal Article] Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression.2011

Author(s)

Journal Title

Onoyama Ichiro 小野山一郎

ONOYAMA Ichiro 小野山一郎

[Book] 産科と婦人科第78巻1号、特集婦人科がんのMolecular Biology、アポトーシス