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Takahashi Miho  高橋 美帆

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TAKAHASHI Miho  高橋 美帆

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Researcher Number 00446569
Other IDs
Affiliation (Current) 2025: 同志社大学, 生命医科学部, 助教
Affiliation (based on the past Project Information) *help 2015 – 2023: 同志社大学, 生命医科学部, 助教
2008 – 2012: Doshisha University, 生命医科学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Bacteriology (including Mycology) / Environmental pharmacy
Except Principal Investigator
Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
感染症 / エクソソーム / 小胞輸送 / 細胞内小胞輸送 / 志賀毒素 / 志賀毒素2(Stx2) / 志賀毒素2 / Shia toxin (Stx) / 基質ペプチドアレイ / キナーゼ … More / ペプチドアレイ / エキソソーム / プロテインキナーゼ / エキソソーム(エクソソーム) / Stx阻害ペプチド / キナーゼ基質アレイ / 腸管出血性大腸菌 / ペプチドライブラリー / 阻害剤 / ペプチド / 病原性 / 感染症学 / 微生物 … More
Except Principal Investigator
炎症マーカー / サイトカイン / 消化管粘膜 / 必須アミノ酸 / 抗癌剤 / LAT / 炎症 / 粘膜 / アミノ酸トランスポーター / アミノ酸 Less
  • Research Projects

    (6 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (7 People)
  •  Molecular mechanism underlying the production of exosome-associated Shiga toxin 2a, which causes severe toxicity in micePrincipal Investigator

    • Principal Investigator
      高橋 美帆
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Doshisha University
  •  Potential of amino acid transporter as a marker for inflammation of intestinal mucosa

    • Principal Investigator
      Kawashima Rei
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kitasato University
  •  Development of a new therapeutic agent that inhibits the production of exosome-associated Shiga toxin 2Principal Investigator

    • Principal Investigator
      Takahashi Miho
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Doshisha University
  •  Development of a novel Shiga toxin inhibitor that targeting of intracellular transport of the toxinPrincipal Investigator

    • Principal Investigator
      Takahashi Miho
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including mycology)
    • Research Institution
      Doshisha University
  •  Development peptide-based compounds which bind to the specific receptor-binding region of Shiga toxin B subunitPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Miho
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Doshisha University
  •  An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin.Principal Investigator

    • Principal Investigator
      TAKAHASHI Miho
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Doshisha University

All 2024 2021 2018 2016 2015 2013 2012 2011 2010 2009

All Journal Article Presentation Patent

  • [Journal Article] Tailored multivalent peptide targeting the B-subunit pentamer of cholera toxin inhibits its intestinal toxicity by inducing aberrant transport of the toxin in cells2024

    • Author(s)
      Miho Watanabe-Takahashi, Kahori Kumoi, Hiroshi Yamamoto, Eiko Shimizu, Jun Motoyama, Takashi Hamabata, Kiyotaka Nishikawa
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 716 Pages: 149991-149991

    • DOI

      10.1016/j.bbrc.2024.149991

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K06106
  • [Journal Article] A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid b by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit2021

    • Author(s)
      Waka Sato, Miho Watanabe-Takahashi, Takashi Hamabata, Koichi Furukawa, Satoru Funamoto, Kiyotaka Nishikawa
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 557 Pages: 247-253

    • DOI

      10.1016/j.bbrc.2021.04.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07128, KAKENHI-PROJECT-18H02628, KAKENHI-PROJECT-19K22518
  • [Journal Article] Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin2021

    • Author(s)
      Miho Watanabe-Takahashi, Masakazu Tamada, Miki Senda, Masahiro Hibino, Eiko Shimizu, Akiko Okuta, Atsuo Miyazawa, Toshiya Senda, Kiyotaka Nishikawa
    • Journal Title

      Communications biology

      Volume: 538 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s42003-021-02068-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07128
  • [Journal Article] Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice2018

    • Author(s)
      Watanabe-Takahashi, M., Yamasaki, S., Murata, M., Kano, F., Motoyama, J., Yamate, J., Omi, J., Sato, W., Ukai, H., Shimasaki, K., Ikegawa, M., Tamura-Nakano, M., Yanoshita, R., Nishino, Y., Miyazawa, A., Natori, Y., Toyama-Sorimachi, N., Nishikawa, N.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 10776-10776

    • DOI

      10.1038/s41598-018-29128-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07379, KAKENHI-PROJECT-18K07128, KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-17H05870, KAKENHI-INTERNATIONAL-15K21719, KAKENHI-PLANNED-15H05903
  • [Journal Article] Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy2018

    • Author(s)
      Shimasaki K, Watanabe-Takahashi M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, Nishikawa K.
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 1 Pages: 22-34

    • DOI

      10.1111/gtc.12544

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07044, KAKENHI-PLANNED-15H05930, KAKENHI-PROJECT-17H03805, KAKENHI-PROJECT-15K08480, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H03821
  • [Journal Article] Affinity-based screening of tetravalent peptides identifies subtype-selective neutralizers of Shiga toxin 2d, a highly virulent subtype, by targeting a unique amino acids involved in its receptor recognition.2016

    • Author(s)
      Mitsui T., Watanabe-Takahashi M., Shimizu E., Zhang B., Funamoto S., Yamasaki S., Nishikawa K.
    • Journal Title

      Infection and Immunity

      Volume: 84 Pages: 2653-2661

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08480
  • [Journal Article] Identification of a wide range of motifs inhibitory to Shiga toxin by affinity-driven screening of customized divalent peptides synthesized on a membrane2015

    • Author(s)
      1) Kato M., Watanabe-Takahashi M., Shimizu E., and Nishikawa K.
    • Journal Title

      Appl. Environ. Microbiol.

      Volume: 81 Issue: 3 Pages: 1092-1100

    • DOI

      10.1128/aem.03517-14

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390035, KAKENHI-PROJECT-15K08480
  • [Journal Article] Identification of a peptide-based neutralizer that potently inhibits both Shiga toxins 1 and 2 by targeting specific receptor- binding regions2013

    • Author(s)
      Watanabe-Takahashi M., Tsustuki K., Takenaka Y., Kita E., Nishikawa K
    • Journal Title

      Infection and Immunity

      Volume: 81(掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Journal Article] Identification of a peptide-based neutralizer that potently inhibits both Shiga toxins 1 and 2 by targeting specific receptor- binding regions.2013

    • Author(s)
      Watanabe-Takahashi M., Tsustuki K. (contributed equally to this article)
    • Journal Title

      Infection and Immunity

      Volume: 81 Issue: 6 Pages: 2133-2138

    • DOI

      10.1128/iai.01256-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790418, KAKENHI-PROJECT-23590515, KAKENHI-PROJECT-24390035
  • [Journal Article] An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin2010

    • Author(s)
      Watanabe-Takahashi M., Sato T., Dohi T., Noguchi N., Kano F., Murata M., Hamabata T., Natori Y., Nishikawa K.
    • Journal Title

      Infection and Immunity 78

      Pages: 177-183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Journal Article] An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin.2010

    • Author(s)
      Watanabe-Takahashi M., Sato T., Dohi T., Noguchi N., Kano F., Murata M., Hamabata T,. Natori Y., Nishikawa K.
    • Journal Title

      Infection and Immunity 78

      Pages: 177-183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Journal Article] An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin2010

    • Author(s)
      Watanabe-Takahashi M., Sato T., Dohi T., Noguchi N., Kano F., Murata M., Hamabata T,. Natori Y., and Nishikawa K
    • Journal Title

      Infection and Immunity

      Volume: 78 Pages: 177-183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Journal Article] Yip1A regulates the COPI - independent retrograde transport from the Golgi complex to the ER2009

    • Author(s)
      Kano F, Yamauchi S, Yoshida Y, Watanabe-Takahashi M, Nishikawa K, Nakamura N, Murata M.
    • Journal Title

      Journal of Cell Science 122

      Pages: 2218-2227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Journal Article] YiplA regulates the COPI-independent retrograde transport from the Golgi apparatus to the endoplasmic reticulum2009

    • Author(s)
      Kano F., Yamauchi S., Yoshida Y., Watanabe-Takahashi M., Nishikawa K., Nakamura N., Murata M
    • Journal Title

      Journal of Cell Science (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Journal Article] Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER2009

    • Author(s)
      Kano F, Yamauchi S, Yoshida Y, Watanabe-Takahashi M, Nishikawa K, Nakamura N, Murata M
    • Journal Title

      Journal of Cell Science

      Volume: 122 Pages: 2218-2227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Journal Article] Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER2009

    • Author(s)
      Kano F, Yamauchi S, Yoshida Y, Watanabe-Takahashi M, Nishikawa K, Nakamura N, Murata M.
    • Journal Title

      Journal of Cell Science 122

      Pages: 2218-2227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Patent] ヘマグルチニン結合ペプチド、および、これを含むインフルエンザウイルス感染症の予防・治療薬2016

    • Inventor(s)
      西川喜代孝、高橋美帆、近江純平、他4名
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-25
    • Data Source
      KAKENHI-PROJECT-15K08480
  • [Patent] CT阻害4価ペプチドおよびコレラ治療薬2013

    • Inventor(s)
      西川喜代孝、高橋美帆、山本洋
    • Industrial Property Rights Holder
      学校法人同志社、(独)国立国際医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-051032
    • Filing Date
      2013-03-13
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Patent] Stx2阻害4価ペプチドおよびこのStx2阻害4価ペプチドを含む治療薬2013

    • Inventor(s)
      西川喜代孝、高橋美帆、三井貴瑛
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      2013-013746
    • Filing Date
      2013-01-28
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Patent] CT阻害4価ペプチドおよびコレラ治療薬2013

    • Inventor(s)
      西川喜代孝、高橋美帆、山本洋
    • Industrial Property Rights Holder
      学校法人同志社、(独)国立国際医療研究センター
    • Industrial Property Number
      2013-051032
    • Filing Date
      2013-03-13
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Patent] CaMKII阻害ペプチドおよびこれを含有するCaMKII阻害剤2011

    • Inventor(s)
      西川喜代孝、高橋美帆、西村浩輝
    • Industrial Property Rights Holder
      学校法人同志社、国立大学法人東京医科歯科大学
    • Industrial Property Number
      2011-017295
    • Filing Date
      2011-01-28
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Patent] Stx毒性阻害ペプチドおよびStxに起因する疾患の治療薬2010

    • Inventor(s)
      西川喜代孝、高橋美帆、津々木一恵
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      2010-019728
    • Filing Date
      2010-01-29
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Patent] ペプチドのスクリーニング法2010

    • Inventor(s)
      西川喜代孝, 高橋美帆, 加藤美帆子
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      2010-019731
    • Filing Date
      2010-01-29
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Patent] Stx毒性阻害ペプチドおよびStxに起因する疾患の治療薬2010

    • Inventor(s)
      西川喜代孝, 高橋美帆, 津々木一恵
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      2010-019728
    • Filing Date
      2010-01-29
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Patent] ペプチドのスクリーニング法2010

    • Inventor(s)
      西川喜代孝、高橋美帆、加藤美帆子
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      2010-019731
    • Filing Date
      2010-01-29
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Presentation] Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.2018

    • Author(s)
      Miho Watanabe-Takahashi, Jun Motoyama, Jyoji Yamate, Shinji Yamasaki and Kiyotaka Nishikawa
    • Organizer
      VTEC2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07128
  • [Presentation] 受容体結合部位を標的とした新規コレラ毒素阻害薬の開発2013

    • Author(s)
      山本洋、西川喜代孝、高橋美帆
    • Organizer
      濱端崇第86回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] Peptide-based STx- neutralizers for treatment of STEC infections2012

    • Author(s)
      Watanabe-Takahashi M., Tsutsuki K., Kita E., Kiyotaka nishikawa
    • Organizer
      VTEC2012
    • Place of Presentation
      The Netherland
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] 新規ペプチド性Stx阻害薬MMA-tetとStxとの結合様式の解析2012

    • Author(s)
      高橋美帆
    • Organizer
      第16回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      秋田
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] Stx阻害薬MMA-tetの作用メカニズムの解明2012

    • Author(s)
      竹中康章、高橋美帆、西川喜代孝
    • Organizer
      第16回腸管出血性大腸菌感染症研究会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] 新規ペプチド性Stx阻害薬MMA-tetとStxとの結合様式の解析2012

    • Author(s)
      高橋美帆、津々木一恵、飯田将太、西川喜代孝
    • Organizer
      第16回腸管出血性大腸菌感染症研究会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] 受容体結合部位を標的とした新規コレラ毒素阻害薬の開発2012

    • Author(s)
      山本洋、高橋美帆、濱端崇、西川喜代孝
    • Organizer
      第85回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] Ca2+/カルモジュリン依存性プロテインキナーゼII阻害ペプチドの開発2012

    • Author(s)
      西園貴志、西村浩輝、小林俊彦、高橋美帆、反町典子、高柳広、尾藤晴彦、西川喜代孝
    • Organizer
      第85回日本生化学会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] バリアント特異的Stx阻害ペプチドの新規スクリーニング法の確立2012

    • Author(s)
      三井貴瑛、高橋美帆、山崎伸二、西川喜代孝
    • Organizer
      第85回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] バリアント特異的Stx阻害薬開発のための新規スクリーニング法の確立2011

    • Author(s)
      三井 貴瑛、章白浩、高橋美帆、山崎伸二、西川喜代孝
    • Organizer
      第15回腸管出血性大腸菌感染症研究会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] 新規ペプチド性Shiga toxin阻害薬とStxとの結合分子機構の解析2011

    • Author(s)
      高橋美帆
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      ツインメッセ静岡(紙上開催)
    • Year and Date
      2011-03-30
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] 新規ペプチド性Shiga toxin阻害薬とStxとの結合分子機構の解析2011

    • Author(s)
      高橋美帆、津々木一恵、西川喜代孝
    • Organizer
      日本薬学会 第131年会
    • Data Source
      KAKENHI-PROJECT-22790418
  • [Presentation] 新規ペプチド性 Shiga toxin 阻害薬の生体内作用機構の解明2010

    • Author(s)
      高橋美帆、佐藤寿男、土肥多恵子、野口範子、加納ふみ、村田昌之、濱端崇、名取泰博、西川喜代孝
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Presentation] 新規ペプチド性Shiga toxin阻害薬の生体内作用機構の解明2010

    • Author(s)
      高橋美帆、佐藤寿男、土肥多恵子、野口範子、加納ふみ、村田昌之、濱端崇、名取泰博、西川喜代孝
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Presentation] 新規ペプチド性Stx阻害薬の生体内作用機構の解明2009

    • Author(s)
      高橋美帆、佐藤寿男、土肥多恵子、野口範子、加納ふみ、村田昌之、濱端崇、名取泰博、西川喜代孝
    • Organizer
      第13回腸管出血性大腸菌感染症シンポジウム
    • Place of Presentation
      大阪府立大学りんくうキャンパス獣医学舎多目的ホール(大阪)
    • Year and Date
      2009-10-16
    • Data Source
      KAKENHI-PROJECT-20790118
  • [Presentation] クラスター効果に基づく強い相互作用を阻害する技術、多価型ペプチドライブラリー法2009

    • Author(s)
      高橋美帆
    • Organizer
      細菌学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-03-13
    • Data Source
      KAKENHI-PROJECT-20790118
  • 1.  Kawashima Rei (70392389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  鎌田 弥生 (00410035)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  藤田 朋恵 (20296510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  市川 尊文 (30245378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  西川 喜代孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  加納 ふみ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  舟本 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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