Nishimasu Hiroshi 西増弘志

… Alternative Names

NISHIMASU Hiroshi 西増弘志

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Researcher Number	00467044
Other IDs
Affiliation (Current)	2025: 東京大学, 先端科学技術研究センター, 教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 東京大学, 先端科学技術研究センター, 教授 2018 – 2019: 東京大学, 大学院理学系研究科(理学部), 准教授 2016 – 2017: 東京大学, 大学院理学系研究科(理学部), 助教 2011 – 2016: The University of Tokyo, 理学(系)研究科(研究院), 助教 2010 – 2011: The University of Tokyo, 大学院・理学系研究科, 特任助教 2008 – 2009: The University of Tokyo, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Structural biochemistry / Broad Section G / Basic Section 43020:Structural biochemistry-related / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Transformative Research Areas, Section (III) / Medium-sized Section 28:Nano/micro science and related fields / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 結晶構造 / CRISPR / RNA / 核酸 / タンパク質 / クライオ電子顕微鏡 / CRISPR-Cas9 / piRNA / innate immunity / helicase … More / 免疫 / RNAヘリカーゼ / Cas12k / 結晶構造解析 / 立体構造 / RNAサイレンシング / 蛋白質 / 高速AFM / CRISPR-Cas / Ribonuclease / Crystal structure / Maelstrom / ゲノム編集 / Argonaute / Cas9 / 非コードRNA / ENPP / X線結晶構造解析 / リゾホスファチジルコリン / 細胞外酵素 / X線結晶構造 / 骨形成 / Enpp … More Except Principal Investigator X線結晶構造解析 / 単粒子解析 / トモグラフィー / クライオ電子顕微鏡 / 立体構造 / デジタルバイオロジー / 1分子計測 / 1分子生物物理学 / 非増幅核酸検査 / デジタルバイオ計測 / 非増幅核酸検出 / 非増幅遺伝子検査 / デジタルリキッドバイオプシー / bioMEMS / CRISPR-Cas / 変異アリル特異的 / Cas9 / 変異アレル特異的編集 / 遺伝子治療 / 機能獲得型変異 / 原発性免疫不全症 / ゲノム編集 Less

「動く遺伝子」トランスポゾンの転移機構解明と応用技術開発Principal Investigator
- Principal Investigator
  
  西増弘志
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  The University of Tokyo
Development of new CRISPR-based genome engineering technologiesPrincipal Investigator
- Principal Investigator
  
  西増弘志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Structural and functional analysis of diverse RNA helicases involved in innate immunityPrincipal Investigator
- Principal Investigator
  
  西増弘志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Development of a novel diagnostic method for viral infections based on digital bioanalysis
- Principal Investigator
  
  Watanabe Rikiya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Institute of Physical and Chemical Research
Structural Analysis of Non Domain Biopolymer
- Principal Investigator
  
  伊藤拓宏
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
Development of new CRISPR-based genome engineering technologiesPrincipal Investigator
- Principal Investigator
  
  Nishimasu Hiroshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Genome editing-based gene therapy for primary immunodeficiency caused by dominant gain-of-function mutations.
- Principal Investigator
  
  Uchiyama Toru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
Improvement of genome-editing technologies by engineering of CRISPR-Cas9Principal Investigator
- Principal Investigator
  
  Nishimasu Hiroshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural and functional analysis of RNA-guided effector nucleasesPrincipal Investigator
- Principal Investigator
  
  Nishimasu Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Action mechanism of CRISPR-Cas9Principal Investigator
- Principal Investigator
  
  西増弘志
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
立体構造から理解するRNAタクソノミPrincipal Investigator
- Principal Investigator
  
  西増弘志
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of RNA silencingPrincipal Investigator
- Principal Investigator
  
  Nishimasu Hiroshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Crystal structure of the extracellular glycoprotein Enpp1Principal Investigator
- Principal Investigator
  
  NISHIMASU Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
真核細胞におけるRNAサイレンシングの構造基盤の解明Principal Investigator
- Principal Investigator
  
  西増弘志
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structure and function of small RNA-protein complexesPrincipal Investigator
- Principal Investigator
  
  NISHIMASU Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo

[Book] 脂質メディエーター産生酵素オートタキシンの構造機能解析、濡木理実験医学2012
- Author(s)
  石谷隆一郎、西増弘志、高木淳一、青木淳賢
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23687014
[Book] 実験医学増刊シグナル伝達研究最前線2012 翻訳後修飾,解析技術,疾患との連関から創薬応用まで2012
- Author(s)
  石谷隆一郎, 西増弘志, 高木淳一, 青木淳賢, 濡木理
- Total Pages
  224
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23687014
[Book] 実験医学増刊拡大・進展を続けるRNA研究の最先端2010
- Author(s)
  西増弘志
- Total Pages
  207
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-22115504
[Book] 実験医学増刊拡大・進展を続けるRNA研究の最先端2010
- Author(s)
  西増弘志
- Total Pages
  207
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20770079
[Book] 実験医学増刊拡大・進展を続けるRNA研究の最先端2010
- Author(s)
  西増弘志, 濡木理
- Total Pages
  207
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Compact wide-field femtoliter-chamber imaging system for high-speed and accurate digital bioanalysis2023
- Author(s)
  Iida, T., Ando, J., Shinoda, H., Makino, A., Yoshimura, M., Murai, K., Mori, M., Takaeuchi, H., Noda, T., Nishimasu, H., & *Watanabe, R.
- Journal Title
  
  Lab on a Chip
  
  Volume: 23 Issue: 4 Pages: 684-691
- DOI
  10.1039/d2lc00741j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04645
[Journal Article] Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis2022
- Author(s)
  Shinoda Hajime、Iida Tatsuya、Makino Asami、Yoshimura Mami、Ishikawa Junichiro、Ando Jun、Murai Kazue、Sugiyama Katsumi、Muramoto Yukiko、Nakano Masahiro、Kiga Kotaro、Cui Longzhu、Nureki Osamu、Takeuchi Hiroaki、Noda Takeshi、Nishimasu Hiroshi、Watanabe Rikiya
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 473-473
- DOI
  10.1038/s42003-022-03433-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07086, KAKENHI-PROJECT-22K07099, KAKENHI-PROJECT-21H04645, KAKENHI-PROJECT-21K19488, KAKENHI-PLANNED-20H05931, KAKENHI-PROJECT-23K21171
[Journal Article] RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease2022
- Author(s)
  Kato Kazuki、Okazaki Sae、Schmitt-Ulms Cian、Jiang Kaiyi、Zhou Wenyuan、Ishikawa Junichiro、Isayama Yukari、Adachi Shungo、Nishizawa Tomohiro、Makarova Kira S.、Koonin Eugene V.、Abudayyeh Omar O.、Gootenberg Jonathan S.、Nishimasu Hiroshi
- Journal Title
  
  Science
  
  Volume: 378 Issue: 6622 Pages: 882-889
- DOI
  10.1126/science.add7347
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05281
[Journal Article] Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex2022
- Author(s)
  Kato Kazuki、Zhou Wenyuan、Okazaki Sae、Isayama Yukari、Nishizawa Tomohiro、Gootenberg Jonathan S.、Abudayyeh Omar O.、Nishimasu Hiroshi
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 13 Pages: 2324-2337.e16
- DOI
  10.1016/j.cell.2022.05.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05281
[Journal Article] Engineered Campylobacter jejuni Cas9 variant with enhanced activity and broader targeting range2022
- Author(s)
  Nakagawa Ryoya、Ishiguro Soh、Okazaki Sae、Mori Hideto、Tanaka Mamoru、Aburatani Hiroyuki、Yachie Nozomu、Nishimasu Hiroshi、Nureki Osamu
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1-8
- DOI
  10.1038/s42003-022-03149-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19284, KAKENHI-PROJECT-22KJ0608
[Journal Article] RNA-activated protein cleavage with a CRISPR-associated endopeptidase2022
- Author(s)
  Strecker Jonathan、Demircioglu F. Esra、Li David、Faure Guilhem、Wilkinson Max E.、Gootenberg Jonathan S.、Abudayyeh Omar O.、Nishimasu Hiroshi、Macrae Rhiannon K.、Zhang Feng
- Journal Title
  
  Science
  
  Volume: 378 Issue: 6622 Pages: 874-881
- DOI
  10.1126/science.add7450
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05281
[Journal Article] Structure of the miniature type V-F CRISPR-Cas effector enzyme2021
- Author(s)
  Takeda Satoru N.、Nakagawa Ryoya、Okazaki Sae、Hirano Hisato、Kobayashi Kan、Kusakizako Tsukasa、Nishizawa Tomohiro、Yamashita Keitaro、Nishimasu Hiroshi、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 3 Pages: 558-570.e3
- DOI
  10.1016/j.molcel.2020.11.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20579, KAKENHI-PROJECT-18K19284, KAKENHI-PROJECT-20K15754
[Journal Article] Amplification-free RNA detection with CRISPR?Cas132021
- Author(s)
  Shinoda Hajime、Taguchi Yuya、Nakagawa Ryoya、Makino Asami、Okazaki Sae、Nakano Masahiro、Muramoto Yukiko、Takahashi Chiharu、Takahashi Ikuko、Ando Jun、Noda Takeshi、Nureki Osamu、Nishimasu Hiroshi、Watanabe Rikiya
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 476-476
- DOI
  10.1038/s42003-021-02001-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06401, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-19K07575, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-20H05931, KAKENHI-PROJECT-21H04645, KAKENHI-PROJECT-22KJ0608
[Journal Article] Publisher Correction: Base editors for simultaneous introduction of C-to-T and A-to-G mutations2020
- Author(s)
  Sakata Rina C.、Ishiguro Soh、Mori Hideto、Tanaka Mamoru、Tatsuno Kenji、Ueda Hiroki、Yamamoto Shogo、Seki Motoaki、Masuyama Nanami、Nishida Keiji、Nishimasu Hiroshi、Arakawa Kazuharu、Kondo Akihiko、Nureki Osamu、Tomita Masaru、Aburatani Hiroyuki、Yachie Nozomu
- Journal Title
  
  Nature Biotechnology
  
  Volume: 38 Issue: 7 Pages: 901-901
- DOI
  10.1038/s41587-020-0585-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20579, KAKENHI-PROJECT-18K19284
[Journal Article] Crystal structure of Drosophila Piwi.2020
- Author(s)
  Yamaguchi, S., Oe, A., Nishida, KM., Yamashita, K., Kajiya, A., Hirano, S., Matsumoto, N., Dohmae, N., Ishitani, R., Saito, K., Siomi, H., Nishimasu, H., Siomi, MC., and Nureki, O.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 858-858
- DOI
  10.1038/s41467-020-14687-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05753, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-18H02379, KAKENHI-PROJECT-18H02384, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H05466, KAKENHI-PLANNED-16H06574
[Journal Article] Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas92019
- Author(s)
  Hirano Seiichi、Abudayyeh Omar O.、Gootenberg Jonathan S.、Horii Takuro、Ishitani Ryuichiro、Hatada Izuho、Zhang Feng、Nishimasu Hiroshi、Nureki Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1968-1968
- DOI
  10.1038/s41467-019-09741-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19284, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-18H02384, KAKENHI-PROJECT-17J05841
[Journal Article] Cap-specific terminal N6-methylation of RNA by an RNA polymerase II?associated methyltransferase2018
- Author(s)
  Akichika Shinichiro、Hirano Seiichi、Shichino Yuichi、Suzuki Takeo、Nishimasu Hiroshi、Ishitani Ryuichiro、Sugita Ai、Hirose Yutaka、Iwasaki Shintaro、Nureki Osamu、Suzuki Tsutomu
- Journal Title
  
  Science
  
  Volume: 363 Issue: 363 Pages: 1-7
- DOI
  10.1126/science.aav0080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07282, KAKENHI-PROJECT-18K19141, KAKENHI-PUBLICLY-17H05592, KAKENHI-ORGANIZER-26113001, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19J11333, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-18H02384, KAKENHI-PUBLICLY-17H05679, KAKENHI-PROJECT-17H04998
[Journal Article] Engineered CRISPR-Cas9 nuclease with expanded targeting space2018
- Author(s)
  Nishimasu Hiroshi、Shi Xi、Ishiguro Soh、Gao Linyi、Hirano Seiichi、Okazaki Sae、Noda Taichi、Abudayyeh Omar O.、Gootenberg Jonathan S.、Mori Hideto、Oura Seiya、Holmes Benjamin、Tanaka Mamoru、Seki Motoaki、Hirano Hisato、Aburatani Hiroyuki、Ishitani Ryuichiro、Ikawa Masahito、Yachie Nozomu、Zhang Feng、Nureki Osamu
- Journal Title
  
  Science
  
  Volume: 361 Issue: 6408 Pages: 1259-1262
- DOI
  10.1126/science.aas9129
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19471, KAKENHI-PROJECT-18K19777, KAKENHI-PLANNED-16H06574, KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-18H02428, KAKENHI-PROJECT-16J06287, KAKENHI-PROJECT-18H02384
[Journal Article] Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM2018
- Author(s)
  Endo Masaki、Mikami Masafumi、Endo Akira、Kaya Hidetaka、Itoh Takeshi、Nishimasu Hiroshi、Nureki Osamu、Toki Seiichi
- Journal Title
  
  Nature Plants
  
  Volume: 5 Issue: 1 Pages: 14-17
- DOI
  10.1038/s41477-018-0321-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-16J06425, KAKENHI-PROJECT-18H02384
[Journal Article] Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 12018
- Author(s)
  Kato Kazuki、Nishimasu Hiroshi、Oikawa Daisuke、Hirano Seiichi、Hirano Hisato、Kasuya Go、Ishitani Ryuichiro、Tokunaga Fuminori、Nureki Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 4424-4424
- DOI
  10.1038/s41467-018-06922-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06574, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H02384, KAKENHI-PROJECT-18K06967
[Journal Article] Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy2017
- Author(s)
  Shibata Mikihiro、Nishimasu Hiroshi、Kodera Noriyuki、Hirano Seiichi、Ando Toshio、Uchihashi Takayuki、Nureki Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1430-1430
- DOI
  10.1038/s41467-017-01466-8
- NAID
  120006374160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19345, KAKENHI-PUBLICLY-16H00758, KAKENHI-PUBLICLY-16H00830, KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H06121, KAKENHI-PROJECT-15H03540, KAKENHI-PROJECT-15H04360, KAKENHI-PROJECT-16K18523
[Journal Article] Engineered Cpf1 variants with altered PAM specificities2017
- Author(s)
  Gao Linyi、Cox David B T、Yan Winston X、Manteiga John C、Schneider Martin W、Yamano Takashi、Nishimasu Hiroshi、Nureki Osamu、Crosetto Nicola、Zhang Feng
- Journal Title
  
  Nature Biotechnology
  
  Volume: 35 Issue: 8 Pages: 789-792
- DOI
  10.1038/nbt.3900
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Journal Article] Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf12017
- Author(s)
  Yamano Takashi、Zetsche Bernd、Ishitani Ryuichiro、Zhang Feng、Nishimasu Hiroshi、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 67 Issue: 4 Pages: 633-645
- DOI
  10.1016/j.molcel.2017.06.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H03640
[Journal Article] Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf12017
- Author(s)
  Nishimasu Hiroshi、Yamano Takashi、Gao Linyi、Zhang Feng、Ishitani Ryuichiro、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 67 Issue: 1 Pages: 139-147
- DOI
  10.1016/j.molcel.2017.04.019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H03640
[Journal Article] Crystal structure of silkworm PIWI-clade Argonaute Siwi bound to piRNA2016
- Author(s)
  Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O
- Journal Title
  
  Cell
  
  Volume: 167 Issue: 2 Pages: 484-497
- DOI
  10.1016/j.cell.2016.09.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26291010, KAKENHI-PROJECT-15K06948, KAKENHI-PROJECT-16K18556
[Journal Article] Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems2016
- Author(s)
  Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, Nishimasu H, Nureki O
- Journal Title
  
  Mol Cell
  
  Volume: 65 Issue: 6 Pages: 1109-1121
- DOI
  10.1016/j.molcel.2017.02.007
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463, KAKENHI-PROJECT-26291010, KAKENHI-PROJECT-17H03640
[Journal Article] Structure and Engineering of Francisella novicida Cas92016
- Author(s)
  Hisato Hirano, Jonathan S. Gootenberg, Takuro Horii, Omar O. Abudayyeh, Mika Kimura, Takanori Nakane, Ryuichiro Ishitani, Izuho Hatada, Feng Zhang, Hiroshi Nishimasu, Osamu Nureki
- Journal Title
  
  Cell
  
  Volume: 164 Issue: 5 Pages: 950-961
- DOI
  10.1016/j.cell.2016.01.039
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26291010
[Journal Article] Structure of Cpf1 in Complex with Guide RNA and Target DNA2016
- Author(s)
  Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O
- Journal Title
  
  Cell
  
  Volume: 165 Issue: 4 Pages: 946-962
- DOI
  10.1016/j.cell.2016.04.003
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463, KAKENHI-PROJECT-16J08032, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26291010
[Journal Article] Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas92016
- Author(s)
  Seiichi Hirano, Hiroshi Nishimasu, Ryuichiro Ishitani, Osamu Nureki
- Journal Title
  
  Molecular Cell
  
  Volume: 61 Issue: 6 Pages: 886-894
- DOI
  10.1016/j.molcel.2016.02.018
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463, KAKENHI-PROJECT-26291010, KAKENHI-PROJECT-25291011
[Journal Article] Crystal Structure of Staphylococcus aureus Cas92015
- Author(s)
  Hiroshi Nishimasu, Le Cong, Winston X. Yan, F. Ann Ran, Bernd Zetsche, Yinqing Li, Arisa Kurabayashi, Ryuichiro Ishitani, Feng Zhang, Osamu Nureki
- Journal Title
  
  Cell
  
  Volume: 162 Issue: 5 Pages: 1113-1126
- DOI
  10.1016/j.cell.2015.08.007
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26291010
[Journal Article] Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex2015
- Author(s)
  Konermann S*, Brigham MD*, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F
- Journal Title
  
  Nature
  
  Volume: 517 Issue: 7536 Pages: 583-588
- DOI
  10.1038/nature14136
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291010
[Journal Article] Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom2015
- Author(s)
  Naoki Matsumoto, Kaoru Sato, Hiroshi Nishimasu, Yurika Namba, Kana Miyakubi, Naoshi Dohmae, Ryuichiro Ishitani, Haruhiko Siomi, Mikiko C. Siomi, Osamu Nureki
- Journal Title
  
  Cell Reports
  
  Volume: 11 Issue: 3 Pages: 1-10
- DOI
  10.1016/j.celrep.2015.03.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-26291010, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-13J08341, KAKENHI-PROJECT-26870112, KAKENHI-PROJECT-25291011
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp62014
- Author(s)
  J. Morita, K. Kato, E. Mihara, R. Ishitani, J. Takagi, H. Nishimasu, J. Aoki, O. Nureki
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687014
[Journal Article] Crystal structure of Cas9 in complex with guide RNA and target DNA2014
- Author(s)
  Nishimasu H, Ran FA, Hsu PD, Konermann S, Shehata SI, Dohmae N, Ishitani R, Zhang F, Nureki O
- Journal Title
  
  Cell
  
  Volume: 156(5) Issue: 5 Pages: 935-949
- DOI
  10.1016/j.cell.2014.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687014, KAKENHI-PUBLICLY-25116705
[Journal Article] Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe2013
- Author(s)
  Mitsuyasu Kawaguchi
- Journal Title
  
  ACS chemical biology
  
  Volume: 8 Issue: 8 Pages: 1713-1721
- DOI
  10.1021/cb400150c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10869, KAKENHI-PROJECT-22000006, KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-23687014, KAKENHI-PUBLICLY-25116705, KAKENHI-PROJECT-25291011
[Journal Article] Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change2013
- Author(s)
  Yamagata, K., Goto, Y., Nishimasu, H., Morimoto, J., Ishitani, R., Dohmae, N., Takeda, N., Nagai, R., Komuro, I., Suga, H., Nureki, O
- Journal Title
  
  Structure
  
  Volume: 22 Issue: 2 Pages: 345-352
- DOI
  10.1016/j.str.2013.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-23687014, KAKENHI-PUBLICLY-25116705, KAKENHI-PROJECT-25291011
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp12012
- Author(s)
  Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
- Journal Title
  
  Acta Crystallogr
  
  Volume: F68 Issue: 7 Pages: 778-782
- DOI
  10.1107/s1744309112019306
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-24651260, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O
- Journal Title
  
  EMBO J.
  
  Volume: 31 Issue: 19 Pages: 3856-3870
- DOI
  10.1038/emboj.2012.241
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22249008, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23390070, KAKENHI-PROJECT-23591263, KAKENHI-PROJECT-23657075, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-23700517, KAKENHI-PROJECT-24659136, KAKENHI-PLANNED-22117006, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002
[Journal Article] A 3D view of autotaxin2012
- Author(s)
  Nishimasu H, Ishitani R, Aoki J, Nureki O
- Journal Title
  
  Trends Pharmacol Sci
  
  Volume: 33 Issue: 3 Pages: 138-145
- DOI
  10.1016/j.tips.2011.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390015, KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22659013, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Zucchini from Drosophila melanogaster2012
- Author(s)
  Fukuhara S, Nishimasu H, Bonnefond L, Matsumoto N, Ishitani R, Nureki O
- Journal Title
  
  Acta Crystallogr
  
  Volume: F68 Issue: 11 Pages: 1346-1350
- DOI
  10.1107/s1744309112038936
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014
[Journal Article] The tRNA recognition mechanism of folate/FAD-dependent tRNA methyltransferase (TrmFO)2012
- Author(s)
  Yamagami R, Yamashita K, Nishimasu H, Tomikawa C, Ochi A, Iwashita C, Hirata A, Ishitani R, Nureki O, Hori H
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 51 Pages: 42480-42480
- DOI
  10.1074/jbc.m112.390112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23350081, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-24655156
[Journal Article] Molecular Dynamics Simulation of Autotaxin : Roles of the Nuclease-like Domain and the Glycan Modification.2012
- Author(s)
  Michio Koyama, Hiroshi Nishimasu, Ryuichiro Ishitani, Osamu Nureki
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 116 Issue: 39 Pages: 11798-11808
- DOI
  10.1021/jp303198u
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09861, KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014
[Journal Article] Structure and function of Zucchini endoribonuclease in piRNA biogenesis.2012
- Author(s)
  Hiroshi Nishimasu, Hirotsugu Ishizu
- Journal Title
  
  Nature
  
  Volume: 491 Issue: 7423 Pages: 284-287
- DOI
  10.1038/nature11509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J56562, KAKENHI-PROJECT-11J05211, KAKENHI-PROJECT-20221008, KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-24227004
[Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling2012
- Author(s)
  Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
- Journal Title
  
  Proc. Natl Acad. Sci. U. S. A.
  
  Volume: 109 Issue: 42 Pages: 16876-16881
- DOI
  10.1073/pnas.1208017109
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-24651260, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] 脂質メディエーター産生酵素ATXの結晶構造2011
- Author(s)
  西増弘志, 高木淳一, 青木淳賢, 濡木理
- Journal Title
  
  日本結晶学会誌
  
  Volume: 53 Pages: 207-212
- NAID
  10029371554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687014
[Journal Article] Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase2011
- Author(s)
  Fushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T
- Journal Title
  
  Nature
  
  Volume: 478(7370) Issue: 7370 Pages: 538-541
- DOI
  10.1038/nature10457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687014
[Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators2011
- Author(s)
  H.Nishimasu, S.Okudaira, K.Hama, E.Mihara, N.Dohmae, A.Inoue, R.Ishitani, J.Takagi, J.Aoki, O.Nureki.
- Journal Title
  
  Nat Struct Mol Biol 18
  
  Pages: 205-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Crystal structure of a PFU-PUL domain pair of Saccharomyces cerevisiae Doa1/Ufd3R.2010
- Author(s)
  Nishimasu, H.Komori, Y.Higuchi, H.Nishimasu, H.Hiroaki.
- Journal Title
  
  Kobe J Med Sci 56
  
  Pages: 125-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase2009
- Author(s)
  H.Nishimasu, R.Ishitani, K.Yamashita, C.Iwashita, A.Hirata, H.Hori, O.Nureki
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 106
  
  Pages: 8180-8185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW22009
- Author(s)
  M.Umitsu, H.Nishimasu, A.Noma, T.Suzuki, R.Ishitani, O.Nureki
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 106
  
  Pages: 15616-15621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Crystallization and preliminary X-ray diffraction analysis of the truncated cytosolic domain of the iron transporter FeoB2009
- Author(s)
  Y.Jin, M.Hattori, H.Nishimasu, R.Ishitani, O.Nureki.
- Journal Title
  
  Acta Crystallogr F 65
  
  Pages: 784-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Structural basis of novel interactions between the small-GTPase and GDI-like domains in prokaryotic FeoB iron transporter2009
- Author(s)
  M.Hattori, Y.Jin, H.Nishimasu, Y.Tanaka, M.Mochizuki, T.Uchiumi, R.Ishitani, K.Ito, O.Nureki.
- Journal Title
  
  Structure 17
  
  Pages: 1345-1355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW22009
- Author(s)
  M.Umitsu, H.Nishimasu, A.Noma, T.Suzuki, R.Ishitani, O.Nureki.
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 15616-15621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Journal Article] Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase2009
- Author(s)
  H.Nishimasu, R.Ishitani, K.Yamashita, C.Iwashita, A.Hirata, H.Hori, O.Nureki.
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 8180-8185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770079
[Patent] Crispr-Cas, Crystal Structure and Uses Thereof2014
- Inventor(s)
  Feng Zhang, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani
- Industrial Property Rights Holder
  Feng Zhang, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-22
- Overseas
- Data Source
  KAKENHI-PROJECT-23687014
[Patent] オートタキシン阻害活性を有する縮合ピラゾール誘導体2014
- Inventor(s)
  長野哲雄、岡部隆義、小島宏建、川口充康、濡木理、石谷隆一郎、西増弘志、青木淳賢、藤越千明、加藤学、大段正英、田中伸幸
- Industrial Property Rights Holder
  長野哲雄、岡部隆義、小島宏建、川口充康、濡木理、石谷隆一郎、西増弘志、青木淳賢、藤越千明、加藤学、大段正英、田中伸幸
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-037591
- Filing Date
  2014-02-27
- Data Source
  KAKENHI-PROJECT-23687014
[Patent] オートタキシン阻害活性を有する8-置換イミダゾピリミジノン誘導体2014
- Inventor(s)
  長野哲雄、岡部隆義、小島宏建、川口充康、濡木理、石谷隆一郎、西増弘志、青木淳賢、藤越千明、田中伸幸、舘野佑介、和田俊博
- Industrial Property Rights Holder
  長野哲雄、岡部隆義、小島宏建、川口充康、濡木理、石谷隆一郎、西増弘志、青木淳賢、藤越千明、田中伸幸、舘野佑介、和田俊博
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-27
- Overseas
- Data Source
  KAKENHI-PROJECT-23687014
[Patent] Crispr-Cas, Crystal Structure and Uses Thereof2013
- Inventor(s)
  Feng Zhang, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani
- Industrial Property Rights Holder
  Feng Zhang, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-12
- Overseas
- Data Source
  KAKENHI-PROJECT-23687014
[Patent] Crispr-Cas, New Nickases and Uses Thereof2013
- Inventor(s)
  Feng Zhang, Osamu Nureki, Hiroshi Nishimasu
- Industrial Property Rights Holder
  Feng Zhang, Osamu Nureki, Hiroshi Nishimasu
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-12
- Overseas
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] Structural mechanism of IS110 bridge recombinases2024
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Keystone Symposia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00403
[Presentation] Structural mechanism of IS110 bridge recombinases2024
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Keystone Symposia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05281
[Presentation] Structure, function and engineering of the type III-E CRISPR nuclease-protease complex2023
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Cold Spring Harbor Asia Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00403
[Presentation] Structure and engineering of CRISPR nuclease-protease2023
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Frontiers in Genome Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00403
[Presentation] Structure, function and engineering of the type III-E CRISPR nuclease-protease complex2023
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Cold Spring Harbor Asia Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05281
[Presentation] Structure and engineering of CRISPR nuclease-protease2023
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Frontiers in Genome Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05281
[Presentation] Structure, Mechanism & Evolution of CRISPR-Cas Enzymes2020
- Author(s)
  Hiroshi Nishimasu
- Organizer
  MBSJ2020
- Invited
- Data Source
  KAKENHI-PROJECT-18K19284
[Presentation] Structure, Mechanism & Evolution of CRISPR-Cas Enzymes2020
- Author(s)
  Hiroshi Nishimasu
- Organizer
  The 58th Annual Meeting of the Biophysical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-18K19284
[Presentation] 立体構造に基づく CRISPR-Cas9の分子改変2018
- Author(s)
  西増弘志
- Organizer
  MBSJ2018
- Invited
- Data Source
  KAKENHI-PROJECT-18H02384
[Presentation] 立体構造に基づくCRISPR-Cas9の分子改変2018
- Author(s)
  西増弘志
- Organizer
  MBSJ2018
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] Engineered CRISPR-Cas9 recognizing a single guanine PAM2018
- Author(s)
  Hiroshi Nishimasu
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02384
[Presentation] Engineered CRISPR-Cas9 recognizing a single guanine PAM2018
- Author(s)
  Hiroshi Nishimasu
- Organizer
  日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] CRISPR-Cas9の結晶構造と機能改変2017
- Author(s)
  西増弘志
- Organizer
  千里ライフサイエンスセミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] CRISPR-Cas9の結晶構造と機能改変2017
- Author(s)
  西増弘志、濡木　理
- Organizer
  日本結晶学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] CRISPR-Cas9の結晶構造と機能改変2017
- Author(s)
  西増弘志
- Organizer
  蛋白研セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] Structure, Dynamics & Engineering of CRISPR-Cas92017
- Author(s)
  Nishimasu Hiroshi、Nureki Osamu
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy2017
- Author(s)
  Nishimasu Hiroshi、Shibata Mikihiro、Kodera Noriyuki、Hirano Seiichi、Ando Toshio、Uchihashi Takayuki、Nureki Osamu
- Organizer
  CRISPR2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05592
[Presentation] CRISPR-Cas9の機能と構造2016
- Author(s)
  西増弘志
- Organizer
  第17回極限環境生物学会
- Place of Presentation
  東京工業大学すずかけ台キャンパス（神奈川県横浜市）
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01463
[Presentation] Crystal structure of silkworm PIWI, Siwi, in complex with piRNA2016
- Author(s)
  Hiroshi Nishimasu, Naoki Matsumoto, Kazuhiro Sakakibara, Kazumichi Nishida, Ryuichiro Ishitani, Haruhiko Siomi, Mikiko C. Siomi, Osamu Nureki
- Organizer
  RNA2016
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2016-06-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01463
[Presentation] Crystal structure of silkworm PIWI, Siwi, in complex with piRNA2016
- Author(s)
  Hiroshi Nishimasu, Naoki Matsumoto, Kazuhiro Sakakibara, Kazumichi Nishida, Ryuichiro Ishitani, Haruhiko Siomi, Mikiko C. Siomi, Osamu Nureki
- Organizer
  RNA2016
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2016-06-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] CRISPR-Cas9およびCRIPSR-Cpf1の結晶構造2016
- Author(s)
  西増弘志、山野峻、平野央人、石谷隆一郎、濡木理
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01463
[Presentation] CRISPR-Cas9の結晶構造2015
- Author(s)
  西増弘志
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学（石川県金沢市）
- Year and Date
  2015-09-15
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01463
[Presentation] 小型CRISPR-Cas9の結晶構造2015
- Author(s)
  西増弘志、石谷隆一郎、濡木理
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PUBLICLY-15H01463
[Presentation] 小型CRISPR-Cas9の結晶構造2015
- Author(s)
  西増弘志、石谷隆一郎、濡木理
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] CRISPR-Cas9の結晶構造2015
- Author(s)
  西増弘志
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学（石川県金沢市）
- Year and Date
  2015-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Cas9-ガイド鎖RNA-標的DNAの結晶構造2014
- Author(s)
  西増弘志
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2014-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] 立体構造から迫る酵素の作動機構2014
- Author(s)
  西増弘志
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Cas9-ガイド鎖RNA-標的DNA三者複合体の結晶構造2014
- Author(s)
  西増弘志
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Crystal structure of Cas9 in complex with guide RNA and target DNA2014
- Author(s)
  西増弘志
- Organizer
  The 14th Tokyo RNA Club
- Place of Presentation
  東京大学（東京）
- Year and Date
  2014-05-09
- Invited
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Crystal structure of Cas9 in complex with guide RNA and target DNA2014
- Author(s)
  Hiroshi Nishimasu
- Organizer
  CRISPR2014
- Place of Presentation
  Berlin (Germany)
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Crystal structure of Cas9 in complex with guide RNA and target DNA2014
- Author(s)
  Nishimasu H, Ran FA, Ishitani R, Zhang F, Nureki O
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Crystal structure of Cas9 in complex with guide RNA and target DNA2014
- Author(s)
  Nishimasu H, Ran FA, Ishitani R, Zhang F, Nureki O
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（横浜）
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Cas9を応用した新規技術2014
- Author(s)
  西増弘志
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（横浜）
- Year and Date
  2014-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] Crystal structure of Cas9 in complex with guide RNA and target DNA2014
- Author(s)
  Nishimasu H, Ran FA, Ishitani R, Zhang F, Nureki O
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-26291010
[Presentation] 骨石灰化やインスリンシグナルに関わる細胞外酵素Enpp1の結晶構造2013
- Author(s)
  加藤一希、西増弘志、奥平真一、三原恵美子、石谷隆一郎、高木淳一、青木淳賢
- Organizer
  第13回蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館(鳥取)
- Year and Date
  2013-06-12
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 細胞外酵素Enppファミリーの結晶構造2012
- Author(s)
  西増弘志
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪大学蛋白質研究所(大阪)
- Year and Date
  2012-10-05
- Invited
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling2012
- Author(s)
  Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
- Organizer
  Asian Crystallographic Association meeting 2012
- Place of Presentation
  Adelaid (Australia)
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 細胞外酵素Enppファミリーの結晶構造2012
- Author(s)
  西増弘志
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪大学蛋白質研究所
- Invited
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 古細菌の糖新生酵素フルクトース-1,6-ビスリン酸アルドラーゼ/ホスファターゼは1つの活性部位で2つの化学反応を触媒する2011
- Author(s)
  西増弘志
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県立大学姫路書写キャンパス(招待講演)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 古細菌の糖新生酵素フルクトース-1,6-ビスリン酸アルドラーゼ/ホスファターゼは1つの活性部位で2つの化学反応を触媒する2011
- Author(s)
  西増弘志, 伏信進矢, 服部大紀, 宋賢珍, 若木高善
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 脂質メディエーター産生酵素オートタキシンの結晶構造2011
- Author(s)
  西増弘志, 奥平真一, 濱弘太郎, 三原恵美子, 堂前直, 井上飛鳥, 石谷隆一郎, 高木淳一, 青木淳賢, 濡木理
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  ホテル阪急エキスポパーク(大阪府)
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 脂質メディエーター産生酵素オートタキシンのX線結晶構造2011
- Author(s)
  西増弘志、奥平真一、濱弘太郎、三原恵美子、堂前直、井上飛鳥、石谷隆一郎、高木淳一、青木淳賢、濡木理
- Organizer
  日本結晶学会年会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2011-11-24
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] Crystal structure of autotaxin2011
- Author(s)
  Nishimasu H
- Organizer
  FASEB Research Conference
- Place of Presentation
  Lucca (Italy)
- Year and Date
  2011-08-15
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] 脂質メディエーター産生酵素オートタキシンの結晶構造2011
- Author(s)
  西増弘志, 奥平真一, 濱弘太郎, 三原恵美子, 堂前直, 井上飛鳥, 石谷隆一郎, 高木淳一, 青木淳賢, 濡木理
- Organizer
  平成23年度日本結晶学会年会
- Place of Presentation
  北海道大学学術交流会館
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-23687014
[Presentation] Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase2010
- Author(s)
  Hiroshi Nishimasu
- Organizer
  23rd tRNA workshop
- Place of Presentation
  ポルトガル,アヴェイロ
- Year and Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-20770079
[Presentation] Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW22010
- Author(s)
  西増弘志
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PUBLICLY-22115504
[Presentation] Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase2010
- Author(s)
  西増弘志
- Organizer
  23rd tRNA workshop
- Place of Presentation
  Aveiro, Portugal
- Year and Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-20770079
[Presentation] Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW22010
- Author(s)
  西増弘志
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20770079
[Presentation] 1.0-A resolution structure of a new RNA modification enzyme2009
- Author(s)
  Hiroshi Nishimasu
- Organizer
  Gordon Research Conferences (RNA editing)
- Place of Presentation
  アメリカ,テキサス
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-20770079
[Presentation] 葉酸/FAD依存性tRNA U54メチル化酵素TrmFOの機能と構造2009
- Author(s)
  西増弘志
- Organizer
  第11回RNAミーティング
- Place of Presentation
  新潟朱鷺メッセ
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20770079
[Presentation] 葉酸/FAD依存性tRNA U54メチル化酵素TrmFOの機能と構造2009
- Author(s)
  西増弘志、石谷隆一郎、山下光輝, 岩下知香子, 平田章、堀弘幸、濡木理
- Organizer
  第11回RNAミーティング
- Place of Presentation
  新潟・朱鷺メッセ
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20770079

1. NUREKI Osamu (10272460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. SIOMI Mikiko (20322745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SIOMI Haruhiko (60202107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. SHIBATA Mikihiro (80631027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KODERA Noriyuki (30584635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Uchiyama Toru (10436107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Watanabe Rikiya (30540108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 野田岳志 (00422410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 武内寛明 (20451867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤拓宏 (70401164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Zhang Feng

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. ACHARYA SUNDARAM

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ISHITANI Ryuichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
14. 広瀬豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 青木淳賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 関元昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishimasu Hiroshi 西増 弘志

NISHIMASU Hiroshi 西増 弘志

Research Projects

Research Products

Co-Researchers

「動く遺伝子」トランスポゾンの転移機構解明と応用技術開発Principal Investigator

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Development of new CRISPR-based genome engineering technologiesPrincipal Investigator

Principal Investigator

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Structural and functional analysis of diverse RNA helicases involved in innate immunityPrincipal Investigator

Principal Investigator

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Development of a novel diagnostic method for viral infections based on digital bioanalysis

Principal Investigator

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Structural Analysis of Non Domain Biopolymer

Principal Investigator

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Development of new CRISPR-based genome engineering technologiesPrincipal Investigator

Principal Investigator

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Review Section

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Genome editing-based gene therapy for primary immunodeficiency caused by dominant gain-of-function mutations.

Principal Investigator

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Improvement of genome-editing technologies by engineering of CRISPR-Cas9Principal Investigator

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Structural and functional analysis of RNA-guided effector nucleasesPrincipal Investigator

Principal Investigator

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Action mechanism of CRISPR-Cas9Principal Investigator

Principal Investigator

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Review Section

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立体構造から理解するRNAタクソノミPrincipal Investigator

Principal Investigator

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Elucidation of molecular mechanisms of RNA silencingPrincipal Investigator

Principal Investigator

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Research Institution

Crystal structure of the extracellular glycoprotein Enpp1Principal Investigator

Principal Investigator

Project Period (FY)

Nishimasu Hiroshi 西増弘志

NISHIMASU Hiroshi 西増弘志

[Book] 実験医学増刊シグナル伝達研究最前線2012 翻訳後修飾,解析技術,疾患との連関から創薬応用まで2012

[Book] 実験医学増刊拡大・進展を続けるRNA研究の最先端2010

[Book] 実験医学増刊拡大・進展を続けるRNA研究の最先端2010