Oh-Nishi Arata 大西新

… Alternative Names

OH-NISHI Arata 大西新

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Researcher Number	00507014
Other IDs
Affiliation (Current)	2025: 島根大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2023: 島根大学, 医学部, 客員教授 2018 – 2023: 島根大学, 学術研究院医学・看護学系, 特任教授 2017: 島根大学, 医学部, 特任教授 2016: 北里大学, 理学部, 講座研究員 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2010 – 2012: National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 2009: National Institute of Radiological Sciences, 分子神経イメージング研究グループ, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Laboratory medicine / Nerve anatomy/Neuropathology / Embryonic/Neonatal medicine Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 52030:Psychiatry-related / Psychiatric science
Keywords	Principal Investigator 統合失調症 / 免疫 / セロトニン / ビリルビン / バイオマーカー / 妊娠 / 新生児黄疸 / セロトニン伝達 / 核黄疸 / ADHD … More / 脳神経障害 / BIND / ビリルビン代謝 / モデル動物 / 治療薬 / モデルマウス / 線条体 / 前頭葉 / 術後せん妄 / 血液マーカー / 認知機能 / SAMマウス / 高齢者術後せん妄 / ＭＩＡ / 血清診断マーカー / 血液バイオマーカー / MIAモデル / 血清バイオマーカー / 精神疾患 / 発達障害 / ドーパミンD2受容体 / ドーパミン / PET / ドーパミン受容体 / ケモカイン / サイトカイン / シナプス / 海馬 / 胎児脳神経発達 / インフルエンザ感染 … More Except Principal Investigator schizophrenia / 統合失調症 / 22q11.2症候群 / バイオマーカー / 精神疾患 / 22q11.2欠失症候群 / 神経炎症 / インターニューロン / Gunn rat / bilirubin / Growth Factor / 再生医療 / ｂFGF / グロースファクター / Schizophrenia / 脳機能イメージング / 自律神経機能 / 生物学的マーカー / 児童 / スクリーニング / 早期介入 / 精神病前駆状態 / コルチゾール / バイオピリン / 児童思春期 / 発症危険状態 Less

22q11.2欠失症候群患者にみられる精神疾患発症に関するストレス脆弱性の解明
- Principal Investigator
  
  和氣玲
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Elucidation of neurological disoders in neonatal jaaundicePrincipal Investigator
- Principal Investigator
  
  Arata Oh-Nishi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Molecular pathological mechanism of schizophrenia focusing on basic fibroblast growth factor
- Principal Investigator
  
  Hayashida Maiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Shimane University
Development of treatment with postoperative delirium for elder based on pathophysiological mechanism.Principal Investigator
- Principal Investigator
  
  Oh-Nishi Arata
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Shimane University
Developing novel blood-based protein biomarker for schizophreniaPrincipal Investigator
- Principal Investigator
  
  Oh-Nishi Arata
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shimane University
  Kitasato University
  National Institute of Radiological Sciences
Development of the noninvasive screening system which aimed at the schizophrenia prophylaxis
- Principal Investigator
  
  Wake Rei
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Shimane University
Dopamine D2 receptor dysfunction in the extra-striatal region in maternal immune activation rodent modelPrincipal Investigator
- Principal Investigator
  
  OH-NISHI Arata
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Institute of Radiological Sciences
Does maternal immune activation negatively affect fetal brain neuronal development?Principal Investigator
- Principal Investigator
  
  OH-NISHI Arata
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Institute of Radiological Sciences

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] Urinary biopyrrins and free immunoglobin light chains are biomarker candidates for screening at‐risk mental state in adolescents.2022
- Author(s)
  Rei Wake, Tomoko Araki, Michiyo Fukushima, Hiroyuki Matsuda, Takuji Inagaki, Maiko Hayashida, Sadayuki Hashioka, Jun Horiguchi, Masatoshi Inagaki, Tsuyoshi Miyaoka, Arata Oh‐Nishi
- Journal Title
  
  Early Interv Psychiatry.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07864
[Journal Article] 精神疾患バイオマーカー；尿中バイオピリン2022
- Author(s)
  大西新、和氣玲、宮岡剛、稲垣正俊
- Journal Title
  
  月刊細胞
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07864
[Journal Article] ビリルビン脳症に由来する精神疾患の病態メカニズム2022
- Author(s)
  三浦章子, 宮岡剛, 稲垣正俊, 大西新
- Journal Title
  
  Bio Clinica
  
  Volume: 37 Pages: 74-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07844
[Journal Article] Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin.2021
- Author(s)
  Shoko Miura, Keiko Tsuchie, Michiyo Fukushima, Ryosuke Arauchi, Toshiko Tsumori, Koji Otsuki, Maiko Hayashida, Sadayuki Hashioka, Rei Wake, Tsuyoshi Miyaoka, Masatoshi Inagaki, Arata Oh-Nishi
- Journal Title
  
  Pediatric Research.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07864
[Journal Article] The state of oxidative stress and autonomic nervous activities in the children at risk mental state.2018
- Author(s)
  Wake R, Miyaoka T, Oh-Nishi A, Araki T, Matsuda Y, et al.
- Journal Title
  
  Neuropsychiatry
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860927
[Journal Article] How Much Can the Disease Proteomics Contribute for Overcoming Intractable Diseases?2017
- Author(s)
  大西新　前田忠計
- Journal Title
  
  Proteome Letters
  
  Volume: 2 Issue: 2 Pages: 53-58
- DOI
  10.14889/jpros.2.2_53
- NAID
  130006743389
- ISSN
  2432-2776
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08633
[Journal Article] A possible serologic biomarker for maternal immune activation-associated neurodevelopmental disorders found in the rat models.2016
- Author(s)
  Oh-Nishi A, Koga K, Maeda T, Suhara T
- Journal Title
  
  Neuroscience research
  
  Volume: 113 Pages: 63-70
- DOI
  10.1016/j.neures.2016.07.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08633
[Journal Article] Maternal immune activation by polyriboinosinic-polyribocytidilic acid injection produces synaptic dysfunction but not neuronal loss in the hippocampus of juvenile rat offspring2010
- Author(s)
  A.Oh-Nishi, S.Obayashi, I.Sugihara, T.Minamimoto, T.Suhara.
- Journal Title
  
  Brain Research
  
  Volume: 1363 Pages: 170-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791050
[Journal Article] Maternal immune activation by polyriboinosinic-polyribocytidilic acid injection produces synaptic dysfunction but not neuronal loss in the hippocampus of juvenile rat offspring.2010
- Author(s)
  A.Oh-Nishi, S.Obayashi, I.Sugihara, T.Minamimoto, T.Suhara.
- Journal Title
  
  Brain Research. 1363
  
  Pages: 170-179
- Data Source
  KAKENHI-PROJECT-21791050
[Patent] ビリルビン誘発性神経機能障害、黄疸を伴う精神疾患、又はビリルビンUDP-グルクロン酸転移酵素遺伝子変異に起因する精神疾患を治療、予防又は管理するための医薬組成物2023
- Inventor(s)
  大西新
- Industrial Property Rights Holder
  島根大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-036505
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K07844
[Patent] ビリルビン誘発性神経機能障害、黄疸を伴う精神疾患、又はビリルビンUDP-グルクロン酸転移酵素遺伝子変異に起因する精神疾患を治療、予防又は管理するための医薬組成物2023
- Inventor(s)
  大西新
- Industrial Property Rights Holder
  島根大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-21K07844
[Patent] 精神病モデル動物の作成方法2011
- Inventor(s)
  大西新、南本敬史、永井裕司、須原哲也、宮川剛、萩原英雄
- Industrial Property Rights Holder
  (独)放射線医学総合研究所、学校法人藤田学園
- Filing Date
  2011-01-18
- Overseas
- Data Source
  KAKENHI-PROJECT-21791050
[Patent] 精神病モデル動物の作成方法2011
- Inventor(s)
  大西新、南本敬史、永井裕司、須原哲也、宮川剛、萩原英雄
- Industrial Property Rights Holder
  (独)放射線医学総合研究所、学校法人藤田学園
- Filing Date
  2011-01-17
- Overseas
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] UGT1A１遺伝子変異に由来する統合失調症の新規治療薬開発2024
- Author(s)
  Arata Oh-Nishi et al.
- Organizer
  第18回統合失調症学会
- Data Source
  KAKENHI-PROJECT-21K07844
[Presentation] A novel anti-psychotic agent for Bilirubin Induced Neurological Dysfunction (BIND) associated ADHD/Schizophrenia.2023
- Author(s)
  Arata Oh-Nishi et al.
- Organizer
  第４６回日本神経科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07844
[Presentation] 精神疾患における精密医療の実現2023
- Author(s)
  Arata Oh-Nishi
- Organizer
  第33回行動薬理若手の会
- Data Source
  KAKENHI-PROJECT-21K07844
[Presentation] Precision drug discovery for schizophrenia2023
- Author(s)
  Arata Oh-Nishi et al.
- Organizer
  第97回日本薬理学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07844
[Presentation] Development of novel drug for hyperbilirubinemia induced psychiatric disorders.2020
- Author(s)
  Oh-Nishi et al
- Organizer
  日本薬理学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19680
[Presentation] MIA関連疾患（自閉症/統合失調症）血液バイオマーカー測定方法の検討2017
- Author(s)
  大西　新　前田　忠計
- Organizer
  第５7回先天異常学会
- Data Source
  KAKENHI-PROJECT-15K08633
[Presentation] 統合失調症血液マーカー候補タンパク質；遊離免疫グロブリン軽鎖（FLC）の測定法2017
- Author(s)
  大西　新　前田　忠計
- Organizer
  第１２回統合失調症学会
- Data Source
  KAKENHI-PROJECT-15K08633
[Presentation] Blood-based protein biomarker for neropsychiatric disorders with immunological dysfunction2017
- Author(s)
  Arata Oh-Nishi Tadakazu Maeda
- Organizer
  日本プロテオーム学会２０１７
- Data Source
  KAKENHI-PROJECT-15K08633
[Presentation] Free immunoglobulin light chain: a serologic biomarker candidate for maternal immune activation-associated neurodevelopmental disorders2016
- Author(s)
  Arata Oh-Nishi, Tadakazu Maeda, Tetsuya Suhara
- Organizer
  日本先天異常学会　第５６回学術集会
- Place of Presentation
  姫路商工会議所(兵庫県姫路市）
- Year and Date
  2016-07-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08633
[Presentation] Developing novel blood-based protein biomarker for schizophrenia with MIA background2016
- Author(s)
  Arata Oh-Nishi, Tadakazu Maeda, Tetsuya Suhara
- Organizer
  北米神経科学会（SFN)
- Place of Presentation
  アメリカ　サンディエゴ
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08633
[Presentation] Prenatal environmental factor and schizophrenia2015
- Author(s)
  Arata Oh-Nishi&Tetsuya Suhara
- Organizer
  日本神経科学会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08633
[Presentation] 統合失調症モデル動物: Maternal immune activation model rat における線条体外のドーパミンD2受容体機能障害の解析2012
- Author(s)
  大西新、永井裕司、南本敬史、須原哲也
- Organizer
  包括型脳科学研究推進支援ネットワーク夏のワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] 統合失調症モデル動物： Maternal immune activation model rat における線条体外のドーパミンD2受容体機能障害の解析2012
- Author(s)
  大西新
- Organizer
  包括型脳科学研究推進支援ネットワーク　夏のワークショップ
- Place of Presentation
  s仙台
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] Neuronal dysfunction in cingulate area in maternal immune activation rodent model of schizophrenia2011
- Author(s)
  Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Tetsuya Suhara
- Organizer
  Soc.Neurosci Abst..900.05(2011) 第40回北米神経科学会
- Place of Presentation
  ワシントン USA
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] A biological homology between a rodent model of maternal immune activation and schizophrenia patients: A comparative study using positron emission tomography and immune histochemistry2011
- Author(s)
  Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Tetsuya Suhara
- Organizer
  Neuroscience Research, Volume 71,Supplement S, 2011, Page e394
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] Maternal immune activation leads to schizophreniform pathology in rodent offspring :Elucidating a non-inherited schizophrenia onset mechanism2011
- Author(s)
  Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Tetsuya Suhara
- Organizer
  第32回内藤カンファレンス
- Place of Presentation
  八ヶ岳
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] Molecular imaging for motivational function and dysfunction2011
- Author(s)
  Takafumi Minamimoto, Yukiko Hori, Yuji Nagai, Arata Oh-Nishi, Tetsuya Suhar
- Organizer
  Neuroscience Research, Volume 71, Supplement S, 2011, Page e38-39
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] Alteration of dopaminergic function in a primate model of hypothyroidism revealed by PET2011
- Author(s)
  Yukiko Hori, Yuji Nagai, Arata Oh-Nishi, Tetsuya Suhara, Takafumi Minamimoto
- Organizer
  Neuroscience Research, Volume 71,Supplement S, 2011, Page e269
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] Reduction of C11-FLB 457 (dopamine D2 receptor ligand) binding in medial prefrontal cortex in mature rat with maternal immune activation2010
- Author(s)
  A.Oh-Nishi, Y.Nagai, T.Suhara, S.Obayashi
- Organizer
  北米神経科学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] Integrated approach of various discipline for understanding developmental psychiatric disorders.2010
- Author(s)
  Arata Oh-Nishi.
- Organizer
  理研GSC七夕ミーティング
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] Integrated approach of various discipline for understanding developmental psychiatric disorders2010
- Author(s)
  Arata Oh-Nishi
- Organizer
  理研GSC 七夕ミーティング
- Place of Presentation
  横浜
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] Reduction of dopmamine D2 receptor binding in medial prefrontal cortex in schizophrenia animal model with maternal immune activation.2010
- Author(s)
  Arata Oh-Nish, Yuji Nagai, Tetsuya Suhara, Shigeru Obayashi
- Organizer
  日本神経科学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] Reduction of C11-FLB 457 (dopamine D2 receptor ligand) binding in medial prefrontal cortex in mature rat with maternal immune activation.2010
- Author(s)
  A.Oh-Nishi, Y.Nagai, T.Suhara, S.Obayashi
- Organizer
  Soc.Neurosci Abst. 61.2
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] 幼若期海馬機能に対する胎生期母体免疫活性の影響2009
- Author(s)
  大西新
- Organizer
  日本神経科学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] Influence of maternal immune activation in embryonic stage on hippocampal function in juvenile stage2009
- Author(s)
  Arata Oh-Nishi, Izumi Sugihara, Tetsuya Suhara, Shigeru Obayashi.
- Organizer
  Neurosci.Res. 65 S256
- Place of Presentation
  supplement
- Data Source
  KAKENHI-PROJECT-21791050
[Presentation] A biological homology between a rodent model of maternal immune activation and schizophrenia patient: A comparative study using positron emission tomography and immune histochemistry
- Author(s)
  Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Tetsuya Suhara.
- Organizer
  第３４回日本神経科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700432
[Presentation] Neuronal dysfunction in cingulate area in maternal immune activation rodent model of schizophrenia.
- Author(s)
  Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Tetsuya Suhara.
- Organizer
  第４０回北米神経科学会
- Place of Presentation
  アメリカ（ワシントン）
- Data Source
  KAKENHI-PROJECT-23700432

1. Wake Rei (60609262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 宮岡剛 (50284047)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. Hayashida Maiko (40624747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 林田健志 (50599933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安田謙二 (00335556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 横田茂文 (50294369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Inagaki Takuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Hasegawa Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Araki Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. Tsuchie Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Oh-Nishi Arata 大西 新

OH-NISHI Arata 大西 新

Research Projects

Research Products

Co-Researchers

22q11.2欠失症候群患者にみられる精神疾患発症に関するストレス脆弱性の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of neurological disoders in neonatal jaaundicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular pathological mechanism of schizophrenia focusing on basic fibroblast growth factor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of treatment with postoperative delirium for elder based on pathophysiological mechanism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing novel blood-based protein biomarker for schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the noninvasive screening system which aimed at the schizophrenia prophylaxis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dopamine D2 receptor dysfunction in the extra-striatal region in maternal immune activation rodent modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Does maternal immune activation negatively affect fetal brain neuronal development?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Urinary biopyrrins and free immunoglobin light chains are biomarker candidates for screening at‐risk mental state in adolescents.2022

Author(s)

Journal Title

Data Source

[Journal Article] 精神疾患バイオマーカー；尿中バイオピリン2022

Author(s)

Journal Title

Data Source

[Journal Article] ビリルビン脳症に由来する精神疾患の病態メカニズム2022

Author(s)

Journal Title

Data Source

[Journal Article] Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin.2021

Author(s)

Journal Title

Data Source

[Journal Article] The state of oxidative stress and autonomic nervous activities in the children at risk mental state.2018

Author(s)

Journal Title

Data Source

[Journal Article] How Much Can the Disease Proteomics Contribute for Overcoming Intractable Diseases?2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Oh-Nishi Arata 大西新

OH-NISHI Arata 大西新

[Patent] ビリルビン誘発性神経機能障害、黄疸を伴う精神疾患、又はビリルビンUDP-グルクロン酸転移酵素遺伝子変異に起因する精神疾患を治療、予防又は管理するための医薬組成物2023