MIZUKAMI Shusaku 水上修作

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SHUSAKU Mizukami 水上修作

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Researcher Number	00508971
Other IDs	https://orcid.org/0000-0002-7722-4884
Affiliation (Current)	2025: 長崎大学, 熱帯医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 長崎大学, 熱帯医学研究所, 准教授 2016 – 2018: 長崎大学, 熱帯医学研究所, 助教 2012 – 2013: 岡山大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Tumor immunology Except Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 90120:Biomaterials-related / Parasitology (including sanitary zoology)
Keywords	Principal Investigator 抗原提示 / 細胞性免疫 / デング熱 / ワクチン / エピトープ / タンパク質分解 / 免疫 / dendritic cells / liver cells / protein processing … More / dengue / iPS cell / マウスモデル / 感染防御 / デングウイルス / 組換えマウス / 樹状細胞 / iPS細胞 / クロスプレゼンテーション / heat shock protein / 細胞膜表面 / モノクローナル抗体 / アジュバント / 抗原提示細胞 / 抗体 / 熱ショックタンパク質 … More Except Principal Investigator 遺伝子発現解析 / 回復期 / 急性期 / シングルセル解析 / T細胞受容体 / メモリー細胞 / エフェクター細胞 / シングルセルｍRNA発現解析 / T 細胞レパトワ解析 / T細胞レセプター遺伝子 / 重症型デング熱 / 細胞障害性T細胞 / ヒト免疫応答性 / ワクチン開発 / デング熱 / mRNA / ワクチン / 多色深部イメージング / 標的指向化 / ドラッグデリバリーシステム / 主要組織適合抗原 / ゲノム / 感染症 / 免疫学 / 次世代シークエンシング / HLA / 次世代シークエンサー / 無症候性マラリア / マラリア / フィリピン / ケニア / 抗原変異 / 多型性 / マラリアワクチン / HLA遺伝子 / 無症候性 / 熱帯熱マラリア Less

Development of innovative T cell-inducing vaccine drug based on mRNA delivery
- Principal Investigator
  
  Kawakami Shigeru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nagasaki University
Single cell analysis of TCR genotypes of CTL at recovery phase of acute Dengue infection
- Principal Investigator
  
  Hirayama Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Fundamental analysis based on protein processing for dengue vaccine developmentPrincipal Investigator
- Principal Investigator
  
  Mizukami Shusaku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Antigenic variation can change T cell immunity in malaria?
- Principal Investigator
  
  HIRAYAMA Kenji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Nagasaki University
Analysis of cellular immunity on dengue infected HLA transgenic mousePrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Shusaku
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagasaki University
Newly vaccine strategy with mAbs against heat shock protein 90 (HSP90) on surface of antigen presenting cell (APC)Principal Investigator
- Principal Investigator
  
  SHUSAKU Mizukami
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Okayama University

All 2023 2022 2021 2019 2018 2017 2016 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice2023
- Author(s)
  Kawaguchi Maho、Noda Marin、Ono Akari、Kamiya Mariko、Matsumoto Makoto、Tsurumaru Masako、Mizukami Shusaku、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 112 Issue: 5 Pages: 1401-1410
- DOI
  10.1016/j.xphs.2022.12.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03818
[Journal Article] Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability2022
- Author(s)
  Kamiya Mariko、Matsumoto Makoto、Yamashita Kazuma、Izumi Tatsunori、Kawaguchi Maho、Mizukami Shusaku、Tsurumaru Masako、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 11 Pages: 2357-2357
- DOI
  10.3390/pharmaceutics14112357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03818
[Journal Article] iPS cell serves as a source of dendritic cells for in vitro dengue virus infection model2018
- Author(s)
  Manh Dao Huy、Mizukami Shusaku、Dumre Shyam Prakash、Raekiansyah Muhareva、Senju Satoru、Nishimura Yasuharu、Karbwang Juntra、Huy Nguyen Tien、Morita Kouichi、Hirayama Kenji
- Journal Title
  
  Journal of General Virology
  
  Volume: 99 Issue: 9 Pages: 1239-1247
- DOI
  10.1099/jgv.0.001119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-16K15519
[Presentation] mRNA封入脂質ナノ粒子の安定性、物理化学的性質、タンパク質発現の相関の評価2022
- Author(s)
  神谷万里子, 松本眞, 川口真帆, 水上修作, 向井英史, 川上茂
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] 筋肉内投与における脂質ナノ粒子コレステロール含有量のタンパク発現分布への影響2022
- Author(s)
  川口真帆, 小野亜佳莉, 神谷万里子, 水上修作, 向井英史, 川上茂
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] Luciferase mRNA封入脂質ナノ粒子の保存安定性に関する研究2021
- Author(s)
  神谷万里子, 川口真帆, 小野亜佳莉, 鶴丸雅子, 水上修作, 向井英史, 川上茂
- Organizer
  日本薬剤学会第2回超分子薬剤学FGシンポジウム
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] Genomic diversity of the human malaria parasite Plasmodium falciparum, isolated from a domestic population of Palawan Island, Philippines.2019
- Author(s)
  Naruse TK, Methenge P G, Narahara C, Benedicte MM, Avenido EF, Mercado ES, Espino F E, Jiz M, Mizukami S, Tanimoto K, Kimura A, Hirayama K.
- Organizer
  Awaji International Conference on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04072
[Presentation] Discovery of novel antimalarial(s) using high throughput screening and combinational chemistry2018
- Author(s)
  Farhana Mosaddeque, Shusaku Mizukami, Awet A Teklemichael, Satoshi Mizuta, Yoshimasa Tanaka, Mayumi Taniguchi, Michiko Fukuda, Nobuyuki Kobayashi, Nguyen T Huy, Kenji Hirayama
- Organizer
  WCP2018 KYOTO 第18回国際薬理学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04072
[Presentation] iPS cell serves as a source of dendritic cells for in vitro dengue virus infection model.2018
- Author(s)
  Shusaku Mizukami, Dao Huy Manh, Shyam P Dumre, Muhareva Raekiansyah, Satoru Senju, Yasuharu Nishimura, Juntra Karbwang, Nguyen T Huy, Kouichi Morita, Kenji Hirayama.
- Organizer
  第47回日本免疫学会総会・学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15519
[Presentation] Discovery of novel antimalarial(s) from hemozoin inhibitors2018
- Author(s)
  Farhana Mosaddeque, Mizukami Shusaku, Teklemichael Awet Alem, Mizuta Satoshi, Tanaka Yoshimasa, Taniguchi Mayumi, Fukuda Michiko, Huy Nguyen Tien, HIrayama Kenji
- Organizer
  第59回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-17H04072
[Presentation] iPS cell derived dendritic cell like cell is infected with dengue virus, and acts as antigen presenting cell.2017
- Author(s)
  Shusaku Mizukami, Dao Huy Manh, Muhareva Raekiansyah, Shyam Prakash Dumre, Satoru Senju, Yasuharu Nishimura, Juntra Karbwang Laothavorn, Kouichi Morita, Kenji Hirayama.
- Organizer
  Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15519
[Presentation] iPS cell derived dendritic cell can be a good host of dengue virus.2016
- Author(s)
  Mizukami S, Manh DH, Raekiansyah M, Dumre SP, Senju S, Morita K, Hirayama K.
- Organizer
  The 64th Annual Meetings of the Japanese Society for Virology
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16K15519
[Presentation] iPS cell derived dendritic cell can be a good host of dengue virus.2016
- Author(s)
  Mizukami S, Manh DH, Raekiansyah M, Dumre SP, Senju S, Morita K, Hirayama K.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K15519
[Presentation] Newly vaccine strategy with mAbs against heat shock protein 90 (HSP90) on surface of antigen presenting cell (APC).2013
- Author(s)
  水上修作、岡山容子、山崎千尋、鵜殿平一郎
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] 抗原提示細胞膜表面hsp90を標的としたmAbを用いたワクチン開発の基盤的研究2013
- Author(s)
  水上修作, 他
- Organizer
  第17回日本がん免疫学会学術集会・総会
- Place of Presentation
  山口
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] Newly vaccine strategy with mAbs against heat shock protein 90 (HSP90) on surface of antigen presenting cell (APC)2013
- Author(s)
  水上修作, 他
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] 抗原提示細胞膜表面HSP90を標的としたmAbを用いたワクチン開発の基盤的研究2013
- Author(s)
  水上修作、山﨑千尋、岡山容子、鵜殿平一郎
- Organizer
  第17回　日本がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] 抗原提示細胞膜表面hsp90を標的としたmAbを用いたワクチン開発の基盤的研究2012
- Author(s)
  水上修作, 他
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] 抗原提示細胞膜表面hsp90を標的としたmAbを用いたワクチン開発の基盤的研究2012
- Author(s)
  水上修作, 他
- Organizer
  第16回日本がん免疫学会学術集会・総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] 抗原提示細胞膜表面hsp90を標的としたmAbワクチン開発の基盤的研究
- Author(s)
  水上修作、山崎千尋、鵜殿平一郎
- Organizer
  第71回　日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24700992
[Presentation] 抗原提示細胞膜表面hsp90を標的としたmAbを用いたワクチン開発の基盤的研究
- Author(s)
  水上修作、山崎千尋、鵜殿平一郎
- Organizer
  第16回日本がん免疫学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24700992
[]

1. HIRAYAMA Kenji (60189868)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Kawakami Shigeru (20322307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 向井英史 (60570885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. グエンフイティエン (20457526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 谷本幸介 (60611613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. DAO Huy Manh

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. DUMRE Shyam Prakash

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. RAEKIANSYAH Muhareva

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. SENJU Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. NISHIMURA Yasuharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. KARBWANG Laothavorn Juntra

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. HUY Nguyen Tien

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. MORITA Kouichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. 西村康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUKAMI Shusaku 水上 修作

SHUSAKU Mizukami 水上 修作

Research Projects

Research Products

Co-Researchers

Development of innovative T cell-inducing vaccine drug based on mRNA delivery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single cell analysis of TCR genotypes of CTL at recovery phase of acute Dengue infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental analysis based on protein processing for dengue vaccine developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Antigenic variation can change T cell immunity in malaria?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cellular immunity on dengue infected HLA transgenic mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Newly vaccine strategy with mAbs against heat shock protein 90 (HSP90) on surface of antigen presenting cell (APC)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS cell serves as a source of dendritic cells for in vitro dengue virus infection model2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] mRNA封入脂質ナノ粒子の安定性、物理化学的性質、タンパク質発現の相関の評価2022

Author(s)

Organizer

Data Source

[Presentation] 筋肉内投与における脂質ナノ粒子コレステロール含有量のタンパク発現分布への影響2022

Author(s)

Organizer

Data Source

[Presentation] Luciferase mRNA封入脂質ナノ粒子の保存安定性に関する研究2021

Author(s)

Organizer

Data Source

[Presentation] Genomic diversity of the human malaria parasite Plasmodium falciparum, isolated from a domestic population of Palawan Island, Philippines.2019

Author(s)

Organizer

Data Source

[Presentation] Discovery of novel antimalarial(s) using high throughput screening and combinational chemistry2018

Author(s)

Organizer

Data Source

[Presentation] iPS cell serves as a source of dendritic cells for in vitro dengue virus infection model.2018

Author(s)

Organizer

Data Source

MIZUKAMI Shusaku 水上修作

SHUSAKU Mizukami 水上修作