Dan Takashi 段孝

… Alternative Names

DAN Takashi 段孝

Less

Researcher Number	00512451
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2018: 東北大学, 医学系研究科, 准教授 2014: 東北大学, 医学系研究科, 准教授
Review Section/Research Field	Principal Investigator Health science and related fields Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator 発現制御 / TGF-β1 / SASP(細胞老化関連分泌形質) / 転写制御 / TGFβ / マクロファージ / 老化 / SASP / LPS / TNFα / PAI-1 / 老化制御 … More Except Principal Investigator … More 生体分子 / 生理活性 / 薬理学 Less

Elucidation of the new control mechanism of aging through PAI-1Principal Investigator
- Principal Investigator
  
  Dan Takashi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  Tohoku University
The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseases
- Principal Investigator
  
  MIYATA Toshio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University

All 2018 2015 2014 2013

All Journal Article

[Journal Article] Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-12018
- Author(s)
  Kawaguchi Shin-Ichi, Gonda Yuhei, Yamamoto Takuya, Sato Yuki, Shinohara Hiroyuki, Kobiki Yohsuke, Ichimura Atsuhiko, Dan Takashi, Sonoda Motohiro, Miyata Toshio, Ogawa Akiya, Tsujita Tadayuki
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 4 Pages: 885-885
- DOI
  10.3390/molecules23040885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04138, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-16K14049, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17K19881
[Journal Article] New direction of PAI-1 inhibitor development: Clinical application to cancer treatment2018
- Author(s)
  DAN Takashi、UCHIDA Wataru、HIRATSUKA Hideaki、OSHIMA Yoshiteru、MIYATA Toshio
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 29 Issue: 5 Pages: 487-494
- DOI
  10.2491/jjsth.29.487
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17K19881
[Journal Article] Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives2018
- Author(s)
  Yamaoka Nagahisa、Murano Kenji、Kodama Hidehiko、Maeda Akihisa、Dan Takashi、Nakabayashi Tetsuo、Miyata Toshio、Meguro Kanji
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 4 Pages: 809-813
- DOI
  10.1016/j.bmcl.2017.11.016
- Data Source
  KAKENHI-PROJECT-17K19881
[Journal Article] Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.2015
- Author(s)
  Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N.
- Journal Title
  
  Cancer Biol Ther.
  
  Volume: 16 Pages: 253-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and　Axonal Degeneration in a Mice Model of Multiple Sclerosis2015
- Author(s)
  Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele C, Miyata T.
- Journal Title
  
  PLoS One.
  
  Volume: 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis.2015
- Author(s)
  Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 308・6 Issue: 6 Pages: F614-F626
- DOI
  10.1152/ajprenal.00616.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-25461617, KAKENHI-PROJECT-23249047
[Journal Article] Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration.2014
- Author(s)
  Ibrahim AA, Yahata T, Onizuka M, Dan T, van Ypersele de Strihou C, Miyata T, Ando K.
- Journal Title
  
  Stem Cells
  
  Volume: 32 Pages: 946-958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249033
[Journal Article] TM5275prolongs secreted tissue plasminogen activator retention and enhancesfibrinolysis on vascular endothelial cells.2013
- Author(s)
  Yasui H, Suzuki Y, Sano H, Suda T, Chida K, Dan T, Miyata T, Urano T
- Journal Title
  
  Thromb Res
  
  Volume: ## Issue: 1 Pages: 100-105
- DOI
  10.1016/j.thromres.2013.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590826, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-24590273, KAKENHI-PROJECT-25461123
[Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.2013
- Author(s)
  Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou S, Miyata T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 33 Issue: 5 Pages: 935-942
- DOI
  10.1161/atvbaha.113.301224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590219, KAKENHI-PROJECT-23890019, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487

1. MIYATA Toshio (10222332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. ICHIMURA Atsuhiko (10609209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SUZUKI Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. URANO Tetsumei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 小川昭弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 松尾理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岡田清孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松阪泰二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. PASTAN Ira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Dan Takashi 段 孝

DAN Takashi 段 孝

Research Projects

Research Products

Co-Researchers

Elucidation of the new control mechanism of aging through PAI-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-12018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New direction of PAI-1 inhibitor development: Clinical application to cancer treatment2018

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.2015

Author(s)

Journal Title

Data Source

[Journal Article] Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis2015

Author(s)

Journal Title

Data Source

[Journal Article] Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration.2014

Author(s)

Journal Title

Data Source

[Journal Article] TM5275prolongs secreted tissue plasminogen activator retention and enhancesfibrinolysis on vascular endothelial cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.2013

Author(s)

Journal Title

DOI

Data Source

Dan Takashi 段孝

DAN Takashi 段孝

[Journal Article] Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and　Axonal Degeneration in a Mice Model of Multiple Sclerosis2015