HIYAMA AKIHIKO 檜山明彦

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HIYAMA Akihiko 檜山明彦

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Researcher Number	00514382
Other IDs	https://orcid.org/0000-0002-2474-9118
Affiliation (Current)	2026: 東海大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 東海大学, 医学部, 准教授 2013 – 2019: 東海大学, 医学部, 講師 2012 – 2013: 東海大学, 医学部, 助教 2009 – 2010: Tokai University, 医学部, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 椎間板変性 / Wntシグナル / 腰痛 / 腰痛の解明 / 分子学的解析 / 脊椎脊髄病学 / 新規抗炎症メカニズム / IL-37 / 腰痛治療 / 腰痛治療薬 … More / 転写制御 / ＮＧＦ / 神経栄養因子 / Ｗｎｔシグナル / Cell signaling / ＣＣＮ　family / CCL20 / CCR6 / CCN family / NGF / 炎症性サイトカイン / ケモカイン / 創薬 / 分子学的研究 / ＥＰ受容体 / Ｗｎｔｼｸﾞﾅﾙ / ﾌﾟﾛｽﾀﾉｲﾄﾞ / NF-κβ / 椎間板細胞 / EP受容体 / TNF－α / PGE2 / Wnt シグナル / Wntｼｸﾞﾅﾙ / VEGF / カルシウムシグナル / TonEBP / Intervertebral disc / NFAT / BMP2 / TGF-β / intervertebral disc / GlcAT-I … More Except Principal Investigator 再生医学 / 再生医療 / 椎間板 / 創薬 / iPS細胞技術 / 脊椎脊髄病学 / 整形外科学 / 凍結保存 / 同種細胞移植 / 移植・再生医療 / iPS細胞 / インシリコ創薬 / iPS技術 / 転写因子 / 腰痛 / 椎間板再生 / 髄核細胞 / 椎間板変性 / 線維輪細胞 / 線維輪 / 幹細胞 Less

Elucidation of a novel anti-inflammatory mechanism for treating low back pain by targeting IL-37Principal Investigator
- Principal Investigator
  
  檜山明彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokai University
Analysis of transcription factors mediated by Wnt signal in intervertebral disc degeneration and search for therapeutic agents for low back painPrincipal Investigator
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Analysis of molecular mechanism of Wnt signal and arachidonic acid cascade in intervertebral disc degenerationPrincipal Investigator
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Analysis of appropriate cell source for efficient annulus fibrosis regeneration
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Pathogenesis of intervertebral disc degeneration and functional analysis of vascular endothelial growth factor (VEGF) in the intervertebral discPrincipal Investigator
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Molecular mechanisms involved in intervertebraldisc degeneration and potential new treatment strategiesPrincipal Investigator
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University

All 2019 2017 2016 2015 2013 2012 2010 Other

All Journal Article Presentation

[Journal Article] Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro2019
- Author(s)
  Nukaga Tadashi、Sakai Daisuke、Schol Jordy、Suyama Kaori、Nakai Tomoko、Hiyama Akihiko、Watanabe Masahiko
- Journal Title
  
  Spine Surgery and Related Research
  
  Volume: 3 Issue: 4 Pages: 385-391
- DOI
  10.22603/ssrr.2019-0019
- NAID
  130007734403
- ISSN
  2432-261X
- Year and Date
  2019-10-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells.2015
- Author(s)
  Hiyama A
- Journal Title
  
  J Orthop Res
  
  Volume: 33 Issue: 12 Pages: 1756-1768
- DOI
  10.1002/jor.22959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462252
[Journal Article] C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells2013
- Author(s)
  Yokoyama K1, Hiyama A, Arai F, Nukaga T, Sakai D, Mochida J
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 9 Pages: e73210-e73210
- DOI
  10.1371/journal.pone.0073210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells.2013
- Author(s)
  Akihiko Hiyama
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791570
[Journal Article] Cell Signaling Pathways Related to Pain Receptors in the Degenerated Disk2013
- Author(s)
  Hiyama A, Sakai D, Mochida J
- Journal Title
  
  Global Spine Journal
  
  Volume: 3 Pages: 165-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.2012
- Author(s)
  Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J.
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 14 Issue: 3
- DOI
  10.1186/ar3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] The expression and role of non-canonical(PKC) signaling in nucleus pulposus cell metabolism2012
- Author(s)
  Arai F, Hiyama A, Sakai D, Yokoyama K, Mochida J
- Journal Title
  
  J Orthop Res
  
  Volume: 30(In press) Issue: 9 Pages: 1478-85
- DOI
  10.1002/jor.22095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406, KAKENHI-PROJECT-24592213
[Journal Article] The effects of oxygen tension and antiaging factor Klotho on the Wnt singaling in nucleus pulposus cells.2012
- Author(s)
  Akihiko Hiyama
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791570
[Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012
- Author(s)
  Abe, K. et al.
- Journal Title
  
  Genesis
  
  Volume: 50 Issue: 10 Pages: 758-765
- DOI
  10.1002/dvg.22035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-22500392, KAKENHI-PROJECT-22791388, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23592892, KAKENHI-PROJECT-23593038, KAKENHI-PROJECT-23700562, KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-24592213, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-24115712
[Journal Article] BMP-2 and TGFbeta Stimulate Expression of beta1,3 Glucuronosyl Transferase-1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP and Sp1 : Role of Map Kinases.2010
- Author(s)
  Hiyama A
- Journal Title
  
  Journal of Bone Miner Res
  
  Volume: 25(5) Pages: 1179-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791419
[Journal Article] BMP-2 and TGFbeta Stimulate Expression of beta1,3 Glucuronosyl Transferase-I (G1cAT-I) in Nucleus Pulposus Cells Through AP1, TonEBP and Sp1 : Role of Map Kinases
- Author(s)
  Hiyama A, et al
- Journal Title
  
  Journal of Bone Miner Res 25(5)
  
  Pages: 1179-1190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791419
[Presentation] CCAAT/enhancer binding protein β Regulates the Expression of Tumor Necrosis Factor-α in the Nucleus Pulposus Cells2017
- Author(s)
  Akihiko Hiyama
- Organizer
  ORS 2017 Annual Meeting
- Place of Presentation
  San Diego Convention Center （アメリカ・San Diego）
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462252
[Presentation] 椎間板細胞を用いたＷｎｔシグナルによるＣＣＮｆａｍｉｌｙの機能解析2017
- Author(s)
  檜山明彦
- Organizer
  第32回　日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K10945
[Presentation] 椎間板変性におけるWntシグナル伝達経路の活性制御と椎間板炎症2016
- Author(s)
  檜山明彦
- Organizer
  第3１回日本整形外科基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462252
[Presentation] TGF-β/BMPシグナルはAP-1,TonEBPを介し椎間板内硫酸化グリコサミノグリカン代謝に関与する2010
- Author(s)
  檜山明彦
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21791419
[Presentation] 炎症性ｻｲﾄｶｲﾝTNFαはNFκβとCOX-2/PGE2 経路を介しWntｼｸﾞﾅﾙを発現制御する
- Author(s)
  檜山　明彦
- Organizer
  第29回　日本整形外科基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26462252

1. SAKAI Daisuke (10408007)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. MOCHIDA Joji (30129697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NAKAI Tomoko (20624589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平山令明 (70238393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 升井伸治 (20342850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIYAMA AKIHIKO 檜山 明彦

HIYAMA Akihiko 檜山 明彦

Research Projects

Research Products

Co-Researchers

Elucidation of a novel anti-inflammatory mechanism for treating low back pain by targeting IL-37Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of transcription factors mediated by Wnt signal in intervertebral disc degeneration and search for therapeutic agents for low back painPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular mechanism of Wnt signal and arachidonic acid cascade in intervertebral disc degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of appropriate cell source for efficient annulus fibrosis regeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis of intervertebral disc degeneration and functional analysis of vascular endothelial growth factor (VEGF) in the intervertebral discPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms involved in intervertebraldisc degeneration and potential new treatment strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells.2013

Author(s)

Journal Title

Data Source

[Journal Article] Cell Signaling Pathways Related to Pain Receptors in the Degenerated Disk2013

Author(s)

Journal Title

Data Source

[Journal Article] The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The expression and role of non-canonical(PKC) signaling in nucleus pulposus cell metabolism2012

HIYAMA AKIHIKO 檜山明彦

HIYAMA Akihiko 檜山明彦

[Presentation] 椎間板細胞を用いたＷｎｔシグナルによるＣＣＮｆａｍｉｌｙの機能解析2017