Sekine Yoshitaka 関根芳岳

… Alternative Names

SEKINE Yoshitaka 関根芳岳

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Researcher Number	00516370
Other IDs	https://orcid.org/0000-0002-8094-4524
Affiliation (Current)	2024: 群馬大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 群馬大学, 大学院医学系研究科, 講師 2016 – 2018: 群馬大学, 大学院医学系研究科, 助教 2011 – 2015: 群馬大学, 医学(系)研究科(研究院), 助教 2013: 群馬大学, 医学系研究科, 助教 2011 – 2012: 群馬大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Urology / Basic Section 56030:Urology-related Except Principal Investigator Urology
Keywords	Principal Investigator スタチン / 前立腺癌 / 脂質 / 神経内分泌分化 / 前立腺癌神経内分泌分 / 脂質代謝 / 前立腺癌神経内分泌 / シスプラチン / オラパリブ / 去勢抵抗性前立腺癌 … More / プラチナ製剤 / PARP阻害剤 / トランスレーショナルリサーチ / 癌 / DNA修復 / PAPR阻害剤 / 重粒子 / 放射線 / NSAIDs / AKR1C3 / データベース / miRNA / 腫瘍学 … More Except Principal Investigator 脂質代謝 / 脂質 / 前立腺癌 / 質量分析 / ステロイド代謝 / イメージング質量分析 / ステロイド / スタチン / 副腎性アンドロゲン Less

神経内分泌細胞分化前立腺癌における脂質代謝を介した増殖メカニズムの基礎的検討Principal Investigator
- Principal Investigator
  
  関根芳岳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Gunma University
Combination therapy of PARP inhibitor, statin and platinum-containing drug for prostate cancerPrincipal Investigator
- Principal Investigator
  
  Sekine Yoshitaka
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Gunma University
Combination therapy with X-ray or heavy ion therapy and statin for prostate cancerPrincipal Investigator
- Principal Investigator
  
  Sekine Yoshitaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Gunma University
Lipid and steroid metabolism and prostate cancer using imaging mass-spectrometry
- Principal Investigator
  
  Suzuki Kazuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Gunma University
Effect of statins on de novo steroid synthesis pathways in androgen independent prostate cancer cells.Principal Investigator
- Principal Investigator
  
  YOSHITAKA Sekine
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Gunma University
The role of lipid metabolism in prostate cancer
- Principal Investigator
  
  SUZUKI Kazuhiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Gunma University
The effects of statin on prostate cancer progression via miRNAPrincipal Investigator
- Principal Investigator
  
  SEKINE Yoshitaka
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Gunma University

All 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Simvastatin in combination with meclofenamic acid inhibits the proliferation and migration of human prostate cancer PC-3 cells via an AKR1C3 mechanism.2018
- Author(s)
  Sekine Y, Nakayama H, Miyazawa Y, Kato H, Furuya Y, Arai S, Koike H, Matsui H, Shibata Y, Ito K, Suzuki K.
- Journal Title
  
  Oncology Letters
  
  Volume: 15 Pages: 3167-3172
- DOI
  10.3892/ol.2017.7721
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04971
[Journal Article] Simvastatin Up-Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen-Independent Human Prostate Cancer Cells.2017
- Author(s)
  Miyazawa Y, Sekine Y, Kato H, Furuya Y, Koike H, Suzuki KSimvastatin Up-Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen-Independent Human Prostate Cancer Cells.
- Journal Title
  
  The Prostate
  
  Volume: 77 Issue: 4 Pages: 337-349
- DOI
  10.1002/pros.23273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04971
[Journal Article] Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content.2017
- Author(s)
  Shibata Y, Arai S, Miyazawa Y, Shuto T, Nomura M, Sekine Y, Koike H, Matsui H, Ito K, Suzuki K.
- Journal Title
  
  The Prostate
  
  Volume: 72 Issue: 6 Pages: 672-688
- DOI
  10.1002/pros.23315
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04971
[Journal Article] Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins.2016
- Author(s)
  Furuya Y, Sekine Y, Kato H, Miyazawa Y, Koike H, Suzuki K.
- Journal Title
  
  doi: 10.1016/j.prnil.2016.02.003.
  
  Volume: 4 Issue: 2 Pages: 56-60
- DOI
  10.1016/j.prnil.2016.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04971
[Journal Article] Development of prostate cancer in a patient with primary hypogonadism : intratumoural steroidogenesis in prostate cancer tissues2013
- Author(s)
  Arai S, Shibata Y, Nakamura Y, Kashiwagi B, Uei T, Tomaru Y, Miyashiro Y, Honma S, Hashimoto K, Sekine Y, Ito K, Sasano H, Suzuki K
- Journal Title
  
  Andrology
  
  Volume: 1(1) Pages: 169-74
- NAID
  120005624156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Diagnostic significance of [-2]pro-PSA and prostate dimension-adjusted PSA-related indices in men with total PSA in the 2.0-10.0 ng/mL range2013
- Author(s)
  Ito K, Miyakubo M, Sekine Y, Koike H, Matsui H, Shibata Y, Suzuki K
- Journal Title
  
  World J Urol
  
  Volume: 31(2) Pages: 305-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Androgen receptor coactivator p120 subtype β is highly expressed in prostate cancer2013
- Author(s)
  Muramatsu K, Matsui H, Sekine Y, Koike H, Shibata Y, Ito K, Suzuki K
- Journal Title
  
  Prostate Int
  
  Volume: 1(1) Pages: 10-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Rapamycin enhances docetaxel-induced cytotoxicity in a androgen-independent prostate cancer xenograft model by survivin downregulation2012
- Author(s)
  Morikawa Y, Koike H, Sekine Y, Matsui H, Shibata Y, Ito K, Suzuki K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419(3) Pages: 584-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Development and external validation of a nomogram for predicting cancer probability at initial prostate biopsy using the life expectancy-and prostate volume-adjusted biopsy scheme2012
- Author(s)
  Nomura M, Ito K, Miyakubo M, Sekine Y, Tamura Y, Shimizu N, Aoki S, Suzuki K
- Journal Title
  
  Prostate Cancer Prostatic Dis
  
  Volume: 15(2) Pages: 202-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Luteinizing hormone (LH)-releasing hormone agonist reduces serum adrenal androgen levels in prostate cancer patients : implications for the effect of LH on the adrenal glands2012
- Author(s)
  Nishii M, Nomura M, Sekine Y, Koike H, Matsui H, Shibata Y, Ito K, Oyama T, Suzuki K
- Journal Title
  
  J Androl
  
  Volume: 33(6) Pages: 1233-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Role of squalene synthase in prostate cancer risk and the biological aggressiveness on human prostate cancer2012
- Author(s)
  Y Fukuma, H Matsui, H Koike, Y Sekine, I Shechter, N Ohtake, S Nakata, K Ito, K Suzuki
- Journal Title
  
  Prostate Cancer and Prostatic Disease
  
  Volume: 15 Issue: 6 Pages: 339-345
- DOI
  10.2164/jandrol.112.016493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Journal Article] Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer2012
- Author(s)
  Fukuma Y, Matsui H, Koike H, Sekine Y, Shechter I, Ohtake N, Nakata S, Ito K, Suzuki K
- Journal Title
  
  Prostate Cancer Prostatic Dis
  
  Volume: 15(4) Pages: 339-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] Combination therapy with PARP inhibitor and statin for castration-resistant and taxane-resistant prostate cancer2019
- Author(s)
  Yoshitaka Sekine
- Organizer
  114th AUA Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10995
[Presentation] DNA修復遺伝子群を介したスタチンとPARP阻害剤の併用による去勢抵抗性前立腺癌細胞増殖抑制効果の解明2019
- Author(s)
  関根芳岳
- Organizer
  第107回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-16K10995
[Presentation] AKR1C3を介したスタチンとNSAIDsの併用効果による前立腺癌細胞進展抑制効果の解明2015
- Author(s)
  関根芳岳、古谷洋介、加藤春雄、宮澤慶行、新井誠二、新田貴士、小池秀和、松井博、柴田康博、伊藤一人、鈴木和浩
- Organizer
  第103回日本泌尿器科学会総会
- Place of Presentation
  金沢市
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-25861410
[Presentation] Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor2014
- Author(s)
  Kato H, Sekine Y, Miyazawa Y, Syuto T, Furuya Y, Matsui H, Koike H, Suzuki K
- Organizer
  4th Asian Pacific Prostatic Society
- Place of Presentation
  名護市
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] Statin inhibits Progression of Human Prostate Androgen Independent Cancer Cells via Regulating miRNA Expressions2014
- Author(s)
  Sekine Y, Furuya Y, Kato H, Miyazawa Y, Syuto T, Arai S, Nitta T, Koike H, Matsuhi H, Shibata Y, Ito K, Suzuki K
- Organizer
  4th Asian Pacific Prostatic Society
- Place of Presentation
  名護市
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor2014
- Author(s)
  Kato H, Sekine Y, Miyazawa Y, Furuya Y, Koike H, Suzuki K
- Organizer
  AACR Prostate cancer meeting
- Place of Presentation
  San Diego
- Year and Date
  2014-01-19
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] LH-RHアゴニストによる前立腺癌患者の血清副腎性アンドロゲン濃度の低下 : LHの副腎に対する作用への影響2013
- Author(s)
  西井昌弘, 野村昌史, 関根芳岳, 小池秀和, 松井博, 柴田康博, 羽鳥基明, 伊藤一人, 鈴木和浩, 小山徹也
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌市
- Year and Date
  2013-04-28
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] ホルモン不応性前立腺癌における, スタチンによる腫瘍内アンドロゲン de novo合成への影響の解明2013
- Author(s)
  関根芳岳, 古谷洋介, 加藤春雄, 宮澤慶行, 新井誠二, 村松和道, 新田貴士, 小池秀和, 松井博, 柴田康博, 伊藤一人, 鈴木和浩
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌市
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] アンドロゲンレセプターコアクチベーターp120のサブタイプβは前立腺癌で高発現する2013
- Author(s)
  村松和道, 松井博, 関根芳岳, 小池秀和, 柴田康博, 伊藤一人, 羽鳥基明, 野村昌史, 新田貴士
- Organizer
  101回日本泌尿器科学会総会
- Place of Presentation
  札幌市
- Year and Date
  2013-04-26
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] ホルモン不応性前立腺癌における、スタチンによる腫瘍内アンドロゲンde novo合成への影響の解明2013
- Author(s)
  関根芳岳
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25861410
[Presentation] スタチンによるmiRNAを介した前立腺癌増殖制御機構の解明2012
- Author(s)
  関根芳岳
- Organizer
  第28回前立腺シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791741
[Presentation] スタチンによるmiRNAを介した前立腺癌増殖制御機構の解明2012
- Author(s)
  関根芳岳、古谷洋介、加藤春雄、宮澤慶行、新井誠二、村松和道、新田貴士、小池秀和、松井博、柴田康博、伊藤一人、鈴木和浩
- Organizer
  第28回前立腺シンポジウム
- Place of Presentation
  東京コンファレンスセンター
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-23791741
[Presentation] Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor
- Author(s)
  Haruo Kato , Yoshitaka Sekine , Yoshiyuki Miyazawa , Yosuke Furuya , Hidekazu Koike , Kazuhiro Suzuki
- Organizer
  American Association Cancer Research-Prostate Cancer Foundation Conference Advances in Prostate Cancer Research
- Place of Presentation
  サンデイエゴ、米国
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor
- Author(s)
  Haruo Kato, Yoshitaka Sekine, Yoshiyuki Miyazawa, Takahiro Syuto, Yosuke Furuya, Hiroshi Matsui, Hidekazu Koike, Kazuhiro Suzuki
- Organizer
  Asian Pacific Prostate Society 2014
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] ホルモン不応性前立腺癌における、スタチンによる腫瘍内アンドロゲンde novo合成への影響の解明
- Author(s)
  関根芳岳、古谷洋介、加藤春雄、宮澤慶行、新井誠二、村松和道、新田貴士、小池秀和、松井　博、柴田康博、伊藤一人、鈴木和浩
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] Statin inhibits Progression of Human Prostate Androgen Independent Cancer Cells via Regulating miRNA Expressions.
- Author(s)
  Yoshitaka Sekine, Yosuke Furuya, Haruo Kato, Yoshiyuki Miyazawa, Takahiro Syuto, Seiji Arai,　Takashi Nitta, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
- Organizer
  Asian Pacific Prostate Society 2014
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23390378
[Presentation] 去勢抵抗性前立腺癌発症の基礎的検討：脂質代謝に関して
- Author(s)
  関根芳岳、鈴木和浩
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23390378

1. SUZUKI Kazuhiro (80312891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
2. ITO Kazuto (00302472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. MATSUI Hiroshi (40450374)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. KOIKE Hidekazu (90420091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. 柴田康博 (90344936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Sekine Yoshitaka 関根 芳岳

SEKINE Yoshitaka 関根 芳岳

Research Projects

Research Products

Co-Researchers

神経内分泌細胞分化前立腺癌における脂質代謝を介した増殖メカニズムの基礎的検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combination therapy of PARP inhibitor, statin and platinum-containing drug for prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combination therapy with X-ray or heavy ion therapy and statin for prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lipid and steroid metabolism and prostate cancer using imaging mass-spectrometry

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of statins on de novo steroid synthesis pathways in androgen independent prostate cancer cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of lipid metabolism in prostate cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of statin on prostate cancer progression via miRNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Simvastatin in combination with meclofenamic acid inhibits the proliferation and migration of human prostate cancer PC-3 cells via an AKR1C3 mechanism.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simvastatin Up-Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen-Independent Human Prostate Cancer Cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of prostate cancer in a patient with primary hypogonadism : intratumoural steroidogenesis in prostate cancer tissues2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Diagnostic significance of [-2]pro-PSA and prostate dimension-adjusted PSA-related indices in men with total PSA in the 2.0-10.0 ng/mL range2013

Author(s)

Journal Title

Data Source

[Journal Article] Androgen receptor coactivator p120 subtype β is highly expressed in prostate cancer2013

Author(s)

Journal Title

Data Source

Sekine Yoshitaka 関根芳岳

SEKINE Yoshitaka 関根芳岳