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TSUKAHARA Tamotsu  塚原 完

Researcher Number 00529943
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6469-920X
Affiliation (based on the past Project Information) *help 2014 – 2024: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授
2015: 長崎大学, 医歯(薬)学総合研究科, 准教授
2013: 金沢医科大学, 医学部, 特定講師
2013: 金沢医科大学, 医学部, 講師
2010 – 2012: 信州大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Basic Section 48030:Pharmacology-related / General surgery / Digestive surgery
Except Principal Investigator
Orthopaedic surgery / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 56020:Orthopedics-related / Anesthesiology / Biomedical engineering/Biomaterial science and engineering / Urology
Keywords
Principal Investigator
リゾリン脂質 / 生理活性脂質 / 核内受容体 / 認知症 / 凝集体 / 神経変性疾患 / α-シヌクレイン / パーキンソン病 / 受容体 / 脳血管疾患 … More / ミクログリア細胞 / ミトコンドリア / アデニンヌクレオチド輸送体 / 細胞死 / 環状ホスファチジン酸 / ミクログリア / 炎症 / 糖尿病 / 動脈硬化症 / 血管内膜肥厚 / 内膜肥厚 / 動脈硬化 / ハイドロゲル / 大腸がん / 大腸癌 … More
Except Principal Investigator
脊髄損傷 / カーボンナノチューブ / 生体安全性 / 生体材料 / 生体反応 / カーボンナノ粒子 / アミロイドタンパク質 / 神経再生 / 脂肪酸 / グリア細胞 / ニューロン / リゾリン脂質 / Imaging MS解析 / 脳卒中後慢性疼痛 / LPA受容体 / Empathy / Centralized Pain / in vivoイメージング / 痛みメモリー / エピゲノム / 創薬スクリーニング / eRNA-CAGE法 / 有痛性糖尿病 / リゾフォスファチジン酸 / eRNA-CAGE解析 / PET解析 / 質量顕微鏡 / 創薬基盤研究 / 生合成酵素阻害剤 / 受容体拮抗薬 / 疼痛メモリー / 慢性疼痛 / リゾホスファチジン酸 / 画像解析 / 脳卒中後疼痛 / 創薬 / 免疫 / 脳画像解析 / 脳卒中後痛 / 糖尿病性神経障害性疼痛 / 線維筋痛症 / 神経障害性疼痛 / LPA / 脊椎損傷 / リン脂質 / 生理活性物質 / 骨芽細胞 / バイオマテリアル / 骨・軟骨代謝学 / エンドサイトーシス / ナノマテリアル / 生体物性 / 治療標的分子 / cDNAマイクロアレイ法 / レプチン / 肥満 / ホルモン抵抗性 / 前立腺癌 Less
  • Research Projects

    (11 results)
  • Research Products

    (72 results)
  • Co-Researchers

    (30 People)
  •  Elucidation of alpha-synuclein aggregation inhibition mechanism by lysophospholipids and development of drug discovery for neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      塚原 完
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Nagasaki University
  •  Elucidation of unique biological reactions to carbon nanoparticles and world's first clinical application and safety assessment of an innovative biomaterials

    • Principal Investigator
      齋藤 直人
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Shinshu University
  •  Role and mechanism of lysophospholipids in functional recovery of spinal cord-injured motor paralysis

    • Principal Investigator
      Haniu Hisao
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Shinshu University
  •  Developing novel therapeutic strategies for cerebrovascular disease by delayed neuronal death inhibitionPrincipal Investigator

    • Principal Investigator
      Tsukahara Tamotsu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Nagasaki University
  •  LPA signaling molecules and basic diagnostic and therapeutic studies on chronic pain

    • Principal Investigator
      UEDA HIROSHI
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Anesthesiology
    • Research Institution
      Production Development Science Research Institute
      Kyoto University
      Nagasaki University
  •  Development of the therapeutic drug for the spinal cord injury with the bioactive substance derived from porcine liver decomposition

    • Principal Investigator
      Haniu Hisao
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Shinshu University
  •  The effect of cPA on carotid intimate-media thickness progression in animal model with atherosclerosisPrincipal Investigator

    • Principal Investigator
      TSUKAHARA Tamotsu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Nagasaki University
      Kanazawa Medical University
  •  Identification of the specific receptors for the nanomaterials

    • Principal Investigator
      USUI Yuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Shinshu University
  •  Elucidation of the calcified promotion mechanism of osteoblasts by the carbon nanotubes

    • Principal Investigator
      HANIU Hisao
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Shinshu University
  •  Elucidation of the anticancer mechanism of the lysophospholid through the nuclear receptorPrincipal Investigator

    • Principal Investigator
      TSUKAHARA Tamotsu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Shinshu University
  •  アディポカインシグナル伝達に基づくホルモン抵抗性前立腺癌の新規治療標的分子の同定

    • Principal Investigator
      岩本 芳樹
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Shinshu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Book Patent

  • [Book] Medical Science Digest2022

    • Author(s)
      塚原 完・唐木 達哉・羽二生 久夫・上芝 洸貴・松田 佳和
    • Total Pages
      60
    • Publisher
      株式会社 ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-23K24773
  • [Book] Regulation of the Nuclear Hormone Receptor PPARγ by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors: Signaling and Biochemistry (edited by Jerold Chun) John Wiley book (ISBN: 978-0-470-56905-4)2013

    • Author(s)
      Ryoko Tsukahara, Tamotsu Tsukahara, Gabor Tigyi
    • Total Pages
      808
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Book] Regulation of the Nuclear Hormone Receptor PPARγ by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors: Signaling and Biochemistry2012

    • Author(s)
      Ryoko Tsukahara
    • Publisher
      John Wiley book
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Book] Regulation of the Nuclear Hormone Receptor PPAR_Y by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors2012

    • Author(s)
      Ryoko Tsukahara, Tamotsu Tsukahahara, Gabor Tigyi
    • Total Pages
      750
    • Publisher
      John Wiley Book
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Lysophospholipids transport across blood-brain barrier in an in vitro reconstruction model2023

    • Author(s)
      Tsukahara Tamotsu、Sasaki Masanori、Haniu Hisao、Matsuda Yoshikazu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 676 Pages: 91-96

    • DOI

      10.1016/j.bbrc.2023.07.044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22H00582, KAKENHI-PROJECT-23K24773
  • [Journal Article] リゾリン脂質経口摂取による神経変性疾患の新規創薬基盤開発.2022

    • Author(s)
      塚原完, 唐木達哉, 羽二生久夫, 上芝洸貴, 松田佳和.
    • Journal Title

      Medical Science Digest

      Volume: 48 Pages: 47-9

    • Data Source
      KAKENHI-PROJECT-20K09476
  • [Journal Article] Lysophospholipids-potent candidates for brain food, protects neuronal cells against α-Synuclein aggregation.2022

    • Author(s)
      Karaki T, Haniu H, Matsuda Y, Tsukahara T.
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 156 Pages: 113891-113891

    • DOI

      10.1016/j.biopha.2022.113891

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09476, KAKENHI-PROJECT-23K24773
  • [Journal Article] Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders2022

    • Author(s)
      Karaki Tatsuya、Haniu Hisao、Matsuda Yoshikazu、Tsukahara Tamotsu
    • Journal Title

      Biomedicines

      Volume: 10 Issue: 12 Pages: 3126-3126

    • DOI

      10.3390/biomedicines10123126

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09476, KAKENHI-PROJECT-23K24773
  • [Journal Article] The Combined Effects of Lysophospholipids against Lipopolysaccharide-induced Inflammation and Oxidative Stress in Microglial Cells2021

    • Author(s)
      Tamotsu Tsukahara, Hiroto Hara, Hisao Haniu, Yoshikazu Matsuda
    • Journal Title

      J. Oleo Sci.

      Volume: 70 Issue: 7 Pages: 947-954

    • DOI

      10.5650/jos.ess21069

    • NAID

      130008059932

    • ISSN
      1345-8957, 1347-3352
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Journal Article] Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons2021

    • Author(s)
      Kazutoshi Hisano, Hironori Yoshida, Shiori Kawase, Tetsuhiko Mimura, Hisao Haniu, Tamotsu Tsukahara, Taiga Kurihara, Yoshikazu Matsuda, Naoto Saito, Takeshi Uemura
    • Journal Title

      The Journal of Biochemistry

      Volume: 170 Issue: 3 Pages: 327-336

    • DOI

      10.1093/jb/mvab046

    • NAID

      40022722431

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07322, KAKENHI-PROJECT-19H03334, KAKENHI-PROJECT-20K09476
  • [Journal Article] Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades2021

    • Author(s)
      Hisano Kazutoshi、Kawase Shiori、Mimura Tetsuhiko、Yoshida Hironori、Yamada Hiroki、Haniu Hisao、Tsukahara Tamotsu、Kurihara Taiga、Matsuda Yoshikazu、Saito Naoto、Uemura Takeshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 534 Pages: 179-185

    • DOI

      10.1016/j.bbrc.2020.11.119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09476, KAKENHI-PROJECT-19K07322, KAKENHI-PROJECT-19H03334
  • [Journal Article] Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells2021

    • Author(s)
      Tsukahara Tamotsu、Sahara Yasuka、Ribeiro Nigel、Tsukahara Ryoko、Gotoh Mari、Sakamoto Satoshi、Handa Hiroshi、Murakami-Murofushi Kimiko
    • Journal Title

      Cellular Signalling

      Volume: 82 Pages: 109951-109951

    • DOI

      10.1016/j.cellsig.2021.109951

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07098, KAKENHI-PROJECT-19K07322
  • [Journal Article] Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells2021

    • Author(s)
      Tamotsu Tsukahara, Yasuka Sahara, Nigel Ribeiro, Ryoko Tsukahara, Mari Gotoh, Satoshi Sakamoto, Hiroshi Handa, Kimiko Murakami-Murofushi
    • Journal Title

      Cellular Signalling

      Volume: 82 Pages: 109951-10995

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Journal Article] Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain2021

    • Author(s)
      Tanaka Keigo、Dozono Naoki、Neyama Hiroyuki、Nagai Jun、Tsukahara Ryoko、Nagayasu Kazuki、Kaneko Shuji、Ueda Hiroshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 568 Pages: 167-173

    • DOI

      10.1016/j.bbrc.2021.06.058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01586, KAKENHI-PUBLICLY-20H04774, KAKENHI-PROJECT-20K07064
  • [Journal Article] Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro2020

    • Author(s)
      Tamotsu Tsukahara, Hisao Haniu, Takeshi Uemura, Yoshikazu Matsuda
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3748-3748

    • DOI

      10.1038/s41598-020-60781-1

    • NAID

      120006988275

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07322, KAKENHI-PROJECT-20K09476
  • [Journal Article] Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study2020

    • Author(s)
      Yoshikazu Matsuda, Hisao Haniu, Tamotsu Tsukahara, Takeshi Uemura, Toshio Inoue, Ken-Ichi Sako, Jun Kojima, Tatsuro Mori, Kazusaburou Sato
    • Journal Title

      Experimental Gerontology

      Volume: 141 Pages: 111064-111064

    • DOI

      10.1016/j.exger.2020.111064

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Journal Article] Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases2020

    • Author(s)
      Tamotsu Tsukahara, Hisao Haniu, Takeshi Uemura & Yoshikazu Matsuda
    • Journal Title

      biomedicines

      Volume: 8 Issue: 11 Pages: 446-446

    • DOI

      10.3390/biomedicines8110446

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07322, KAKENHI-PROJECT-20K09476
  • [Journal Article] 1-O-alkyl glycerophosphate-induced CD36 expression drives oxidative stress in microglial cells2019

    • Author(s)
      Tamotsu Tsukahara
    • Journal Title

      Cellular Signalling

      Volume: 65 Pages: 109459-109459

    • DOI

      10.1016/j.cellsig.2019.109459

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Journal Article] Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene2018

    • Author(s)
      Neyama H, Hamada Y, Tsukahara R, Narita M, Tsukamoto K, Ueda H
    • Journal Title

      Peptides

      Volume: 107 Pages: 10-16

    • DOI

      10.1016/j.peptides.2018.06.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08912, KAKENHI-PROJECT-17H01586
  • [Journal Article] LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model2018

    • Author(s)
      Tsukahara Ryoko、Yamamoto Shinji、Yoshikawa Keisuke、Gotoh Mari、Tsukahara Tamotsu、Neyama Hiroyuki、Ishii Satoshi、Akahoshi Noriyuki、Yanagida Keisuke、Sumida Hayakazu、Araki Masatake、Araki Kimi、Yamamura Ken-ichi、Murakami-Murofushi Kimiko、Ueda Hiroshi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 136 Issue: 2 Pages: 93-96

    • DOI

      10.1016/j.jphs.2018.01.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-17K08287, KAKENHI-PROJECT-17K19918, KAKENHI-PROJECT-17H01586, KAKENHI-PROJECT-16H05136, KAKENHI-PROJECT-26860144, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K21229
  • [Journal Article] Tyrosyl-tRNA synthetase: a potential kyotorphin synthetase in mammals.2018

    • Author(s)
      Tsukahara T, Yamagishi S, Neyama H, Ueda H
    • Journal Title

      Peptides

      Volume: 101 Pages: 60-68

    • DOI

      10.1016/j.peptides.2017.12.026

    • NAID

      130007901638

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01586
  • [Journal Article] Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain2018

    • Author(s)
      Ueda Hiroshi、Neyama Hiroyuki、Nagai Jun、Matsushita Yosuke、Tsukahara Tamotsu、Tsukahara Ryoko
    • Journal Title

      PAIN

      Volume: 159 Issue: 11 Pages: 2170-2178

    • DOI

      10.1097/j.pain.0000000000001316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01586
  • [Journal Article] Lysophospholipid-Related Diseases and PPARγ Signaling Pathway2017

    • Author(s)
      Tsukahara Tamotsu、Matsuda Yoshikazu、Haniu Hisao
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 12 Pages: 2730-2730

    • DOI

      10.3390/ijms18122730

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Journal Article] Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons2017

    • Author(s)
      Tsukahara Tamotsu、Yamagishi Shuhei、Matsuda Yoshikazu、Haniu Hisao
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 491 Issue: 1 Pages: 223-227

    • DOI

      10.1016/j.bbrc.2017.07.082

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Journal Article] Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels2016

    • Author(s)
      Tamotsu Tsukahara, Hisao Haniu, Yoshikazu Matsuda, and Kimiko Murakami-Murofushi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 473 Issue: 1 Pages: 107-113

    • DOI

      10.1016/j.bbrc.2016.03.060

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293274
  • [Journal Article] ラットの空間認知記憶に及ぼすコリン塩化物長期摂取の影響2016

    • Author(s)
      井上俊夫, 松田佳和, 佐藤卓美, 櫻田誓, 羽二生久夫, 塚原完, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.
    • Journal Title

      医学と薬学

      Volume: 73 Pages: 1009-1016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Journal Article] ブタ肝臓分解物のヒト認知機能改善効果2016

    • Author(s)
      松田佳和, 羽二生久夫, 塚原完, 井上俊夫, 佐古兼一, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.
    • Journal Title

      医学と薬学

      Volume: 73 Pages: 1057-1066

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Journal Article] The role of autophagy as a mechanism of toxicity induced by multi-walled carbon nanotubes in human lung cells.2015

    • Author(s)
      Tsukahara T, Matsuda Y, Haniu H.
    • Journal Title

      Int J Mol Sci.

      Volume: 16 Issue: 1 Pages: 40-48

    • DOI

      10.3390/ijms16010040

    • NAID

      120007110640

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
  • [Journal Article] Cyclic Phosphatidic Acid inhibits the Secretion of Vascular Endothelial Growth Factor from Diabetic Human Coronary Artery Endothelial Cells through Peroxisome Proliferator-activated Receptor Gamma2015

    • Author(s)
      Tamotsu Tsukahara, Ryoko Tsukahara, Hisao Haniu Yoshikazu Matsuda, and Kimiko Murakami-Murofushi
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: 412 Pages: 320-329

    • DOI

      10.1016/j.mce.2015.05.021

    • NAID

      120006986899

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293274
  • [Journal Article] Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells.2015

    • Author(s)
      Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Nomura H, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H.
    • Journal Title

      BioMed Res Int.

      Volume: 2015 Pages: 793186-793186

    • NAID

      120007110651

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25350524
  • [Journal Article] Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells2014

    • Author(s)
      Haniu H, Saito N, Matsuda Y, Tsukahara T, Usui Y, Maruyama K, Takanashi S, Aoki K, Kobayashi S, Nomura H, Tanaka M, Okamoto M, Kato H.
    • Journal Title

      Int J Nanomedicine.

      Volume: 9 Pages: 1979-90

    • NAID

      120007110603

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25350524
  • [Journal Article] The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells.2014

    • Author(s)
      Tsukahara T, Matsuda Y, Usui Y, Haniu H.
    • Journal Title

      Int J Mol Sci.

      Volume: 16 Pages: 40-48

    • NAID

      120007110640

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25350524
  • [Journal Article] Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate- Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells2014

    • Author(s)
      Tamotsu Tsukahara, Hisao Haniu, and Yoshikazu Matsuda
    • Journal Title

      International Journal of Medical Sciences

      Volume: 11 Issue: 9 Pages: 955-961

    • DOI

      10.7150/ijms.9316

    • NAID

      120007110639

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293274
  • [Journal Article] Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells.2014

    • Author(s)
      Ryoko Tsukahara, Hisao Haniu, Yoshikazu Matsuda, Tamotsu Tsukahara
    • Journal Title

      FEBS OPEN BIO

      Volume: 4 Issue: 1 Pages: 947-51

    • DOI

      10.1016/j.fob.2014.10.014

    • NAID

      120007110641

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293274
  • [Journal Article] PTB-Associated Splicing Factor (PSF) is a PPAR gamma-Binding Protein and Growth Regulator of Colon Cancer Cells2013

    • Author(s)
      Tamotsu Tsukahara, Hisao Haniu and Yoshikazu Matsuda
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 3 Pages: e58749-e58749

    • DOI

      10.1371/journal.pone.0058749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response2013

    • Author(s)
      Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, Aoki K, Takanashi S, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H
    • Journal Title

      Toxicol in Vitro

      Volume: 27 Issue: 6 Pages: 1679-1685

    • DOI

      10.1016/j.tiv.2013.04.012

    • NAID

      120007110519

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670, KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
  • [Journal Article] Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells.2013

    • Author(s)
      Tsukahara T, Matsuda Y, Usui Y, Haniu H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 440 Issue: 2 Pages: 348-53

    • DOI

      10.1016/j.bbrc.2013.09.089

    • NAID

      120007100190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
  • [Journal Article] PPARγ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid2013

    • Author(s)
      Tamotsu Tsukahara
    • Journal Title

      Journal of Lipids

      Pages: 1-6

    • URL

      http://dx.DOI:.org/10.1155/2013/246597

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Cyclic Phosphatidic Acid: An Endogenous Antagonist of PPARγ2013

    • Author(s)
      Tamotsu Tsukahara, Yoshikazu Matsuda, Hisao Haniu and Kimiko Murakami- Murofushi
    • Journal Title

      Journal of Endocrinology, Diabetes & Obesity

      Volume: 1 Pages: 1005-1005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293274
  • [Journal Article] The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists2012

    • Author(s)
      Tamotsu Tsukahara
    • Journal Title

      PPAR research

      Volume: 2012 Pages: 1-9

    • DOI

      10.1155/2012/362361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Peroxisome Proliferator-Activated Receptor gamma Overexpression Suppresses Proliferation of Human Colon Cancer Cells2012

    • Author(s)
      Tamotsu Tsukahara and Hisao Haniu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 424 Pages: 524-529

    • URL

      http://dx.DOI:.org/10.1016/j.bbrc.2012.06.149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] The Role of PPAR_Y in the Transcriptional Control by Agonists and Antagonists2012

    • Author(s)
      Tamotsu Tsukahara
    • Journal Title

      PPAR research

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Murofushi Release of cyclic phosphatidic acid from a gelatin-based hydrogel inhibits colon cancer cell growth and migration2012

    • Author(s)
      Tamotsu Tsukahara and Kimiko Murakami
    • Journal Title

      Scientific Reports

      Volume: 687 Issue: 1 Pages: 1-7

    • DOI

      10.1038/srep00687

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Lysophosphatidic Acid Stimulates MCP-1 Secretion from C2C12 Myoblast ISRN2012

    • Author(s)
      Tamotsu Tsukahara and Hisao Haniu
    • Journal Title

      Inflammation

      Volume: 2012 Pages: 1-6

    • DOI

      10.5402/2012/983420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Cyclic Phosphatidic Acid Influences the Expression and Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 cells2011

    • Author(s)
      Tamotsu Tsukahara, Shuwa Hanazawa, Kimiko Murofushi-Murakami
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 404 Pages: 109-114

    • NAID

      120007110486

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Phospholipase A_1 Activity of Lysophospholipase A-I Links Platelet Activation to LPA Production During Blood Coagulation2011

    • Author(s)
      Alyssa L.Bolen, Anjapravanda P.Naren, Sunitha, Tamotsu Tsukahara, Gabor Tigyi
    • Journal Title

      Journal of Lip id Research

      Volume: 52 Pages: 958-970

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPAR by cyclic nhosphatidic acid2010

    • Author(s)
      Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, et al.
    • Journal Title

      Molecular Cell

      Volume: 39 Pages: 421-432

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Cyclic Phosphatidic Acid Decreases Proliferation and Survival of Colon Cancer Cells through Inhibition of Peroxisome Proliferator-Activated Receptor γ2010

    • Author(s)
      Tamotsu Tsukahara, Shuwa Hanazawa, Tetsuyuki Kobayashi and Kimiko Murofusi-Murakami
    • Journal Title

      Prostaglandins and Other Lipid Mediators

      Volume: 93 Pages: 126-133

    • URL

      http://dx.DOI:.org/10.1016/j.prostaglandins.2010.09.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid2010

    • Author(s)
      Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Juming Yue, Yunhui Cheng, Huazhan Guo, Alyssa Bolen, Chhunxiang Zhang, Louis Balazs, Fabio Re, Guangwei Du, Michael A Frohman, Daniel L. Baker, Abby.L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi, Kimiko-Murofushi, and Gabor Tigyi
    • Journal Title

      Molecular Cell

      Volume: 39 Pages: 421-432

    • URL

      http://dx.DOI:.org/10.1016/j.molcel.2010.07.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Journal Article] Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells through inhibition of peroxisome proliferator-activated recentor gamma2010

    • Author(s)
      Tamotsu Tsukahara, Shuwa Ha nazawa, et al.
    • Journal Title

      Prostaglandins and Other Lipid Mediators

      Volume: 93 Pages: 126-133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Patent] 神経機能再生促進剤2019

    • Inventor(s)
      井上俊夫、植村健、塚原完、羽二生久夫、松田佳和、佐藤和三郎
    • Industrial Property Rights Holder
      佐藤和三郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Presentation] シード依存的なαシヌクレイン凝集で生じる細胞機能障害に対する生理活性リン脂質の薬理的効果2023

    • Author(s)
      古川 雅也, 田中 美空, 佐々木 政徳, 松田 佳和, 羽二生 久夫, 塚原 完
    • Organizer
      第97回日本薬理学会年会 (神戸)
    • Data Source
      KAKENHI-PROJECT-23K24773
  • [Presentation] Abundant oleoyl-lysophosphatidylethanolamine in brain exerts stimulation of neurite outgrowth and protection against glutamate toxicity in cultured cortical neurons2022

    • Author(s)
      Aoi William Oumi, Kazutoshi Hisano, Hironori Yoshida, Shiori Kawase, Tetsuhiko Mimura, Ryouya Nakada, Hisao Haniu, Tamotsu Tsukahara, Taiga Kurihara, Yoshikazu Matsuda, Naoto Saito, Takeshi Uemura
    • Organizer
      第45回日本神経科学大会 NEURO2022 (沖縄) 2022年6月30日
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Presentation] α-シヌクレインの凝集体形成を抑制する生理活性脂質の探索2022

    • Author(s)
      Tatsuya Karaki , Hisao Haniu , Yoshikazu Matsuda , Tamotsu Tsukahara
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-23K24773
  • [Presentation] アルツハイマー型認知症の予防及び治療におけるリゾリン脂質の可能性2022

    • Author(s)
      上芝 洸貴 , 上田 勝也 , 馬 闖 , 泉谷 惇 , 塚原 完 , 松田 佳和 , 齋藤 直人 , 羽二生 久夫
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-23K24773
  • [Presentation] Abundant oleoyl-lysophosphatidylethanolamine in brain exerts stimulation of neurite outgrowth and protection against glutamate toxicity in cultured cortical neurons2022

    • Author(s)
      Aoi William Oumi, Kazutoshi Hisano, Hironori Yoshida, Shiori Kawase, Tetsuhiko Mimura, Ryouya Nakada, Hisao Haniu, Tamotsu Tsukahara, Taiga Kurihara, Yoshikazu Matsuda, Naoto Saito, Takeshi Uemura
    • Organizer
      第45回日本神経科学大会 NEURO2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24773
  • [Presentation] アルツハイマー型認知症の治療及び予防におけるリゾリン脂質の可能性.2022

    • Author(s)
      上芝洸貴, 上田勝也, 馬闖, 泉谷惇, 塚原完, 松田佳和, 齋藤直人, 羽二生久夫.
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K09476
  • [Presentation] α-シヌクレインの凝集体形成を抑制する神経機能性リン脂質に関する研究2021

    • Author(s)
      唐木 達哉 , 塚原 完
    • Organizer
      第63回 日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Presentation] 長谷川式認知症スケールに対するブタ肝臓分解物の効果2020

    • Author(s)
      石田 季子 , 羽二生 久夫 , 塚原 完 , 植村 健 , 佐藤 和三郎 , 佐古 兼一 , 井上 俊夫 , 松田 佳和
    • Organizer
      日本薬学会 第140年会 (京都)
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Presentation] ミクログリア細胞における2ccPA結合タンパク質の同定と細胞死制御作用2020

    • Author(s)
      佐原 慈佳 , 塚原 完
    • Organizer
      第93回日本薬理学会年会 (横浜) 誌上開催
    • Data Source
      KAKENHI-PROJECT-19K07322
  • [Presentation] Tyrosyl-tRNA synthetase: a potential kyotorphin synthetase in mammals2018

    • Author(s)
      Hiroshi Ueda, Tamotsu Tsukahara
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01586
  • [Presentation] 脊髄損傷モデルラットにおけるブタ肝臓分解物の治癒効果の検討2018

    • Author(s)
      上田勝也, 鎌仲貴之, 滝沢崇, 黒田千佳, 石田悠, 塚本圭祐, 佐藤和三郎, 塚原完, 松田佳和, 齋藤直人, 羽二生久夫
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Presentation] 摘出リンパ管を用いた薬物評価システムの開発2017

    • Author(s)
      黒田千佳、安嶋久美子、羽二生久夫、塚原完、松田佳和、青木薫、加藤博之、齋藤直人
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎市,長崎ブリックホール
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K15660
  • [Presentation] リゾリン脂質を介した新生内膜形成と動脈硬化症2016

    • Author(s)
      塚原 完
    • Organizer
      第25回神経行動薬理若手研究者の集い シンポジウム:健康寿命の延伸を受けた新たなアプローチ
    • Place of Presentation
      埼玉県さいたま市 ソニックシティビル 公益財団法人埼玉県産業文化センター
    • Year and Date
      2016-03-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293274
  • [Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013

    • Author(s)
      Hisao Haniu, Naoto Saito, Yoshikazu Matsuda, Kayo Maruyama, Tamotsu Tsukahara, Yuki Usui, Kaoru Aoki, Seiji Takanashi, Shinsuke Kobayashi, Hiroki Nomura, Masanori Okamoto, Masayuki Shimizu, Hiroyuki Kato.
    • Organizer
      6th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      愛知県名古屋市
    • Data Source
      KAKENHI-PROJECT-25462365
  • [Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013

    • Author(s)
      Hisao Haniu, Naoto Saito, Yoshikazu Matsuda, Kayo Maruyama, Tamotsu Tsukahara, Yuki Usui, Kaoru Aoki, Seiji Takanashi, Shinsuke Kobayashi, Hiroki Nomura, Masanori Okamoto, Masayuki Shimizu, Hiroyuki Kato.
    • Organizer
      6th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      愛知県名古屋市
    • Data Source
      KAKENHI-PROJECT-25350524
  • [Presentation] Release of Cyclic Phosphatidic Acid from a Gelatin-Based Hydrogel Inhibits Colon Cancer Cell Growth and Migration2012

    • Author(s)
      Tamotsu Tsukahara
    • Organizer
      Annual Meeting of the Japanese Biochemical Society, Japanese Biochemical Society
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Presentation] Release of Cyclic Phosphatidic Acid from a Gelatin-Based Hydrogel Inhibits Colon Cancer Cell Growth and MigrationAnnual Meeting of the Japanese Biochemical Society2012

    • Author(s)
      Tamotsu Tsukahara and Kimiko Murakami-Murofushi
    • Organizer
      Japanese Biochemical Society
    • Place of Presentation
      Fukuoka, Kyushu, Japan
    • Year and Date
      2012-12-15
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Presentation] Cyclic phosphatidic acid inhibits colon cancer cell proliferation through suppression of peroxisome proliferator-activated receptor gamma2011

    • Author(s)
      Tamotsu Tsukahara and Kimiko Murakami-Murofushi
    • Organizer
      ASBMB Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Presentation] Cyclic phosphatidic acid inhibits colon cancer cell proliferation through suppression of peroxisome proliferator-activated receptor gamma2011

    • Author(s)
      Tamotsu Tsukahara, Kimiko Murakami-Murofushi
    • Organizer
      ASBMB Annual Meeting 2011
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Presentation] Phospholipase D2-dependent Inhibition of the Nuclear Hormone Receptor PPARga mma by Cyclic Phosnhatidic Acid2010

    • Author(s)
      Tamotsu Tsukahara
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-22591482
  • [Presentation] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid2010

    • Author(s)
      Tamotsu Tsukahara and Gabor Tigyi
    • Organizer
      The 83nd Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kobe, Hyogo, Japan
    • Data Source
      KAKENHI-PROJECT-22591482
  • 1.  HANIU Hisao (30252050)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 35 results
  • 2.  MATSUDA Yoshikazu (20377633)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 22 results
  • 3.  SAITO Naoto (80283258)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  USUI Yuki (00467169)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 5.  高橋 淳 (60345741)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  植村 健 (00372368)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  MUROFUSHI Kimiko (00103557)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  KOBAYASHI Shinsuke (40624705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  NOMURA Hiroki (40646543)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  UEDA HIROSHI (00145674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 11.  岩本 芳樹 (30569314)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  藤井 千文 (10361982)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  金子 周司 (60177516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  崔 翼龍 (60312229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  酒井 佑宜 (70588095)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  藤田 和歌子 (30382328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  松本 弦 (50415303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  片上 幸美 (60722296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  西村 直之 (10644940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  青木 薫 (30467170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  中村 真紀 (00568925)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  湯田坂 雅子 (70159226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TAKIZAWA Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  KAMANAKA Takayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 25.  KATSUYA Ueda
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 26.  GOTOH Mari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  斎藤 直人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 28.  塚元 和弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  荒木 正健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  荒木 喜美
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