YOKOYAMA Takashi 横山隆志

Researcher Number	00535833
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 特任助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 山梨大学, 大学院総合研究部, 特任助教 2018 – 2019: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 2017: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 2015: 公益財団法人がん研究会, 発がん研究部, 研究員 2014: 公益財団法人がん研究会, その他部局等, 研究員 … More 2012 – 2013: 公益財団法人がん研究会, がん研究所発がん研究部, 研究員 2011 – 2013: 公益財団法人がん研究会, がん研究所発がん研究部, 研究員 2011: 公益財団法人がん研究会, がん研究所・発がん研究部, 研究員 2009 – 2010: Japanese Foundation For Cancer Research, 癌研究所発がん研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Experimental pathology / Pathological medical chemistry Except Principal Investigator Cell biology / Carcinogenesis
Keywords	Principal Investigator C/EBPα / MAPキナーゼ経路 / 白血病 / Trib1 / Smad3 / TGF-β / ノックアウトマウス / STING / 転移 / SMAD3 … More / がん幹細胞 / 転移・浸潤 / EMT / がん幹細胞性 / TRIB1 / 細胞老化 / CSN5 / ROS / がん代謝 / がん / レトロウイルス挿入変異 / レトロウィルス挿入変異 / 転写因子 / ChIPシークエンス / Bcl11a / Hoxa9 / IL6r / 顆粒球分化 / C/EBPa / 造血 / Trib2 / EBPα / C / DS-AMKL / MAPK … More Except Principal Investigator 発がん機構 / エネルギー代謝 / 発がん / 細胞増殖分化 / ChIP-Seq / Bcl11a / Trib1 / Smad7 / CXCR4 / FLT3 / ノックアウトマウス / 骨髄ニッチ / Sytl1 / Meis1 / Hoxa9 / 急性骨髄性白血病 / シグナリング / 転写制御 / 遺伝子経路 / 実験動物モデル / 骨髄性白血病 Less

TGF-β/Smad3/STINGを介した抗腫瘍免疫回避機序の解明Principal Investigator
- Principal Investigator
  
  横山隆志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Yamanashi
TRIB1 promotes metastasis through transcriptional activation of EMT-related genesPrincipal Investigator
- Principal Investigator
  
  Yokoyama Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Yamanashi
Inhibition of novel cancer specific antioxidant regulation promotes anticancer functionPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Yamanashi
  Nara Institute of Science and Technology
Reprogramming of metabolic networks in COP1-mediated oncogenesis
- Principal Investigator
  
  Kato Noriko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Nara Institute of Science and Technology
Trib1 is an important adaptor that connects the MAP kinase pathway with C/EBPa in leukemogenesisPrincipal Investigator
- Principal Investigator
  
  Yokoyama Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Molecular basis of myeloid leukemogenesis
- Principal Investigator
  
  NAKAMURA Takuro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Carcinogenesis
- Research Institution
  Japanese Foundation for Cancer Research
Functional analysis of Trib1/2 double knockout mice on hematopoiesisPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Japanese Foundation For Cancer Research
Leukemogenic activity of Trib1Principal Investigator
- Principal Investigator
  
  YOKOYAMA Takashi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Japanese Foundation For Cancer Research

All 2022 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression2019
- Author(s)
  Nakamae Ikuko、Morimoto Tsumoru、Shima Hiroki、Shionyu Masafumi、Fujiki Hisayo、Yoneda-Kato Noriko、Yokoyama Takashi、Kanaya Shigehiko、Kakiuchi Kiyomi、Shirai Tsuyoshi、Meiyanto Edy、Kato Jun-ya
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 22 Pages: 4067-4067
- DOI
  10.3390/molecules24224067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12211, KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-17K07387
[Journal Article] Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence2019
- Author(s)
  Lestari Beni、Nakamae Ikuko、Yoneda-Kato Noriko、Morimoto Tsumoru、Kanaya Shigehiko、Yokoyama Takashi、Shionyu Masafumi、Shirai Tsuyoshi、Meiyanto Edy、Kato Jun-ya
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 14867-14867
- DOI
  10.1038/s41598-019-51244-3
- NAID
  120006732446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-17K07387
[Journal Article] Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.2018
- Author(s)
  Larasati YA, Yoneda-Kato N, Nakamae I, Yokoyama T, Meiyanto E, Kato JY.
- Journal Title
  
  Sci. Rep.
  
  Volume: ８ Issue: 1 Pages: 2039-2039
- DOI
  10.1038/s41598-018-20179-6
- NAID
  120006732447
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07387
[Journal Article] Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPalpha to prevent Trib1-driven acute myeloid leukemia.2017
- Author(s)
  Nakamae I, Kato JY, Yokoyama T, Ito H, Yoneda-Kato N
- Journal Title
  
  Blood Adv.
  
  Volume: 1 Issue: 20 Pages: 1682-1693
- DOI
  10.1182/bloodadvances.2017007054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07387, KAKENHI-PROJECT-17J07454
[Journal Article] MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.2016
- Author(s)
  Yokoyama T, Nakatake M, Kuwata T, Couiznet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T.
- Journal Title
  
  J Clin Invest.
  
  Volume: 印刷中 Issue: 5 Pages: 1664-1678
- DOI
  10.1172/jci81516
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-26250029, KAKENHI-PROJECT-25430121, KAKENHI-PROJECT-26640085, KAKENHI-PROJECT-26660259, KAKENHI-PROJECT-25292194, KAKENHI-PUBLICLY-15H01163, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05047
[Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia2012
- Author(s)
  Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park M, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T
- Journal Title
  
  Blood
  
  Volume: 199 Pages: 2608-2611
- Data Source
  KAKENHI-PROJECT-23240125
[Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia2012
- Author(s)
  Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park MJ, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T.
- Journal Title
  
  Blood
  
  Volume: 119 Issue: 11 Pages: 2608-2611
- DOI
  10.1182/blood-2010-12-324806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390316, KAKENHI-PROJECT-22591171, KAKENHI-PROJECT-22659196, KAKENHI-PROJECT-23390266, KAKENHI-PROJECT-23591560, KAKENHI-PROJECT-23790451, KAKENHI-PROJECT-24390268, KAKENHI-PUBLICLY-23118501
[Journal Article] Tribbles in disease : Signaling pathways important for cellular function and neoplastic transformation.2011
- Author(s)
  Takashi Yokoyama, Takuro Nakamura
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 1115-1122
- NAID
  10029294105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790333
[Journal Article] Tribbles in disease : Signaling pathways important for cellular function and neoplastic transformation.2011
- Author(s)
  Takashi Yokoyama, Takuro Nakamura.
- Journal Title
  
  Cancer Sci. 102
  
  Pages: 1115-1112
- NAID
  10029294105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790333
[Journal Article] Tribbles in disease : signaling pathways important for cellular function and neoplastic transformation2011
- Author(s)
  Yokoyama T, Nakamura T
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 1115-1122
- NAID
  10029294105
- Data Source
  KAKENHI-PROJECT-23240125
[Journal Article] Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis.2010
- Author(s)
  Takashi Yokoyama, Yohei Kanno, Yukari Yamazaki, Tomoko Takahara, Satoshi Miyata, Takuro Nakamura.
- Journal Title
  
  Blood 116
  
  Pages: 2768-2775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790333
[Journal Article] Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis.2010
- Author(s)
  Takashi Yokoyama, et al.
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 2768-2775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] TRIB1 regulates TGF-β-induced cell motility through degradation of C/EBPα2022
- Author(s)
  横山隆志，齋藤正夫，宮澤恵二
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07095
[Presentation] A novel curcumin analog inhibits tumorigenesis through prometaphase arrest and antioxidative interference2019
- Author(s)
  Jun-ya Kato, Ikuko Nakamae, Takashi Yokoyama and Noriko Kato, Edy Meiyanto
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07387
[Presentation] Tribbles-COP1 ligase complex in acute myeloid leukemia2018
- Author(s)
  Yoneda-Kato N, Ito H, Nakamae I, Yokoyama T, Kato JY.
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07387
[Presentation] 急性骨髄性白血病の発症過程におけるCOP1-Trib1複合体リガーゼを介したACC1蛋白質分解に伴う代謝機能異常に関する解析2018
- Author(s)
  伊藤秀矩、中前伊公子、横山隆志、加藤順也、加藤規子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07387
[Presentation] Suppression of tumor cell growth by targeting ROS metabolic enzymes.2018
- Author(s)
  Nakamae I, Yoneda-Kato N, Yokoyama T, Meiyanto E, Kato JY.
- Organizer
  Cold Spring Harbor Laboratory Meeting, New York, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07387
[Presentation] COP1-Trib1 targets ACC1 for degradation and protects leukemic cells from metabolic stress in acute myeloid leukemia.2018
- Author(s)
  Ito H, Nakamae I, Yokoyama T, Kato JY, Yoneda-Kato N.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07387
[Presentation] Modulation of gene expression by Trib1, an AML disease gene and a suppressor of C/EBPa2015
- Author(s)
  Takashi Yokoyama and Takuro Nakamura
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] Meis1標的遺伝子Sytl1はCXCL12/CXCR4シグナルを介してAMLの骨髄微小環境への定着を促進する2015
- Author(s)
  横山隆志，中武真由香，高原智子，山崎ゆかり，中村卓郎
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] The functional role of Trib1 in normal and neoplastic hematopoiesis2015
- Author(s)
  Takashi Yokoyama and Takuro Nakamura
- Organizer
  Tribbles Pseudokinases on the Crossroads of Metabolism, Cancer, Immunity and Development
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] Meis1標的遺伝子Sytl1はAMLの骨髄微小環境への定着を促進する2014
- Author(s)
  横山隆志，中武真由香，菅野陽平，高原智子，山崎淑子，山崎ゆかり，中村卓郎
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  ANAクラウンプラザホテル広島（広島）
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] Sytl1 promotes engraftment of Hoxa9/Meis1-induced AML in bone marrow niche b y modulating Flt3 and CXCR42014
- Author(s)
  横山隆志，中武真由香，中村卓郎
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] Trib1 AML を利用したBcl11a による白血病関連遺伝子制御の解析2013
- Author(s)
  横山隆志,山崎ゆかり,菅野陽平,高原智子,中村卓郎
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23240125
[Presentation] Sytl1 is a novel Meis1 target and a cooperative partner of Hoxa9 in AML development2012
- Author(s)
  Takashi Yokoyama, Mayuka Nakatake, Yohei Kanno, Tomoko Takahara, Yukari Yamazaki, Shuichi Tsutsumi, Hiroyuki Aburatani and Takuro Nakamura
- Organizer
  9th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia
- Place of Presentation
  アメリカ合衆国オハイオ州シンシナティ
- Year and Date
  2012-05-07
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Sytl1はAML発症におけるMeis1の新規標的遺伝子でありHoxa9に協調作用を示す2012
- Author(s)
  横山隆志,中武真由香,菅野陽平,高原智子,山崎ゆかり,堤修一,油谷浩幸,中村卓郎
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] 白血病原因遺伝子Trib1/2の発現と造血における役割2012
- Author(s)
  横山隆志,山崎ゆかり,菅野陽平,高原智子,西中村隆一,中村卓郎
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  新宿
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] TRIB1 gain-of-function mutation in Down syndrome-related leukemia.2011
- Author(s)
  Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-ja Park, Etsuro Ito, Yasuhide Hayashi and Takuro Nakamura.
- Organizer
  第70回　日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Trib1による白血病発症機構.平成23年度文科省科研費補助金2011
- Author(s)
  横山隆志,菅野陽平,山崎ゆかり,高原智子,宮田敏, 林泰秀,伊藤悦朗, 中村卓郎
- Organizer
  新学術領域「がん研究分野の特性等を踏まえた支援活動」がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] TRIB1 gain-of-function mutation in Down syndrome-related leukemia2011
- Author(s)
  Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-ja Park, Etsuro Ito, Yasuhide Hayashi and Takuro Nakamura
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Trib1によるMEK1/ERK経路とC/EBPα制御を介した白血病発症機構の解明2011
- Author(s)
  横山隆志,菅野陽平,山崎ゆかり,高原智子,宮田敏, 林泰秀,伊藤悦朗, 中村卓郎
- Organizer
  第7回血液学若手研究者勉強会(麒麟塾)
- Place of Presentation
  東京
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] TRIB1 gain-of-funcion mutation in Down syndrome-related leukemia2011
- Author(s)
  横山隆志
- Organizer
  日米血液腫瘍セミナー
- Place of Presentation
  葉山
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] ダウン症候群関連急性巨核球性白血病におけるTRIB1変異の同定2011
- Author(s)
  横山隆志,中村卓郎
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-29
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] TRIB1 gain-of-function mutation in Down syndrome-related leukemia.2011
- Author(s)
  Takashi Yokoyama, Yohei Kannno, Tomoko Takahara, Yukari Yamazaki, Etsuro Ito, Yasuhide Hayashi, Takuro Nakamura.
- Organizer
  日米血液腫瘍セミナー
- Place of Presentation
  葉山
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] Trib1によるMEK1/ERK経路とC/EBPα制御を介した白血病発症機構の解明2011
- Author(s)
  横山　隆志，菅野　陽平，山崎　ゆかり，高原　智子，宮田　敏，林　泰秀，伊藤　悦朗，中村　卓郎
- Organizer
  第7回血液学若手研究者勉強会（麒麟塾）
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Trib1による白血病発症機構2011
- Author(s)
  横山　隆志，菅野　陽平，山崎　ゆかり，高原　智子，宮田　敏，林　泰秀，伊藤　悦朗，中村　卓郎
- Organizer
  平成23年度文科省科研費補助金　新学術領域「がん研究分野の特性等を踏まえた支援活動」がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Trib1 is an important adapter that connects the MAP kinase pathway with C/EBPa in leukemogenesis2010
- Author(s)
  横山隆志
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] マウス白血病モデルを用いたTrib1による白血病発症機構の解析2010
- Author(s)
  横山隆志
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] マウス白血病モデルを用いたTrib1による白血病発症機構の解析2010
- Author(s)
  横山隆志、中村卓郎
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] Trib1 is an important adaptor that connects the MAP kinase pathway with C/EBP α in leukemogenesis.2010
- Author(s)
  Takashi Yokoyama, Takuro Nakamura.
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] MEK1 dependent leukemogenic activity of Trib12010
- Author(s)
  横山隆志
- Organizer
  8th Joint Conference of AACA and JCA
- Place of Presentation
  Hilton Waikoloa Village Waikoloa, Hawaii, USA
- Year and Date
  2010-02-07
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] MEK1 dependent leukemogenic activity of Trib1.2010
- Author(s)
  Takashi Yokoyama, Takuro Nakamura.
- Organizer
  8th Joint Conference of AACR and JCA
- Place of Presentation
  Hawaii
- Year and Date
  2010-02-07
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] AML原因遺伝子Trib1の機能におけるMEK1-ERK経路の役割2009
- Author(s)
  横山隆志
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] MEK1 dependent leukemogenic activity of Trib12009
- Author(s)
  横山隆志
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] The Ras-ERK pathway dependent leukemogenic activity of Trib12009
- Author(s)
  横山隆志
- Organizer
  文部科学省がん特定領域若手研究者ワークショップ
- Place of Presentation
  アートランドホテル蓼科
- Year and Date
  2009-09-02
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] MEK1 dependent leukemogenic activity of Trib1.2009
- Author(s)
  Takashi Yokoyama, Takuro Nakamura.
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] AML原因遺伝子Trib1の機能におけるMEK1.ERK経路の役割2009
- Author(s)
  横山隆志, 中村卓郎
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-21790333
[Presentation] Trib1 AMLを利用したBcl11aによる白血病関連遺伝子制御の解析
- Author(s)
  横山　隆志，山崎　ゆかり，菅野　陽平，高原　智子，中村　卓郎
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  さっぽろ芸文館（札幌）
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] 白血病原因遺伝子Trib1/2の発現と造血における役割
- Author(s)
  横山　隆志，山崎　ゆかり，管野陽平，高原智子，西中村隆一，中村　卓郎
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  新宿
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Sytl1はAML発症におけるMeis1の新規標的遺伝子でありHoxa9に協調作用を示す
- Author(s)
  横山　隆志，中武　真由香，管野陽平，高原智子，山崎　ゆかり，堤　修一，油谷　浩幸，中村　卓郎
- Organizer
  第71回　日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790451
[Presentation] Sytl1/Slp1 functions in the engraftment of AML into the bone marrow
- Author(s)
  Takashi Yokoyama, Mayuka Nakatake, Ayumi Nakamura Hidetoshi Tahara, Naoya Hatano, Takuro Nakamura
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25430121
[Presentation] Meis1標的遺伝子Sytl1の白血病発症における役割
- Author(s)
  横山隆志、中武真由香、倉田盛人、中村卓郎
- Organizer
  第１７回造血器腫瘍研究会兼がん研究開発費「がん幹細胞に対する新規分子標的治療薬の開発を目指した基盤研究」班会議
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-23790451

1. 加藤順也 (00273839)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. NAKAMURA Takuro (00180373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. GOITSUKA Ryo (50301552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITO Etsuro (20168339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. HAYASHI Yasuhide (30238133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Kato Noriko (10252785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. 中武真由香 (40432041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIONYU Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. PARK Myoung-Ja

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 堤修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 白井剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOKOYAMA Takashi 横山 隆志

Research Projects

Research Products

Co-Researchers

TGF-β/Smad3/STINGを介した抗腫瘍免疫回避機序の解明Principal Investigator

Principal Investigator

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Review Section

Research Institution

TRIB1 promotes metastasis through transcriptional activation of EMT-related genesPrincipal Investigator

Principal Investigator

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Review Section

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Inhibition of novel cancer specific antioxidant regulation promotes anticancer functionPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Reprogramming of metabolic networks in COP1-mediated oncogenesis

Principal Investigator

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Trib1 is an important adaptor that connects the MAP kinase pathway with C/EBPa in leukemogenesisPrincipal Investigator

Principal Investigator

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Research Institution

Molecular basis of myeloid leukemogenesis

Principal Investigator

Project Period (FY)

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Functional analysis of Trib1/2 double knockout mice on hematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Leukemogenic activity of Trib1Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPalpha to prevent Trib1-driven acute myeloid leukemia.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia2012

YOKOYAMA Takashi 横山隆志