Okubo Naoto 大久保直登

… Alternative Names

OKUBO Naoto 大久保直登

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Researcher Number	00553207
Other IDs
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 北海道大学, 薬学研究院, 講師 2021: 北海道大学, 薬学研究院, 講師 2019 – 2021: 北海道大学, 薬学研究院, 助教 2016 – 2018: 北海道大学, 薬学研究院, 特任助教 2015: 北海道大学, 薬学研究科(研究院), 博士研究員 … More 2014: 北海道大学, 薬学研究科(研究院), 研究員 2013: 北海道大学, 薬学研究科(研究院), 博士研究員 2012: 北海道大学, 薬学研究科(研究院), 研究員 2011: 岩手医科大学, 歯学部, ポスト・ドクター 2009 – 2011: Iwate Medical University, 歯学部, ポストドクター 2010: Iwate Medical University, 歯学部, その他 Less
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Dental engineering/Regenerative dentistry / Surgical dentistry / Functional basic dentistry Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 三次元培養 / 再生医療 / 歯根膜幹細胞 / 血管新生 / 歯根膜 / 間葉系幹細胞 / 徐放性素材 / サイトカイン / DDMスキャホールド / 軟組織マネージメント（抗瘢痕化） … More / 顎骨再生治療 / 象牙質移植法 / 軟組織適応可能 / 大型骨欠損対応型医療 / 骨再生治療 / ハイブリッド移植材 / 骨再生医療 / 骨補填材 / コラーゲン製材 / ＤＤＳ基材 / 象牙質移植材 / 靭帯・腱 / 組織再生 / 腱再生 / 靭帯再生 / 組織幹細胞 / 造血幹細胞 / 再生・幹細胞・血管新生 / 再生歯学 … More Except Principal Investigator 間葉系幹細胞 Less

Therapeutic effect of gene-modified MSC-derived exosomes in liver fibrosis
- Principal Investigator
  
  大西俊介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
Development of Jawbone Regeneration Therapy Incorporating Soft Tissue Management Utilizing High-Performance Scaffolds.Principal Investigator
- Principal Investigator
  
  大久保直登
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University
The establishment of novel bone regenerative therapies utilizing the Periodontal ligament stem cells / demineralized Dentin matrix hybrid grafting materialsPrincipal Investigator
- Principal Investigator
  
  Okubo Naoto
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University
Development of the tendon/ligament regenerative therapy utilizing human multipotent periodontal ligament stem cellsPrincipal Investigator
- Principal Investigator
  
  OKUBO Naoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
Establishment of neovascularization-inducing technology accompanied with hematopoiesis by utilizing Periodontal ligament derived stem cellsPrincipal Investigator
- Principal Investigator
  
  OKUBO Naoto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Hokkaido University
Identification of the key genes promoting angiogenesis and the signaling pathways regulating angiogenesis of the periodontal ligament derived stem cellsPrincipal Investigator
- Principal Investigator
  
  OKUBO Naoto
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Iwate Medical University
歯根膜由来幹細胞による血管構造形成メカニズムの解明Principal Investigator
- Principal Investigator
  
  大久保直登
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University

[Book] Biomaterial-supported Tissue Reconstruction or Regeneration2019
- Author(s)
  Masaru Murata, Naoto Okubo, Mamata Shakya, Md Arafat Kabir, Kenji Yokozeki, Bowen Zhu, Masahiro Ishikawa, Ryuji Kitamura and Toshiyuki Akazawa
- Total Pages
  150
- Publisher
  IntechOpen
- ISBN
  9781838803780
- Data Source
  KAKENHI-PROJECT-18H02997
[Book] Tooth Materials Science and Clinical Applications (one chapter 担当)2015
- Author(s)
  Masaru Murata, In-Woong Um, (Naoto Okubo, Akira Ishisaki)
- Publisher
  Quintessence Publisher
- Data Source
  KAKENHI-PROJECT-24792149
[Book] Advances in Oral Tissue Engineering2014
- Author(s)
  Masaru Murata, In-Woong Um, (Naoto Okubo, Akira Ishisaki)
- Total Pages
  72
- Publisher
  Quintessence Publishing
- Data Source
  KAKENHI-PROJECT-24792149
[Journal Article] Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice2021
- Author(s)
  Ohkawara Tatsuya、Okubo Naoto、Maehara Osamu、Nishihira Jun、Takeda Hiroshi
- Journal Title
  
  Toxicology Letters
  
  Volume: 339 Pages: 51-59
- DOI
  10.1016/j.toxlet.2020.12.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05500, KAKENHI-PROJECT-18H02997
[Journal Article] IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals.2018
- Author(s)
  Ohta M., Chosa N., Kyakumoto S., Yokota S., Okubo N., Nemoto A., Kamo M., Joh S., Satoh K., Ishisaki A.
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11234
[Journal Article] IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals2018
- Author(s)
  Ohta M., Chosa N., Kyakumoto S., Yokota S., Okubo N., Nemoto A., Kamo M., Joh S., Satoh K., Ishisaki A.
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 43 Pages: 1484-1494
- DOI
  10.3892/ijmm.2018.3714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11654, KAKENHI-PROJECT-17K11851, KAKENHI-PROJECT-16H05534, KAKENHI-PROJECT-26293426, KAKENHI-PROJECT-18H02997
[Journal Article] In vitroにおける人参養栄湯のミトコンドリア量に対する作用.2018
- Author(s)
  武田宏司, 大久保直登, 藤井崚介, 服部智久, 山田ちひろ
- Journal Title
  
  薬理と治療
  
  Volume: 46 Pages: 1347-1352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02997
[Journal Article] MICROCRACKS DESIGN AND BONE INDUCTION OF SKULL BONE MODIFIED BY ULTRASONIC TREATMENT USING ACIDIC ELECTROLYZED WATER2017
- Author(s)
  Shakya M., Murata M., Okubo N., Nagayasu H., Akazawa T.
- Journal Title
  
  Phosphorus Research Bulletin
  
  Volume: 33 Issue: 0 Pages: 1-6
- DOI
  10.3363/prb.33.1
- NAID
  130005628661
- ISSN
  0918-4783, 1882-2363
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11234
[Journal Article] Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture2017
- Author(s)
  Takizawa N, Okubo N, Kamo M, Chosa N, Mikami T, Suzuki K, Yokota S, Ibi M, Ohtsuka M, Taira M, Sasaki D, Yaegashi T, Ishisaki A, Kyakumoto S
- Journal Title
  
  Experimental Cell Res.
  
  Volume: 358 Issue: 2 Pages: 411-420
- DOI
  10.1016/j.yexcr.2017.07.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11630, KAKENHI-PROJECT-16K11654, KAKENHI-PROJECT-17K11851, KAKENHI-PROJECT-17K11917, KAKENHI-PROJECT-16H04685, KAKENHI-PROJECT-15K11234
[Journal Article] PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability.2016
- Author(s)
  Nakagawa K, Kohara T, Uehata Y, Miyakawa Y, Sato-Ueshima M, Okubo N, Asaka M, Takeda H, Kobayashi M
- Journal Title
  
  Biochemical and Bioohysical Research Communications
  
  Volume: 469 Issue: 3 Pages: 470-476
- DOI
  10.1016/j.bbrc.2015.12.047
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K11234
[Journal Article] Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats.2015
- Author(s)
  Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada K, Suda G, Natsuizaka M, Takeda H, Sakamoto N
- Journal Title
  
  Cell Transplantation
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24792149
[Journal Article] Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice.2015
- Author(s)
  Yamada C, Sadakane C, Nahata C, Saegusa Y, Nakagawa K, Okubo N, Ohnishi S, Hattori T, Takeda H
- Journal Title
  
  Psychoneuroendocrinology
  
  Volume: 55 Pages: 81-93
- DOI
  10.1016/j.psyneuen.2015.02.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24792149, KAKENHI-PROJECT-25460922
[Journal Article] Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.2014
- Author(s)
  Aomatsu, E., Takahashi, N., Sawada, S., Okubo, N., Hasegawa, T., Taira, M., Miura, H., Ishisaki, A., and Chosa, N.
- Journal Title
  
  Sci. Rep.
  
  Volume: 4 Issue: 1 Pages: 3652-3652
- DOI
  10.1038/srep03652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149, KAKENHI-PROJECT-25463053, KAKENHI-PROJECT-25463182, KAKENHI-PROJECT-25463224, KAKENHI-PROJECT-25893221, KAKENHI-PROJECT-26893249
[Journal Article] PDGF-induced PI3K-mediated signal enhances TGF-βinduced osteogenic differentiation of human mesenchymal stem cells in the TGF-β-activated MEK-dependent manner2014
- Author(s)
  Jun Yokota, Naoyuki Chosa, Shunsuke Sawada, Naoto Okubo, Noriko Takahashi, Tomokazu Hasegawa, Hisatomo Kondo, Akira Ishisaki
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 33 Issue: 3 Pages: 534-542
- DOI
  10.3892/ijmm.2013.1606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592864, KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149, KAKENHI-PROJECT-25463053, KAKENHI-PROJECT-25463224, KAKENHI-PROJECT-25893221
[Journal Article] Pathophysiologic Basis of Anorexia: Focus on the Interaction between Ghrelin Dynamics and the Serotonergic System2013
- Author(s)
  Takeda H, Nakagawa K, Okubo N, Nishimura M, Muto S, Ohnishi S, Sakamoto N, Hosono H, Asaka M.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36(9) Pages: 1401-1405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792149
[Journal Article] Transforming growth factor-β1 induces epithelialmesenchymal transition and integrin α3β1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug2013
- Author(s)
  Saito D, Kyakumoto S, Chosa N, Ibi M, Takahashi,N, Okubo N, Sawada S, Ishisaki A, & Kamo M
- Journal Title
  
  J. Biochem
  
  Volume: 153 Issue: 3 Pages: 303-315
- DOI
  10.1093/jb/mvs144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592076, KAKENHI-PROJECT-22791936, KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149
[Journal Article] 六君子湯による摂食不振・悪液質の改善2013
- Author(s)
  武田　宏司, 中川浩治, 西村三恵, 大久保　直登, 細野秀崇, 浅香正博, 武藤修一, 大西俊介, 坂本直哉
- Journal Title
  
  Jounal of Gastrointestinal Reserch　　2013;Vol21 no.1
  
  Volume: Vol21 no.1 Pages: 48-58
- Data Source
  KAKENHI-PROJECT-24792149
[Journal Article] 六君子湯による摂食不振・悪液質の改善2013
- Author(s)
  武田　宏司, 中川浩治, 西村三恵, 大久保　直登, 細野秀崇, 浅香正博, 武藤修一, 大西俊介, 坂本直哉
- Journal Title
  
  Jounal of Gastrointestinal Reserch
  
  Volume: 21(1) Pages: 48-58
- Data Source
  KAKENHI-PROJECT-24792149
[Journal Article] EGF positively regulates the proliferation and migration, and negatively regulates the myofibroblast differentiation of periodontal ligament-derived endothelial progenitor cells through MEK/ERK- and JNK-dependent signals.2013
- Author(s)
  Kimura, H., Okubo, N., Chosa, N., Kyakumoto, S., Kamo, M., Miura, H. and Ishisaki, A
- Journal Title
  
  Cell. Physiol. Biochem.
  
  Volume: 32 Issue: 4 Pages: 899-914
- DOI
  10.1159/000354493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149, KAKENHI-PROJECT-25463053
[Journal Article] Fibroblast growth factor-1-induced ERK1/2 signaling reciprocally regulates proliferation and smooth muscle cell differentiation of ligament-derived endothelial progenitor cell-like cells2012
- Author(s)
  Takahahi M, Okubo N, Chosa N, Takahashi N, Miho I, Kamo M, Mizuki H, Ishisaki A, & Kyakumoto S
- Journal Title
  
  Int. J. Mol.Med.
  
  Volume: 29 Pages: 357-364
- DOI
  10.3892/ijmm.2011.847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592076, KAKENHI-PROJECT-22791935, KAKENHI-PROJECT-22791936, KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149
[Journal Article] TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligamentderived endothelial progenitor cells through Smad- and p38 MAPK dependentsignals2012
- Author(s)
  Yoshida M, Okubo N, Chosa N, Hasegawa T, Ibi M, Kamo M, Kyakumoto S, & Ishisaki A
- Journal Title
  
  Int. J. Biol. Sci.
  
  Volume: 8 Issue: 7 Pages: 1062-1074
- DOI
  10.7150/ijbs.4488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592076, KAKENHI-PROJECT-22592296, KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149
[Journal Article] High-cell density-induced VCAM1 expression inhibits the migratory ability of mesenchymal stem cells2011
- Author(s)
  Nishihira S, Okubo N, et al.
- Journal Title
  
  Cell Biology International
  
  Volume: 35巻 Issue: 5 Pages: 475-481
- DOI
  10.1042/cbi20100372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791935, KAKENHI-PROJECT-22791936, KAKENHI-PROJECT-23592896
[Journal Article] Dental pulp cells derived from permanent teeth express higher levels of R-cadher in than do deciduous teeth : Implications of the correlation between R-cadherin expression and restriction of multipotency in mesenchymal stem cells2011
- Author(s)
  Takahashi N
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 57 Issue: 1 Pages: 44-51
- DOI
  10.1016/j.archoralbio.2011.07.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592076, KAKENHI-PROJECT-22592296, KAKENHI-PROJECT-22791935, KAKENHI-PROJECT-22791936, KAKENHI-PROJECT-23592896, KAKENHI-PROJECT-24792149
[Journal Article] Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K activation-dependent manner2010
- Author(s)
  Okubo N., Ishisaki A., Iizuka T., Tamura M., Kitagawa Y
- Journal Title
  
  J. Vasc. Res
  
  Volume: 27 Issue: 5 Pages: 369-383
- DOI
  10.1159/000277724
- NAID
  120002400574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390499, KAKENHI-PROJECT-22592076, KAKENHI-PROJECT-22791935
[Journal Article] Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K activation-dependent manner2010
- Author(s)
  Okubo, et.al
- Journal Title
  
  Journal of Vascular Research
  
  Volume: 47 Pages: 369-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791935
[Journal Article] Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K activation-dependent manner2010
- Author(s)
  Okubo, et.al
- Journal Title
  
  Journal of Vascular Research 47
  
  Pages: 369-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890240
[Journal Article] 歯根膜由来幹細胞様細胞による3次元培養下における血管内皮細胞マーカー陽性血管様構造の形成2009
- Author(s)
  大久保直登
- Journal Title
  
  口腔組織培養学会誌 19
  
  Pages: 29-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890240
[Patent] 疾患の潜在的罹患リスクが低い哺乳動物の生体組織を用いた生体材料2020
- Inventor(s)
  大久保直登, 細野秀崇
- Industrial Property Rights Holder
  大久保直登, 細野秀崇
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18H02997
[Patent] 疾患の潜在的罹患リスクが低い哺乳動物の生体組織を用いた生体材料2020
- Inventor(s)
  大久保　直登、細野　秀崇
- Industrial Property Rights Holder
  大久保　直登、細野　秀崇
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18H02997
[Patent] 医療用膜材料2019
- Inventor(s)
  大久保直登
- Industrial Property Rights Holder
  大久保直登
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02997
[Patent] 医療用膜材料2018
- Inventor(s)
  大久保　直登
- Industrial Property Rights Holder
  大久保　直登
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-137107
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02997
[Presentation] Dentin scaffold for onlay graft on atrophic mandible.2019
- Author(s)
  Murata M., Shakya M., Yokozeki K, Zhu B., Kusano K, Okubo N., Ishikawa M., Saito T.
- Organizer
  9th Annual Conference and Joint Scientific Meeting of Nepalese Association of Oral and Maxillofacial Surgeons (NAOMS) and Japanese Society of Oral and Maxillofacial Surgeons (JSOMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02997
[Presentation] TGF-β singal が歯根膜幹細胞による物理的収縮活性に与える影響2019
- Author(s)
  北爪教貴, 山田一輝, 長本香菜子, 赤澤敏之, 北川善政, 武田宏司, 大久保直登
- Organizer
  第23回生体関連セラミックス討論会
- Data Source
  KAKENHI-PROJECT-18H02997
[Presentation] 歯根膜組織由来上皮系幹細胞の機能評価2019
- Author(s)
  山田一輝, 北爪教貴, 長本香菜子, 赤澤敏之, 北川善政, 武田宏司, 大久保直登
- Organizer
  第23回生体関連セラミックス討論会
- Data Source
  KAKENHI-PROJECT-18H02997
[Presentation] Biological Adhesion of Different Biomaterials Designed by Periodontal Ligament Cells2019
- Author(s)
  Okubo N., Yokozeki K., Akazawa T., Murata M., Minamida Y., Kabir A., Ito M., Nakajima T
- Organizer
  The 13th Pacific Rim Conference of Ceramic Societies (PACRIM13)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02997
[Presentation] ラット歯根膜幹細胞由来筋線維芽細胞の収縮作用による歯周免疫機構への物理的関与．2017
- Author(s)
  大久保直登，村田　勝，赤澤敏之，中川宏治，帖佐直幸，武田宏司，石崎　明．
- Organizer
  第26回硬組織再生生物学会
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture.2017
- Author(s)
  Seiko Kyakumoto, Naoki Takizawa, Naoto Okubo, Masaharu Kamo, Naoyuki Chosa, Seiji Yokota, Masato Ohtsuka, Miho Ibi, Takashi Yaegashi, Akira Ishisaki
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] Mesenchymal stem cells educate undifferentiated monocyte/macrophages to the M2 macrophages in cell-cell adhesion-dependent and independent ways.2017
- Author(s)
  Naoki Takizawa, Naoto Okubo, Masaharu Kamo, Naoyuki Chosa, Toshinari Mikami, Keita Suzuki, Seiji Yokota, Miho Ibi, Masato Otuka, Masayuki Taira, Daisuke Sasaki, Takashi Yaegashi , Akira Ishisaki, Seiko Kyakumoto
- Organizer
  第65回国際歯科研究学会日本部会（JADR）学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] Bone induction on surface of rat compact bone treated with ultrasonic irradiation and acidic electrolyzed water.2017
- Author(s)
  Mamata Shakya, Masaru Murata, Kenji Yokozeki, Naoto Okubo, Toshiyuki Akazawa, Hiroki Nagayasu
- Organizer
  第26回硬組織再生生物学会
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] マウス骨髄由来間葉系幹細胞は共培養下で未分化単球／マクロファージ系細胞を CD206 陽性の免疫抑制性(M2)マクロファージに分化誘導する.2017
- Author(s)
  客本齊子、滝沢尚希、島　杏奈、帖佐直幸、加茂政晴、大久保直登、衣斐美歩、八重柏隆、石崎　明
- Organizer
  第57回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] マウス骨髄由来培養細胞において間葉系幹細胞は未分化単球／マクロファージを免疫抑制性マクロファージへと誘導する：細胞接着の関与.2017
- Author(s)
  客本斉子、滝沢尚希、大久保直登、鈴木啓太、帖佐直幸、衣斐美歩、加茂政晴、八重柏隆、石崎明
- Organizer
  第58回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] 自家象牙質移植による再生骨の組織学的証拠．2017
- Author(s)
  村田　勝，横関健治，Shakya Mamata，南田康人，草野　薫，大久保直登，赤澤敏之，永易裕樹．
- Organizer
  第26回硬組織再生生物学会
- Data Source
  KAKENHI-PROJECT-15K11234
[Presentation] サイトカイン様ペプチドSCRG１は間葉系幹細胞の骨ならびに脂肪分化を抑制する2013
- Author(s)
  青松恵美子　帖佐直幸　大久保直登　衣斐美歩　高橋典子　客本斉子　加茂政晴　長谷川智一佐藤和朗　三浦廣行　石崎明
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] EGFによるPDL由来EPCの増殖、分化制御2013
- Author(s)
  木村仁迪　大久保直登　帖佐直幸　衣斐美歩　客本斉子　加茂政晴　金野吉晃　三浦廣行　石崎明
- Organizer
  第55回歯科基礎医学会学術大会・総会
- Place of Presentation
  岡山・岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] EGFが歯周靭帯由来血管内皮前駆細胞の増殖と筋線維芽細胞分化に与える影響について2013
- Author(s)
  木村仁迪　大久保直登　帖佐直幸　衣斐美歩　客本斉子　加茂政晴　金野吉晃　三浦廣行　石崎明
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] TGF-βによる歯周靭帯由来血管内皮前駆細胞様細胞の増殖抑制と平滑筋細胞様分化のシグナル解析2012
- Author(s)
  客本斉子　吉田茉莉子　大久保直登　帖佐直幸　長谷川智一　高橋典子　衣斐美歩　加茂政晴　石崎明
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  奥羽大学　(福島県郡山市富田町)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] ファイブロサイトに注目した口腔領域疾患発症機構の解明2012
- Author(s)
  衣斐美歩　大久保直登　堀江沙和　帖佐直幸　吉田茉莉子　加茂政晴　客本斉子　大塚正人　　佐原資謹　藤村朗　石崎明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] ヒト口腔扁平上皮癌細胞におけるTGF-β1による上皮間葉転換に伴う細胞遊走能の解析2012
- Author(s)
  齋藤大嗣　帖佐直幸　客本斉子　高橋典子　大久保直登　衣斐美歩　水城春美　石崎明　加茂政晴
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] 間葉系幹細胞由来サイトカイン様ペプチドSCRG1は破骨細胞分化を抑制する2012
- Author(s)
  青松恵美子　帖佐直幸　大久保直登　衣斐美歩　高橋典子　客本斉子　加茂政晴　佐藤和朗三浦廣行　石崎明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] EGFが歯周靭帯由来血管内皮前駆細胞様細胞の増殖と筋線維芽細胞分化に与える影響について2012
- Author(s)
  木村仁迪　大久保直登　帖佐直幸　衣斐美歩　客本斉子　加茂政晴　金野吉晃　三浦廣行　石崎明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] 歯根膜由来内皮前駆細胞様線維芽細胞におけるTGF-β誘導性増殖抑制、平滑筋初期分化へのSmad ならびにp38 MAPK経路の関与2012
- Author(s)
  吉田茉莉子　大久保直登　帖佐直幸　長谷川智一　衣斐美歩　客本斉子　加茂政晴　石崎明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] TGF-βを介したヒト口腔扁平上皮癌細胞HSC-4における上皮間葉転換について2012
- Author(s)
  斎藤大嗣　帖佐直幸　客本斉子　高橋典子　大久保直登　衣斐美歩　水城春美　石崎明　加茂政晴
- Organizer
  日本分子生物学会第12回春季シンポジウム
- Place of Presentation
  石和温泉　慶山 (山梨県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] TGF-βとIGF-1、PDGFまたはVEGFの同時刺激は間葉系幹細胞の骨分化を促進する2012
- Author(s)
  横田潤　帖佐直幸　大久保直登　衣斐美歩　高橋典子　客本斉子　加茂政晴　近藤尚知　石崎明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] TGF-βにより誘導された上皮間葉転換に伴うヒト口腔扁平上皮癌細胞の細胞運動の解析2012
- Author(s)
  齋藤大嗣　帖佐直幸　客本斉子　高橋典子　大久保直登　衣斐美歩　石崎明　加茂政晴
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  奥羽大学　(福島県郡山市富田町)
- Data Source
  KAKENHI-PROJECT-24792149
[Presentation] 歯根膜由来幹細胞による血管内皮細胞マーカー陽性血管構造の構築2011
- Author(s)
  大久保直登
- Organizer
  北海道歯学会
- Place of Presentation
  札幌(歯学会賞受賞講演)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] TGF-β-induced smooth muscle cell differentiation of ligament-derived endothelial progenitor-like cells2011
- Author(s)
  Naoto Okubo
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] 歯根膜由来幹細胞による血管内皮細胞マーカー陽性血管構造の構築2011
- Author(s)
  大久保直登
- Organizer
  北海道歯学会
- Place of Presentation
  札幌
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] ラット歯根膜由来未分化間葉系細胞による血管様構造物の形成2010
- Author(s)
  大久保直登
- Organizer
  第2回『歯のバイオリサイクル医療の革新と海外ビジネス戦略』に係わる中間報告検討会
- Place of Presentation
  札幌
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] 歯根膜由来間葉系幹細胞による血管構造形成メカニズムの解明とキー遺伝子の同定2010
- Author(s)
  大久保直登
- Organizer
  岩手医科大学オープン・リサーチ・プロジェクト発表会
- Place of Presentation
  盛岡
- Year and Date
  2010-08-07
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] ラット歯根膜由来未分化間葉系細胞による血管様構造物の形成2010
- Author(s)
  大久保直登
- Organizer
  岩手医科大学歯学会第70回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] ラット歯根膜由来未分化間葉系細胞による血管様構造物の形成2010
- Author(s)
  大久保直登
- Organizer
  第2回『歯のバイオリサイクル医療の革新と海外ビジネス戦略』に係る中間報告検討会
- Place of Presentation
  札幌
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] 歯根膜由来間葉系細胞による血管内皮細胞マーカー陽性血管構造の形成2010
- Author(s)
  大久保直登
- Organizer
  第11回岩手軟骨懇話会
- Place of Presentation
  盛岡
- Year and Date
  2010-02-12
- Data Source
  KAKENHI-PROJECT-21890240
[Presentation] 歯根膜由来間葉系幹細胞による血管構造形成メカニズムの解明とキー遺伝子の同定2010
- Author(s)
  大久保直登
- Organizer
  岩手医科大学オープン・リサーチ・プロジェト発表会
- Place of Presentation
  盛岡
- Year and Date
  2010-08-07
- Data Source
  KAKENHI-PROJECT-22791935
[Presentation] 歯根膜由来幹細胞による血管内皮細胞マーカー陽性血管構造の形成2009
- Author(s)
  大久保直登
- Organizer
  第18回硬組織再生生物学会
- Place of Presentation
  札幌
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-21890240
[Presentation] 歯根膜由来幹細胞様細胞による3次元培養下における血管内皮細胞マーカー陽性血管様構造の形成2009
- Author(s)
  大久保直登
- Organizer
  第46回日本口腔組織培養学会学術大会・総会
- Place of Presentation
  東京
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21890240
[Presentation] 歯根膜由来未分化間葉系細胞幹細胞による血管内皮細胞マーカー陽性血管構造の形成2009
- Author(s)
  大久保直登
- Organizer
  第51回歯科基礎医学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21890240
[Presentation] ラット歯根膜由来間葉系幹細胞によるPI3K/Akt依存的なTie-2陽性血管構造の形成2009
- Author(s)
  大久保直登
- Organizer
  再生補綴医学研究会第2回学術会議
- Place of Presentation
  名古屋
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21890240
[Presentation] Establishment of a co-culture system for simultaneous proliferation of td-Tomato-expressing mouse bone marrow-derived mesenchymal stem cells and undifferentiated blood cells.
- Author(s)
  Naoki Takizawa, Seiko Kyakumoto, Naoto Okubo, Naoyuki Chosa, Miho Ibi, Hideaki Fujiwara, Masaharu Kamo1, Masato Otuka, Takashi Yaegashi , Akira Ishisaki.
- Organizer
  第37回日本分子生物学会・総会
- Place of Presentation
  福岡県福岡国際会議場
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24792149

1. 北川善政 (00224957)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. 大西俊介 (10443475)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 村田勝 (00260662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 須永隆文 (90649112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OHKAWARA Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TAKEDA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石崎明

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
8. 加茂政晴

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 帖佐直幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 飯塚正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 平雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 近藤尚知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okubo Naoto 大久保 直登

OKUBO Naoto 大久保 直登

Research Projects

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Therapeutic effect of gene-modified MSC-derived exosomes in liver fibrosis

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Development of Jawbone Regeneration Therapy Incorporating Soft Tissue Management Utilizing High-Performance Scaffolds.Principal Investigator

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The establishment of novel bone regenerative therapies utilizing the Periodontal ligament stem cells / demineralized Dentin matrix hybrid grafting materialsPrincipal Investigator

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Development of the tendon/ligament regenerative therapy utilizing human multipotent periodontal ligament stem cellsPrincipal Investigator

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Establishment of neovascularization-inducing technology accompanied with hematopoiesis by utilizing Periodontal ligament derived stem cellsPrincipal Investigator

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Identification of the key genes promoting angiogenesis and the signaling pathways regulating angiogenesis of the periodontal ligament derived stem cellsPrincipal Investigator

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歯根膜由来幹細胞による血管構造形成メカニズムの解明Principal Investigator

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[Book] Biomaterial-supported Tissue Reconstruction or Regeneration2019

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[Book] Tooth Materials Science and Clinical Applications (one chapter 担当)2015

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[Book] Advances in Oral Tissue Engineering2014

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[Journal Article] Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice2021

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[Journal Article] IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals.2018

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[Journal Article] IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals2018

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[Journal Article] In vitroにおける人参養栄湯のミトコンドリア量に対する作用.2018

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Okubo Naoto 大久保直登

OKUBO Naoto 大久保直登