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Nakagawa Hayato  中川 勇人

ORCIDConnect your ORCID iD *help
… Alternative Names

HAYATO NAKAGAWA  中川 勇人

中川 勇人  ナカガワ ハヤト

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Researcher Number 00555609
Other IDs
Affiliation (Current) 2025: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 三重大学, 医学系研究科, 教授
2021 – 2023: 東京大学, 医学部附属病院, 届出研究員
2013 – 2020: 東京大学, 医学部附属病院, 助教
2018: 東京大学, 医学部附属病院, 特任講師
2017: 東京大学, 医学部附属病院, その他
2011: The University of Tokyo, 医学部附属病院, その他
2010 – 2011: 東京大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Except Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords
Principal Investigator
肝細胞癌 / 非アルコール性脂肪肝炎 / 脂質生合成経路 / アシルカルニチン / NASH / 肝癌 / ICI関連肝障害 / 自己免疫性肝炎 / リン脂質 / リン脂質代謝異常 … More / リン脂質代謝 / 非アルコール性脂肪性肝疾患 / metabolic reprogramming / ビタミンD / 脂質代謝 / SREBP / メタボローム / 脂肪酸合成 / 脂質代謝リプログラミング / CPT2 / メタボリックリプログラミング / 炎症 / ERストレス / NASH … More
Except Principal Investigator
肝細胞癌 / 胆管癌 / 肝再生 / 胆管周囲付属腺 / バイオマーカー / 胆管再生 / 十二指腸乳頭部癌 / 癌起源細胞 / 肝外胆管癌 / オルガノイド / NASH / HCC / AFP / ラジオミクス / 胆汁酸 / 慢性肝疾患 / 分岐差アミノ酸 / 肝硬変 / 分岐鎖アミノ酸 / リトコール酸 / サルコペニア / 非典型PKC / 肝内胆管 / 非典型Protein Kinase C分子 / アラジール症候群 / 肝内胆管形成不全 / 非典型型Protein Kinase C / アラジール症候群(ALGS) / 十二指腸乳頭部 / 幹細胞ニッチ / 胆管幹細胞 / zonation / 肝発癌 / Wnt/βカテニンシグナル / metabolic zonation / 発癌起源 / ビタミンD誘導体 / 脂質生合成 / SREBP / 脂質生合成経路 / 個別化医療 / ゲノム異常 / ゲノム医療 / 血中循環腫瘍DNA / リキッドバイオプシー / 循環腫瘍DNA / cell free DNA / Rspo3 / Axin2 / 細胞系譜解析 / 混合型肝癌 / 腸内フローラ / 原発性硬化性胆管炎 / 潰瘍性大腸炎 / 硬化性胆管炎 / 腸内細菌叢 / 小腸 / 炎症性腸疾患 / 胆管炎 / マウスモデル / IL-33 / 門脈圧亢進症 / スフィンゴシン1リン酸 / 肝臓学 Less
  • Research Projects

    (19 results)
  • Research Products

    (77 results)
  • Co-Researchers

    (25 People)
  •  自己免疫性肝炎とICI関連肝障害の分子学的差異に基づく病態解明とバイオマーカー開発Principal Investigator

    • Principal Investigator
      中川 勇人
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Mie University
  •  Radio-Transcriptomicsによる肝癌の分子生物学的イメージング・バイオマーカーの構築

    • Principal Investigator
      藤原 直人
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Mie University
  •  AFP陽性細胞をターゲットとした新規NASH治療戦略の構築

    • Principal Investigator
      川村 聡
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Mie University
  •  胆汁酸を起点とした肝筋連関の解明と肝性サルコペニアの診断・治療

    • Principal Investigator
      岩佐 元雄
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Mie University
  •  Unraveling the Pathophysiology of NASH through Changes in LipoQualityPrincipal Investigator

    • Principal Investigator
      Nakagawa Hayato
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Mie University
  •  Cell fate analysis of Zone 3 hepatocytes and their potential as a cancer origin

    • Principal Investigator
      Wake Taijiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Establishment of a mouse model of ampullary carcinoma and identification of stem cell niches and cells of origin

    • Principal Investigator
      Hayata Yuki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  非典型PKC分子による肝内胆管形成の分子学的制御機構

    • Principal Investigator
      工藤 洋太郎
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Personalised treatment of advanced hepatocellular carcinoma using circulating tumor DNA

    • Principal Investigator
      Tateishi Ryosuke
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Development of novel therapies targeting lipid metabolism for cholangiocarcinoma

    • Principal Investigator
      Yamada Tomoharu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Investigation of the mechanisms of biliary epithelial regeneration and carcinogenesis focusing on the peribiliary glands

    • Principal Investigator
      Nakagomi Ryo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Intestinal microbiota as a therapeutic target of primary sclerosing cholangitis

    • Principal Investigator
      Kobayashi Yuka
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Investigation of the molecular mechanisms and cellular origins of combined hepatocellular-cholangiocarcinoma using hepatocellular carcinoma-specific gene recombination system in mice

    • Principal Investigator
      Uchino Koji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Molecular mechanisms and translational research in NASH and obesity-related liver cancer focusing on lipid metabolic reprogramingPrincipal Investigator

    • Principal Investigator
      Nakagawa Hayato
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The University of Tokyo
  •  Indentification of cancer initiating cells using a mouse model of cholangitis-associated cholangiocarcinoma

    • Principal Investigator
      Uchino Koji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  New therapeutic strategy for NASH-related HCC targeting lipid metabolismPrincipal Investigator

    • Principal Investigator
      Nakagawa Hayato
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Roles of inflammation- and stress-related signaling pathways in NASH-associated hepatocarcinogenesisPrincipal Investigator

    • Principal Investigator
      HAYATO NAKAGAWA
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  メタボリック症候群関連肝発癌における転写因子NF-kappaBの役割Principal Investigator

    • Principal Investigator
      中川 勇人
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  A novel treatment for liver injury by modulation oflipid mediator effects

    • Principal Investigator
      IKEDA Hitoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent Other

  • [Book] 消化器・肝臓内科 胆道上皮幹細胞と乳頭部腫瘍2022

    • Author(s)
      中川 勇人
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-21K08000
  • [Book] NASHの治療―薬物療法の現状と将来展望―2021

    • Author(s)
      中川勇人
    • Total Pages
      11
    • Publisher
      日本消化器病学会雑誌
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Journal Article] The translation of oncogenic mRNAs regulated by pseudouridylation: A new player in HCC2024

    • Author(s)
      Nakagawa Hayato、Lin Aifu
    • Journal Title

      Hepatology

      Volume: in press Issue: 5 Pages: 1003-1005

    • DOI

      10.1097/hep.0000000000000761

    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Journal Article] Effectiveness of 1-year pemafibrate treatment on steatotic liver disease: the influence of alcohol consumption2024

    • Author(s)
      Iwasa Motoh、Sugimoto Ryosuke、Eguchi Akiko、Tamai Yasuyuki、Shigefuku Ryuta、Fujiwara Naoto、Tanaka Hideaki、Kobayashi Yoshinao、Ikoma Jiro、Kaito Masahiko、Nakagawa Hayato
    • Journal Title

      European Journal of Gastroenterology & Hepatology

      Volume: in press Issue: 6 Pages: 793-801

    • DOI

      10.1097/meg.0000000000002766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Journal Article] Emerging role of spatial transcriptomics in liver research2024

    • Author(s)
      Fujiwara Naoto、Kimura Genki、Nakagawa Hayato
    • Journal Title

      Seminars in Liver Disease

      Volume: in press Issue: 02 Pages: 115-132

    • DOI

      10.1055/a-2299-7880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Journal Article] Combination Therapy of Immune Checkpoint Inhibitors with Locoregional Therapy for Hepatocellular Carcinoma2023

    • Author(s)
      Tamai Yasuyuki、Fujiwara Naoto、Tanaka Takamitsu、Mizuno Shugo、Nakagawa Hayato
    • Journal Title

      Cancers

      Volume: 15 Issue: 20 Pages: 5072-5072

    • DOI

      10.3390/cancers15205072

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K16770, KAKENHI-PROJECT-21H02892
  • [Journal Article] Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma2023

    • Author(s)
      Yamada Tomoharu、Fujiwara Naoto、Kubota Naoto、Matsushita Yuki、Nakatsuka Takuma、Kurosaki Shigeyuki、Minami Tatsuya、Tateishi Ryosuke、Ichida Akihiko、Arita Junichi、Hasegawa Kiyoshi、Koike Kazuhiko、Fujishiro Mitsuhiro、Nakagawa Hayato
    • Journal Title

      Hepatology Communications

      Volume: 7 Issue: 8

    • DOI

      10.1097/hc9.0000000000000209

    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Journal Article] A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis.2022

    • Author(s)
      Eguchi A, Iwasa M, Yamada M, Tamai Y, Shigefuku R, Hasegawa H, Hirokawa Y, Hayashi A, Okuno K, Matsushita Y, Nakatsuka T, Enooku K, Sakaguchi K, Kobayashi Y, Yamaguchi T, Watanabe M, Takei Y, Nakagawa H.
    • Journal Title

      Hepatol Commun.

      Volume: 6 Issue: 8 Pages: 1987-1999

    • DOI

      10.1002/hep4.1971

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Journal Article] Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans2022

    • Author(s)
      Tamai Yasuyuki、Eguchi Akiko、Shigefuku Ryuta、Kitamura Hiroshi、Tempaku Mina、Sugimoto Ryosuke、Kobayashi Yoshinao、Iwasa Motoh、Takei Yoshiyuki、Nakagawa Hayato
    • Journal Title

      eLife

      Volume: 11

    • DOI

      10.7554/elife.80638

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06001, KAKENHI-PROJECT-21H02892
  • [Journal Article] Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis2022

    • Author(s)
      Kawamura Satoshi、Matsushita Y、Kurosaki S、Tange M、Fujiwara N、Hayata Y、Hayakawa Y、Suzuki N、Hata M、Tsuboi M、Kishikawa T、Kinoshita H、Nakatsuka T、Sato M、Kudo Y、Hoshida Y、Umemura A、Eguchi A、Ikenoue T、Hirata Y、Uesugi M、Tateishi R、Tateishi Keisuke、Fujishiro Mitsuhiro、Koike K、Nakagawa H
    • Journal Title

      Journal of Clinical Investigation

      Volume: 132 Issue: 11

    • DOI

      10.1172/jci151895

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08028, KAKENHI-PROJECT-21H02892
  • [Journal Article] Radiofrequency Ablation of Liver Tumors in Patients on Antithrombotic Therapy: A Case-Control Analysis of over 10,000 Treatments2021

    • Author(s)
      Uchino Koji、Tateishi Ryosuke、Wake Taijiro、Kinoshita Mizuki Nishibatake、Nakagomi Ryo、Nakatsuka Takuma、Minami Tatsuya、Sato Masaya、Enooku Kenichiro、Nakagawa Hayato、Shiina Shuichiro、Koike Kazuhiko
    • Journal Title

      Journal of Vascular and Interventional Radiology

      Volume: - Issue: 6 Pages: 869-877

    • DOI

      10.1016/j.jvir.2021.02.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Journal Article] Discovery of a VDR-Silent Vitamin D Derivative That Impairs SREBP in Vivo.2021

    • Author(s)
      1.Kawagoe F, Mendoza A, Hayata Y, Asano L, Kotate K, Mototani S, Kawamura S, Kurosaki S, Akagi Y, Takemoto Y, Nagasawa K, Nakagawa H, Uesugi M, Kittaka A.
    • Journal Title

      J Med Chem.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Journal Article] Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging2021

    • Author(s)
      Nao Nagai, Yotaro Kudo, Daisuke Aki, Hayato Nakagawa, Koji Taniguchi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 5 Pages: 2238-2238

    • DOI

      10.3390/ijms22052238

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07629, KAKENHI-PROJECT-18H02789, KAKENHI-PROJECT-19K23850, KAKENHI-PROJECT-15K21775, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279
  • [Journal Article] Lipid Metabolism in Oncology: Why It Matters, How to Research, and How to Treat.2021

    • Author(s)
      Matsushita Y, Nakagawa H, Koike K.
    • Journal Title

      Cancers (Basel).

      Volume: 13 Issue: 3 Pages: 474-474

    • DOI

      10.3390/cancers13030474

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Journal Article] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021

    • Author(s)
      Nakatsuka T、Nakagawa H、Hayata Y、Wake T、Yamada T、Nishibatake Kinoshita M、Nakagmi R、Sato M、Minami T、Uchino K、Enooku K、Kudo Y、Tanaka Y、Kishikawa T、Otsuka M、Tateishi R、Koike K
    • Journal Title

      Journal of Gastroenterology

      Volume: - Issue: 5 Pages: 01773-4

    • DOI

      10.1007/s00535-021-01773-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-18H02789, KAKENHI-PROJECT-18K07900, KAKENHI-PROJECT-21K07906
  • [Journal Article] Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma2019

    • Author(s)
      Enooku Kenichiro、Nakagawa Hayato、Fujiwara Naoto、Kondo Mayuko、Minami Tatsuya、Hoshida Yujin、Shibahara Junji、Tateishi Ryosuke、Koike Kazuhiko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41598-019-47216-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Journal Article] CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity2018

    • Author(s)
      Fujiwara Naoto、Nakagawa Hayato、Enooku Kenichiro、Otsuka Motoyuki、Tateishi Keisuke、Koike Kazuhiko
    • Journal Title

      Gut

      Volume: 67 Issue: 8 Pages: 1493-1504

    • DOI

      10.1136/gutjnl-2017-315193

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313, KAKENHI-PROJECT-16K19075, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-16K09342
  • [Journal Article] Lipid Metabolic Reprogramming in Hepatocellular Carcinoma.2018

    • Author(s)
      Nakagawa H, Hayata Y, Kawamura S, Yamada T, Fujiwara N, Koike K.
    • Journal Title

      Cancers

      Volume: 10 Issue: 11 Pages: 447-447

    • DOI

      10.3390/cancers10110447

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Journal Article] Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.2017

    • Author(s)
      Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114(19) Issue: 19

    • DOI

      10.1073/pnas.1619416114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15107, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K09038, KAKENHI-PROJECT-15K09039
  • [Journal Article] p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells2016

    • Author(s)
      Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M
    • Journal Title

      Cancer Cell

      Volume: 29 Issue: 6 Pages: 935-948

    • DOI

      10.1016/j.ccell.2016.04.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313
  • [Journal Article] How endoplasmic reticulum stress contributes to obesity-driven hepatic tumorigenesis.2015

    • Author(s)
      Nakagawa H
    • Journal Title

      Hepat. Oncol.

      Volume: 2 Pages: 209-11

    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Journal Article] Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.2015

    • Author(s)
      6.Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M.
    • Journal Title

      Cell

      Volume: 162 Issue: 4 Pages: 766-79

    • DOI

      10.1016/j.cell.2015.07.026

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Journal Article] Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis.2015

    • Author(s)
      Nakagawa H
    • Journal Title

      World J Hepatol.

      Volume: 18 Issue: 17 Pages: 2110-8

    • DOI

      10.4254/wjh.v7.i17.2110

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Journal Article] ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development2014

    • Author(s)
      Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M.
    • Journal Title

      Cancer Cell

      Volume: 26 Issue: 3 Pages: 331-343

    • DOI

      10.1016/j.ccr.2014.07.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25893042
  • [Journal Article] Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.2014

    • Author(s)
      Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 3 Pages: 1090-1095

    • DOI

      10.1073/pnas.1322731111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390092, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25290045, KAKENHI-PROJECT-25670186, KAKENHI-PROJECT-25893042
  • [Patent] 4.脂肪性肝疾患の検出又はリスクの予測方法、脂肪性肝疾患を検出するための診断薬キット及びバイオマーカー2018

    • Inventor(s)
      中川勇人
    • Industrial Property Rights Holder
      中川勇人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Patent] 3.NAFLD又はNASHの検出又はリスクの予測方法、NAFLD又はNASHを検出するための診断薬キット2018

    • Inventor(s)
      中川勇人
    • Industrial Property Rights Holder
      中川勇人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Patent] NAFLD又はNASHの検出又はリスクの予測方法、NAFLD又はNASHを検出するための診断薬キット及び対象における肝線維化の進行度を判定するための診断薬キット2018

    • Inventor(s)
      中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
    • Industrial Property Rights Holder
      中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Patent] 脂肪性肝疾患の検出又はリスクの予測方法、脂肪性肝疾患を検出するための診断薬キット2018

    • Inventor(s)
      中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
    • Industrial Property Rights Holder
      中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] 肝細胞癌における微小環境解析の最新知見2024

    • Author(s)
      中川勇人
    • Organizer
      第82回癌学会総会 シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07887
  • [Presentation] Unveiling the Cellular Origins and Therapeutic Targets in Extrahepatic Cholangiocarcinoma: Insights from Mouse Models and Genetic Markers.2024

    • Author(s)
      Nakagawa Hayato
    • Organizer
      APASL
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08000
  • [Presentation] AFP-expressing hepatocytes function as hepatic stem cells that give rise to liver cancer2024

    • Author(s)
      Kawamura S, Tempaku M, Kimura G, Izuoka K, Tachi Y, Fujiwara N, Eguchi A, Nakagawa H
    • Organizer
      アジア太平洋肝臓学会(APASL)2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07456
  • [Presentation] 主題:肝硬変合併症の基礎と臨床 リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023

    • Author(s)
      江口暁子 岩佐元雄 中川勇人
    • Organizer
      日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-22K08011
  • [Presentation] 個別化医療を見据えたNAFLD肝生検組織の網羅的transcriptome解析2023

    • Author(s)
      中川勇人
    • Organizer
      第59回肝臓学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] 主題:肝疾患の病態に基づいた治療戦略 慢性肝疾患に伴う骨格筋障害における肝細胞由来臓器間病態伝達体の役割2023

    • Author(s)
      江口暁子 岩佐元雄 中川勇人
    • Organizer
      日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-22K08011
  • [Presentation] Molecular mechanisms and cellular origins of biliary tract cancer: cutting-edge knowledge from mouse models.2023

    • Author(s)
      Nakagawa Hayato
    • Organizer
      APASL Oncology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08000
  • [Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変ラットやヒトの骨格筋量増加に寄与する2023

    • Author(s)
      江口暁子 岩佐元雄 中川勇人
    • Organizer
      日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-22K08011
  • [Presentation] AFP陽性細胞の肝再生への寄与と発癌起源としての可能性2023

    • Author(s)
      川村聡、藤原直人、天白美奈、江口暁子、中川勇人
    • Organizer
      第8回Gastro-PLUS
    • Data Source
      KAKENHI-PROJECT-23K07456
  • [Presentation] 肝細胞癌における微小環境解析の最新知見2023

    • Author(s)
      中川勇人
    • Organizer
      第82回癌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023

    • Author(s)
      江口暁子 岩佐元雄 中川勇人
    • Organizer
      日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-22K08011
  • [Presentation] Peribiliary glands generate biliary epithelial stem cell niche as well as origin of biliary tract cancer.2023

    • Author(s)
      Nakagawa Hayato
    • Organizer
      第59回肝臓学会総会 JSH-EASL Joint Session
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K08000
  • [Presentation] ラジオ波焼灼術後の腫瘍検体と血漿を用いた肝癌ゲノム解析の可能性2022

    • Author(s)
      中塚拓馬、中川勇人、森山慎、福本剛、山田友春、和気泰次郎、佐藤雅哉、南達也、工藤洋太郎、建石良介
    • Organizer
      第1回 日本アブレーション研究会
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] Lipid Metabolism in NASH and NASH-related hepatocellular carcinoma.2022

    • Author(s)
      中川勇人
    • Organizer
      第81回癌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] Genomic and molecular profiling-based personalized medicine for liver cancer.2022

    • Author(s)
      Nakagawa H
    • Organizer
      APASL Oncology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] Liver Cancer Research - Host Genome, Immunity and Pathology - Summary & Prospects2022

    • Author(s)
      中川勇人
    • Organizer
      第58回肝臓学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] 肝癌におけるラジオ波焼灼後腫瘍生検の臨床的有用性および遺伝子変異解析の可能性2022

    • Author(s)
      中塚拓馬、内野康志、中川勇人、森山慎、福本剛、山田友春、和気泰次郎、佐藤雅哉、南達也、工藤洋太郎、建石良介、藤城光弘
    • Organizer
      第58回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] Inhibition of SCAP/SREBP-mediated lipogenesis exacerbates liver injury and carcinogenesis in murine NASH via phospholipid metabolism disturbance.2021

    • Author(s)
      Kawamura S, Nakagawa H, Koike K.
    • Organizer
      American Association for the Study of Liver Diseases (AASLD)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] Lipogenic pathway in NAFLD and NAFLD-related HCC: Friend or Foe?2021

    • Author(s)
      Nakagawa H
    • Organizer
      第57回肝臓学会総会JSH-AASLD Joint Session.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] Digital Spatial Profiling技術を用いたレンバチニブ投与後の腫瘍内免疫微小環境変化の検討.2021

    • Author(s)
      山田友春、中川勇人、小池和彦
    • Organizer
      第57回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] AXIN2+ PERIBILIARY GLAND CELLS IN PERIAMPULLARY REGION SERVE AS BILIARY EPITHELIAL STEM CELLS AND GIVE RISE TO AMPULLARY CARCINOMA.2021

    • Author(s)
      Hayata Y, Nakagawa H, Koike K.
    • Organizer
      Digestive Disease Week (DDW) 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08000
  • [Presentation] Post-treatment cell-free DNA as a predictive biomarker in systemic therapy for HCC2021

    • Author(s)
      Takuma Nakatsuka, Hayato Nakagawa, Taijiro Wake, Tomoharu Yamada, Masaya Sato, Tatsuya Minami, Yotaro Kudo, Yasuo Tanaka, Motoyuki Otsuka, Ryosuke Tateishi, Kazuhiko Koike
    • Organizer
      APASL Oncology 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021

    • Author(s)
      Takuma Nakatsuka, Hayato Nakagawa, Yuki Hayata, Taijiro Wake, Tomoharu Yamada, Ryo Nakagomi, Masaya Sato, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Yotaro Kudo, Yasuo Tanaka, Motoyuki Otsuka, Ryosuke Tateishi, Kazuhiko Koike
    • Organizer
      JSH International Liver Conference 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] Wnt/βカテニン経路活性化ニッチを標的とした肝発癌予防の可能性.2021

    • Author(s)
      黒崎滋之、中川勇人、小池和彦.
    • Organizer
      第57回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] Unexpected exacerbation of liver injury and carcinogenesis by inhibiting SCAP/SREBP in murine NASH.2021

    • Author(s)
      中川勇人
    • Organizer
      第80回癌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02892
  • [Presentation] ケミカルバイオロジーに基づくNAFLDに対する新規治療法の創出;人工ビタミンD誘導体による脂肪肝抑制効果2020

    • Author(s)
      中川勇人、小池和彦
    • Organizer
      第56回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] 治療後 cell-free DNA 解析による分子標的薬の治療効果予測2020

    • Author(s)
      中塚拓馬、中川勇人、早田有希、和気泰次郎、山田友春、木下瑞希、中込良、 佐藤雅哉、南達也、榎奥健一郎、工藤洋太郎、田中康雄、大塚基之、建石良介、小池和彦
    • Organizer
      第23回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] 治療後cell-free DNA解析による肝癌ゲノム医療に向けた試み2020

    • Author(s)
      中塚拓馬、中川勇人、小池和彦
    • Organizer
      第28回日本消化器関連学会週間(JDDW 2020)
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] Circulating tumor DNA 解析による肝癌層別化治療に向けた試み2020

    • Author(s)
      中塚拓馬、中川勇人、小池和彦
    • Organizer
      第56回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K08352
  • [Presentation] Inhibition of SCAP/SREBP-mediated lipogenesis exacerbates liver injury in murine NASH model via disturbance of phospholipid metabolism.2020

    • Author(s)
      Kawamura S, Nakagawa H, Koike K
    • Organizer
      JDDW2020
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] 2.Clinical applications of liquid biopsy as a novel biomarker in hepatocellular carcinoma.2019

    • Author(s)
      Takuma Nakatsuka, Hayato Nakagawa, Kazuhiko Koike
    • Organizer
      JDDW International Session
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] NASH・肥満関連肝癌におけるlipid metabolic reprogramming2019

    • Author(s)
      中川勇人、小池和彦
    • Organizer
      第6回肝臓と糖尿病・代謝研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] 4.Metabolic reprogramming in hepatocellular carcinoma for adaptation to lipid-rich environment.2019

    • Author(s)
      Hayato Nakagawa
    • Organizer
      JSH-EASL Joint Session
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] 3.NASH・肥満関連肝癌に特異的な脂質代謝リプログラミングに基づく病態解明とバイオマーカー探索2019

    • Author(s)
      中川勇人、小池和彦
    • Organizer
      第55回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] NASH病態進展における脂質生合成経路の役割2019

    • Author(s)
      川村聡、中川勇人、小池和彦
    • Organizer
      第27回JDDW
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] 癌種特異的脂質代謝リプログラミングを標的とした新規治療戦略2018

    • Author(s)
      中川勇人、小池和彦
    • Organizer
      第5回肝臓と糖尿病・代謝研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] NAFLD患者241症例における血清アシルカルニチン精密分析2018

    • Author(s)
      中川勇人、榎奥健一郎、小池和彦
    • Organizer
      酸化ストレスと肝研究会
    • Data Source
      KAKENHI-PROJECT-18H02789
  • [Presentation] NASH・肥満関連肝癌における特異的代謝変化に着目した発癌促進機構解明2017

    • Author(s)
      藤原直人、中川勇人、小池和彦
    • Organizer
      第53回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Presentation] 2.Obesity-driven HCC adapts to lipid-rich conditions by CPT2 downregulatin and promotes carcinogenesis through acylcarnitine accumulation.2017

    • Author(s)
      Naoto Fujiwara, Hayato Nakagawa, Kenichiro Enooku, Kazuhiko Koike
    • Organizer
      American Association for the Study of Liver Diseases (AASLD) anual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Presentation] Novel mouse model of NASH-driven HCC whose progression depends on TNF-IKK pathway.2016

    • Author(s)
      Hayato Nakagawa, Kazuhiko Koike
    • Organizer
      APASL 2016
    • Place of Presentation
      東京
    • Year and Date
      2016-02-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Presentation] C型慢性肝炎におけるアディポネクチン・パラドックス.2015

    • Author(s)
      中川勇人、藤原直人、小池和彦
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Presentation] The vicious cycle of ER stress and steatosis in NASH progression2015

    • Author(s)
      Hayato Nakagawa, Atsushi Umemura, Kazuhiko Koike, Michael Karin
    • Organizer
      JDDW 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19313
  • [Presentation] 新規マウスモデルを用いたNASH発癌機構の解明2014

    • Author(s)
      中川勇人、小池和彦
    • Organizer
      肝臓と糖尿病・代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-04
    • Data Source
      KAKENHI-PROJECT-25893042
  • [Presentation] 新規マウスモデルを用いたNASH肝癌におけるTNFαの役割解析

    • Author(s)
      中川勇人、小池和彦
    • Organizer
      JDDW2013
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Data Source
      KAKENHI-PROJECT-25893042
  • []

  • []

  • []

  • []

  • 1.  Uchino Koji (00748725)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  中塚 拓馬 (50772042)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 3.  工藤 洋太郎 (90608358)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  藤原 直人 (40971693)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  IKEDA Hitoshi (80202422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TOMIYA Tomoaki (90227637)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Kobayashi Yuka (80724658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Nakagomi Ryo (20778039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Tateishi Ryosuke (50444089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 10.  Yamada Tomoharu (60868024)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Wake Taijiro (60895267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Hayata Yuki (60897883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  木下 裕人 (50645322)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  田中 康雄 (40422290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 15.  岩佐 元雄 (80378299)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 16.  江口 暁子 (00598980)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 17.  浅岡 良成 (90431858)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  川村 聡 (90930868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 19.  小池 和彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 20.  西川 祐司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 21.  北村 浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  玉井 康将
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  安藝 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  畑 昌宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  鈴木 伸三
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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