Nakagawa Hayato 中川勇人

… Alternative Names

HAYATO NAKAGAWA 中川勇人

中川勇人ナカガワハヤト

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Researcher Number	00555609
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 三重大学, 医学系研究科, 教授 2021 – 2023: 東京大学, 医学部附属病院, 届出研究員 2013 – 2020: 東京大学, 医学部附属病院, 助教 2018: 東京大学, 医学部附属病院, 特任講師 2017: 東京大学, 医学部附属病院, その他 2011: The University of Tokyo, 医学部附属病院, その他 2010 – 2011: 東京大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 肝細胞癌 / 非アルコール性脂肪肝炎 / 脂質生合成経路 / アシルカルニチン / NASH / 肝癌 / ICI関連肝障害 / 自己免疫性肝炎 / リン脂質 / リン脂質代謝異常 … More / リン脂質代謝 / 非アルコール性脂肪性肝疾患 / metabolic reprogramming / ビタミンD / 脂質代謝 / SREBP / メタボローム / 脂肪酸合成 / 脂質代謝リプログラミング / CPT2 / メタボリックリプログラミング / 炎症 / ERストレス / ＮＡＳＨ … More Except Principal Investigator 肝細胞癌 / 胆管癌 / 肝再生 / 癌起源細胞 / 胆管周囲付属腺 / バイオマーカー / 胆管再生 / 十二指腸乳頭部癌 / 肝外胆管癌 / オルガノイド / β-catenin / ドライバー遺伝子変異 / NASH / HCC / AFP / ラジオミクス / 胆汁酸 / 慢性肝疾患 / 分岐差アミノ酸 / 肝硬変 / 分岐鎖アミノ酸 / リトコール酸 / サルコペニア / 非典型PKC / 肝内胆管 / 非典型Protein Kinase C分子 / アラジール症候群 / 肝内胆管形成不全 / 非典型型Protein Kinase C / アラジール症候群（ALGS） / 十二指腸乳頭部 / 幹細胞ニッチ / 胆管幹細胞 / zonation / 肝発癌 / Wnt/βカテニンシグナル / metabolic zonation / 発癌起源 / ビタミンD誘導体 / 脂質生合成 / SREBP / 脂質生合成経路 / 個別化医療 / ゲノム異常 / ゲノム医療 / 血中循環腫瘍DNA / リキッドバイオプシー / 循環腫瘍DNA / cell free DNA / Rspo3 / Axin2 / 細胞系譜解析 / 混合型肝癌 / 腸内フローラ / 原発性硬化性胆管炎 / 潰瘍性大腸炎 / 硬化性胆管炎 / 腸内細菌叢 / 小腸 / 炎症性腸疾患 / 胆管炎 / マウスモデル / IL-33 / 門脈圧亢進症 / スフィンゴシン1リン酸 / 肝臓学 Less

癌遺伝子変異肝細胞を標的とした発癌抑制システムの解析と新規治療戦略構築
- Principal Investigator
  
  早田有希
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
自己免疫性肝炎とICI関連肝障害の分子学的差異に基づく病態解明とバイオマーカー開発Principal Investigator
- Principal Investigator
  
  中川勇人
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
Radio-Transcriptomicsによる肝癌の分子生物学的イメージング・バイオマーカーの構築
- Principal Investigator
  
  藤原直人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
AFP陽性細胞をターゲットとした新規NASH治療戦略の構築
- Principal Investigator
  
  川村聡
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
胆汁酸を起点とした肝筋連関の解明と肝性サルコペニアの診断・治療
- Principal Investigator
  
  岩佐元雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
Unraveling the Pathophysiology of NASH through Changes in LipoQualityPrincipal Investigator
- Principal Investigator
  
  Nakagawa Hayato
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
Cell fate analysis of Zone 3 hepatocytes and their potential as a cancer origin
- Principal Investigator
  
  Wake Taijiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Establishment of a mouse model of ampullary carcinoma and identification of stem cell niches and cells of origin
- Principal Investigator
  
  Hayata Yuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
非典型PKC分子による肝内胆管形成の分子学的制御機構
- Principal Investigator
  
  工藤洋太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Personalised treatment of advanced hepatocellular carcinoma using circulating tumor DNA
- Principal Investigator
  
  Tateishi Ryosuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Development of novel therapies targeting lipid metabolism for cholangiocarcinoma
- Principal Investigator
  
  Yamada Tomoharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Investigation of the mechanisms of biliary epithelial regeneration and carcinogenesis focusing on the peribiliary glands
- Principal Investigator
  
  Nakagomi Ryo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Intestinal microbiota as a therapeutic target of primary sclerosing cholangitis
- Principal Investigator
  
  Kobayashi Yuka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Investigation of the molecular mechanisms and cellular origins of combined hepatocellular-cholangiocarcinoma using hepatocellular carcinoma-specific gene recombination system in mice
- Principal Investigator
  
  Uchino Koji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Molecular mechanisms and translational research in NASH and obesity-related liver cancer focusing on lipid metabolic reprogramingPrincipal Investigator
- Principal Investigator
  
  Nakagawa Hayato
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Indentification of cancer initiating cells using a mouse model of cholangitis-associated cholangiocarcinoma
- Principal Investigator
  
  Uchino Koji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
New therapeutic strategy for NASH-related HCC targeting lipid metabolismPrincipal Investigator
- Principal Investigator
  
  Nakagawa Hayato
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Roles of inflammation- and stress-related signaling pathways in NASH-associated hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  HAYATO NAKAGAWA
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
メタボリック症候群関連肝発癌における転写因子NF-kappaBの役割Principal Investigator
- Principal Investigator
  
  中川勇人
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
A novel treatment for liver injury by modulation oflipid mediator effects
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent

[Book] 消化器・肝臓内科胆道上皮幹細胞と乳頭部腫瘍2022
- Author(s)
  中川勇人
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21K08000
[Book] NASHの治療―薬物療法の現状と将来展望―2021
- Author(s)
  中川勇人
- Total Pages
  11
- Publisher
  日本消化器病学会雑誌
- Data Source
  KAKENHI-PROJECT-21H02892
[Journal Article] The translation of oncogenic mRNAs regulated by pseudouridylation: A new player in HCC2024
- Author(s)
  Nakagawa Hayato、Lin Aifu
- Journal Title
  
  Hepatology
  
  Volume: in press Issue: 5 Pages: 1003-1005
- DOI
  10.1097/hep.0000000000000761
- Data Source
  KAKENHI-PROJECT-21H02892
[Journal Article] Effectiveness of 1-year pemafibrate treatment on steatotic liver disease: the influence of alcohol consumption2024
- Author(s)
  Iwasa Motoh、Sugimoto Ryosuke、Eguchi Akiko、Tamai Yasuyuki、Shigefuku Ryuta、Fujiwara Naoto、Tanaka Hideaki、Kobayashi Yoshinao、Ikoma Jiro、Kaito Masahiko、Nakagawa Hayato
- Journal Title
  
  European Journal of Gastroenterology & Hepatology
  
  Volume: in press Issue: 6 Pages: 793-801
- DOI
  10.1097/meg.0000000000002766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02892
[Journal Article] Emerging role of spatial transcriptomics in liver research2024
- Author(s)
  Fujiwara Naoto、Kimura Genki、Nakagawa Hayato
- Journal Title
  
  Seminars in Liver Disease
  
  Volume: in press Issue: 02 Pages: 115-132
- DOI
  10.1055/a-2299-7880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02892
[Journal Article] Combination Therapy of Immune Checkpoint Inhibitors with Locoregional Therapy for Hepatocellular Carcinoma2023
- Author(s)
  Tamai Yasuyuki、Fujiwara Naoto、Tanaka Takamitsu、Mizuno Shugo、Nakagawa Hayato
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 20 Pages: 5072-5072
- DOI
  10.3390/cancers15205072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16770, KAKENHI-PROJECT-21H02892
[Journal Article] Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma2023
- Author(s)
  Yamada Tomoharu、Fujiwara Naoto、Kubota Naoto、Matsushita Yuki、Nakatsuka Takuma、Kurosaki Shigeyuki、Minami Tatsuya、Tateishi Ryosuke、Ichida Akihiko、Arita Junichi、Hasegawa Kiyoshi、Koike Kazuhiko、Fujishiro Mitsuhiro、Nakagawa Hayato
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 8
- DOI
  10.1097/hc9.0000000000000209
- Data Source
  KAKENHI-PROJECT-21H02892
[Journal Article] A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis.2022
- Author(s)
  Eguchi A, Iwasa M, Yamada M, Tamai Y, Shigefuku R, Hasegawa H, Hirokawa Y, Hayashi A, Okuno K, Matsushita Y, Nakatsuka T, Enooku K, Sakaguchi K, Kobayashi Y, Yamaguchi T, Watanabe M, Takei Y, Nakagawa H.
- Journal Title
  
  Hepatol Commun.
  
  Volume: 6 Issue: 8 Pages: 1987-1999
- DOI
  10.1002/hep4.1971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02892
[Journal Article] Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans2022
- Author(s)
  Tamai Yasuyuki、Eguchi Akiko、Shigefuku Ryuta、Kitamura Hiroshi、Tempaku Mina、Sugimoto Ryosuke、Kobayashi Yoshinao、Iwasa Motoh、Takei Yoshiyuki、Nakagawa Hayato
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.80638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06001, KAKENHI-PROJECT-21H02892
[Journal Article] Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis2022
- Author(s)
  Kawamura Satoshi、Matsushita Y、Kurosaki S、Tange M、Fujiwara N、Hayata Y、Hayakawa Y、Suzuki N、Hata M、Tsuboi M、Kishikawa T、Kinoshita H、Nakatsuka T、Sato M、Kudo Y、Hoshida Y、Umemura A、Eguchi A、Ikenoue T、Hirata Y、Uesugi M、Tateishi R、Tateishi Keisuke、Fujishiro Mitsuhiro、Koike K、Nakagawa H
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 11
- DOI
  10.1172/jci151895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08028, KAKENHI-PROJECT-21H02892
[Journal Article] Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals2021
- Author(s)
  Minami Tatsuya、Tateishi Ryosuke、Nakatsuka Takuma、Nakagawa Hayato、et al.
- Journal Title
  
  Liver Cancer
  
  Volume: 10 Issue: 4 Pages: 309
- DOI
  10.1159/000513705
- URL
  https://pure.teikyo.jp/en/publications/9501b6f6-f3aa-4d05-8db6-86c10b130078
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-21K07906
[Journal Article] Radiofrequency Ablation of Liver Tumors in Patients on Antithrombotic Therapy: A Case-Control Analysis of over 10,000 Treatments2021
- Author(s)
  Uchino Koji、Tateishi Ryosuke、Wake Taijiro、Kinoshita Mizuki Nishibatake、Nakagomi Ryo、Nakatsuka Takuma、Minami Tatsuya、Sato Masaya、Enooku Kenichiro、Nakagawa Hayato、Shiina Shuichiro、Koike Kazuhiko
- Journal Title
  
  Journal of Vascular and Interventional Radiology
  
  Volume: - Issue: 6 Pages: 869-877
- DOI
  10.1016/j.jvir.2021.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352
[Journal Article] Discovery of a VDR-Silent Vitamin D Derivative That Impairs SREBP in Vivo.2021
- Author(s)
  1.Kawagoe F, Mendoza A, Hayata Y, Asano L, Kotate K, Mototani S, Kawamura S, Kurosaki S, Akagi Y, Takemoto Y, Nagasawa K, Nakagawa H, Uesugi M, Kittaka A.
- Journal Title
  
  J Med Chem.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02789
[Journal Article] Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging2021
- Author(s)
  Nao Nagai, Yotaro Kudo, Daisuke Aki, Hayato Nakagawa, Koji Taniguchi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2238-2238
- DOI
  10.3390/ijms22052238
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07629, KAKENHI-PROJECT-18H02789, KAKENHI-PROJECT-19K23850, KAKENHI-PROJECT-15K21775, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279
[Journal Article] Lipid Metabolism in Oncology: Why It Matters, How to Research, and How to Treat.2021
- Author(s)
  Matsushita Y, Nakagawa H, Koike K.
- Journal Title
  
  Cancers (Basel).
  
  Volume: 13 Issue: 3 Pages: 474-474
- DOI
  10.3390/cancers13030474
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02789
[Journal Article] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021
- Author(s)
  Nakatsuka T、Nakagawa H、Hayata Y、Wake T、Yamada T、Nishibatake Kinoshita M、Nakagmi R、Sato M、Minami T、Uchino K、Enooku K、Kudo Y、Tanaka Y、Kishikawa T、Otsuka M、Tateishi R、Koike K
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Issue: 5 Pages: 01773-4
- DOI
  10.1007/s00535-021-01773-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-18H02789, KAKENHI-PROJECT-18K07900, KAKENHI-PROJECT-21K07906
[Journal Article] Infectious complications related to radiofrequency ablation of liver tumors: The role of antibiotics2021
- Author(s)
  Nakagomi Ryo、Tateishi Ryosuke、Mikami Shintaro、Wake Taijiro、Kinoshita Mizuki Nishibatake、Nakatsuka Takuma、Minami Tatsuya、Sato Masaya、Uchino Koji、Enooku Kenichiro、Nakagawa Hayato、Asaoka Yoshinari、Shiina Shuichiro、Koike Kazuhiko
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 11 November Pages: 0259641-0259641
- DOI
  10.1371/journal.pone.0259641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352
[Journal Article] Improved liver function in patients with cirrhosis due to chronic hepatitis C virus who achieve sustained virologic response is not accompanied by increased liver volume2020
- Author(s)
  Wake Taijiro、Tateishi Ryosuke、Fukumoto Tsuyoshi、Nakagomi Ryo、Kinoshita Mizuki Nishibatake、Nakatsuka Takuma、Sato Masaya、Minami Tatsuya、Uchino Koji、Enooku Kenichiro、Nakagawa Hayato、Fujinaga Hidetaka、Asaoka Yoshinari、Tanaka Yasuo、Otsuka Motoyuki、Koike Kazuhiko
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 4 Pages: e0231836-e0231836
- DOI
  10.1371/journal.pone.0231836
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-18K07961
[Journal Article] Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma2019
- Author(s)
  Enooku Kenichiro、Nakagawa Hayato、Fujiwara Naoto、Kondo Mayuko、Minami Tatsuya、Hoshida Yujin、Shibahara Junji、Tateishi Ryosuke、Koike Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41598-019-47216-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02789
[Journal Article] CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity2018
- Author(s)
  Fujiwara Naoto、Nakagawa Hayato、Enooku Kenichiro、Otsuka Motoyuki、Tateishi Keisuke、Koike Kazuhiko
- Journal Title
  
  Gut
  
  Volume: 67 Issue: 8 Pages: 1493-1504
- DOI
  10.1136/gutjnl-2017-315193
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313, KAKENHI-PROJECT-16K19075, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-16K09342
[Journal Article] Lipid Metabolic Reprogramming in Hepatocellular Carcinoma.2018
- Author(s)
  Nakagawa H, Hayata Y, Kawamura S, Yamada T, Fujiwara N, Koike K.
- Journal Title
  
  Cancers
  
  Volume: 10 Issue: 11 Pages: 447-447
- DOI
  10.3390/cancers10110447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02789
[Journal Article] Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.2017
- Author(s)
  Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114(19) Issue: 19
- DOI
  10.1073/pnas.1619416114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15107, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K09038, KAKENHI-PROJECT-15K09039
[Journal Article] p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells2016
- Author(s)
  Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M
- Journal Title
  
  Cancer Cell
  
  Volume: 29 Issue: 6 Pages: 935-948
- DOI
  10.1016/j.ccell.2016.04.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313
[Journal Article] How endoplasmic reticulum stress contributes to obesity-driven hepatic tumorigenesis.2015
- Author(s)
  Nakagawa H
- Journal Title
  
  Hepat. Oncol.
  
  Volume: ２ Pages: 209-11
- Data Source
  KAKENHI-PROJECT-15K19313
[Journal Article] Impact of serum levels of interleukin-6 and adiponectin on all-cause, liver-related, and liver-unrelated mortality in chronic hepatitis C patients2015
- Author(s)
  Nakagawa H, Fujiwara N, Tateishi R, Arano T, Nakagomi R, Kondo M, Minami T, Sato M, Uchino K, Enooku K, Asaoka Y, Kondo Y, Shiina S, Yoshida H, Koike K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 30 Issue: 2 Pages: 379
- DOI
  10.1111/jgh.12719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460981, KAKENHI-PROJECT-25893042
[Journal Article] Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.2015
- Author(s)
  6.Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M.
- Journal Title
  
  Cell
  
  Volume: 162 Issue: 4 Pages: 766-79
- DOI
  10.1016/j.cell.2015.07.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19313
[Journal Article] Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis.2015
- Author(s)
  Nakagawa H
- Journal Title
  
  World J Hepatol.
  
  Volume: １８ Issue: 17 Pages: 2110-8
- DOI
  10.4254/wjh.v7.i17.2110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19313
[Journal Article] ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development2014
- Author(s)
  Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M.
- Journal Title
  
  Cancer Cell
  
  Volume: 26 Issue: 3 Pages: 331-343
- DOI
  10.1016/j.ccr.2014.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25893042
[Journal Article] Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.2014
- Author(s)
  Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 3 Pages: 1090-1095
- DOI
  10.1073/pnas.1322731111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390092, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25290045, KAKENHI-PROJECT-25670186, KAKENHI-PROJECT-25893042
[Patent] 4.脂肪性肝疾患の検出又はリスクの予測方法、脂肪性肝疾患を検出するための診断薬キット及びバイオマーカー2018
- Inventor(s)
  中川勇人
- Industrial Property Rights Holder
  中川勇人
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02789
[Patent] 3.ＮＡＦＬＤ又はＮＡＳＨの検出又はリスクの予測方法、ＮＡＦＬＤ又はＮＡＳＨを検出するための診断薬キット2018
- Inventor(s)
  中川勇人
- Industrial Property Rights Holder
  中川勇人
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02789
[Patent] ＮＡＦＬＤ又はＮＡＳＨの検出又はリスクの予測方法、ＮＡＦＬＤ又はＮＡＳＨを検出するための診断薬キット及び対象における肝線維化の進行度を判定するための診断薬キット2018
- Inventor(s)
  中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
- Industrial Property Rights Holder
  中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02789
[Patent] 脂肪性肝疾患の検出又はリスクの予測方法、脂肪性肝疾患を検出するための診断薬キット2018
- Inventor(s)
  中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
- Industrial Property Rights Holder
  中川勇人、榎奥健一郎、藤原直人、小池和彦、曲尾直樹、青木泰仁
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] 肝細胞癌における微小環境解析の最新知見2024
- Author(s)
  中川勇人
- Organizer
  第82回癌学会総会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07887
[Presentation] Unveiling the Cellular Origins and Therapeutic Targets in Extrahepatic Cholangiocarcinoma: Insights from Mouse Models and Genetic Markers.2024
- Author(s)
  Nakagawa Hayato
- Organizer
  APASL
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08000
[Presentation] AFP-expressing hepatocytes function as hepatic stem cells that give rise to liver cancer2024
- Author(s)
  Kawamura S, Tempaku M, Kimura G, Izuoka K, Tachi Y, Fujiwara N, Eguchi A, Nakagawa H
- Organizer
  アジア太平洋肝臓学会（APASL）2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07456
[Presentation] 主題：肝硬変合併症の基礎と臨床　リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] 個別化医療を見据えたNAFLD肝生検組織の網羅的transcriptome解析2023
- Author(s)
  中川勇人
- Organizer
  第59回肝臓学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] 主題：肝疾患の病態に基づいた治療戦略　慢性肝疾患に伴う骨格筋障害における肝細胞由来臓器間病態伝達体の役割2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] Molecular mechanisms and cellular origins of biliary tract cancer: cutting-edge knowledge from mouse models.2023
- Author(s)
  Nakagawa Hayato
- Organizer
  APASL Oncology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08000
[Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変ラットやヒトの骨格筋量増加に寄与する2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] AFP陽性細胞の肝再生への寄与と発癌起源としての可能性2023
- Author(s)
  川村聡、藤原直人、天白美奈、江口暁子、中川勇人
- Organizer
  第8回Gastro-PLUS
- Data Source
  KAKENHI-PROJECT-23K07456
[Presentation] 肝細胞癌における微小環境解析の最新知見2023
- Author(s)
  中川勇人
- Organizer
  第82回癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] Peribiliary glands generate biliary epithelial stem cell niche as well as origin of biliary tract cancer.2023
- Author(s)
  Nakagawa Hayato
- Organizer
  第59回肝臓学会総会 JSH-EASL Joint Session
- Invited
- Data Source
  KAKENHI-PROJECT-21K08000
[Presentation] ラジオ波焼灼術後の腫瘍検体と血漿を用いた肝癌ゲノム解析の可能性2022
- Author(s)
  中塚拓馬、中川勇人、森山慎、福本剛、山田友春、和気泰次郎、佐藤雅哉、南達也、工藤洋太郎、建石良介
- Organizer
  第1回　日本アブレーション研究会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Lipid Metabolism in NASH and NASH-related hepatocellular carcinoma.2022
- Author(s)
  中川勇人
- Organizer
  第81回癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] Genomic and molecular profiling-based personalized medicine for liver cancer.2022
- Author(s)
  Nakagawa H
- Organizer
  APASL Oncology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] Liver Cancer Research - Host Genome, Immunity and Pathology -　Summary & Prospects2022
- Author(s)
  中川勇人
- Organizer
  第58回肝臓学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] 肝癌におけるラジオ波焼灼後腫瘍生検の臨床的有用性および遺伝子変異解析の可能性2022
- Author(s)
  中塚拓馬、内野康志、中川勇人、森山慎、福本剛、山田友春、和気泰次郎、佐藤雅哉、南達也、工藤洋太郎、建石良介、藤城光弘
- Organizer
  第58回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Inhibition of SCAP/SREBP-mediated lipogenesis exacerbates liver injury and carcinogenesis in murine NASH via phospholipid metabolism disturbance.2021
- Author(s)
  Kawamura S, Nakagawa H, Koike K.
- Organizer
  American Association for the Study of Liver Diseases (AASLD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] Lipogenic pathway in NAFLD and NAFLD-related HCC: Friend or Foe?2021
- Author(s)
  Nakagawa H
- Organizer
  第57回肝臓学会総会JSH-AASLD Joint Session.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] Digital Spatial Profiling技術を用いたレンバチニブ投与後の腫瘍内免疫微小環境変化の検討.2021
- Author(s)
  山田友春、中川勇人、小池和彦
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] AXIN2+ PERIBILIARY GLAND CELLS IN PERIAMPULLARY REGION SERVE AS BILIARY EPITHELIAL STEM CELLS AND GIVE RISE TO AMPULLARY CARCINOMA.2021
- Author(s)
  Hayata Y, Nakagawa H, Koike K.
- Organizer
  Digestive Disease Week (DDW) 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08000
[Presentation] Post-treatment cell-free DNA as a predictive biomarker in systemic therapy for HCC2021
- Author(s)
  Takuma Nakatsuka, Hayato Nakagawa, Taijiro Wake, Tomoharu Yamada, Masaya Sato, Tatsuya Minami, Yotaro Kudo, Yasuo Tanaka, Motoyuki Otsuka, Ryosuke Tateishi, Kazuhiko Koike
- Organizer
  APASL Oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021
- Author(s)
  Takuma Nakatsuka, Hayato Nakagawa, Yuki Hayata, Taijiro Wake, Tomoharu Yamada, Ryo Nakagomi, Masaya Sato, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Yotaro Kudo, Yasuo Tanaka, Motoyuki Otsuka, Ryosuke Tateishi, Kazuhiko Koike
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Wnt/βカテニン経路活性化ニッチを標的とした肝発癌予防の可能性.2021
- Author(s)
  黒崎滋之、中川勇人、小池和彦.
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] Unexpected exacerbation of liver injury and carcinogenesis by inhibiting SCAP/SREBP in murine NASH.2021
- Author(s)
  中川勇人
- Organizer
  第80回癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02892
[Presentation] ケミカルバイオロジーに基づくNAFLDに対する新規治療法の創出；人工ビタミンD誘導体による脂肪肝抑制効果2020
- Author(s)
  中川勇人、小池和彦
- Organizer
  第56回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] 治療後 cell-free DNA 解析による分子標的薬の治療効果予測2020
- Author(s)
  中塚拓馬、中川勇人、早田有希、和気泰次郎、山田友春、木下瑞希、中込良、佐藤雅哉、南達也、榎奥健一郎、工藤洋太郎、田中康雄、大塚基之、建石良介、小池和彦
- Organizer
  第23回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] 治療後cell-free DNA解析による肝癌ゲノム医療に向けた試み2020
- Author(s)
  中塚拓馬、中川勇人、小池和彦
- Organizer
  第28回日本消化器関連学会週間（JDDW 2020）
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Circulating tumor DNA 解析による肝癌層別化治療に向けた試み2020
- Author(s)
  中塚拓馬、中川勇人、小池和彦
- Organizer
  第56回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Inhibition of SCAP/SREBP-mediated lipogenesis exacerbates liver injury in murine NASH model via disturbance of phospholipid metabolism.2020
- Author(s)
  Kawamura S, Nakagawa H, Koike K
- Organizer
  JDDW2020
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] 2.Clinical applications of liquid biopsy as a novel biomarker in hepatocellular carcinoma.2019
- Author(s)
  Takuma Nakatsuka, Hayato Nakagawa, Kazuhiko Koike
- Organizer
  JDDW International Session
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] NASH・肥満関連肝癌におけるlipid metabolic reprogramming2019
- Author(s)
  中川勇人、小池和彦
- Organizer
  第6回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] 4.Metabolic reprogramming in hepatocellular carcinoma for adaptation to lipid-rich environment.2019
- Author(s)
  Hayato Nakagawa
- Organizer
  JSH-EASL Joint Session
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] 3.NASH・肥満関連肝癌に特異的な脂質代謝リプログラミングに基づく病態解明とバイオマーカー探索2019
- Author(s)
  中川勇人、小池和彦
- Organizer
  第55回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] NASH病態進展における脂質生合成経路の役割2019
- Author(s)
  川村聡、中川勇人、小池和彦
- Organizer
  第27回JDDW
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] 癌種特異的脂質代謝リプログラミングを標的とした新規治療戦略2018
- Author(s)
  中川勇人、小池和彦
- Organizer
  第5回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] NAFLD患者241症例における血清アシルカルニチン精密分析2018
- Author(s)
  中川勇人、榎奥健一郎、小池和彦
- Organizer
  酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-18H02789
[Presentation] NASH・肥満関連肝癌における特異的代謝変化に着目した発癌促進機構解明2017
- Author(s)
  藤原直人、中川勇人、小池和彦
- Organizer
  第53回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-15K19313
[Presentation] 2.Obesity-driven HCC adapts to lipid-rich conditions by CPT2 downregulatin and promotes carcinogenesis through acylcarnitine accumulation.2017
- Author(s)
  Naoto Fujiwara, Hayato Nakagawa, Kenichiro Enooku, Kazuhiko Koike
- Organizer
  American Association for the Study of Liver Diseases (AASLD) anual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19313
[Presentation] Novel mouse model of NASH-driven HCC whose progression depends on TNF-IKK pathway.2016
- Author(s)
  Hayato Nakagawa, Kazuhiko Koike
- Organizer
  APASL 2016
- Place of Presentation
  東京
- Year and Date
  2016-02-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19313
[Presentation] C型慢性肝炎におけるアディポネクチン・パラドックス.2015
- Author(s)
  中川勇人、藤原直人、小池和彦
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19313
[Presentation] The vicious cycle of ER stress and steatosis in NASH progression2015
- Author(s)
  Hayato Nakagawa, Atsushi Umemura, Kazuhiko Koike, Michael Karin
- Organizer
  JDDW 2015
- Place of Presentation
  東京
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19313
[Presentation] 新規マウスモデルを用いたNASH発癌機構の解明2014
- Author(s)
  中川勇人、小池和彦
- Organizer
  肝臓と糖尿病・代謝研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-25893042
[Presentation] 新規マウスモデルを用いたNASH肝癌におけるTNFαの役割解析
- Author(s)
  中川勇人、小池和彦
- Organizer
  JDDW2013
- Place of Presentation
  グランドプリンスホテル新高輪
- Data Source
  KAKENHI-PROJECT-25893042

1. Uchino Koji (00748725)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Hayata Yuki (60897883)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 中塚拓馬 (50772042)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. 工藤洋太郎 (90608358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 藤原直人 (40971693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IKEDA Hitoshi (80202422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TOMIYA Tomoaki (90227637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Kobayashi Yuka (80724658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Nakagomi Ryo (20778039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Tateishi Ryosuke (50444089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. Yamada Tomoharu (60868024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Wake Taijiro (60895267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 木下裕人 (50645322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 田中康雄 (40422290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 岩佐元雄 (80378299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. 江口暁子 (00598980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
17. 浅岡良成 (90431858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 川村聡 (90930868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. 西川祐司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 北村浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 玉井康将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 安藝大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 畑昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 鈴木伸三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakagawa Hayato 中川 勇人

HAYATO NAKAGAWA 中川 勇人

中川 勇人 ナカガワ ハヤト

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自己免疫性肝炎とICI関連肝障害の分子学的差異に基づく病態解明とバイオマーカー開発Principal Investigator

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Unraveling the Pathophysiology of NASH through Changes in LipoQualityPrincipal Investigator

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Molecular mechanisms and translational research in NASH and obesity-related liver cancer focusing on lipid metabolic reprogramingPrincipal Investigator

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Nakagawa Hayato 中川勇人

HAYATO NAKAGAWA 中川勇人

中川勇人ナカガワハヤト

[Book] 消化器・肝臓内科胆道上皮幹細胞と乳頭部腫瘍2022