SEO HIDETAKA 瀬尾秀宗

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Seo Hidetaka 瀬尾秀宗

SEO Hidetaka 瀬尾秀宗

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Researcher Number	00561531
Other IDs
Affiliation (Current)	2026: 東京大学, 大学院総合文化研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京大学, 大学院総合文化研究科, 講師 2020 – 2021: 東京大学, 大学院総合文化研究科, 特任研究員 2015: 東京大学, 総合文化研究科, 特任研究員 2015: 東京大学, 総合文化研究科, 研究員 2014: 東京大学, 大学院総合文化研究科, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Basic Section 43050:Genome biology-related / Biomolecular chemistry
Keywords	Principal Investigator 抗体遺伝子再編成 / 相同組換え / 抗体医薬 / 抗体エンジニアリング / 条件変異株 / ジーンコンバージョン / DT40 / AID / オーキシンデグロン法 / 染色体 … More / エピジェネティクス修飾 / 抗体遺伝子 / TETファミリータンパク質 / クロマチン構造 / DNAメチル化 / 蛋白質 / バイオテクノロジー / 二重特異性抗体 / 遺伝子変換 / 抗体 Less

抗体遺伝子再編成の制御による迅速、確実な試験管内抗体創出と親和性成熟Principal Investigator
- Principal Investigator
  
  瀬尾秀宗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  The University of Tokyo
Analysis of the regulatory mechanism of immunoglobulin gene rearrangements by DNA demethyltransferasesPrincipal Investigator
- Principal Investigator
  
  Seo Hidetaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  The University of Tokyo
Development of the technology to rapidly generate bispecific antibodies.Principal Investigator
- Principal Investigator
  
  SEO Hidetaka
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022 2021 2020 2016

All Journal Article Presentation

[Journal Article] Monoclonal antibody generation by controlled immunoglobulin gene rearrangements2025
- Author(s)
  Murayama Akiho、Matsui Shin、Abe Takuya、Kanemaki Masato T.、Kurosawa Kohei、Hirota Kouji、Ohta Kunihiro、Seo Hidetaka
- Journal Title
  
  Communications Biology
  
  Volume: 8 Issue: 1 Pages: 283-283
- DOI
  10.1038/s42003-025-07690-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22H05069, KAKENHI-PLANNED-22H05072, KAKENHI-PROJECT-24K02068, KAKENHI-PROJECT-23K04503, KAKENHI-PROJECT-24KK0152
[Journal Article] Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications2024
- Author(s)
  Seo Hidetaka、Hirota Kouji、Ohta Kunihiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 1453833-1453833
- DOI
  10.3389/fimmu.2024.1453833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02068, KAKENHI-PROJECT-23K04503, KAKENHI-PROJECT-24KK0152
[Journal Article] ヒトADLibシステムによる超迅速な試験管内抗体作製と親和性成熟2023
- Author(s)
  増田瞳, 太田邦史, 瀬尾秀宗
- Journal Title
  
  科学と工業
  
  Volume: 97 Pages: 371-379
- Data Source
  KAKENHI-PROJECT-23K04503
[Journal Article] ヒトADLibシステムおよびADLib KI-AMPによる治療用抗体候補の創出と最適化2023
- Author(s)
  瀬尾秀宗, 増田瞳, 太田邦史, 橋本修一
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 855-861
- Open Access
- Data Source
  KAKENHI-PROJECT-23K04503
[Journal Article] Fast-tracking antibody maturation using a B cell-based display system2022
- Author(s)
  Masuda Hitomi、Sawada Atsushi、Hashimoto Shu-ichi、Tamai Kanako、Lin Ke-Yi、Harigai Naoto、Kurosawa Kohei、Ohta Kunihiro、Seo Hidetaka、Itou Hiroshi
- Journal Title
  
  mAbs
  
  Volume: 14 Issue: 1
- DOI
  10.1080/19420862.2022.2122275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06598
[Journal Article] TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non‐CpG sites in pseudogene templates2021
- Author(s)
  Takamura Natsuki、Seo Hidetaka、Ohta Kunihiro
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 3 Pages: 121-135
- DOI
  10.1111/gtc.12828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06598
[Journal Article] Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line.2020
- Author(s)
  Seo H, Masuda H, Asagoshi K, Uchiki T, Kawata S, Sasaki G, Yabuki T, Miyai S, Takahashi N, Hashimoto SI, Sawada A, Takaiwa A, Koyama C, Tamai K, Kurosawa K, Lin KY, Ohta K, Nakazaki Y.
- Journal Title
  
  Cell Mol Immunol.
  
  Volume: - Issue: 6 Pages: 1545-1561
- DOI
  10.1038/s41423-020-0440-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09790, KAKENHI-PROJECT-20K06598
[Presentation] 抗試験管内ヒト抗体作製技術「ヒトADLibシステム」の開発2022
- Author(s)
  瀬尾秀宗
- Organizer
  第1回日本抗体学会設立記念学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06598
[Presentation] 「試験管内ヒト抗体作製技術「ヒトADLibシステム」の開発」2021
- Author(s)
  増田瞳, 浅越健二郎, 橋本修一, 澤田篤志, 高岩亜希, 小山智加, 玉井加奈子, 黒澤恒平, 林克儀, 太田邦史, 瀬尾秀宗
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06598
[Presentation] ヒト抗体作製技術「ヒトADLibシステム」の開発と次世代抗体医薬開発への展望2020
- Author(s)
  増田瞳、浅越健二郎、橋本修一、澤田篤志、高岩亜希、小山智加、玉井加奈子、黒澤恒平、林克儀、太田邦史、瀬尾秀宗
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06598
[Presentation] Artificial evolution of variable domains of antibody genes in chicken DT40 cells2016
- Author(s)
  村山晃歩、瀬尾秀宗、太田邦史
- Organizer
  Q-Bio 2016 Winter
- Place of Presentation
  米国・ハワイ州
- Year and Date
  2016-02-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560430
[Presentation] 免疫系細胞を利用した抗体エンジニアリング技術の開発2016
- Author(s)
  橋本講司、黒澤恒平、村山晃歩、瀬尾秀宗、太田邦史
- Organizer
  第16回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学（東京都目黒区）
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-26560430

1. 黒澤恒平 (50727170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 宮井俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 太田邦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 阿部拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SEO HIDETAKA 瀬尾 秀宗

Seo Hidetaka 瀬尾 秀宗

SEO Hidetaka 瀬尾 秀宗

Research Projects

Research Products

Co-Researchers

抗体遺伝子再編成の制御による迅速、確実な試験管内抗体創出と親和性成熟Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the regulatory mechanism of immunoglobulin gene rearrangements by DNA demethyltransferasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the technology to rapidly generate bispecific antibodies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Monoclonal antibody generation by controlled immunoglobulin gene rearrangements2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ヒトADLibシステムによる超迅速な試験管内抗体作製と親和性成熟2023

Author(s)

Journal Title

Data Source

[Journal Article] ヒトADLibシステムおよびADLib KI-AMPによる治療用抗体候補の創出と最適化2023

Author(s)

Journal Title

Data Source

[Journal Article] Fast-tracking antibody maturation using a B cell-based display system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non‐CpG sites in pseudogene templates2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 抗試験管内ヒト抗体作製技術「ヒトADLibシステム」の開発2022

Author(s)

Organizer

Data Source

[Presentation] 「試験管内ヒト抗体作製技術「ヒトADLibシステム」の開発」2021

Author(s)

Organizer

Data Source

[Presentation] ヒト抗体作製技術「ヒトADLibシステム」の開発と次世代抗体医薬開発への展望2020

Author(s)

Organizer

Data Source

[Presentation] Artificial evolution of variable domains of antibody genes in chicken DT40 cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 免疫系細胞を利用した抗体エンジニアリング技術の開発2016

Author(s)

Organizer

Place of Presentation

Year and Date

SEO HIDETAKA 瀬尾秀宗

Seo Hidetaka 瀬尾秀宗

SEO Hidetaka 瀬尾秀宗