SHARIF JAFAR ＳＨＡＲＩＦＪＡＦＡＲ

… Alternative Names

SHARIF Jafar SHARIF JAFAR

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Researcher Number	00577968
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, 専任研究員 2017: 独立法人理化学研究所, 生命医科学研究センター, 研究員 2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Genome biology Except Principal Investigator Laboratory animal science
Keywords	Principal Investigator Transcription / DNA methylation / DNAメチル化 / H2Bモノユビキチン化 / エピゲノム / DNA複製タイミング / 3次元ゲノム / Retrotransposon / RNF20 / H2B monoubiquitination … More / DNA replication / A/B compartments / Heterochromatin / Euchromatin / Epigenome / 3D genome / CTCF / H2Bub / SINE / Replication timing / データ解析 / 転写解析 / 皮膚バリア機能 / 核内３次元構造 / エピジェネティクス / H3K27me3 / Differentiated cells / Basal layer / 3D genome organization / Barrier Function / Programmed cel death / 3D nuclear regulation / Stratum granulosum / Keratinocytes / Barrier function / Gene expression / 3D nuclear domain / Epigenetics / Keratinocyte / Epidermis / ChIP / ES cells / Conditional KO / H3K9 trimethylation / NP97/UHRF2 / NP95/UHRF1 / LTR-derived sequences / hemi-methylated DNA / Development / Placenta / IAP / Endogenous retroviruses / H3K9me3 / SETDB1 / Hemimethylated DNA / NP95 … More Except Principal Investigator ヒストン修飾 / リプログラミング / 配偶子形成 / 卵子形成 / 卵子 / DNAメチル化 / エピジェネティクス / 生殖細胞 / 着床前発生 / 初期発生 / 卵母細胞 / UHRF1 Less

３次元ゲノム形成の分子基盤解明及びその生物学的な意義の解析Principal Investigator
- Principal Investigator
  
  SHARIF JAFAR
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Institute of Physical and Chemical Research
A link between genome and epigenome for regulation of replication timingPrincipal Investigator
- Principal Investigator
  
  SHARIF Jafar
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Institute of Physical and Chemical Research
Role of the epigenome and 3D nuclear dynamics in maintenance of skin barrier functionPrincipal Investigator
- Principal Investigator
  
  SHARIF Jafar
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Institute of Physical and Chemical Research
Role of UHRF1 during oogenesis and early embryogenesis
- Principal Investigator
  
  UNOKI Motoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyushu University
Mechanistic link between DNA methylation and H3K9 trimethylation in mammalian cells mediated by two novel SRA proteins- Np95 and Np97Principal Investigator
- Principal Investigator
  
  SHARIF JAFAR
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Bridging multiple dimensions: roles of transposable elements in higher-order genome regulation2023
- Author(s)
  Jafar Sharif, Haruhiko Koseki, Nicholas F Parrish
- Journal Title
  
  Curr Opin Genet Dev .
  
  Volume: 80 Pages: 102035-102035
- DOI
  10.1016/j.gde.2023.102035
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06129
[Journal Article] Efficient de novo assembly and modification of large DNA fragments2022
- Author(s)
  Jiang S, Tang Y, Xiang L, Zhu X, Cai Z, Li L, Chen Y, Chen P, Feng Y, Lin X, Li G, Sharif J, Dai J
- Journal Title
  
  Sci China Life Sci.
  
  Volume: 65 (7) Issue: 7 Pages: 1445-1455
- DOI
  10.1007/s11427-021-2029-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06129
[Journal Article] PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment2022
- Author(s)
  Takano J, Ito S, Dong Y, Sharif J, Nakajima-Takagi Y, Umeyama T, Han YW, Isono K, Kondo T, Iizuka Y, Miyai T, Koseki Y, Ikegaya M, Sakihara M, Nakayama M, Ohara O, Hasegawa Y, Hashimoto K, Arner E, Klose RJ, Iwama A, Koseki H, Ikawa T
- Journal Title
  
  Nat Commun.
  
  Volume: 13 (1) Issue: 1 Pages: 7159-7159
- DOI
  10.1038/s41467-022-34856-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06129, KAKENHI-PROJECT-21K16257, KAKENHI-PROJECT-19H05653, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746
[Journal Article] Structural basis for activation of DNMT12022
- Author(s)
  Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez PA, Arita K
- Journal Title
  
  Nat Commun.
  
  Volume: 13 (1) Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-022-34779-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06129, KAKENHI-PUBLICLY-21H05733, KAKENHI-PROJECT-19H03153, KAKENHI-ORGANIZER-19H05739, KAKENHI-PUBLICLY-21H00272, KAKENHI-PROJECT-23K23828, KAKENHI-PLANNED-19H05741
[Journal Article] A unique mode of keratinocyte death requires intracellular acidification2021
- Author(s)
  Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y, Shiraga K, Sasaki H, Ishida A, Takahashi S, Okada T, Toyooka K, Sharif J, Abe T, Kiyonari H, Tominaga M, Miyawaki A, Amagai M
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 17
- DOI
  10.1073/pnas.2020722118
- Data Source
  KAKENHI-PROJECT-18K06188
[Journal Article] Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.2017
- Author(s)
  Maenohara S, Unoki M, Toh H, Ohishi H, Sharif, J, Koseki, H, Sasaki H.
- Journal Title
  
  PLoS Genet
  
  Volume: 13 Issue: 10 Pages: e1007042-e1007042
- DOI
  10.1371/journal.pgen.1007042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15K06803
[Journal Article] Activation of Endogenous Retroviruses in Dnmt1-/- ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.2016
- Author(s)
  Sharif J, Endo TA, Nakayama M, Karimi MM, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun MA, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz MC, Koseki H.
- Journal Title
  
  Cell Stem Cell
  
  Volume: Epub ahead of print Issue: 1 Pages: 999-999
- DOI
  10.1016/j.stem.2016.03.013
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870847, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-15K08280, KAKENHI-PROJECT-16K15239, KAKENHI-PROJECT-26250027
[Presentation] エピジェネティック制御因子Uhrf1の卵子及び初期胚細胞質における新機能2017
- Author(s)
  上村修平、前之原章司、小倉淳郎、井上貴美子、山縣一夫、堀真由子、Jafar Sharif、古関明彦、植田幸嗣、鵜木元香、佐々木裕之
- Organizer
  第40回日本分子生物学会年会（2017年度生命科学系学会合同年次大会）
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成および着床前発生過程のDNAメチル化制御におけるUhrf1の役割2016
- Author(s)
  前之原章司, 鵜木元香, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 佐々木裕之
- Organizer
  第39回分子生物学学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成過程および初期胚発生期のDNAメチル化制御におけるUhrf1の重要性2016
- Author(s)
  前之原章司, 鵜木元香, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 佐々木裕之
- Organizer
  第10回エピジェネティクス研究会年会
- Place of Presentation
  大阪
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] Essential role of Uhrf1 during oocyte growth and preimplantation development2016
- Author(s)
  Shoji Maenohara, Motoko Unoki, Hidehiro Toh, Hiroaki Ohishi, Jafar Sharif, Haruhiko Koseki, Hiroyuki Sasaki
- Organizer
  the 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription
- Place of Presentation
  蘇州
- Year and Date
  2016-05-09
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成過程および初期発生におけるUHRF1の役割2016
- Author(s)
  前之原章司, 鵜木元香, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 佐々木裕之
- Organizer
  第１回エピジェネティック修飾読み手分子の構造と生命機能をつなぐ会
- Place of Presentation
  福岡
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成過程および初期胚発生におけるUhrf1の重要性2015
- Author(s)
  前之原章司, 鵜木元香, 小倉淳郎, 井上貴美子, 山縣一夫, 堀真由子, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 植田幸嗣, 佐々木裕之
- Organizer
  第60回日本人類遺伝学会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成過程および初期胚発生におけるUhrf1の重要性2015
- Author(s)
  前之原章司, 鵜木元香, 小倉淳郎, 井上貴美子, 山縣　一夫, 堀真由子, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 植田幸嗣, 佐々木裕之
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成過程および初期胚発生において細胞質に存在するUhrf1の重要性2015
- Author(s)
  前之原章司, 鵜木元香, 小倉淳郎, 井上貴美子, 山縣一夫, 堀真由子, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 植田幸嗣, 佐々木裕之
- Organizer
  生殖エピゲノム若手勉強会 2015
- Place of Presentation
  ラフォーレ修善寺
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] Epigenetic regulator Uhrf1 plays a role in the oocyte cytoplasm that is essential for pre-implantation development2015
- Author(s)
  Motoko Unoki, Shoji Maenohara, Atsuo Ogura, Kimiko Inoue, Kazuo Yamagata, Hidehiro Toh, Hiroaki Ohishi, Jafar Sharif, Haruhiko Koseki, Koji Ueda, Hiroyuki Sasaki
- Organizer
  第40回内藤コンファレンス「エピジェネティクス―ヒストンコードから治療戦略へ」
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ
- Year and Date
  2015-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] 卵子形成過程および初期胚発生において細胞質に存在するUhrf1の重要性2015
- Author(s)
  前之原章司, 鵜木元香, 小倉淳郎, 井上貴美子, 山縣一夫, 堀真由子, Jafar Sharif, 古関明彦, 藤英博, 大石裕晃, 植田幸嗣, 佐々木裕之
- Organizer
  第9回エピジェネティクス研究会
- Place of Presentation
  学術総合センター一橋講堂
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15K06803
[Presentation] Protracted binding of NP95 to hemimethylated DNA disrupts SETDB1-mediated proviral silencing
- Author(s)
  Jafar Sharif
- Organizer
  Keystone Symposia (Epigenetics Z3, 2015)
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2015-03-30 – 2015-04-03
- Data Source
  KAKENHI-PROJECT-26870847

1. UNOKI Motoko (30525374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. OGURA Atsuo (20194524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. YAMAGATA Kazuo (10361312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. ARITA Kyohei (40549648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. UEDA Koji (10509110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. MAENOHARA Shoji

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. 佐々木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHARIF JAFAR ＳＨＡＲＩＦ ＪＡＦＡＲ

SHARIF Jafar SHARIF JAFAR

Research Projects

Research Products

Co-Researchers

３次元ゲノム形成の分子基盤解明及びその生物学的な意義の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A link between genome and epigenome for regulation of replication timingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the epigenome and 3D nuclear dynamics in maintenance of skin barrier functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of UHRF1 during oogenesis and early embryogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanistic link between DNA methylation and H3K9 trimethylation in mammalian cells mediated by two novel SRA proteins- Np95 and Np97Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Bridging multiple dimensions: roles of transposable elements in higher-order genome regulation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient de novo assembly and modification of large DNA fragments2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for activation of DNMT12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A unique mode of keratinocyte death requires intracellular acidification2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of Endogenous Retroviruses in Dnmt1-/- ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] エピジェネティック制御因子Uhrf1の卵子及び初期胚細胞質における新機能2017

Author(s)

Organizer

Data Source

[Presentation] 卵子形成および着床前発生過程のDNAメチル化制御におけるUhrf1の役割2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SHARIF JAFAR ＳＨＡＲＩＦＪＡＦＡＲ