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Moteki Hajime  茂木 肇

ORCIDConnect your ORCID iD *help
Researcher Number 00582272
Affiliation (Current) 2026: 城西大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2024 – 2025: 城西大学, 薬学部, 准教授
2020 – 2023: 城西大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 47040:Pharmacology-related
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related
Keywords
Principal Investigator
細胞増殖促進 / L-グルタミン酸 / 肝再生 / 細胞増殖促進機構 / 初代培養肝実質細胞 / 成長ホルモン受容体 / Janus kinase 2:JAK2 / インスリン様増殖因子1(IGF-1) / S-アリル-L-システイン(SAC) / Ras … More / ERK2 / α1アドレナリン作動性 / cyclin B1 / S-アリル-L-システイン / Janus kinase 2 (JAK2) / インスリン様増殖因子1型 (IGF-I) / 細胞増殖促進作用 / 肝実質細胞 / S-Allyl-L-cysteine (SAC) … More
Except Principal Investigator
初代培養肝実質細胞 / 肝再生モデル動物 / 甲状腺ホルモン / ERK1/2 activity / BrdU staining / liver regeneration / triiodothyronine Less
  • Research Projects

    (3 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (1 People)
  •  肝再生促進薬の開発を目指したL-グルタミン酸の肝細胞増殖促進作用機構の解明Principal Investigator

    • Principal Investigator
      茂木 肇
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Josai University
  •  生体肝移植後の肝再生現象に対する甲状腺ホルモンの作用の検討とその分子機構の解明

    • Principal Investigator
      木村 光利
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Josai University
  •  Signal transduction pathway for S-allyl-L-cysteine-induced cell proliferation in primary cultures of adult rat hepatocytes.Principal Investigator

    • Principal Investigator
      Moteki Hajime
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Josai University

All 2025 2023 2022 2021

All Journal Article Presentation

  • [Journal Article] <i>S</i>-Allyl-L-cysteine Promotes Cell Proliferation by Stimulating Growth Hormone Receptor/Janus Kinase 2/Phospholipase C Pathways and Promoting Insulin-Like Growth Factor Type-I Secretion in Primary Cultures of Adult Rat Hepatocytes2022

    • Author(s)
      Hajime Moteki, Masahiko Ogihara, Mitsutoshi Kimura
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 45 Issue: 5 Pages: 625-634

    • DOI

      10.1248/bpb.b21-01071

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2022-05-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16011
  • [Journal Article] Cell proliferation effects of S-allyl-L-cysteine are associated with phosphorylation of janus kinase 2, insulin-like growth factor type-I receptor tyrosine kinase, and extracellular signal-regulated kinase 2 in primary cultures of adult rat hepatocytes2022

    • Author(s)
      Hajime Moteki, Masahiko Ogihara, Mitsutoshi Kimura
    • Journal Title

      European Journal of Pharmacology

      Volume: 927 Pages: 175067-175067

    • DOI

      10.1016/j.ejphar.2022.175067

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16011
  • [Presentation] トリヨードチロニンの初代培養肝実質細胞に対する増殖促進作用はEGF/TGF-α RTK/PI3K/ERK経路を経由する2025

    • Author(s)
      茂木 肇、荻原 政彦、木村 光利
    • Organizer
      第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会(APPW2025)
    • Data Source
      KAKENHI-PROJECT-23K08036
  • [Presentation] ラット初代培養肝実質細胞におけるS-allyl-L-cysteine誘発ERK2リン酸化活性に対するα1アドレナリン作動薬の増強作用2023

    • Author(s)
      茂木 肇、荻原 政彦、木村 光利
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-20K16011
  • [Presentation] 成熟ラット初代培養肝実質細胞におけるS-allyl-L-cysteineのIGF-I受容体チロシンキナーゼリン酸化活性促進作用に関する検討2022

    • Author(s)
      茂木 肇、荻原 政彦、木村 光利
    • Organizer
      第95回日本薬理学会年会/第43回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16011
  • [Presentation] 初代培養感実質細胞におけるS-allyl-L-cysteineのIGF-I分泌およびその作用機構に関する検討2022

    • Author(s)
      茂木 肇、栗原 一樹、荻原 政彦、木村 光利
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K16011
  • [Presentation] S-アリルーL-システインの初代培養肝実質細胞における細胞増殖促進作用機構の検討2021

    • Author(s)
      茂木 肇
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K16011
  • 1.  木村 光利 (00255027)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results

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