Daisuke Kudo 工藤大輔

… Alternative Names

KUDO Daisuke 工藤大輔

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Researcher Number	00587024
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2022: 弘前大学, 医学研究科, 客員研究員 2016 – 2018: 弘前大学, 医学研究科, 講師 2013 – 2014: 弘前大学, 医学部附属病院, 講師 2012: 弘前大学, 医学(系)研究科(研究院), 助教 2011: 弘前大学, 医部附属病院, 助教 2010 – 2011: 弘前大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 4-メチルウンベリフェロン / 化学療法 / ヒアルロン酸 / 間質 / 膵癌 / 浸潤性膵管癌 / 膵星細胞 Except Principal Investigator 大腸癌 / 膵癌間質 / 細胞外マトリックス … More / ヒアルロン酸 / 膵癌 / ヒアルロン酸合成阻害 / ヒアルロン酸合成阻害剤 / 化学療法後肝障害 / 大腸癌肝転移 / 脂肪肝炎 / イリノテカン / 化学療法 / 腫瘍血管新生因子 / 術前化学療法 / 術前化学放射線療法 / 血管新生因子 / 低酸素誘導因子 / 膵癌間質制御 / nab-paclitaxel / gemcitabine / 膵星細胞 / 膵臓癌 / 間質制御 / 膵癌治療 / hyaluronan / extracellular matrix / pancreatic cancer / 4-Methylumbelliferone / 4メチルウンベリフェロン / 免疫担当細胞 / γδT cell / γδT細胞 / CD44 / 抗癌剤細胞内移行 / ヒアルロン酸合成抑制 / 4-methylumbelliferone / 癌幹細胞 / ４メチルウンベリフェロン / 間質 / 新規抗がん剤 / 進行再発大腸癌 / 有機アニオントランスポーター / 脂質代謝 / liver resection / noninvasive analysis / ultrasound / irinotecan / liver damage / steatohepatitis / colorectal cancer / Conversion therapy / 脂肪肝 / 化学療法後肝切除 / 肝切除 / アニオントランスポーター / 類洞拡張 / トランスポーター / 薬剤性肝障害 / 転移性肝癌 Less

Development of Pancreatic Cancer Therapy via Cancer Softening Action by Stromal InhibitionPrincipal Investigator
- Principal Investigator
  
  Daisuke Kudo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hirosaki University
Elucidation of the action mechanism of hyaluronic acid synthesis inhibitor, a novel therapeutic drug for recurrent colorectal cancer
- Principal Investigator
  
  SAKAMOTO YOSHYUKI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hirosaki University
Establishment of Pancreatic Stellate Cell Inactivation by Cell Stromal Regulation to Conquer Pancreatic Cancer
- Principal Investigator
  
  Ishido Keinosuke
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hirosaki University
Development of new treatment for advanced and recurrent colorectal cancer using hyaluronic acid synthesis inhibitor
- Principal Investigator
  
  Sakamoto Yoshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hirosaki University
Development of Novel Therapies for Pancreatic Cancer by Regulating the Cancer Microenvironment Using Hyaluronan as a Target
- Principal Investigator
  
  Hakamada Kenichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hirosaki University
Extended indication of conversion hepatectomy for initially unresectable colorectal liver metastasis
- Principal Investigator
  
  HAKAMADA Kenichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hirosaki University
Basic research on the establishment of a new multidisciplinary treatment strategy against colorectal liver metastasis
- Principal Investigator
  
  HAKAMADA Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hirosaki University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.2020
- Author(s)
  Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 1156-1156
- DOI
  10.1038/s41598-020-57883-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587, KAKENHI-PROJECT-18K16220, KAKENHI-PROJECT-19K09036
[Journal Article] Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population.2020
- Author(s)
  Kudoh K, Mizukami H, Itabashi C, Fuke N, Osonoi S, Takeuchi Y, Wada K, Igawa A, Ogasawara S, Ishibashi Y, Hakamada K, Yagihashi S, Nakaji S.
- Journal Title
  
  BMJ Open Diabetes Res Care
  
  Volume: 8 Issue: 1 Pages: e001739-e001739
- DOI
  10.1136/bmjdrc-2020-001739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.2019
- Author(s)
  Suto A, Kudo D, Yoshida E, Nagase H, Suto S, Mimura J, Itoh K, Hakamada K.
- Journal Title
  
  Pancreas.
  
  Volume: 48 Issue: 2 Pages: 292-298
- DOI
  10.1097/mpa.0000000000001211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] 4-Methylumbelliferone Decreases the Hyaluronan-rich Extracellular Matrix and Increases the Effectiveness of 5-Fluorouracil2018
- Author(s)
  Yoshida E, Kudo D, Nagase H, Suto A, Shimoda H, Suto S, Kakizaki I, Endo M, Hakamada K.
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Issue: 10 Pages: 5799-5804
- DOI
  10.21873/anticanres.12919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.2017
- Author(s)
  Saito T, Mizukami H, Umetsu S, Uchida C, Inaba W, Abe M, Takahashi K, Kudo K, Itabashi C, Yagihashi S, Hakamada K.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 18056-18067
- DOI
  10.1038/s41598-017-18438-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-16K10587
[Journal Article] The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma.2017
- Author(s)
  Kudo D, Suto A, Hakamada K.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 3 Pages: 600-600
- DOI
  10.3390/ijms18030600
- NAID
  120006576911
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] 4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.2017
- Author(s)
  Nagase H, Kudo D, Suto A, Yoshida E, Suto S, Negishi M, Kakizaki I, Hakamada K
- Journal Title
  
  Pancreas.
  
  Volume: 46 Issue: 2 Pages: 190-197
- DOI
  10.1097/mpa.0000000000000741
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] Combination therapy with gemcitabine and nab-paclitaxel for locally advanced unresectable pancreatic cancer2017
- Author(s)
  Saito Takeshi、Ishido Keinosuke、Kudo Daisuke、Kimura Norihisa、Wakiya Taiichi、Nakayama Yoshihito、Hakamada Kenichi
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 6 Issue: 6 Pages: 963-967
- DOI
  10.3892/mco.2017.1251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer.2016
- Author(s)
  Yoshida E, Kudo D, Nagase H, Shimoda H, Suto S, Negishi M, Kakizaki I, Endo M, Hakamada K.
- Journal Title
  
  Oncol Lett.
  
  Volume: 12 Pages: 2337-2344
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587
[Journal Article] Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan2015
- Author(s)
  Sawano T, Shimizu T, Yamada T, Nanashima N, Miura T, Morohashi S, Kudo D, Hui F-M, Kijima H, Hakamada K, Tsuchida S
- Journal Title
  
  Oncology Reports
  
  Volume: 33 Pages: 2151-2160
- DOI
  10.3892/or.2015.3814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500484, KAKENHI-PROJECT-24591990, KAKENHI-PROJECT-25861148
[Journal Article] Conversion therapyによる切除の実際　大腸がん肝転移巣の切除2015
- Author(s)
  豊木嘉一工藤大輔, 袴田健一
- Journal Title
  
  臨床腫瘍プラクティス
  
  Volume: 11 Pages: 45-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] Perioperative blood transfusion as a poor prognostic factor after aggressive surgical resection for hilar cholangiocarcinoma.2015
- Author(s)
  Kimura N, Toyoki Y, Ishido K, Kudo D, Yakoshi Y, Tsutsumi S, Miura T, Wakiya T, Hakamada K.
- Journal Title
  
  Journal of Gastrointestinal Surgery
  
  Volume: 19 Issue: 5 Pages: 866-79
- DOI
  10.1007/s11605-014-2741-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] Ex vivo application of endocytoscopy for determining the longitudinal extent of bile duct cancer: a pathological analysis of 28 resected cases.2015
- Author(s)
  Yoshikawa T, Hakamada K, Ogasawara H, Kimura N, Kudo D, Sakamoto Y, Ishido K, Toyoki Y, Morohashi S, Kijima H.
- Journal Title
  
  Journal of Hepato-Biliary-Pancreatic Sciences
  
  Volume: 22 Issue: 1 Pages: 58-67
- DOI
  10.1002/jhbp.167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] Evaluation of the usefulness of the indocyanine green clearance test for chemotherapy-associated liver injury in patients with colorectal cancer liver metastasis2014
- Author(s)
  Wakiya T, Kudo D, Toyoki Y, Ishido K, Kimura N, Narumi S, Kijima H, Hakamada K.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 21 Issue: 1 Pages: 167-72
- DOI
  10.1245/s10434-013-3203-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] 全身化学療法が奏効しConversionし得た切除不能膵癌の検討2014
- Author(s)
  櫻庭伸悟, 豊木嘉一, 石戸圭之輔, 工藤大輔, 木村憲央, 脇屋太一, 袴田健一
- Journal Title
  
  癌と化学療法
  
  Volume: 40 Pages: 1878-1880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] NON-INVASIVE QUANTIFICATION OF LIVER DAMAGE BY A NOVEL APPLICATION FOR STATISTICAL ANALYSIS OF ULTRASOUND SIGNALS2014
- Author(s)
  Yakoshi Y, Kudo D, Toyoki Y, Isido K, Kimura No, Wakiya T, Sakuraba S, Yoshizawa T, Sakamoto Y, Kijima H, Hakamada K
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 65 Pages: 199-208
- NAID
  110009838278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma.2013
- Author(s)
  Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M.
- Journal Title
  
  Hepatology
  
  Volume: 57 Issue: 4 Pages: 1407-1415
- DOI
  10.1002/hep.25956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590470, KAKENHI-PROJECT-23590998, KAKENHI-PROJECT-23701089, KAKENHI-PROJECT-23790820, KAKENHI-PROJECT-24590980, KAKENHI-PROJECT-24591990, KAKENHI-PROJECT-24592003
[Journal Article] 化学療法による肝障害2013
- Author(s)
  工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、村田暁彦、小山基、坂本義之、諸橋一、矢越雄太、横山拓史、吉田枝里、鬼島宏、袴田健一
- Journal Title
  
  肝胆膵
  
  Volume: 67 Pages: 581-588
- Data Source
  KAKENHI-PROJECT-24591990
[Journal Article] 大腸癌肝転移切除症例における科学療法による肝障害度の病理組織学的検討2010
- Author(s)
  工藤大輔、大橋大成、赤坂治枝、神寛之、小山基、豊木嘉一、村田暁彦、鳴海俊治、鬼島宏、袴田健一
- Journal Title
  
  消外会誌
  
  Volume: 43(1) Pages: 26-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591742
[Journal Article] 造影超音波技術の問題解決術中ソナゾイド造2010
- Author(s)
  工藤大輔、室谷隆裕、吉川徹、小笠原紘志、矢越雄太、堤伸二、三浦卓也、木村昭利、諸橋一、坂本義之、石戸圭之輔、小山基、村田暁彦、豊木嘉一、鳴海俊治、袴田健一
- Journal Title
  
  影超音波が肝切除術に与える影響INNERVISION
  
  Volume: 25(11) Pages: 78-80
- Data Source
  KAKENHI-PROJECT-21591742
[Journal Article] 大腸癌肝転移切除症例における化学療法による肝障害度の病理組織学的検討2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Journal Title
  
  日本消化器外科学会雑誌
  
  Volume: 43 Pages: 20-26
- NAID
  110007503948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591742
[Journal Article] 造影超音波技術の問題解決術中ソナゾイド造影超音波が肝切除術に与える影響2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Journal Title
  
  INTERVISION
  
  Volume: 25 Pages: 78-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591742
[Journal Article] 大腸癌肝転移切除術前に施行された化学療法による背景肝の病理組織学的肝障害度を予測する因子に関する検討2009
- Author(s)
  工藤大輔、堤伸二、赤坂治枝、神寛之、大橋大成、室谷隆裕、長谷部達也、坂本義之、石戸圭之輔、小山基、豊木嘉一、村田暁彦、鳴海俊治、鬼島宏、袴田健一
- Journal Title
  
  癌と化学療法
  
  Volume: 36 Pages: 2025-2027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] AGEs-RAGE signalを介したPSCの活性化によりIL-6の分泌能が亢進する2020
- Author(s)
  原裕太郎、水上浩哉、遅野井祥、井川明子、工藤和洋、袴田健一
- Organizer
  第18回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] Clinical Experience of Nab-paclitaxel Plus Gemcitabine Treatment in Recurrent Cases with Pancreatic Cancer in our Institution2019
- Author(s)
  Wakasa Y, Kimura N, Ishido K, Kudo D, Nagase N, Hakamada K.
- Organizer
  International Hepato-Pancreatic-Biliary Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] HISTOPATHOLOGICAL IMPACT IN PANCREATIC CANCER STROMA INDUCED BY NAB-PACLITAXEL2018
- Author(s)
  石戸圭之輔、工藤大輔、木村憲央、脇屋太一、櫻庭真悟、内田知顕、袴田健一
- Organizer
  13th IHPBA World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08695
[Presentation] 切除不能局所進行膵癌におけるConversion surgeryをゴールとした治療戦略2018
- Author(s)
  石戸圭之輔、工藤大輔、木村憲央、脇屋太一、櫻庭真悟、袴田健一
- Organizer
  第118回日本外科学会
- Data Source
  KAKENHI-PROJECT-18K08695
[Presentation] HISTOPATHOLOGICAL IMPACT IN PANCREATIC CANCER STROMA INDUCED BY NAB-PACLITAXEL2018
- Author(s)
  石戸圭之輔、工藤大輔、木村憲央、脇屋太一、袴田健一
- Organizer
  49th American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08695
[Presentation] 膵癌間質中ヒアルロン酸を標的とした新規治療2017
- Author(s)
  須藤亜希子、工藤　大輔、吉田　枝里、長瀬　勇人、三橋　佑人、脇屋　太一、木村　憲央、石戸圭之輔、袴田　健一
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] 膵癌間質中ヒアルロン酸を標的とした新規治療法の可能性2017
- Author(s)
  須藤亜希子、工藤　大輔、吉田　枝里、長瀬　勇人、三橋　佑人、脇屋　太一、木村　憲央、石戸圭之輔、袴田　健一
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] ヒアルロン酸合成抑制剤を用いた間質制御による新たな膵癌治療法開発2016
- Author(s)
  吉田　枝里、工藤　大輔、長瀬　勇人、須藤亜希子、脇屋　太一、石戸圭之輔、豊木　嘉一、袴田　健一
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府、大阪市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] A novel tactics for the treatment of pancreatic adenocarinoma by targeting extracellular matrix2016
- Author(s)
  Suto A, Kudo D, Toyoki Y, Ishido K, Wakiya T, Nagase H, Yoshida T, Hakamada K
- Organizer
  20th meeting of the International Association of Pancreatology
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Year and Date
  2016-08-04
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] ヒアルロン酸合成阻害剤4-メチルウンベリフェロンの膵癌に対する抗腫瘍効果2016
- Author(s)
  長瀬　勇人、工藤　大輔、須藤亜希子、吉田　枝里、豊木　嘉一、袴田　健一
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  あわぎんホール（徳島県、徳島市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K10587
[Presentation] 病理組織学的腫瘍壊死効果と背景肝の肝障害に基づいた肝切除タイミング2013
- Author(s)
  工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、矢越雄太、袴田健一
- Organizer
  工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、袴田健一
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 化学療法による腫瘍壊死と背景肝の肝障害に基づいた大腸癌肝転移に対する肝切除のベストタイミング2013
- Author(s)
  工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、袴田健一
- Organizer
  第25回日本肝胆膵外科学会学術集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 当科における大腸癌肝転移に対する集学的治療2013
- Author(s)
  諸橋一、室谷隆裕、高橋誠司、木村憲央、坂本義之、工藤大輔、石戸圭之輔、小山基、豊木嘉一、村田暁彦、袴田健一
- Organizer
  第11回日本消化器外科学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 肝悪性腫瘍切除症例におけるEOB-MRIの診断能に関する検討2013
- Author(s)
  矢越雄太、工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、松村知徳、袴田健一
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移切除症例における化学療法による肝障害度とICG検査との相関について2013
- Author(s)
  脇屋太一、工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、矢越雄太、鳴海俊治、鬼島宏、袴田健一
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移に対する肝切除前全身化学療法が背景肝に与える影響2013
- Author(s)
  工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、袴田健一
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移に対する全身化学療法の病理組織学的効果判定に基づいた肝切除のベストタイミング2013
- Author(s)
  工藤大輔、豊木嘉一、石戸圭之輔、木村憲央、脇屋太一、袴田健一
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移に対する術中ソナゾイド造影超音波の有用性2012
- Author(s)
  工藤　大輔、豊木　嘉一、石戸圭之輔、袴田　健一、他
- Organizer
  第112回日本外科学会定期学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移に対する肝切除前全身化学療法の影響2012
- Author(s)
  工藤　大輔、豊木　嘉一、石戸圭之輔、袴田　健一、他
- Organizer
  第24回日本肝胆膵外科学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 肝切除前全身化学療法の効果と肝障害をもとにした至適タイミングの検討2012
- Author(s)
  工藤　大輔、豊木　嘉一、石戸圭之輔、袴田　健一、他
- Organizer
  第67回日本消化器外科学会総会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] Influence of liver injury induced by chemotherapy and liver regeneration after hepatectomy for colorectal liver metastases2012
- Author(s)
  Daisuke Kudo, Yoshikazu Toyoki, Keinosuke Ishido, Kenichi Hakamada, et al.
- Organizer
  22nd World Congress of the International Association of Surgeons, Gastroenterologists, and Oncologists
- Place of Presentation
  Bangkok（タイ）
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移切除術後の残肝肥大と背景肝の病理組織学的肝障害に関する検討2011
- Author(s)
  工藤大輔、木村憲央、坂本義之、石戸圭之輔、小山基、豊木嘉一、村田暁彦、鳴海俊治、鬼島宏、袴田健一
- Organizer
  第66回日本消化器外科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術中ソナゾイド造影超音波をもちいた大腸癌肝転移切除2011
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京(紙上発表)
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 大腸癌肝転移切除術後の残肝肥大と背景肝の病理組織学的肝障害に関する検討2011
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第66回日本消化器外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術中ソナゾイド造影超音波をもちいた大腸癌肝転移切除2011
- Author(s)
  工藤大輔、石戸圭之輔、豊木嘉一、鳴海俊治、袴田健一
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  震災のため紙上発表
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] Impact of perflubutane microbuble (Sonazoid)-enhanced intraoperative ultrasound on the surgical management of colorectal liver metastases2011
- Author(s)
  Kudo D, Hakamada K, et al.
- Organizer
  21th World Congress of the International Association of Surgeons, Gastroenterologists, and Oncologists
- Place of Presentation
  東京
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 化学療法による背景肝の肝障害と手術のベストタイミングに関する検討2011
- Author(s)
  工藤大輔、堤伸二、大橋大成、石戸圭之輔、豊木嘉一、鳴海俊治、袴田健一
- Organizer
  第23回日本肝胆膵外科学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] Hakamada K Impact of perflubutane micobubble (Sonazoid)-enhanced intraoperative ultrasound on the surgical management of colorectal liver metastases2011
- Author(s)
  Kudo D, Toyoki Y, Ishido K, Kimura N, Narumi S
- Organizer
  21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2011)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] A pathological study of chemotherapy associated liver injury in colorectal liver metastases2010
- Author(s)
  Kudo D, Hakamada K
- Organizer
  DDW2010
- Place of Presentation
  Ernest N.Morial Convention Center(New Orleans)
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 肝手術計画におけるボリュームレンダリング画像の有用性2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第22回日本肝胆膵外科学会定期学術集会
- Place of Presentation
  仙台国際センター(仙台市)
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 大腸癌肝転移に対する術前全身化学療法による肝障害と脾容積に関する検討2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第64回手術手技研究会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 大腸癌化学療法による背景肝の肝障害と脾容積に関する検討2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第46回日本肝癌研究会
- Place of Presentation
  大阪国際センター(大阪市)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] シンポジウム「転移・再発消化器癌に対する新しい治療戦略」大腸癌化学療法による背景肝の肝障害を予測する因子に関する研究2010
- Author(s)
  工藤大輔、小笠原紘志、堤伸二、赤坂治枝、大橋大成、三浦卓也、諸橋聡子、諸橋一、坂本義之、石戸圭之輔、小山基、豊木嘉一、村田暁彦、鳴海俊治、鬼島宏、袴田健一
- Organizer
  第18回日本消化器関連学会週間(JDDW2010)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 大腸癌肝転移切除例における背景肝の病理組織学的肝障害と脾腫に関する検討2010
- Author(s)
  工藤大輔、諸橋聡子、小笠原紘志、堤伸二、赤坂治枝、神寛之、室谷隆裕、坂本義之、石戸圭之輔、小山基、豊木嘉一、村田暁彦、鳴海俊治、吉原秀一、鬼島宏、袴田健一
- Organizer
  第22回日本肝胆膵外科学会定期学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] シンポジウム「転移・再発消化器癌に対する新しい治療戦略」大腸癌化学療法による背景肝の肝障害を予測する因子に関する研究2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第8回日本消化器関連学会週間(JDDW2010)
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術前化学療法による肝障害の検討2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第73回大腸癌研究会
- Place of Presentation
  奄美文化センター(鹿児島市)
- Year and Date
  2010-07-02
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術前化学療法が行われた大腸癌肝転移症例における背景肝の肝障害と脾容積との関係に関する検討2010
- Author(s)
  工藤大輔、袴田健一, ほか
- Organizer
  第65回日本消化器外科学会定期学術集会
- Place of Presentation
  下関市民会館(下関市)
- Year and Date
  2010-07-14
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術前化学療法が行われた大腸癌肝転移症例における背景肝の肝障害と脾容積との関係に関する検討2010
- Author(s)
  工藤大輔、諸橋聡子、小笠原紘志、堤伸二、赤坂治枝、神寛之、室谷隆裕、大橋大成、坂本義之、石戸圭之輔、小山基、豊木嘉一、村田暁彦、鳴海俊治、吉原秀一、鬼島宏、袴田健一
- Organizer
  第65回日本消化器外科学会定期学術総会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 当科における転移性肝癌治療の考え方とその戦略2009
- Author(s)
  豊木嘉一、石戸圭之輔、工藤大輔、三浦卓也、堤伸二、鳴海俊治、袴田健一
- Organizer
  第22回日本肝胆膵外科学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術前の化学療法が大腸癌肝転移切除術におよぼす影響2009
- Author(s)
  工藤大輔、加藤雅志、大橋大成、神寛之、赤坂治枝、小山基、村田暁彦、豊木嘉一、鳴海俊治、袴田健一
- Organizer
  第64回日本消化器外科学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 術前に施行された化学療法が大腸癌肝転移切除術におよぼす臨床的・病理組織学的影響2009
- Author(s)
  工藤大輔、池永照史郎一期、加藤雅志、坂本義之、堤伸二、山名大輔、赤坂治枝、神寛之、大橋大成、小山基、豊木嘉一、鳴海俊治、袴田健一
- Organizer
  第21回日本肝胆膵外科学会・学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] 転移性肝癌の術前診断においてprimovist MRIは有用か2009
- Author(s)
  三浦卓也、久保寛仁、工藤大輔、石戸圭之輔、奈良昌樹、豊木嘉一、鳴海俊治、袴田健一
- Organizer
  第21回日本肝胆膵外科学会・学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21591742
[Presentation] Acoustic Structure Quantification(ASQ)法を用いた脂肪肝の非侵襲的定量評価
- Author(s)
  矢越雄太, 工藤大輔, 豊木嘉一, 石戸圭之輔, 木村憲央, 三浦卓也, 中山義人, 袴田健一
- Organizer
  第69回日本消化器外科学会総会
- Place of Presentation
  郡山市
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] CPT-11によるSDラット肝のsteatosis 誘発とそれに先行するKupffer 細胞の減少：CPT-11肝障害の動物モデル
- Author(s)
  澤野　武行、三浦　卓也、工藤　大輔、清水　武文、七島直紀、山田　俊幸、土田　成紀、袴田　健一
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 脂肪肝の定量的評価における Acoustic Structure Quantification (ASQ) 法の有用性
- Author(s)
  矢越　雄太、工藤　大輔、豊木　嘉一、石戸　圭之輔、坂本　義之、木村　憲央、脇屋　太一、櫻庭　伸悟、吉澤　忠司、鬼島　宏、袴田　健一
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 大腸癌肝転移に対する全身化学療法後肝切除の短期的・長期的成績に関する検討‐切除可能肝転移に化学療法は必要なのか‐
- Author(s)
  工藤　大輔、諸橋　一、豊木　嘉一、小山　基、石戸　圭之輔、坂本　義之、木村　憲央、三浦　卓也、脇屋　太一、矢越　雄太、一戸　大地、袴田　健一
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] R1 切除となった大腸癌肝転移切除例の検討
- Author(s)
  三浦　卓也、諸橋　一、坂本　義之、小山　基、村田　暁彦、脇屋　太一、木村　憲央、工藤　大輔、石戸　圭之輔、豊木　嘉一、袴田　健一
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-24591990
[Presentation] 切除可能大腸癌肝転移症例に対する全身化学療法は予後に寄与せず、特に有効例ほど肝障害発生が高まる
- Author(s)
  工藤大輔, 豊木嘉一, 石戸圭之輔, 木村憲央, 三浦卓也, 脇屋太一, 袴田健一
- Organizer
  第69回日本消化器外科学会総会
- Place of Presentation
  郡山市
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24591990

1. HAKAMADA Kenichi (30271802)

# of Collaborated Projects: 7 results

# of Collaborated Products: 67 results
2. ISHIDO Keinosuke (00436023)

# of Collaborated Projects: 5 results

# of Collaborated Products: 41 results
3. 三浦卓也 (30722136)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 木村憲央 (60436029)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. Sakamoto Yoshiyuki (60361010)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TOYOKI Yoshikazu (70301025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 37 results
7. 諸橋一 (30598628)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 脇屋太一 (50571246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. NARUMI Shunji (90250612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
10. 柿崎育子 (80302024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 長瀬勇人 (10750862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉田枝里 (20648886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Mizukami Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 八木橋操六

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 土田成紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 山田俊幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 安居幸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Daisuke Kudo 工藤 大輔

KUDO Daisuke 工藤 大輔

Research Projects

Research Products

Co-Researchers

Development of Pancreatic Cancer Therapy via Cancer Softening Action by Stromal InhibitionPrincipal Investigator

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Elucidation of the action mechanism of hyaluronic acid synthesis inhibitor, a novel therapeutic drug for recurrent colorectal cancer

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Establishment of Pancreatic Stellate Cell Inactivation by Cell Stromal Regulation to Conquer Pancreatic Cancer

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Development of new treatment for advanced and recurrent colorectal cancer using hyaluronic acid synthesis inhibitor

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Development of Novel Therapies for Pancreatic Cancer by Regulating the Cancer Microenvironment Using Hyaluronan as a Target

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Extended indication of conversion hepatectomy for initially unresectable colorectal liver metastasis

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Basic research on the establishment of a new multidisciplinary treatment strategy against colorectal liver metastasis

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[Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.2020

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[Journal Article] Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population.2020

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[Journal Article] Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.2019

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[Journal Article] 4-Methylumbelliferone Decreases the Hyaluronan-rich Extracellular Matrix and Increases the Effectiveness of 5-Fluorouracil2018

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[Journal Article] Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.2017

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[Journal Article] The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma.2017

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NAID

Data Source

[Journal Article] 4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.2017

Author(s)

Daisuke Kudo 工藤大輔

KUDO Daisuke 工藤大輔

[Journal Article] Conversion therapyによる切除の実際　大腸がん肝転移巣の切除2015