FUJIMORI Hiroaki 藤森浩彰

Researcher Number	00590043
Affiliation (based on the past Project Information) *help	2015 – 2017: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2014: 国立がん研究センター研究所, 創薬臨床研究分野, 研究員 2013 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Tumor therapeutics / Molecular biology Except Principal Investigator Tumor therapeutics / Clinical oncology
Keywords	Principal Investigator PARP / PARP阻害剤 / DNAメチル化 / Dnmt3 Except Principal Investigator DNMT3b / cancer / gamma-irradiation / PARP / gamma H2AX / HP1beta … More / DNMT3B / 陽子線 / PARP阻害剤 / ガンマ線 / 放射線増感 / 網羅的探索 / 放射線感受性 / radiosensitization / epigenetic / 合成致死 / アルキル化剤 / 放射線 / gamma irradiation / knockdown / PARP1 / NAD / PARG Less

PARP阻害剤の新しい合成致死性標的の確立：BRCA・相同末端修復の枠を超えてPrincipal Investigator
- Principal Investigator
  
  藤森浩彰
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  National Cancer Center Japan
A comprehensive genome-wide screen of radiosensitization targets
- Principal Investigator
  
  MASUTANI Mitsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagasaki University
PARP inhibition induced DNA demethylation through downregulation of Dnmt3.Principal Investigator
- Principal Investigator
  
  HIROAKI Fujimori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  National Cancer Center Japan
Research for poly(ADP-ribosylation) as a potential cancer therapeutic target
- Principal Investigator
  
  MASUTANI MITSUKO
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  National Cancer Center Japan

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] PARP Inhibitors for Cancer Therapy Cancer Drug Discovery and Development2015
- Author(s)
  Junhui Wang, Akira Sato, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
- Publisher
  Springer, New York
- Data Source
  KAKENHI-PROJECT-22300343
[Journal Article] Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells.2016
- Author(s)
  Hirai T, Saito S, Fujimori H, Matsushita K, Nishio T, Okayasu R, Masutani M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 478 Issue: 1 Pages: 234-240
- DOI
  10.1016/j.bbrc.2016.07.062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14416
[Journal Article] A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.2015
- Author(s)
  Fujimori H, Sato A, Kikuhara S, Junhui W, Hirai T, Sasaki Y, Murakami Y, Okayasu R, Masutani M.
- Journal Title
  
  Sci Rep.
  
  Volume: on-line paper Issue: 1 Pages: 18231-18231
- DOI
  10.1038/srep18231
- NAID
  120006987240
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06890, KAKENHI-PROJECT-26460310, KAKENHI-PROJECT-15K14416, KAKENHI-PROJECT-24249067
[Journal Article] Poly(ADP-ribosylation) in carcinogenesis.2013
- Author(s)
  Masutani M, Fujimori H.
- Journal Title
  
  Molecular Aspects of Medicine
  
  Volume: 34 Issue: 6 Pages: 1202-1216
- DOI
  10.1016/j.mam.2013.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300343
[Journal Article] The H19 induction triggers trophoblast lineage commitment in mouse ES cells.2013
- Author(s)
  Fujimori H, Mukai H, Murakami Y, Hemberger M, Hippo Y, Masutani M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 436 Issue: 2 Pages: 313-318
- DOI
  10.1016/j.bbrc.2013.05.100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300343
[Journal Article] The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013
- Author(s)
  Yuko Atsumi, Aki lnase, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagami, Mitsuko Masutani, Ken-ichi Yoshioka
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288巻 Issue: 19 Pages: 13269-13277
- DOI
  10.1074/jbc.m112.402560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10618, KAKENHI-PROJECT-22300343, KAKENHI-PROJECT-23501271, KAKENHI-PROJECT-23616003, KAKENHI-PROJECT-25860245
[Journal Article] Parg Deficiency Confers Radio-sensitization through Enhanced Cell Death in Mouse ES Cells Exposed to Various Forms of Ionizing Radiation.2013
- Author(s)
  Shirai H, Fujimori H, Gunji A, Maeda D, Hirai T, Poetsch AR, Harada H, Yoshida T, Sasai K, Okayasu R, Masutani M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: Epub ahead of print Issue: 1 Pages: 100-106
- DOI
  10.1016/j.bbrc.2013.04.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300343, KAKENHI-PROJECT-24249067, KAKENHI-PROJECT-24890233
[Presentation] 放射線増感標的としてのIL27RA2017
- Author(s)
  小野寺貴恵, 菊原颯太, 藤森浩彰, 佐々木由香, 今道祥二, 村上康文, 益谷美都子
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K14416
[Presentation] APOBEC3Gの発現抑制による放射線増感検証と作用機序の解析2017
- Author(s)
  小野寺貴恵, 菊原颯太, 藤森浩彰, 佐々木由香, 今道祥二, 村上康文, 益谷美都子
- Organizer
  生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15K14416
[Presentation] A comprehensive analysis of radiosensitization targets2016
- Author(s)
  藤森浩彰
- Organizer
  第5回浜名湖DNA損傷ワークショップ
- Place of Presentation
  浜名湖弁天リゾート　ジ　オーシャン
- Year and Date
  2016-04-04
- Data Source
  KAKENHI-PROJECT-15K06890
[Presentation] IL27RAの機能阻害による放射線感受性の増感作用.2016
- Author(s)
  小野寺貴恵, 菊原颯太, 藤森浩彰, 佐々木由香, 今道祥二, 村上康文, 益谷美都子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K14416
[Presentation] PARP-1は、Dnmt3 promoterの制御因子として機能する2014
- Author(s)
  藤森浩彰、向井大晃、平井崇久、原田博美、工藤祐子、村上康文、渡邉昌俊、益谷美都子
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] 創薬の基盤としてのADP-リボシル化の生化学2014
- Author(s)
  益谷美都子、藤森浩彰、原田博美、光畑元晴、高村　岳樹
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] Poly(ADP-ribose) polymerase-1 maintains gene silencing through regulation of DNA methyltransferases.2013
- Author(s)
  Hiroaki Fujimori,Hiroaki Mukai, Yasufumi Murakami, MitsukoMasutani
- Organizer
  日本分子生物学会
- Place of Presentation
  ポートピアホテル(兵庫県神戸市)
- Data Source
  KAKENHI-PROJECT-25840015
[Presentation] Poly(ADP-ribose) formation/metabolism after DNA damage (DNA 損傷後のpoly(ADP-ribose)の動態の検討2013
- Author(s)
  Hiromi Harada, Miyuki Hozumi, Hiroaki Fujimori, Takahisa Hirai, Soichiro Saito, Yasufumi Murakami, Mitsuko Masutani
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川県　横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] Biological radiosensitization by PARP inhibitors2013
- Author(s)
  Mitsuko Masutani, Takahisa Hirai, Hiroaki Fujimori, Souichiro Saito, Teiji Nishio, Ryuichi Okayasu, Akira Fujimori, Keisuke Sasai
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県　横浜市　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] Parp-1 has a novel role as Dnmt3 regulator and PARP inhibitor acts as a epigenetic drug recovering silenced expression of tumor-suppressor genes.2013
- Author(s)
  Hiroaki Fujimori, Hideki Ogino, Hiroaki Mukai, Yasufumi Murakami, Mitsuko Masutani
- Organizer
  PARP2013
- Place of Presentation
  CHLU research Center (Canada, Quebec city)
- Data Source
  KAKENHI-PROJECT-25840015
[Presentation] PARP-1はDNMT3の発現を維持する新規調節因子である。2013
- Author(s)
  藤森浩彰、向井大晃、益谷美都子
- Organizer
  発がん病理研究会
- Place of Presentation
  ユインチホテル南城（沖縄県那覇市）
- Data Source
  KAKENHI-PROJECT-25840015
[Presentation] PARP-1 suppresses the end-resection of 5’- and 3’-blocked termini of double-strand DNA breaks by CtIP2013
- Author(s)
  Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県　横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] PARG機能阻害によるがん細胞株におけるアルキル化剤に対する致死感受性亢進2012
- Author(s)
  藤森浩彰、向井大晃、村上康文、益谷美都子
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] PARG機能阻害によるがん細胞株におけるアルキル化剤に対する致死感受性亢進2012
- Author(s)
  白井秀徳藤森浩彰岡島泰久益谷美都子
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] PARP-1 and PARG are both required for the regulation of 53BP1 after IR
- Author(s)
  Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-22300343
[Presentation] PARP is required for Dnmt3 transcription and protects ES cells and cancer cells from transcriptional activation of silenced genes.
- Author(s)
  Hiroaki Fujimori
- Organizer
  2014年度がん若手ワークショップ
- Place of Presentation
  蓼科グランドホテル滝の湯
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25840015
[Presentation] Parp-1 has a novel role as Dnmt3 regulator.
- Author(s)
  Hiroaki Fujimori
- Organizer
  The PARP Family & Friends
- Place of Presentation
  Cold Spring Harbor, USA
- Year and Date
  2014-04-09 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-25840015

1. MASUTANI MITSUKO (60238904)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. OKAYASU Ryuichi (50356135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. ONODERA Takae

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. SASAKI Yuka

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. HIRAI Takahisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. IMAMICHI Shoji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. KIKUHARA Sota

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

FUJIMORI Hiroaki 藤森 浩彰

Research Projects

Research Products

Co-Researchers

PARP阻害剤の 新しい合成致死性標的の確立：BRCA・相同末端修復の枠を超えてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A comprehensive genome-wide screen of radiosensitization targets

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PARP inhibition induced DNA demethylation through downregulation of Dnmt3.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for poly(ADP-ribosylation) as a potential cancer therapeutic target

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] PARP Inhibitors for Cancer Therapy Cancer Drug Discovery and Development2015

Author(s)

Publisher

Data Source

[Journal Article] Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Poly(ADP-ribosylation) in carcinogenesis.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The H19 induction triggers trophoblast lineage commitment in mouse ES cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parg Deficiency Confers Radio-sensitization through Enhanced Cell Death in Mouse ES Cells Exposed to Various Forms of Ionizing Radiation.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 放射線増感標的としてのIL27RA2017

Author(s)

Organizer

Data Source

[Presentation] APOBEC3Gの発現抑制による放射線増感検証と作用機序の解析2017

Author(s)

Organizer

Data Source

[Presentation] A comprehensive analysis of radiosensitization targets2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] IL27RAの機能阻害による放射線感受性の増感作用.2016

Author(s)

Organizer

FUJIMORI Hiroaki 藤森浩彰

PARP阻害剤の新しい合成致死性標的の確立：BRCA・相同末端修復の枠を超えてPrincipal Investigator