Higuchi Yuichiro 樋口裕一郎

… Alternative Names

Yuichiro Higuchi 樋口裕一郎

HIGUCHI Yuichiro 樋口裕一郎

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Researcher Number	00596281
Other IDs
Affiliation (Current)	2025: 公益財団法人実中研, ヒト化モデル研究部, 室長 2025: 公益財団法人実中研, 細胞資源センター, 副センター長
Affiliation (based on the past Project Information) *help	2016 – 2018: 公益財団法人実験動物中央研究所, 実験動物研究部, 研究員 2012 – 2014: 公益財団法人実験動物中央研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Laboratory animal science / Laboratory animal science Except Principal Investigator Laboratory animal science
Keywords	Principal Investigator 肝臓 / ヒト化肝臓マウス / 多能性幹細胞 / in vivo分化誘導 / 胚盤補完法 / 胚盤胞補完 / 肝臓形成不全 / TK-NOGマウス / Ｅｘ　ｕｔｅｒｏ法 / 胎仔肝 … More / Afp-TKマウス / Ex-utero法 / 肝芽細胞 / ヒト肝蔵マウス / HepaRG細胞 / 胆管上皮細胞 / ヒトiPS細胞 … More Except Principal Investigator PDX-1 / Pｄｘ１ / 糖尿病 / Pdx1 / ヒト化肝臓マウス / アデノ随伴ウィルス Less

Establishment of an in vivo differentiation system for liver cells using a fetal liver-deficient mouse modelPrincipal Investigator
- Principal Investigator
  
  Yuichiro Higuchi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Establish of novel gene therapy of diabetes using Humanized liver mice
- Principal Investigator
  
  HARUO Hashimoto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Generation of the humanized-liver mouse from human iPS cell-derived cholangiocytesPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Yichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals

All 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] スンクスの嘔吐を強化する遺伝的要因は雄に存在する可能性.2015
- Author(s)
  江袋　進、橋本晴夫、冨澤政史、何　裕遥、小倉智幸、樋口裕一郎、桑畑　玲、寺
- Journal Title
  
  実験動物技術
  
  Volume: 50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500500
[Journal Article] Forced expression of PDX-1 gene makes hepatoma cells to acquire glucose-responsive insulin secretion while maintaining hepatic characteristic.2015
- Author(s)
  Haruo HASHIMOTO, Yuichiro HIGUCHI, Kenji KAWAI.
- Journal Title
  
  Cellular & Molecular Biology
  
  Volume: 61 Pages: 21-29
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500500
[Journal Article] A Novel Enhanced Green FluorescentProtein-Expressing NOG Mouse for Analyzingthe Microenvironment of Xenograft Tissues2014
- Author(s)
  Yuichiro Higuchi, Kenji Kawai, Masafumi Yamamoto, Miyuki Kuronuma, Yasuhiko Ando, Ikumi Katano, Masato Nakamura, Hiroshi Suemizu
- Journal Title
  
  Exp. Anim.
  
  Volume: 63 Issue: 1 Pages: 55-62
- DOI
  10.1538/expanim.63.55
- NAID
  130003391611
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24700439, KAKENHI-PROJECT-25640055
[Journal Article] The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice2014
- Author(s)
  Higuchi, Y., Kawai, K., Yamazaki, H., Nakamura, M., Bree, F., Guillouzo, C., and Suemizu, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 27 Issue: 2 Pages: 146-157
- DOI
  10.3109/00498254.2013.836257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24700439
[Journal Article] A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes.2013
- Author(s)
  1. Hiroshi SUEMIZU, Kenji KAWAI, Yuichiro HIGUCHI, Haruo HASHIMOTO et al.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500500
[Presentation] DIFFERENTIATION OF BI-POTENT HEPATOBLASTS INTO HEPATOCYTES AND CHOLANGIOCYTES IN THE HEPATOBLAST-DEPLETED FETAL LIVER OF AN AFP-HSVTK TRANSGENIC MOUSE2018
- Author(s)
  Yuichiro Higuchi
- Organizer
  ISSCR 2018 Annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18403
[Presentation] Dual reconstitution model of the liver and hematopoietic system using mouse fetal liver cells2017
- Author(s)
  Yuichiro Higuchi
- Organizer
  ISSCR 2017 Annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18403
[Presentation] HepaRP3細胞によるヒト化肝臓マウスの作製2016
- Author(s)
  樋口裕一郎
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  ミューザ川崎
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K18403
[Presentation] HepaRG細胞を用いたヒト化肝臓マウスの作成2014
- Author(s)
  樋口裕一郎、川井健司、山崎洋志、中村雅登、Franxoise Bree, Christiane Guguen-Guillouzo、末水洋志
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24700439
[Presentation] HepaRG細胞を用いたヒト化肝臓マウスの作成2014
- Author(s)
  樋口裕一郎、川井健司、山崎洋志、中村雅登、Francoise Bree、Christiane Guguen-Guilllouzo、末水洋志
- Organizer
  第１３回日本再生医療学会総会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24700439

1. HARUO Hashimoto (30353478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 山崎浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higuchi Yuichiro 樋口 裕一郎

Yuichiro Higuchi 樋口 裕一郎

HIGUCHI Yuichiro 樋口 裕一郎

Research Projects

Research Products

Co-Researchers

Establishment of an in vivo differentiation system for liver cells using a fetal liver-deficient mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establish of novel gene therapy of diabetes using Humanized liver mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of the humanized-liver mouse from human iPS cell-derived cholangiocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] スンクスの嘔吐を強化する遺伝的要因は雄に存在する可能性.2015

Author(s)

Journal Title

Data Source

[Journal Article] Forced expression of PDX-1 gene makes hepatoma cells to acquire glucose-responsive insulin secretion while maintaining hepatic characteristic.2015

Author(s)

Journal Title

Data Source

[Journal Article] A Novel Enhanced Green FluorescentProtein-Expressing NOG Mouse for Analyzingthe Microenvironment of Xenograft Tissues2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes.2013

Author(s)

Journal Title

Data Source

[Presentation] DIFFERENTIATION OF BI-POTENT HEPATOBLASTS INTO HEPATOCYTES AND CHOLANGIOCYTES IN THE HEPATOBLAST-DEPLETED FETAL LIVER OF AN AFP-HSVTK TRANSGENIC MOUSE2018

Author(s)

Organizer

Data Source

[Presentation] Dual reconstitution model of the liver and hematopoietic system using mouse fetal liver cells2017

Author(s)

Organizer

Data Source

[Presentation] HepaRP3細胞によるヒト化肝臓マウスの作製2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] HepaRG細胞を用いたヒト化肝臓マウスの作成2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] HepaRG細胞を用いたヒト化肝臓マウスの作成2014

Author(s)

Organizer

Place of Presentation

Data Source

Higuchi Yuichiro 樋口裕一郎

Yuichiro Higuchi 樋口裕一郎

HIGUCHI Yuichiro 樋口裕一郎