TAKADA Toru 高田徹

Researcher Number	00598526
Affiliation (based on the past Project Information) *help	2016 – 2018: 神戸大学, 医学研究科, 医学研究員 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 医学研究員
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Medical systems
Keywords	Principal Investigator なし / マクロファージ / 椎間板 / 変性 / 神経障害性疼痛 / 侵害受容性疼痛 / 椎間板変性 Except Principal Investigator RNA干渉 / Raptor / mTOR経路 … More / 免疫特権 / オートファジー / 椎間板ヘルニア / 腰部脊柱管狭窄症 / 棘突起間スペーサー / 低侵襲脊椎手術 / 低侵襲手術システム / 固定術 / 椎間板 / 脊椎疾患 / 低侵襲治療 / 動物モデル / 腰部脊柱管狭窄 / 遺伝子治療 / 腰痛 / 椎間板変性 Less

Elucidation of pathogenesis of low back pain related to degeneration of intervertebral disc and development of minimally invasive treatment system
- Principal Investigator
  
  Nishida Kotaro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
The pathomechanism of nociceptive pain and neuropathic pain in herniated disc diseasePrincipal Investigator
- Principal Investigator
  
  TAKADA Toru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University

All 2019 2018 2017 2016 2014 2013 Other

All Journal Article Presentation

[Journal Article] Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.2019
- Author(s)
  Kakiuchi Y, Yurube T, Kakutani K, Takada T, Ito M, Takeoka Y, Kanda Y, Miyazaki S, Kuroda R, Nishida K.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: Epubahead of print Issue: 6 Pages: 1-19
- DOI
  10.1016/j.joca.2019.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03033
[Journal Article] オートファジーと椎間板変性2018
- Author(s)
  由留部　崇、伊藤雅明、角谷賢一郎、高田　徹、黒田良祐、西田康太郎
- Journal Title
  
  別冊　BIO Clinica
  
  Volume: 7 Pages: 20-23
- Data Source
  KAKENHI-PROJECT-15H03033
[Journal Article] Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Miyazaki S, Kuroda R, Nishida K.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: 25 Issue: 12 Pages: 2134-2146
- DOI
  10.1016/j.joca.2017.08.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03033, KAKENHI-PROJECT-15K10406, KAKENHI-PROJECT-16K20051
[Journal Article] A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype.2014
- Author(s)
  Hirata H, Yurube T, Kakutani K, Maeno K, Takada T, Yamamoto J, Kurakawa T, Akisue T, Kuroda R, Kurosaka M, Nishida K.
- Journal Title
  
  J Orthop Res
  
  Volume: 32 Issue: 3 Pages: 455-63
- DOI
  10.1002/jor.22533
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592195, KAKENHI-PROJECT-24592196
[Presentation] Autophagy plays protective roles against human disc cellular apoptosis, senescence, and extracellular matrix degradation2018
- Author(s)
  Masaaki Ito+, Takashi Yurube*, Kenichiro Kakutani*, Toru Takada, Yuji Kakiuchi+, Yoshiki Takeoka+, Yutaro Kanda+, Ryosuke Kuroda*, Kotaro Nishida*
- Organizer
  International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板動的圧迫負荷が脊索由来髄核細胞に及ぼした影響2018
- Author(s)
  神田祐太郎、角谷賢一朗、森田有亮、由留部　崇、伊藤雅明、垣内裕司、武岡由樹、蔵川拓外、寺島良樹、高田　徹、黒田良祐、西田康太郎
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor to protect human disc cells depending on Akt and autophagy induction2018
- Author(s)
  Yuji Kakiuchi+, Takashi Yurube*, Yoshiki Takeoka+, Masaaki Ito+, Yutaro Kanda+, Kenichiro Kakutani*, Toru Takada, Ryosuke Kuroda*, Kotaro Nishida*
- Organizer
  International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス・セネッセンスを誘導するが、細胞外基質代謝への影響は少ない2018
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] The fate of notochordal cell in intervertebral disc degeneration induced by dynamic compressive load through integrin alpha5/beta1 mechanotransduction2018
- Author(s)
  Yutaro Kanda+, Kenichiro Kakutani*, Yusuke Morita, Takashi Yurube*, Masaaki Ito+, Yuji Kakiuchi+, Yoshiki Takeoka+, Takuto Kurakawa, Yoshiki Terashima, Toru Takada, Ryosuke Kuroda*, Kotaro Nishida*
- Organizer
  International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] テムシロリムスのヒト椎間板髄核細胞保護効果はオートファジー及びAktの活性化に由来する2018
- Author(s)
  垣内　裕司+、由留部　崇*、角谷　賢一朗*、高田　徹、伊藤　雅明+、武岡　由樹+、神田　裕太郎+、黒田　良祐*、西田　康太郎*
- Organizer
  日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Autophagy plays protective roles against human disc cellular apoptosis, senescence, and extracellular matrix degradation2018
- Author(s)
  M. Ito, T. Yurube, K. Kakutani, T. Takada, Y. Kakiuchi, Y. Takeoka, Y. Kanda, R. Kuroda, K. Nishida
- Organizer
  45th The International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells2017
- Author(s)
  Masaaki Ito, Takashi Yurube, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Yoshiki Terashima, Yuji Kakiuchi, Yoshiki Takeoka, Ryosuke Kuroda, Kotaro Nishida
- Organizer
  The 44th International Society for the Study of the Lumbar Spine（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板髄核におけるオートファジーの重要性とその脊索表現型保持への関与の可能性2017
- Author(s)
  由留部　崇、伊藤雅明、垣内裕司、寺島良樹、武岡由樹、角谷賢一郎、前野耕一郎、高田徹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 脊椎椎間板変性へのオートファジーの関与とその脊索由来細胞における恒常性維持機構の可能性2017
- Author(s)
  由留部　崇、伊藤雅明、垣内裕司、寺島良樹、武岡由樹、角谷賢一郎、前野耕一郎、高田　徹、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田　徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Involvement of autophagy in intervertebral disc degeneration and its possible contribution to the maintenance of notochordal cell homeostasis2017
- Author(s)
  Takashi Yurube, Hiroaki Hirata, Masaaki Ito, Yoshiki Terashima, Yuji Kakiuchi, Yoshiki Takeoka, Shingo Miyazaki, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Ryosuke Kuroda, Kotaro Nishida
- Organizer
  The 44th International Society for the Study of the Lumbar Spine（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス、セネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction2016
- Author(s)
  to M., Yurube T., Kakutani K., Maeno K., Takada T., Miyazaki S., Terashima Y., Kakiuchi Y., Kurosaka M., Nishida K.
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板では他の筋骨格系組織よりもオートファジーの関与が大きく、その活性は変性とともに減少する：オートファジー制御による椎間板変性予防の可能性2016
- Author(s)
  由留部崇、平田裕亮、伊藤雅明、垣内裕司、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺島良樹、黒坂昌弘、西田康太郎
- Organizer
  第４５回　日本脊椎脊髄病学会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し、ヒト椎間板細胞における細胞死、老化と細胞外気質分解を抑制する2016
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺島良樹、垣内裕司、黒坂昌弘、西田康太郎
- Organizer
  第４５回　日本脊椎脊髄病学会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Intervertebral disc nucleus pulposus has intensive involvement of autophagy compared to other musculoskeletal tissues and its degeneration is linked with decreased autophagy2016
- Author(s)
  Yurube T., Hirata H., Ito M., Kakiuchi Y., Kakutani K., Maeno K., Takada T., Miyazaki S., Terashima Y., Kurosaka M., Nishida K.
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目指した棘突起間スペーサーの開発2016
- Author(s)
  西田康太郎、前野耕一郎、角谷賢一朗、由留部　崇、高田　徹、伊藤雅明、寺嶋良樹、垣内裕司、武岡由樹
- Organizer
  第２４回　日本腰痛学会
- Place of Presentation
  山梨
- Year and Date
  2016-09-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] M1 MACROPHAGE EXISTS IN THE DEGENERATIVE DISC2014
- Author(s)
  Toru Takada
- Organizer
  The International Society for he Study of the Lumbar Spine
- Place of Presentation
  ソウル　韓国
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] 脊椎変性疾患の変性椎間板にはM1マクロファージが存在する2014
- Author(s)
  高田徹
- Organizer
  第43回脊椎脊髄病学会
- Place of Presentation
  京都　日本
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] 非ヘルニア変性椎間板には古典的活性化(M1)マクロファージが存在する2013
- Author(s)
  高田徹、前野耕一郎、角谷賢一朗、張　鍾穎、由留部　崇、山本潤哉、平田裕亮、蔵川拓外、宮崎真吾、土井田　稔、黒坂　昌弘、西田　康太郎
- Organizer
  第42回脊椎脊髄病学会
- Place of Presentation
  沖縄　コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] M1 MACROPHAGE EXISTS IN THE NON-HERNIATED DEGENERATIVE DISC.2013
- Author(s)
  T. Takada, K. Maeno, K. Kakutani, T. Yurube, J. Yamamoto, H. Hirata, T. Kurakawa, S. Miyazaki, M. Kurosaka, K. Nishida
- Organizer
  2013 The International Society for Study of the Lumbar Spine
- Place of Presentation
  Scottsdale　USA
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] M1 MACROPHAGE EXISTS IN THE DEGENERATIVE DISC
- Author(s)
  T. Takada, K. Maeno, K. Kakutani, T. Yurube, H. Hirata, T. Kurakawa, S. Miyazaki, Y. Terashima, M Doita, M. Kurosaka, K. Nishida
- Organizer
  International Society for the study of Lumbar Spine
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-06-03 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] 脊椎変性疾患の変性椎間板にはM1マクロファージが存在する
- Author(s)
  高田　徹、前野　耕一郎、角谷　賢一朗、由留部　崇、平田　裕亮、蔵川　拓外、宮崎　真吾　寺嶋　良樹
- Organizer
  第４３回脊椎脊髄病学会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-04-17 – 2014-04-19
- Data Source
  KAKENHI-PROJECT-24592195

1. NISHIDA Kotaro (00379372)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
2. KAKUTANI Kenichiro (10533739)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
3. MAENO Koichiro (70403269)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. 由留部崇 (10514648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results

TAKADA Toru 高田 徹

Research Projects

Research Products

Co-Researchers

Elucidation of pathogenesis of low back pain related to degeneration of intervertebral disc and development of minimally invasive treatment system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pathomechanism of nociceptive pain and neuropathic pain in herniated disc diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] オートファジーと椎間板変性2018

Author(s)

Journal Title

Data Source

[Journal Article] Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Autophagy plays protective roles against human disc cellular apoptosis, senescence, and extracellular matrix degradation2018

Author(s)

Organizer

Data Source

[Presentation] 椎間板動的圧迫負荷が脊索由来髄核細胞に及ぼした影響2018

Author(s)

Organizer

Data Source

[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor to protect human disc cells depending on Akt and autophagy induction2018

Author(s)

Organizer

Data Source

[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス・セネッセンスを誘導するが、細胞外基質代謝への影響は少ない2018

Author(s)

Organizer

Data Source

[Presentation] The fate of notochordal cell in intervertebral disc degeneration induced by dynamic compressive load through integrin alpha5/beta1 mechanotransduction2018

Author(s)

Organizer

Data Source

[Presentation] テムシロリムスのヒト椎間板髄核細胞保護効果はオートファジー及びAktの活性化に由来する2018

Author(s)

Organizer

Data Source

[Presentation] Autophagy plays protective roles against human disc cellular apoptosis, senescence, and extracellular matrix degradation2018

Author(s)

Organizer

Data Source

[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells2017

Author(s)

Organizer

Data Source

[Presentation] 椎間板髄核におけるオートファジーの重要性とその脊索表現型保持への関与の可能性2017

Author(s)

Organizer

Data Source

[Presentation] 脊椎椎間板変性へのオートファジーの関与とその脊索由来細胞における恒常性維持機構の可能性2017

Author(s)

Organizer

Data Source

[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる2017

Author(s)

Organizer

Data Source

[Presentation] Involvement of autophagy in intervertebral disc degeneration and its possible contribution to the maintenance of notochordal cell homeostasis2017

TAKADA Toru 高田徹